aspirin has been researched along with Tinnitus in 37 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Tinnitus: A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper explores the effect of aspirin on the tinnitus of one patient for whom two contralateral spontaneous otoacoustic emissions (SOAEs) caused binaural tinnitus." | 9.07 | Indications for aspirin as a palliative for tinnitus caused by SOAEs: a case study. ( Coles, RR; Penner, MJ, 1992) |
| "In a double-blind between-patient study of aspirin and benorylate carried out in 72 outpatients with rheumatoid arthritis, benorylate 4 g twice daily was shown to be an effective analgesic and anti-inflammatory drug, its effects being indistinguishable from those of aspirin 1." | 9.03 | Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis. ( Beales, DL; Burry, HC; Grahame, R, 1972) |
| "A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter." | 7.75 | Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. ( Koren, G, 2009) |
| " Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months." | 6.64 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974) |
| "The tinnitus was no longer described as monaural and "tonal" but instead was described as being "noise in the head." | 5.28 | Aspirin abolishes tinnitus caused by spontaneous otoacoustic emissions. A case study. ( Penner, MJ, 1989) |
| "This paper explores the effect of aspirin on the tinnitus of one patient for whom two contralateral spontaneous otoacoustic emissions (SOAEs) caused binaural tinnitus." | 5.07 | Indications for aspirin as a palliative for tinnitus caused by SOAEs: a case study. ( Coles, RR; Penner, MJ, 1992) |
| "Tinnitus or subjective hearing loss, or both, were reported by 61 of 134 (45%) patients with rheumatoid arthritis (RA) taking regular salicylates and by 73 of 182 (40%) untreated healthy subjects." | 5.06 | Salicylate ototoxicity in patients with rheumatoid arthritis: a controlled study. ( Halla, JT; Hardin, JG, 1988) |
| " Known side effects of aspirin-tinnitus, deafness, and gastrointestinal disturbance-were more efficiently shown and symptoms not included in the check list were more likely to be reported when a check list was not used." | 5.04 | Measurement of side effects of drugs. ( Huskisson, EC; Wojtulewski, JA, 1974) |
| "In a double-blind between-patient study of aspirin and benorylate carried out in 72 outpatients with rheumatoid arthritis, benorylate 4 g twice daily was shown to be an effective analgesic and anti-inflammatory drug, its effects being indistinguishable from those of aspirin 1." | 5.03 | Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis. ( Beales, DL; Burry, HC; Grahame, R, 1972) |
| "A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter." | 3.75 | Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. ( Koren, G, 2009) |
| "Add-Aspirin is a phase III, multi-centre, double-blind, placebo-controlled randomised trial with four parallel cohorts." | 2.82 | ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. ( Berkman, L; Cafferty, FH; Cameron, D; Coyle, C; Gilbert, D; Gupta, S; Kynaston, H; Langley, RE; MacKenzie, M; Pramesh, CS; Ring, A; Rowley, S; Wilson, RH, 2016) |
| " Almost half of the patients taking aspirin were unable to tolerate the drug in adequate dosage for six months." | 2.64 | Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin. ( Balme, HW; Berry, H; Hart, FD; Huskisson, EC; Scott, J; Wojtulewski, JA, 1974) |
