Page last updated: 2024-10-23

aspirin and Proteinuria

aspirin has been researched along with Proteinuria in 72 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"There was no significant difference in urinary proteinuria after 6 weeks of treatment with placebo or celecoxib (proteinuria ratio, celecoxib versus placebo, 1."9.12A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. ( Chen, H; Clyne, S; Han, E; Harris, R; Lehrich, R; Lewis, J; Middleton, J; Rodby, R; Schulman, G; Shyr, Y; Sika, M; Sinsakul, M, 2007)
"The efficacy of low-dose aspirin in preventing fetal growth retardation was tested in a randomised, placebo-controlled, double-blind trial."9.07Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial. ( Bazin, B; Beaufils, M; Breart, G; Capitant, C; Paris, J; Uzan, S, 1991)
" This study investigates the influence of aspirin plus dipyridamole on proteinuria and renal function in nephrotic MPGN patients with moderately reduced glomerular filtration rate."9.07Effect of aspirin and dipyridamole on proteinuria in idiopathic membranoproliferative glomerulonephritis: a multicentre prospective clinical trial. Collaborative Glomerulonephritis Therapy Study Group (CGTS) ( Böhler, J; Braun, N; Grupp, C; Heering, P; Schollmeyer, P; Zäuner, I, 1994)
"Our results demonstrated that the combination of quercetin and aspirin exerted significantly stronger effects than aspirin alone on decreasing systolic blood pressure and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type decidual macrophages polarization in an LPS-induced rat model of preeclampsia."8.31Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide. ( Chen, D; Ding, J; Liu, A; Yang, S, 2023)
"Treatment with curcumin and aspirin combination significantly reduced the systolic blood pressure and proteinuria in the PE rats."8.31Combining curcumin and aspirin ameliorates preeclampsia-like symptoms by inhibiting the placental TLR4/NF-κB signaling pathway in rats. ( Feng, Y; Hou, X; Ju, Y; Wang, Y; Yang, M; Yang, Y; Zhang, X; Zhu, X, 2023)
"Aspirin is a common drug for the treatment of pre-eclampsia."8.12Quercetin Supplement to Aspirin Attenuates Lipopolysaccharide-Induced Pre-eclampsia-Like Impairments in Rats Through the NLRP3 Inflammasome. ( Chen, D; Ding, J; Song, L; Yang, S; Zhang, J; Zhang, Y, 2022)
"A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter."7.75Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. ( Koren, G, 2009)
"1 The effects of aspirin, prednisolone, and indomethacin on nephrotoxic serum nephritis in rats was studied."7.66Effects of aspirin, prednisolone and indomethacin on nephrotoxic serum nephritis in the rat. ( Kurokawa, H; Sakamoto, K, 1982)
" In nephrotoxic serum nephritis, seromucoid levels were correlated with the proteinuria of the autologous phase and were found to be a good complementary criterion for the analysis of the efficiency of pyridinol carbamate, colchicine, iysine acetylsalicylate, and L-asparaginase."7.65Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate. ( Engler, R; Feret, J; Grochulski, A; Jayle, MF; Lagrue, G; Moisy, M; Peyroux, J; Sternberg, M, 1975)
"Treatment with indomethacin, aspirin, or prednisone has been shown to reduce urinary fibrin/fibrinogen degradation products (F."6.64Modification by drugs of urinary fibrin/fibrinogen degradation products in glomerulonephritis. ( Cash, JD; Clarkson, AR; MacDonald, MK; Robson, JS, 1972)
"Quercetin is a bioflavonoid which has anti-oxidant and reno-protective abilities."5.51Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. ( Ma, Y; Shi, X; Song, L; Yang, S; Zhao, N, 2019)
"They found that in the course of treatment proteinuria did not change and glomerular filtration declined insignificantly."5.28[The effect of acetylsalicylic acid and dipyridamole on glomerular filtration and proteinuria in chronic glomerulonephritis]. ( Jáchymová, M; Knotková, V; Nĕmecek, K; Petrů, I, 1990)
" The following were consistently recommended: (1) automated blood pressure measurement with devices validated for pregnancy and preeclampsia, reflecting increasing recognition of the prevalence of white-coat hypertension and the potential usefulness of home blood pressure monitoring; (2) use of dipstick proteinuria testing for screening followed by quantitative testing by urinary protein-to-creatinine ratio or 24-hour urine collection; (3) key definitions and most aspects of classification, including a broad definition of preeclampsia (which includes proteinuria and maternal end-organ dysfunction, including headache and visual symptoms and laboratory abnormalities of platelets, creatinine, or liver enzymes) and a recognition that it can worsen after delivery; (4) preeclampsia prevention with aspirin; (5) treatment of severe hypertension, most commonly with intravenous labetalol, oral nifedipine, or intravenous hydralazine; (6) treatment for nonsevere hypertension