Page last updated: 2024-10-23

aspirin and Ulcer

aspirin has been researched along with Ulcer in 88 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
"Aspirin use is associated with increased rates of marginal ulceration after RYGB."9.41Aspirin Use as a Risk Factor for Marginal Ulceration in Roux-en-Y Gastric Bypass Patients: A Meta-Analysis of 24,770 Patients. ( Clapp, B; Dayyeh, BA; Ghanem, OM; Hassan, O; Portela, RC; Sharma, I; Spaniolas, K; Vahibe, A, 2023)
"The Aspirin Myocardial Infarction Study (AMIS) was a multicenter, randomized, double-blind, placebo-controlled trial of 1."9.05The aspirin myocardial infarction study: final results. The Aspirin Myocardial Infarction Study research group. ( , 1980)
"Diclofenac sodium, a phenylacetic acid derivative, is a non-steroidal, anti-inflammatory, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions, and in the treatment of pain resulting from minor surgery, trauma and dysmenorrhoea."8.76Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980)
" Here, we describe a 3-year-old boy with typical KD who had lower gastrointestinal bleeding caused by rectal ulcers on the third day of aspirin therapy."7.96A case of rectal ulcers during aspirin therapy in acute Kawasaki disease. ( Han, Y; Hu, C; Yu, Y, 2020)
"With continued aspirin abuse, recurrent ulceration is the rule, and complications, especially stenosis, are common."7.70Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer. ( Hirschowitz, BI; Lanas, A, 1998)
"Aspirin, a common analgesic-antipyretic and anti-inflammatory drug, often induces gastric ulcer, but its pathogenesis remains unsettled."7.69Neuronal expression of FOS protein in the nucleus tractus solitarii and the dorsal motor nucleus of the vagus nerve after i.p. injection of ulcerogenic aspirin. ( Miura, M; Takahashi, A, 1995)
"Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats."7.67Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985)
"Although acetylsalicylic acid (aspirin) can cause acute damage to human gastric mucosa, its relationship to chronic gastric ulcer has been less documented."7.65Aspirin and gastric ulcer. ( Cameron, AJ, 1975)
"To assess the association of aspirin, clopidogrel, and their combination with gastrointestinal injury progression among patients without high bleeding risk after PCI."5.69Progression of Gastrointestinal Injury During Antiplatelet Therapy After Percutaneous Coronary Intervention: A Secondary Analysis of the OPT-PEACE Randomized Clinical Trial. ( Bao, D; Cui, M; Deng, J; Feng, J; Gao, W; Han, Y; Han, YL; He, C; Huang, YH; Jia, SB; Jiang, CM; Jiang, MN; Jiang, X; Li, JX; Li, Y; Li, ZS; Liao, Z; Ma, SC; Ma, SR; Ma, YT; Qiu, MH; Qu, P; Ru, LS; Sheng, JQ; Stone, GW; Tao, L; Wang, BM; Wang, JH; Wang, XY; Wang, XZ; Yang, K; Yang, SQ; Yang, YL; Zhang, WJ; Zhao, XX, 2023)
"Patients (n = 505) undergoing percutaneous coronary intervention in whom capsule endoscopy demonstrated no ulcerations or bleeding (although erosions were permitted) after 6 months of dual antiplatelet therapy (DAPT) were randomly assigned to aspirin plus placebo (n = 168), clopidogrel plus placebo (n = 169), or aspirin plus clopidogrel (n = 168) for an additional 6 months."5.51Magnetically Controlled Capsule Endoscopy for Assessment of Antiplatelet Therapy-Induced Gastrointestinal Injury. ( Bao, D; Cui, M; Deng, J; Feng, J; Gao, W; Han, Y; Huang, Y; Jia, S; Jiang, C; Li, J; Li, Y; Li, Z; Liao, Z; Ma, S; Ma, Y; Qiu, M; Qu, P; Ru, L; Sheng, J; Stone, GW; Tao, L; Wang, B; Wang, J; Wang, X; Yang, K; Yang, S; Yang, Y; Zhang, W; Zhao, X, 2022)
"Aspirin use is associated with increased rates of marginal ulceration after RYGB."5.41Aspirin Use as a Risk Factor for Marginal Ulceration in Roux-en-Y Gastric Bypass Patients: A Meta-Analysis of 24,770 Patients. ( Clapp, B; Dayyeh, BA; Ghanem, OM; Hassan, O; Portela, RC; Sharma, I; Spaniolas, K; Vahibe, A, 2023)
" pylori infection, use or abuse (often surreptitious) of high dose non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin (ASA) are the two major causes of true refractory ulcers."5.41Advances in the pharmacotherapeutic management of refractory peptic ulcers. ( Borao Laguna, C; Lanas, A, 2023)
" Large erosions or ulcers were observed in 12 (60%; 95% confidence interval 36%- 80%) aspirin users."5.14Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage. ( Fujita, M; Graham, DY; Haruma, K; Hata, J; Honda, K; Kamada, T; Kusunoki, H; Nishi, R; Shiotani, A, 2010)
"Eleven patients who developed gastric ulcers while undergoing low-dose enteric-coated aspirin therapy were enrolled."5.13Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study. ( Arakawa, T; Fujiwara, Y; Higuchi, K; Kameda, N; Machida, H; Okazaki, H; Oshitani, N; Sugimori, S; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T, 2008)
"The Aspirin Myocardial Infarction Study (AMIS) was a multicenter, randomized, double-blind, placebo-controlled trial of 1."5.05The aspirin myocardial infarction study: final results. The Aspirin Myocardial Infarction Study research group. ( , 1980)
"Moderate-certainty evidence suggests that intravenous iloprost (prostacyclin analogue) is more effective than aspirin for eradicating rest pain and healing ischaemic ulcers in Buerger's disease, but oral iloprost is not more effective than placebo."5.05Pharmacological treatment for Buerger's disease. ( Baptista-Silva, JC; Cacione, DG; do Carmo Novaes, F; Macedo, CR, 2020)
"Moderate quality evidence suggests that intravenous iloprost (prostacyclin analogue) is more effective than aspirin for eradicating rest pain and healing ischaemic ulcers in Buerger's disease, but oral iloprost is not more effective than placebo."4.93Pharmacological treatment for Buerger's disease. ( Baptista-Silva, JC; Cacione, DG; Macedo, CR, 2016)
"Moderate quality evidence suggests that intravenous iloprost (prostacyclin analogue) is more effective than aspirin for eradicating rest pain and healing ischaemic ulcers in Buerger's disease, but oral iloprost is not more effective than placebo."4.93Pharmacological treatment for Buerger's disease. ( Baptista-Silva, JC; Cacione, DG; Macedo, CR, 2016)
"The use of low-dose aspirin (LDA) is well known to be associated with an increased risk of serious upper gastrointestinal complications, such as peptic ulceration and bleeding."4.91Small bowel injury in low-dose aspirin users. ( Endo, H; Higurashi, T; Kato, T; Nakajima, A; Ohkubo, H; Sakai, E; Umezawa, S, 2015)
