aspirin and Uremia studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

Research Excerpts

Excerpt	Relevance	Reference
"We reported that aspirin (ASA) abnormally prolongs bleeding time (BT) in uremia."	7.67	Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition. ( Bonati, M; Gaspari, F; Livio, M; Orisio, S; Remuzzi, G; Viganò, G, 1987)
"Dialysis did not affect the antiplatelet effects of aspirin and clopidogrel in uremic patients with coronary heart disease."	3.85	Effect of Dialysis on Antiplatelet Drug Efficacy in Uremic Patients with Coronary Heart Disease. ( Fu, DL; Gao, YX; Li, XL; Liu, XF; Lu, HK; Peng, WH; Wang, Q; Wang, Y; Yang, P; Zhang, H; Zhao, TT; Zheng, JG, 2017)
"We reported that aspirin (ASA) abnormally prolongs bleeding time (BT) in uremia."	3.67	Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition. ( Bonati, M; Gaspari, F; Livio, M; Orisio, S; Remuzzi, G; Viganò, G, 1987)
" There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis."	3.65	Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973)

Research

Studies (46)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Count of All Participants With Bleeding Events

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (82.61)	18.7374
1990's	3 (6.52)	18.2507
2000's	2 (4.35)	29.6817
2010's	3 (6.52)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Fu, DL	1
Zhao, TT	1
Peng, WH	1
Yang, P	1
Liu, XF	1
Zhang, H	1
Li, XL	1
Wang, Y	1
Zheng, JG	1
Gao, YX	1
Lu, HK	1
Wang, Q	1
Liu, H	1
Lu, H	1
Basra, SS	1
Tsai, P	1
Lakkis, NM	1
Panichi, V	1
Taccola, D	1
Migliori, M	1
Consani, C	1
Giovannini, L	1
Tetta, C	1
Rodrigue, ME	1
Lacasse-M, S	1
Larivière, R	1
Lebel, M	1
Remuzzi, G	6
Benigni, A	1
Dodesini, P	1
Schieppati, A	2
Livio, M	2
De Gaetano, G	2
Day, SS	1
Smith, WL	1
Pinca, E	1
Patrignani, P	1
Patrono, C	1
Lind, SE	1
Weksler, BB	1
Montgomery, RR	1
Hathaway, WE	1
Malpass, TW	1
Harker, LA	3
Marchesi, D	1
Poletti, E	1
Mecca, G	1
Donati, MB	1
Rossi, EC	1
Viganò, G	2
Caravaca, F	1
López-Minguez, JR	1
Arrobas, M	1
Cubero, J	1
Pizarro, JL	1
Cid, MC	1
Sanchez-Casado, E	1
Miranda, MP	1
Tschugguel, W	1
Blaicher, A	1
Kramer, L	1
Felfernig, M	1
Jüngling, G	1
Kurz, M	1
Gnant, M	1
Zimpfer, M	1
Porter, RJ	1
Layzer, RB	1
Köhler, H	1
Kramer, P	1
Farrell, PC	1
Ward, RA	1
Hone, PW	1
Gaspari, F	2
Orisio, S	1
Bonati, M	1
Jergens, AE	1
Turrentine, MA	1
Kraus, KH	1
Johnson, GS	1
Locatelli, M	1
David, DS	1
Steere, AC	1
Pi-Sunyer, XF	1
Sakai, S	1
Clark, SB	1
Sutor, AH	1
Schindera, F	1
Jacobi, H	1
Künzer, W	1
Murray, RM	1
Timbury, GC	1
Linton, AL	2
MacKenzie, RD	1
Thompson, RJ	1
Gleason, EM	1
Sahud, MA	2
Schöndoft, TH	1
Hey, D	1
Slichter, SJ	2
Rabiner, SF	1
Weiss, HJ	1
Amorosi, EL	1
Andrassy, K	2
Malluche, H	1
Bornefeld, H	1
Comberg, M	1
Ritz, E	2
Jesdinsky, H	1
Möhring, K	1
George, CR	1
Quadracci, LJ	1
Striker, GE	1
Hunt, TK	1
Harrison, JF	1
Parker, RW	1
De Silva, KL	1
Utting, JA	1
Shreeve, DR	1
Dacie, JV	1
Marcus, AJ	1
Hahn, G	1
Schöffner, W	1
Cohen, RJ	1
Lunde, KM	1
Kincaid-Smith, P	1
Horowitz, HI	1
McMillan, JM	1
Lawson, DH	1
Paton, AM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Platelet Aggregation and Adenosine Levels in Patients With Coronary Artery Disease and Chronic Kidney Dysfunction Taking Dual Antiplatelet Therapy With Aspirin and Clopidogrel or Ticagrelor[NCT03039205]	Phase 2	90 participants (Actual)	Interventional	2017-11-07	Completed
A Double-blind, Randomized, Placebo Controlled Pilot Trial to Evaluate the Safety and Efficacy of Vorapaxar in Maturation of Arteriovenous Fistulae for Hemodialysis Access[NCT02475837]	Phase 2	17 participants (Actual)	Interventional	2015-08-26	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Bleeding events according to GUSTO (criteria for bleeding: Severe, Moderate or Mild) and BARC (bleeding criteria Type 0-5, with 0 being no bleeding and 5 referring to probable or definite fatal bleeding) Criteria (NCT02475837)
Timeframe: up to 238 days

