aspirin has been researched along with Reperfusion Injury in 51 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with cilostazol for 7 days before ischemia significantly suppressed the risk and severity of cerebral hemorrhage after injection of tissue-type plasminogen activator, although treatment with aspirin had no such protective effect compared with nontreated mice." | 7.78 | Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model. ( Kasahara, Y; Matsuyama, T; Nakagomi, T; Stern, D; Taguchi, A, 2012) |
| "Our findings show that the use of dipyridamole before testicular reperfusion has a potentially protective effect against long-term injury in testicular ischemia reperfusion injury." | 7.78 | Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. ( Karagüzel, E; Kazaz, İO; Kutlu, Ö; Mungan, S; Özgür, GK; Tok, DS; Yuluğ, E, 2012) |
| "To investigate the protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion rats." | 7.72 | [Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats]. ( Chen, CH; Qiu, LY; Yu, J; Zhou, Y, 2003) |
| "Platelet-related events being associated with the increment of infarct size at reperfusion in the presence of a residual stenosis, we tested in dogs whether intravenous aspirin (ASA) could limit infarct size." | 7.70 | Intravenous aspirin at reperfusion does not reduce infarct size in the dog with a residual critical stenosis. ( Laperrière, L; Latour, JG; Libersan, D; Merhi, Y; Quan, E; Uzan, A, 1999) |
| "We determined if the thromboxane A2 antagonist SQ 30,741 can reduce ultimate myocardial infarct size and reperfusion injury." | 7.67 | Effect of the thromboxane A2 receptor antagonist SQ 30,741 on ultimate myocardial infarct size, reperfusion injury and coronary flow reserve. ( Grover, GJ; Schumacher, WA, 1989) |
| " Here, we confirmed the protective effect and mechanism of XST combined with DAPT (XST+ASA+CLP) on cerebral ischemia/reperfusion injury, exploring their better pharmacological action for clinical patients." | 5.62 | Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway. ( Dong, DX; Meng, XB; Qu, MW; Sun, GB; Sun, XB; Zhao, LY; Zhu, T, 2021) |
| "Stroke is the second leading cause of death." | 5.39 | Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke. ( Ahn, JH; Cho, JH; Choi, JH; Her, S; Hwang, IK; Hyun, BH; Jun, JG; Kim, CK; Kim, IH; Kim, JS; Kim, YM; Kwon, SH; Kwon, YG; Lee, CH; Lee, JC; Lee, YL; Park, JH; Shin, BN; Suh, HW; Won, MH; Yan, BC; Yoo, KY, 2013) |
| "Coronary thrombosis was produced by insertion of a thrombogenic copper coil into the LAD of 40 anesthetized pigs." | 5.30 | Coronary thrombosis/thrombolysis in pigs: effects of heparin, ASA, and the thrombin inhibitor inogatran. ( Hatori, N; Mattsson, C; Nordlander, R; Rydén, L; Sjöquist, PO; Uriuda, Y; Wang, QD, 1998) |