"Ulcer complications associated with the use of NSAIDs, in high-risk patients, are often caused by a failure to identify patients' risk factors, concomitant use of aspirin or multiple NSAIDs, and underutilization of gastroprotective agents."4.83Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks. ( Chan, FK, 2006)
"This review examines ulcers and gastrointestinal bleeding with low-dose aspirin, focusing on randomized placebo-controlled trials."4.83Review article: gastrointestinal bleeding with low-dose aspirin - what's the risk? ( Laine, L, 2006)
"Diclofenac sodium, a phenylacetic acid derivative, is a non-steroidal, anti-inflammatory, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and allied conditions, and in the treatment of pain resulting from minor surgery, trauma and dysmenorrhoea."4.76Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980)
"This cohort study demonstrated that regular aspirin use was associated with a reduced risk of liver disease in men without an elevated risk of gastrointestinal bleeding or ulcers."4.31Aspirin is associated with a reduced incidence of liver disease in men. ( Alqahtani, S; Creasy, KT; Hehl, L; Krishnan, A; Rader, DJ; Rendel, MD; Schneider, CV; Schneider, KM; Scorletti, E; Seeling, KS; Serper, M; Trautwein, C; Vell, MS; Vujkovic, M; Wangensteen, K; Zandvakili, I, 2023)
" Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively."4.12Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models. ( Ahsan, H; Anjum, I; Ismail, S; Kahrizi, D; Movafagh, A; Naveed Mushtaq, M; Ramzan, HM; Razzaq, A; Shabbir, U; Shoukat, A, 2022)
"To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO."4.02Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO). ( Gao, J; Huang, L; Wang, J, 2021)
"The use of low-dose aspirin may aggravate the severity and mask the symptoms of abdominal pain in ischemic colitis."3.96Low-dose aspirin and the severity of ıschemic colitis: A single-center retrospective study. ( Deng, B; Ding, Y; Gong, W; Lu, G; Wang, Y; Wu, D; Wu, K; Xiao, W; Zhou, SY, 2020)
" Here, we describe a 3-year-old boy with typical KD who had lower gastrointestinal bleeding caused by rectal ulcers on the third day of aspirin therapy."3.96A case of rectal ulcers during aspirin therapy in acute Kawasaki disease. ( Han, Y; Hu, C; Yu, Y, 2020)
"96) as well as history of hematemesis, melena in the past 30 days, positive nasogastric aspirate, prior upper gastrointestinal bleeding or use of aspirin or non-steroidal anti-inflammatory."3.83Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. ( Camus, M; Dulai, GS; Ghassemi, KA; Jensen, DM; Jutabha, R; Khungar, V; Kovacs, TO; Machicado, GA; Ohning, GV, 2016)
" Factors reported to modify systemic inflammation (low vitamin D levels, high body mass index, use of aspirin or nonsteroidal anti-inflammatory drugs or smoking were tested as predictors of microscopic ulceration (in which primary tumors are inflamed) and melanoma-specific survival (MSS)."3.8125-Hydroxyvitamin D2 /D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort. ( Bishop, DT; Chan, M; Davies, JR; Gascoyne, J; Haynes, S; Latheef, F; Newton-Bishop, JA; O'Donovan, C; Randerson-Moor, J; Waseem, S, 2015)
"Chronic constipation, enteric-coated aspirin intake and splanchnic atherosclerosis are risk factors related to ulcer in IC patients."3.80[An analysis of clinical characteristics and risk factors for ulceration in ischemic colitis]. ( Li, X; Liao, L; Liu, W; Liu, Y; Shi, H; Wu, B, 2014)
"ASP6537 functions as a highly selective COX-1 inhibitor with a superior ability to aspirin for normalizing TXA2/PGI2 balance, and exerts antithrombotic effect without ulcerogenic effect."3.79ASP6537, a novel highly selective cyclooxygenase-1 inhibitor, exerts potent antithrombotic effect without "aspirin dilemma". ( Abe, M; Funatsu, T; Kato, Y; Kawasaki, T; Morita, Y; Ohmiya, M; Okada, M; Sakata, C; Suzuki, K, 2013)
" Derivatives 4a, 4b and 4c exhibited moderate to good anti-inflammatory and analgesic activity in carrageenan-induced rat paw edema and acetic acid-induced writhing in mice, respectively, with low ulcerogenicity compared with the standard drug indomethacin."3.76Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. ( Gaba, M; Gaba, P; Sharma, V; Singh, D; Singh, S, 2010)
"We present a case of severe lower gastrointestinal bleeding due to appendiceal ulcer associated with intake of enteric coated aspirin."3.73[Active lower gastrointestinal bleeding due to appendiceal ulcer]. ( de Sola-Earle, C; Fernández-Moreno, N; Montiel Quezel-Guerraz, N; Palma-Carazo, F; Rivera-Irigoín, R, 2005)
"With continued aspirin abuse, recurrent ulceration is the rule, and complications, especially stenosis, are common."3.70Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer. ( Hirschowitz, BI; Lanas, A, 1998)
"Data from the medical treatment group of the Aspirin in TIA study were reviewed, and prospective analysis of patients with asymptomatic bruits was performed to see whether carotid stenosis (0 to 49% or 50 to 99%) or ulceration produced an increased risk of ipsilateral TIA or infarct."3.67The significance of carotid stenosis or ulceration. ( Bigelow, RH; Fields, WS; Grotta, JC; Hankins, L; Hu, H, 1984)
"Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats."3.67Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985)
" In carrageenin-induced oedema indoprofen and prednisolone had a synergistic anti-inflammatory effect, and indoprofen and acetylsalicylic acid showed an additive effect."3.66Preclinical studies on indoprofen, a new non-steroidal analgesic-antiinflammatory agent. ( Buttinoni, A; Tommasini, R, 1981)
"Although acetylsalicylic acid (aspirin) can cause acute damage to human gastric mucosa, its relationship to chronic gastric ulcer has been less documented."3.65Aspirin and gastric ulcer. ( Cameron, AJ, 1975)
"Acute gastroduodenal ulcer bleeding is a life-threatening condition."1.91[Recent aspects of pharmaceutical and endoscopic treatment of acute gastroduodenal ulcer bleeding]. ( Rácz, I, 2023)
"These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment."1.42Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study. ( Chang, DK; Cheon, JH; Choi, MG; Chun, HJ; Jang, BI; Jeen, YT; Jeon, SR; Jeon, SW; Kim, JH; Kim, JO; Kim, JS; Lee, KJ; Lim, YJ; Moon, JS; Park, CH; Shim, KN; Song, EM; Song, HJ; Ye, BD, 2015)
"Complications of Zenker's diverticulum are rare and include ulcer, bleeding and malignancy."1.33Ulcer in the basis of Zenker's diverticulum mimicking esophageal malignancy. ( Ataseven, H; Basar, O; Ertugrul, I; Odemis, B; Turhan, N; Yüksel, O, 2006)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199024 (27.27)18.7374
1990's7 (7.95)18.2507
2000's22 (25.00)29.6817
2010's18 (20.45)24.3611
2020's17 (19.32)2.80

