aspirin has been researched along with Osteoporosis in 30 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the present study was to assess the effectiveness of combined salmon calcitonin (sCT) and aspirin [acetylsalicylic acid (ASA)] treatment in an ovariectomized (OVX) rat model of postmenopausal osteoporosis." | 7.81 | Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats. ( Gong, Y; Wang, J; Wei, J; Zeng, R, 2015) |
| "To explore the therapeutic effects of aspirin on postmenopausal osteoporosis and understand its action mechanism." | 7.77 | [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. ( Chen, ZW; Feng, J; Li, XJ; Qin, GL; Sang, HX; Wang, J; Wang, JC; Wang, LS; Wu, ZX; Zhang, D, 2011) |
| " Gastric ulcers developed in five out of 26 subjects given ASA, two out of 25 given alendronate, and none of 25 given placebo." | 5.09 | A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract. ( Hunt, RH; James, C; Marshall, JK; Rainsford, KD, 2000) |
| "Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted." | 4.31 | NHANES cross sectional study of aspirin and fractures in the elderly. ( Abbas, KS; Abouainain, Y; Ahmad, EMS; Albuni, MK; Battikh, E; El-Sakka, AA; Elkalagi, NKH; Hafez, W; Lee, KY; Rakab, A; Sawaf, B; Swed, S, 2023) |
| "The objective of the present study was to assess the effectiveness of combined salmon calcitonin (sCT) and aspirin [acetylsalicylic acid (ASA)] treatment in an ovariectomized (OVX) rat model of postmenopausal osteoporosis." | 3.81 | Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats. ( Gong, Y; Wang, J; Wei, J; Zeng, R, 2015) |
| "Patients receiving alendronate for osteoporosis carry a significantly higher risk of developing upper gastrointestinal bleeding (GIB) and lower GIB (hazard ratio 1." | 3.80 | Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study. ( Hou, MC; Hu, HY; Lee, FY; Lin, HC; Luo, JC; Peng, YL, 2014) |
| "To explore the therapeutic effects of aspirin on postmenopausal osteoporosis and understand its action mechanism." | 3.77 | [Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model]. ( Chen, ZW; Feng, J; Li, XJ; Qin, GL; Sang, HX; Wang, J; Wang, JC; Wang, LS; Wu, ZX; Zhang, D, 2011) |
| "Our findings have revealed a novel osteoporosis mechanism in which activated T cells induce BMMSC apoptosis via Fas/Fas ligand pathway and suggested that pharmacologic stem cell based intervention by aspirin may be a new alternative in osteoporosis treatment including activated osteoblasts and inhibited osteoclasts." | 3.74 | Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. ( Akiyama, K; Bi, Y; Chen, W; Gronthos, S; Gutkind, S; Le, A; Liu, Y; Miura, Y; Patel, V; Shi, S; Sonoyama, W; Wang, CY; Yamaza, T; Young, M, 2008) |
| " The medications were pravastatin, a cholesterol-lowering drug for the prevention of cardiovascular disease; alendronate, a bisphosphonate for the treatment and prevention of osteoporosis; and aspirin, which is used for the prevention of cardiovascular disease." | 3.70 | Coverage by the news media of the benefits and risks of medications. ( Bero, L; Henry, D; Lee, K; Mah, C; Moynihan, R; Ross-Degnan, D; Soumerai, SB; Watkins, J, 2000) |
| "The effect of acetylsalicylic acid (aspirin) on bone mass and bone prostaglandin E (PGE) in immobilization osteoporosis was studied in 12 growing dogs using a unilateral hind limb cast-fixation model." | 3.68 | Immobilization increases bone prostaglandin E. Effect of acetylsalicylic acid on disuse osteoporosis studied in dogs. ( Caywood, DD; Hodgson, SF; Trachte, GJ; Turner, RT; Waters, DJ, 1991) |
