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aspirin and Ventricular Fibrillation

aspirin has been researched along with Ventricular Fibrillation in 29 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.

Research Excerpts

ExcerptRelevanceReference
" The effect of the nitro-derivative of aspirin, NCX4016, was assessed on ischaemic ventricular arrhythmias and myocardial infarct size in anaesthetized pigs in comparison to native aspirin."7.71NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs. ( Del Soldato, P; Miller, AM; Wainwright, CL; Work, LM, 2002)
"We describe the mortality during the subsequent 5 years after development of acute myocardial infarction prior to and after the introduction of a more widespread use of thrombolytic agents and aspirin in the community of Göteborg."7.70Long-term survival after development of acute myocardial infarction has improved after a more widespread use of thrombolysis and aspirin. ( Abrahamsson, P; Dellborg, M; Herlitz, J; Karlson, BW; Karlsson, T; Lindqvist, J, 1999)
"The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1."7.69Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994)
"The effects of arginine aspirin (AAs) on the effective refractory period (ERP) and ventricular fibrillation threshold (VFT) of ischemic ventricular muscle were observed in 24 anesthetized open-chest rabbits."7.67[Effects of arginine aspirin on changes in effective refractory period and ventricular fibrillation threshold of ischemic myocardium in rabbit]. ( Wu, BW; Zang, YM; Zhao, RR; Zhao, ZQ; Zhou, YY; Zhu, MZ, 1989)
"ASA, captopril or losartan were given at a concentration of 40 mg/kg/day in drinking water."5.32Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. ( Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2003)
"In the CLARITY-TIMI 28 (Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis In Myocardial Infarction 28) study, 3,491 patients underwent angiography a median of 3."5.13Association of impaired thrombolysis in myocardial infarction myocardial perfusion grade with ventricular tachycardia and ventricular fibrillation following fibrinolytic therapy for ST-segment elevation myocardial infarction. ( Buros, JL; Cannon, CP; Gibson, CM; Josephson, ME; Lord, E; Murphy, SA; Pinto, DS; Pride, YB; Sabatine, MS; Shui, A; Zimetbaum, PJ, 2008)
" We present a case of postoperative simultaneous left anterior descending and right coronary stent thrombosis that followed cessation of long-term aspirin therapy in a patient with stable coronary artery disease."3.78Simultaneous left anterior descending and right coronary stent thrombosis after aspirin withdrawal. ( Abdelmalak, HD; Camporesi, EM; Karlnoski, R; Mangar, D; Omar, HR, 2012)
" The effect of the nitro-derivative of aspirin, NCX4016, was assessed on ischaemic ventricular arrhythmias and myocardial infarct size in anaesthetized pigs in comparison to native aspirin."3.71NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs. ( Del Soldato, P; Miller, AM; Wainwright, CL; Work, LM, 2002)
"We describe the mortality during the subsequent 5 years after development of acute myocardial infarction prior to and after the introduction of a more widespread use of thrombolytic agents and aspirin in the community of Göteborg."3.70Long-term survival after development of acute myocardial infarction has improved after a more widespread use of thrombolysis and aspirin. ( Abrahamsson, P; Dellborg, M; Herlitz, J; Karlson, BW; Karlsson, T; Lindqvist, J, 1999)
"Mortality after acute myocardial ischemia has been reduced by aspirin (ASA) but mechanisms other than the antiplatelet effect have not been established."3.70Nonplatelet effects of aspirin during acute coronary occlusion: electrophysiologic and cation alterations in ischemic myocardium. ( Arena, J; Moschos, CB; Regan, TJ; Shehadeh, AA, 2000)
"The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1."3.69Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994)
"To evaluate the impact of introducing thrombolytic and aspirin therapy into the management policy of a coronary care unit, with particular reference to its effects on the hospital course of nonselected patients with acute myocardial infarction."3.68Clinical impact of introducing thrombolytic and aspirin therapy into the management policy of a coronary care unit. ( Ranjadayalan, K; Timmis, AD; Umachandran, V, 1992)
