aspirin has been researched along with Osteoarthritis in 248 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine elevations in levels of serum glutamic oxaloacetic transaminase (SGOT) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) taking placebo, aspirin, or diclofenac, and to seek possible explanations for the occurrence of these elevations." | 10.17 | Differential effects of diclofenac and aspirin on serum glutamic oxaloacetic transaminase elevations in patients with rheumatoid arthritis and osteoarthritis. ( Anderson, W; Furst, DE, 1993) |
| "Among patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism." | 9.51 | Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial. ( Ackerman, I; Adie, S; Bastiras, D; Brighton, R; Buchbinder, R; Burns, AWR; Cashman, K; Chong, BH; Clavisi, O; Cripps, M; de Steiger, R; Dekkers, M; Dixon, M; Ellis, A; Graves, SE; Griffith, EC; Hale, D; Hansen, A; Harris, A; Harris, IA; Hau, R; Horsley, M; James, D; Kelly, TL; Khorshid, O; Kuo, L; Lewis, P; Lieu, D; Lorimer, M; MacDessi, S; McCombe, P; McDougall, C; Mulford, J; Naylor, JM; Page, RS; Pratt, N; Radovanovic, J; Sidhu, VS; Solomon, M; Sorial, R; Summersell, P; Tran, P; Walter, WL; Webb, S; Wilson, C; Wysocki, D, 2022) |
| "We performed a placebo-controlled, randomized study to address whether celecoxib or ibuprofen undermines the functional range of inhibition of platelet cyclooxygenase (COX)-1 activity by aspirin in patients with osteoarthritis and stable ischemic heart disease." | 9.12 | Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease. ( Capone, ML; D'Amelio, E; De Caterina, R; Grana, M; Patrignani, P; Patrono, C; Price, TS; Renda, G; Sacchetta, D; Santarelli, F; Sciulli, MG; Tacconelli, S; Zimarino, M; Zurro, M, 2006) |
| "To determine the cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib." | 9.12 | Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib. ( Abramson, SB; Chesebro, JH; Farkouh, ME; Fuster, V; Greenberg, JD; Hochman, JS; Jeger, RV; Kirshner, H; Lay, CL; Matchaba, PT; Mellein, B; Ramanathan, K; Ruland, S; Verheugt, FW, 2007) |
| "To evaluate the risk of gastrointestinal (GI) symptoms and ulcers associated to the use of low-dose aspirin (ASA) among patients with rheumatoid arthritis (RA) and osteoarthritis (OA) treated with cyclooxygenase-2 (COX-2) drugs, to clarify the controversy in the literature." | 9.12 | The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestinal ulcers associated to cyclooxygenase-2 selective inhibitors. ( Benito-Garcia, E; Michaud, K; Wolfe, F, 2007) |
| "To evaluate the relative gastrointestinal (GI) tolerability of celecoxib and rofecoxib in elderly hypertensive patients with osteoarthritis (OA) with or without coadministration of low dose aspirin (ASA) (< or = 325 mg daily)." | 9.11 | Cyclooxygenase-2 specific inhibitors and upper gastrointestinal tolerability in patients with osteoarthritis receiving concomitant low dose aspirin: pooled analysis of 2 trials. ( Bello, AE; Fort, JG; Goldstein, JL; Spalding, W; Suh, S, 2005) |
| "To assess the tolerability of rofecoxib compared with naproxen for treatment of osteoarthritis." | 9.10 | Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial. ( Dixon, ME; Geba, GP; Johansson, G; Lisse, JR; Mollen, AJ; Perlman, M; Polis, AB; Schechtman, J; Shoemaker, JR; Skalky, CS, 2003) |
| "Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids." | 9.06 | Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. ( Calzada, R; Dhar, R; Jaszewski, R, 1989) |
| "The safety and efficacy of nabumetone (1,000 mg at bedtime) were compared with those of aspirin (900 mg four times daily) in the treatment of osteoarthritis in adult patients in a private practice setting as part of a six-month, double-blind, controlled, randomized, parallel group study." | 9.06 | Results of a six-month study comparing the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis. ( Mullen, BJ, 1987) |
| "Despite a wide range of study designs, a multiplicity of international trials of diclofenac in osteoarthritis have disclosed similar results." | 9.06 | International experiences with diclofenac in osteoarthritis. ( Altman, R, 1986) |
| "The role of diclofenac sodium in patients with symptomatic osteoarthritis of the hip or knee has been evaluated in five prospective, randomized, double-blind, controlled trials with placebo, aspirin, and naproxen conducted in the United States." | 9.06 | Efficacy of diclofenac in osteoarthritis. Experience in the United States. ( Ward, JR, 1986) |
| "The analgesic efficacy of flurbiprofen (Ansaid, Upjohn) and aspirin were compared in a 12-week, double-blind, randomized, parallel, multicenter study of 147 patients with osteoarthritis of the knee." | 9.06 | Treatment of osteoarthritis of the knee. A comparison of flurbiprofen and aspirin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Porter, GH; Turner, LF, 1986) |
| "One hundred forty-one subjects with osteoarthritis completed this double-blind, multicenter, crossover trial comparing four nonsteroidal anti-inflammatory (NSAI) agents after single-blind aspirin stabilization." | 9.05 | Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles. ( Caldwell, JR; Crain, D; Hoffmeister, RT; Kantrowitz, F; Lloyd, RJ; Nussdorf, RT; Repice, MR; Schmid, FR, 1983) |
| "This six-month double-blind, parallel-design study compared the efficacy and safety of piroxicam 20 mg and 40 mg with that of 12 tablets of aspirin in 29 patients with osteoarthritis and demonstrated that both piroxicam doses were superior to aspirin in the treatment of osteoarthritis with respect to physicians' opinion of improvement and ease of movement." | 9.05 | Piroxicam in osteoarthritis: a controlled long-term study. ( Stevens, MB; Sutton, JD; Zizic, TM, 1983) |
| "Fenbufen (Cinopal) has been evaluated extensively in 155 clinical trials, including 102 in rheumatoid arthritis and 53 in osteoarthritis." | 9.05 | Overview of efficacy of fenbufen in rheumatoid arthritis and osteoarthritis. ( Bernstein, J, 1983) |
| "Benoxaprofen was compared to aspirin or to ibuprofen in 2 28-wk multiclinic double-blind trials in patients with symptomatic osteoarthritis of the knees or hips." | 9.05 | Long-term treatment of symptomatic osteoarthritis with benoxaprofen. Double-blind comparison with aspirin and ibuprofen. ( Alarcon-Segovia, D, 1980) |
| "The effectiveness, safety and acceptability of indoprofen (IP) and acetylsalicylic acid (ASA) were assessed in patients with osteoarthritis, in a double-blind comparative trial." | 9.05 | Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis. ( Katona, G, 1981) |
| "In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo." | 9.04 | Ibuprofen in osteoarthritis. ( Brooks, CD; Donaldson, MS; Giansiracusa, JE; Koonce, ML; Lefton, TE; Ruoff, GE, 1977) |
| "Thirty patients with osteoarthritis of knees or hips took part in a double-blind randomized 12-week inter-group clinical trial of diflunisal 250 mg to 375 mg twice daily against aspirin 500 mg to 750 mg four times daily using the double-placebo technique." | 9.04 | A clinical trial of diflunisal against aspirin in osteoarthritis. ( Grayson, MF, 1978) |
| "The objective of the study was to compare efficacy and safety of Fenbufen and Aspirin in osteoarthritis." | 9.04 | Clinical comparison of fenbufen and aspirin in osteoarthritis. ( Valtonen, EJ, 1979) |
| "To determine the effectiveness of naproxen in the treatment of osteoarthritis of the knee joint, a double-blind cross-over study against placebo was carried out on 61 patients." | 9.04 | Double-blind study of Naproxen in osteoarthritis of the knee joint. ( Ito, T; Mori, E; Muroga, T; Nakajima, A; Tanaka, S, 1976) |
| "In a randomized, double-blind, six-week, crossover comparison, fenoprofen (200 mg to 600 mg every six hours) had similar efficacy to aspirin (325 mg to 975 mg every six hours) in the treatment of patients with osteoarthritis affecting the spine, hip, knee, or shoulder." | 9.04 | Double-blind crossover study of fenoprofen and aspirin in osteoarthritis. ( Diamond, HS, 1976) |
| "This study, designed to evaluate fenoprofen in patients with osteoarthritis, consisted of two phases: I." | 9.04 | Fenoprofen therapy in large-joint osteoarthritis: double-blind comparison with aspirin and longterm experience. ( Brooke, JW, 1976) |
| "A double-blind, crossover study compared the use of fenoprofen to aspirin in patients with osteoarthritis of large joints, most of them with knee involvement." | 9.04 | Controlled evaluation of fenoprofen in geriatric patients with osteoarthritis. ( Jain, A; McMahon, FG; Onel, A, 1976) |
| "A prespecified pooled intent-to-treat analysis of three double-blind randomised comparisons of etoricoxib (60 or 90 mg daily) and diclofenac (150 mg daily) in 34 701 patients with osteoarthritis or rheumatoid arthritis was done for upper gastrointestinal clinical events (bleeding, perforation, obstruction, or ulcer) and the subset of complicated events (perforation, obstruction, witnessed ulcer bleeding, or significant bleeding)." | 8.84 | Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. ( Cannon, CP; Cryer, B; Curtis, SP; Kaur, A; Laine, L, 2007) |
| "To compare the incidence of abdominal pain, dyspepsia and/or nausea associated with valdecoxib, nonspecific nonsteroidal anti-inflammatory drugs and placebo in patients with rheumatoid arthritis and osteoarthritis." | 8.82 | Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis. ( Eisen, GM; Goldstein, JL; Hanna, DB; Rublee, DA, 2005) |
| "To determine the efficacy, gastrointestinal safety, and tolerability of celecoxib (a cyclo-oxygenase 2 (COX 2) inhibitor) used in the treatment of osteoarthritis and rheumatoid arthritis." | 8.81 | Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. ( Bradley, MD; Deeks, JJ; Smith, LA, 2002) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 8.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "Nonsteroidal antiinf lammatory drugs (NSAIDs) remain the mainstay of the pharmacologic management for relieving osteoarthritis pain, and low-dose aspirin is often prescribed to osteoarthritis patients who are at high risk of cardiovascular disease (CVD)." | 8.31 | Interactions of Nonsteroidal Antiinflammatory Drugs and Aspirin and Risk of Cardiovascular Disease in Patients With Osteoarthritis. ( Lane, NE; Lei, G; Li, X; Wei, J; Zeng, C; Zhang, Y, 2023) |
| " The MEDAL program is designed to provide a precise estimate of the relative cardiovascular event rates with the COX-2 selective inhibitor etoricoxib in comparison to the traditional NSAID diclofenac in patients with osteoarthritis and rheumatoid arthritis." | 7.73 | Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. ( Bolognese, JA; Cannon, CP; Curtis, SP; Laine, L, 2006) |
| "The safety of flurbiprofen (Ansaid, Upjohn) was assessed after pooling data on kidney and liver function collected from nine separate phase III clinical trials involving 1,677 patients (941 receiving flurbiprofen and 736 receiving comparison drugs) with ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis." | 7.67 | Safety of flurbiprofen in the treatment of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. A summary of liver and kidney assay data. ( Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
| "Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1." | 6.69 | Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000) |
| "The misoprostol/aspirin-treated group had significantly (P < 0." | 6.67 | Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs. ( Boudrieau, RJ; Labato, MA; Matz, ME; Murtaugh, RJ, 1993) |
| " The most common adverse effects that occurred were related to the gastrointestinal tract, nervous system, skin, and special senses." | 6.67 | Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. ( Fleischmann, RM, 1992) |
