aspirin has been researched along with Pulmonary Hypertension in 50 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C)." | 7.72 | [Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia]. ( Chen, SX; Fan, XF; Wang, LX; Wang, MS; Zeng, HH, 2003) |
| "To investigate aspirin efficacy in patients with primary pulmonary hypertension (PPH) after a course of prostaglandin E-1 (PE) treatment." | 7.70 | [The use of aspirin in patients with primary pulmonary hypertension]. ( Belenkov, IuN; Chazova, IE; Lazutkina, VK; Martyniuk, TV; Masenko, VP, 1998) |
| "Cardiovascular responses to the calcium antagonist nifedipine, alone and combined with low dose acetylsalicyclic acid (ASA), were evaluated in a piglet model of endotoxin-induced pulmonary hypertension." | 7.67 | The effect of nifedipine alone or combined with low dose acetylsalicyclic acid on endotoxin-induced pulmonary hypertension in the piglet. ( Huth, RG; Jüngst, BK; Schranz, D; Stopfkuchen, H, 1988) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 7.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "Treatment with Verapamil or aspirin reduced both chronic hypoxic pulmonary hypertension and the hypertrophy of the right ventricle." | 5.26 | Effects of verapamil and aspirin on experimental chronic hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. ( Kentera, D; Susić, D; Zdravković, M, 1979) |
| "Five previously suspected risk factors (valve surgery, prior protamine exposure, history of pulmonary hypertension, fish allergy, and vasectomy), aspirin ingestion within 7 days of surgery, and demographic information were recorded." | 5.10 | Effect of site of venous protamine administration, previously alleged risk factors, and preoperative use of aspirin on acute protamine-induced pulmonary vasoconstriction. ( Comunale, ME; Haering, JM; Lowenstein, E; Mashikian, JS; Maslow, A; Robertson, LK, 2003) |
| "SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C)." | 3.72 | [Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia]. ( Chen, SX; Fan, XF; Wang, LX; Wang, MS; Zeng, HH, 2003) |
| "To investigate aspirin efficacy in patients with primary pulmonary hypertension (PPH) after a course of prostaglandin E-1 (PE) treatment." | 3.70 | [The use of aspirin in patients with primary pulmonary hypertension]. ( Belenkov, IuN; Chazova, IE; Lazutkina, VK; Martyniuk, TV; Masenko, VP, 1998) |
| "Cardiovascular responses to the calcium antagonist nifedipine, alone and combined with low dose acetylsalicyclic acid (ASA), were evaluated in a piglet model of endotoxin-induced pulmonary hypertension." | 3.67 | The effect of nifedipine alone or combined with low dose acetylsalicyclic acid on endotoxin-induced pulmonary hypertension in the piglet. ( Huth, RG; Jüngst, BK; Schranz, D; Stopfkuchen, H, 1988) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 3.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "Hemoptysis was significantly more likely to occur in patients receiving acetylsalicylic acid (P=." | 1.43 | Bleeding Complications After Endoscopic Lung Volume Reduction Coil Treatment: A Retrospective Observational Study. ( Harbaum, L; Ittrich, H; Klose, H; Kluge, S; Oqueka, T; Simon, M, 2016) |