"The effects of arginine aspirin (AAs) on the effective refractory period (ERP) and ventricular fibrillation threshold (VFT) of ischemic ventricular muscle were observed in 24 anesthetized open-chest rabbits."3.67[Effects of arginine aspirin on changes in effective refractory period and ventricular fibrillation threshold of ischemic myocardium in rabbit]. ( Wu, BW; Zang, YM; Zhao, RR; Zhao, ZQ; Zhou, YY; Zhu, MZ, 1989)
" There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis."3.65Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973)
"We analyzed the incidence and recurrence rate of early and late primary VF in 9,720 patients with a first acute MI, treated with thrombolytics, enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-2 trial."2.69Incidence and prognosis of early primary ventricular fibrillation in acute myocardial infarction--results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2) database. ( Cavalli, A; Negri, E; Santoro, L; Volpi, A, 1998)
"ASA, captopril or losartan were given at a concentration of 40 mg/kg/day in drinking water."1.32Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. ( Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2003)
" After controlling for age, prehospital dosage of epinephrine, and the duration of cardiac arrest we found a non significant trend towards good neurological recovery when thrombolytic therapy was given (OR 1."1.31Thrombolytic therapy after cardiac arrest and its effect on neurological outcome. ( Gabriel, D; Holzer, M; Kuerkciyan, I; Laggner, AN; Muellner, M; Schreiber, W; Sterz, F, 2002)
"An increase in the risk of ventricular arrhythmias under conditions of both ischaemia and reperfusion was obvious in the rats that consumed large quantities of saturated fatty acids (coconut oil) and in the group with a very low intake of fat."1.29Differential effects of various oil diets on the risk of cardiac arrhythmias in rats. ( Isensee, H; Jacob, R, 1994)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19908 (27.59)18.7374
1990's8 (27.59)18.2507
2000's9 (31.03)29.6817
2010's2 (6.90)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Eroglu, TE1
Blom, MT1
Souverein, PC1
Yasmina, A1
de Boer, A1
Tan, HL1
Mercado-Lubo, R1
Yarzebski, J1
Lessard, D1
Gore, J1
Goldberg, RJ1
Jang, SW1
Kim, DB1
Kwon, BJ1
Shin, D1
Her, SH1
Park, CS1
Park, HJ1
Park, MW1
Cho, EJ1
Rho, TH1
Kim, JH1
Omar, HR1
Mangar, D1
Karlnoski, R1
Abdelmalak, HD1
Camporesi, EM1
Seniuk, W1
Mularek-Kubzdela, T1
Grygier, M1
Grajek, S1
Cieśliński, A1
Al-Khatib, SM1
Stebbins, AL1
Califf, RM1
Lee, KL1
Granger, CB1
White, HD1
Armstrong, PW1
Topol, EJ1
Ohman, EM1
Zhu, BQ1
Sievers, RE1
Browne, AE1
Lee, RJ1
Chatterjee, K1
Grossman, W1
Karliner, JS1
Parmley, WW1
Gibson, CM1
Pride, YB1
Buros, JL1
Lord, E1
Shui, A1
Murphy, SA1
Pinto, DS1
Zimetbaum, PJ1
Sabatine, MS1
Cannon, CP1
Josephson, ME1
Boissel, JP1
Leizorovicz, A1
Faucomprez, C1
Packham, MA1
Mustard, JF1
Bhatti, AS1
Khan, HH1
Isensee, H1
Jacob, R1
Barrabés, JA1
Garcia-Dorado, D1
Oliveras, J1
González, MA1
Ruiz-Meana, M1
Solares, J1
Burillo, AG1
Lidón, RM1
Antolín, M1
Castell, J1
Soler-Soler, J1
Dhein, S1
Gottwald, M1
Gottwald, E1
Hohlfeld, T1
Salameh, A1
Klaus, W1
Volpi, A1
Cavalli, A1
Santoro, L1
Negri, E1
Herlitz, J1
Abrahamsson, P1
Dellborg, M1
Karlson, BW1
Karlsson, T1
Lindqvist, J1
Jeong, MH1
Park, JC2
Rhew, JY1
Kang, KT1
Lee, SH1
Cho, JH1
Kim, NH1
Kim, KH1
Ahn, YK1
Bae, Y1
Cho, JG1
Kim, SH1
Kang, JC1
Shehadeh, AA1
Arena, J1
Moschos, CB2
Regan, TJ2
Gheeraert, PJ1
Henriques, JP1
De Buyzere, ML1
De Pauw, M1
Taeymans, Y1
Zijlstra, F1
Schreiber, W1
Gabriel, D1
Sterz, F1
Muellner, M1
Kuerkciyan, I1
Holzer, M1
Laggner, AN1
Wainwright, CL1
Miller, AM1
Work, LM1
Del Soldato, P1
Wilkerson, RD1
Glenn, TM1
Haider, B1
De La Cruz, C1
Lyons, MM1
Gustafson, A1
Gustafsson, B1
Ranjadayalan, K1
Umachandran, V1
Timmis, AD1
Oates, JA1
Zhao, ZQ1
Zang, YM1
Zhu, MZ1
Zhou, YY1
Wu, BW1
Zhao, RR1
Huang, TF1
Yang, BB1
Harrison, JF1
Parker, RW1
De Silva, KL1