| "Treatment with cilostazol for 7 days before ischemia significantly suppressed the risk and severity of cerebral hemorrhage after injection of tissue-type plasminogen activator, although treatment with aspirin had no such protective effect compared with nontreated mice." | 3.78 | Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model. ( Kasahara, Y; Matsuyama, T; Nakagomi, T; Stern, D; Taguchi, A, 2012) |
| "Our findings show that the use of dipyridamole before testicular reperfusion has a potentially protective effect against long-term injury in testicular ischemia reperfusion injury." | 3.78 | Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. ( Karagüzel, E; Kazaz, İO; Kutlu, Ö; Mungan, S; Özgür, GK; Tok, DS; Yuluğ, E, 2012) |
| "To investigate the protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion rats." | 3.72 | [Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats]. ( Chen, CH; Qiu, LY; Yu, J; Zhou, Y, 2003) |
| "Platelet-related events being associated with the increment of infarct size at reperfusion in the presence of a residual stenosis, we tested in dogs whether intravenous aspirin (ASA) could limit infarct size." | 3.70 | Intravenous aspirin at reperfusion does not reduce infarct size in the dog with a residual critical stenosis. ( Laperrière, L; Latour, JG; Libersan, D; Merhi, Y; Quan, E; Uzan, A, 1999) |
| "We determined if the thromboxane A2 antagonist SQ 30,741 can reduce ultimate myocardial infarct size and reperfusion injury." | 3.67 | Effect of the thromboxane A2 receptor antagonist SQ 30,741 on ultimate myocardial infarct size, reperfusion injury and coronary flow reserve. ( Grover, GJ; Schumacher, WA, 1989) |
| "With the use of thrombolytic therapy, reperfusion injury, and its consequences came to the fore." | 1.91 | Investigation of the protective effect of anzer propolis in cerebral ischemia-reperfusion injury. ( Bülbül, A; Demirel, HH; Görücü, F; Koç, Y; Köseoğlu Toksoy, C; Sarıtaş, ZK; Türk Börü, Ü; Zeytin Demiral, G, 2023) |
| " Here, we confirmed the protective effect and mechanism of XST combined with DAPT (XST+ASA+CLP) on cerebral ischemia/reperfusion injury, exploring their better pharmacological action for clinical patients." | 1.62 | Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway. ( Dong, DX; Meng, XB; Qu, MW; Sun, GB; Sun, XB; Zhao, LY; Zhu, T, 2021) |
| "Stroke is the second leading cause of death." | 1.39 | Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke. ( Ahn, JH; Cho, JH; Choi, JH; Her, S; Hwang, IK; Hyun, BH; Jun, JG; Kim, CK; Kim, IH; Kim, JS; Kim, YM; Kwon, SH; Kwon, YG; Lee, CH; Lee, JC; Lee, YL; Park, JH; Shin, BN; Suh, HW; Won, MH; Yan, BC; Yoo, KY, 2013) |
| "Lung injury was assessed by wet/dry ratio, myeloperoxidase (MPO) activity, and bronchoalveolar lavage (BAL) neutrophil counts." | 1.38 | Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect. ( Bouchier-Hayes, D; Condron, C; Cunningham, AJ; Gang, C; Scully, M, 2012) |
