aspirin and Pocket, Periodontal

aspirin has been researched along with Pocket, Periodontal in 15 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research

Studies (15)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Change in Gingival Index (0-3)

"Gingival Index (GI) is a measure of gingival inflammation, which is assigned a score (0-3).~Score Criteria:~0: No inflammation.~Mild inflammation, slight change in color, slight edema, no bleeding on probing.~Moderate inflammation, moderate glazing, redness, bleeding on probing.~Severe inflammation, marked redness and hypertrophy, ulceration, tendency to spontaneous bleeding." (NCT01976806)
Timeframe: Baseline and 3 months

Change in Plaque Index (0-3)

"Plaque Index (PI) is a measure of gingival inflammation as induced by bacterial plaque deposition at and under the gum line.~Score Criteria:~0: No plaque~A film of plaque adhering to the free gingival margin and adjacent area of the tooth, which can not be seen with the naked eye. But only by using disclosing solution or by using probe.~Moderate accumulation of deposits within the gingival pocket, on the gingival margin and/ or adjacent tooth surface, which can be seen with the naked eye.~Abundance of soft matter within the gingival pocket and/or on the tooth and gingival margin." (NCT01976806)
Timeframe: Baseline and 3 months

Change in Pocket Depth (mm)

Pocket probing depth (PD) is the depth a dental probe can be inserted into a gingival pocket at a particular site (6 sites per tooth) measured in millimeters among teeth with PD greater than or equal to 5 mm (N=533 dental sites total). (NCT01976806)
Timeframe: Baseline and 3 months

Change in Red Blood Cell Membrane Docosahexaenoic Acid

Red blood cell phospholipid fatty acids were measured at baseline and 3-month follow up as a measure of adherence. (NCT01976806)
Timeframe: Baseline and 3 months

Gingival Crevicular Fluid High Sensitivity C-reactive Protein

Gingival crevicular fluid (GCF) is the fluid bathing the teeth under the gum line. GCF samples were analyzed for high sensitivity C-reactive protein as a measure of local gingival inflammation. (NCT01976806)
Timeframe: Baseline and 3 months

Gingival Crevicular Fluid Interleukin-1 Beta

Gingival crevicular fluid (GCF) samples were analyzed for Interleukin-1 beta, which is a measure of local gingival inflammation. (NCT01976806)
Timeframe: Baseline and 3 months

Gingival Crevicular Fluid Interleukin-6

Gingival crevicular fluid (GCF) samples were analyzed for Interleukin-6, which is a measure of local gingival inflammation. (NCT01976806)
Timeframe: Baseline and 3 months

Serum High-sensitivity C-reactive Protein

Serum high-sensitivity C-reactive protein is a measure of systemic inflammation. (NCT01976806)
Timeframe: Baseline and 3 months

Serum High-sensitivity Interleukin-6

Serum high-sensitivity interleukin-6 is a measure of systemic inflammation. (NCT01976806)
Timeframe: Baseline and 3 months

Serum Soluble Vascular Cell Adhesion Molecule

Serum soluble vascular cell adhesion molecule (VCAM) is a measure of systemic inflammation. (NCT01976806)
Timeframe: Baseline and 3 months

Sites With Bleeding on Probing (Yes/no)

Bleeding On Probing (BOP) is a measure of gingival inflammation and tissue destruction, which describes whether or not bleeding at the dental pocket occurred following probing. (NCT01976806)
Timeframe: 3 months

Urine N-Terminal Telopeptides

Urine N-Terminal Telopeptides are a measure of systemic bone turnover. (NCT01976806)
Timeframe: Baseline and 3 months

Clinical Attachment Level at Baseline, 3 Months and 6 Months

Evaluate the difference between baseline and 6 months CAL measures. CAL: distance from bottom of sulcus/pocket to the cement-enamel junction (CEJ). The CEJ will be identified by careful probe on cervical area. (NCT03093207)
Timeframe: Baseline, 3 and 6 months

Percentage of Sites With Bleeding on Probe at Baseline, 3 Months and 6 Months

Evaluate the difference between baseline and 6 months BoP measures. BoP: bleeding that is induced by gentle probing of the sulcus/pocket. (NCT03093207)
Timeframe: Baseline, 3 and 6 months

Probing Depth at Baseline, 3 Months and 6 Months

Evaluate the difference between baseline and 6 months PB measures. PB: distance from the bottom of sulcus/pocket to gingival margin. (NCT03093207)
Timeframe: Baseline, 3 and 6 months

Change in Bleeding on Probe

Evaluate the difference between baseline and 6 months BoP measures (NCT03093246)
Timeframe: Baseline, 3 and 6 months

Change in Clinical Attachment Level

Evaluate the difference between baseline and 6 months CAL measures. (NCT03093246)
Timeframe: Baseline, 3 and 6 months

Change in Probing Depth

Evaluate the difference between baseline and 6 months PD measures. (NCT03093246)
Timeframe: Baseline, 3 and 6 months

Trials

11 trials available for aspirin and Pocket, Periodontal

Other Studies

4 other studies available for aspirin and Pocket, Periodontal