Authors

AuthorsStudies
Khanum, SA3
D, VT1
Shashikanth, S2
Firdouse, A2
Sharma, M2
Ray, SM2
Venu, TD1
Manuprasad, BK1
Mohamed, R1
Vishwanth, BS1
Khanum, NF1
Shashikanth, M1
Aytaç, SP1
Tozkoparan, B1
Kaynak, FB1
Aktay, G1
Göktaş, O1
Unüvar, S1
Gaba, M1
Singh, D1
Singh, S1
Sharma, V1
Gaba, P1
Abdelall, EK1
Kamel, GM1
Han, Y4
Liao, Z2
Li, Y4
Zhao, X1
Ma, S2
Bao, D2
Qiu, M1
Deng, J2
Wang, J2
Qu, P2
Jiang, C1
Jia, S1
Yang, S1
Ru, L1
Feng, J2
Gao, W2
Huang, Y1
Tao, L2
Yang, K2
Wang, X2
Zhang, W1
Wang, B1
Yang, Y1
Li, J1
Sheng, J1
Ma, Y1
Cui, M2
Li, Z1
Stone, GW2
Ajuka Obasi, N1
Aloke, C1
Obasi, SE1
Ogbonnia Egwu, C1
Clement Famurewa, A1
Nkemjika Ogbu, P1
Rahman, K1
Ali, G1
Khan, R1
Khan, I1
Ali, I1
Mosa, OF1
Ahmed, A1
Ayaz, M1
Nawaz, A1
Murthy, HCA1
Portela, RC1
Sharma, I1
Vahibe, A1
Hassan, O1
Spaniolas, K1
Dayyeh, BA1
Clapp, B1
Ghanem, OM1
Kinoshita, Y1
Kato, M1
Sugizaki, K1
Ikeuchi, S1
Koggel, LM1
Lantinga, MA1
Büchner, FL1
Drenth, JPH1
Frankema, JS1
Heeregrave, EJ1
Heringa, M1
Numans, ME1
Siersema, PD1
Ajaib, M1
Ishtiaq, S1
Ishtiaq, M1
Maqbool, M1
Bhatti, KH1
Khan, A1
Afreen, A1
Hussain, T1
Sardar, T1
Gul, A1
Azeem, M1
Borao Laguna, C1
Lanas, A2
Ismail, S1
Naveed Mushtaq, M1
Shabbir, U1
Razzaq, A1
Ramzan, HM1
Shoukat, A1
Ahsan, H1
Movafagh, A1
Kahrizi, D1
Anjum, I1
Rácz, I1
Vell, MS1
Krishnan, A1
Wangensteen, K1
Serper, M1
Seeling, KS1
Hehl, L1
Rendel, MD1
Zandvakili, I1
Vujkovic, M1
Scorletti, E1
Creasy, KT1
Trautwein, C1
Rader, DJ1
Alqahtani, S1
Schneider, KM1
Schneider, CV1
He, C1
Jiang, X1
Jiang, MN1
Zhao, XX1
Ma, SR1
Qiu, MH1
Wang, JH1
Jiang, CM1
Jia, SB1
Yang, SQ1
Ru, LS1
Huang, YH1
Wang, XY1
Zhang, WJ1
Wang, BM1
Yang, YL1
Li, JX1
Sheng, JQ1
Ma, YT1
Ma, SC1
Wang, XZ1
Li, ZS1
Han, YL1
Hu, C1
Yu, Y1
Cacione, DG3
Macedo, CR3
do Carmo Novaes, F1
Baptista-Silva, JC3
Gao, J1
Huang, L1
Xiao, W1
Zhou, SY1
Wu, K1
Deng, B1
Wu, D1
Wang, Y1
Gong, W1
Ding, Y1
Lu, G1
Chi, T1
Zhao, Q1
Wang, P1
Rockall, TA1
Ota, K1
Takeuchi, T1
Kojima, Y1
Harada, S1
Hirata, Y1
Sugawara, N1
Nouda, S1
Kakimoto, K1
Kuramoto, T1
Higuchi, K2
Mortensen, B1
Murphy, C1
O'Grady, J1
Lucey, M1
Elsafi, G1
Barry, L1
Westphal, V1
Wellejus, A1
Lukjancenko, O1
Eklund, AC1
Nielsen, HB1
Baker, A1
Damholt, A1
van Hylckama Vlieg, JET1
Shanahan, F1
Buckley, M1
Sakata, C1
Kawasaki, T1
Kato, Y1
Abe, M1
Suzuki, K2
Ohmiya, M1
Funatsu, T1
Morita, Y1
Okada, M1
Ehrhard, F1
Nazeyrollas, P1
Brixi, H1
Heurgue-Berlot, A1
Thiéfin, G1
Liu, W1
Liao, L1
Shi, H1
Wu, B1
Li, X1
Liu, Y1
Newton-Bishop, JA1
Davies, JR1
Latheef, F1
Randerson-Moor, J1
Chan, M1
Gascoyne, J1
Waseem, S1
Haynes, S1
O'Donovan, C1
Bishop, DT1
Shim, KN1
Song, EM1
Jeen, YT1
Kim, JO1
Jeon, SR1
Chang, DK1
Song, HJ1
Lim, YJ1
Kim, JS1
Ye, BD1
Park, CH1
Jeon, SW1
Cheon, JH1
Lee, KJ1
Kim, JH1
Jang, BI1
Moon, JS1
Chun, HJ1
Choi, MG1
Endo, H1
Sakai, E1
Kato, T1
Umezawa, S1
Higurashi, T1
Ohkubo, H1
Nakajima, A2
Lee, JY1
Moon, IT1
Lee, HY1
Lee, HL1
Han, DS1
Camus, M1
Khungar, V1
Jensen, DM1
Ohning, GV1
Kovacs, TO1
Jutabha, R1
Ghassemi, KA1
Machicado, GA1
Dulai, GS1
Abdellatif, KR1
Fadaly, WA1
Azouz, AA1
Schmidtko, J1
Truninger, K1
Gugger, M1
Cottagnoud, P1
Stucki, A1
Watanabe, T1
Sugimori, S1
Kameda, N1
Machida, H1
Okazaki, H1
Tanigawa, T1
Watanabe, K1
Tominaga, K1
Fujiwara, Y1
Oshitani, N1
Arakawa, T2
Hara, H1
Sekino, Y1
Akimoto, K1
Tomimoto, A1
Akiyama, T1
Fujisawa, N1