| "Aspirin-treated patients experienced a greater frequency of withdrawal from the study because of adverse experiences (34 percent versus 13 percent), a greater incidence of having at least one treatment-related adverse experience (73 percent versus 52 percent), a greater percentage of patients with at least one moderate or severe treatment-related adverse experience (47 percent versus 22 percent), and a greater percentage of patients with treatment-related adverse experiences affecting the gastrointestinal system (43 percent versus 32 percent) or the inner ear (32 percent versus 10 percent)." | 6.66 | Comparison of the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis in adults. ( Appelrouth, DJ; Baim, S; Chang, RW; Cohen, MH; Englund, DW; Germain, BF; Hartman, SS; Jaffer, A; Mullen, BJ; Smith, FE, 1987) |
| "Suprofen was comparable to aspirin in the relief of pain and improvement in activity impairment." | 6.65 | Long-term clinical evaluation of suprofen and aspirin in patients with osteoarthritis. ( Willkens, RF, 1983) |
| "Each treatment (indoprofen 300 or 600 mg/day, ASA 1500 + diazepam 6 mg/day, and matching placebo) was administered for 7 days." | 6.65 | Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis. ( Bergamini, N; Groppi, W; Mandelli, V; Valtonen, E, 1981) |
| "indomethacin was compared to a single daily dose of 600 mg benoxaprofen." | 6.65 | Activated osteoarthrosis (osteoarthritis) and its treatment with indomethacin and benoxaprofen: a double-blind crossover study. ( Bach, GL, 1982) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "To examine elevations in levels of serum glutamic oxaloacetic transaminase (SGOT) in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) taking placebo, aspirin, or diclofenac, and to seek possible explanations for the occurrence of these elevations." | 6.17 | Differential effects of diclofenac and aspirin on serum glutamic oxaloacetic transaminase elevations in patients with rheumatoid arthritis and osteoarthritis. ( Anderson, W; Furst, DE, 1993) |
| "Among patients undergoing hip or knee arthroplasty for osteoarthritis, aspirin compared with enoxaparin resulted in a significantly higher rate of symptomatic VTE within 90 days, defined as below- or above-knee DVT or pulmonary embolism." | 5.51 | Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial. ( Ackerman, I; Adie, S; Bastiras, D; Brighton, R; Buchbinder, R; Burns, AWR; Cashman, K; Chong, BH; Clavisi, O; Cripps, M; de Steiger, R; Dekkers, M; Dixon, M; Ellis, A; Graves, SE; Griffith, EC; Hale, D; Hansen, A; Harris, A; Harris, IA; Hau, R; Horsley, M; James, D; Kelly, TL; Khorshid, O; Kuo, L; Lewis, P; Lieu, D; Lorimer, M; MacDessi, S; McCombe, P; McDougall, C; Mulford, J; Naylor, JM; Page, RS; Pratt, N; Radovanovic, J; Sidhu, VS; Solomon, M; Sorial, R; Summersell, P; Tran, P; Walter, WL; Webb, S; Wilson, C; Wysocki, D, 2022) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 5.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| " Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity." | 5.32 | Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003) |
| " Osteoarthritis or rheumatoid arthritis patients, needing ongoing NSAID treatment, were randomised to receive celecoxib 100-200 mg b." | 5.27 | Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial. ( Bao, W; Borer, JS; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Nissen, SE; Solomon, DH; Stevens, T; Vargo, J; Walker, C; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND, 2018) |
| "We measured the urinary excretion of ATL in 24 patients with both ischaemic heart disease and osteoarthritis, chronically treated with aspirin and co-administered celecoxib 200 mg b." | 5.14 | Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors. ( De Caterina, R; Renda, G; Romano, M; Zurro, M, 2010) |
| " Due to the concomitant use of aspirin or warfarin in many osteoarthritis (OA) patients with increased cardiovascular risk, we felt it necessary to assess the anticoagulation properties of flavocoxid." | 5.14 | Flavocoxid, an anti-inflammatory agent of botanical origin, does not affect coagulation or interact with anticoagulation therapies. ( Burnett, BP; Jia, Q; Levy, RM; Pillai, L; Yimam, M; Zhao, Y, 2010) |
| "We performed a placebo-controlled, randomized study to address whether celecoxib or ibuprofen undermines the functional range of inhibition of platelet cyclooxygenase (COX)-1 activity by aspirin in patients with osteoarthritis and stable ischemic heart disease." | 5.12 | Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease. ( Capone, ML; D'Amelio, E; De Caterina, R; Grana, M; Patrignani, P; Patrono, C; Price, TS; Renda, G; Sacchetta, D; Santarelli, F; Sciulli, MG; Tacconelli, S; Zimarino, M; Zurro, M, 2006) |
| "To determine the cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib." | 5.12 | Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib. ( Abramson, SB; Chesebro, JH; Farkouh, ME; Fuster, V; Greenberg, JD; Hochman, JS; Jeger, RV; Kirshner, H; Lay, CL; Matchaba, PT; Mellein, B; Ramanathan, K; Ruland, S; Verheugt, FW, 2007) |
| "To evaluate the risk of gastrointestinal (GI) symptoms and ulcers associated to the use of low-dose aspirin (ASA) among patients with rheumatoid arthritis (RA) and osteoarthritis (OA) treated with cyclooxygenase-2 (COX-2) drugs, to clarify the controversy in the literature." | 5.12 | The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestinal ulcers associated to cyclooxygenase-2 selective inhibitors. ( Benito-Garcia, E; Michaud, K; Wolfe, F, 2007) |
| "Subjects 18 years or older with osteoarthritis, without gastroduodenal ulcer or erosive esophagitis at baseline endoscopy, and a cardiovascular indication for prophylaxis low-dose (81 or 325 mg) aspirin were prescribed open-label aspirin and blindly randomized to celecoxib 200 mg/day or naproxen 500 mg twice daily plus lansoprazole 30 mg once daily." | 5.12 | Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. ( Amer, F; Cryer, B; Goldstein, JL; Hunt, B, 2007) |
| "The Therapeutic Arthritis Research and Gastrointestinal Event Trial was a randomized, double-blind, 52-week study of lumiracoxib 400 mg once daily (two to four times the recommended dose for osteoarthritis) versus naproxen 500 mg twice daily or ibuprofen 800 mg three-times daily in patients with osteoarthritis." | 5.11 | Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics. ( Ehrsam, E; Farkouh, M; Gitton, X; Hawkey, CJ; Huels, J; Richardson, P, 2004) |
| "Osteoarthritis patients > or =50 years of age without ulcers or erosive esophagitis at baseline endoscopy were assigned randomly to placebo, enteric-coated aspirin 81 mg/day, rofecoxib 25 mg combined with aspirin 81 mg/day, or ibuprofen 800 mg 3 times a day." | 5.11 | Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial. ( Laine, L; Maller, ES; Quan, H; Simon, T; Yu, C, 2004) |
| "To evaluate the relative gastrointestinal (GI) tolerability of celecoxib and rofecoxib in elderly hypertensive patients with osteoarthritis (OA) with or without coadministration of low dose aspirin (ASA) (< or = 325 mg daily)." | 5.11 | Cyclooxygenase-2 specific inhibitors and upper gastrointestinal tolerability in patients with osteoarthritis receiving concomitant low dose aspirin: pooled analysis of 2 trials. ( Bello, AE; Fort, JG; Goldstein, JL; Spalding, W; Suh, S, 2005) |
| "To assess the tolerability of rofecoxib compared with naproxen for treatment of osteoarthritis." | 5.10 | Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial. ( Dixon, ME; Geba, GP; Johansson, G; Lisse, JR; Mollen, AJ; Perlman, M; Polis, AB; Schechtman, J; Shoemaker, JR; Skalky, CS, 2003) |
| " In the upper GI endoscopy study, 19% of subjects receiving naproxen (6 of 32) developed gastric ulcers, whereas no ulcers occurred in subjects receiving SC-58635 or placebo." | 5.08 | Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. ( Geis, GS; Hubbard, RC; Isakson, PC; Lanza, FL; Lipsky, PE; Schwartz, BD; Simon, LS; Talwalker, S, 1998) |
| "Three randomized, placebo-controlled multiclinic trials involving arbaprostil dosages of (a) 10 micrograms; (b) 25 micrograms; and (c) 10, 25, or 50 micrograms orally for 4 wk in patients older than 18 yr with rheumatoid arthritis or osteoarthritis who had endoscopically documented nonsteroidal antiinflammatory drug-associated gastric mucosal damage were conducted in the United States." | 5.06 | A report of three multiclinic trials evaluating arbaprostil in arthritic patients with ASA/NSAID gastric mucosal damage. The Upjohn Company Arbaprostil ASA/NSAID Gastric Mucosal Damage Treatment Study Groups. ( Champion, C; Euler, AR; Fleischmann, R; Jaszewski, R; Le, V; Rao, J; Raskin, J; Razzaque, M; Safdi, M; Welsh, J, 1990) |
| "Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids." | 5.06 | Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. ( Calzada, R; Dhar, R; Jaszewski, R, 1989) |
| "The safety and efficacy of nabumetone (1,000 mg at bedtime) were compared with those of aspirin (900 mg four times daily) in the treatment of osteoarthritis in adult patients in a private practice setting as part of a six-month, double-blind, controlled, randomized, parallel group study." | 5.06 | Results of a six-month study comparing the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis. ( Mullen, BJ, 1987) |
| "Despite a wide range of study designs, a multiplicity of international trials of diclofenac in osteoarthritis have disclosed similar results." | 5.06 | International experiences with diclofenac in osteoarthritis. ( Altman, R, 1986) |
| "The role of diclofenac sodium in patients with symptomatic osteoarthritis of the hip or knee has been evaluated in five prospective, randomized, double-blind, controlled trials with placebo, aspirin, and naproxen conducted in the United States." | 5.06 | Efficacy of diclofenac in osteoarthritis. Experience in the United States. ( Ward, JR, 1986) |
| "The incidence of potentially serious drug-related elevations of BUN or serum creatinine was examined among 1468 patients with rheumatoid arthritis or osteoarthritis who took daily therapeutic doses of aspirin, ibuprofen, or oxaprozin, an investigational nonsteroidal antiinflammatory drug (NSAID), in multicenter clinical trials." | 5.06 | Renal safety of two analgesics used over the counter: ibuprofen and aspirin. ( Bonney, SL; Hedrich, DA; Northington, RS; Walker, BR, 1986) |
| "The analgesic efficacy of flurbiprofen (Ansaid, Upjohn) and aspirin were compared in a 12-week, double-blind, randomized, parallel, multicenter study of 147 patients with osteoarthritis of the knee." | 5.06 | Treatment of osteoarthritis of the knee. A comparison of flurbiprofen and aspirin. ( Brinn, EL; Lamborn, KR; Lomen, PL; Porter, GH; Turner, LF, 1986) |
| "One hundred forty-one subjects with osteoarthritis completed this double-blind, multicenter, crossover trial comparing four nonsteroidal anti-inflammatory (NSAI) agents after single-blind aspirin stabilization." | 5.05 | Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles. ( Caldwell, JR; Crain, D; Hoffmeister, RT; Kantrowitz, F; Lloyd, RJ; Nussdorf, RT; Repice, MR; Schmid, FR, 1983) |
| "This six-month double-blind, parallel-design study compared the efficacy and safety of piroxicam 20 mg and 40 mg with that of 12 tablets of aspirin in 29 patients with osteoarthritis and demonstrated that both piroxicam doses were superior to aspirin in the treatment of osteoarthritis with respect to physicians' opinion of improvement and ease of movement." | 5.05 | Piroxicam in osteoarthritis: a controlled long-term study. ( Stevens, MB; Sutton, JD; Zizic, TM, 1983) |