when undertaken, with oral labetalol (in particular), methyldopa, or nifedipine, with recommendations against the use of renin-angiotensin-aldosterone inhibitors; (7) magnesium sulfate for eclampsia treatment and prevention among women with "severe" preeclampsia; (8) antenatal corticosteroids for preterm birth but not hemolysis, elevated liver enzymes, and low platelet count syndrome; (9) delivery at term for preeclampsia; (10) a focus on usual labor and delivery care but avoidance of ergometrine; and (11) an appreciation that long-term health complications are increased in incidence, mandating lifestyle change and risk factor modification."5.22Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension. ( Gillon, TE; Magee, LA; Pels, A; Scott, G; von Dadelszen, P, 2022)
" During the randomized phase, there were small but significant differences between the groups in BP, proteinuria, LDL cholesterol, and use of aspirin, statins, active vitamin D, and antihypertensive medications, in favor of the intervention group."5.19Nurse practitioner care improves renal outcome in patients with CKD. ( Blankestijn, PJ; Bots, ML; Kaasjager, KA; Ligtenberg, G; Peeters, MJ; Sijpkens, YW; Sluiter, HE; Ten Dam, MA; van Buren, M; van de Ven, PJ; van den Brand, JA; van Zuilen, AD; Vervoort, G; Vleming, LJ; Wetzels, JF, 2014)
"There was no significant difference in urinary proteinuria after 6 weeks of treatment with placebo or celecoxib (proteinuria ratio, celecoxib versus placebo, 1."5.12A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. ( Chen, H; Clyne, S; Han, E; Harris, R; Lehrich, R; Lewis, J; Middleton, J; Rodby, R; Schulman, G; Shyr, Y; Sika, M; Sinsakul, M, 2007)
"This was a prospective observation of pregnancy outcomes among 462 women with pregestational diabetes mellitus (White classes B-F) and singleton pregnancies who were enrolled in a multicenter trial to compare low-dose aspirin with placebo for preeclampsia prevention."5.09Risks of preeclampsia and adverse neonatal outcomes among women with pregestational diabetes mellitus. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. ( Caritis, S; Dombrowski, M; Hauth, J; Klebanoff, M; Landon, M; Lindheimer, M; MacPherson, C; McNellis, D; Meis, P; Miodovnik, M; Paul, R; Roberts, J; Sibai, BM; Thurnau, G; VanDorsten, JP, 2000)
" This study investigates the influence of aspirin plus dipyridamole on proteinuria and renal function in nephrotic MPGN patients with moderately reduced glomerular filtration rate."5.07Effect of aspirin and dipyridamole on proteinuria in idiopathic membranoproliferative glomerulonephritis: a multicentre prospective clinical trial. Collaborative Glomerulonephritis Therapy Study Group (CGTS) ( Böhler, J; Braun, N; Grupp, C; Heering, P; Schollmeyer, P; Zäuner, I, 1994)
"The efficacy of low-dose aspirin in preventing fetal growth retardation was tested in a randomised, placebo-controlled, double-blind trial."5.07Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial. ( Bazin, B; Beaufils, M; Breart, G; Capitant, C; Paris, J; Uzan, S, 1991)
"The present review focuses on the roles of thromboxane A2 (TxA2) in arterial thrombosis, atherogenesis, vascular stent-related ischemic events and renal proteinuria."4.85Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases. ( Alberts, P; Bounameaux, H; Fontana, P; Mann, J; Sakariassen, KS; Sorensen, AS, 2009)
"Our results demonstrated that the combination of quercetin and aspirin exerted significantly stronger effects than aspirin alone on decreasing systolic blood pressure and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type decidual macrophages polarization in an LPS-induced rat model of preeclampsia."4.31Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide. ( Chen, D; Ding, J; Liu, A; Yang, S, 2023)
"Treatment with curcumin and aspirin combination significantly reduced the systolic blood pressure and proteinuria in the PE rats."4.31Combining curcumin and aspirin ameliorates preeclampsia-like symptoms by inhibiting the placental TLR4/NF-κB signaling pathway in rats. ( Feng, Y; Hou, X; Ju, Y; Wang, Y; Yang, M; Yang, Y; Zhang, X; Zhu, X, 2023)
"Aspirin is a common drug for the treatment of pre-eclampsia."4.12Quercetin Supplement to Aspirin Attenuates Lipopolysaccharide-Induced Pre-eclampsia-Like Impairments in Rats Through the NLRP3 Inflammasome. ( Chen, D; Ding, J; Song, L; Yang, S; Zhang, J; Zhang, Y, 2022)
" Therapeutic strategies using lipid mediators, such as aspirin-triggered resolvin D1 (ATRvD1), can contribute to the resolution of acute and chronic inflammation."4.02ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice. ( Almeida-Souza, F; Benjamim, CF; Calabrese, KS; Calcia, TBB; Caruso-Neves, C; Guilherme, RF; Lemos, FS; Neves, JS; Silva, CP; Silva, JBNF, 2021)
"A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter."3.75Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. ( Koren, G, 2009)