| " In order to achieve the desired results and, as with all medications, PPIs should always be used appropriately taking care never to exceed correct dosage and duration." | 2.47 | Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections. ( Ferraccioli, GF; Gremese, E; Laria, A; Zoli, A, 2011) |
| " Long-term use of heparin in pregnancy may cause significant osteoporosis, which appears to be reversible." | 2.38 | Drug therapy during pregnancy. ( Niebyl, JR, 1991) |
| "Aspirin is a commonly used antipyretic, analgesic, and anti-inflammatory drug." | 1.91 | Aspirin prevents estrogen deficiency-induced bone loss by inhibiting osteoclastogenesis and promoting osteogenesis. ( Chang, Y; Hu, Y; Kong, K; Li, H; Qiao, H; Tong, Z; Xia, R; Zhai, Z; Zhang, J, 2023) |
| "This behavior recommends that treatment of osteoporosis via calcitonin does not provide the required upshots." | 1.56 | Biophysics and the nonlinear dynamics instigated by a special hormone. ( Asif, A; Javed, S; Nutini, A; Sohail, A, 2020) |
| "Aspirin treatment significantly prevented bone loss by increasing bone formation." | 1.43 | Aspirin prevents bone loss with little mechanical improvement in high-fat-fed ovariectomized rats. ( Cui, L; Fu, Z; Huang, J; Huang, M; Lee, WYW; Li, G; Liang, Y; Lin, S; Suen, CW; Wu, H; Wu, T; Xu, L, 2016) |
| "Osteoporosis is a syndrome of excessive skeletal fragility characterized by the loss of mass and deterioration of microarchitecture in bone." | 1.42 | Co-administration of aspirin and allogeneic adipose-derived stromal cells attenuates bone loss in ovariectomized rats through the anti-inflammatory and chemotactic abilities of aspirin. ( Li, W; Liu, H; Liu, Y; Zhang, X; Zhou, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 11 (36.67) | 24.3611 |
| 2020's | 5 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hussain, SM | 1 |
| Ebeling, PR | 1 |
| Barker, AL | 1 |
| Beilin, LJ | 1 |
| Tonkin, AM | 1 |
| McNeil, JJ | 1 |
| Swed, S | 1 |
| El-Sakka, AA | 1 |
| Abouainain, Y | 1 |
| Lee, KY | 1 |
| Sawaf, B | 1 |
| Albuni, MK | 1 |
| Battikh, E | 1 |
| Ahmad, EMS | 1 |
| Elkalagi, NKH | 1 |
| Abbas, KS | 1 |
| Hafez, W | 1 |
| Rakab, A | 1 |
| Chang, Y | 1 |
| Kong, K | 1 |
| Tong, Z | 1 |
| Qiao, H | 1 |
| Hu, Y | 1 |
| Xia, R | 1 |
| Zhang, J | 1 |
| Zhai, Z | 1 |
| Li, H | 1 |
| Chavatza, K | 1 |
| Kostopoulou, M | 1 |
| Nikolopoulos, D | 1 |
| Gioti, O | 1 |
| Togia, K | 1 |
| Andreoli, L | 1 |
| Aringer, M | 1 |
| Boletis, J | 1 |
| Doria, A | 1 |
| Houssiau, FA | 1 |
| Jayne, D | 1 |
| Mosca, M | 1 |
| Svenungsson, E | 1 |
| Tincani, A | 1 |
| Bertsias, G | 1 |
| Fanouriakis, A | 1 |
| Boumpas, DT | 1 |
| Yang, Q | 1 |
| Li, FL | 1 |
| Chai, SC | 1 |
| Foley, EM | 1 |
| Arjmandi, BH | 1 |
| Tao, ZS | 1 |
| Wu, XJ | 2 |
| Zhou, WS | 1 |
| Liao, W | 1 |
| Yang, M | 1 |
| Xu, HG | 1 |
| Yang, L | 1 |
| Javed, S | 1 |
| Sohail, A | 1 |
| Asif, A | 1 |
| Nutini, A | 1 |
| Peng, YL | 1 |
| Hu, HY | 1 |
| Luo, JC | 1 |
| Hou, MC | 1 |
| Lin, HC | 1 |
| Lee, FY | 1 |
| Wei, J | 1 |
| Wang, J | 2 |
| Gong, Y | 1 |
| Zeng, R | 1 |
| Liu, H | 1 |
| Li, W | 1 |
| Liu, Y | 2 |
| Zhang, X | 1 |
| Zhou, Y | 1 |
| Lin, S | 1 |
| Lee, WYW | 1 |
| Huang, M | 1 |
| Fu, Z | 1 |
| Liang, Y | 1 |