| "Fenbufen (Cinopal) has been evaluated extensively in 155 clinical trials, including 102 in rheumatoid arthritis and 53 in osteoarthritis." | 5.05 | Overview of efficacy of fenbufen in rheumatoid arthritis and osteoarthritis. ( Bernstein, J, 1983) |
| " Gastrointestinal side effects with benoxaprofen compared favorably to those reported during aspirin and ibuprofen therapy, with peptic ulcers reported in 0." | 5.05 | Long-term safety of benoxaprofen. ( Mikulaschek, WM, 1980) |
| "Benoxaprofen was compared to aspirin or to ibuprofen in 2 28-wk multiclinic double-blind trials in patients with symptomatic osteoarthritis of the knees or hips." | 5.05 | Long-term treatment of symptomatic osteoarthritis with benoxaprofen. Double-blind comparison with aspirin and ibuprofen. ( Alarcon-Segovia, D, 1980) |
| " The first compared tolmetin sodium, phenylbutazone and placebo in rheumatoid arthritis." | 5.05 | Clinical experience with tolmetin sodium. ( Balme, HW; Huskisson, EC; Wojtulewski, JA, 1980) |
| "The effectiveness, safety and acceptability of indoprofen (IP) and acetylsalicylic acid (ASA) were assessed in patients with osteoarthritis, in a double-blind comparative trial." | 5.05 | Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis. ( Katona, G, 1981) |
| "In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo." | 5.04 | Ibuprofen in osteoarthritis. ( Brooks, CD; Donaldson, MS; Giansiracusa, JE; Koonce, ML; Lefton, TE; Ruoff, GE, 1977) |
| "Trials in patients with rheumatoid arthritis and osteoarthritis showed sulindac to be an analgesic with anti-inflammatory properties and at least as effective as aspirin." | 5.04 | Sulindac. Trials of a new anti-inflammatory drug. ( Huskisson, EC; Scott, J, 1978) |
| "Two double-blind inter-group trials were carried out in which diflunisal was compared for 12 weeks against aspirin in 30 patients with osteoarthritis of knees or hips, and against naproxen for 8 weeks in 20 patients with osteoarthritic knees." | 5.04 | Two trials of diflunisal in osteoarthritis. ( Grayson, MF, 1978) |
| "Thirty patients with osteoarthritis of knees or hips took part in a double-blind randomized 12-week inter-group clinical trial of diflunisal 250 mg to 375 mg twice daily against aspirin 500 mg to 750 mg four times daily using the double-placebo technique." | 5.04 | A clinical trial of diflunisal against aspirin in osteoarthritis. ( Grayson, MF, 1978) |
| "The objective of the study was to compare efficacy and safety of Fenbufen and Aspirin in osteoarthritis." | 5.04 | Clinical comparison of fenbufen and aspirin in osteoarthritis. ( Valtonen, EJ, 1979) |
| "To determine the effectiveness of naproxen in the treatment of osteoarthritis of the knee joint, a double-blind cross-over study against placebo was carried out on 61 patients." | 5.04 | Double-blind study of Naproxen in osteoarthritis of the knee joint. ( Ito, T; Mori, E; Muroga, T; Nakajima, A; Tanaka, S, 1976) |
| "In a randomized, double-blind, six-week, crossover comparison, fenoprofen (200 mg to 600 mg every six hours) had similar efficacy to aspirin (325 mg to 975 mg every six hours) in the treatment of patients with osteoarthritis affecting the spine, hip, knee, or shoulder." | 5.04 | Double-blind crossover study of fenoprofen and aspirin in osteoarthritis. ( Diamond, HS, 1976) |
| "This study, designed to evaluate fenoprofen in patients with osteoarthritis, consisted of two phases: I." | 5.04 | Fenoprofen therapy in large-joint osteoarthritis: double-blind comparison with aspirin and longterm experience. ( Brooke, JW, 1976) |
| "A double-blind, crossover study compared the use of fenoprofen to aspirin in patients with osteoarthritis of large joints, most of them with knee involvement." | 5.04 | Controlled evaluation of fenoprofen in geriatric patients with osteoarthritis. ( Jain, A; McMahon, FG; Onel, A, 1976) |
| "Eye evaluations before and after 24 weeks of treatment with either ibuprofen (Motrin) or aspirin did not show eye toxicity with either drug in a double-blind study of 78 patients with osteoarthritis." | 5.04 | Ibuprofen and visual function. Prospective evaluation. ( Brooks, CD; Cross, CJ; Melluish, JW; Ruoff, G; Sanborn, EC, 1975) |
| "A prespecified pooled intent-to-treat analysis of three double-blind randomised comparisons of etoricoxib (60 or 90 mg daily) and diclofenac (150 mg daily) in 34 701 patients with osteoarthritis or rheumatoid arthritis was done for upper gastrointestinal clinical events (bleeding, perforation, obstruction, or ulcer) and the subset of complicated events (perforation, obstruction, witnessed ulcer bleeding, or significant bleeding)." | 4.84 | Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. ( Cannon, CP; Cryer, B; Curtis, SP; Kaur, A; Laine, L, 2007) |
| "To compare the incidence of abdominal pain, dyspepsia and/or nausea associated with valdecoxib, nonspecific nonsteroidal anti-inflammatory drugs and placebo in patients with rheumatoid arthritis and osteoarthritis." | 4.82 | Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis. ( Eisen, GM; Goldstein, JL; Hanna, DB; Rublee, DA, 2005) |
| "To determine the efficacy, gastrointestinal safety, and tolerability of celecoxib (a cyclo-oxygenase 2 (COX 2) inhibitor) used in the treatment of osteoarthritis and rheumatoid arthritis." | 4.81 | Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. ( Bradley, MD; Deeks, JJ; Smith, LA, 2002) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 4.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "Nonsteroidal antiinf lammatory drugs (NSAIDs) remain the mainstay of the pharmacologic management for relieving osteoarthritis pain, and low-dose aspirin is often prescribed to osteoarthritis patients who are at high risk of cardiovascular disease (CVD)." | 4.31 | Interactions of Nonsteroidal Antiinflammatory Drugs and Aspirin and Risk of Cardiovascular Disease in Patients With Osteoarthritis. ( Lane, NE; Lei, G; Li, X; Wei, J; Zeng, C; Zhang, Y, 2023) |
| "The objective of this clinical study is to evaluate possible interactions between antiplatelet agents, anticoagulants, thyroid hormone replacement therapy and a formulation of curcumin (Meriva®) that resulted effective for the complementary treatment of osteoarthritis." | 3.88 | Interaction study between antiplatelet agents, anticoagulants, thyroid replacement therapy and a bioavailable formulation of curcumin (Meriva®). ( Belcaro, G; Cotellese, R; Dugall, M; Eggenhoffner, R; Giacomelli, L; Hosoi, M; Hu, S; Ledda, A; Peterzan, P; Riva, A; Togni, S, 2018) |
| " The MEDAL program is designed to provide a precise estimate of the relative cardiovascular event rates with the COX-2 selective inhibitor etoricoxib in comparison to the traditional NSAID diclofenac in patients with osteoarthritis and rheumatoid arthritis." | 3.73 | Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. ( Bolognese, JA; Cannon, CP; Curtis, SP; Laine, L, 2006) |
| "To investigate recent national trends in nonsteroidal antiinflammatory drug (NSAID) and acetaminophen use for osteoarthritis (OA)." | 3.71 | Trends in medication use for osteoarthritis treatment. ( Ausiello, JC; Stafford, RS, 2002) |
| " Neither indomethacin nor aspirin showed any effect in preventing osteoarthritis progression." | 3.69 | An experimental model of osteoarthritis in rabbit. ( Chang, DM; Chang, ML; Chen, CM; Chu, SJ; Hsu, CM; Kuo, SY, 1994) |
| " Flurbiprofen (Ansaid) is a new NSAID for the treatment of rheumatoid arthritis and osteoarthritis." | 3.68 | Nonsteroidal antiinflammatory drug desensitization using flurbiprofen (Ansaid) ( Brown, JS; Douglas, DM; Ward, L, 1993) |
| " Of the fifty-eight patients who had received aspirin throughout their course in the hospital, two (3 per cent) had severe ectopic ossification (grade III or IV8)." | 3.68 | Effect of aspirin on heterotopic ossification after total hip arthroplasty in men who have osteoarthrosis. ( Pagnani, MJ; Pellicci, PM; Salvati, EA, 1991) |
| " Therapeutic levels of aspirin in vivo had a similar adverse effect on degenerating cartilage, as noted in two canine models of osteoarthritis and cartilage atrophy." | 3.67 | Effects of salicylates and other nonsteroidal anti-inflammatory drugs on articular cartilage. ( Brandt, KD; Palmoski, MJ, 1984) |
| "The traditional "aspirin first" approach to the treatment of osteoarthritis and rheumatoid arthritis is undergoing serious reappraisal." | 3.67 | Pain and inflammation. ( Calin, A, 1984) |
| "The safety of flurbiprofen (Ansaid, Upjohn) was assessed after pooling data on kidney and liver function collected from nine separate phase III clinical trials involving 1,677 patients (941 receiving flurbiprofen and 736 receiving comparison drugs) with ankylosing spondylitis, osteoarthritis, or rheumatoid arthritis." | 3.67 | Safety of flurbiprofen in the treatment of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. A summary of liver and kidney assay data. ( Lamborn, KR; Lomen, PL; Turner, LF, 1986) |
| "Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness." | 3.66 | An update on long-term efficacy and safety with benoxaprofen. ( Mikulaschek, WM, 1982) |
| " Levels of PGB (presumed to arise from PGE) in synovial fluids are elevated in the majority of a group of patients with inflammatory rheumatic diseases, as compared to similar patients treated with aspirin and indomethacin and patients with osteoarthritis." | 3.65 | Prostaglandins in the rheumatic diseases. ( Levine, L; McGuire, MB; Robinson, DR, 1975) |
| "The new antirheumatic agents, fenoprofen calcium, naproxen, and tolmetin sodium, are effective in the management of rheumatoid arthritis." | 3.65 | New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin). ( Lewis, JR, 1977) |
| " Phenylbutazone (Butazolidin) is probably the drug of choice for acute gout and is also effective in ankylosing spondylitis, Reiter's syndrome, and psoriatic arthritis." | 3.65 | Rheumatic diseases. 2. Therapeutic considerations. ( Biundo, JJ; Gum, OB; Weiss, TE, 1976) |
| "Ibuprofen is a new, mild analgesic agent that may be useful in the symptomatic treatment of rheumatoid arthritis and osteoarthritis." | 3.65 | Evaluation of ibuprofen (Motrin). A new antirheumatic agent. ( Lewis, JR, 1975) |
| "A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy." | 3.65 | Aspirin and the kidney. New Zealand Rheumatism Association Study. ( , 1974) |
| " In the pooled analysis from all five studies, incidences of treatment-emergent adverse events (AEs) (including prespecified NSAID-associated upper GI AEs and cardiovascular AEs), serious AEs, and AE-related discontinuations were stratified by LDA subgroups." | 2.79 | Impact of concomitant low-dose aspirin on the safety and tolerability of naproxen and esomeprazole magnesium delayed-release tablets in patients requiring chronic nonsteroidal anti-inflammatory drug therapy: an analysis from 5 Phase III studies. ( Angiolillo, DJ; Datto, C; Raines, S; Yeomans, ND, 2014) |
| "Treatment with carprofen decreased clot strength and platelet aggregation." | 2.73 | Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs. ( Brainard, BM; Budsberg, SC; Callan, MB; Driessen, B; Meredith, CP; Otto, CM; Shofer, FS, 2007) |
| "Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1." | 2.69 | Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000) |
| "The misoprostol/aspirin-treated group had significantly (P < 0." | 2.67 | Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs. ( Boudrieau, RJ; Labato, MA; Matz, ME; Murtaugh, RJ, 1993) |
| " The most common adverse effects that occurred were related to the gastrointestinal tract, nervous system, skin, and special senses." | 2.67 | Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. ( Fleischmann, RM, 1992) |