" This study investigates the effect of acetylsalicylic acid (ASA) combined with dipyridamole on proteinuria and renal function in nephrotic MPGN patients with normal/moderately reduced glomerular filtration rate (GFR)."3.71Effect of acetylsalicylic acid and dipyridamole in primary membranoproliferative glomerulonephritis type I. ( Baştürk, T; Harmankaya, O; Karabiber, N; Obek, A; Oztürk, Y, 2001)
"1 The effects of aspirin, prednisolone, and indomethacin on nephrotoxic serum nephritis in rats was studied."3.66Effects of aspirin, prednisolone and indomethacin on nephrotoxic serum nephritis in the rat. ( Kurokawa, H; Sakamoto, K, 1982)
" In nephrotoxic serum nephritis, seromucoid levels were correlated with the proteinuria of the autologous phase and were found to be a good complementary criterion for the analysis of the efficiency of pyridinol carbamate, colchicine, iysine acetylsalicylate, and L-asparaginase."3.65Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate. ( Engler, R; Feret, J; Grochulski, A; Jayle, MF; Lagrue, G; Moisy, M; Peyroux, J; Sternberg, M, 1975)
" There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis."3.65Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973)
"Renal function was studied in 17 patients with rheumatoid arthritis who had each consumed between 5 and 20 kg of aspirin."3.65Aspirin and analgesic nephropathy. ( Craft, AW; Kerr, DN; Macklon, AF; Thompson, M, 1974)
"Proteinuria was independently associated with the incidence of primary cardiovascular events in diabetic patients."2.94Proteinuria is independently associated with the incidence of primary cardiovascular events in diabetic patients. ( Jinnouchi, H; Masuda, I; Matsumoto, C; Morimoto, T; Nakayama, M; Ogawa, H; Okada, S; Saito, Y; Soejima, H; Waki, M, 2020)
"Treatment with indomethacin, aspirin, or prednisone has been shown to reduce urinary fibrin/fibrinogen degradation products (F."2.64Modification by drugs of urinary fibrin/fibrinogen degradation products in glomerulonephritis. ( Cash, JD; Clarkson, AR; MacDonald, MK; Robson, JS, 1972)
" Avoidance of nephrotoxic and teratogenic medications is necessary, and renal dosing of commonly used medications must also be considered."2.61Chronic Kidney Disease and Pregnancy. ( Hladunewich, MA; Hui, D, 2019)
"Quercetin is a bioflavonoid which has anti-oxidant and reno-protective abilities."1.51Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. ( Ma, Y; Shi, X; Song, L; Yang, S; Zhao, N, 2019)
"We enrolled 35 patients with MPGN type 1 who had a normal creatinine clearance at the time of their first renal biopsy and divided them into 2 groups based on clinical status at the time of their most recent examination: 12 patients with normal urine test results and 12 patients with minor urinary abnormalities at the latest observation (group 1) and 7 patients with persistent nephropathy and 4 patients with renal insufficiency (group 2)."1.33Myeloid-related protein 8 expression on macrophages is a useful prognostic marker for renal dysfunction in children with MPGN type 1. ( Hosoya, M; Isome, M; Kawasaki, Y; Suzuki, H; Takahashi, A; Tanji, M, 2005)
"Treatment with dipyridamole alone or with aspirin produced significant inhibition of platelet aggregation and a fall in 24-h protein excretion; the latter amounted to 54% with dipyridamole alone and 56% with dipyridamole plus aspirin (NS)."1.28Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis. ( Cámara, S; De La Cruz, JP; Frutos, MA; Sánchez De La Cuesta, F, 1992)
"They found that in the course of treatment proteinuria did not change and glomerular filtration declined insignificantly."1.28[The effect of acetylsalicylic acid and dipyridamole on glomerular filtration and proteinuria in chronic glomerulonephritis]. ( Jáchymová, M; Knotková, V; Nĕmecek, K; Petrů, I, 1990)
"In patients with preeclampsia the renal excretion of beta 2-microglobulin allows to differentiate between a primary preeclampsia and a preeclampsia superimposed upon chronic pyelonephritis."1.26Beta 2-microglobulin and other proteins as parameter for tubular function. ( Jaques, G; Keller, M; Mondorf, AW; Prüfer, D; Weise, M, 1981)
"Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels."1.26Aspirin and analgesic nephropathy. ( Emkey, RD; Mills, JA, 1982)
"Rats treated with indomethacin showed a marked decrease of proteinuria (tested by the 3% sulfosalicylic aicd method) and a clear ultrastructural picture of hyperplasia and hypertrophy of podocytes."1.26Indomethacin and lysine acetylsalicylate in rats with autologous nephrotoxic serum nephritis. Biochemical and morphological studies. ( Cioffi, A; Conte, F; Di Belgiojoso, GB; Donati, MB; Saruggia, M; Sessa, A, 1978)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-199032 (44.44)18.7374
1990's11 (15.28)18.2507
2000's15 (20.83)29.6817
2010's8 (11.11)24.3611
2020's6 (8.33)2.80