| "Aspirin treatment also reduced right ventricular hypertrophy and pulmonary arteriole proliferation in ASA-treated PAH model." | 1.37 | Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. ( He, B; Pu, J; Shen, J; Shen, L, 2011) |
| "After the induction of fat embolism, intravenous aspirin was administered at a dose of 150 mg/hr for 2 hrs (aspirin-treated group)." | 1.30 | Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs. ( Gullichsen, E; Kuttila, K; Mucha, I; Nelimarkka, O; Niinikoski, J; Rautanen, M; Riutta, A, 1997) |
| "We conclude that, in experimental pulmonary embolism, structurally different cyclooxygenase inhibitors aggravate pulmonary hypertension and deteriorate gas exchange by an altered distribution of VA/Q essentially to lung units with a higher than normal VA/Q." | 1.28 | Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. ( Delcroix, M; Leeman, M; Lejeune, P; Melot, C; Naeije, R, 1992) |
| "Pretreatment with aspirin (10 mg/kg) protected sheep against the pulmonary vascular response and completely blocked thromboxane synthesis." | 1.27 | Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. ( Ali, M; Cooper, JD; McDonald, JW; Morgan, E; Townsend, ER, 1983) |
| "Pretreatment with aspirin (10 mg/kg) protected the sheep against the pulmonary vascular response to 20 micrograms of PAF and blocked completely the thromboxane synthesis." | 1.27 | Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep. ( McDonald, JW; Smallbone, BW; Taylor, NE, 1987) |
| "Isosorbide dinitrate was the only drug that elicited any reduction in pulmonary artery pressure; pulmonary vascular resistance decreased modestly." | 1.26 | Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. ( Bambach, D; Fontana, ME; Hermiller, JB; Huss, P; Leier, CV; Magorien, RD; Thompson, MJ; Unverferth, DV, 1982) |
| "Treatment with Verapamil or aspirin reduced both chronic hypoxic pulmonary hypertension and the hypertrophy of the right ventricle." | 1.26 | Effects of verapamil and aspirin on experimental chronic hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. ( Kentera, D; Susić, D; Zdravković, M, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (32.00) | 18.7374 |
| 1990's | 9 (18.00) | 18.2507 |
| 2000's | 9 (18.00) | 29.6817 |
| 2010's | 14 (28.00) | 24.3611 |
| 2020's | 2 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shao, B | 1 |
| Hoover, C | 1 |
| Shi, H | 1 |
| Kondo, Y | 1 |
| Lee, RH | 1 |
| Chen, J | 1 |
| Shan, X | 1 |
| Song, J | 1 |
| McDaniel, JM | 1 |
| Zhou, M | 1 |
| McGee, S | 1 |
| Vanhoorelbeke, K | 1 |
| Bergmeier, W | 1 |
| López, JA | 1 |
| George, JN | 1 |
| Xia, L | 1 |
| Huang, N | 1 |
| Zhu, TT | 1 |
| Liu, T | 1 |
| Ge, XY | 1 |
| Wang, D | 1 |
| Liu, H | 2 |
| Zhu, GX | 1 |
| Zhang, Z | 1 |
| Hu, CP | 1 |
| Zhou, C | 1 |
| Guo, X | 1 |
| Cui, Q | 1 |
| Liu, X | 1 |
| Su, G | 1 |
| Zhang, J | 1 |
| Nour, SM | 1 |
| Nour, HA | 1 |
| Mehta, JB | 1 |
| Roy, TM | 1 |
| Byrd, RP | 1 |
| Lopez, JI | 1 |
| Holdridge, A | 1 |
| Mendizabal, JE | 1 |
| Matura, LA | 1 |
| Ventetuolo, CE | 1 |
| Palevsky, HI | 2 |
| Lederer, DJ | 3 |
| Horn, EM | 3 |
| Mathai, SC | 1 |
| Pinder, D | 1 |
| Archer-Chicko, C | 1 |
| Bagiella, E | 3 |
| Roberts, KE | 3 |
| Tracy, RP | 2 |
| Hassoun, PM | 2 |
