asta-z-7557 and Lymphoma

asta-z-7557 has been researched along with Lymphoma* in 3 studies

Reviews

1 review(s) available for asta-z-7557 and Lymphoma

ArticleYear
Pharmacological purging of bone marrow with reference to autografting.
    Clinics in haematology, 1986, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Etoposide; Graft vs Host Disease; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lysophosphatidylcholines; Methylprednisolone; Neoplasms, Experimental; Phospholipid Ethers; Pyrimidinones; Transplantation, Autologous; Transplantation, Isogeneic

1986

Trials

1 trial(s) available for asta-z-7557 and Lymphoma

ArticleYear
Pharmacological purging of bone marrow with reference to autografting.
    Clinics in haematology, 1986, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Etoposide; Graft vs Host Disease; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lysophosphatidylcholines; Methylprednisolone; Neoplasms, Experimental; Phospholipid Ethers; Pyrimidinones; Transplantation, Autologous; Transplantation, Isogeneic

1986

Other Studies

2 other study(ies) available for asta-z-7557 and Lymphoma

ArticleYear
Increased efficiency in selective elimination of leukemia cells by a combination of a stable derivative of cyclophosphamide and a human B-cell-specific immunotoxin containing pokeweed antiviral protein.
    Cancer research, 1985, Volume: 45, Issue:1

    Leukemia cells were mixed with normal human bone marrow cells to simulate bone marrow from leukemia patients; the mixture was then treated with a combination of stabilized derivative of cyclophosphamide [Mafosfamide (ASTA Z 7557)] and pokeweed antiviral protein-containing immunotoxin. The ability of this protocol for selective elimination of B-ALL cells was evaluated by clonogenic assay. The monoclonal antibody (B43) portion of the immunotoxin was directed against human B-cells and was linked to pokeweed antiviral protein by a disulfide bond. The combination of ASTA Z 7557 and immunotoxin was superior to either ASTA Z 7557 or the immunotoxin alone and produced nearly 7 logs of elimination of leukemia cells from the cell mixtures. About 5 logs of contaminating tumor cells were eliminated from a 200-fold excess of normal marrow under conditions where fewer than 50% of pluripotent stem cells were lost. Moreover, this manipulation did not inhibit subsequent production of pluripotent stem cells in long-term bone marrow cultures, indicating that the more primitive progenitors were not harmed.

    Topics: Antibodies, Monoclonal; Antiviral Agents; B-Lymphocytes; Bone Marrow Cells; Cell Line; Cell Survival; Cells, Cultured; Chloroquine; Cyclophosphamide; Drug Synergism; Flow Cytometry; Humans; Leukemia, Lymphoid; Lymphoma; N-Glycosyl Hydrolases; Plant Proteins; Ribosome Inactivating Proteins, Type 1; Tumor Stem Cell Assay

1985
Antineoplastic activity of ASTA Z 7557 (INN mafosfamide) in transplanted and autochthonous experimental rodent tumors.
    Investigational new drugs, 1984, Volume: 2, Issue:2

    The antineoplastic activities of ASTA Z 7557 and cyclophosphamide (CPA) were compared in advanced transplanted AKR lymphoma by determining the optimal dose using single dose and twofold applications. Autochthonous DMBA-induced leukemias and MNU-induced mammary carcinomas were treated with fractionated doses over 3 and 5 weeks, respectively. In the respective optimal dosages ASTA Z 7557 exhibited an antitumor effect comparable to that of CPA in all three models. The results obtained by treatment of the autochthonous models indicate that Z 7557 seems to have advantages over CPA in the treatment of malignancies with impaired bone marrow function as for instance acute leukemias and in fractionated dose schedules.

    Topics: Animals; Cyclophosphamide; Female; Leukemia, Experimental; Lymphoma; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred AKR; Neoplasm Transplantation; Rats; Rats, Inbred Strains

1984