| " The present study investigated the importance of endogenous prostaglandin production and nitric oxide (NO) in the renal haemodynamic and excretory responses to ischaemia-reperfusion both normally and in the hypertensive state by chronic administration of cyclo-oxygenase (COX) inhibitors." | 1.35 | Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation. ( Johns, EJ; Knight, S, 2008) |
| "Triflusal is a fluorinated derivative of acetylsalicylic acid (ASA) with demonstrated antithrombotic activity." | 1.33 | Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids. ( Arrebola, MM; De La Cruz, JP; González-Correa, JA; Guerrero, A; Muñoz-Marín, J; Ruiz-Villafranca, D; Sánchez de la Cuesta, F; Ureña, IM, 2005) |
| "Aspirin that has been chemically combined with a nitric oxide (NO) donor (NCX-4016) has been shown to inhibit cyclooxygenase and prostaglandin generation while maintaining the inhibitory effects of aspirin." | 1.32 | Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheek pouch microcirculation. ( Bertuglia, S; Del Soldato, P; Giusti, A, 2004) |
| "Coronary thrombosis was produced by insertion of a thrombogenic copper coil into the LAD of 40 anesthetized pigs." | 1.30 | Coronary thrombosis/thrombolysis in pigs: effects of heparin, ASA, and the thrombin inhibitor inogatran. ( Hatori, N; Mattsson, C; Nordlander, R; Rydén, L; Sjöquist, PO; Uriuda, Y; Wang, QD, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.96) | 18.7374 |
| 1990's | 12 (23.53) | 18.2507 |
| 2000's | 16 (31.37) | 29.6817 |
| 2010's | 17 (33.33) | 24.3611 |
| 2020's | 5 (9.80) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, W | 4 |
| Bi, Y | 4 |
| Xue, P | 2 |
| Zhang, Y | 5 |
| Gao, X | 4 |
| Wang, Z | 2 |
| Li, M | 2 |
| Baudy-Floc'h, M | 1 |
| Ngerebara, N | 1 |
| Li, X | 2 |
| Gibson, KM | 2 |
| Bi, L | 4 |
| Itagaki, Y | 1 |
| Wu, J | 1 |
| Ling, J | 1 |
| Wang, X | 1 |
| Li, T | 1 |
| Liu, J | 1 |
| Lai, Y | 1 |
| Ji, H | 1 |
| Peng, S | 1 |
| Tian, J | 1 |
| Yan, X | 1 |
| Harris, J | 1 |
| Legalley, TD | 2 |
| Li, P | 1 |
| Hou, S | 1 |
| Bammert, C | 1 |
| Jockusch, S | 1 |
| Michael Gibson, K | 1 |
| Zhao, D | 1 |
| Chen, X | 1 |
| Wang, R | 1 |
| Pang, H | 1 |
| Wang, J | 1 |
| Liu, L | 1 |
| Köseoğlu Toksoy, C | 1 |
| Sarıtaş, ZK | 1 |
| Türk Börü, Ü | 1 |
| Zeytin Demiral, G | 1 |
| Görücü, F | 1 |
| Bülbül, A | 1 |
| Demirel, HH | 1 |
| Koç, Y | 1 |
| Sadek, G | 1 |
| Santillan, A | 1 |
| Gandy, C | 1 |
| Safi, N | 1 |
| Segal, AZ | 1 |
| Zhu, T | 1 |
| Meng, XB | 1 |
| Dong, DX | 1 |
| Zhao, LY | 1 |
| Qu, MW | 1 |
| Sun, GB | 1 |
| Sun, XB | 1 |
| Li, F | 1 |
| Xu, D | 1 |
| Hou, K | 1 |
| Gou, X | 1 |
| Lv, N | 1 |
| Fang, W | 1 |
| Li, Y | 1 |
| Zhang, T | 1 |
| Xiu, HH | 1 |
| Liu, JX | 1 |
| Ma, Y | 1 |
| Xu, KQ | 1 |
| Huang, WQ | 1 |
| Amagase, K | 1 |
| Yoshida, Y | 1 |
| Hara, D | 1 |
| Murakami, T | 1 |
| Takeuchi, K | 1 |
| Brancaleone, V | 1 |
| Gobbetti, T | 1 |
| Cenac, N | 1 |
| le Faouder, P | 1 |
| Colom, B | 1 |
| Flower, RJ | 1 |
| Vergnolle, N | 1 |
| Nourshargh, S | 1 |
| Perretti, M | 1 |