| Girgis, RE | 2 |
| Kawut, SM | 4 |
| Zalawadiya, SK | 1 |
| Lindenfeld, J | 1 |
| DiSalvo, T | 1 |
| Hiram, R | 1 |
| Rizcallah, E | 1 |
| Marouan, S | 1 |
| Sirois, C | 1 |
| Sirois, M | 1 |
| Morin, C | 1 |
| Fortin, S | 1 |
| Rousseau, E | 1 |
| Hansmann, G | 1 |
| Apitz, C | 1 |
| Simon, M | 1 |
| Ittrich, H | 1 |
| Harbaum, L | 1 |
| Oqueka, T | 1 |
| Kluge, S | 1 |
| Klose, H | 1 |
| Godfrey, A | 1 |
| Cajigas, HR | 1 |
| Gao, H | 1 |
| Cheng, Y | 1 |
| Zong, L | 1 |
| Huang, L | 1 |
| Qiao, C | 1 |
| Li, W | 1 |
| Gong, B | 1 |
| Hu, J | 1 |
| Wang, X | 1 |
| Zhao, C | 1 |
| Lammey, ML | 1 |
| Doane, CJ | 1 |
| Gigliotti, A | 1 |
| Lee, DR | 1 |
| Sleeper, MM | 1 |
| Shimbo, D | 2 |
| Al-Naamani, N | 1 |
| Barr, RG | 2 |
| Post, W | 2 |
| Tracy, R | 1 |
| Hassoun, P | 1 |
| Girgis, R | 1 |
| Zeng, HH | 1 |
| Wang, LX | 1 |
| Chen, SX | 1 |
| Wang, MS | 1 |
| Fan, XF | 1 |
| Shen, L | 1 |
| Shen, J | 1 |
| Pu, J | 1 |
| He, B | 1 |
| Hill, NS | 1 |
| Rosenzweig, EB | 1 |
| Rich, S | 1 |
| Comunale, ME | 1 |
| Maslow, A | 1 |
| Robertson, LK | 1 |
| Haering, JM | 1 |
| Mashikian, JS | 1 |
| Lowenstein, E | 1 |
| YUAN, SH | 1 |
| DOYLE, EF | 1 |
| PISACANO, JC | 1 |
| REED, GE | 1 |
| Weissmann, N | 1 |
| Manz, D | 1 |
| Buchspies, D | 1 |
| Keller, S | 1 |
| Mehling, T | 1 |
| Voswinckel, R | 1 |
| Quanz, K | 1 |
| Ghofrani, HA | 1 |
| Schermuly, RT | 1 |
| Fink, L | 1 |
| Seeger, W | 2 |
| Gassmann, M | 1 |
| Grimminger, F | 2 |
| Piomelli, S | 1 |
| Robbins, IM | 1 |
| Yung, D | 1 |
| Reilly, MP | 1 |
| Lloyd, W | 1 |
| Cunningham, G | 1 |
| Loscalzo, J | 1 |
| Kimmel, SE | 1 |
| Christman, BW | 1 |
| Barst, RJ | 1 |
| van Albada, ME | 1 |
| Berger, RM | 1 |
| Niggebrugge, M | 1 |
| van Veghel, R | 1 |
| Cromme-Dijkhuis, AH | 1 |
| Schoemaker, RG | 1 |
| Smedema, JP | 1 |
| Abrahams, S | 1 |
| Louw, VJ | 1 |
| McDonald, JW | 2 |
| Ali, M | 1 |
| Morgan, E | 1 |
| Townsend, ER | 1 |
| Cooper, JD | 1 |
| Niebyl, JR | 1 |
| Hermiller, JB | 1 |
| Bambach, D | 1 |
| Thompson, MJ | 1 |
| Huss, P | 1 |
| Fontana, ME | 1 |
| Magorien, RD | 1 |
| Unverferth, DV | 1 |
| Leier, CV | 1 |
| Rudolph, AM | 1 |
| Asherson, RA | 1 |
| Cervera, R | 1 |
| de Figueiredo, LF | 1 |
| Mathru, M | 1 |
| Solanki, D | 1 |
| Macdonald, VW | 1 |
| Hess, J | 1 |
| Kramer, GC | 1 |
| Rautanen, M | 1 |
| Gullichsen, E | 1 |
| Riutta, A | 1 |
| Kuttila, K | 1 |
| Mucha, I | 1 |
| Nelimarkka, O | 1 |
| Niinikoski, J | 1 |
| Sogawa, M | 1 |
| Mohammad, SF | 1 |
| Chazova, IE | 1 |
| Martyniuk, TV | 1 |
| Masenko, VP | 1 |
| Lazutkina, VK | 1 |
| Belenkov, IuN | 1 |
| Pulerwitz, TC | 1 |
| Waxman, S | 1 |
| Rowe, KA | 1 |
| Quist, WC | 1 |
| Lipinska, I | 1 |
| Verrier, RL | 1 |
| Kentera, D | 1 |
| Susić, D | 1 |
| Zdravković, M | 1 |
| Gillett, DG | 1 |
| Ford, GT | 1 |
| Hays, FL | 1 |
| Bianca, W | 1 |
| Delcroix, M | 1 |
| Melot, C | 1 |
| Lejeune, P | 1 |
| Leeman, M | 1 |
| Naeije, R | 1 |
| Obernitz, R | 1 |
| Thomas, M | 1 |
| Walmrath, D | 1 |
| Suttorn, N | 1 |
| Holland, IB | 1 |
| Eberspächer, B | 1 |
| Hugo, F | 1 |
| Bhakdi, S | 1 |
| Rostagno, C | 2 |
| Prisco, D | 1 |
| Abbate, R | 1 |
| Poggesi, L | 1 |
| Gensini, GF | 1 |
| Boncinelli, S | 1 |
| Marsili, M | 1 |
