Page last updated: 2024-10-23

aspirin and Pyrosis

aspirin has been researched along with Pyrosis in 19 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"One hundred nineteen adults with active definite or classical rheumatoid arthritis were studied in a multicenter double-blind crossover study of naproxen (500 mg/day) and aspirin (3."9.04Naproxen and aspirin in rheumatoid arthritis: a multicenter double-blind crossover comparison study. ( Alexander, S; Diamond, H; Kuzell, W; Lussier, A; Odone, D; Tompkins, R, 1975)
"One hundred nineteen adults with active definite or classical rheumatoid arthritis were studied in a multicenter double-blind crossover study of naproxen (500 mg/day) and aspirin (3."5.04Naproxen and aspirin in rheumatoid arthritis: a multicenter double-blind crossover comparison study. ( Alexander, S; Diamond, H; Kuzell, W; Lussier, A; Odone, D; Tompkins, R, 1975)
"The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer."3.78Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study. ( Agudo, A; Ahrens, W; Barzan, L; Benhamou, S; Bouchardy, C; Brennan, P; Canova, C; Castellsague, X; Conway, DI; Healy, CM; Kjaerheim, K; Lagiou, A; Lagiou, P; Macfarlane, GJ; Macfarlane, TV; Marron, M; McCartan, BE; McKinney, PA; Merletti, F; Plzak, J; Pohlabeln, H; Richiardi, L; Simonato, L; Slamova, A; Sloan, P; Talamini, R; Thakker, NS; Thomson, P; Znaor, A, 2012)
" Fifteen healthy Japanese volunteers are dosed for 7 days in a 5-way randomly crossover trial: placebo, aspirin 100 mg, rabeprazole 10 mg, and aspirin 100 mg plus rabeprazole 10 mg either once daily or 4 times per day."2.75Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole. ( Furuta, T; Hishida, A; Ikuma, M; Kodaira, C; Nishino, M; Sugimoto, M; Sugimura, H; Tanaka, T; Yamade, M, 2010)
"Aspirin is a commonly used over-the-counter (OTC) agent for the symptomatic treatment of acute pain, fever, or the common cold, but data regarding safety in this context are limited."2.53Gastrointestinal Safety of Aspirin for a High-Dose, Multiple-Day Treatment Regimen: A Meta-Analysis of Three Randomized Controlled Trials. ( Forder, S; Lanas, A; Voelker, M, 2016)
"Aspirin was associated with dyspepsia and/or heartburn (OR = 1."1.29Nonsteroidal antiinflammatory drugs and dyspepsia in the elderly. ( Evans, JM; Fleming, KC; Harmsen, WS; Melton, LJ; Talley, NJ; Zinsmeister, AR, 1995)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19909 (47.37)18.7374
1990's2 (10.53)18.2507
2000's3 (15.79)29.6817
2010's5 (26.32)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Forder, S1
Voelker, M1
Lanas, A1
Sugimoto, M1
Nishino, M1
Kodaira, C1
Yamade, M1
Ikuma, M1
Tanaka, T1
Sugimura, H1
Hishida, A1
Furuta, T1
Scholl, S1
Dellon, ES1
Shaheen, NJ1
Macfarlane, TV1
Macfarlane, GJ1
Thakker, NS1
Benhamou, S1
Bouchardy, C1
Ahrens, W1
Pohlabeln, H1
Lagiou, P1
Lagiou, A1
Castellsague, X1
Agudo, A1
Slamova, A1
Plzak, J1
Merletti, F1
Richiardi, L1
Talamini, R1
Barzan, L1
Kjaerheim, K1
Canova, C1
Simonato, L1
Conway, DI1
McKinney, PA1
Thomson, P1
Sloan, P1
Znaor, A1
Healy, CM1
McCartan, BE1
Marron, M1
Brennan, P1
Chitose, T1
Hokimoto, S1
Oshima, S1
Nakao, K1
Fujimoto, K1
Miyao, Y1
Shimomura, H1
Tsunoda, R1
Maruyama, H1
Hirose, T1
Yamamoto, K1
Mizobe, M1
Kaikita, K1
Nakamura, S1
Ogawa, H1
Laheij, RJ1
Van Rossum, LG1
Jansen, JB1
Verheugt, FW1
Füessl, HS1
Stiefelhagen, P1
Rubegni, M1
Sacchetti, G1
Bruni, G1
De Mauro, G1
Provvedi, D1
Talley, NJ1
Evans, JM1
Fleming, KC1
Harmsen, WS1
Zinsmeister, AR1
Melton, LJ1
Karlowicz, MG1
White, LE1
Diamond, H1
Alexander, S1
Kuzell, W1
Lussier, A1
Odone, D1
Tompkins, R1
Howden, CW1
Sabesin, SM1
Boyce, HW1
King, CE1
Mann, JA1
Ruoff, G1
Wall, E1
Ramirez-Mata, M1
Reyes, PA1
Alarcon-Segovia, D1
Garza, R1
Holmes, EL1
Hill, AG1
Edmar, D1