| "Data from 58 premarketing studies of the nonsteroidal antiinflammatory drug flurbiprofen were pooled for analyses of adverse drug reactions (ADRs)." | 2.67 | Clinical safety of flurbiprofen. ( Assenzo, JR; Brooks, CD; Defesche, CL; Johnson, JH; Linet, OI; Schellenberg, D; Teoh, KW; Turner, LF, 1990) |
| "When aspirin was ceased, blood loss returned more rapidly towards normal in the Ostoprin group (p less than 0." | 2.66 | Gastrointestinal blood loss from a new buffered aspirin (Ostoprin): measurement by radiochromium and Hemoquant techniques. ( Barraclough, D; Deacon, M; Lynch, NM; McHutchison, JG; St John, DJ; Young, GP, 1989) |
| "Aspirin-treated patients experienced a greater frequency of withdrawal from the study because of adverse experiences (34 percent versus 13 percent), a greater incidence of having at least one treatment-related adverse experience (73 percent versus 52 percent), a greater percentage of patients with at least one moderate or severe treatment-related adverse experience (47 percent versus 22 percent), and a greater percentage of patients with treatment-related adverse experiences affecting the gastrointestinal system (43 percent versus 32 percent) or the inner ear (32 percent versus 10 percent)." | 2.66 | Comparison of the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis in adults. ( Appelrouth, DJ; Baim, S; Chang, RW; Cohen, MH; Englund, DW; Germain, BF; Hartman, SS; Jaffer, A; Mullen, BJ; Smith, FE, 1987) |
| "Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin." | 2.66 | Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985) |
| " Adverse experiences were infrequent and generally mild or transient." | 2.66 | Worldwide clinical safety experience with diclofenac. ( Willkens, RF, 1985) |
| "Aspirin was significantly more effective than placebo in only three assessments: two of the range of motion of the knee joint and one of pain while standing." | 2.65 | Etodolac, aspirin, and placebo in patients with degenerative joint disease: a twelve-week study. ( Andelman, SY, 1983) |
| "Suprofen was comparable to aspirin in the relief of pain and improvement in activity impairment." | 2.65 | Long-term clinical evaluation of suprofen and aspirin in patients with osteoarthritis. ( Willkens, RF, 1983) |
| "Each treatment (indoprofen 300 or 600 mg/day, ASA 1500 + diazepam 6 mg/day, and matching placebo) was administered for 7 days." | 2.65 | Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis. ( Bergamini, N; Groppi, W; Mandelli, V; Valtonen, E, 1981) |
| "indomethacin was compared to a single daily dose of 600 mg benoxaprofen." | 2.65 | Activated osteoarthrosis (osteoarthritis) and its treatment with indomethacin and benoxaprofen: a double-blind crossover study. ( Bach, GL, 1982) |
| " The most credited pathogenetic hypothesis to explain the association between chronic use of coxibs and CV risk seems to be related to a trombophilic effect due to an imbalance of prothrombotic and antithrombotic factors." | 2.46 | Coxibs: a significant therapeutic opportunity. ( Adami, S; Gatti, D, 2010) |
| " In the VIGOR gastrointestinal outcomes trial of >8000 patients, naproxen (an NSAID with aspirin-like sustained antiplatelet effects throughout its dosing interval) was associated with a significantly lower risk of CV events than was rofecoxib." | 2.42 | Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program. ( Gertz, BJ; Reicin, A; Sperling, RS; Weir, MR, 2003) |
| " Unlike selective COX-2 inhibitors, coadministration of licofelone and aspirin does not appear to be associated with an increase in gastrointestinal adverse events, at least under experimental conditions." | 2.42 | Safety of anti-inflammatory treatment--new ways of thinking. ( Brune, K, 2004) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "Etodolac is a new non-steroidal agent (NSAID) with anti-inflammatory and analgesic activity." | 2.37 | Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use. ( Brogden, RN; Lynch, S, 1986) |
| "Aspirin was the most frequently prescribed adjoining non-anti-hypertensive drugs (39." | 1.33 | Pattern of drug utilization among hypertensives in a Nigerian teaching hospital. ( Balogun, OB; Yusuff, KB, 2005) |
| "For acetaminophen, a small increase in overall fracture risk was observed with use within the last year (odds ratio [OR] = 1." | 1.33 | Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2006) |
| " Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity." | 1.32 | Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003) |
| "Thromboxane B2 (TXB2) was evaluated in blood on days 0, 7, and 21 of each treatment period." | 1.31 | In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. ( Budsberg, SC; Harmon, BG; Jones, CJ; Streppa, HK, 2002) |
| "Osteoarthritis is one of the oldest and most common forms of arthritis afflicting human beings." | 1.27 | Osteoarthritis. ( Brandt, KD; Eyanson, S, 1984) |
| "The term "osteoarthritis" is preferred over "osteoarthrosis." | 1.27 | Osteoarthritis in the hand. ( Swanson, AB; Swanson, GD, 1983) |
| "Aspirin has a similar effect in vivo on both atrophic cartilage and osteoarthritic cartilage in the dog, although no in vivo effect of salicylate on normal joint cartilage has been observed." | 1.27 | Nonsteroidal antiinflammatory drugs and articular cartilage. ( Brandt, KD, 1987) |
| "Indomethacin was the most common preoperative drug and the proportion of its regular use decreased from 47 to 12% (P less than 0." | 1.27 | The influence of total hip replacement on hip pain and the use of analgesics. ( Honkanen, R; Koskenvuo, M; Visuri, T, 1985) |
| "A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 micrograms/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen." | 1.27 | Aspirin dosing using 15 grain enteric coated tablets. ( Feigal, D; Jang, H; Pollet, S; White, RH; Yim, CW, 1985) |
| "Rheumatic fever is still a significant health problem in Iraq and should always be considered in the differential diagnosis of acute polyarthritis in adults." | 1.26 | Clinical features of first attack of rheumatic fever in adults. ( Al-Khateeb, N; Al-Rawi, ZS, 1982) |
| "Osteoarthritis was induced in the rabbit by a single intra-articular injection of 0." | 1.26 | Activity of anti-inflammatory drugs on an experimental model of osteoarthritis. ( Cros, J; Guiraud, R; Marcelon, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 175 (70.56) | 18.7374 |
| 1990's | 18 (7.26) | 18.2507 |
| 2000's | 37 (14.92) | 29.6817 |
| 2010's | 14 (5.65) | 24.3611 |
| 2020's | 4 (1.61) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Feng, L | 1 |
| Jia, Q | 2 |
| Xu, J | 1 |
| Wang, R | 1 |
| Wang, Z | 1 |
| Wu, Y | 1 |
| Li, Y | 1 |
| Sidhu, VS | 1 |
| Kelly, TL | 1 |
| Pratt, N | 1 |
| Graves, SE | 1 |
| Buchbinder, R | 1 |
| Adie, S | 1 |
| Cashman, K | 1 |
| Ackerman, I | 1 |
| Bastiras, D | 1 |
| Brighton, R | 1 |
| Burns, AWR | 1 |
| Chong, BH | 1 |
| Clavisi, O | 1 |
| Cripps, M | 1 |
| Dekkers, M | 1 |
| de Steiger, R | 1 |
| Dixon, M | 1 |
| Ellis, A | 1 |
| Griffith, EC | 1 |
| Hale, D | 1 |
| Hansen, A | 1 |
| Harris, A | 1 |
| Hau, R | 1 |
| Horsley, M | 1 |
| James, D | 1 |
| Khorshid, O | 1 |
| Kuo, L | 1 |
| Lewis, P | 1 |
| Lieu, D | 1 |
| Lorimer, M | 1 |
| MacDessi, S | 1 |
| McCombe, P | 1 |
| McDougall, C | 1 |
| Mulford, J | 1 |
| Naylor, JM | 1 |
| Page, RS | 1 |
| Radovanovic, J | 1 |
| Solomon, M | 1 |
| Sorial, R | 1 |
| Summersell, P | 1 |
| Tran, P | 1 |
| Walter, WL | 1 |
| Webb, S | 1 |
| Wilson, C | 1 |
| Wysocki, D | 1 |
| Harris, IA | 1 |
| Wang, X | 2 |
| Liao, H | 2 |
| Liu, Y | 2 |
| Kang, Y | 4 |
| Tu, Q | 2 |
| Li, Z | 2 |
| Sheng, P | 2 |
| Zhang, Z | 2 |
| Wei, J | 1 |
| Zeng, C | 1 |
| Lane, NE | 1 |
| Li, X | 1 |
| Lei, G | 1 |
| Zhang, Y | 1 |
| Baker, JF | 1 |
| Yeomans, ND | 2 |
| Graham, DY | 2 |
| Husni, ME | 1 |
| Solomon, DH | 1 |
| Stevens, T | 1 |
| Vargo, J | 1 |
| Wang, Q | 1 |
| Wisniewski, LM | 1 |
| Wolski, KE | 1 |
| Borer, JS | 1 |
| Libby, P | 1 |
| Lincoff, AM | 1 |
| Lüscher, TF | 1 |
| Bao, W | 1 |
| Walker, C | 1 |
| Nissen, SE | 1 |
| Hu, S | 1 |
| Belcaro, G | 1 |
| Dugall, M | 1 |
| Peterzan, P | 1 |
| Hosoi, M | 1 |
| Ledda, A | 1 |
| Riva, A | 1 |
| Giacomelli, L | 1 |
| Togni, S | 1 |
| Eggenhoffner, R | 1 |
| Cotellese, R | 1 |
| Day, RO | 1 |
| Graham, GG | 1 |
| Angiolillo, DJ | 1 |
| Datto, C | 1 |
| Raines, S | 1 |
| Temperilli, F | 1 |
| Di Franco, M | 1 |
| Massimi, I | 1 |
| Guarino, ML | 1 |
| Guzzo, MP | 1 |
| Valesini, G | 1 |
| Frati, L | 1 |
| Pulcinelli, FM | 1 |
| Meesawatsom, P | 1 |
| Burston, J | 1 |
| Hathway, G | 1 |
| Bennett, A | 1 |
| Chapman, V | 1 |
| Papich, MG | 1 |
| Renda, G | 2 |
| Zurro, M | 2 |
| Romano, M | 1 |
| De Caterina, R | 2 |
| Pillai, L | 1 |
| Levy, RM | 1 |
| Yimam, M | 1 |
| Zhao, Y | 1 |
| Burnett, BP | 1 |
| Dzielska-Olczak, M | 1 |
| Goldstein, JL | 5 |
| Chan, FK | 2 |
| Lanas, A | 1 |
| Wilcox, CM | 1 |
| Peura, D | 1 |
| Sands, GH | 1 |
| Berger, MF | 1 |
| Nguyen, H | 1 |
| Scheiman, JM | 1 |
| Gatti, D | 1 |
| Adami, S | 1 |
| Hermann, M | 1 |
| Rozin, AP | 1 |
| Toledano, K | 1 |
| Balbir-Gurman, A | 1 |
| Deeks, JJ | 1 |
| Smith, LA | 1 |
| Bradley, MD | 1 |
| Jones, CJ | 1 |
| Streppa, HK | 1 |
| Harmon, BG | 1 |
| Budsberg, SC | 2 |
| Brandt, KD | 7 |
| Lehmann, FS | 1 |
| Gyr, N | 1 |
| Chiolero, A | 1 |
| Maillard, MP | 1 |
| Burnier, M | 1 |
| GILPIN, WA | 1 |
| WILLIAMS, GT | 1 |
| WELCH, GE | 1 |
| FEINBLATT, TM | 1 |
| HART, FD | 6 |
| BOARDMAN, PL | 1 |
| SERVERDUPUY, JM | 1 |
| COPEMAN, WS | 1 |
| BOYLE, RW | 1 |
| TABET, RC | 1 |
| WIGHTMAN, BK | 1 |
| CALABRO, JJ | 4 |
| LARSON, CB | 1 |
| RUBIN, HS | 1 |
| MICHOTTE, LJ | 1 |
| WAUTERS, M | 1 |
| FUCHS, M | 1 |
| BLUMENTHAL, LS | 1 |
| Fries, JF | 1 |
| Bruce, B | 1 |
| Lisse, JR | 1 |
| Perlman, M | 1 |
| Johansson, G | 1 |
| Shoemaker, JR | 1 |
| Schechtman, J | 1 |
| Skalky, CS | 1 |
| Dixon, ME | 1 |
| Polis, AB | 1 |
| Mollen, AJ | 1 |
| Geba, GP | 1 |
| Weir, MR | 1 |
| Sperling, RS | 1 |
| Reicin, A | 1 |
| Gertz, BJ | 1 |
| Brune, K | 1 |
| Alvaro-Gracia, JM | 1 |
| Brandt, K | 1 |
| TILLIS, HH | 1 |
| CONNAMACHER, HS | 1 |
| CRAIN, DC | 1 |
| Tarone, RE | 1 |
| Lipworth, L | 1 |
| McLaughlin, JK | 1 |
| Hawkey, CJ | 1 |
| Farkouh, M | 1 |
| Gitton, X | 1 |
| Ehrsam, E | 1 |
| Huels, J | 1 |
| Richardson, P | 1 |
| Laine, L | 3 |
| Maller, ES | 1 |
| Yu, C | 1 |
| Quan, H | 1 |
| Simon, T | 1 |
| ROLLINGS, HE | 1 |
| Yusuff, KB | 1 |
| Balogun, OB | 1 |
| Bello, AE | 1 |
| Spalding, W | 1 |
| Suh, S | 1 |
| Fort, JG | 1 |
| Greenberg, JD | 2 |
| Bingham, CO | 1 |
| Abramson, SB | 2 |
| Reed, G | 1 |
| Sebaldt, RJ | 1 |
| Kremer, J | 1 |
| Eisen, GM | 1 |
| Hanna, DB | 1 |
| Rublee, DA | 1 |
| Kim, JA | 1 |
| Choi, YS | 1 |
| Kim, SH | 1 |
| Cannon, CP | 2 |
| Curtis, SP | 2 |
| Bolognese, JA | 1 |
| Vestergaard, P | 1 |
| Rejnmark, L | 1 |
| Mosekilde, L | 1 |
| Tacconelli, S | 1 |
| Capone, ML | 1 |
| Sacchetta, D | 1 |
| Santarelli, F | 1 |
| Sciulli, MG | 1 |
| Zimarino, M | 1 |
| Grana, M | 1 |
| D'Amelio, E | 1 |
| Price, TS | 1 |
| Patrono, C | 1 |
| Patrignani, P | 1 |
| Cryer, B | 2 |
| Kaur, A | 1 |
| Brainard, BM | 1 |
| Meredith, CP | 1 |
| Callan, MB | 1 |
| Shofer, FS | 1 |
| Driessen, B | 1 |
| Otto, CM | 1 |
| Farkouh, ME | 1 |
| Jeger, RV | 1 |
| Ramanathan, K | 1 |
| Verheugt, FW | 1 |
| Chesebro, JH | 1 |
| Kirshner, H | 1 |
| Hochman, JS | 1 |
| Lay, CL | 1 |
| Ruland, S | 1 |
| Mellein, B | 1 |
| Matchaba, PT | 1 |
| Fuster, V | 1 |
| Nakamura, T | 1 |
| Shi, D | 1 |
| Tzetis, M | 1 |
| Rodriguez-Lopez, J | 1 |
| Miyamoto, Y | 1 |
| Tsezou, A | 1 |
| Gonzalez, A | 1 |
| Jiang, Q | 1 |
| Kamatani, N | 1 |
| Loughlin, J | 1 |