Saito, K1
Inamori, M1
Kubota, K1
Nakamura, A1
Saito, S1
Koyama, S1
Kawai, T1
Yamagishi, T1
Goto, S1
Shiotani, A2
Haruma, K2
Nishi, R1
Fujita, M2
Kamada, T2
Honda, K2
Kusunoki, H1
Hata, J1
Graham, DY2
Preobrazhenskiĭ, DV1
Sidorenko, BA1
Batyraliev, TA1
Vural, A1
Islek, M1
Avsar, O1
Fettser, DV1
Murao, T1
Ishii, M1
Matsumoto, H1
Tarumi, K1
Sakakibara, T1
Guda, N1
Vakil, N1
Sawhney, MS1
Nelson, DB1
LISH, PM1
DUNGAN, KW1
ROBBINS, SR1
TUFFANELLI, DL1
DUBOIS, EL1
LEVRAT, M1
PASQUIER, J1
MARTIN, F1
TRUCHOT, R1
MUIR, A1
COSSAR, IA1
Rivera-Irigoín, R1
de Sola-Earle, C1
Palma-Carazo, F1
Montiel Quezel-Guerraz, N1
Fernández-Moreno, N1
Abdel-Rahman, HM1
Hussein, MA1
Odemis, B1
Ataseven, H1
Basar, O1
Ertugrul, I1
Yüksel, O1
Turhan, N1
Laine, L1
Chan, FK1
Grotta, JC1
Bigelow, RH1
Hu, H1
Hankins, L1
Fields, WS1
Brogden, RN1
Heel, RC1
Pakes, GE1
Speight, TM1
Avery, GS1
Whittle, BJ1
Buttinoni, A1
Tommasini, R1
Chono, S1
Yamada, H1
Nakamura, H1
Kobayashi, K1
Colin-Jones, DG1
Holsapple, MP1
Yim, GK1
Takahashi, A1
Miura, M1
Rodinó, S1
Saccá, N1
De Medici, A1
Giglio, A1
Diethrich, EB1
Ndiaye, M1
Reid, DB1
Van Nieuwenhove, K1
Van Herreweghe, I1
Haentjens, M1
Pipeleers-Marichal, M1
van Vandenplas, Y1
Somasundaram, S1
Rafi, S1
Hayllar, J1
Sigthorsson, G1
Jacob, M1
Price, AB1
Macpherson, A1
Mahmod, T1
Scott, D1
Wrigglesworth, JM1
Bjarnason, I1
Hirschowitz, BI1
Martín Fernández, J1
García Rojo, M1
Rodríguez Sánchez, E1
Ramia Angel, JM1
Cubo Cintas, T1
Hernández Calvo, J1
Kehrer, G1
Bosseckert, H1
Koppe, P1
Lutz, B1
Will, U1
Zinsser, E1
Vincent, L1
Frappaz, A1
Cousin, F1
Sauret, V1
Pacheco, Y1
Nicolas, JF1
Sicot, C1
Tamura, T1
Cameron, AJ1
Niemegeers, CJ1
Lenaerts, FM1
Awouters, F1
Janssen, PA1
Uribe, A1
Johansson, C1
Slezak, P1
Rubio, C1
Schreiber, JB1
Covington, JA1
Long, JB1
Lynch, TG1
Karanfilian, RG1
Hobson, RW1
Ezer, E1
Claman, HN1
Coldwell, BB1
Boyd, EM1
Stafford, ES1
Zuidema, GD1
Cameron, JL1
Adams, SS1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
COmparison of Mono- Versus Dual antiPlatelet Therapy During 6-12 Months After New Generation Drug Eluting Stent Implantation for Prevention of Gastrointestinal Injury Evaluated by Ankon Magnetically Controlled Capsule Endoscopy[NCT03198741]Phase 4783 participants (Actual)Interventional2017-07-13Completed
The Effect of 8 Weeks Intake of a Probiotic Strain on a 6 Week Aspirin-induced Intestinal Deterioration Challenge in Healthy Volunteers - a Randomized, Double-blind, Placebo-controlled, Two Armed, Parallel Group Trial.[NCT03228589]Phase 2109 participants (Actual)Interventional2017-07-15Completed
Sclerotherapy With Polidocanol Foam in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease in Patients With Liver Cirrhosis: A Prospective, Cohort Trial[NCT05807425]Phase 2/Phase 340 participants (Anticipated)Interventional2023-03-31Recruiting
Video Capsule Endoscopy for Lesion Localization and Diagnosis in Patients With Severe Hematochezia[NCT03616041]50 participants (Anticipated)Observational2021-02-10Recruiting
[NCT00000491]Phase 30 participants Interventional1974-10-31Completed
Evaluation of Neurological Outcome in Patients Undergoing Cerebral Angiography and Revascularization Using Angioplasty and Stent-Supported Angioplasty[NCT00597974]108 participants (Actual)Observational2003-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