| "The quinine-induced increase in hearing threshold and its recovery can be analysed according to 'the psychophysical power function'." | 2.55 | Concentration-Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms. ( Alvan, G; Berninger, E; Gustafsson, LL; Karlsson, KK; Paintaud, G; Wakelkamp, M, 2017) |
| " Among the documented adverse effects of aspirin is the potential for ototoxicity." | 2.38 | Ototoxicity associated with salicylates. A brief review. ( Brien, JA, 1993) |
| "The tinnitus was no longer described as monaural and "tonal" but instead was described as being "noise in the head." | 1.28 | Aspirin abolishes tinnitus caused by spontaneous otoacoustic emissions. A case study. ( Penner, MJ, 1989) |
| "A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 micrograms/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen." | 1.27 | Aspirin dosing using 15 grain enteric coated tablets. ( Feigal, D; Jang, H; Pollet, S; White, RH; Yim, CW, 1985) |
| " If preterm labour was stopped, the dosage had been reduced." | 1.26 | [Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)]. ( Berg, R; Bolte, A; Wolff, F, 1981) |
| " It returned to normal after withdrawal of acetylsalicylic acid in 3 cases, after decrease of the dosage in 2 cases and on the same dosage in 1 case." | 1.26 | [The value of serum salicylate determination in patients with rheumatoid arthritis (author's transl)]. ( Chen, HL; Han, SH; Lan, JL; Wang, WC; Wong, W; Wu, HS, 1980) |
| " dosing caused a small significant drop, especially at trough level." | 1.26 | Diflunisal, a new-acting analgesic and prostaglandin inhibitor: effect of concomitant acetylsalicylic acid therapy on ototoxicity and on disposition of both drugs. ( Ferber-Perret, F; Perrier, CV; Schulz, P; Steelman, SL; VandenHeuvel, WJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (64.86) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 5 (13.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen, P | 1 |
| Musisca, N | 1 |
| Binder, W | 1 |
| Alvan, G | 1 |
| Berninger, E | 1 |
| Gustafsson, LL | 1 |
| Karlsson, KK | 1 |
| Paintaud, G | 1 |
| Wakelkamp, M | 1 |
| Coyle, C | 1 |
| Cafferty, FH | 1 |
| Rowley, S | 1 |
| MacKenzie, M | 1 |
| Berkman, L | 1 |
| Gupta, S | 1 |
| Pramesh, CS | 1 |
| Gilbert, D | 1 |
| Kynaston, H | 1 |
| Cameron, D | 1 |
| Wilson, RH | 1 |
| Ring, A | 1 |
| Langley, RE | 1 |
| Allen, JR | 1 |
| Koren, G | 1 |
| Komaroff, AL | 1 |
| Leschziner, G | 1 |
| Connor, S | 1 |
| Wroe, SJ | 1 |
| Ferner, RE | 1 |
| MCCABE, PA | 1 |
| DEY, FL | 1 |
| MYERS, EN | 2 |
| BERNSTEIN, JM | 2 |
| FOSTIROPOLOUS, G | 1 |
| Wecker, H | 1 |
| Laubert, A | 1 |
| Zheng, Y | 1 |
| Baek, JH | 1 |
| Smith, PF | 1 |
| Darlington, CL | 1 |
| Tugwell, P | 1 |
| Hart, L | 1 |
| Kraag, G | 1 |
| Park, A | 1 |
| Dok, C | 1 |
| Bianchi, F | 1 |
| Goldsmith, C | 1 |
| Buchanan, WW | 1 |
| Wolff, F | 1 |
| Berg, R | 1 |
| Bolte, A | 1 |
| Lan, JL | 1 |
| Wong, W | 1 |
| Wang, WC | 1 |
| Wu, HS | 1 |
| Chen, HL | 1 |
| Han, SH | 1 |
| Brien, JA | 1 |
| Campbell, K | 1 |
| Schulz, P | 1 |
| Perrier, CV | 1 |
| Ferber-Perret, F | 1 |
| VandenHeuvel, WJ | 1 |
| Steelman, SL | 1 |
| Hazell, JW | 1 |
| Daneshmend, TK | 1 |
| Penner, MJ | 2 |
| Coles, RR | 1 |
| Putterman, C | 1 |
| Ben-Chetrit, E | 1 |
| Halla, JT | 1 |
| Hardin, JG | 1 |
| Grigor, RR | 1 |
| Spitz, PW | 1 |
| Furst, DE | 1 |
| Pollet, S | 1 |
| White, RH | 1 |
| Jang, H | 1 |
| Yim, CW | 1 |
| Feigal, D | 1 |
| Crifò, S | 1 |
| Di Feliciantonio, D | 1 |
| Di Francesco, G | 1 |
| Sidoli, A | 1 |
| Wright, R | 1 |
| Beales, DL | 1 |
| Burry, HC | 1 |
| Grahame, R | 1 |
| Wright, V | 1 |
| Haslock, I | 1 |
| Huskisson, EC | 2 |
