Page last updated: 2024-10-23

aspirin and Patency of the Ductus Arteriosus

aspirin has been researched along with Patency of the Ductus Arteriosus in 26 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
" In patients with patent foramen ovale (PFO) and stroke or transient ischemic attack, we recommend initial aspirin therapy (Grade 1B) and suggest substitution of VKA if recurrence (Grade 2C)."3.78Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. ( Fremes, SE; Rubens, FD; Sun, JC; Teoh, KH; Whitlock, RP, 2012)
" Observations collected in two population pharmacokinetic studies, in preterm neonates, investigating amikacin and vancomycin were used to estimate: i) the impact of ibuprofen administration on the clearance of these drugs; and ii) the difference between prophylactic and therapeutic administration of ibuprofen on this clearance."2.72Impact of ibuprofen administration on renal drug clearance in the first weeks of life. ( Allegaert, K; Anderson, BJ; Rayyan, M, 2006)
"Aspirin (ASA) is an alternative, but there are no controlled trials on its efficacy."2.68Aspirin versus indomethacin treatment of patent ductus arteriosus in preterm infants with respiratory distress syndrome. ( Brus, F; Elzenga, NJ; Okken, A; Schasfoort, M; van Acker, KJ; van der Auwera, JC; van Overmeire, B, 1995)
"Aspirin treatment during pregnancy seemed to reduce the incidence of hs-PDA in preterm infant and to increase infant responsiveness to postnatal medical treatment of PDA."1.72Effects of maternal aspirin treatment on hemodynamically significant patent ductus arteriosus in preterm infants - pilot study. ( Beer, G; Fridman, E; Kapusta, L; Mandel, D; Mangel, L; Marom, R, 2022)
"Here is a case of a female with patent ductus arteriosus, who was apparently in quite good state of health and gave birth to six offsprings without herself having any problem."1.48Patent Ductus Arteriosus with Infective Vegetations in Grandmultipara. ( Siddiqa, A; Sohail, N, 2018)
"Indomethacin is used to close the patent ductus arteriosus in premature infants and for tocolysis of preterm labor."1.35Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat. ( Imamura, S; Ito, K; Momma, K; Nakanishi, T; Sugiyama, K; Sun, F; Toyoshima, K, 2009)
" Patients with this renal disorder require a permanent high dosed indomethacin therapy."1.27[The significance of renal prostaglandins for kidney function in early childhood]. ( Seyberth, HW, 1987)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199019 (73.08)18.7374
1990's1 (3.85)18.2507
2000's2 (7.69)29.6817
2010's3 (11.54)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Fridman, E1
Mangel, L1
Mandel, D1
Beer, G1
Kapusta, L1
Marom, R1
Siddiqa, A1
Sohail, N1
Kimura, M1
Kanazawa, H1
Kawamura, A1
Yamamoto, T1
Egashira, T1
Kohno, T1
Maekawa, Y1
Sano, M1
Fukuda, K1
Momma, K1
Toyoshima, K1
Ito, K1
Sugiyama, K1
Imamura, S1
Sun, F1
Nakanishi, T1
Whitlock, RP1
Sun, JC1
Fremes, SE1
Rubens, FD1
Teoh, KH1
Allegaert, K1
Rayyan, M1
Anderson, BJ1
Furst, DE1
Niebyl, JR2
Friedberg, DZ1
Rajpal, RS1
Litwin, SB1
Zondlo, J1
van Overmeire, B1
Brus, F1
van Acker, KJ1
van der Auwera, JC1
Schasfoort, M1
Elzenga, NJ1
Okken, A1
Bartel, J1
Dipalma, JR1
Horwitz, DL1
Rudolph, AM2
Heymann, MA3
Schrager, GO1
Soós, J1
Várkonyi, P1
Hartyánszky, I1
Szabolcs, J1
Fekete-Farkas, P1
Lozsádi, K1
Hoffman, JI1
Sharpe, GL1
Altshuler, G1
Lines, DR1
Cooperman, EM1
Silverman, NH1
Sibai, BM1
Mirro, R1
Chesney, CM1
Leffler, C1
Witter, FR1
Anker, R1
Quezada, A1
Seyberth, HW1
Cunningham, MD1
Ellison, RC1
Zierler, S1
Kanto, WP1
Miettinen, OS1
Nadas, AS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]Phase 344 participants (Anticipated)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for aspirin and Patency of the Ductus Arteriosus

ArticleYear
Preterm parturition. Prostaglandin synthetase inhibitors.
    Seminars in perinatology, 1981, Volume: 5, Issue:3

    Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P

1981
[Drug therapy of patent ductus arteriosus in premature and newborn infants].
    Kinderarztliche Praxis, 1978, Volume: 46, Issue:12

    Topics: Apnea; Aspirin; Chloroquine; Digitalis Glycosides; Ductus Arteriosus, Patent; Humans; Indomethacin;

1978
[Derivatives of arachidonic acid. II. Medical perspectives].
    Boletin medico del Hospital Infantil de Mexico, 1986, Volume: 43, Issue:5

    Topics: Aspirin; Dinoprostone; Ductus Arteriosus, Patent; Humans; Immunity, Cellular; Indomethacin; Leukocyt

1986

Trials

4 trials available for aspirin and Patency of the Ductus Arteriosus

ArticleYear
Impact of ibuprofen administration on renal drug clearance in the first weeks of life.
    Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:8