Reviews

3 reviews available for aspirin and Ventricular Fibrillation

ArticleYear
Cardiac death prevention in post-myocardial infarction patients: a review.
    Acta cardiologica. Supplementum, 1980, Issue:25

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Animals; Anti-Arrhythmia Agents; Anticoagu

1980
Pharmacology of platelet-affecting drugs.
    Circulation, 1980, Volume: 62, Issue:6 Pt 2

    Topics: Animals; Arachidonic Acids; Arteriosclerosis; Aspirin; Blood Platelets; Cyclic AMP; Dose-Response Re

1980
The Jeremiah Metzger lecture. Participation of eicosanoids in the syndromes of myocardial ischemia.
    Transactions of the American Clinical and Climatological Association, 1990, Volume: 101

    Topics: Angina, Unstable; Arteriosclerosis; Aspirin; Coronary Disease; Eicosanoids; Humans; Myocardial Infar

1990

Trials

4 trials available for aspirin and Ventricular Fibrillation

ArticleYear
Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: results from the GUSTO-III trial.
    American heart journal, 2003, Volume: 145, Issue:3

    Topics: Acute Disease; Aged; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Heparin; Hospi

2003
Association of impaired thrombolysis in myocardial infarction myocardial perfusion grade with ventricular tachycardia and ventricular fibrillation following fibrinolytic therapy for ST-segment elevation myocardial infarction.
    Journal of the American College of Cardiology, 2008, Feb-05, Volume: 51, Issue:5

    Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Circulati

2008
Cardiac death prevention in post-myocardial infarction patients: a review.
    Acta cardiologica. Supplementum, 1980, Issue:25

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Animals; Anti-Arrhythmia Agents; Anticoagu

1980
Incidence and prognosis of early primary ventricular fibrillation in acute myocardial infarction--results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2) database.
    The American journal of cardiology, 1998, Aug-01, Volume: 82, Issue:3

    Topics: Anti-Arrhythmia Agents; Anticoagulants; Aspirin; Atenolol; Drug Administration Routes; Electrocardio

1998

Other Studies

23 other studies available for aspirin and Ventricular Fibrillation

ArticleYear
Acetylsalicylic acid use is associated with reduced risk of out-of-hospital cardiac arrest in the general population: Real-world data from a population-based study.
    PloS one, 2022, Volume: 17, Issue:6

    Topics: Aspirin; Calcium; Cardiopulmonary Resuscitation; Case-Control Studies; Female; Humans; Male; Myocard

2022
Changing Trends in the Landscape of Patients Hospitalized With Acute Myocardial Infarction (2001 to 2011) (from the Worcester Heart Attack Study).
    The American journal of cardiology, 2020, 03-01, Volume: 125, Issue:5

    Topics: Adrenergic beta-Antagonists; Age Distribution; Aged; Aged, 80 and over; Angiotensin Receptor Antagon

2020
Death caused by simultaneous subacute stent thrombosis of sirolimus-eluting stents in left anterior descending artery and left circumflex artery.
    International journal of cardiology, 2010, Apr-01, Volume: 140, Issue:1

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Occ

2010
Simultaneous left anterior descending and right coronary stent thrombosis after aspirin withdrawal.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:9

    Topics: Aged; Aspirin; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stent

2012
Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study.
    Journal of internal medicine, 2002, Volume: 252, Issue:4