12 reviews available for aspirin and Ulcer

ArticleYear
Aspirin Use as a Risk Factor for Marginal Ulceration in Roux-en-Y Gastric Bypass Patients: A Meta-Analysis of 24,770 Patients.
    The American surgeon, 2023, Volume: 89, Issue:6

    Topics: Aspirin; Gastric Bypass; Humans; Obesity, Morbid; Retrospective Studies; Risk Factors; Ulcer

2023
Advances in the pharmacotherapeutic management of refractory peptic ulcers.
    Expert opinion on pharmacotherapy, 2023, Volume: 24, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Helicobacter pylori; Huma

2023
Pharmacological treatment for Buerger's disease.
    The Cochrane database of systematic reviews, 2020, 05-04, Volume: 5

    Topics: Adult; Alprostadil; Amputation, Surgical; Aspirin; Epoprostenol; Folic Acid; Hematinics; Humans; Ilo

2020
Small bowel injury in low-dose aspirin users.
    Journal of gastroenterology, 2015, Volume: 50, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capsule Endoscopy; Drug Administration Schedule; G

2015
Pharmacological treatment for Buerger's disease.
    The Cochrane database of systematic reviews, 2016, Feb-01, Volume: 2

    Topics: Alprostadil; Amputation, Surgical; Aspirin; Epoprostenol; Humans; Iloprost; Prostaglandins; Randomiz

2016
Pharmacological treatment for Buerger's disease.
    The Cochrane database of systematic reviews, 2016, Mar-11, Volume: 3

    Topics: Adult; Alprostadil; Amputation, Surgical; Aspirin; Epoprostenol; Humans; Iloprost; Male; Middle Aged

2016
[Thienopyridines in the treatment and prevention of cardiovascular diseases. III. therapeutic application of clopidogrel as monotherapy (without acetylsalicylic acid)].
    Kardiologiia, 2009, Volume: 49, Issue:12

    Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platel

2009
Review article: gastrointestinal bleeding with low-dose aspirin - what's the risk?
    Alimentary pharmacology & therapeutics, 2006, Sep-15, Volume: 24, Issue:6

    Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Ca

2006
Primer: managing NSAID-induced ulcer complications--balancing gastrointestinal and cardiovascular risks.
    Nature clinical practice. Gastroenterology & hepatology, 2006, Volume: 3, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Contraindications; Cycloo

2006
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
    Drugs, 1980, Volume: 20, Issue:1

    Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact

1980
[Digestive complications of corticoid treatment].
    La Revue du praticien, 1975, Mar-11, Volume: 25, Issue:15

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aspirin; Colonic Diseases; Duodenal Ulcer; Eso

1975
Asymptomatic carotid disease.
    Surgery, gynecology & obstetrics, 1985, Volume: 160, Issue:1

    Topics: Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular Disor

1985

Trials

9 trials available for aspirin and Ulcer

ArticleYear
Magnetically Controlled Capsule Endoscopy for Assessment of Antiplatelet Therapy-Induced Gastrointestinal Injury.
    Journal of the American College of Cardiology, 2022, 01-18, Volume: 79, Issue:2

    Topics: Aged; Aspirin; Capsule Endoscopy; Clopidogrel; Dual Anti-Platelet Therapy; Female; Gastric Mucosa; G

2022
Progression of Gastrointestinal Injury During Antiplatelet Therapy After Percutaneous Coronary Intervention: A Secondary Analysis of the OPT-PEACE Randomized Clinical Trial.
    JAMA network open, 2023, Nov-01, Volume: 6, Issue:11