Authors

AuthorsStudies
Silva, JBNF1
Calcia, TBB1
Silva, CP1
Guilherme, RF1
Almeida-Souza, F1
Lemos, FS1
Calabrese, KS1
Caruso-Neves, C1
Neves, JS1
Benjamim, CF1
Chen, D2
Yang, S3
Ding, J2
Liu, A1
Zhang, J1
Zhang, Y1
Song, L2
Ju, Y1
Feng, Y1
Yang, Y1
Hou, X1
Zhang, X1
Zhu, X1
Wang, Y1
Yang, M1
Soejima, H1
Ogawa, H1
Morimoto, T1
Okada, S1
Matsumoto, C1
Nakayama, M1
Masuda, I1
Jinnouchi, H1
Waki, M1
Saito, Y1
Scott, G1
Gillon, TE1
Pels, A1
von Dadelszen, P2
Magee, LA2
Chung, EYM1
Tiku, A1
Seeho, S1
Mather, A1
Shi, X1
Zhao, N1
Ma, Y1
Hui, D1
Hladunewich, MA1
Peeters, MJ1
van Zuilen, AD1
van den Brand, JA1
Bots, ML1
van Buren, M1
Ten Dam, MA1
Kaasjager, KA1
Ligtenberg, G1
Sijpkens, YW1
Sluiter, HE1
van de Ven, PJ1
Vervoort, G1
Vleming, LJ1
Blankestijn, PJ1
Wetzels, JF1
Liu, M1
Li, XC1
Lu, L1
Cao, Y1
Sun, RR1
Chen, S1
Zhang, PY1
Davila, CD1
Vargas, F1
Huang, KH1
Monaco, T1
Dimou, A1
Rangaswami, J1
Figueredo, VM1
Koren, G1
Sakariassen, KS1
Alberts, P1
Fontana, P1
Mann, J1
Bounameaux, H1
Sorensen, AS1
Ge, FJ1
Xu, JM1
Harmankaya, O1
Baştürk, T1
Oztürk, Y1
Karabiber, N1
Obek, A1
RAMSAY, AG1
WHITE, DF1
Kawasaki, Y1
Hosoya, M1
Takahashi, A1
Isome, M1
Tanji, M1
Suzuki, H1
Xu, S1
Jiang, B1
Maitland, KA1
Bayat, H1
Gu, J1
Nadler, JL1
Corda, S1
Lavielle, G1
Verbeuren, TJ1
Zuccollo, A1
Cohen, RA1
Garcia-Donaire, JA1
Ruilope, LM1
Shin, JI1
Lee, JS1
Camargo, EG1
Weinert, LS1
Lavinsky, J1
Gross, JL1
Silveiro, SP1
Shekelle, P1
Vijan, S1
Sinsakul, M1
Sika, M1
Rodby, R1
Middleton, J1
Shyr, Y1
Chen, H1
Han, E1
Lehrich, R1
Clyne, S1
Schulman, G1
Harris, R1
Lewis, J1
Weise, M1
Prüfer, D1
Jaques, G1
Keller, M1
Mondorf, AW1
Garin, EH1
Richard, GA1
Ogawa, S1
Naruse, T1
Aul, C1
Scharf, RE1
Königshausen, T1
Küppers, H1
Grabensee, B1
Emkey, RD1
Mills, JA1
Kurokawa, H1
Sakamoto, K1
Rasmussen, S1
Petersen, J1
Nielsen, IL1
Christensen, P1
Hilden, T1
Tunbridge, RD1
Zäuner, I1
Böhler, J1
Braun, N1
Grupp, C1
Heering, P1
Schollmeyer, P1
De Cosmo, S1
Earle, K1
Morocutti, A1
Walker, J1
Ruggenenti, P1
Remuzzi, G2
Viberti, GC1
Faas, MM1
Schuiling, GA1
Baller, JF1
Valkhof, N1
Bakker, WW1
Sibai, BM1
Caritis, S2
Hauth, J1
Lindheimer, M1
VanDorsten, JP2
MacPherson, C2
Klebanoff, M2
Landon, M2
Miodovnik, M2
Paul, R2
Meis, P2
Dombrowski, M1
Thurnau, G2
Roberts, J1
McNellis, D1
Branch, DW1
Porter, TF1
Rittenhouse, L1
Sibai, B1
Hogg, B1
Lindheimer, MD1
Zaman, Z1
Roggeman, S1
Cappelletti, P1
Ferrai, G1
Buxeda, M1
Barba, N1
Makino, H1
Tanaka, I1
Mukoyama, M1
Sugawara, A1
Mori, K1
Muro, S1
Suganami, T1
Yahata, K1
Ishibashi, R1
Ohuchida, S1
Maruyama, T1
Narumiya, S1
Nakao, K1
Kupor, LR1
Lowance, DC1
McPhaul, JJ1
Hormaechea, E1
Carlson, RW1
Rogove, H1
Uphold, J1
Henning, RJ1
Weil, MH1
Sessa, A1
Cioffi, A1
Conte, F1
Saruggia, M1
Di Belgiojoso, GB1
Donati, MB1
Sternberg, M1
Peyroux, J1
Grochulski, A1
Engler, R1
Feret, J1
Moisy, M1
Lagrue, G1
Jayle, MF1
De La Cruz, JP1
Cámara, S1
Frutos, MA1
Sánchez De La Cuesta, F1
Gordge, MP1
Rylance, PB1
Neild, GH1
Uzan, S1
Beaufils, M1
Breart, G1
Bazin, B1
Capitant, C1
Paris, J1
Knotková, V2
Petrů, I2
Nĕmecek, K2
Jáchymová, M2
Szer, IS1
Goldenstein-Schainberg, C1
Kurtin, PS1
McParland, P1
Pearce, JM1
Chamberlain, GV1
Hopper, AH1
Tindall, H1
Davies, JA1
Zoja, C1
Benigni, A1
Livio, M1
Bergamelli, A1
Orisio, S1
Abbate, M1
Bertani, T1
Hachicha, J1
Ammous, A1
Damak, J1
Hammami, M1
Ghorbel, A1
Rekik, S1
Jarraya, A1
Ehrich, JH1
Wurster, U1
Lütge, M1
Doehring, E1
Oemar, B1
Donadio, JV1
Ilstrup, DM1
Holley, KE1
Romero, JC1
Husted, SE1
Nielsen, HK1
Petersen, T1
Mogensen, CE1
Geday, E1
Bang, NU1
Trygstad, W1
Schroeder, JE1
Heidenreich, RO1
Csiscko, BM1
Bailey, RR1
Neale, TJ1
Little, PJ1
Zachariae, E1
Sylvest, J1
George, CR1
Slichter, SJ1
Quadracci, LJ1
Striker, GE1
Harker, LA1
Rosenmann, E1
Dishon, T1
Boss, JH1
Harrison, JF1
Parker, RW1
De Silva, KL1
Burry, HC1
Macklon, AF1
Craft, AW1
Thompson, M1
Kerr, DN1
Snapper, I1
van Ormondt Tillema, A1
Diamond, I1
Seld, D1
Kwaan, HC1
Colwell, JA1
Cruz, S1
Suwanwela, N1
Dobbie, JG1
Clarkson, AR1
MacDonald, MK1
Cash, JD1
Robson, JS1
Randall, RE1
Stacy, WK1
Toone, EC1
Prout, GR1
Madge, GE1
Shadomy, HJ1
Shadomy, S1
Utz, JP1
Wajcner, G1
Guedon, J1
Chapman, A1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis[NCT04527640]60 participants (Anticipated)Interventional2020-09-15Not yet recruiting
[NCT00065559]30 participants Interventional2003-04-30Terminated
Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513]414 participants (Anticipated)Interventional2022-03-24Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for aspirin and Proteinuria

