Page last updated: 2024-10-23

aspirin and Pleurisy

aspirin has been researched along with Pleurisy in 35 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Pleurisy: INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.

Research Excerpts

ExcerptRelevanceReference
" However, the role of LXA4 and aspirin (ASA)-triggered lipoxins (ATLs) in inflammatory edema formation remains unclear."7.73Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. ( Calixto, JB; Henriques, Md; Kassuya, CA; Menezes-de-Lima, O; Nascimento, AF, 2006)
"Aspirin cannot cause major haemorrhage, but in the elderly it can cause gastrointestinal bleeding via ulceration of the gastrointestinal mucosa."5.56Additive effect of dabigatran and high-dose aspirin in the development of haemorrhagic pleural effusion in a patient with tuberculous pleuritis. ( Barış, VÖ; Karagül, DA; Karnak, D, 2020)
"In carrageenin-induced pleurisy, counts of infiltrated pleural neutrophils in G-CSF-r 5 and 7 h after carrageenin were significantly higher (by 119% and 116%) than those in Vehicle-r."5.29Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. ( Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Majima, M; Ogino, M; Saito, M, 1996)
" However, the role of LXA4 and aspirin (ASA)-triggered lipoxins (ATLs) in inflammatory edema formation remains unclear."3.73Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. ( Calixto, JB; Henriques, Md; Kassuya, CA; Menezes-de-Lima, O; Nascimento, AF, 2006)
" As lipoxin A4 (LXA4) and aspirin-triggered 15-epi-LXA4 (ATL) are emerging as endogenous "stop signals" produced in distinct pathologies including some eosinophil-related pulmonary disorders, we evaluated the impact of in situ LXA4/ATL metabolically stable analogues on allergen-induced eosinophilic pleurisy in sensitized rats."3.70Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. ( Bandeira-Melo, C; Bozza, PT; Cordeiro, RS; Diaz, BL; Jose, PJ; Martins, MA; Serhan, CN, 2000)
" Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model."3.67Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives. ( Sancilio, LF; Sleevi, MC; Walsh, DA, 1984)
"Aspirin cannot cause major haemorrhage, but in the elderly it can cause gastrointestinal bleeding via ulceration of the gastrointestinal mucosa."1.56Additive effect of dabigatran and high-dose aspirin in the development of haemorrhagic pleural effusion in a patient with tuberculous pleuritis. ( Barış, VÖ; Karagül, DA; Karnak, D, 2020)
" NS-398 and nimesulide dosing did not reduce thromboxane B2 production from platelets isolated from rats with carrageenin-induced pleurisy, demonstrating that at the doses used, cyclooxygenase 2 inhibitors did not inhibit cyclooxygenase 1, as platelets contain only this isoform."1.30Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation. ( Gilroy, DW; Tomlinson, A; Willoughby, DA, 1998)
"In carrageenin-induced pleurisy, counts of infiltrated pleural neutrophils in G-CSF-r 5 and 7 h after carrageenin were significantly higher (by 119% and 116%) than those in Vehicle-r."1.29Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. ( Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Majima, M; Ogino, M; Saito, M, 1996)
"Rat pleurisy was induced by intrapleural injection of lambda-carrageenin."1.27Activation of plasma kallikrein-kinin system and its significant role in pleural fluid accumulation of rat carrageenin-induced pleurisy. ( Harada, Y; Katori, M; Tanaka, K; Uchida, Y; Ueno, A, 1983)
"The effects of protein deficiency on the biosynthesis of metabolites of arachidonic acid by rat pleural polymorphonuclear leukocytes stimulated with calcium ionophore were investigated."1.27Effects of protein deficiency on the metabolism of arachidonic acid by rat pleural polymorphonuclear leukocytes. ( Powell, WS; Varma, DR; Yue, TL, 1983)
"Phenacetin was active in the trypsin and kaolin assays with oral ED50's of 114 +/- 36."1.26Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents. ( Selph, JL; Truax, JF; Vinegar, R, 1976)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199022 (62.86)18.7374
1990's7 (20.00)18.2507
2000's4 (11.43)29.6817
2010's1 (2.86)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Walsh, DA1
Sleevi, MC1
Sancilio, LF1
Karagül, DA1
Barış, VÖ1
Karnak, D1
Savoia, F1
Gaddoni, G1
Casadio, C1
Patrizi, A1
Spadola, G1
Bassi, P1
Albertini, F1
Ballardini, G1
Briganti, E1
Casolari, S1
De Donà, D1
Menni, B1
Zanotti, M1
De Angelis, P1
Menezes-de-Lima, O1
Kassuya, CA1
Nascimento, AF1
Henriques, Md1
Calixto, JB1
Fujino, N1
Uchida, Y2
Tanaka, K4
Harada, Y7
Ueno, A2
Katori, M6
Yue, TL1
Varma, DR1
Powell, WS1
Yamashita, K2
Ishibashi, M3
Miyazaki, H3
Vinegar, R3
Truax, JF3
Selph, JL3
Voelker, FA1
Oh-Ishi, S1
Saldi, M1
Yamashita, Y1
Hatanaka, K3
Majima, M2
Kawamura, M3
Ohno, T2
Aizawa, A1
Yamamoto, S1
Ogino, M2
Saito, M2
Bandeira-Melo, C2
Singh, Y1
Cordeiro, RS2
e Silva, PM1
Martins, MA2
Ogino, K1
Yang, Q1
Gilroy, DW1
Tomlinson, A1
Willoughby, DA2
Bozza, PT1
Diaz, BL1
Jose, PJ1
Serhan, CN1
Louerat, C1
Hominal, S1
Perol, M1
Nesme, P1
Guerin, JC1
Meacock, SC1
Kitchen, EA1
Rothkopf, M1
Vogel, G1
Roch-Arveiller, M2
Revelant, V1
Pham Huy, D1
Maman, L2
Fontagne, J1
Sorenson, JR2
Giroud, JP2
Huy, DP1
Paegelow, I1
Werner, H1
Chiabrando, C1
Castelli, MG1
Cozzi, E1
Fanelli, R1
Campoleoni, A1
Balotta, C1
Latini, R1
Garattini, S1
Di Rosa, M2
Sorrentino, L1
Parente, L1
Wright, MG1
Utting, JA1
Shreeve, DR1
Panush, RS1
Franco, AE1
Schur, PH1
Buckler, RT1
Papadimitriou, JM1
Vailati, G1
Montini, M1
Bonicelli, A1
Pagani, G1
Kok-Jensen, A1
Lindeneg, O1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755]62 participants (Actual)Interventional2017-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for aspirin and Pleurisy