    Topics: Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneo

2023
Preventive effect of ecabet sodium on low-dose aspirin-induced small intestinal mucosal injury: a randomized, double-blind, pilot study.
    BMC gastroenterology, 2019, Jan-08, Volume: 19, Issue:1

    Topics: Abietanes; Adult; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Double-Blind Method; Female; Humans

2019
Bifidobacteriumbreve Bif195 Protects Against Small-Intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers.
    Gastroenterology, 2019, Volume: 157, Issue:3

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bifidobacterium breve; Capsule

2019
Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2008, Volume: 6, Issue:11

    Topics: Aged; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Female; Humans; Intestine, Small; Male; Middle

2008
Circadian variations of gastrointestinal mucosal damage detected with transnasal endoscopy in apparently healthy subjects treated with low-dose aspirin (ASA) for a short period.
    Journal of atherosclerosis and thrombosis, 2009, Volume: 16, Issue:3

    Topics: Adult; Alanine; Aspirin; Circadian Rhythm; Double-Blind Method; Endoscopy; Female; Gastric Mucosa; H

2009
Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage.
    Scandinavian journal of gastroenterology, 2010, Volume: 45, Issue:3

    Topics: Adult; Anti-Ulcer Agents; Aspirin; Diterpenes; Double-Blind Method; Female; Humans; Intestine, Small

2010
The aspirin myocardial infarction study: final results. The Aspirin Myocardial Infarction Study research group.
    Circulation, 1980, Volume: 62, Issue:6 Pt 2

    Topics: Aspirin; Cardiovascular Diseases; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Male

1980
Asymptomatic carotid disease.
    Surgery, gynecology & obstetrics, 1985, Volume: 160, Issue:1

    Topics: Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Carotid Artery Diseases; Cerebrovascular Disor

1985

Other Studies

68 other studies available for aspirin and Ulcer

ArticleYear
Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Cyclooxygenase Inhibitors; In Vitro Tec

2004
Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:10

    Topics: Acetates; Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri

2008
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability.
    Bioorganic & medicinal chemistry letters, 2007, Dec-15, Volume: 17, Issue:24

    Topics: Acetates; Amides; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cytochrome

2007
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
    Bioorganic & medicinal chemistry letters, 2008, Aug-01, Volume: 18, Issue:15

    Topics: Algorithms; Animals; Animals, Inbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Disease Model

2008
Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines.
    Bioorganic & medicinal chemistry letters, 2008, Aug-15, Volume: 18, Issue:16

    Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chemistry, Pharmaceutical; Drug Design; Edema; Ethan

2008
Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Edema; Female; Male; Mice;

2009
Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Edema; Male; Mice; Rats;

2010
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.
    European journal of medicinal chemistry, 2016, Aug-08, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Cattle; Celecoxib; C

2016
Protective effects of Dialium guineense pulp on aspirin-induced gastric mucosal injury in albino rats.
    Journal of applied biomedicine, 2021, Volume: 19, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Fabaceae; Gastric Mucosa; Humans; Plant Extracts;

2021
Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Car

2022
Rabeprazole Coadministration Controls Ulcer Recurrence in Patients on Low-dose Aspirin Therapy: A Multicenter Prospective Study.
    Internal medicine (Tokyo, Japan), 2023, Feb-15, Volume: 62, Issue:4

    Topics: Anti-Ulcer Agents; Aspirin; Humans; Peptic Ulcer; Prospective Studies; Rabeprazole; Ulcer

2023
Predictors for inappropriate proton pump inhibitor use: observational study in primary care.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2022, Volume: 72, Issue:725

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Male; Middle Ag

2022
Analysis of antidiabetic, antiulcer and analgesic potential of traditional ethnomedicinal plant Emex spinosa (L.) Campd. from Azad Jammu and Kashmir.
    PloS one, 2022, Volume: 17, Issue:10

    Topics: Analgesics; Animals; Anti-Ulcer Agents; Aspirin; Blood Glucose; Ethanol; Flavonoids; Formaldehyde; H

2022
Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.
    Cellular and molecular biology (Noisy-le-Grand, France), 2022, Sep-30, Volume: 68, Issue:10

    Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Chemical and Drug Induced Liver In

2022
[Recent aspects of pharmaceutical and endoscopic treatment of acute gastroduodenal ulcer bleeding].
    Orvosi hetilap, 2023, Jun-11, Volume: 164, Issue:23

    Topics: Aspirin; Endoscopy, Gastrointestinal; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pharmaceutical

2023
Aspirin is associated with a reduced incidence of liver disease in men.
    Hepatology communications, 2023, 10-01, Volume: 7, Issue:10

    Topics: Aspirin; Cohort Studies; Fatty Liver; Female; Gastrointestinal Hemorrhage; Humans; Incidence; Liver

2023
A case of rectal ulcers during aspirin therapy in acute Kawasaki disease.
    Pediatric rheumatology online journal, 2020, Mar-17, Volume: 18, Issue:1

    Topics: Aspirin; Child, Preschool; Colitis; Gastrointestinal Hemorrhage; Humans; Male; Mucocutaneous Lymph N

2020
Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO).
    Current vascular pharmacology, 2021, Volume: 19, Issue:6

    Topics: Anticoagulants; Aspirin; C-Reactive Protein; Gangrene; Heparin, Low-Molecular-Weight; Humans; Inflam

2021
Low-dose aspirin and the severity of ıschemic colitis: A single-center retrospective study.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2020, Volume: 31, Issue:12

    Topics: Abdominal Pain; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis, Ischemic; Colon; Co

2020
Fecal 16S rRNA Gene Sequencing Analysis of Changes in the Gut Microbiota of Rats with Low-Dose Aspirin-Related Intestinal Injury.
    BioMed research international, 2021, Volume: 2021