Reviews

2 reviews available for aspirin and Pyrosis

ArticleYear
Gastrointestinal Safety of Aspirin for a High-Dose, Multiple-Day Treatment Regimen: A Meta-Analysis of Three Randomized Controlled Trials.
    Drugs in R&D, 2016, Volume: 16, Issue:3

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Female; Gastrointestinal Diseas

2016
Review of flufenamic acid in rheumatoid arthritis.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diarrhea; Dyspep

1966

Trials

8 trials available for aspirin and Pyrosis

ArticleYear
Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Inflammatory Agents, Non-Steroid

2010
Proton-pump inhibitor therapy for acetylsalicylic acid associated upper gastrointestinal symptoms: a randomized placebo-controlled trial.
    Alimentary pharmacology & therapeutics, 2003, Jul-01, Volume: 18, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;

2003
A double-blind evaluation of oral indoprofen versus ASA in osteoarthritic patients: influence on haemostatic parameters and clinical effects.
    European journal of rheumatology and inflammation, 1981, Volume: 4, Issue:1

    Topics: Adult; Aged; Aspirin; Bleeding Time; Clinical Trials as Topic; Double-Blind Method; Female; Heartbur

1981
Naproxen and aspirin in rheumatoid arthritis: a multicenter double-blind crossover comparison study.
    Journal of clinical pharmacology, 1975, Volume: 15, Issue:4 Pt. 2

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Female; Heartbur

1975
Comparative evaluation of gastrointestinal intolerance produced by plain and tri-buffered aspirin tablets.
    The American journal of gastroenterology, 1988, Volume: 83, Issue:11

    Topics: Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Gases; Heartburn; Humans; Mal

1988
Experimental observations on flufenamic, mefenamic, and meclofenamic acids. IV. Toleration by normal human subjects.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Adult; Anti-Inflammatory Agents; Aspirin; Biphenyl Compounds; Blood Coagulation; Blood Urea Nitrogen

1966
Review of flufenamic acid in rheumatoid arthritis.
    Annals of physical medicine, 1966, Volume: Suppl

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diarrhea; Dyspep

1966
Effects of salicylates on the gastric mucosa as revealed by roentgen examination and the gastrocamera.
    Acta radiologica: diagnosis, 1971, Volume: 11, Issue:1

    Topics: Aspirin; Clinical Trials as Topic; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Heartbu

1971

Other Studies

10 other studies available for aspirin and Pyrosis

ArticleYear
Treatment of GERD and proton pump inhibitor use in the elderly: practical approaches and frequently asked questions.
    The American journal of gastroenterology, 2011, Volume: 106, Issue:3

    Topics: Adenocarcinoma; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Aspirin; Barrett Esop

2011
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:4

    Topics: Adult; Aspirin; Candidiasis; Carcinoma, Squamous Cell; Case-Control Studies; Disease Susceptibility;

2012
Clinical outcomes following coronary stenting in Japanese patients treated with and without proton pump inhibitor.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:1

    Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Asian People; Aspirin; Clopidogrel; Coronar

2012
[Heartburn without esophagitis. Symptoms more important than the finding?].
    MMW Fortschritte der Medizin, 2003, Sep-25, Volume: 145, Issue:39

    Topics: Androstadienes; Antacids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ul

2003
[Gastroenterology in family practice. Updates for your "stomach patient"].
    MMW Fortschritte der Medizin, 2006, Jun-01, Volume: 148, Issue:22

    Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Dyspepsia; Esophagitis, Peptic; Family Practice; Heartburn;

2006
Nonsteroidal antiinflammatory drugs and dyspepsia in the elderly.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:6

    Topics: Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dyspepsia; Female; Heartbu

1995
Severe intracranial hemorrhage in a term neonate associated with maternal acetylsalicylic acid ingestion.
    Clinical pediatrics, 1993, Volume: 32, Issue:12

    Topics: Alcohol Drinking; Aspirin; Cerebral Hemorrhage; Female; Heartburn; Humans; Infant, Newborn; Male; Ma

1993
Treatment of common minor ailments.
    British medical journal (Clinical research ed.), 1986, Dec-13, Volume: 293, Issue:6561

    Topics: Acetaminophen; Antacids; Antiemetics; Aspirin; Dyspepsia; Female; Heartburn; Histamine H1 Antagonist

1986
Esophageal motility in systemic lupus erythematosus.
    The American journal of digestive diseases, 1974, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Azathioprine; Chloroquine; Deglutition Disorders; Dilatation; Drug

1974
Gastrointestinal disturbances with aspirin.
    The Medical letter on drugs and therapeutics, 1965, Sep-10, Volume: 7, Issue:19

    Topics: Animals; Aspirin; Dogs; Gastrointestinal Hemorrhage; Heartburn; Humans; Tablets, Enteric-Coated

1965