| Yan, BC | 1 |
| Park, JH | 2 |
| Shin, BN | 1 |
| Ahn, JH | 1 |
| Kim, IH | 1 |
| Lee, JC | 1 |
| Yoo, KY | 1 |
| Hwang, IK | 1 |
| Choi, JH | 1 |
| Lee, YL | 1 |
| Suh, HW | 1 |
| Jun, JG | 1 |
| Kwon, YG | 1 |
| Kim, YM | 1 |
| Kwon, SH | 1 |
| Her, S | 1 |
| Kim, JS | 1 |
| Hyun, BH | 1 |
| Kim, CK | 1 |
| Cho, JH | 1 |
| Lee, CH | 1 |
| Won, MH | 1 |
| Koşucu, M | 1 |
| Coşkun, I | 1 |
| Eroglu, A | 1 |
| Kutanis, D | 1 |
| Menteşe, A | 1 |
| Karahan, SC | 1 |
| Baki, E | 1 |
| Kerimoğlu, S | 1 |
| Topbas, M | 1 |
| Silber, T | 1 |
| Ziemann, U | 1 |
| Ernemann, U | 1 |
| Bischof, F | 1 |
| Demirtas, S | 1 |
| Karahan, O | 1 |
| Yazıcı, S | 1 |
| Guclu, O | 1 |
| Calıskan, A | 1 |
| Tezcan, O | 1 |
| Kaplan, I | 1 |
| Yavuz, C | 1 |
| Serhan, CN | 4 |
| Chiang, N | 3 |
| Dalli, J | 1 |
| Kiyokuni, M | 1 |
| Kosuge, M | 1 |
| Ebina, T | 1 |
| Hibi, K | 1 |
| Tsukahara, K | 1 |
| Okuda, J | 1 |
| Iwahashi, N | 1 |
| Maejima, N | 1 |
| Kusama, I | 1 |
| Komura, N | 1 |
| Nakayama, N | 1 |
| Umemura, S | 1 |
| Kimura, K | 1 |
| Scully, M | 1 |
| Gang, C | 1 |
| Condron, C | 1 |
| Bouchier-Hayes, D | 1 |
| Cunningham, AJ | 1 |
| Kasahara, Y | 1 |
| Nakagomi, T | 1 |
| Matsuyama, T | 1 |
| Stern, D | 1 |
| Taguchi, A | 1 |
| Barreto, AD | 1 |
| Alexandrov, AV | 1 |
| Karagüzel, E | 1 |
| Kutlu, Ö | 1 |
| Yuluğ, E | 1 |
| Mungan, S | 1 |
| Kazaz, İO | 1 |
| Tok, DS | 1 |
| Özgür, GK | 1 |
| Marcheselli, VL | 1 |
| Hong, S | 1 |
| Lukiw, WJ | 1 |
| Tian, XH | 1 |
| Gronert, K | 3 |
| Musto, A | 1 |
| Hardy, M | 1 |
| Gimenez, JM | 1 |
| Bazan, NG | 1 |
| Bertuglia, S | 1 |
| Giusti, A | 1 |
| Del Soldato, P | 2 |
| Qiu, LY | 1 |
| Yu, J | 1 |
| Zhou, Y | 1 |
| Chen, CH | 1 |
| Bannenberg, G | 1 |
| Moussignac, RL | 1 |
| Devchand, PR | 1 |
| Schmidt, BA | 1 |
| Guilford, WJ | 1 |
| Bauman, JG | 1 |
| Subramanyam, B | 1 |
| Perez, HD | 1 |
| Parkinson, JF | 1 |
| Emanueli, C | 1 |
| Van Linthout, S | 1 |
| Salis, MB | 1 |
| Monopoli, A | 1 |
| Ongini, E | 1 |
| Madeddu, P | 1 |
| Welsh, RC | 1 |
| Armstrong, PW | 1 |
| González-Correa, JA | 2 |
| Arrebola, MM | 2 |
| Ureña, IM | 1 |
| Ruiz-Villafranca, D | 1 |
| Muñoz-Marín, J | 2 |
| Guerrero, A | 2 |
| Sánchez de la Cuesta, F | 2 |
| De La Cruz, JP | 2 |
| Cleanthis, M | 1 |
| Smout, J | 1 |
| Bhattacharya, V | 1 |
| Ashour, H | 1 |
| Shenton, B | 1 |
| Stansby, G | 1 |
| Cansino, AL | 1 |
| Iba, T | 2 |
| Kidokoro, A | 1 |
| Fukunaga, M | 1 |
| Takuhiro, K | 1 |
| Ouchi, M | 1 |
| Ito, Y | 1 |
| Gresele, P | 1 |
| Migliacci, R | 1 |
| Procacci, A | 1 |
| De Monte, P | 1 |
| Bonizzoni, E | 1 |
| Nishizawa, T | 1 |
| Suzuki, H | 1 |
| Masaoka, T | 1 |
| Hibi, T | 1 |
| Knight, S | 1 |
| Johns, EJ | 1 |
| Kawabata, H | 1 |
| Sugiyama, K | 1 |
| Katori, R | 1 |
| Nolte, D | 2 |
| Botzlar, A | 1 |
| Pickelmann, S | 2 |
| Bouskela, E | 1 |
| Messmer, K | 2 |
| Brzozowski, T | 1 |
| Konturek, PC | 1 |
| Konturek, SJ | 1 |
| Pajdo, R | 1 |