Count of Participants With AV Fistula Use

Intervention	Participants (Count of Participants)
Vorapaxar Intervention	0
Placebo Intervention	1

Participants able to use their AV fistula for dialysis within 180 days of surgery were considered to have met the outcome. (NCT02475837)
Timeframe: up to 238 days

Count Participants With AV Fistula Patency

Intervention	Participants (Count of Participants)
Vorapaxar Intervention	2
Placebo Intervention	4

Criteria for outcome: AV fistula patency at 150-180 days, with at least 50% increase in vein diameter by ultrasound compared with preoperative vein diameter measurement. (NCT02475837)
Timeframe: 150-238 days

Time to AV Fistula Functional Maturation

Intervention	Participants (Count of Participants)
Vorapaxar Intervention	1
Placebo Intervention	5

Time to AV fistula functional maturation (defined as successful cannulation of the AV fistula for six hemodialysis sessions within three weeks). (NCT02475837)
Timeframe: up to 238 days

Article	Year
Safety and efficacy of antiplatelet and antithrombotic therapy in acute coronary syndrome patients with chronic kidney disease. Journal of the American College of Cardiology, 2011, Nov-22, Volume: 58, Issue:22 Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chronic Disease; Clinical Trials as Topic; Clopidogrel;	2011
The role of chronic inflammation in cardiovascular mortality of uremic patients. The International journal of artificial organs, 2003, Volume: 26, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C-Reactive Protein; Cardiovascular Diseases; Human	2003
Prolonged bleeding time. The American journal of medicine, 1984, Volume: 77, Issue:2 Topics: Aspirin; Bleeding Time; Blood Coagulation Disorders; Cryoglobulins; Evaluation Studies as Topic; Fac	1984
Prostacyclin. Progress in hemostasis and thrombosis, 1982, Volume: 6 Topics: Adenylyl Cyclases; Adult; Animals; Arteriosclerosis; Aspirin; Blood Platelet Disorders; Blood Platel	1982
Acquired disorders of platelet function. Seminars in hematology, 1980, Volume: 17, Issue:4 Topics: Alcoholism; Amyloidosis; Anti-Bacterial Agents; Aspirin; Blood Platelet Disorders; Blood Platelets;	1980
Bleeding disorders in uremia: pathophysiology and treatment. Advances in nephrology from the Necker Hospital, 1989, Volume: 18 Topics: Aspirin; Blood Platelet Disorders; Deamino Arginine Vasopressin; Estrogens; Hemorrhage; Humans; Urem	1989
Bleeding in renal failure. Lancet (London, England), 1988, May-28, Volume: 1, Issue:8596 Topics: Anemia; Aspirin; Bleeding Time; Blood Platelets; Blood Transfusion; Cryoprotective Agents; Deamino A	1988
Platelet disorders: a review of disturbances in adhesion, aggregation, and release reaction. California medicine, 1972, Volume: 116, Issue:1 Topics: Adenosine Diphosphate; Afibrinogenemia; Anemia; Aspirin; Blood Platelet Disorders; Connective Tissue	1972
Bleeding in uremia. The Medical clinics of North America, 1972, Volume: 56, Issue:1 Topics: Adenine Nucleotides; Aspirin; Blood Coagulation Disorders; Blood Platelet Disorders; Capillary Fragi	1972
Bleeding disorders due to abnormal platelet function. The Medical clinics of North America, 1973, Volume: 57, Issue:2 Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Fa	1973
Acute manifestations of platelet dysfunction. The Medical clinics of North America, 1973, Volume: 57, Issue:6 Topics: Acute Disease; Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; B	1973
Platelet function. The New England journal of medicine, 1969, Jun-05, Volume: 280, Issue:23 Topics: Adenine Nucleotides; Afibrinogenemia; Age Factors; Anemia, Hypochromic; Animals; Aspirin; Blood Cell	1969