    Topics: Age Factors; Amikacin; Anti-Bacterial Agents; Aspirin; Betamethasone; Birth Weight; Cyclooxygenase I

2006
Aspirin versus indomethacin treatment of patent ductus arteriosus in preterm infants with respiratory distress syndrome.
    Pediatric research, 1995, Volume: 38, Issue:6

    Topics: Aspirin; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Logistic Models; Prospect

1995
Low-dose aspirin in pregnancy.
    Obstetrics and gynecology, 1989, Volume: 74, Issue:4

    Topics: Alprostadil; Apgar Score; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Ductus Arterio

1989
Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects.
    Seminars in perinatology, 1986, Volume: 10, Issue:4

    Topics: Administration, Oral; Arachidonic Acid; Arachidonic Acids; Aspirin; Clinical Trials as Topic; Cycloo

1986

Other Studies

19 other studies available for aspirin and Patency of the Ductus Arteriosus

ArticleYear
Effects of maternal aspirin treatment on hemodynamically significant patent ductus arteriosus in preterm infants - pilot study.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:5

    Topics: Aspirin; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant, Newborn; Infant, Premature; P

2022
Patent Ductus Arteriosus with Infective Vegetations in Grandmultipara.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:9

    Topics: Adult; Aspirin; Ductus Arteriosus, Patent; Echocardiography; Endocarditis, Bacterial; Female; Fever;

2018
Simultaneous transcatheter closure of an atrial septal defect and patent ductus arteriosus in an adult case, followed by thrombocytopenia and subclinical hemolysis.
    International journal of cardiology, 2016, Mar-15, Volume: 207

    Topics: Aged; Aspirin; Cardiac Catheterization; Ductus Arteriosus, Patent; Female; Heart Septal Defects, Atr

2016
Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat.
    Neonatology, 2009, Volume: 96, Issue:2

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibito

2009
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
    Chest, 2012, Volume: 141, Issue:2 Suppl

    Topics: Aspirin; Catheterization; Combined Modality Therapy; Ductus Arteriosus, Patent; Evidence-Based Medic

2012
Use of ibuprofen in unusual circumstances.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Arthritis, Rheumatoid; Aspirin; Bartter Syndrome; Cyclooxygenase Inhibitors; Digoxin; Drug Hypersens

1984
Persistent reactivity of patent ductus with a review of the mechanism of spontaneous closure.
    American journal of diseases of children (1960), 1981, Volume: 135, Issue:5

    Topics: Aspirin; Cardiac Catheterization; Child, Preschool; Ductus Arteriosus, Patent; Female; Heart Murmurs

1981
Pharmacology of the ductus arteriosus.
    American family physician, 1978, Volume: 17, Issue:1

    Topics: Aspirin; Chloroquine; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, Patent; Femal

1978
Aspirin: new uses for an old drug.
    Comprehensive therapy, 1979, Volume: 5, Issue:10

    Topics: Aspirin; Bartter Syndrome; Diabetic Angiopathies; Ductus Arteriosus, Patent; Humans; Myocardial Infa

1979
Medical treatment of the ductus arteriosus.
    Hospital practice, 1977, Volume: 12, Issue:2

    Topics: Animals; Aspirin; Coronary Circulation; Ductus Arteriosus; Ductus Arteriosus, Patent; Fetal Heart; F

1977
PDAs, prostaglandins, and RLF.
    Pediatrics, 1978, Volume: 62, Issue:5

    Topics: Aspirin; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Pregnancy; Prosta

1978
[Possibility of closure of the patent dutus arteriosus by drug therapy in the management of congenital defects in the newborn infant (preliminary report)].
    Orvosi hetilap, 1978, Sep-17, Volume: 119, Issue:38

    Topics: Aspirin; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male

1978
Problem of patent ductus arteriosus in premature infants.
    Paediatrician, 1978, Volume: 7, Issue:1-3

    Topics: Animals; Aspirin; Blood Pressure; Coronary Circulation; Ductus Arteriosus, Patent; Heart Failure; He

1978
Ductal manipulation--a note of caution.
    The Journal of pediatrics, 1977, Volume: 90, Issue:2

    Topics: Aspirin; Ductus Arteriosus; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Oxygen

1977
Breakthrough in treatment of patent ductus arteriosus.
    Drugs, 1977, Volume: 13, Issue:1

    Topics: Aspirin; Chloroquine; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Prem

1977
New uses for acetylsalicylic acid and other prostaglandin antagonists.
    Canadian Medical Association journal, 1977, Aug-20, Volume: 117, Issue:4

    Topics: Aspirin; Crohn Disease; Ductus Arteriosus; Ductus Arteriosus, Patent; Female; Humans; Infant, Newbor

1977
Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis.
    The New England journal of medicine, 1976, Sep-02, Volume: 295, Issue:10

    Topics: Aspirin; Depression, Chemical; Ductus Arteriosus; Ductus Arteriosus, Patent; Female; Follow-Up Studi

1976
[The significance of renal prostaglandins for kidney function in early childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1987, Volume: 135, Issue:4

    Topics: Angiotensin II; Aspirin; Child, Preschool; Creatinine; Ductus Arteriosus, Patent; Glomerular Filtrat

1987
Perinatal risk assessment for patent ductus arteriosus in premature infants.
    Obstetrics and gynecology, 1986, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aspirin; Birth Weight; Ductus Arteriosus, Patent; Female; Histamine Antagonists;

1986