ArticleYear
Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
    American journal of obstetrics and gynecology, 2022, Volume: 226, Issue:2S

    Topics: Anticonvulsants; Antihypertensive Agents; Aspirin; Calcium; Delivery, Obstetric; Female; Glucocortic

2022
Chronic Kidney Disease and Pregnancy.
    Obstetrics and gynecology, 2019, Volume: 133, Issue:6

    Topics: Aspirin; Female; Glomerular Filtration Rate; Humans; Hypertension, Pregnancy-Induced; Infant, Newbor

2019
Cardiovascular disease and its relationship with chronic kidney disease.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:19

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Blood Pressure; Cardiovascular Diseases;

2014
Preventing deaths due to the hypertensive disorders of pregnancy.
    Best practice & research. Clinical obstetrics & gynaecology, 2016, Volume: 36

    Topics: Aspirin; Birth Intervals; Calcium; Cardiotocography; Dietary Supplements; Eclampsia; Female; Food Su

2016
Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.
    Future cardiology, 2009, Volume: 5, Issue:5

    Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Humans;

2009
[Generation mechanisms and management strategies of adverse reactions to Bevacizumab during cancer treatment].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:7

    Topics: Angiogenesis Inhibitors; Angiotensin-Converting Enzyme Inhibitors; Antibodies, Monoclonal; Antibodie

2010
Spotlight on renin: cardiovascular outcomes in chronic kidney disease and suppression of the renin-angiotensin system.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2006, Volume: 7, Issue:1

    Topics: Albuminuria; Aspirin; Cardiovascular Diseases; Chronic Disease; Glomerular Filtration Rate; Humans;

2006
Quality indicators for the care of diabetes mellitus in vulnerable elders.
    Journal of the American Geriatrics Society, 2007, Volume: 55 Suppl 2

    Topics: Aged; Aspirin; Diabetes Complications; Diabetes Mellitus; Evidence-Based Medicine; Frail Elderly; Gl

2007
The management of pregnancy in hypertensive patients.
    Postgraduate medical journal, 1994, Volume: 70, Issue:829

    Topics: Adult; Antihypertensive Agents; Aspirin; Blood Pressure; Congenital Abnormalities; Female; Humans; H

1994

Trials

12 trials available for aspirin and Proteinuria

ArticleYear
Proteinuria is independently associated with the incidence of primary cardiovascular events in diabetic patients.
    Journal of cardiology, 2020, Volume: 75, Issue:4

    Topics: Aged; Aspirin; Cardiovascular Diseases; Diabetes Mellitus; Female; Fibrinolytic Agents; Humans; Inci

2020
Nurse practitioner care improves renal outcome in patients with CKD.
    Journal of the American Society of Nephrology : JASN, 2014, Volume: 25, Issue:2

    Topics: Aged; Ambulatory Care Facilities; Antihypertensive Agents; Aspirin; Biomarkers; Cholesterol, LDL; Cr

2014
The effect of aspirin on the antiproteinuric properties of enalapril in microalbuminuric type 2 diabetic patients: a randomized, double-blind, placebo-controlled study.
    Diabetes care, 2007, Volume: 30, Issue:7

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Agents; Cross-Over Studies;

2007
A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2007, Volume: 50, Issue:6

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Celecoxib; Creatinine; Cross-Over Studies;

2007
Effect of aspirin and dipyridamole on proteinuria in idiopathic membranoproliferative glomerulonephritis: a multicentre prospective clinical trial. Collaborative Glomerulonephritis Therapy Study Group (CGTS)
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Aspirin; Blood Pressure; Dietary Proteins;