| Wu, H | 1 |
| Xu, L | 1 |
| Suen, CW | 1 |
| Huang, J | 1 |
| Wu, T | 1 |
| Cui, L | 1 |
| Li, G | 1 |
| Yamaza, T | 1 |
| Miura, Y | 1 |
| Bi, Y | 1 |
| Akiyama, K | 1 |
| Sonoyama, W | 1 |
| Patel, V | 1 |
| Gutkind, S | 1 |
| Young, M | 1 |
| Gronthos, S | 1 |
| Le, A | 1 |
| Wang, CY | 1 |
| Chen, W | 1 |
| Shi, S | 1 |
| Vestergaard, P | 1 |
| Steinberg, TH | 1 |
| Schwarz, P | 1 |
| Jørgensen, NR | 1 |
| Laria, A | 1 |
| Zoli, A | 1 |
| Gremese, E | 1 |
| Ferraccioli, GF | 1 |
| Chen, ZW | 1 |
| Wu, ZX | 1 |
| Sang, HX | 1 |
| Qin, GL | 1 |
| Wang, LS | 1 |
| Feng, J | 1 |
| Li, XJ | 1 |
| Wang, JC | 1 |
| Zhang, D | 1 |
| Guo, Y | 1 |
| Zhang, CY | 1 |
| Tian, Y | 1 |
| DI, JM | 1 |
| Qin, S | 1 |
| Moynihan, R | 1 |
| Bero, L | 1 |
| Ross-Degnan, D | 1 |
| Henry, D | 1 |
| Lee, K | 1 |
| Watkins, J | 1 |
| Mah, C | 1 |
| Soumerai, SB | 1 |
| Worobec, AS | 1 |
| Marshall, JK | 1 |
| Rainsford, KD | 1 |
| James, C | 1 |
| Hunt, RH | 1 |
| Ramanan, C | 1 |
| Khoury, G | 1 |
| Kolodny, AL | 1 |
| Klipper, AR | 1 |
| McBeath, AA | 1 |
| Pankow, W | 1 |
| Ehlenz, K | 1 |
| Buhr, T | 1 |
| Pflüger, KH | 1 |
| von Wichert, P | 1 |
| Ginsberg, JS | 1 |
| Hirsh, J | 1 |
| Niebyl, JR | 1 |
| Waters, DJ | 1 |
| Caywood, DD | 1 |
| Trachte, GJ | 1 |
| Turner, RT | 1 |
| Hodgson, SF | 1 |
| Reed, CE | 1 |
| Leung, DY | 1 |
| Key, L | 1 |
| Steinberg, JJ | 1 |
| Young, MC | 1 |
| Von Deck, M | 1 |
| Wilkinson, R | 1 |
| Geha, RS | 1 |
| Liakakos, D | 1 |
| Vlachos, P | 1 |
| Anoussakis, C | 1 |
4 reviews available for aspirin and Osteoporosis
| Article | Year |
|---|---|
Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections.
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Aspirin; Calcium, Dietary; Clopidogrel; Clostridioide | 2011 |
Treatment of systemic mast cell disorders.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Antineoplastic Agents; Aspirin; Cholinergic An | 2000 |
Use of antithrombotic agents during pregnancy.
Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Fetal Diseases; Hemorrhage; Humans; Oste | 1992 |
Drug therapy during pregnancy.
Topics: Anticonvulsants; Aspirin; Female; Fetus; Heparin; Humans; Osteoporosis; Pregnancy; Tocolytic Agents | 1991 |
1 trial available for aspirin and Osteoporosis
| Article | Year |
|---|---|
A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract.
Topics: Adult; Alendronate; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinopros | 2000 |
25 other studies available for aspirin and Osteoporosis
| Article | Year |
|---|---|
Association of Plasma High-Density Lipoprotein Cholesterol Level With Risk of Fractures in Healthy Older Adults.
Topics: Aged; Aspirin; Australia; Cholesterol; Cholesterol, HDL; Cohort Studies; Double-Blind Method; Female | 2023 |
NHANES cross sectional study of aspirin and fractures in the elderly.
Topics: Aged; Aged, 80 and over; Aspirin; Bone Density; Cross-Sectional Studies; Female; Fractures, Bone; Hi | 2023 |
Aspirin prevents estrogen deficiency-induced bone loss by inhibiting osteoclastogenesis and promoting osteogenesis.
Topics: Animals; Aspirin; Bone Resorption; Cell Differentiation; Estrogens; Mice; NF-kappa B; Osteoclasts; O | 2023 |
Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antirheumatic Agents; Aspirin; Drug Tapering; Europe; Fema | 2021 |
[Effect of low dose aspirin on osseointegration around titanium implants in osteoporotic rats].