ArticleYear
[Postmyocardial infarction syndrome].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Sep-28, Volume: Suppl 5 Pt 2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diagnosis, Differential; Diagnostic Imaging; Endoc

2007

Other Studies

34 other studies available for aspirin and Pleurisy

ArticleYear
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Chemical Phenomena; Chemistry

1984
Additive effect of dabigatran and high-dose aspirin in the development of haemorrhagic pleural effusion in a patient with tuberculous pleuritis.
    Malawi medical journal : the journal of Medical Association of Malawi, 2020, Volume: 32, Issue:3

    Topics: Aged; Antithrombins; Antitubercular Agents; Aspirin; Dabigatran; Humans; Male; Pleural Effusion; Ple

2020
A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.
    Dermatology online journal, 2010, Feb-15, Volume: 16, Issue:2

    Topics: Anti-Inflammatory Agents; Aspirin; Chronic Disease; Colchicine; Dermatologic Agents; Drug Therapy, C

2010
Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin.
    Prostaglandins & other lipid mediators, 2006, Volume: 80, Issue:3-4

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bradykinin; Carrageenan; D

2006
Activation of plasma kallikrein-kinin system and its significant role in pleural fluid accumulation of rat carrageenin-induced pleurisy.
    Inflammation, 1983, Volume: 7, Issue:2

    Topics: Animals; Aspirin; Bromelains; Captopril; Carrageenan; Kininogens; Kinins; Male; Molecular Weight; Pl

1983
Effects of protein deficiency on the metabolism of arachidonic acid by rat pleural polymorphonuclear leukocytes.
    Biochimica et biophysica acta, 1983, May-16, Volume: 751, Issue:3

    Topics: Animals; Arachidonic Acids; Aspirin; Carrageenan; Disease Models, Animal; Kidney Medulla; Lipoxygena

1983
The anti-inflammatory mechanism of MK-447 in rat carrageenin-induced pleurisy.
    Prostaglandins, 1983, Volume: 26, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Butylated Hydroxytoluene; Carrageenan; Gas Chromatograph

1983
Pathway of onset, development, and decay of carrageenan pleurisy in the rat.
    Federation proceedings, 1982, Volume: 41, Issue:9

    Topics: Animals; Aspirin; Carrageenan; Colchicine; Cyclooxygenase Inhibitors; Exudates and Transudates; Mono

1982
Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry.
    Prostaglandins, 1982, Volume: 23, Issue:6

    Topics: Animals; Aspirin; Carrageenan; Gas Chromatography-Mass Spectrometry; Imidazoles; Male; Pleurisy; Pro

1982
[Broncaspin in the therapy of pediatric diseases of the respiratory tract].
    Minerva medica, 1981, Feb-28, Volume: 72, Issue:7

    Topics: Age Factors; Anti-Bacterial Agents; Aspirin; Bronchitis; Bronchopneumonia; Child; Child, Preschool;

1981
Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy.
    Advances in prostaglandin and thromboxane research, 1980, Volume: 8

