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aspirin and Stevens-Johnson Syndrome

aspirin has been researched along with Stevens-Johnson Syndrome in 22 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
" This review will discuss allergic and immunologic reactions to immunomodulators, penicillins and cephalosporins, sulfonamides, aspirin, and nonselective nonsteroidal anti-inflammatory drugs and consider the serious drug-related conditions of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)."4.838. Drug allergy. ( Greenberger, PA, 2006)
"Observations of Lyell's syndrome in two girls, one 2 and the other 7 years of age, investigated serologically, histologically and by immunofluorescent technique, are reported."1.26Lyell's syndrome: histological, immunohistochemical and serological observations. ( Babala, J; Blazovsky, J; Brozman, M, 1976)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199017 (77.27)18.7374
1990's2 (9.09)18.2507
2000's3 (13.64)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jao, T1
Tsai, TH1
Jeng, JS1
NEGRO, RC1
GENTILE RAMOS, I1
VIGNALE, R1
BRUM BUTLER, JL1
Greenberger, PA1
Lowney, ED1
Baublis, JV1
Kreye, GM1
Harrell, ER1
McKenzie, AR1
Bianchine, JR1
Alexander, MS1
Andresen, BD1
Ng, KJ1
Dämmrich, J1
Ormanns, W1
Nagy, G1
Meszáros, A1
Mahé, A1
Kéita, S1
Blanc, L1
Bobin, P1
Kaufman, DW1
Kelly, JP1
Odinokova, VA1
Kriuchkova, GS1
Hunziker, N1
Babala, J1
Brozman, M1
Blazovsky, J1
Sfar, Z1
Belkahia, C1
Kamoun, M1
Bigby, M1
Stern, R1
Dahle, MG1
Spahr, A1
Rossier, J1
Délèze, G1
Monnat, A1
Bruinsma, W1
Nava Negrete, A1
Baker, H1
Ocheret'ko, MP1

Reviews

2 reviews available for aspirin and Stevens-Johnson Syndrome

ArticleYear
8. Drug allergy.
    The Journal of allergy and clinical immunology, 2006, Volume: 117, Issue:2 Suppl Mi

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Aspirin; Cephalosporins; Cytokines;

2006
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:5 Pt 1

    Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-

1985

Other Studies

20 other studies available for aspirin and Stevens-Johnson Syndrome

ArticleYear
Aggrenox (Asasantin retard)-induced Stevens-Johnson syndrome.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:2

    Topics: Aged; Aspirin; Aspirin, Dipyridamole Drug Combination; Dipyridamole; Drug Combinations; Female; Huma

2009
[Toxic epidermal necrolysis (Lyell's syndrome)].
    Archivos de pediatria del Uruguay, 1963, Volume: 34

    Topics: Aspirin; Azo Compounds; Drug Eruptions; Herpesviridae Infections; Humans; Penicillins; Stevens-Johns

1963
The scalded skin syndrome in small children.
    Archives of dermatology, 1967, Volume: 95, Issue:4

    Topics: Aspirin; Child, Preschool; Erythema Multiforme; Female; Humans; Infant; Infant, Newborn; Male; Penic

1967
The aspirin/Reye's syndrome link.
    Lancet (London, England), 1982, Dec-11, Volume: 2, Issue:8311

    Topics: Aspirin; Humans; Reye Syndrome; Stevens-Johnson Syndrome; Sulfonamides

1982
[Lyell's syndrome and necrotizing granulomatous arteritis as simultaneous drug-induced reactions. A case report].
    Der Pathologe, 1982, Volume: 3, Issue:6

    Topics: Adult; Aspirin; Barbiturates; Caffeine; Drug Combinations; Humans; Male; Phenacetin; Polyarteritis N

1982
[Acetylsalicylic acid intolerance in Lyell syndrome].
    Dermatologische Monatschrift, 1984, Volume: 170, Issue:5

    Topics: Aspirin; Drug Combinations; Drug Eruptions; Female; Humans; Middle Aged; Respiratory Tract Infection

1984
Esophageal necrosis in the Stevens-Johnson syndrome.
    Journal of the American Academy of Dermatology, 1993, Volume: 29, Issue:1

    Topics: Adult; Aspirin; Epithelium; Esophagus; Humans; Male; Mucous Membrane; Necrosis; Stevens-Johnson Synd

1993
Cutaneous reactions to analgesic-antipyretics and nonsteroidal anti-inflammatory drugs. Analysis of reports to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia.
    Dermatology (Basel, Switzerland), 1993, Volume: 186, Issue:3

    Topics: Adverse Drug Reaction Reporting Systems; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspiri

1993
Acetylsalicylic acid and other salicylates in relation to Stevens-Johnson syndrome and toxic epidermal necrolysis.
    British journal of clinical pharmacology, 2001, Volume: 51, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Humans; Multivariate Analysi

2001
[Drug-induced bullous dermatitis - Lyell's syndrome].
    Arkhiv patologii, 1979, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Aspirin; Drug Eruptions; Female; Humans; Male; Penicillins; Pulmonary Alveoli; Sk

1979
[Toxic epidermal necrolysis (Lyell's syndrome) (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1979, Feb-27, Volume: 68, Issue:9

    Topics: Aged; Aspirin; Female; Fever; Humans; Stevens-Johnson Syndrome; Terminology as Topic

1979
Lyell's syndrome: histological, immunohistochemical and serological observations.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1976, Volume: 17, Issue:1

    Topics: Anti-Bacterial Agents; Antibodies; Antibody Formation; Aspirin; Child; Child, Preschool; Female; Hum

1976
[Severe bullous forms of drug eruptions].
    La Tunisie medicale, 1989, Volume: 67, Issue:12

    Topics: Adrenal Cortex Hormones; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbocy

1989
[Toxic epidermal necrolysis. Clinical aspects and treatment illustrated by a case history].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1988, Aug-30, Volume: 108, Issue:24

    Topics: Adult; Aspirin; Humans; Male; Stevens-Johnson Syndrome

1988
[Two cases of Lyell's syndrome (toxic epidermal necrosis) in children].
    Revue medicale de la Suisse romande, 1972, Volume: 92, Issue:12

    Topics: Aspirin; Child; Drug Hypersensitivity; gamma-Globulins; Humans; Male; Penicillins; Prednisone; Steve

1972
[Comparative study of Lyell's and Stevens-Johnson syndromes: etiologic role of drugs].
    Schweizerische medizinische Wochenschrift, 1972, Dec-23, Volume: 102, Issue:51

    Topics: Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Codeine; Female; Humans; Hydant

1972
Adverse reaction profiles of drug eruptions.
    Dermatologica, 1972, Volume: 145, Issue:6

    Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er

1972
[Stevens-Johnson syndrome. Review of 10 cases].
    Alergia, 1971, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Aspirin; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn;

1971
Intermittent high dose oral methotrexate therapy in psoriasis.
    The British journal of dermatology, 1970, Volume: 82, Issue:1

    Topics: Adult; Aged; Aspirin; Ataxia; Colitis; Female; Hematologic Diseases; Humans; Male; Methotrexate; Mid

1970
[Case of toxic epidermal necrolysis in a 6-year-old child].
    Pediatriia, 1970, Volume: 49, Issue:7

    Topics: Aspirin; Child; Humans; Male; Stevens-Johnson Syndrome; Sulfamethazine; Tetracycline

1970