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aspirin and Peptic Ulcer Perforation

aspirin has been researched along with Peptic Ulcer Perforation in 30 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Peptic Ulcer Perforation: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the incidence and mortality related to peptic ulcer perforation while considering the intake of low-dose aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)."7.74Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs. ( Angerson, WJ; Gilmour, D; McCloskey, C; Morran, CG; Prasad, R; Taha, AS, 2008)
"Current studies lack appropriate data on aspirin and other risk factors for gastrointestinal perforation."7.69Evidence of aspirin use in both upper and lower gastrointestinal perforation. ( Bajador, E; Benito, R; Esteva, F; Lanas, A; Sáinz, R; Serrano, P, 1997)
"To evaluate the incidence and mortality related to peptic ulcer perforation while considering the intake of low-dose aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)."3.74Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs. ( Angerson, WJ; Gilmour, D; McCloskey, C; Morran, CG; Prasad, R; Taha, AS, 2008)
"Current studies lack appropriate data on aspirin and other risk factors for gastrointestinal perforation."3.69Evidence of aspirin use in both upper and lower gastrointestinal perforation. ( Bajador, E; Benito, R; Esteva, F; Lanas, A; Sáinz, R; Serrano, P, 1997)
"The gastric ulcer is easily detected by a barium meal study although a barium enema may be necessary to show the fistulous communication."1.26Gastrocolic fistula as a complication of benign gastric ulcer. ( Laufer, I; Stolberg, H; Thornley, GD, 1976)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199023 (76.67)18.7374
1990's1 (3.33)18.2507
2000's6 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Taha, AS1
Angerson, WJ1
Prasad, R1
McCloskey, C1
Gilmour, D1
Morran, CG1
Hermansson, M1
Ekedahl, A1
Ranstam, J1
Zilling, T1
Reed, S1
PLEWINSKI, G1
WANKA, J1
JONES, LI1
WOOD, PH1
DIXON, AS1
Lanas, A2
García Rodríguez, LA1
Barreales Tolosa, L1
Berndt, H1
Serrano, P1
Bajador, E1
Esteva, F1
Benito, R1
Sáinz, R1
Jost, JL1
Vayre, P1
Hureau, J1
Benit, C1
Takeuchi, K1
Okabe, S1
Takagi, K1
Umeda, N1
Barkin, JS1
Langman, MJ2
Tysiachnova, OV1
Brown, RC1
Lambert, PM1
Laufer, I1
Thornley, GD1
Stolberg, H1
Hazleman, BL1
Florent, C1
Desaint, B1
Henry, DA1
Johnston, A1
Dobson, A1
Duggan, J1
Kolbasa, KP1
Lancaster, C1
Olafsson, AS1
Gilbertson, SK1
Robert, A1
Matthewson, K1
Pugh, S1
Northfield, TC1
Christensen, LA1
Schmidt, EB1
Levrat, M1
Bock, OA1
Grabowski, T1
Duggan, JM2
Hugh, TB1
Donnellan, M1
Fagan, PA1

Reviews

3 reviews available for aspirin and Peptic Ulcer Perforation

ArticleYear
Gastrointestinal injury from NSAID therapy. How to reduce the risk of complications.
    Postgraduate medicine, 2005, Volume: 117, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Dyspepsia; Gastrointest

2005
Incidence of gastropathy in destructive arthropathies.
    Scandinavian journal of rheumatology. Supplement, 1989, Volume: 78

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Esophagus; Female; Gastrointestinal H

1989
[Modern views on peptic ulcers].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1970, Nov-01, Volume: 23, Issue:21

    Topics: Alcohols; Aspirin; Duodenal Ulcer; Female; Gastric Mucosa; Gastrins; Humans; Male; Parasympatholytic

1970

Other Studies

27 other studies available for aspirin and Peptic Ulcer Perforation

ArticleYear
Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs.
    Alimentary pharmacology & therapeutics, 2008, Oct-01, Volume: 28, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Comorbidity;

2008
Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974-2002.
    BMC gastroenterology, 2009, Apr-20, Volume: 9

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Dose-Response Relationshi

2009
Nonsteroidal anti-inflammatory drug-induced duodenal ulceration and perforation in a mature rottweiler.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2002, Volume: 43, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dog Diseases; Dogs; Duodenal Ulcer; Male;

2002
[PERFORATED GASTRIC ULCER AS A COMPLICATION OF ACTH AND ASPIRIN THERAPY].
    Polski przeglad chirurgiczny, 1963, Volume: 35

    Topics: Adrenocorticotropic Hormone; Aspirin; Humans; Optic Neuritis; Peptic Ulcer Perforation; Stomach Ulce

1963
INDOMETHACIN IN RHEUMATIC DISEASES. A CONTROLLED CLINICAL TRIAL.
    Annals of the rheumatic diseases, 1964, Volume: 23

    Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Biomedical Research; Drug Hypersensitivity; Gastrointesti

1964
Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population.
    Gastroenterology, 2007, Volume: 132, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Case-Control St

2007
[Pathogen eradication prevents gastrointestinal complications].
    MMW Fortschritte der Medizin, 2007, Oct-25, Volume: 149, Issue:43

    Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspi

2007
[Drug-induced hemorrhages of the gastrointestinal tract].
    Zeitschrift fur arztliche Fortbildung, 1983, Volume: 77, Issue:12

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Ethacrynic Acid; Gastrit

1983
Evidence of aspirin use in both upper and lower gastrointestinal perforation.
    Gastroenterology, 1997, Volume: 112, Issue:3

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Helicobacter Infections; Helicobacte

1997
[Massive pneumoperitoneum as a sequela to rupture of a gastric ulcer and ventilatory resuscitation under pressure].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1978, Jan-16, Volume: 54, Issue:3

    Topics: Aspirin; Drowning; Female; Humans; Middle Aged; Oxygen Inhalation Therapy; Peptic Ulcer Perforation;

1978
Influence of aspirin on healing of chronic gastric ulcers in dogs.
    Digestion, 1977, Volume: 16, Issue:1-2

    Topics: Acetates; Animals; Aspirin; Chronic Disease; Dogs; Gastric Mucosa; Gastroscopy; Male; Peptic Ulcer P

1977
Intractable peptic ulcer disease.
    Comprehensive therapy, 1976, Volume: 2, Issue:6

    Topics: Aspirin; Chronic Disease; Humans; Hypercalcemia; Hyperparathyroidism; Peptic Ulcer; Peptic Ulcer Per

1976
Gastric ulcer: natural history and treatment.
    Australian and New Zealand journal of medicine, 1976, Volume: 6 Suppl 1

    Topics: Adult; Aspirin; Australia; Boston; Carbenoxolone; Female; Gastrointestinal Hemorrhage; Glycyrrhiza;

1976
[Case of multiple performation of intestinal ulcers during treatment with prednisolone, aspirin and potassium chloride ].
    Klinicheskaia meditsina, 1975, Volume: 53, Issue:9

    Topics: Adolescent; Aspirin; Humans; Ileum; Male; Peptic Ulcer; Peptic Ulcer Perforation; Potassium Chloride

1975
Hospital admissions for peptic ulcer during 1958-72.
    British medical journal, 1976, Jan-03, Volume: 1, Issue:6000

    Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Female; Hospitalization; Humans; Male; Middle Aged; P

1976
Gastrocolic fistula as a complication of benign gastric ulcer.
    Radiology, 1976, Volume: 119, Issue:1

    Topics: Adult; Aged; Aspirin; Barium Sulfate; Colonic Diseases; Colonic Neoplasms; Diagnosis, Differential;

1976
[Frequency and severity of gastric and duodenal lesions induced by non-steroidal anti-inflammatory agents and aspirin].
    Gastroenterologie clinique et biologique, 1989, Volume: 13, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; France; Humans; Male; Peptic Ulcer; Peptic

1989
Ulcer perforation in the elderly and non-steroidal anti-inflammatory drugs.
    Lancet (London, England), 1986, Apr-26, Volume: 1, Issue:8487

    Topics: Aged; Anti-Inflammatory Agents; Aspirin; Humans; Middle Aged; Peptic Ulcer; Peptic Ulcer Perforation

1986
Fatal peptic ulcer complications and the use of non-steroidal anti-inflammatory drugs, aspirin, and corticosteroids.
    British medical journal (Clinical research ed.), 1987, Nov-14, Volume: 295, Issue:6608

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

1987
Indomethacin-induced gastric antral ulcers in hamsters.
    Gastroenterology, 1988, Volume: 95, Issue:4

    Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal

1988
Which peptic ulcer patients bleed?
    Gut, 1988, Volume: 29, Issue:1

    Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Male; Mi

1988
Perforated peptic ulcer--a complication in acute salicylate intoxication.
    Acta medica Scandinavica, 1987, Volume: 222, Issue:2

    Topics: Acute Disease; Acute Kidney Injury; Aspirin; Cimetidine; Female; Humans; Middle Aged; Peptic Ulcer P

1987
[Nosologic borderlines of gastroduodenal ulcerous disease].
    Archives francaises des maladies de l'appareil digestif, 1972, Volume: 61, Issue:3

    Topics: Aspirin; Diagnosis, Differential; Gastritis; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Pept

1972
The management of a patient with a duodenal ulcer.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Nov-25, Volume: 46, Issue:47

    Topics: Adult; Alcohol Drinking; Alkalies; Aspirin; Chronic Disease; Diet Therapy; Duodenal Ulcer; Humans; P

1972
Aspirin ingestion and perforated peptic ulcer.
    Gut, 1972, Volume: 13, Issue:8

    Topics: Aspirin; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer Perforation; Sex Factors; Stomach Ulcer;

1972
Perforated peptic ulcer.
    The Medical journal of Australia, 1969, Oct-25, Volume: 2, Issue:17

    Topics: Adult; Age Factors; Aspirin; Australia; Duodenal Ulcer; Female; Follow-Up Studies; Gastrectomy; Huma

1969
The relationship between perforated peptic ulcer and aspirin ingestion.
    The Medical journal of Australia, 1965, Oct-16, Volume: 2, Issue:16

    Topics: Aged; Aspirin; Duodenal Ulcer; Dyspepsia; Female; Humans; Male; Middle Aged; Peptic Ulcer Perforatio

1965