1994
Glucose-induced changes in renal haemodynamics in proteinuric type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion.
    Diabetologia, 1993, Volume: 36, Issue:7

    Topics: Adult; Analysis of Variance; Aspirin; Biopsy; Blood Proteins; Diabetes Mellitus, Type 1; Diabetic Ne

1993
Risks of preeclampsia and adverse neonatal outcomes among women with pregestational diabetes mellitus. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.
    American journal of obstetrics and gynecology, 2000, Volume: 182, Issue:2

    Topics: Aspirin; Birth Weight; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female;

2000
Prevention of fetal growth retardation with low-dose aspirin: findings of the EPREDA trial.
    Lancet (London, England), 1991, Jun-15, Volume: 337, Issue:8755

    Topics: Adult; Aspirin; Birth Weight; Dipyridamole; Double-Blind Method; Drug Administration Schedule; Drug

1991
Doppler ultrasound and aspirin in recognition and prevention of pregnancy-induced hypertension.
    Lancet (London, England), 1990, Jun-30, Volume: 335, Issue:8705

    Topics: Administration, Oral; Adult; Aspirin; Blood Platelets; Drug Administration Schedule; Drug Evaluation

1990
Administration of aspirin-dipyridamole reduces proteinuria in diabetic nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1989, Volume: 4, Issue:2

    Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dipyridamole; Double-Blind Method

1989
Osteoarthritis of the knee treated with tolfenamic acid.
    Scandinavian journal of rheumatology, 1972, Volume: 1, Issue:3

    Topics: Adult; Aged; Alanine Transaminase; Aspirin; Body Weight; Clinical Trials as Topic; Creatinine; Femal

1972
Modification by drugs of urinary fibrin/fibrinogen degradation products in glomerulonephritis.
    British medical journal, 1972, Jul-29, Volume: 3, Issue:5821

    Topics: Adolescent; Adult; Aged; Aspirin; Child; Creatinine; Female; Fibrin; Fibrinogen; Glomerulonephritis;

1972

Other Studies

51 other studies available for aspirin and Proteinuria

ArticleYear
ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice.
    International journal of molecular sciences, 2021, Oct-27, Volume: 22, Issue:21

    Topics: Acute Kidney Injury; Albumins; Animals; Aspirin; Biomarkers; Cytokines; Disease Models, Animal; Doco

2021
Natural Flavonoid Quercetin Enhances the Anti-inflammatory Effects of Aspirin in a Preeclampsia-like Rat Model Induced by Lipopolysaccharide.
    Current molecular medicine, 2023, Volume: 23, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Flavonoids; Humans; Lipo

2023
Quercetin Supplement to Aspirin Attenuates Lipopolysaccharide-Induced Pre-eclampsia-Like Impairments in Rats Through the NLRP3 Inflammasome.
    Drugs in R&D, 2022, Volume: 22, Issue:4

    Topics: Animals; Aspirin; Caspase 1; Dietary Supplements; Female; Humans; Inflammasomes; Lipopolysaccharides

2022
Combining curcumin and aspirin ameliorates preeclampsia-like symptoms by inhibiting the placental TLR4/NF-κB signaling pathway in rats.
    The journal of obstetrics and gynaecology research, 2023, Volume: 49, Issue:1

    Topics: Animals; Aspirin; Curcumin; Female; Humans; NF-kappa B; Placenta; Placenta Growth Factor; Pre-Eclamp

2023
Significant infrarenal aortic stenosis in pregnancy: a case report.
    Journal of medical case reports, 2019, May-01, Volume: 13, Issue:1

    Topics: Adult; Aortic Valve Stenosis; Aspirin; Calcium; Calcium-Regulating Hormones and Agents; Cesarean Sec

2019
Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 116

    Topics: Animals; Aspirin; Blood Pressure; Cytokines; Dietary Supplements; Disease Models, Animal; Female; In

2019
Dipstick proteinuria is an independent predictor of high on treatment platelet reactivity in patients on clopidogrel, but not aspirin, admitted for major adverse cardiovascular events.
    Platelets, 2015, Volume: 26, Issue:7

    Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cohort Stud

2015
Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Progression; Female; Hearing Loss;

2009
Effect of acetylsalicylic acid and dipyridamole in primary membranoproliferative glomerulonephritis type I.
    International urology and nephrology, 2001, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Creatinine; Dipyridamole; Drug

2001
PHENACETIN NEPHROPATHY.
    Canadian Medical Association journal, 1965, Jan-09, Volume: 92

    Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy

1965
Consensus statement for the prevention of vascular disease.
    Australian family physician, 2004, Volume: 33, Issue:4

    Topics: Aged; Aspirin; Atrial Fibrillation; Australia; Diabetes Complications; Diabetes Mellitus; Family Pra

2004
Myeloid-related protein 8 expression on macrophages is a useful prognostic marker for renal dysfunction in children with MPGN type 1.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3

    Topics: Adolescent; Aspirin; Biomarkers; Biopsy; Calgranulin A; Calgranulin B; Child; Creatinine; Cyclophosp

2005
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.
    Diabetes, 2006, Volume: 55, Issue:1