    Topics: Amiodarone; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Car

2002
Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2003, Volume: 4, Issue:1

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhib

2003
Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study.
    JPMA. The Journal of the Pakistan Medical Association, 1994, Volume: 44, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Cardiac Complexes, Premature; Cause of Death

1994
Differential effects of various oil diets on the risk of cardiac arrhythmias in rats.
    Journal of cardiovascular risk, 1994, Volume: 1, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Aspirin; Cardiac Complexes, Premature; Coconut Oil; Cocos; Corn Oil;

1994
Intimal injury in a transiently occluded coronary artery increases myocardial necrosis. Effect of aspirin.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 432, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Cell Count; Coronary

1996
Acetylsalicylic acid enhances arrhythmogeneity in a model of local ischemia of isolated rabbit hearts.
    European journal of pharmacology, 1997, Nov-27, Volume: 339, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Coronary Circulatio

1997
Long-term survival after development of acute myocardial infarction has improved after a more widespread use of thrombolysis and aspirin.
    Cardiology, 1999, Volume: 91, Issue:4

    Topics: Aged; Aspirin; Cardiotonic Agents; Confidence Intervals; Female; Fibrinolytic Agents; Humans; Likeli

1999
Successful management of intractable coronary spasm with a coronary stent.
    Japanese circulation journal, 2000, Volume: 64, Issue:11

    Topics: Adult; Amlodipine; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; C

2000
Nonplatelet effects of aspirin during acute coronary occlusion: electrophysiologic and cation alterations in ischemic myocardium.
    Journal of cardiovascular pharmacology and therapeutics, 2000, Volume: 5, Issue:2

    Topics: Action Potentials; Animals; Aspirin; Coronary Disease; Dogs; Epinephrine; Male; Myocardial Ischemia;

2000
Preinfarction angina protects against out-of-hospital ventricular fibrillation in patients with acute occlusion of the left coronary artery.
    Journal of the American College of Cardiology, 2001, Nov-01, Volume: 38, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Analysis of Variance; Angina Pectoris; Aspirin; Case-Control Stud

2001
Thrombolytic therapy after cardiac arrest and its effect on neurological outcome.
    Resuscitation, 2002, Volume: 52, Issue:1

    Topics: Aged; Aspirin; Cardiopulmonary Resuscitation; Case-Control Studies; Cerebrovascular Circulation; Con

2002
NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs.
    British journal of pharmacology, 2002, Volume: 135, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Coronary Disease; E

2002
Influence of nonsteroidal anti-inflammatory drugs on ouabain toxicity.
    American heart journal, 1977, Volume: 94, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Aspirin; Cyclooxygenase Inhibitors; Dogs; F

1977
Antiarrhythmic effects of aspirin during nonthrombotic coronary occlusion.
    Circulation, 1978, Volume: 57, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Aspirin; Blood Pressure; Coronary Disease; Dogs; Fatty Acids, Nones

1978
Acute poisoning with dextropropoxyphene. Clinical symptoms and plasma concentrations.
    Acta medica Scandinavica, 1976, Volume: 200, Issue:4

    Topics: Acidosis; Acute Disease; Adolescent; Adult; Arrhythmia, Sinus; Aspirin; Barbiturates; Dextropropoxyp

1976
Clinical impact of introducing thrombolytic and aspirin therapy into the management policy of a coronary care unit.
    The American journal of medicine, 1992, Volume: 92, Issue:3

    Topics: Age Factors; Aged; Aspirin; Coronary Care Units; Diuretics; Drug Therapy, Combination; Female; Hospi

1992
[Effects of arginine aspirin on changes in effective refractory period and ventricular fibrillation threshold of ischemic myocardium in rabbit].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:10

    Topics: Animals; Aspirin; Coronary Disease; Female; Male; Neural Conduction; Platelet Aggregation; Platelet

1989
Effects of vagotomy and drugs on the ventricular fibrillation threshold of normal and ischemic hearts in the anesthetized rat.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 278, Issue:1

    Topics: Adenosine; Anesthesia; Animals; Aspirin; Blood Pressure; Bretylium Compounds; Coronary Disease; Hear

1985
Lysozymuria and acute disorders of renal function.
    Journal of clinical pathology, 1973, Volume: 26, Issue:4

    Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo

1973