| Bielanski, W | 1 |
| Brzozowska, I | 1 |
| Stachura, J | 1 |
| Hahn, EG | 1 |
| Matsuno, N | 1 |
| Muto, S | 1 |
| Uchiyama, M | 1 |
| Kozaki, K | 1 |
| Kageyama, T | 1 |
| Suzuki, T | 1 |
| Kozaki, M | 1 |
| Nagao, T | 1 |
| Leiderer, R | 1 |
| Schütze, E | 1 |
| Uriuda, Y | 1 |
| Wang, QD | 1 |
| Hatori, N | 1 |
| Nordlander, R | 1 |
| Sjöquist, PO | 1 |
| Mattsson, C | 1 |
| Rydén, L | 1 |
| Mohr, JP | 1 |
| Hartmann, A | 1 |
| Chong, ZZ | 1 |
| Feng, YP | 1 |
| Wakatsuki, A | 1 |
| Izumiya, C | 1 |
| Okatani, Y | 1 |
| Sagara, Y | 1 |
| Clish, CB | 1 |
| O'Brien, JA | 1 |
| Freeman, MW | 1 |
| Libersan, D | 1 |
| Quan, E | 1 |
| Merhi, Y | 1 |
| Uzan, A | 1 |
| Laperrière, L | 1 |
| Latour, JG | 1 |
| Lieberthal, W | 1 |
| Fuhro, R | 1 |
| Andry, C | 1 |
| Valeri, CR | 1 |
| Sarfeh, IJ | 1 |
| Tarnawski, A | 1 |
| Grover, GJ | 1 |
| Schumacher, WA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II, Randomized, Single-Blind, Controlled Clinical Trial to Evaluate the Efficacy and Safety of Hemolink[Tm] (o-Raffinose Cross-Linked Human Hemoglobin) in Subjects Undergoing Primary Coronary Artery Bypass Grafting Surgery[NCT00038454] | Phase 2/Phase 3 | 180 participants | Interventional | Suspended | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aspirin and Reperfusion Injury
| Article | Year |
|---|---|
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Docosahexaenoic Acids; Fat | 2015 |
Adjunctive and alternative approaches to current reperfusion therapy.
Topics: Aspirin; Electric Stimulation Therapy; Endovascular Procedures; Fibrinogen; Fibrinolytic Agents; Hep | 2012 |
A marriage of enhancement: fibrinolysis and conjunctive therapy.
Topics: Animals; Antithrombins; Aspirin; Blood Platelets; Cell Adhesion; Clinical Trials as Topic; Dose-Resp | 2004 |
[Pretreatment with cilostazol protects against the vascular endothelial damage after ischemia/reperfusion].
Topics: Animals; Aspirin; Cilostazol; Dipyridamole; Endothelial Cells; Ischemic Preconditioning; Mice; Phosp | 2008 |
2 trials available for aspirin and Reperfusion Injury
| Article | Year |
|---|---|
The effects of spinal, inhalation, and total intravenous anesthetic techniques on ischemia-reperfusion injury in arthroscopic knee surgery.
Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Spina | 2014 |
Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication.
Topics: Aged; Aspirin; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Exercise; Female; Humans | 2007 |
45 other studies available for aspirin and Reperfusion Injury
| Article | Year |
|---|---|
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Crystallography, X-Ray; Dose-Response | 2011 |
Novel TEMPO-PEG-RGDs conjugates remediate tissue damage induced by acute limb ischemia/reperfusion.
Topics: Animals; Cyclic N-Oxides; Free Radical Scavengers; Hindlimb; Histocytochemistry; Malondialdehyde; Mu | 2012 |
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.
Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Fr | 2012 |
Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Curcumin; Cytochromes c; Disease Models, Animal; Edema; Enzyme-Li | 2016 |
Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cyclic N-Oxides; Cytochrome | 2017 |
Determining the chemical profile of Caragana jubata (Pall.) Poir. by UPLC-QTOF-MS analysis and evaluating its anti-ischemic stroke effects.
Topics: Animals; Aspirin; Brain Ischemia; Caragana; Infarction, Middle Cerebral Artery; Ischemic Stroke; Pla | 2023 |
Investigation of the protective effect of anzer propolis in cerebral ischemia-reperfusion injury.
Topics: Animals; Aspirin; Female; Interleukin-6; Nerve Growth Factor; Propolis; Rats; Reperfusion Injury | 2023 |
Cilioretinal artery occlusion in a patient with hereditary spherocytosis post-splenectomy.
Topics: Arterial Occlusive Diseases; Aspirin; Ciliary Arteries; Humans; Male; Middle Aged; Platelet Aggregat | 2020 |
Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway.
Topics: Animals; Aspirin; Clopidogrel; Drugs, Chinese Herbal; Inflammation; Interleukin-6; Oxidative Stress; | 2021 |
Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke.
Topics: Animals; Aspirin; Brain Ischemia; Clopidogrel; Inflammasomes; Ischemic Stroke; Isoindoles; NF-kappa | 2021 |
Protective effect of aspirin-triggered resolvin D1 on hepatic ischemia/reperfusion injury in rats: The role of miR-146b.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; Asp | 2017 |
Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.
Topics: Animals; Aspirin; Azulenes; Benzoquinones; Clopidogrel; Gastric Mucosa; Gastrointestinal Hemorrhage; | 2013 |
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Blood Vessels; Cytoprotection; Lipoxins; Male; Mice; Mic | 2013 |
Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzopyrans; Butyrates; Disease Models, A | 2013 |
Analysis of periinterventional complications of intracranial angioplasty and stenting: a single center experience.
Topics: Aged; Angioplasty; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Diabetes Complication | 2014 |
Investigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injury.
Topics: Animals; Anticoagulants; Aryldialkylphosphatase; Aspirin; Cardiotonic Agents; Clopidogrel; Dipeptida | 2015 |
Effects of pretreatment with statins on infarct size in patients with acute myocardial infarction who receive fibrinolytic therapy.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Creatine Kinas | 2009 |
Protective role of cyclooxygenase (COX)-2 in experimental lung injury: evidence of a lipoxin A4-mediated effect.
Topics: Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Iloprost; L | 2012 |
Cilostazol reduces the risk of hemorrhagic infarction after administration of tissue-type plasminogen activator in a murine stroke model.
Topics: Animals; Aspirin; Brain; Cerebral Hemorrhage; Cerebral Infarction; Cilostazol; Immunohistochemistry; | 2012 |
Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Aspirin; Dipyridamole; Disease Models, Animal; Drug Administration Schedule; In | 2012 |
Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Cells, Cultured; Cerebral Arteries | 2003 |
Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheek pouch microcirculation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arterioles; Aspirin; Blood Pressure; | 2004 |
[Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats].
Topics: Animals; Aspirin; Brain Ischemia; Disease Models, Animal; Epoprostenol; Male; Malondialdehyde; Neuro | 2003 |
Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asp | 2004 |
Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.
Topics: Animals; Apoptosis; Aspirin; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Ma | 2004 |
Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.
Topics: Animals; Aspirin; Brain Chemistry; Dinoprostone; Glutathione; Hypoxia, Brain; In Vitro Techniques; L | 2005 |
Treadmill exercise in claudicants on aspirin results in improved antioxidant status but only minimal platelet activation.
Topics: Aged; Aged, 80 and over; Antioxidants; Aspirin; Case-Control Studies; Exercise Test; Female; Humans; | 2005 |
Effects of aspirin plus alpha-tocopherol on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus.