    Topics: Animals; Apolipoproteins E; Arachidonate 12-Lipoxygenase; Aspirin; Diabetes Mellitus, Experimental;

2006
Can chronic fatigue symptoms associated with nutcracker phenomenon be treated with aspirin?
    Medical hypotheses, 2007, Volume: 69, Issue:3

    Topics: Adolescent; Angioplasty, Balloon; Aorta; Aspirin; Child; Child, Preschool; Fatigue; Fatigue Syndrome

2007
Beta 2-microglobulin and other proteins as parameter for tubular function.
    Contributions to nephrology, 1981, Volume: 24

    Topics: Acetaminophen; Amino Acid Sequence; Aspirin; beta 2-Microglobulin; Beta-Globulins; Female; Graft Rej

1981
Prostaglandin synthesis inhibitors and primary antibody response in experimental nephrotic syndrome.
    Clinical immunology and immunopathology, 1984, Volume: 30, Issue:1

    Topics: Animals; Antibody-Producing Cells; Aspirin; Hemolytic Plaque Technique; Indomethacin; Isoantibodies;

1984
Effects of various antiplatelet drugs and defibrinating agent on experimental glomerulonephritis in rats.
    The Journal of laboratory and clinical medicine, 1982, Volume: 99, Issue:3

    Topics: Animals; Anticoagulants; Aspirin; Batroxobin; Blood Platelets; Dipyridamole; Glomerulonephritis; Imm

1982
[Differential therapy of thrombotic-thrombopenic purpura. Administration of fresh plasma versus plasma separation].
    Deutsche medizinische Wochenschrift (1946), 1984, Dec-14, Volume: 109, Issue:50

    Topics: Acute Kidney Injury; Adult; Aspirin; Blood Platelets; Blood Transfusion; Dipyridamole; Erythrocytes;

1984
Aspirin and analgesic nephropathy.
    JAMA, 1982, Jan-01, Volume: 247, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Creatinine; Female; History, 17th Century; Humans; Kidn

1982
Effects of aspirin, prednisolone and indomethacin on nephrotoxic serum nephritis in the rat.
    British journal of pharmacology, 1982, Volume: 75, Issue:1

    Topics: Animals; Aspirin; Indomethacin; Kidney; Kidney Function Tests; Male; Nephritis; Prednisolone; Protei

1982
Effect of acetylsalicylic acid on renal function in systemic lupus erythematosus.
    European journal of clinical pharmacology, 1982, Volume: 23, Issue:6

    Topics: Adult; Aged; Aspirin; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Functio

1982
Aspirin treatment of the low-dose-endotoxin-treated pregnant rat: pathophysiologic and immunohistologic aspects.
    The Journal of laboratory and clinical medicine, 1997, Volume: 130, Issue:5

    Topics: Albuminuria; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apyrase; Aspirin; Blood Pressure; Cel

1997
Antiphospholipid antibodies in women at risk for preeclampsia.
    American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:5

    Topics: Adult; Antibodies, Anticardiolipin; Antibodies, Antiphospholipid; Aspirin; Blood Pressure; Enzyme-Li

2001
Evaluation of Aution Max AX-4280 automated urine test-strip analyser.
    Clinical chemistry and laboratory medicine, 2001, Volume: 39, Issue:7

    Topics: Ascorbic Acid; Aspirin; Chemistry, Clinical; Glucose; Hematuria; Humans; Hydrogen-Ion Concentration;

2001
Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:7

    Topics: Animals; Aspirin; Autocrine Communication; Cells, Cultured; Cinnamates; Cyclooxygenase Inhibitors; D

2002
Single and multiple drug therapy in autologous immune complex nephritis in rats.
    The Journal of laboratory and clinical medicine, 1976, Volume: 87, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azathioprine; Basement Membrane; Compleme

1976
Hypovolemia, pulmonary edema and protein changes in severe salicylate poisoning.
    The American journal of medicine, 1979, Volume: 66, Issue:6

    Topics: Adult; Aspirin; Blood Pressure; Blood Proteins; Blood Volume; Female; Hematocrit; Humans; Hypoprotei

1979
Indomethacin and lysine acetylsalicylate in rats with autologous nephrotoxic serum nephritis. Biochemical and morphological studies.
    Nephron, 1978, Volume: 22, Issue:4-6

    Topics: Animals; Aspirin; Basement Membrane; Disease Models, Animal; Female; Glomerulonephritis; Immune Sera

1978
Biochemical criteria for the evaluation of drug efficiency on adjuvant arthritis and nephrotoxic serum nephritis in the rat: studies with phenylbutazone, L-Asparaginase, colchicine, lysine acetylsalicylate, and pyridinol carbamate.
    Canadian journal of physiology and pharmacology, 1975, Volume: 53, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Asparaginase; Aspirin; Basement Membrane; Blood Proteins; Carbamates

1975
Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:3

    Topics: Adult; Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Glomerulonephritis, Membranous; Hum

1992
Anti-platelet therapy in diabetic and non-diabetic progressive renal failure.
    Clinical nephrology, 1992, Volume: 37, Issue:1

    Topics: Aspirin; Blood Pressure; Creatinine; Diabetic Nephropathies; Dipyridamole; Docosahexaenoic Acids; Dr