| Wojtulewski, JA | 2 |
| Berry, H | 1 |
| Scott, J | 1 |
| Hart, FD | 1 |
| Balme, HW | 1 |
| Horton, EW | 1 |
| Jones, RL | 1 |
| Marr, CG | 1 |
| Mongan, E | 1 |
| Kelly, P | 1 |
| Nies, K | 1 |
| Porter, WW | 1 |
| Paulus, HE | 1 |
| Diem, E | 1 |
| Fritsch, P | 1 |
| Pomare, EW | 1 |
| Treadwell, BL | 1 |
| Edmar, D | 1 |
| Surapathana, LO | 1 |
| Futrakul, P | 1 |
| Campbell, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Cold Water Immersion (CWI) on Pain in People With Gouty Arthritis: A Community Based Randomized Controlled Trial[NCT04587544] | 76 participants (Actual) | Interventional | 2019-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aspirin and Tinnitus
| Article | Year |
|---|---|
Concentration-Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Aspirin; Dose-Response Relationship | 2017 |
Ototoxicity associated with salicylates. A brief review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Hearing Loss; Humans; Salicylates; Tinnitus | 1993 |
Tinnitus.
Topics: Aspirin; Carbamazepine; Ear Diseases; Electric Stimulation Therapy; Hearing Loss, Noise-Induced; Hum | 1979 |
9 trials available for aspirin and Tinnitus
| Article | Year |
|---|---|
ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Chemotherapy, Adjuvant; Colorect | 2016 |
Indications for aspirin as a palliative for tinnitus caused by SOAEs: a case study.
Topics: Aspirin; Ear Diseases; England; Female; Hospitals, General; Humans; Male; Palliative Care; Placebo E | 1992 |
Salicylate ototoxicity in patients with rheumatoid arthritis: a controlled study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Aspirin; Audiometry; Clinical Trials as Topic | 1988 |
Comparison of aspirin and benorylate in the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Analgesics; Aniline Compounds; Anti-Inflammatory Agents; Arthritis, Rheumat | 1972 |
Toxicity of benorylate.
Topics: Acetanilides; Acetates; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as | 1973 |
Treatment of rheumatoid arthritis with fenoprofen: comparison with aspirin.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Body Temperature; Clinical Trials as Topic; Deafness; | 1974 |
Measurement of side effects of drugs.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse React | 1974 |
Sustained release aspirin.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Deafness; Delayed-Action Preparations; Female; Human | 1971 |
Effects of salicylates on the gastric mucosa as revealed by roentgen examination and the gastrocamera.
Topics: Aspirin; Clinical Trials as Topic; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Heartbu | 1971 |
25 other studies available for aspirin and Tinnitus
| Article | Year |
|---|---|
A 57-year-old man with a spontaneous carotid artery dissection.
Topics: Aspirin; Carotid Artery, Internal, Dissection; Dyspnea; Fibrinolytic Agents; Humans; Male; Medical H | 2018 |
The woman who heard music: high salicylate levels and tinnitus.
Topics: Aged; Aspirin; Diagnosis, Differential; Female; Hallucinations; Humans; Music; Salicylates; Tinnitus | 2008 |
Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Progression; Female; Hearing Loss; | 2009 |
By the way, doctor. I am 85 and have taken an 81-mg aspirin each day for decades for heart attack prevention. Recently, I noticed these words on the label: "Stop using if you get ringing in your ears or loss of hearing." Should I be worried?
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Dru | 2010 |
An unusual case of hearing loss in a patient with neurofibromatosis type 1.