    Topics: Animals; Aspirin; Biodiversity; Cluster Analysis; Dose-Response Relationship, Drug; Feces; Gastroint

2021
Misoprostol for NSAID-induced small bowel erosions and ulcers.
    The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Humans; Misoprostol; Ulcer

2018
ASP6537, a novel highly selective cyclooxygenase-1 inhibitor, exerts potent antithrombotic effect without "aspirin dilemma".
    Thrombosis research, 2013, Volume: 132, Issue:1

    Topics: Animals; Aspirin; Carotid Artery Thrombosis; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epoprosten

2013
Proximal predominance of small bowel injury associated with uncoated low-dose aspirin therapy: a video capsule study in chronic users.
    European journal of gastroenterology & hepatology, 2013, Volume: 25, Issue:11

    Topics: Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Anti-Inflammatory Agents, Non-Steroidal; Anticoagu

2013
[An analysis of clinical characteristics and risk factors for ulceration in ischemic colitis].
    Zhonghua nei ke za zhi, 2014, Volume: 53, Issue:8

    Topics: Aged; Aspirin; Colitis, Ischemic; Constipation; Female; Gastrointestinal Hemorrhage; Hospitalization

2014
25-Hydroxyvitamin D2 /D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort.
    International journal of cancer, 2015, Jun-15, Volume: 136, Issue:12

    Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ste

2015
Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study.
    Gut and liver, 2015, Nov-23, Volume: 9, Issue:6

    Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capsule Endoscopy; Female; Huma

2015
Successful Management of Recurrent Colon Ulcer in Hemodialysis Patient after Conversion to Peritoneal Dialysis.
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2015, Volume: 66, Issue:6

    Topics: Aspirin; Colon; Colonic Diseases; Colonoscopy; Drug Therapy, Combination; Gastrointestinal Hemorrhag

2015
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
    Digestive diseases and sciences, 2016, Volume: 61, Issue:9

    Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont

2016
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
    Digestive diseases and sciences, 2016, Volume: 61, Issue:9

    Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont

2016
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
    Digestive diseases and sciences, 2016, Volume: 61, Issue:9

    Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont

2016
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
    Digestive diseases and sciences, 2016, Volume: 61, Issue:9

    Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont

2016
Synthesis, Cyclooxygenase Inhibition, Anti-Inflammatory Evaluation, and Ulcerogenic Liability of New 1,3,5-Triarylpyrazoline Derivatives Possessing a Methanesulfonyl Pharmacophore.
    Archiv der Pharmazie, 2016, Volume: 349, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Isoenzymes; Pyrazo

2016
[What is your diagnosis? Diaphragma disease].
    Praxis, 2008, Feb-06, Volume: 97, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Diseases; Diagnosis, Differential; Diclofe

2008
Colonic ulcers in a patient taking low-dose aspirin.
    Digestion, 2009, Volume: 79, Issue:4

    Topics: Aspirin; Colonic Diseases; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ulcer

2009
Combination of low-dose aspirin and thienopyridine exacerbates small bowel injury.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:3

    Topics: Aged; Aged, 80 and over; Aspirin; Capsule Endoscopy; Clopidogrel; Drug Therapy, Combination; Female;

2011
Heart Beat: Treating an ulcer may make aspirin okay.
    Harvard heart letter : from Harvard Medical School, 2002, Volume: 13, Issue:1

    Topics: Aspirin; Heart Rate; Humans; Ulcer

2002
Low-dose aspirin: protection from the panacea.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:12

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;

2002
An aspirin a day keeps the cardiologist away (but what about the gastroenterologist?).
    Gastroenterology, 2003, Volume: 124, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Dru

2003
Gastrointestinal pharmacology of antipyretic-analgetic agents. I. Effects on acid secretion and ulcer formation in the Shay rat.
    Archives internationales de pharmacodynamie et de therapie, 1959, Apr-01, Volume: 119, Issue:3-4

    Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Gastric Juice; Peptic Ulcer; P

1959
CUTANEOUS MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS.
    Archives of dermatology, 1964, Volume: 90

    Topics: Adrenal Cortex Hormones; Alopecia; Anti-Bacterial Agents; Antimalarials; Aspirin; Blister; Drug Erup

1964
[MEDICINAL ULCERS OF THE GREATER CURVATURE OF THE STOMACH].
    Archives des maladies de l'appareil digestif et des maladies de la nutrition, 1965, Volume: 54

    Topics: Adrenal Cortex Hormones; Aspirin; Drug Therapy; Radiography; Stomach Ulcer; Toxicology; Ulcer

1965
Aspirin and ulcer.
    British medical journal, 1955, Jul-02, Volume: 2, Issue:4930

    Topics: Aspirin; Humans; Peptic Ulcer; Stomach; Ulcer

1955
[Active lower gastrointestinal bleeding due to appendiceal ulcer].
    Gastroenterologia y hepatologia, 2005, Volume: 28, Issue:8

    Topics: Appendectomy; Appendix; Aspirin; Cecal Diseases; Colonoscopy; Combined Modality Therapy; Erythrocyte

2005
Synthesis of beta-hydroxypropanoic acid derivatives as potential anti-inflammatory, analgesic and antimicrobial agents.
    Archiv der Pharmazie, 2006, Volume: 339, Issue:7

    Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Aspergillus

2006
Ulcer in the basis of Zenker's diverticulum mimicking esophageal malignancy.
    Journal of the National Medical Association, 2006, Volume: 98, Issue:7

    Topics: Aged; Alcohol Drinking; Aspirin; Diagnosis, Differential; Diverticulitis; Endoscopy; Esophageal Neop

2006
Risk of low-dose aspirin: emphasis on outliers undermines the credibility of the conclusions.
    Alimentary pharmacology & therapeutics, 2007, Feb-01, Volume: 25, Issue:3

    Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Ca

2007
The significance of carotid stenosis or ulceration.
    Neurology, 1984, Volume: 34, Issue:4

    Topics: Angiography; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Cerebral Infarction; Fem

1984
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.
    Gastroenterology, 1981, Volume: 80, Issue:1

    Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Indomethacin; Intestinal Diseases; Male;

1981
Preclinical studies on indoprofen, a new non-steroidal analgesic-antiinflammatory agent.
    European journal of rheumatology and inflammation, 1981, Volume: 4, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Do

1981
[The role of endogenous prostaglandin in drug-induced gastrointestinal lesions--comparison of aspirin and indomethacin (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1981, Dec-01, Volume: 78, Issue:12

    Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Diseases; Intestinal Mucosa

1981
Drug-induced gastrointestinal ulceration: a review.
    Journal of the Royal Society of Medicine, 1980, Volume: 73, Issue:1

    Topics: Anti-Inflammatory Agents; Aspirin; Esophageal Diseases; Gastrointestinal Hemorrhage; Humans; Peptic

1980
Decreased gastrointestinal ulcerogenicity of chlordimeform, a basic anti-inflammatory agent.
    Toxicology and applied pharmacology, 1981, Jun-15, Volume: 59, Issue:1

    Topics: Amidines; Animals; Anti-Inflammatory Agents; Aspirin; Chlorphenamidine; Intestinal Diseases; Male; R

1981
Neuronal expression of FOS protein in the nucleus tractus solitarii and the dorsal motor nucleus of the vagus nerve after i.p. injection of ulcerogenic aspirin.
    Neuroscience letters, 1995, Feb-13, Volume: 185, Issue:3

    Topics: Animals; Aspirin; Ganglia, Spinal; Gene Expression; Immunohistochemistry; Male; Proto-Oncogene Prote

1995
Multiple esophageal ulcerations caused by a granular formulation of aspirin.
    Endoscopy, 1994, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Aspirin; Esophageal Diseases; Esophagitis; Esophagoscopy; Humans; Male; Ulcer

1994
Stenting in the carotid artery: initial experience in 110 patients.
    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery, 1996, Volume: 3, Issue:1

    Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Carotid Artery

1996
Ulcers of the rectal mucosa caused by suppositories containing acetylsalicylic acid.
    Journal of pediatric gastroenterology and nutrition, 1997, Volume: 25, Issue:4

    Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child, Preschoo

1997
Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.
    Gut, 1997, Volume: 41, Issue:3

    Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile

1997
Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer.
    Gastroenterology, 1998, Volume: 114, Issue:5

    Topics: Aspirin; Female; Humans; Intestinal Diseases; Male; Middle Aged; Peptic Ulcer; Postoperative Complic

1998
[Cecal ulcer associated with acetyl salicylic acid].
    Revista espanola de enfermedades digestivas, 1998, Volume: 90, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cecal Diseases; Female; Humans; Ulcer

1998
Unusual negative side effects of non-steroidal anti-inflammatory drugs in the proximal colon.
    Zeitschrift fur Gastroenterologie, 2000, Volume: 38, Issue:6

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Diseases; Diagnos

2000
[Drug-induced aphthae].
    Annales de dermatologie et de venereologie, 2001, Volume: 128, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Eruptions; Female; Genital Diseases, F

2001
[Effects of aspirin on pregnant women and fetus; tetracycline-induced esophageal ulcer; and re-evaluation of sulfa drugs, anti-inflammatory enzymes and vitamins].
    Nihon Shika Ishikai zasshi, 1977, Volume: 30, Issue:3

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anemia; Anti-Inflammatory Agents; Aspirin; Esophagea

1977
Aspirin and gastric ulcer.
    Mayo Clinic proceedings, 1975, Volume: 50, Issue:10

    Topics: Adult; Animals; Aspirin; Chronic Disease; Dose-Response Relationship, Drug; Female; Gastric Mucosa;

1975
Gastrointestinal effects and acute toxicity of suprofen.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Animals; Antidiarrheals; Aspirin; Digestive System; Dogs; Dose-Response Relationship, Drug; Drug Eva

1975
Ulcerations of the colon associated with naproxen and acetylsalicylic acid treatment.
    Gastrointestinal endoscopy, 1986, Volume: 32, Issue:3

    Topics: Aspirin; Back Pain; Colonic Diseases; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Midd

1986
Aspirin-induced esophageal hemorrhage.
    JAMA, 1988, Mar-18, Volume: 259, Issue:11

    Topics: Aspirin; Esophagitis; Humans; Male; Middle Aged; Ulcer

1988
Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
    Acta physiologica Hungarica, 1985, Volume: 65, Issue:3

    Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Eating; Female; Indomethacin; Intestinal Disease

1985
Mouth ulcers associated with prolonged chewing of gum containing aspirin.
    JAMA, 1967, Nov-13, Volume: 202, Issue:7

    Topics: Aspirin; Blood Glucose; Blood Urea Nitrogen; Chewing Gum; gamma-Globulins; Humans; L-Lactate Dehydro

1967
The acute rectal toxicity of acetylsalicylic acid.
    Canadian journal of physiology and pharmacology, 1966, Volume: 44, Issue:6

    Topics: Adrenal Glands; Animals; Aspirin; Ataxia; Body Weight; Brain; Coma; Diarrhea; Diuresis; Dyspnea; Fee

1966
Unusual causes of occult bleeding from the gastrointestinal tract.
    American journal of surgery, 1970, Volume: 119, Issue:2

    Topics: Adolescent; Adult; Aged; Anemia; Aspirin; Child; Diagnosis, Differential; Esophagitis, Peptic; Femal

1970
The development of an antirheumatic drug.
    Rheumatology and physical medicine, 1971, Volume: 11, Issue:2

    Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cats; Chloroquine;

1971