Page last updated: 2024-10-23

aspirin and Pruritus

aspirin has been researched along with Pruritus in 34 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis."9.04Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. ( Davies, J; Dixon, AJ; Dormandy, TL; Hamilton, EB; Holt, PJ; Mason, RM; Thompson, M; Weber, JC; Zutshi, DW, 1975)
"Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present."8.86WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, G, 2010)
"Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present."8.80Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, GL, 2000)
"The effect of 900 mg aspirin on persistent itch from chronic dermatoses other than urticaria (eight patients) and other causes (five patients) was measured subjectively using a 10 cm line and objectively as nocturnal scratch using limb meters."7.67Effect of aspirin on pruritus. ( Daly, BM; Shuster, S, 1986)
"The symptom scores for flushing, itching, tingling, and warmth were all significantly reduced by both aspirin regimens (p < ."5.08Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. ( Campbell, JR; Jungnickel, PW; Maloley, PA; Peddicord, TE; Vander Tuin, EL, 1997)
"It appears from this pilot study that preceding niacin with 325 mg of aspirin will decrease the warmth and flushing associated with niacin."5.07The effect of aspirin on niacin-induced cutaneous reactions. ( Fowler, SF; Hainer, BL; Price, SO; Whelan, AM, 1992)
"Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis."5.04Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. ( Davies, J; Dixon, AJ; Dormandy, TL; Hamilton, EB; Holt, PJ; Mason, RM; Thompson, M; Weber, JC; Zutshi, DW, 1975)
"Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present."4.86WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, G, 2010)
"Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present."4.80Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, GL, 2000)
"We describe four cases of anaphylaxis to paracetamol without co-existing aspirin intolerance and review the Australian experience in paracetamol anaphylaxis."3.68Paracetamol anaphylaxis. ( Czarny, D; Leung, R; Plomley, R, 1992)
"The effect of 900 mg aspirin on persistent itch from chronic dermatoses other than urticaria (eight patients) and other causes (five patients) was measured subjectively using a 10 cm line and objectively as nocturnal scratch using limb meters."3.67Effect of aspirin on pruritus. ( Daly, BM; Shuster, S, 1986)
"Itch and pain were scored on a visual analogue scale at regular intervals."2.70Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study. ( Benfeldt, E; Jensen, SB; Menné, T; Serup, J; Thomsen, JS, 2002)
" There is a need for further research in order to come to a clear conclusion regarding combined therapies of aspirin and laropiprant pretreatment, as well as exact dosage requirements."2.45Mechanisms of flushing due to niacin and abolition of these effects. ( Arora, R; Sood, A, 2009)
"Primary delusional parasitosis is a psychiatric disorder with the delusion as an isolated manifestation, whereas secondary delusional parasitosis is a delusion occurring secondary to a psychiatric disorder, substance use, or medical illness."1.51Delusional parasitosis as presenting symptom of occipital lobe cerebrovascular accident. ( Haas, MRC; Haas, NL; Nicholson, A, 2019)
"The steroids in vernal keratoconjunctivitis (VKC) are not always effective and may result in glaucoma."1.28Evaluation of combined systemic aspirin and cromolyn sodium in intractable vernal catarrh. ( Chaudhary, KP, 1990)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199014 (41.18)18.7374
1990's6 (17.65)18.2507
2000's8 (23.53)29.6817
2010's6 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Haas, NL1
Nicholson, A1
Haas, MRC1
Reneau, JC1
Patnaik, MM1
Katagiri, K1
Kammer, RT1
Sato, S1
Nagao, R1
Hujioka, T1
Suzuki, K1
Tsuyuki, K1
Hoshika, A1
Sood, A1
Arora, R1
Young, G1
Jewell, D2
Prodanovic, EM1
Frater, JL1
Burkemper, NM1
Hurley, MY1
Macchia, L1
Caiaffa, MF1
Vacca, A1
Tursi, A1
Yosipovitch, G2
Hundley, JL1
Sugimoto, M1
Arai, I1
Futaki, N1
Hashimoto, Y1
Honma, Y1
Nakaike, S1
Fjellner, B2
Thiers, B1
Ademola, J1
Lui, P1
Amin, S1
Maibach, HI1
Jungnickel, PW1
Maloley, PA1
Vander Tuin, EL1
Peddicord, TE1
Campbell, JR1
Young, GL1
Thomsen, JS1
Benfeldt, E1
Jensen, SB1
Serup, J1
Menné, T1
Hägermark, Ö2
Dixon, AJ1
Davies, J1
Dormandy, TL1
Hamilton, EB1
Holt, PJ1
Mason, RM1
Thompson, M1
Weber, JC1
Zutshi, DW1
Read, MD1
Leung, R1
Plomley, R1
Czarny, D1
Whelan, AM1
Price, SO1
Fowler, SF1
Hainer, BL1
Chaudhary, KP1
Durand-Malgouyres, C1
Bazex, J1
Marguery, MC1
Daly, BM1
Shuster, S1
Thorne, J1
Day, SJ1
De Castro-Costa, M1
Gybels, J1
Kupers, R1
Van Hees, J1
Bigby, M1
Stern, R1
Brodthagen, H1
Thormann, J1
Veien, NK1
Lockey, SD1
Miller, WS1
Ruderman, FR1
Smith, JG1
Silberman, HR1
McGinn, TG1
Kremer, WB1

