Page last updated: 2024-10-23

aspirin and Sicca Syndrome

aspirin has been researched along with Sicca Syndrome in 12 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
" Therefore, the goal of this paper was to create a physiologically based pharmacokinetic (PBPK) model to offer a reasonable starting point for required total AT-RvD1 dosage to be administered in future mice and humans thereby eliminating the need for excessive use of animals and humans in preclinical and clinical trials, respectively."5.56Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome. ( Baker, OJ; Yellepeddi, VK, 2020)
" The goal of this study was to determine whether systemic preventive treatment with Aspirin-triggered RvD1 (AT-RvD1) reduces inflammation and preserves secretory functioning in NOD/ShiLtJ SS-like mice."3.85AT-RvD1 Promotes Resolution of Inflammation in NOD/ShiLtJ mice. ( Baker, OJ; Easley, JT; Maruyama, CL; Trump, BG; Wang, CS, 2017)
"Primary biliary cirrhosis is a disease of the small bile ducts with altered immunologic responsiveness often associated with various collagen diseases."2.36Primary biliary cirrhosis as a collagen disease. ( Schaffner, F, 1979)
"Treatment with hydroxychloroquine might not be enough to lower the cardiovascular risk significantly in diabetes patients with Sjögren syndrome."1.72Sjögren syndrome is a hidden contributor of macrovascular and microvascular complications in patients with type 2 diabetes. ( Leong, PY; Su, YJ; Wang, YH; Wei, JC, 2022)
" Therefore, the goal of this paper was to create a physiologically based pharmacokinetic (PBPK) model to offer a reasonable starting point for required total AT-RvD1 dosage to be administered in future mice and humans thereby eliminating the need for excessive use of animals and humans in preclinical and clinical trials, respectively."1.56Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome. ( Baker, OJ; Yellepeddi, VK, 2020)
" Therefore, we investigated whether the more stable aspirin-triggered (AT) epimer, AT-RvD1, combined with reduced doses of DEX is effective in treating TNF-α-mediated disruption of polarized rat parotid gland (Par-C10) epithelial cell clusters."1.43AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. ( Baker, OJ; Easley, JT; Maruyama, CL; Wang, CS, 2016)
"A diagnosis of mixed connective tissue disease (Sharp-syndrome) was established."1.30[A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome]. ( Hartmann, F; Kranzhöfer, N; Lindemuth, R; Zuber, M, 1998)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's1 (8.33)18.2507
2000's0 (0.00)29.6817
2010's4 (33.33)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Su, YJ1
Leong, PY1
Wang, YH1
Wei, JC1
Dos Santos, HT1
Nam, K2
Gil, D1
Yellepeddi, V1
Baker, OJ5
Yellepeddi, VK1
Wang, CS3
Maruyama, CL3
Easley, JT2
Trump, BG2
Placais, L1
Carrat, F1
Carbillon, L1
Nicaise Roland, P1
Benbara, A1
Cacciatore, C1
Fain, O1
Mekinian, A1
Dean, S1
Barrow, MV1
Quick, DT1
Cunningham, RW1
McKendry, RJ1
Zuber, M1
Kranzhöfer, N1
Lindemuth, R1
Hartmann, F1
Schaffner, F1
Tiger, LH1
Gordon, MH1
Ehrlich, GE1
Shapiro, B1

Reviews

2 reviews available for aspirin and Sicca Syndrome

ArticleYear
Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren's syndrome.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Aspirin; Humans; Inflammation; Lipids; Salivary Glands; Sjogren's Syndrome

2022
Primary biliary cirrhosis as a collagen disease.
    Postgraduate medicine, 1979, Volume: 65, Issue:6

    Topics: Adrenal Cortex Hormones; Antibodies; Antigen-Antibody Complex; Aspirin; Collagen Diseases; Complemen

1979

Other Studies

10 other studies available for aspirin and Sicca Syndrome

ArticleYear
Sjögren syndrome is a hidden contributor of macrovascular and microvascular complications in patients with type 2 diabetes.
    International journal of rheumatic diseases, 2022, Volume: 25, Issue:10

    Topics: Aspirin; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hydroxychlo

2022
Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome.
    Clinical and experimental dental research, 2020, Volume: 6, Issue:2

    Topics: Administration, Intravenous; Animals; Aspirin; Clinical Trials as Topic; Computer Simulation; Diseas

2020
AT-RvD1 Promotes Resolution of Inflammation in NOD/ShiLtJ mice.
    Scientific reports, 2017, 03-31, Volume: 7

    Topics: Animals; Aspirin; Dexamethasone; Docosahexaenoic Acids; Epithelium; Female; Inflammation; Male; Mice

2017
Obstetrical morbidity related to anti-SSA antibodies: Data from a French monocentric retrospective study.
    Joint bone spine, 2019, Volume: 86, Issue:4

    Topics: Adult; Antibodies, Antinuclear; Antiphospholipid Syndrome; Aspirin; Databases, Factual; Female; Fran

2019
Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren's syndrome mouse model.
    Rheumatology (Oxford, England), 2019, 07-01, Volume: 58, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cytokines; Disease Models, Animal; Docosa

2019
AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium.
    Physiological reports, 2016, Volume: 4, Issue:19

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Combined Modality Therapy; Dexamethasone;

2016
Salicylate hypoprothrombinemia in rheumatoid arthritis with liver disease. Report of two cases.
    Archives of internal medicine, 1967, Volume: 120, Issue:5

    Topics: Arthritis, Rheumatoid; Aspirin; Female; Hemorrhagic Disorders; Humans; Hypoprothrombinemias; Liver D

1967
Treatment of Sjogren's syndrome with essential fatty acids, pyridoxine and vitamin C.
    Prostaglandins, leukotrienes, and medicine, 1982, Volume: 8, Issue:4

    Topics: Ascorbic Acid; Aspartate Aminotransferases; Aspirin; Fatty Acids, Essential; Female; Humans; Indomet

1982
[A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome].
    Medizinische Klinik (Munich, Germany : 1983), 1998, Jan-15, Volume: 93, Issue:1

    Topics: Adult; Antiphospholipid Syndrome; Aspirin; Azathioprine; Biopsy; Diagnosis, Differential; Drug Thera

1998
Liver enlargement demonstrated by scintigraphy in rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 3, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Gold Sodium Thiomalate; Hepatomegaly; Humans; L

1976