| Ikegawa, S | 1 |
| Benito-Garcia, E | 1 |
| Michaud, K | 1 |
| Wolfe, F | 1 |
| Amer, F | 1 |
| Hunt, B | 1 |
| Simon, LS | 3 |
| Vanselow, NA | 1 |
| Smith, JR | 1 |
| Kantor, TG | 1 |
| Lussier, A | 2 |
| Elie, R | 1 |
| Gareau, J | 1 |
| Andelman, SY | 1 |
| Caldwell, JR | 2 |
| Crain, D | 1 |
| Hoffmeister, RT | 1 |
| Kantrowitz, F | 1 |
| Lloyd, RJ | 1 |
| Nussdorf, RT | 1 |
| Schmid, FR | 1 |
| Repice, MR | 1 |
| Gordon, GV | 1 |
| Zizic, TM | 1 |
| Stevens, MB | 1 |
| Sutton, JD | 1 |
| Pinals, RS | 1 |
| Bernstein, J | 1 |
| Willkens, RF | 2 |
| Perlík, F | 1 |
| Altman, RD | 1 |
| Hochberg, MC | 1 |
| Guobis, G | 1 |
| Iushenaite, Ia | 1 |
| Palmoski, MJ | 3 |
| Calin, A | 1 |
| Eyanson, S | 1 |
| Swanson, AB | 1 |
| Swanson, GD | 1 |
| Brogden, RN | 3 |
| Heel, RC | 1 |
| Pakes, GE | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Spruill, WJ | 1 |
| Cooper, JW | 1 |
| Neubauer, M | 2 |
| Bach, GL | 3 |
| Mikulaschek, WM | 2 |
| Alarcon-Segovia, D | 1 |
| Huskisson, EC | 6 |
| Balme, HW | 1 |
| Wojtulewski, JA | 1 |
| Loizzi, P | 1 |
| Caroli, A | 1 |
| Dieppe, P | 1 |
| Doyle, D | 1 |
| Jacoby, R | 1 |
| Katona, G | 2 |
| Rubegni, M | 1 |
| Sacchetti, G | 1 |
| Bruni, G | 1 |
| De Mauro, G | 1 |
| Provvedi, D | 1 |
| Valtonen, E | 1 |
| Bergamini, N | 1 |
| Groppi, W | 1 |
| Mandelli, V | 1 |
| Seigel, D | 1 |
| Sperduto, RD | 1 |
| Ferris, FL | 1 |
| Al-Rawi, ZS | 1 |
| Al-Khateeb, N | 1 |
| Serup, J | 1 |
| Ovesen, JO | 1 |
| Spiegel, TM | 1 |
| Weiss, J | 1 |
| Cotlier, E | 1 |
| Colyer, RA | 1 |
| Caruso, I | 1 |
| Bianchi Porro, G | 1 |
| Gross, D | 1 |
| Frei, M | 1 |
| Rau, R | 1 |
| Boussina, J | 1 |
| Kuo, SY | 1 |
| Chu, SJ | 1 |
| Hsu, CM | 1 |
| Chen, CM | 1 |
| Chang, ML | 1 |
| Chang, DM | 1 |
| Manicourt, DH | 1 |
| Druetz-Van Egeren, A | 1 |
| Haazen, L | 1 |
| Nagant de Deuxchaisnes, C | 1 |
| Douglas, DM | 1 |
| Ward, L | 1 |
| Brown, JS | 1 |
| Murtaugh, RJ | 1 |
| Matz, ME | 1 |
| Labato, MA | 1 |
| Boudrieau, RJ | 1 |
| Furst, DE | 1 |
| Anderson, W | 1 |
| Westrich, GH | 1 |
| Sculco, TP | 1 |
| Fox, SM | 1 |
| Johnston, SA | 1 |
| Vane, JR | 1 |
| Botting, RM | 1 |
| Hardie, EM | 1 |
| Castor, CW | 1 |
| Smith, EM | 1 |
| Bignall, MC | 1 |
| Hossler, PA | 1 |
| Eccles, M | 1 |
| Freemantle, N | 1 |
| Mason, J | 1 |
| Lanza, FL | 1 |
| Lipsky, PE | 1 |
| Hubbard, RC | 1 |
| Talwalker, S | 1 |
| Schwartz, BD | 1 |
| Isakson, PC | 1 |
| Geis, GS | 2 |
| Nurmohamed, MT | 1 |
| Lems, WF | 1 |
| Dijkmans, BA | 1 |
| Silverstein, FE | 1 |
| Faich, G | 1 |
| Pincus, T | 1 |
| Whelton, A | 1 |
| Makuch, R | 1 |
| Eisen, G | 1 |
| Agrawal, NM | 1 |
| Stenson, WF | 1 |
| Burr, AM | 1 |
| Zhao, WW | 1 |
| Kent, JD | 1 |
| Lefkowith, JB | 1 |
| Verburg, KM | 1 |
| Visser, LE | 1 |
| Graatsma, HH | 1 |
| Stricker, BH | 1 |
| Crofford, LJ | 1 |
| Ausiello, JC | 1 |
| Stafford, RS | 1 |
| Oyemade, GA | 1 |
| Onadeko, BO | 1 |
| Robinson, DR | 1 |
| McGuire, MB | 1 |
| Levine, L | 1 |
| Lewis, JR | 2 |
| Engbaek, J | 1 |
| Ehrlich, GE | 2 |
| Giansiracusa, JE | 1 |
| Donaldson, MS | 1 |
| Koonce, ML | 1 |
| Lefton, TE | 1 |
| Ruoff, GE | 1 |
| Brooks, CD | 3 |
| Müller, FO | 2 |
| Gosling, JA | 1 |
| Erdmann, GH | 1 |
| Andrew, A | 1 |
| Rodda, B | 1 |
| Verhaest, L | 1 |
| Van Winzum, C | 1 |
| Astorga, G | 1 |
| Bedoya, J | 1 |
| Debolini, A | 1 |
| Marcolongo, R | 2 |
| Granelli, G | 1 |
| Scott, J | 1 |
| Liyanage, SP | 1 |
| Tambar, PK | 1 |
| Grayson, MF | 2 |
| Hicklin, JA | 1 |
| Dieppe, PA | 2 |
| Melton, JW | 1 |
| Ward, JR | 2 |
| Neustadt, D | 1 |
| Multz, C | 1 |
| Valtonen, EJ | 1 |
| Moskowitz, RW | 1 |
| Wilhelmi, G | 1 |
| Tanaka, S | 1 |
| Ito, T | 1 |
| Mori, E | 1 |
| Muroga, T | 1 |
| Nakajima, A | 1 |
| Diamond, HS | 1 |
| Brooke, JW | 1 |
| McMahon, FG | 2 |
| Jain, A | 1 |
| Onel, A | 1 |
| Sack, KE | 1 |
| Rosenthal, SH | 1 |
| Melluish, JW | 1 |
| Ruoff, G | 1 |
| Cross, CJ | 1 |
| Sanborn, EC | 1 |
| Soren, A | 3 |
| Feinstein, PA | 1 |
| Habermann, ET | 1 |
| Clarke, AK | 1 |
| Meyrick, RL | 1 |
| Monson, RR | 1 |
| Hall, AP | 1 |
| Marcelon, G | 1 |
| Cros, J | 1 |
| Guiraud, R | 1 |
| Weiss, TE | 1 |
| Gum, OB | 1 |
| Biundo, JJ | 1 |
| Kolodny, AL | 1 |
| Klipper, AR | 1 |
| Soreff, J | 1 |
| Johnsson, H | 1 |
| Diener, L | 1 |
| Göransson, L | 1 |
| McBeath, AA | 1 |
| Mason, DI | 1 |
| Brooks, PM | 1 |
| Buchanan, WW | 3 |
| Adamska-Dyniewska, H | 1 |
| Goch, JH | 1 |
| Bala, T | 1 |
| Chojnacki, J | 1 |
| Chojnowska-Jezierska, J | 1 |
| Tkaczewski, W | 1 |
| Levy, NS | 1 |
| Hanscom, T | 1 |
| Haslock, I | 2 |
| Omar, AS | 1 |
| Wright, V | 2 |
| Fleischmann, RM | 1 |
| Puccetti, G | 1 |
| Galassi, A | 1 |
| Gigli, P | 1 |
| Pierallini, FM | 1 |
| Pieraccini, A | 1 |
| Scalabrino, A | 1 |
| Pagnani, MJ | 1 |
| Pellicci, PM | 1 |
| Salvati, EA | 2 |
| Euler, AR | 1 |
| Safdi, M | 1 |
| Rao, J | 1 |
| Jaszewski, R | 2 |
| Welsh, J | 1 |
| Le, V | 1 |
| Raskin, J | 1 |
| Fleischmann, R | 1 |
| Razzaque, M | 1 |
| Champion, C | 1 |
| Linet, OI | 1 |
| Schellenberg, D | 1 |
| Turner, LF | 3 |
| Defesche, CL | 1 |
| Teoh, KW | 1 |
| Johnson, JH | 1 |
| Assenzo, JR | 1 |
| Calzada, R | 1 |
| Dhar, R | 1 |
| Taylor, J | 1 |
| Krondl, M | 1 |
| Rao, V | 1 |
| Lynch, NM | 1 |
| McHutchison, JG | 1 |
| Young, GP | 1 |
| Deacon, M | 1 |
| St John, DJ | 1 |
| Barraclough, D | 1 |
| Shand, DG | 1 |
| Epstein, C | 1 |
| Kinberg-Calhoun, J | 1 |
| Mullane, JF | 1 |
| Sanda, M | 1 |
| Lynch, S | 1 |
| Ryan, JR | 1 |
| Vargas, R | 1 |
| Clay, GA | 1 |
| Kerzberg, EM | 1 |
| Roldán, EJ | 1 |
| Castelli, G | 1 |
| Huberman, ED | 1 |
| Mullen, BJ | 2 |
| Appelrouth, DJ | 1 |
| Baim, S | 1 |
| Chang, RW | 1 |
| Cohen, MH | 1 |
| Englund, DW | 1 |
| Germain, BF | 1 |
| Hartman, SS | 1 |
| Jaffer, A | 1 |
| Smith, FE | 1 |
| Zide, MF | 1 |
| Carlton, DM | 1 |
| Kent, JN | 1 |
| Altman, R | 1 |
| Bonney, SL | 1 |
| Northington, RS | 1 |
| Hedrich, DA | 1 |
| Walker, BR | 1 |
| Visuri, T | 1 |
| Koskenvuo, M | 1 |
| Honkanen, R | 1 |
| Sorkin, EM | 1 |
| Londino, AV | 1 |
| Giordano, N | 1 |
| Bassi, GP | 1 |
| Giannini, R | 1 |
| Borghi, C | 1 |
| Francucci, BM | 1 |
| Camarri, E | 1 |
| Mordini, M | 1 |
| Cocco, F | 1 |
| Neri, D | 1 |
| Quinet, RJ | 1 |
| Lomen, PL | 2 |
| Lamborn, KR | 2 |
| Porter, GH | 1 |
| Brinn, EL | 1 |
| Pollet, S | 1 |
| White, RH | 1 |
| Jang, H | 1 |
| Yim, CW | 1 |
| Feigal, D | 1 |
| Macauley, D | 1 |
| Dalessio, DJ | 1 |
| Scharff, EU | 1 |
| Brühl, W | 1 |
| Anastassiades, TP | 1 |
| Aglietti, P | 1 |
| Mendes, DG | 1 |
| Wilson, PD | 1 |
| Ennis, RS | 1 |
| Granda, JL | 1 |
| Posner, AS | 1 |
| Vasilenko, VKh | 1 |
| Tsodikov, GV | 1 |
| Minushkin, ON | 1 |
| Lazansky, MG | 1 |
| Cosh, JA | 1 |
| Treadwell, BL | 1 |
| Carroll, DG | 1 |
| Pomare, EW | 1 |
| Phillips, J | 1 |
| Rogerson, R | 1 |
| Bottici, R | 1 |
| Ferrucci, A | 1 |
| Taddeucci, E | 1 |
| DuVal, MK | 1 |
| Zachariae, E | 1 |
| Sylvest, J | 1 |
| Maneksha, S | 1 |
| Chrisman, OD | 1 |
| Snook, GA | 1 |
| Joubert, PH | 1 |
| Kushlick, AR | 1 |
| McNeill, WG | 1 |
| Sheard, ES | 1 |
| Solomon, L | 1 |
| Abrams, G | 1 |
| Brocks, BE | 1 |
| Harth, M | 1 |
| Bondy, DC | 1 |
| Lewis-Faning, E | 1 |
| Fowler, PD | 1 |
| Shenfield, GM | 1 |
| Taylor, RT | 1 |
| Denko, CW | 1 |
| DeFelice, EA | 1 |
| Shaffer, J | 1 |
| Dick, WC | 2 |
| Collins, KE | 1 |
| Grossi, F | 1 |
| Grassi, M | 1 |
| Hardin, JG | 1 |
| Tudhope, GR | 1 |
| Viara, M | 1 |
| Thorpe, P | 1 |
| Asai, H | 1 |
| Nakamura, R | 1 |
| Nuki, G | 1 |
| Whaley, K | 1 |
| Deodhar, S | 1 |
| Ammitzboll, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploring the Health Benefits Associated With Daily Pulse Consumption in Individuals With Peripheral Arterial Disease[NCT00755677] | Early Phase 1 | 26 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744] | 101 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| A Randomized, Double-Blind, Multicenter Study to Evaluate the Tolerability and Effectiveness of Etoricoxib 90 mg q.d. vs. Diclofenac Sodium 50 mg t.i.d. in Patients With Osteoarthritis[NCT00092703] | Phase 3 | 6,000 participants | Interventional | 2002-06-27 | Completed | ||
| A 12-Week, Randomized, Placebo- and Active-Comparator-Controlled, Parallel-Group, Double-Blind Study to Assess the Safety and Efficacy of Etoricoxib 30 mg Versus Ibuprofen 2400 mg in Patients With Osteoarthritis (Study 1)[NCT00269191] | Phase 3 | 528 participants (Actual) | Interventional | 2003-02-05 | Completed | ||
| A Randomized, Double-Blind, Active-Comparator-Controlled, Parallel-Group Study to Evaluate the Safety of Etoricoxib in Patients With Osteoarthritis or Rheumatoid Arthritis[NCT00250445] | Phase 3 | 23,498 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| A Randomized, Double-Blind, Phase 3 Study to Compare the Efficacy and Safety of Lansoprazole 30 mg QD and Naproxen 500 mg BID Versus Celecoxib 200 mg QD in Risk Reduction of Non Steroidal Anti-Inflammatory-Associated Ulcers in Osteoarthritis Subjects Taki[NCT00175032] | Phase 3 | 1,045 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery[NCT02684851] | Phase 3 | 87 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| In Vivo Selectivity of Cyclooxygenase Inhibitors in the Oral Surgery Model[NCT00006299] | Phase 2 | 120 participants | Interventional | 1999-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month
| Intervention | participants (Number) |
|---|---|
| Proton Pump Inhibitor Group | 1 |
| Histamine-2 Receptor Antagonist Group | 7 |
Number of participant received allogenic blood transfusions. (NCT02684851)
Timeframe: post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Tranexamic | 21 |
| Placebo | 13 |
To measure average estimate perioperative blood loss (NCT02684851)
Timeframe: perioperative
| Intervention | mL (Mean) |
|---|---|
| Tranexamic | 727.6 |
| Placebo | 560.1 |
Do patients undergoing acetabular ORIF who receive tranexamic acid have a higher risk for thromboembolic events than patients who receive placebo? (NCT02684851)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Tranexamic | 1 |
| Placebo | 0 |
Average units packed red blood cells transfused among participants (NCT02684851)
Timeframe: perioperative
| Intervention | Units of packed red blood cells (Mean) |
|---|---|
| Tranexamic | 2.65 |
| Placebo | 2.36 |
37 reviews available for aspirin and Osteoarthritis
| Article | Year |
|---|---|
An update on nonsteroidal anti-inflammatory drugs (NSAIDs) in small animals.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cat Diseases; Cats; Dog Diseases; Dogs; D | 2008 |
[Cyclooxygenases inhibitors and other compounds with antiinflammatory potential in osteoarthrosis--part II].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyclooxygenase Inhibitors; Drug Interactions; Humans; Na | 2011 |
Coxibs: a significant therapeutic opportunity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Interactions; Et | 2010 |
[Cardiovascular risk of non-steroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cardiovascular Diseases; Cy | 2012 |
Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase I | 2002 |
[The future of peptic ulcer disease without Helicobacter].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin | 2003 |
Cardiovascular hazard of selective COX-2 inhibitors: myth or reality?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cardiovascular Diseases; Ce | 2002 |
Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood | 2003 |
Safety of anti-inflammatory treatment--new ways of thinking.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cycl | 2004 |
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Topics: Acetates; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 2004 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis.