| Castellani, S | 1 |
| Lorenzi, P | 1 |
| Merciai, V | 1 |
| Linden, M | 1 |
| Chelucci, GL | 1 |
| Cresci, F | 1 |
| Smallbone, BW | 1 |
| Taylor, NE | 1 |
| Schranz, D | 1 |
| Huth, RG | 1 |
| Stopfkuchen, H | 1 |
| Jüngst, BK | 1 |
| Hainaut, P | 1 |
| Lavenne, E | 1 |
| Magy, JM | 1 |
| Lebacq, EG | 1 |
| Reeves, JT | 4 |
| Grover, RF | 1 |
| Daoud, FS | 3 |
| Estridge, M | 3 |
| Stone, WH | 1 |
| McGARY, D | 1 |
| Rådegran, K | 1 |
| Bergentz, SE | 1 |
| Lewis, DH | 1 |
| Ljungqvist, U | 1 |
| Olsson, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Multicenter Clinical Study of Aspirin for Prophylaxis in Patients With Hereditary or Acquired Thrombotic Thrombocytopenic Purpura[NCT05568147] | Phase 2/Phase 3 | 100 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | ||
| A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension[NCT00384865] | Phase 2 | 64 participants (Actual) | Interventional | 2006-09-30 | Terminated | ||
| Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728] | Phase 3 | 19 participants (Actual) | Interventional | 2013-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Please refer to the Adverse Event Tables for specific information (NCT00384865)
Timeframe: Measured at 6 months
| Intervention | events (Number) |
|---|---|
| Aspirin 81 mg | 59 |
| Aspirin Placebo | 66 |
| Simvastatin 40 mg | 66 |
| Simvastatin Placebo | 58 |
(NCT00384865)
Timeframe: Measured at 6 months
| Intervention | meters (Least Squares Mean) |
|---|---|
| Aspirin 81 mg | 438.0 |
| Aspirin Placebo | 438.5 |
| Simvastatin 40 mg | 425.0 |
| Simvastatin Placebo | 452.7 |
Defined by the addition of new PAH therapies or dose increases in previously stable PAH therapy, hospitalization for right-sided heart failure, lung transplantation, atrial septostomy, and cardiovascular and all-cause death. (NCT00384865)
Timeframe: Measured at 6 months
| Intervention | events (Number) |
|---|---|
| Aspirin 81 mg | 2 |
| Aspirin Placebo | 6 |
| Simvastatin 40 mg | 4 |
| Simvastatin Placebo | 4 |
4 reviews available for aspirin and Pulmonary Hypertension
| Article | Year |
|---|---|
Altitude headache.
Topics: Acute Disease; Adaptation, Physiological; Altitude; Altitude Sickness; Anti-Inflammatory Agents; Asp | 2013 |
Preterm parturition. Prostaglandin synthetase inhibitors.
Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P | 1981 |
Cardiac manifestations of the antiphospholipid syndrome.
Topics: Antibodies, Anticardiolipin; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Coronary Disease; H | 1993 |
Drug-induced lung disease.
Topics: Alveolitis, Extrinsic Allergic; Antineoplastic Agents; Aspirin; Bronchial Spasm; Eosinophilia; Human | 1978 |
5 trials available for aspirin and Pulmonary Hypertension
| Article | Year |
|---|---|
Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension.
Topics: Administration, Oral; Aspirin; Biomarkers; Chronic Disease; Dose-Response Relationship, Drug; Double | 2015 |
Rationale and design of a phase II clinical trial of aspirin and simvastatin for the treatment of pulmonary arterial hypertension: ASA-STAT.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Data Interpretatio | 2011 |
Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT.