    Topics: Animals; Aspirin; Butylated Hydroxytoluene; Carrageenan; Disease Models, Animal; Imidazoles; Inflamm

1980
Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of a selective COX-2 inhibitor.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Animals; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Dexamethasone; Enzyme Induction; Isoenzyme

1995
Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:7

    Topics: Animals; Aspirin; Bradykinin; Capillary Permeability; Carrageenan; Cell Movement; Complement System

1996
Involvement of prostaglandins in the down-regulation of allergic plasma leakage observed in rats undergoing pleural eosinophilia.
    British journal of pharmacology, 1996, Volume: 118, Issue:8

    Topics: Animals; Aspirin; Dinoprostone; Down-Regulation; Eosinophils; Female; Hypersensitivity; Indomethacin

1996
Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat.
    Prostaglandins & other lipid mediators, 1998, Volume: 55, Issue:5-6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygen

1998
Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation.
    European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo

1998
Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Mar-01, Volume: 164, Issue:5

    Topics: Allergens; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Mig

2000
[Post-cardiac aggression syndrome: a case report].
    Revue de pneumologie clinique, 2000, Volume: 56, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diagnosis, Differential; Female; Follow-Up

2000
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
    Agents and actions, 1976, Volume: 6, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen

1976
[New findings on the efficacy and mode of action of the horse chestnut saponin escin].
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:2

    Topics: Animals; Aspirin; Bradykinin; Dose-Response Relationship, Drug; Escin; Exudates and Transudates; Fem

1976
Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents.
    European journal of pharmacology, 1976, Volume: 37, Issue:1

    Topics: Acetaminophen; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carragee

1976
Effects of some non-steroidal anti-inflammatory drug copper complexes on polymorphonuclear leukocyte oxidative metabolism.
    Agents and actions, 1990, Volume: 31, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Copper; Free Radical Scavengers; In Vitro

1990
Non-steroidal anti-inflammatory drug-copper complex modulation of polymorphonuclear leukocyte migration.
    Biochemical pharmacology, 1990, Feb-01, Volume: 39, Issue:3

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Movement; Che

1990
Modulation of the IL-1 content by anti-inflammatory drugs during an acute non-specific inflammation.
    Agents and actions, 1989, Volume: 26, Issue:1-2

    Topics: Animals; Aspirin; Calcium Pyrophosphate; Dexamethasone; Diclofenac; Interleukin-1; Male; Mice; Mice,

1989
Antiinflammatory action of salicylates: aspirin is not a prodrug for salicylate against rat carrageenin pleurisy.
    European journal of pharmacology, 1989, Jan-17, Volume: 159, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Cell Count; Carrageenan; Gas Chroma

1989
Non-steroidal anti-inflammatory drugs and leucocyte emigration.
    The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cell Movement; Dextrans; Flufenamic Acid; Indomethacin;

1972
Rheumatoid laryngitis.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:11

    Topics: Aged; Aspirin; Humans; Hypothyroidism; Iodine Radioisotopes; Laryngitis; Male; Pleurisy; Prednisolon

1973
Haemolytic-uraemic syndrome in an adult with pericarditis and pleurisy.
    British medical journal, 1973, Jun-09, Volume: 2, Issue:5866

    Topics: Adult; Alopecia; Anemia, Hemolytic; Aspirin; Dipyridamole; Female; Hemolytic-Uremic Syndrome; Hepari

1973
Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 143, Issue:3

    Topics: Animals; Aspirin; Carrageenan; Cyproheptadine; Edema; Exudates and Transudates; Injections; Leukocyt

1973
Rheumatoid arthritis associated with eosinophilia.
    Annals of internal medicine, 1971, Volume: 75, Issue:2

    Topics: Aged; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Aspirin; Complement System Proteins; Eosino

1971
Structure-activity relationships among some antiinflammatory 3-(5-aryl-2-tetrazolyl)alkanoic acids and derivatives.
    Journal of medicinal chemistry, 1972, Volume: 15, Issue:6

    Topics: Acetates; Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Aspirin; Azoles; Carragee

1972
A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs.
    The Journal of pathology, 1971, Volume: 105, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Carrageenan; Edema; Indomethacin; Leukocyte

1971
[Clinical-experimental study of lysine acetylsalicylate].
    Giornale di clinica medica, 1971, Volume: 52, Issue:10

    Topics: Adolescent; Adult; Aged; Aspirin; Blood Coagulation; Bone Neoplasms; Female; Fever; Fractures, Bone;

1971
Pleurisy and fibrosis of the pleura during methysergide treatment of hemicrania.
    Scandinavian journal of respiratory diseases, 1970, Volume: 51, Issue:3

    Topics: Adult; Aspirin; Codeine; Diazepam; Ergotamine; Female; Functional Laterality; Humans; Male; Methyser

1970