Reviews

5 reviews available for aspirin and Pruritus

ArticleYear
Mechanisms of flushing due to niacin and abolition of these effects.
    Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:11

    Topics: Aspirin; Dose-Response Relationship, Drug; Dyslipidemias; Humans; Hypolipidemic Agents; Indoles; Nia

2009
WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy.
    The Cochrane database of systematic reviews, 2010, Nov-10, Issue:11

    Topics: Antipruritics; Aspirin; Chlorpheniramine; Female; Histamine H1 Antagonists; Humans; Pregnancy; Pregn

2010
Practical guidelines for relief of itch.
    Dermatology nursing, 2004, Volume: 16, Issue:4

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Anti-Inflammatory Agents; Anti-Inflammatory Agent

2004
Antihistamines versus aspirin for itching in late pregnancy.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Antipruritics; Aspirin; Chlorpheniramine; Female; Histamine H1 Antagonists; Humans; Pregnancy; Pregn

2000
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:5 Pt 1

    Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-

1985

Trials

8 trials available for aspirin and Pruritus

ArticleYear
Experimental and clinical pruritus. Studies on some putative peripheral mediators. The influence of ultraviolet light and transcutaneous nerve stimulation.
    Acta dermato-venereologica. Supplementum, 1981, Volume: 97

    Topics: Animals; Aspirin; Electric Stimulation Therapy; Histamine Release; Humans; Intradermal Tests; Mast C

1981
Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions.
    Journal of general internal medicine, 1997, Volume: 12, Issue:10

    Topics: Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Stud

1997
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
    Acta dermato-venereologica, 2002, Volume: 82, Issue:1

    Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Me

2002
Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement.
    Acta dermato-venereologica, 1979, Volume: 59, Issue:6

    Topics: Adult; Aged; Aspirin; Blood Platelets; Clinical Trials as Topic; Double-Blind Method; Female; Histam

1979
Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.
    Annals of the rheumatic diseases, 1975, Volume: 34, Issue:5

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dyspepsia; Female; Humans;

1975
The effect of aspirin on niacin-induced cutaneous reactions.
    The Journal of family practice, 1992, Volume: 34, Issue:2

    Topics: Adult; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Flushing; Humans; Hyperlipid

1992
Influence of antihistamines, sedatives, and aspirin on experimental itch.
    Acta dermato-venereologica, 1973, Volume: 53, Issue:5

    Topics: Aspirin; Clinical Trials as Topic; Depression, Chemical; Diazepam; Erythema; Histamine; Histamine H1

1973
Aspirin and ultraviolet light-induced erythema in man.
    Archives of dermatology, 1967, Volume: 95, Issue:4

    Topics: Adult; Aspirin; Clinical Trials as Topic; Erythema; Humans; Male; Pain; Placebos; Pruritus; Ultravio

1967

Other Studies

21 other studies available for aspirin and Pruritus

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Delusional parasitosis as presenting symptom of occipital lobe cerebrovascular accident.
    The American journal of emergency medicine, 2019, Volume: 37, Issue:10

    Topics: Anticholesteremic Agents; Aspirin; Atorvastatin; Delusional Parasitosis; Female; Humans; Middle Aged

2019
47-Year-Old Man With Pruritus.
    Mayo Clinic proceedings, 2016, Volume: 91, Issue:2

    Topics: Aspirin; Diagnosis, Differential; Disease Management; Hemoglobins; Histamine Antagonists; Humans; Ja

2016
Aspirin and loxoprofen relieve refractory pruritus in patients with prurigo nodularis.
    The Journal of dermatology, 2016, Volume: 43, Issue:9