Topics: Adult; Aspirin; Cholesterol; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; | 2011 |
Effect of site of venous protamine administration, previously alleged risk factors, and preoperative use of aspirin on acute protamine-induced pulmonary vasoconstriction.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aspirin; Cardiopulmonary Bypass; Constriction, Pathol | 2003 |
A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension.
Topics: Adult; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension, | 2006 |
41 other studies available for aspirin and Pulmonary Hypertension
| Article | Year |
|---|---|
Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP.
Topics: Aspirin; Blood Platelets; Humans; Hypertension, Pulmonary; Lectins, C-Type; Platelet Activation; Pla | 2022 |
Aspirin ameliorates pulmonary vascular remodeling in pulmonary hypertension by dampening endothelial-to-mesenchymal transition.
Topics: Animals; Aspirin; Endothelium; Epithelial-Mesenchymal Transition; Hypertension, Pulmonary; Rats; Sma | 2021 |
Sildenafil improves the function of endothelial cells in patients suffering from congenital heart disease with pulmonary hypertension.
Topics: Adiponectin; Animals; Aspirin; Endothelial Cells; Endothelin-1; Enzyme-Linked Immunosorbent Assay; H | 2016 |
Hemoptysis and respiratory failure following sildenafil use for pulmonary hypertension.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Therapy, Combination; Hemo | 2013 |
Rapid diagnosis of cardiac tamponade using pulsatility index variability in a patient with a HeartWare ventricular assist device.
Topics: Anticoagulants; Aspirin; Cardiac Tamponade; Diastole; Heart Failure; Heart-Assist Devices; Humans; H | 2015 |
Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium; Cell Movement; Docosahexaenoic Acids; Eic | 2015 |
Treatment of children with pulmonary hypertension. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK.
Topics: Adolescent; Anticoagulants; Aspirin; Calcium Channel Blockers; Child; Consensus; Contraceptives, Ora | 2016 |
Bleeding Complications After Endoscopic Lung Volume Reduction Coil Treatment: A Retrospective Observational Study.
Topics: Aged; Aspirin; Bronchial Arteries; Bronchoscopy; Embolization, Therapeutic; Emphysema; Female; Fluor | 2016 |
A 55-Year-Old Woman With Pulmonary Hypertension, Worsening Dyspnea, and Chest Pain.
Topics: Angina Pectoris; Aspirin; Clopidogrel; Compartment Syndromes; Coronary Vessels; Diagnosis, Different | 2014 |
Aspirin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing the ERK/MAPK pathway.
Topics: Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Flavonoids; Hypertension, Pulmonary; Hy | 2017 |
Diagnosis and treatment of pulmonary arterial hypertension and atrial fibrillation in an adult chimpanzee (Pan troglodytes).
Topics: Animals; Antihypertensive Agents; Aspirin; Atrial Fibrillation; Cardiotonic Agents; Digoxin; Diureti | 2008 |
[Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Carotid Arteries; Epoprostenol; Hypercapnia; Hyperte | 2003 |
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels.
Topics: Animals; Aspirin; Blood Pressure; Body Weight; Disease Models, Animal; Heart Rate; Hemodynamics; Hyp | 2011 |
Future of clinical trials for pulmonary hypertension.
Topics: Aspirin; Drug Therapy, Combination; Exercise Tolerance; Humans; Hypertension, Pulmonary; Randomized | 2011 |
SEVERE RHEUMATIC MITRAL INSUFFICIENCY IN CHILDHOOD AMENABLE TO SURGERY.
Topics: Aspirin; Blood Circulation; Cardiac Surgical Procedures; Child; Digitalis Glycosides; Electrocardiog | 1964 |
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Pressure | 2005 |
The splenectomy controversy.
Topics: Anticoagulants; Aspirin; Gaucher Disease; Humans; Hypertension, Pulmonary; Postoperative Complicatio | 2005 |
Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Pressure; Capillaries; Disease Models, Animal; Echocardiog | 2006 |
Partial reversal of hemolysis-associated pulmonary arterial hypertension in response to oral administration of L-arginine in a patient with hereditary spherocytosis.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arginine; Aspirin; He | 2007 |
Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Complement Activation; Female; Hype | 1983 |
Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension.