Topics: Abdominal Pain; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumat | 2005 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Cyclooxyge | 2007 |
Meta-analysis of association between the ASPN D-repeat and osteoarthritis.
Topics: Alleles; Aspirin; Body Mass Index; Extracellular Matrix Proteins; Female; Genotype; Hip; Humans; Kne | 2007 |
The COX 2 selective inhibitors: what the newspapers have not told you.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthritis, Rheumatoid; Aspirin; Blood Press | 2007 |
Approaches to rheumatoid arthritis and osteoarthritis: an overview.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Clinical Trials as Topic; | 1983 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofena | 1981 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
Differential effects of diclofenac and aspirin on serum glutamic oxaloacetic transaminase elevations in patients with rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspirin; Diclofenac; Humans; Osteoarthritis | 1993 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Mechanism of action of aspirin-like drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase 1; | 1997 |
Management of osteoarthritis in cats.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 1997 |
Risk of post-discharge venous thromboembolism in patients with rheumatoid arthritis undergoing knee or hip arthroplasty. Is prolonged thromboprophylaxis warranted or dangerous?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Arthroplasty, Replacement; Arthropla | 1999 |
Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use?
Topics: Arthritis; Aspirin; Cardiovascular System; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2002 |
Rheumatoid arthritis: an overview.
Topics: Adult; Arthritis; Arthritis, Reactive; Arthritis, Rheumatoid; Aspirin; Diagnosis, Differential; Fema | 1976 |
Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Etodolac; Humans; | 1986 |
Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Drug Evalu | 1985 |
Animal models of osteoarthritis: implication for pathogenesis and treatment.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Disease Models, An | 1985 |
[Pathophysiological basis for the treatment of degenerative joint diseases].
Topics: Aspirin; Back Pain; Body Weight; Diagnosis, Differential; Humans; Mucopolysaccharidosis IV; Osteoart | 1973 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
Medical management of the patient with arthritis.
Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Infectious; Arthritis, Rheumatoid; Aspirin; Chond | 1974 |
Arthritis and the working man: hope through research.
Topics: Animals; Arthritis; Arthritis, Infectious; Arthritis, Rheumatoid; Aspirin; Cyclophosphamide; Disease | 1973 |
The role of patelloplasty and patellectomy in the arthritic knee.
Topics: Arthroplasty; Aspirin; Cathepsins; Debridement; Humans; Joint Dislocations; Joint Prosthesis; Knee; | 1974 |
The gut and arthritis.
Topics: Adrenal Cortex Hormones; Analgesics; Anti-Inflammatory Agents; Arthritis, Infectious; Arthritis, Rhe | 1974 |
Ibuprofen. A review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials | 1971 |
Rheumatoid arthritis. A potentially crippling disease that may attack at any age.
Topics: Adrenal Cortex Hormones; Agammaglobulinemia; Age Factors; Analgesics; Antimalarials; Arthritis, Juve | 1971 |
102 trials available for aspirin and Osteoarthritis
| Article | Year |
|---|---|
Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial.
Topics: Aged; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Aspirin; Aust | 2022 |
Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspi | 2018 |
Impact of concomitant low-dose aspirin on the safety and tolerability of naproxen and esomeprazole magnesium delayed-release tablets in patients requiring chronic nonsteroidal anti-inflammatory drug therapy: an analysis from 5 Phase III studies.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid | 2014 |
Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors.
Topics: Aged; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Humans; Ibuprofen; | 2010 |
Flavocoxid, an anti-inflammatory agent of botanical origin, does not affect coagulation or interact with anticoagulation therapies.
Topics: Adult; Aged; Animals; Anticoagulants; Arachidonate 5-Lipoxygenase; Aspirin; Bleeding Time; Catechin; | 2010 |
Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials.
Topics: Adult; Aged; Anemia; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Celeco | 2011 |
Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors | 2003 |
Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 In | 2004 |
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2004 |
Cyclooxygenase-2 specific inhibitors and upper gastrointestinal tolerability in patients with osteoarthritis receiving concomitant low dose aspirin: pooled analysis of 2 trials.
Topics: Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method | 2005 |
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Celecoxib; Double-Blind Method; Drug Adminis | 2006 |
Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs.
Topics: Animals; Aspirin; Carbazoles; Cross-Over Studies; Cyclooxygenase Inhibitors; Dog Diseases; Dogs; Fem | 2007 |
Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 In | 2007 |
The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestinal ulcers associated to cyclooxygenase-2 selective inhibitors.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase 2 Inhi | 2007 |
Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas | 2007 |
A placebo-controlled trial of floctafenine (idarac) against enteric-coated acetylsalicylic acid in osteoarthritic patients.
Topics: Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; ortho-Ami | 1980 |
Etodolac, aspirin, and placebo in patients with degenerative joint disease: a twelve-week study.
Topics: Acetates; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Double-Blind Met | 1983 |
Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Fenopro | 1983 |
Piroxicam vs. aspirin and indomethacin: efficacy, safety, and compliance in osteoarthritis and rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Met | 1983 |
Piroxicam in osteoarthritis: a controlled long-term study.
Topics: Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Longitudinal Studies; | 1983 |
Approaches to rheumatoid arthritis and osteoarthritis: an overview.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Clinical Trials as Topic; | 1983 |
Overview of efficacy of fenbufen in rheumatoid arthritis and osteoarthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Humans; Indometh | 1983 |
Long-term clinical evaluation of suprofen and aspirin in patients with osteoarthritis.
Topics: Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteoarth | 1983 |
[Clinical evaluation of analgesics].
Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Comb | 1984 |
Review of ibuprofen for osteoarthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Diflunisal; Drug Toleran | 1984 |
[Pharmacodynamics and adverse effects of modern nonsteroid anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofena | 1981 |
[Short-term therapy of painful muscular disorders. Results of a multicenter double-blind test of 2 new suppository preparations with and without codeine].
Topics: Arthritis; Aspirin; Clinical Trials as Topic; Codeine; Diphenhydramine; Double-Blind Method; Drug Co | 1983 |
Long-term safety of benoxaprofen.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Blood Urea Nitrogen; C | 1980 |
Long-term treatment of symptomatic osteoarthritis with benoxaprofen. Double-blind comparison with aspirin and ibuprofen.
Topics: Adult; Aged; Anti-Inflammatory Agents; Aspirin; Benzoxazoles; Clinical Trials as Topic; Double-Blind | 1980 |
[Experience with sulindac in rheumatoid arthritis and osteoarthritis].
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Humans; Indenes; Osteoarthritis; Placebos; | 1980 |
Clinical experience with tolmetin sodium.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Fibro | 1980 |
[A new non-steroid anti-inflammatory agent in therapy of osteoarthrosis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Bufexamac; Clinical Trials as Topic; Female; Humans; Hy | 1980 |
Meclofenamate sodium (meclomen) a new antiarthritic agent.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Humans; Indomethacin; Meclofenamic Acid; o | 1980 |
[Double-blind study of SAMe (capsules) and aspirin in osteoarthrosis].
Topics: Adult; Aged; Aspirin; Capsules; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; | 1980 |
Arthritis: anti-inflammatory drugs in practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Arthritis, Rheumatoid; As | 1981 |
Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blin | 1981 |
A double-blind evaluation of oral indoprofen versus ASA in osteoarthritic patients: influence on haemostatic parameters and clinical effects.
Topics: Adult; Aged; Aspirin; Bleeding Time; Clinical Trials as Topic; Double-Blind Method; Female; Heartbur | 1981 |
Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis.
Topics: Aged; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Fema | 1981 |
Activated osteoarthrosis (osteoarthritis) and its treatment with indomethacin and benoxaprofen: a double-blind crossover study.
Topics: Adult; Aged; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Double-Blind Method; Femal | 1982 |
[Diflunisal in the treatment of coxarthrosis and gonarthrosis. A comparative double-blind study with acetylsalicylic acid].
Topics: Adult; Aged; Aspirin; Diflunisal; Double-Blind Method; Drug Evaluation; Female; Hip; Humans; Knee; M | 1980 |
Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs.
Topics: Animals; Aspirin; Diarrhea; Dog Diseases; Dogs; Double-Blind Method; Duodenoscopy; Female; Gastroint | 1993 |
Differential effects of diclofenac and aspirin on serum glutamic oxaloacetic transaminase elevations in patients with rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspirin; Diclofenac; Humans; Osteoarthritis | 1993 |
Prophylaxis against deep venous thrombosis after total knee arthroplasty. Pneumatic plantar compression and aspirin compared with aspirin alone.
Topics: Arthritis, Rheumatoid; Aspirin; Bandages; Combined Modality Therapy; Female; Foot; Humans; Joint Pro | 1996 |
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase Inhibitors | 1998 |
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2000 |
A controlled clinical study comparing sulindac with ibuprofen and aspirin in the treatment of musculo-skeletal diseases.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; | 1979 |
Ibuprofen in osteoarthritis.
Topics: Activities of Daily Living; Aspirin; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Dextro | 1977 |
A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee.
Topics: Aspirin; Clinical Trials as Topic; Humans; Knee Joint; Osteoarthritis; Pyrroles; Tolmetin | 1977 |
Diflunisal: six-month experience in osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Drug Evaluation; Fluorob | 1977 |
[A comparison of fenbufen and acetyl-salicylic acid in the treatment of osteoarthritis (author's transl)].
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Drug Evaluation; Humans; Middle A | 1977 |
[Comparison of tolerability and clinical efficacy of acetylsalicylic acid and a new nonsteroid anti-inflammatory drug in osteoarthritis].
Topics: Adult; Animals; Aspirin; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Hydroxamic Acids; | 1977 |
Sulindac. Trials of a new anti-inflammatory drug.
Topics: Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Clinical Trials as Topic; Double-Blind Method | 1978 |
Comparative study of salsalate and aspirin in osteoarthrosis of the hip or knee.
Topics: Acetaminophen; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; | 1978 |
Two trials of diflunisal in osteoarthritis.
Topics: Aged; Analgesics; Aspirin; Biphenyl Compounds; Clinical Trials as Topic; Double-Blind Method; Female | 1978 |
Relationship of plasma salicylate levels to pain relief with two different salicylates.
Topics: Analgesics; Aspirin; Biphenyl Compounds; Clinical Trials as Topic; Humans; Occult Blood; Osteoarthri | 1978 |
A clinical trial of diflunisal against aspirin in osteoarthritis.
Topics: Abdomen; Aspirin; Clinical Trials as Topic; Dizziness; Double-Blind Method; Drug Administration Sche | 1978 |
Diflunisal and aspirin: a comparison of efficacy and nephrotoxicity in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blin | 1979 |
Naproxen vs. aspirin in osteoarthritis of the hip and knee.
Topics: Adult; Aged; Aspirin; Central Nervous System Diseases; Clinical Trials as Topic; Double-Blind Method | 1978 |
Clinical comparison of fenbufen and aspirin in osteoarthritis.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biphenyl Compounds; C | 1979 |
Double-blind study of Naproxen in osteoarthritis of the knee joint.