    Topics: Administration, Cutaneous; Administration, Oral; Anti-Bacterial Agents; Anti-Inflammatory Agents, No

2016
Successful clopidogrel desensitization after drug-eluting stent implantation.
    The Journal of invasive cardiology, 2009, Volume: 21, Issue:3

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Desensitization, Immunologic; Drug-Eluting Ste

2009
A case of food-dependent exercise-induced anaphylaxis due to ingestion of peach.
    Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:4

    Topics: Anaphylaxis; Antigens, Plant; Aspirin; Asthma, Exercise-Induced; Child; Cross Reactions; Dyspnea; Ep

2009
Pruritic indurated plaques on the legs of a 62-year-old woman--quiz case. Polycythemia vera (PCV).
    Archives of dermatology, 2011, Volume: 147, Issue:1

    Topics: Aspirin; Biopsy; Female; Humans; Hydroxyurea; Janus Kinase 2; Leg; Middle Aged; Point Mutation; Poly

2011
General adverse reaction to aspirin administered by transdermal iontophoresis.
    European journal of clinical pharmacology, 2002, Volume: 58, Issue:9

    Topics: Administration, Cutaneous; Adolescent; Analgesics; Angioedema; Aspirin; Cough; Dyspnea; Erythema; Hu

2002
Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice.
    Prostaglandins, leukotrienes, and essential fatty acids, 2006, Volume: 75, Issue:1

    Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epoprost

2006
Therapeutic briefs. I.
    Journal of the American Academy of Dermatology, 1980, Volume: 3, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Aspirin; Child; Cimetidine; Cyclophosphamide; Dipyridamole; Female; Hu

1980
Topically applied aspirin rapidly decreases histamine-induced itch.
    Acta dermato-venereologica, 1997, Volume: 77, Issue:1

    Topics: Administration, Topical; Adult; Aspirin; Female; Histamine; Humans; Injections, Intradermal; Male; P

1997
A new hypothesis of itching in pregnancy.
    The Practitioner, 1977, Volume: 218, Issue:1308

    Topics: Aspirin; Chlorpheniramine; Female; Humans; Liver Function Tests; Models, Biological; Pregnancy; Preg

1977
Paracetamol anaphylaxis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1992, Volume: 22, Issue:9

    Topics: Acetaminophen; Anaphylaxis; Angioedema; Aspirin; Bronchial Spasm; Cross Reactions; Humans; Hypotensi

1992
Evaluation of combined systemic aspirin and cromolyn sodium in intractable vernal catarrh.
    Annals of ophthalmology, 1990, Volume: 22, Issue:8

    Topics: Adolescent; Adult; Aspirin; Chi-Square Distribution; Child; Conjunctivitis, Allergic; Cromolyn Sodiu

1990
[Aquagenic pruritus (A.P.)].
    Allergie et immunologie, 1990, Volume: 22, Issue:7

    Topics: Acetylcholine; Age Factors; Aspirin; Bicarbonates; Fibrinolysis; Fluoxetine; Globulins; Histamine; H

1990
Effect of aspirin on pruritus.
    British medical journal (Clinical research ed.), 1986, Oct-11, Volume: 293, Issue:6552

    Topics: Adolescent; Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Pruritus; Skin Diseases

1986
Effect of aspirin on pruritus.
    British medical journal (Clinical research ed.), 1986, Dec-06, Volume: 293, Issue:6560

    Topics: Aspirin; Humans; Methods; Pruritus

1986
Scratching behaviour in arthritic rats: a sign of chronic pain or itch?
    Pain, 1987, Volume: 29, Issue:1

    Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Astemizole; Behavior, Animal; Benzimidazoles;

1987
[Letter: Urticaria. Color additives and antihistaminics].
    Ugeskrift for laeger, 1974, Jun-10, Volume: 136, Issue:24

    Topics: Angioedema; Aspirin; Azo Compounds; Benzoates; Color; Histamine H1 Antagonists; Humans; Pharmaceutic

1974
Reactions to hidden agents in foods, beverages and drugs.
    Annals of allergy, 1971, Volume: 29, Issue:9

    Topics: Adult; Allergens; Anaphylaxis; Aspirin; Asthma; Azo Compounds; Beverages; Child; Child, Preschool; C

1971
Control of fever in Hodgkin's disease by indomethacin.
    JAMA, 1965, Nov-08, Volume: 194, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Antineoplastic Agents; Aspirin; Female; Fever

1965