Topics: alpha-Tocopherol; Animals; Antioxidants; Aspirin; Brain Ischemia; Cells, Cultured; Diabetes Mellitus | 2006 |
Comparison of the protective effects of type III phosphodiesterase (PDE3) inhibitor (cilostazol) and acetylsalicylic acid on intestinal microcirculation after ischemia reperfusion injury in mice.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aspirin; Cilostazol; Cyclic Nucleotide Phosphodiestera | 2006 |
Education and imaging. Gastrointestinal: enhanced gastric mucosal blood flow in aspirin intoxication.
Topics: Adult; Aspirin; Cyclooxygenase Inhibitors; Female; Gastric Mucosa; Humans; Regional Blood Flow; Repe | 2007 |
Renal functional responses to ischaemia-reperfusion injury in normotensive and hypertensive rats following non-selective and selective cyclo-oxygenase inhibition with nitric oxide donation.
Topics: Animals; Aspirin; Blood Pressure; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2008 |
Effect of acetylsalicylic acid on metabolism and contractility in the ischemic reperfused heart.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Triphosphate; Animals; Aspirin; C-Reactive Protein; Coronary | 1996 |
Effects of diaspirin-cross-linked hemoglobin (DCLHb) on the microcirculation of striated skin muscle in the hamster: a study on safety and toxicity.
Topics: Animals; Aspirin; Blood Substitutes; Blood Volume; Cricetinae; Diffusion Chambers, Culture; Endothel | 1997 |
The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; DNA; Dose-Response Relatio | 1997 |
Beneficial effect of aspirin and protease inhibitor as graft conditioning using machine perfusion in warm ischemically injured kidneys.
Topics: Animals; Aspirin; Creatinine; Dogs; Graft Survival; Heart Arrest; Humans; Kidney; Kidney Transplanta | 1997 |
Attenuation of postischemic reperfusion injury in striated skin muscle by diaspirin-cross-linked Hb.
Topics: Animals; Arterioles; Aspirin; Blood Flow Velocity; Blood Pressure; Blood Substitutes; Cricetinae; En | 1998 |
Coronary thrombosis/thrombolysis in pigs: effects of heparin, ASA, and the thrombin inhibitor inogatran.
Topics: Animals; Antithrombins; Aspirin; Blood Flow Velocity; Coronary Thrombosis; Glycine; Hemodynamics; He | 1998 |
Treatment of acute ischemic stroke: where are we?
Topics: Animals; Aspirin; Brain Damage, Chronic; Brain Ischemia; Calcium Channel Blockers; Cerebral Hemorrha | 1999 |
Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Benzofurans; Brain; Ischemic Attack, Transient; Neur | 1997 |
Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female | 1999 |
Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion.
Topics: Animals; Arachidonate 5-Lipoxygenase; Aspirin; Cell Line; Cell Movement; Crosses, Genetic; Ear, Exte | 1999 |
Intravenous aspirin at reperfusion does not reduce infarct size in the dog with a residual critical stenosis.
Topics: 6-Ketoprostaglandin F1 alpha; Anesthesia; Animals; Aspirin; Blood Cell Count; Cell Movement; Coronar | 1999 |
Effects of hemoglobin-based oxygen-carrying solutions in anesthetized rats with acute ischemic renal failure.
Topics: Acute Kidney Injury; Animals; Aspirin; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Hemog | 2000 |
Increased susceptibility of the portal hypertensive gastric mucosa to damage.
Topics: Animals; Aspirin; Bile Acids and Salts; Disease Models, Animal; Ethanol; Gastric Mucosa; Hypertensio | 1991 |
Effect of the thromboxane A2 receptor antagonist SQ 30,741 on ultimate myocardial infarct size, reperfusion injury and coronary flow reserve.
Topics: Adenosine; Animals; Aspirin; Coronary Circulation; Dogs; Female; Male; Myocardial Infarction; Recept | 1989 |