Topics: Age of Onset; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Audiometry, Pure-Tone; Cerebral Angi | 2012 |
THE EFFECT OF ASPIRIN UPON AUDITORY SENSITIVITY.
Topics: Aspirin; Audiometry; Cochlea; Deafness; Hearing Tests; Humans; Pharmacology; Tinnitus; Toxicology | 1965 |
SALICYLATE OTOTOXICITY: A CLINICAL STUDY.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Audiometry; Blood; Cochlea; Drug Therapy; Enzyme Inhibito | 1965 |
[Reversible hearing loss in acute salicylate intoxication].
Topics: Adaptation, Physiological; Adult; Aspirin; Drug Overdose; Hearing Loss; Humans; Male; Otoacoustic Em | 2004 |
Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus.
Topics: Animals; Aspirin; Auditory Pathways; Behavior, Animal; Cell Count; Cochlear Nucleus; Disease Models, | 2007 |
Controlled trial of clinical utility of serum salicylate monitoring in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Deafness; Double-Blind Method; Drug Administration Schedule; Evaluat | 1984 |
[Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)].
Topics: Aspirin; Female; Fenoterol; Headache; Humans; Hyperventilation; Obstetric Labor, Premature; Pregnanc | 1981 |
[The value of serum salicylate determination in patients with rheumatoid arthritis (author's transl)].
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Chemical and Drug Induced Liver Injury; Dose-Response Relatio | 1980 |
Tinnitus and vertigo.
Topics: Aspirin; Humans; Ibuprofen; Temporomandibular Joint Dysfunction Syndrome; Tinnitus; Vertigo | 1993 |
Diflunisal, a new-acting analgesic and prostaglandin inhibitor: effect of concomitant acetylsalicylic acid therapy on ototoxicity and on disposition of both drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Interactions; Hemostasis; Humans; Male | 1979 |
Treatment of tinnitus.
Topics: Aspirin; Drug Administration Schedule; Humans; Tinnitus | 1979 |
Tinnitus due to low-dose aural aspirin therapy.
Topics: Aspirin; Ear; Foreign Bodies; Humans; Male; Middle Aged; Tinnitus | 1990 |
Aspirin abolishes tinnitus caused by spontaneous otoacoustic emissions. A case study.
Topics: Aspirin; Cochlea; Female; Humans; Middle Aged; Perceptual Masking; Tinnitus | 1989 |
Salicylate toxicity in elderly patients with rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Arthritis, Rheumatoid; Aspirin; Central Nervous System Diseases; Dose-Resp | 1987 |
Aspirin dosing using 15 grain enteric coated tablets.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Gastrointestinal Diseases; Humans; Male; Middle | 1985 |
[Research on the chronic audio-toxicity of aspirin in the guinea pig].
Topics: Animals; Aspirin; Audiometry; Chronic Disease; Deafness; Ear; Guinea Pigs; Hearing; Labyrinth Diseas | 1974 |
Effects of aspirin on prostaglandin and fructose levels in human semen.
Topics: Adult; Aspirin; Deafness; Factor Analysis, Statistical; Fructose; Humans; Male; Nausea; Prostaglandi | 1973 |
Tinnitus as an indication of therapeutic serum salicylate levels.
Topics: Age Factors; Aged; Arthritis, Rheumatoid; Aspirin; Audiometry; Drug Tolerance; Humans; Indomethacin; | 1973 |
[Salicylate poisoning by percutaneous resorption].
Topics: Administration, Topical; Aspirin; Deafness; Epistaxis; Female; Hallucinations; Headache; Humans; Poi | 1973 |
Salicylate ototoxicity; a clinical and experimental study.
Topics: Adolescent; Adult; Aged; Animals; Arthritis, Rheumatoid; Aspirin; Audiometry; Cochlea; Deafness; Hap | 1965 |
Salicylism revisited. Unusual problems in diagnosis and management.
Topics: Acidosis, Respiratory; Adolescent; Adult; Alkalosis; Aspirin; Central Nervous System; Colic; Diuresi | 1970 |