Topics: Adolescent; Adult; Aspirin; Diazoxide; Dipyridamole; Female; Hemodynamics; Humans; Hydralazine; Hype | 1982 |
Effects of aspirin and acetaminophen in pregnancy and in the newborn.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Aspirin; Blood Platelets; Female; Fetus; Humans | 1981 |
Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes.
Topics: Albumins; Animals; Aspirin; Cerebrovascular Circulation; Constriction, Pathologic; Disease Models, A | 1997 |
Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Embolism, Fat; Epoprosten | 1997 |
Involvement of fibrinogen in protamine-induced pulmonary hypertension.
Topics: Animals; Aspirin; Blood; Blood Pressure; Cattle; Cyclooxygenase Inhibitors; Disease Models, Animal; | 1997 |
[The use of aspirin in patients with primary pulmonary hypertension].
Topics: Adult; Alprostadil; Aspirin; Calcium Channel Blockers; Drug Evaluation; Drug Therapy, Combination; F | 1998 |
Transatrial access to the normal pericardial space for local cardiac therapy: preclinical safety testing with aspirin and pulmonary artery hypertension.
Topics: Animals; Aspirin; Disease Models, Animal; Heart Atria; Hypertension, Pulmonary; Pericardium; Pulmona | 2001 |
Effects of verapamil and aspirin on experimental chronic hypoxic pulmonary hypertension and right ventricular hypertrophy in rats.
Topics: Animals; Aspirin; Biological Transport; Calcium; Cardiomegaly; Chronic Disease; Female; Haplorhini; | 1979 |
Pulmonary hypertention, blood coagulation and aspirin treatment in high altitude exposed cattle.
Topics: Altitude; Animals; Aspirin; Blood Coagulation; Castration; Cattle; Hypertension, Pulmonary; Male; Pr | 1976 |
Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dogs; Hypertension, Pulmonary; Indomethacin; Pulmonary | 1992 |
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Pressure; Capillary Permeability; Epoprostenol | 1991 |
Pulmonary hypertension associated with long-standing thrombocytosis.
Topics: Adult; Aspirin; beta-Thromboglobulin; Fibrinopeptide A; Heparin; Humans; Hypertension, Pulmonary; Ma | 1991 |
The prominent role of thromboxane A2 formation on early pulmonary hypertension induced by oleic acid administration in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Blood Pressure; Disease Models, Ani | 1990 |
Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep.
Topics: Animals; Aspirin; Complement Activation; Complement System Proteins; Dose-Response Relationship, Dru | 1987 |
The effect of nifedipine alone or combined with low dose acetylsalicyclic acid on endotoxin-induced pulmonary hypertension in the piglet.
Topics: Animals; Animals, Newborn; Aspirin; Disease Models, Animal; Drug Combinations; Drug Evaluation, Prec | 1988 |
Circulating lupus type anticoagulant and pulmonary hypertension associated with mixed connective tissue disease.
Topics: Adult; Arterial Occlusive Diseases; Aspirin; Blood Coagulation Factors; Dipyridamole; Female; Hand; | 1986 |
Blockade of acute hypoxic pulmonary hypertension by endotoxin.
Topics: Animals; Aspirin; Blood Pressure; Cardiac Output; Dogs; Endotoxins; Escherichia coli; Hypertension, | 1974 |
Pulmonary hypertension caused by minute amounts of endotoxin in calves.
Topics: Animals; Aspirin; Blood Pressure; Cattle; Chlorpheniramine; Endotoxins; Histamine; Hypertension, Pul | 1972 |
Endotoxin: a cause of spontaneous pulmonary hypertension in cattle?
Topics: Animals; Animals, Newborn; Aorta; Aspirin; Blood Pressure; Cardiac Catheterization; Cardiac Output; | 1973 |
Pulmonary pressor effects of small amounts of bovine amniotic fluid.
Topics: Amniotic Fluid; Animals; Aorta; Aspirin; Blood Pressure; Cardiac Output; Cattle; Female; Gestational | 1974 |
Pulmonary effects of induced platelet aggregation. Intravascular obstruction or vasoconstriction?
Topics: Animals; Aspirin; Blood Platelets; Blood Pressure; Cell Aggregation; Chromium Isotopes; Dogs; Emboli | 1971 |