Topics: Activities of Daily Living; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; C | 1976 |
Double-blind crossover study of fenoprofen and aspirin in osteoarthritis.
Topics: Aged; Aspirin; Clinical Trials as Topic; Female; Fenoprofen; Humans; Male; Middle Aged; Osteoarthrit | 1976 |
Fenoprofen therapy in large-joint osteoarthritis: double-blind comparison with aspirin and longterm experience.
Topics: Aged; Aspirin; Clinical Trials as Topic; Female; Fenoprofen; Humans; Male; Middle Aged; Osteoarthrit | 1976 |
Controlled evaluation of fenoprofen in geriatric patients with osteoarthritis.
Topics: Aged; Aspirin; Clinical Trials as Topic; Female; Fenoprofen; Humans; Male; Middle Aged; Osteoarthrit | 1976 |
Phenylbutazone and aspirin in osteoarthritis: a controlled study.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; | 1975 |
Clinical and objective assessments of naproxen through 5 years of clinical experience.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Chronic Disease; C | 1975 |
Ibuprofen and visual function. Prospective evaluation.
Topics: Adult; Aged; Aspirin; Female; Humans; Ibuprofen; Long-Term Care; Male; Middle Aged; Osteoarthritis; | 1975 |
Acetylsalicylic acid in a trial to diminish thromboembolic complications after elective hip surgery.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Female; Hip; Humans; Male; Middle Aged; Osteoarthrit | 1975 |
Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis.
Topics: Adult; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Butanon | 1992 |
[Iontophoresis of tenoxicam in the therapy of osteoarthrosis].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Iontophoresis; Male; Middle | 1992 |
A report of three multiclinic trials evaluating arbaprostil in arthritic patients with ASA/NSAID gastric mucosal damage. The Upjohn Company Arbaprostil ASA/NSAID Gastric Mucosal Damage Treatment Study Groups.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aluminum Hydroxide; Anti-Inflammatory Agents, | 1990 |
Clinical safety of flurbiprofen.
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Digestive System; Female; Flurbipro | 1990 |
Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin.
Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cimetidine; Drug Therapy, Combination; G | 1989 |
Acetylsalicylic acid dose fails to affect energy intake of osteoarthritic elderly.
Topics: Aged; Aspirin; Energy Intake; Humans; Osteoarthritis | 1989 |
Gastrointestinal blood loss from a new buffered aspirin (Ostoprin): measurement by radiochromium and Hemoquant techniques.
Topics: Adolescent; Adult; Aged; Aspirin; Chromium Radioisotopes; Female; Gastrointestinal Hemorrhage; Heme; | 1989 |
The effect of etodolac administration on renal function in patients with arthritis.
Topics: Acetates; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Urea | 1986 |
Role of misoprostol in reducing aspirin-induced gastrointestinal blood loss in arthritic patients.
Topics: Alprostadil; Anti-Ulcer Agents; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle A | 1987 |
Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthrosis.
Topics: Aspirin; Chondroitin Sulfates; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; | 1987 |
Results of a six-month study comparing the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Clinical Trials as Topic; | 1987 |
Comparison of the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis in adults.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Clinical Trials as Topic; | 1987 |
International experiences with diclofenac in osteoarthritis.
Topics: Aspirin; Clinical Trials as Topic; Diclofenac; Diflunisal; Double-Blind Method; Gastrointestinal Dis | 1986 |
Efficacy of diclofenac in osteoarthritis. Experience in the United States.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Hip Joint; Humans; | 1986 |
Renal safety of two analgesics used over the counter: ibuprofen and aspirin.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Blood Urea Nitrogen; Clinical Trials as Topic; Creatini | 1986 |
Clinical perspectives in rheumatology: a review of three common forms of arthritis and results of United States trials with isoxicam.
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Bl | 1985 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration | 1985 |
Worldwide clinical safety experience with diclofenac.
Topics: Aspirin; Clinical Trials as Topic; Diclofenac; France; Humans; Ibuprofen; Japan; Osteoarthritis; Rhe | 1985 |
Treatment of osteoarthritis of the knee. A comparison of flurbiprofen and aspirin.
Topics: Adult; Aged; Aspirin; Drug Evaluation; Female; Flurbiprofen; Humans; Knee Joint; Male; Middle Aged; | 1986 |
A double-blind comparison of phenylbutazone and aspirin in osteoarthritis.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Osteoarthritis; P | 1974 |
[Thromboembolic complications following total hip prosthesis. Study of 478 cases of relative efficacy of 3 preventive methods].
Topics: Anticoagulants; Aspirin; Clinical Trials as Topic; Dextrans; Drug Evaluation; Drug Therapy, Combinat | 1974 |
A double-blind comparative trial of aspirin preparation and ibuprofen in general practice.
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Fami | 1972 |
[First results of the clinical use of injectable lysine acetylsalicylate].
Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations | 1972 |
Osteoarthritis of the knee treated with tolfenamic acid.
Topics: Adult; Aged; Alanine Transaminase; Aspirin; Body Weight; Clinical Trials as Topic; Creatinine; Femal | 1972 |
'Safapryn' and benorylate--a comparative trial of two new preparations of aspirin and paracetamol in the treatment of rheumatoid arthritis and osteoarthritis.
Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations; Drug Eva | 1973 |
South African multicentre trial with Voltaren in osteo-arthritis of the knee.
Topics: Analgesics; Aniline Compounds; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Ethnicit | 1974 |
Orudis in the management of osteo-arthritis of the knee. A double-blind trial.
Topics: Acetaminophen; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; | 1974 |
Fenoprofen.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Fenoprofen; Humans; Male; Osteoarthritis; | 1974 |
A comparison of flufenamic acid and phenylbutazone in osteoarthritis of the hip.
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Blood Sedimentation; Body Weight; Clinical Trials as Topic; | 1966 |
Indomethacin and acetylsalicylic acid in the treatment of osteoarthritis of the hips and knees.
Topics: Aged; Aspirin; Clinical Trials as Topic; Hip Joint; Humans; Indomethacin; Knee Joint; Male; Middle A | 1969 |
Drug treatment of rheumatic disorders in general practice. A comparative study of aspirin and an alkali-phenylbutazone preparation.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Family Practice; Female; Humans; Male; Mid | 1971 |
Ibuprofen. A review.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials | 1971 |
Namoxyrate in rheumatic disorders.
Topics: Aged; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Butyrates; Clinical Tria | 1965 |
An assessment of "Fiorinal" and FIPA in painful conditions of the hands.
Topics: Acetaminophen; Adult; Aged; Analgesics; Analysis of Variance; Arthritis, Rheumatoid; Aspirin; Caffei | 1970 |
Effect of non-steroidal anti-inflammatory drugs on osteoarthritis of the knee. With special reference to PSP clearance as an indicator.
Topics: Aspirin; Humans; Indomethacin; Inflammation; Knee Joint; Osteoarthritis; Phenylbutazone; Physical Th | 1970 |
114 other studies available for aspirin and Osteoarthritis
| Article | Year |
|---|---|
Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.
Topics: Animals; beta-Glucosidase; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2011 |
Aspirin reverses inflammatory suppression of chondrogenesis by stabilizing YAP.
Topics: Animals; Aspirin; Cell Differentiation; Cells, Cultured; Chondrogenesis; Mesenchymal Stem Cells; Mic | 2023 |
Aspirin reverses inflammatory suppression of chondrogenesis by stabilizing YAP.
Topics: Animals; Aspirin; Cell Differentiation; Cells, Cultured; Chondrogenesis; Mesenchymal Stem Cells; Mic | 2023 |
Aspirin reverses inflammatory suppression of chondrogenesis by stabilizing YAP.
Topics: Animals; Aspirin; Cell Differentiation; Cells, Cultured; Chondrogenesis; Mesenchymal Stem Cells; Mic | 2023 |
Aspirin reverses inflammatory suppression of chondrogenesis by stabilizing YAP.
Topics: Animals; Aspirin; Cell Differentiation; Cells, Cultured; Chondrogenesis; Mesenchymal Stem Cells; Mic | 2023 |
Interactions of Nonsteroidal Antiinflammatory Drugs and Aspirin and Risk of Cardiovascular Disease in Patients With Osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Humans; Ibuprofen; Naprox | 2023 |
Invited Commentary: A Step Toward Safer and More Precise Management of Osteoarthritis Pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Osteoarthritis; Pain | 2023 |
Interaction study between antiplatelet agents, anticoagulants, thyroid replacement therapy and a bioavailable formulation of curcumin (Meriva®).
Topics: Anticoagulants; Aspirin; Blood Glucose; Clopidogrel; Curcumin; Drug Compounding; Drug Interactions; | 2018 |
Non-steroidal anti-inflammatory drugs (NSAIDs).
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; As | 2013 |
Nonsteroidal anti-inflammatory drugs in-vitro and in-vivo treatment and Multidrug Resistance Protein 4 expression in human platelets.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Case-Control Studies | 2016 |
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo | 2016 |
The dancing hare (Milwaukee hematoma).
Topics: Aged; Aspirin; Betamethasone; Calcinosis; Colchicine; Glucocorticoids; Hematoma; Humans; Male; Osteo | 2012 |
[Coxib spares the stomach. This is true also for patients with preventive aspirin administration].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Celecoxib; Drug Therapy, Co | 2002 |
In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs.
Topics: Animals; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dog | 2002 |
Key questions concerning paracetamol and NSAIDs for OA.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; I | 2003 |
Treatment of rheumatoid arthritis and osteoarthritis with succinate-salicylate.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Humans; Osteoarthritis; Salicylates; Succinates; Succinic | 1955 |
A controlled study of prednisone, aspirin and a placebo in degenerative joint disease.
Topics: Aspirin; Humans; Osteoarthritis; Placebos; Prednisone; Research Design | 1957 |
Controlling arthralgia with dexamesthasone and acetylsalicylic acid.
Topics: Arthralgia; Arthritis; Arthritis, Rheumatoid; Aspirin; Bursitis; Dexamethasone; Fibromyalgia; Humans | 1963 |
CLINICAL ASSESSMENT OF A NEW PYRAZOLONE DERIVATIVE (KB 95).
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoid; Aspirin; Chemi | 1963 |
DEGENERATIVE JOINT DISEASES--DISCS AND OSTEOARTHRITIS. II. DIAGNOSIS AND MANAGEMENT OF OSTEOARTHRITIS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Diagnosis, Differential; | 1963 |
[THE CUFF METHOD FOR THE ANTALGIC EVALUATION OF DIFFERENT DRUGS].
Topics: Aminopyrine; Arthritis; Arthritis, Rheumatoid; Aspirin; Caffeine; Gout; Osteoarthritis; Phenobarbita | 1963 |
RHEUMATISM RESEARCH: A SURVEY.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Aspirin; Epi | 1964 |
ANALGESIC EFFECT OF PRODILIDINE HYDROCHLORIDE (5054) IN ELDERLY PATIENTS WITH CHRONIC PAIN SYNDROME.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoid; Aspirin; Chron | 1964 |
CLINICAL ASPECTS AND MEDICAL MANAGEMENT OF CHRONIC ARTHRITIDES.
Topics: Adolescent; Adrenal Cortex Hormones; Antimalarials; Arthritis; Arthritis, Juvenile; Arthritis, Rheum | 1964 |
ARTHRITIS OF THE SPINE AND HIP.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Hip; Humans; Orthopedics; Osteoarthritis; Phenylbutazone; | 1964 |
SERUM SALICYLATE LEVELS IN OSTEOARTHRITIS FOLLOWING ORAL ADMINISTRATION OF A PREPARATION CONTAINING SALICYLSALICYLIC ACID.
Topics: Administration, Oral; Aspirin; Blood; Blood Chemical Analysis; Drug Therapy; Geriatrics; Humans; Ost | 1964 |
CLINICAL TEST OF INDOMETHACIN.
Topics: Analgesics; Analgesics, Non-Narcotic; Antimalarials; Antipyretics; Arthritis; Arthritis, Rheumatoid; | 1964 |
ANALGESIC COMBINATION IN HEADACHE.
Topics: Analgesics; Arthritis; Aspirin; Back Pain; Caffeine; Cervical Vertebrae; Drug Therapy; Headache; Hum | 1965 |
Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-R | 2003 |
Summaries for patients. Gastrointestinal side effects of rofecoxib and naproxen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors | 2003 |
Calcium succinate with aspirin in the treatment of rheumatic disease. I. A clinical evaluation.
Topics: Aspirin; Calcium; Humans; Osteoarthritis; Rheumatic Diseases; Succinates; Succinic Acid | 1951 |
Calcium succinate with aspirin as an anti-rheumatic agent.
Topics: Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Aspirin; Calcium; Humans; Osteoarthritis; Su | 1951 |
Serious gastrointestinal events from low dose analgesic use.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-Respons | 2004 |
CARISOPRODOL IN OSTEOARTHRITIS.
Topics: Aspirin; Carisoprodol; Geriatrics; Osteoarthritis; Statistics as Topic; Toxicology | 1964 |
Pattern of drug utilization among hypertensives in a Nigerian teaching hospital.