1992
[The effect of decreased thromboxane synthesis on proliferative glomerulonephritis].
    Casopis lekaru ceskych, 1991, Oct-18, Volume: 130, Issue:16-17

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Chronic Disease; Creatinine; Female; Glomerular Filtra

1991
Paucity of renal complications associated with nonsteroidal antiinflammatory drugs in children with chronic arthritis.
    The Journal of pediatrics, 1991, Volume: 119, Issue:5

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Aspirin; Child; Child, Pre

1991
[The effect of acetylsalicylic acid and dipyridamole on glomerular filtration and proteinuria in chronic glomerulonephritis].
    Vnitrni lekarstvi, 1990, Volume: 36, Issue:4

    Topics: Adult; Aspirin; Chronic Disease; Dipyridamole; Female; Glomerular Filtration Rate; Glomerulonephriti

1990
Selective inhibition of platelet thromboxane generation with low-dose aspirin does not protect rats with reduced renal mass from the development of progressive disease.
    The American journal of pathology, 1989, Volume: 134, Issue:5

    Topics: Animals; Aspirin; Blood Platelets; Kidney; Kidney Diseases; Kidney Glomerulus; Male; Platelet Aggreg

1989
[Prevention of complications of severe arterial hypertension in pregnancy using platelet antiaggregants].
    Presse medicale (Paris, France : 1983), 1989, Apr-15, Volume: 18, Issue:15

    Topics: Adult; Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Humans; Hypertension; Pregnancy; Pr

1989
[Enzymuria and kidney diseases in childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:12

    Topics: Acetylglucosaminidase; Adolescent; Aminopeptidases; Anti-Bacterial Agents; Aspirin; CD13 Antigens; C

1986
Platelet-inhibitor treatment of diabetic nephropathy: a 10-year prospective study.
    Mayo Clinic proceedings, 1988, Volume: 63, Issue:1

    Topics: Adult; Aspirin; Blood Platelets; Cell Survival; Creatinine; Diabetic Nephropathies; Dipyridamole; Dr

1988
Acute effects of acetylsalicylic acid on renal and hepatic function in normal humans.
    International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Alanine Transaminase; Albuminuria; Aspartate Aminotransferases; Aspirin; beta 2-M

1985
Enhanced platelet function in glomerular renal disease.
    The Journal of laboratory and clinical medicine, 1973, Volume: 81, Issue:5

    Topics: Adenosine Diphosphate; Adolescent; Aspirin; Beta-Globulins; Blood Cell Count; Blood Platelets; Child

1973
Analgesic nephropathy.
    The New Zealand medical journal, 1974, Jun-26, Volume: 79, Issue:518

    Topics: Adult; Aged; Analgesics; Anemia; Aspirin; Codeine; Drug Combinations; Female; Follow-Up Studies; Hum

1974
A kinetic evaluation of hemostasis in renal disease.
    The New England journal of medicine, 1974, Nov-21, Volume: 291, Issue:21

    Topics: Aspirin; Blood Coagulation; Complement System Proteins; Diabetic Nephropathies; Dipyridamole; Fibrin

1974
Urinary excretion of kidney antigens in rats consuming analgesics.
    Pathologia Europaea, 1972, Volume: 7, Issue:2

    Topics: Animals; Antigens; Aspirin; Diet; Female; Immune Sera; Immunodiffusion; Kidney Diseases; Kidney Tubu

1972
Lysozymuria and acute disorders of renal function.
    Journal of clinical pathology, 1973, Volume: 26, Issue:4

    Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo

1973
Drug-induced nephropathies.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:9

    Topics: Animals; Arthritis, Rheumatoid; Aspirin; Colic; Complement System Proteins; Glomerular Filtration Ra

1973
Editorial: Analgesic nephropathy or phenacetin poisoning.
    British medical journal, 1974, Mar-30, Volume: 1, Issue:5908

    Topics: Animals; Aspirin; Humans; Kidney Failure, Chronic; Phenacetin; Proteinuria; Rats; Substance-Related

1974
Aspirin and analgesic nephropathy.
    British medical journal, 1974, Mar-30, Volume: 1, Issue:5908

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Blood Pressure; Creatinine; Female; Humans; Kidney Dise

1974
On the heterogeneity of Bence Jones protein.
    Acta haematologica, 1969, Volume: 41, Issue:1

    Topics: Acrylates; Antigens; Aspirin; Bence Jones Protein; Chemical Precipitation; Electrophoresis; Gels; Hu

1969
Increased platelet aggregation in diabetes mellitus.
    The Journal of laboratory and clinical medicine, 1972, Volume: 80, Issue:2

    Topics: Adenosine Diphosphate; Aspirin; Blood Chemical Analysis; Blood Proteins; Creatinine; Diabetes Mellit

1972
Cryptococcal pyelonephritis.
    The New England journal of medicine, 1968, Jul-11, Volume: 279, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Aged; Amphotericin B; Arthritis, Rheumatoid; Aspirin; Cryptococcosis

1968
[Acute anuric renal insufficiency with necrosing arteriolitis. Etiologic problems].
    Journal d'urologie et de nephrologie, 1968, Volume: 74, Issue:9

    Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Angioedema; Anuria; Arteritis; Arthritis; Aspirin; Dr

1968