Article	Year
Effect of Aspirin on Reducing Thrombosis of Arteriovenous Fistulae in Uremic Patients Undergoing Hemodialysis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2019, Volume: 29, Issue:6 Topics: Arteriovenous Fistula; Arteriovenous Shunt, Surgical; Aspirin; Catheters, Indwelling; Female; Fibrin	2019
Haemodynamic changes induced by the correction of anaemia by erythropoietin: role of antiplatelet therapy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1995, Volume: 10, Issue:9 Topics: Adult; Aged; Anemia; Aspirin; Dipyridamole; Erythropoietin; Female; Hemodynamics; Humans; Male; Midd	1995
Platelet disorders in uraemia before and after haemodialysis under the influence of low dose aspirin. Thrombosis research, 1995, Nov-01, Volume: 80, Issue:3 Topics: Adult; Aged; Aspirin; Bleeding Time; Blood Platelets; Female; Hematocrit; Hemorrhage; Humans; Male;	1995
Prevention of p.o. clotting of av. cimino fistulae with acetylsalicyl acid. Results of a prospective double blind study. Klinische Wochenschrift, 1974, Apr-01, Volume: 52, Issue:7 Topics: Arteriovenous Shunt, Surgical; Aspirin; Blood Coagulation; Clinical Trials as Topic; Female; Humans;	1974