Topics: Aspirin; Cross-Sectional Studies; Diabetes Complications; Diuretics; Drug Combinations; Drug Interac | 2005 |
Effect of cardiovascular comorbidities and concomitant aspirin use on selection of cyclooxygenase inhibitor among rheumatologists.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cardiovascular Diseas | 2005 |
Endoscopic ulcers with low-dose aspirin and reality testing.
Topics: Aspirin; Dose-Response Relationship, Drug; Endoscopy, Digestive System; Humans; Osteoarthritis; Pept | 2005 |
Adverse effects of etoricoxib: other considerations.
Topics: Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug | 2005 |
Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; | 2006 |
Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2006 |
Bronchial asthma induced by indomethacin.
Topics: Aspirin; Asthma; Dextropropoxyphene; Drug Hypersensitivity; Humans; Indomethacin; Male; Middle Aged; | 1967 |
Medical management of patients with disability due to arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Bacterial Agents; Antimalarials; Arthritis, I | 1967 |
Osteoarthritis: pathophysiology, clinical features, management.
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Cartilage Diseases; Cartilage, Articular; Female; Humans; J | 1984 |
Effects of salicylates and other nonsteroidal anti-inflammatory drugs on articular cartilage.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Atrophy; Cartilage, Articular; Dogs; Extracellular Matri | 1984 |
Pain and inflammation.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Osteoarthritis; Pai | 1984 |
Osteoarthritis.
Topics: Adrenal Cortex Hormones; Adult; Aging; Anti-Inflammatory Agents; Arthrodesis; Arthroplasty; Aspirin; | 1984 |
Osteoarthritis in the hand.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Arthrodesis; Aspirin; Child, Preschoo | 1983 |
Enteric-coated aspirin.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Costs and Cost Analysis; Humans; Osteoarthritis; Tablets, Ente | 1983 |
[Treatment of painful muscular disorders of various degrees of severity. Comparison of 2 new suppository preparations].
Topics: Aspirin; Codeine; Diphenhydramine; Drug Combinations; Female; Gout; Humans; Male; Meprobamate; Middl | 1983 |
In vivo effect of aspirin on canine osteoarthritic cartilage.
Topics: Animals; Aspirin; Cartilage, Articular; Dogs; Glucuronates; Knee Joint; Osteoarthritis; Prostaglandi | 1983 |
An update on long-term efficacy and safety with benoxaprofen.
Topics: Alkaline Phosphatase; Anemia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Ibup | 1982 |
Aspirin and cataracts.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Cataract; Female; Humans; Male; Middle Aged; Osteoarthritis; R | 1982 |
Clinical features of first attack of rheumatic fever in adults.
Topics: Adult; Ankle Joint; Aspirin; Blood Sedimentation; Female; Hip Joint; Humans; Iraq; Knee Joint; Leuko | 1982 |
Salicylate-arthropathy. Accelerated coxarthrosis during long-term treatment with acetylsalicylic acid.
Topics: Aged; Aspirin; Female; Hip; Humans; Indomethacin; Osteoarthritis | 1981 |
Anti-inflammatory agents in arthritis.
Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Aspirin; Bursitis; Humans; Osteoarthriti | 1981 |
Senile cataracts: evidence for acceleration by diabetes and deceleration by salicylate.
Topics: Age Factors; Aged; Aspirin; Cataract; Diabetes Complications; Humans; Middle Aged; Osteoarthritis; T | 1981 |
Marked suppression by salicylate of the augmented proteoglycan synthesis in osteoarthritic cartilage.
Topics: Animals; Aspirin; Body Water; Cartilage, Articular; Cells, Cultured; Dogs; Glycosaminoglycans; Knee; | 1980 |
Gastroscopic evaluation of anti-inflammatory agents.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Administration Schedule; | 1980 |
An experimental model of osteoarthritis in rabbit.
Topics: Animals; Aspirin; Disease Models, Animal; Indomethacin; Male; Osteoarthritis; Rabbits | 1994 |
Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cartilage, Articular; Chondroitin; Hu | 1994 |
Nonsteroidal antiinflammatory drug desensitization using flurbiprofen (Ansaid)
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cross Reactions; Des | 1993 |
Connective tissue activation. XXXVII. Effects of cytokine combinations, implications for an integrated cytokine network.
Topics: Arthritis, Rheumatoid; Aspirin; Cells, Cultured; Connective Tissue; Culture Media, Conditioned; Cyto | 1997 |
North of England evidence based guidelines development project: methods of developing guidelines for efficient drug use in primary care.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Ag | 1998 |
Contraindicated NSAIDs are frequently prescribed to elderly patients with peptic ulcer disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Co | 2002 |
Trends in medication use for osteoarthritis treatment.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Drug Utilization; | 2002 |
Prostaglandins in the rheumatic diseases.
Topics: Arthritis, Rheumatoid; Aspirin; Bone Resorption; Cell Line; Colchicine; Cyclic AMP; Flufenamic Acid; | 1975 |
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin).
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; H | 1977 |
[Gastrointestinal hemorrhage during treatment with ibuprofen (Brufen)].
Topics: Aged; Aspirin; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Midd | 1977 |
Rheumatology.
Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Aspirin; Child; Collagen Diseases; Female; HLA Antig | 1978 |
Management of osteoarthritis.
Topics: Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Osteoarthritis; Pentazocine; Physical Thera | 1979 |
Effect of C 21 524-Su (pirprofen) on spontaneous osteoarthrosis in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Knee Joint; Male; Mice; Mice, Inbred C57BL; Osteoarthrit | 1978 |
Nephrotoxicity studies on aspirin and diflunisal.
Topics: Acetylglucosamine; Analgesics; Aspirin; Biphenyl Compounds; Epithelial Cells; Female; Humans; Kidney | 1978 |
Dissociation of acetylsalicylic acid in blood and joint fluid.
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Buffers; Crohn Disease; Delayed-Action Preparations; Focal In | 1977 |
Selecting and preparing patients for total hip replacement.
Topics: Aged; Anticoagulants; Arthritis, Rheumatoid; Arthroplasty; Aspirin; Blood Coagulation; Blood Platele | 1977 |
Chloroquine toxicity due to long-term Elestol for osteoarthrosis.
Topics: Aged; Aspirin; Chloroquine; Drug Combinations; Humans; Male; Osteoarthritis; Pigmentation Disorders; | 1977 |
[Transport of salicylates from blood to joint fluid (author's transl)].
Topics: Arthritis, Rheumatoid; Aspirin; Biological Transport; Humans; Osteoarthritis; Synovial Fluid; Synovi | 1977 |
Mortality among arthritics.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Cardiovascular Diseases; Central Nervous System Diseases; Coro | 1976 |
Activity of anti-inflammatory drugs on an experimental model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cartilage, Articular; Catalase; Disease Models, Animal; | 1976 |
Rheumatic diseases. 2. Therapeutic considerations.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Aspirin; Calcinosis; Carpal Tunnel Syndrome; Colchic | 1976 |
Bone and joint diseases in the elderly.
Topics: Activities of Daily Living; Adrenal Cortex Hormones; Age Factors; Aged; Anti-Inflammatory Agents; Ar | 1976 |
The aging skeleton. Osteoporosis and degenerative arthritis.
Topics: Age Factors; Aged; Aspirin; Estrogens; Female; Fracture Fixation; Humans; Ibuprofen; Indomethacin; J | 1975 |
Evaluation of ibuprofen (Motrin). A new antirheumatic agent.
Topics: Administration, Oral; Arthritis, Rheumatoid; Aspirin; Central Nervous System; Digestive System; Drug | 1975 |
Sensible prescribing. VII. The treatment of osteoarthrosis.
Topics: Aged; Aspirin; Decision Making; Exercise Therapy; Humans; Middle Aged; Osteoarthritis | 1975 |
[Methoxypropriocin in the treatment of degenerative bone disease (comparative studies)].
Topics: Aspirin; Benzydamine; Chronic Disease; Humans; Indomethacin; Naphthaleneacetic Acids; Naproxen; Oste | 1976 |
Letter: Ibuprofen and visual function.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Eye; Female; Humans; Ibuprofen; Osteoarthritis; Phenylpropiona | 1976 |
The absorption of Safapryn in patients with arthritis.
Topics: Acetaminophen; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Drug Combinations; Female; Humans; Intes | 1976 |
Effect of aspirin on heterotopic ossification after total hip arthroplasty in men who have osteoarthrosis.
Topics: Aged; Aged, 80 and over; Aspirin; Hip Prosthesis; Humans; Length of Stay; Male; Middle Aged; Ossific | 1991 |
Rheumatoid disease and related arthropathies. I. Systemic findings, medical therapy, and peripheral joint surgery.
Topics: Adolescent; Antimalarials; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Finger Joint; Hip Jo | 1986 |
Nonsteroidal antiinflammatory drugs and articular cartilage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cartilage, Articular; Dogs; In Vitro Tech | 1987 |
Rheumatoid arthritis: diagnosis and management.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Arthritis, Infectious; Arthritis, Juvenile; Arthritis, | 1986 |
The influence of total hip replacement on hip pain and the use of analgesics.
Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1985 |
Osteoarthritis: increasing mobility and reducing disability.
Topics: Acetaminophen; Adrenal Cortex Hormones; Aged; Ankle Joint; Anti-Inflammatory Agents; Aspirin; Cervic | 1986 |
Safety of flurbiprofen in the treatment of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis. A summary of liver and kidney assay data.
Topics: Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspi | 1986 |
Aspirin dosing using 15 grain enteric coated tablets.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Gastrointestinal Diseases; Humans; Male; Middle | 1985 |
Worldwide experience with diclofenac in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Humans; Indomethacin; Naproxen; Ost | 1985 |
Diclofenac sodium in the treatment of rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Female; Humans; Ibuprofen; Male; Mi | 1985 |
A classification of headache.
Topics: Antidepressive Agents; Anxiety; Arteritis; Aspirin; Depression; Ergot Alkaloids; Facial Neuralgia; H | 1970 |
Pain patterns in the rheumatic disorders.
Topics: Anxiety; Arthritis; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Depression; Giant Cell Arteriti | 1972 |
Effect of a synthetic hexosamine derivative on mucopolysaccharide synthesis by human capsule and synovium.
Topics: Aspirin; Carbon Radioisotopes; Chondroitin; Connective Tissue; Glucosamine; Glucose; Glycosaminoglyc | 1973 |
Effect of gold salts and other drugs on the release and activity of lysosomal hydrolases.
Topics: Acid Phosphatase; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Aspirin; Cath | 1968 |
Complications revisited. The debit side of total hip replacement.
Topics: Anti-Bacterial Agents; Arthritis, Rheumatoid; Arthroplasty; Aspirin; Bone Cements; Dextrans; Female; | 1973 |
Anti-inflammatory drugs in rheumatic diseases.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin | 1974 |
Pain in osteoarthrosis.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Cartilage Diseases; Exercise Therapy; Hip; Humans; Im | 1974 |
Analgesics and non-steroid anti-inflammatory agents in rheumatic disease.
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Bone Neoplasms; Gout; Humans; | 1972 |
Which drugs for which rheumatic disorder?
Topics: Analgesics; Arthritis, Rheumatoid; Aspirin; Gold; Gout; Humans; Indomethacin; Lupus Erythematosus, S | 1972 |
Naproxen. Proceedings from an International Medical Symposium presented by Syntex Corporation 7-8 May 1973, Geneva, Switzerland.
Topics: Adolescent; Adult; Aged; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspir | 1973 |
Gastro-intestinal blood loss with sustained release aspirin.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Chromium Radioisotopes; Delayed-Action Prep | 1973 |
Degenerative joint disease (oasteoarthritis).
Topics: Aged; Aging; Aspirin; Cartilage, Articular; Chondroitin; Female; Finger Joint; Glucocorticoids; Hip | 1973 |
Transport of salicylates from blood to joint fluid.
Topics: Administration, Oral; Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Bursitis; Humans; Middle Age | 1973 |
Aspirin and the kidney. New Zealand Rheumatism Association Study.
Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hum | 1974 |
Clinical studies on inflammation in small diarthrodial joints. Technetium ( 99m Tc) percentage uptakes in various arthritides and studies on the effect of aspirin in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Aspirin; Female; Finger Joint; | 1972 |
[Therapeutic trends in osteoarthrosis].
Topics: Adrenal Cortex Hormones; Analgesics; Anti-Inflammatory Agents; Aspirin; Calcium; Humans; Indomethaci | 1972 |
Approaches to the patient with degenerative joint disease.
Topics: Adrenal Cortex Hormones; Aspirin; Exercise Therapy; Hip Joint; Hot Temperature; Humans; Indomethacin | 1971 |
Comparison of flufenamic acid with aspirin and paracetamol in terms of gastrointestinal blood loss.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chromium Isotopes; Fe | 1966 |
[Research and observations on the use of acetylsalicylic acid with delayed absorption in the therapy of rheumatic diseases].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Delayed-Action Preparations; Female; Humans | 1970 |
Some aspects in the quantitation of inflammation in joints of patients suffering from rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Reactive; Arthritis, Rheumatoid; Aspir | 1970 |
[Paloxin. An antirheumatic drug with few complications of ventricular irritations].
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Female; Humans; Male; Middle Aged; Osteoarthritis; Oxid | 1967 |