Topics: Animals; Aspirin; Bone Screws; Female; Osseointegration; Osteoporosis; Ovariectomy; Rats; Rats, Spra | 2018 |
Anti-atherogenic properties of vitamin E, aspirin, and their combination.
Topics: Animals; Aspirin; Atherosclerosis; Bone Density; Drug Therapy, Combination; Male; Osteoporosis; Rats | 2018 |
Local administration of aspirin with β-tricalcium phosphate/poly-lactic-co-glycolic acid (β-TCP/PLGA) could enhance osteoporotic bone regeneration.
Topics: Animals; Aspirin; Biomarkers; Biomechanical Phenomena; Bone Regeneration; Calcium Phosphates; Diseas | 2019 |
Biophysics and the nonlinear dynamics instigated by a special hormone.
Topics: Aspirin; Biophysical Phenomena; Bone and Bones; Bone Resorption; Calcitonin; Drug Therapy, Combinati | 2020 |
Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study.
Topics: Age Factors; Aged; Aged, 80 and over; Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2014 |
Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats.
Topics: Animals; Aspirin; Biomarkers; Bone Density; Calcitonin; Female; Femur; Immunohistochemistry; Lumbar | 2015 |
Co-administration of aspirin and allogeneic adipose-derived stromal cells attenuates bone loss in ovariectomized rats through the anti-inflammatory and chemotactic abilities of aspirin.
Topics: Adipocytes; Animals; Aspirin; Bone Regeneration; Calcium; Chemotactic Factors; Female; In Vitro Tech | 2015 |
Aspirin prevents bone loss with little mechanical improvement in high-fat-fed ovariectomized rats.
Topics: Animals; Aspirin; Biomarkers; Biomechanical Phenomena; Body Weight; Bone Density; Diet, High-Fat; Fe | 2016 |
Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents.
Topics: Animals; Apoptosis; Aspirin; Bone Marrow Cells; Bone Resorption; CD4-Positive T-Lymphocytes; Humans; | 2008 |
Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Case-Control Studies; Clopidogrel; Dipyridamole; Drug | 2012 |
[Effect of aspirin administration for the treatment of osteoporosis in ovariectomized rat model].
Topics: Animals; Aspirin; Disease Models, Animal; Female; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Daw | 2011 |
[Effect of cyclooxygenase-2 on bone loss in ovariectomized rats].
Topics: Animals; Aspirin; Bone Density; Bone Resorption; Cyclooxygenase 2; Disease Models, Animal; Female; F | 2012 |
Coverage by the news media of the benefits and risks of medications.
Topics: Alendronate; Anticholesteremic Agents; Aspirin; Biomedical Research; Cardiovascular Diseases; Confli | 2000 |
Juvenile rheumatoid arthritis. (Retrospective study of thirty cases at West Virginia University Medical Center).
Topics: Adolescent; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Female; Gold; Humans; Male; Osteo | 1975 |
Bone and joint diseases in the elderly.
Topics: Activities of Daily Living; Adrenal Cortex Hormones; Age Factors; Aged; Anti-Inflammatory Agents; Ar | 1976 |
The aging skeleton. Osteoporosis and degenerative arthritis.
Topics: Age Factors; Aged; Aspirin; Estrogens; Female; Fracture Fixation; Humans; Ibuprofen; Indomethacin; J | 1975 |
[Osteoporotic vertebral fractures in systemic mastocytosis without skin involvement].
Topics: Aspirin; Bone Marrow Examination; Calcitonin; Calcium; Cholecalciferol; Diagnosis, Differential; Fem | 1992 |
Immobilization increases bone prostaglandin E. Effect of acetylsalicylic acid on disuse osteoporosis studied in dogs.
Topics: Absorptiometry, Photon; Alkaline Phosphatase; Animals; Aspirin; Bone and Bones; Calcium; Dogs; Femal | 1991 |
New therapeutic approaches in asthma.
Topics: Adrenergic beta-Agonists; Aerosols; Airway Obstruction; Aspirin; Asthma; Bronchi; Bronchodilator Age | 1986 |
Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome.
Topics: Aspirin; Bone Resorption; Child; Child, Preschool; Dinoprostone; Female; Humans; Hydroxyproline; Hyp | 1988 |
Effect of acetylsalicyclic acid (aspirin) on bone collagen in children.
Topics: Aspirin; Bone and Bones; Child; Child, Preschool; Collagen; Growth Disorders; Humans; Hydroxyproline | 1973 |