Article	Year
Effect of Dialysis on Antiplatelet Drug Efficacy in Uremic Patients with Coronary Heart Disease. Chinese medical journal, 2017, Aug-20, Volume: 130, Issue:16 Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Platelet Aggregatio	2017
Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats. Canadian journal of physiology and pharmacology, 2005, Volume: 83, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Aspirin; Blood Pressure; Cyclooxygenase Inhi	2005
Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect. The Journal of clinical investigation, 1983, Volume: 71, Issue:3 Topics: Adult; Aged; Arachidonic Acids; Aspirin; Blood Platelets; Cyclic AMP; Female; Humans; Male; Middle A	1983
Acute bleeding emergencies. Pediatric clinics of North America, 1980, Volume: 27, Issue:2 Topics: Acute Disease; Aspirin; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Vessels; Child;	1980
Aspirin and thrombosis in patients undergoing hemodialysis. The New England journal of medicine, 1980, Jun-19, Volume: 302, Issue:25 Topics: Aspirin; Humans; Renal Dialysis; Thrombosis; Uremia	1980
Low-dose aspirin and bleeding in uremia. American journal of hematology, 1993, Volume: 42, Issue:2 Topics: Aspirin; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged;	1993
Plasma albumin concentration and diphenylhydantoin binding in man. Archives of neurology, 1975, Volume: 32, Issue:5 Topics: Adolescent; Adult; Aged; Aspirin; Blood Protein Electrophoresis; Blood-Brain Barrier; Chromatography	1975
[Prophylaxis and therapy of shunt thrombosis in terminal renal insufficiency (author's transl)]. Klinische Wochenschrift, 1977, Jan-15, Volume: 55, Issue:2 Topics: Anticoagulants; Arteriovenous Shunt, Surgical; Aspirin; Dextrans; Dipyridamole; Hemorrhagic Disorder	1977
[Analgesic nephropathy]. Medizinische Klinik, 1975, May-16, Volume: 70, Issue:20 Topics: Acidosis, Renal Tubular; Analgesics; Aspirin; Autopsy; Caffeine; Creatinine; Drug Interactions; Fema	1975
Uric acid: binding levels of urate ions in normal and uraemic plasma, and in human serum albumin. Biochemical pharmacology, 1975, Oct-15, Volume: 24, Issue:20 Topics: Aspirin; Blood Proteins; Humans; In Vitro Techniques; Protein Binding; Renal Dialysis; Serum Albumin	1975
Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition. The Journal of clinical investigation, 1987, Volume: 79, Issue:6 Topics: Acetylation; Adult; Aged; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase Inhibitors; Female	1987
Buccal mucosa bleeding times of healthy dogs and of dogs in various pathologic states, including thrombocytopenia, uremia, and von Willebrand's disease. American journal of veterinary research, 1987, Volume: 48, Issue:9 Topics: Animals; Aspirin; Bleeding Time; Blood Coagulation Tests; Dog Diseases; Dogs; Mouth Mucosa; Thromboc	1987
Determination of aspirin and salicylic acid in uremic patients' plasma using reversed-phase high-performance liquid chromatography. Therapeutic drug monitoring, 1987, Volume: 9, Issue:2 Topics: Aspirin; Chromatography, High Pressure Liquid; Humans; Salicylates; Salicylic Acid; Uremia	1987
Aspirin-induced hypoglycaemia in a patient on haemodialysis. Lancet (London, England), 1971, Nov-13, Volume: 2, Issue:7733 Topics: Adult; Aspirin; Chemical and Drug Induced Liver Injury; Humans; Hypoglycemia; Kidney Failure, Chroni	1971
Haemolytic-uraemic syndrome: thrombocyturia after treatment with streptokinase and aspirin. Lancet (London, England), 1972, Oct-07, Volume: 2, Issue:7780 Topics: Anemia, Hemolytic; Aspirin; Blood Cell Count; Blood Platelets; Child; Hematuria; Hemolytic-Uremic Sy	1972
Analgesic abuse in psychiatric patients. Lancet (London, England), 1970, Jun-20, Volume: 760, Issue:1 Topics: Adult; Aged; Anemia; Aspirin; Creatinine; Dyspepsia; Female; Humans; Kidney Diseases; Male; Mental D	1970
Evaluation of a quantitative platelet-collagen adhesiveness test system. Thrombosis research, 1974, Volume: 5, Issue:2 Topics: Aspirin; Chlorpromazine; Collagen; Dialysis; Dose-Response Relationship, Drug; Edetic Acid; Glutaral	1974
Platelet function tests in uraemia and under acetylsalicylic acid administration. Haemostasis, 1974, Volume: 3, Issue:3 Topics: Aspirin; Blood Platelet Disorders; Female; Humans; Male; Platelet Adhesiveness; Platelet Aggregation	1974
The bleeding time as a screening test for evaluation of platelet function. The New England journal of medicine, 1972, Jul-27, Volume: 287, Issue:4 Topics: Adult; Aspirin; Blood Cell Count; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets	1972
A kinetic evaluation of hemostasis in renal disease. The New England journal of medicine, 1974, Nov-21, Volume: 291, Issue:21 Topics: Aspirin; Blood Coagulation; Complement System Proteins; Diabetic Nephropathies; Dipyridamole; Fibrin	1974
Injury and repair in acute gastroduodenal ulceration. American journal of surgery, 1973, Volume: 125, Issue:1 Topics: Acute Disease; Aspirin; Burns; Cushing Syndrome; Duodenal Ulcer; Gastric Mucosa; Humans; Infections;	1973
Lysozymuria and acute disorders of renal function. Journal of clinical pathology, 1973, Volume: 26, Issue:4 Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo	1973
Haemolytic-uraemic syndrome in an adult with pericarditis and pleurisy. British medical journal, 1973, Jun-09, Volume: 2, Issue:5866 Topics: Adult; Alopecia; Anemia, Hemolytic; Aspirin; Dipyridamole; Female; Hemolytic-Uremic Syndrome; Hepari	1973
[Hemolytic-uremic syndrome and microangiopathic hemolytic anemia]. Recenti progressi in medicina, 1973, Volume: 54, Issue:1 Topics: Adrenal Cortex Hormones; Anemia, Hemolytic; Aspirin; Dextrans; Dipyridamole; Drug Hypersensitivity;	1973
[Hypercoagulability in patients treated with hemodialysis (diagnosis and therapy)]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1971, Volume: 77 Topics: Aspirin; Blood Coagulation Disorders; Blood Coagulation Factors; Humans; Platelet Adhesiveness; Rena	1971
Aspirin-induced prolongation of the ivy bleeding time. Its diagnostic usefulness. California medicine, 1971, Volume: 115, Issue:4 Topics: Aspirin; Blood Coagulation; Blood Coagulation Disorders; Blood Platelet Disorders; Humans; Time Fact	1971
Plasma protein binding of diphenylhydantoin in man. Acta pharmacologica et toxicologica, 1971, Volume: 29 Suppl 3 Topics: Adult; Aspirin; Bilirubin; Blood Proteins; Carbon Isotopes; Epilepsy; Female; Humans; Hydrogen-Ion C	1971
Analgesic nephropathy. A common form of renal disease in Australia. The Medical journal of Australia, 1969, Dec-06, Volume: 2, Issue:23 Topics: Acetaminophen; Analgesics; Anemia; Animals; Aspirin; Australia; Caffeine; Diagnosis, Differential; D	1969
Uremic toxins and platelet function. Archives of internal medicine, 1970, Volume: 126, Issue:5 Topics: Adenine Nucleotides; Animals; Aspirin; Blood Platelets; Creatinine; Guanidines; Humans; Mice; Phenol	1970
The occurrence and clinical features of analgesic abuse in Western Scotland. Scottish medical journal, 1968, Volume: 13, Issue:11 Topics: Adult; Aged; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Sideroblastic; Aspirin; Blood Urea Nitr	1968

aspirin and Uremia