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aspirin and Neutropenia

aspirin has been researched along with Neutropenia in 21 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"Ticlopidine is an antiplatelet agent that has been proven efficacious in preventing vascular events in patients with a history of vasculopathy."5.30Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. ( Armstrong, PW; Brown, NE; Gill, S; Majumdar, S, 1997)
" Furthermore, the simpler dosing regimen, the absence of neutropenia, and the lower frequency of other side effects make it a safe alternative to ticlopidine."5.09Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. ( Collins, M; Colombo, A; Iyer, S; Kreps, E; Maida, R; Moses, JW; Moussa, I; Oetgen, M; Roubin, G; Wang, X, 1999)
"Compared with aspirin, clopidogrel reduced the combined risk of ischaemic stroke, myocardial infarction or vascular death by 8."5.09Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events. ( Boissel, JP; Gent, M; Harker, LA; Pilgrim, AJ, 1999)
"The significance of neutropenia in Kawasaki disease (KD) has not been fully elucidated as yet."2.74Neutropenia in the acute phase of Kawasaki disease and prevention of coronary artery aneurysm. ( Hamaoka, K; Ito, H; Kiyosawa, N; Onouchi, Z; Ozawa, S; Sakata, K, 2009)
"048), and the frequency of adverse events was not significantly different between the two treatment groups."2.67The efficacy and safety of ticlopidine and aspirin in non-whites: analysis of a patient subgroup from the Ticlopidine Aspirin Stroke Study. ( Weisberg, LA, 1993)
"Ticlopidine has not been formally compared with aspirin in patients with a completed stroke."2.67Ticlopidine versus aspirin for the prevention of recurrent stroke. Analysis of patients with minor stroke from the Ticlopidine Aspirin Stroke Study. ( Harbison, JW, 1992)
"Ticlopidine is an antiplatelet agent that has been proven efficacious in preventing vascular events in patients with a history of vasculopathy."1.30Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative. ( Armstrong, PW; Brown, NE; Gill, S; Majumdar, S, 1997)
"Aspirin treatment in combination with neutropenia produced a 50% reduction in whole blood platelet aggregation, resulted in a significant inhibition of platelet deposition to deeply injured arteries, and decreased vasoconstriction by 66% to 15."1.29Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs. ( Lacoste, LL; Lam, JY; Merhi, Y, 1994)
"Pretreatment with aspirin (10 mg/kg) protected the sheep against the pulmonary vascular response to 20 micrograms of PAF and blocked completely the thromboxane synthesis."1.27Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep. ( McDonald, JW; Smallbone, BW; Taylor, NE, 1987)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19906 (28.57)18.7374
1990's12 (57.14)18.2507
2000's3 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Onouchi, Z1
Hamaoka, K1
Ozawa, S1
Sakata, K1
Kiyosawa, N1
Ito, H1
Wallace, JL1
Zamuner, SR1
McKnight, W1
Dicay, M1
Mencarelli, A1
del Soldato, P1
Fiorucci, S1
Goyan, JE1
Merhi, Y1
Lacoste, LL1
Lam, JY1
Oster, G1
Huse, DM1
Lacey, MJ1
Epstein, AM1
Weisberg, LA1
Stroncek, DF1
Clay, ME1
Smith, J1
Ilstrup, S1
Oldham, F1
McCullough, J1
Haushofer, A1
Halbmayer, WM1
Prachar, H1
Neumann, FJ1
Hall, D1
Schömig, A1
Gill, S1
Majumdar, S1
Brown, NE1
Armstrong, PW1
Moussa, I1
Oetgen, M1
Roubin, G1
Colombo, A1
Wang, X1
Iyer, S1
Maida, R1
Collins, M1
Kreps, E1
Moses, JW1
Harker, LA1
Boissel, JP1
Pilgrim, AJ1
Gent, M1
Diener, HC1
Ekert, H1
Waters, KD1
Dawson, AA1
Harbison, JW1
Lee, M1
Aldred, K1
Lee, E1
Feldman, M1
FitzGerald, GA1
Cunningham, FG1
Gant, NF1
Smallbone, BW1
Taylor, NE1
McDonald, JW1
Merz, B1

Reviews

1 review available for aspirin and Neutropenia

ArticleYear
Stroke prevention: antiplatelet and antithrombolytic therapy.
    Haemostasis, 2000, Volume: 30 Suppl 3

    Topics: Anticoagulants; Aspirin; Brain Damage, Chronic; Carotid Stenosis; Clinical Trials as Topic; Clopidog

2000

Trials

6 trials available for aspirin and Neutropenia

ArticleYear
Neutropenia in the acute phase of Kawasaki disease and prevention of coronary artery aneurysm.
    Pediatrics international : official journal of the Japan Pediatric Society, 2009, Volume: 51, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Coronary Aneurysm; Humans; Immunoglobulins, Intrav

2009
The efficacy and safety of ticlopidine and aspirin in non-whites: analysis of a patient subgroup from the Ticlopidine Aspirin Stroke Study.
    Neurology, 1993, Volume: 43, Issue:1

    Topics: Aged; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Double-Blind Method; Female; Follow-Up Stu

1993
Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Thrombosis; Diarrhea; D

1999
Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events.
    Drug safety, 1999, Volume: 21, Issue:4

    Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Gastrointest

1999
Ticlopidine versus aspirin for the prevention of recurrent stroke. Analysis of patients with minor stroke from the Ticlopidine Aspirin Stroke Study.
    Stroke, 1992, Volume: 23, Issue:12

    Topics: Adult; Aspirin; Cerebrovascular Disorders; Diarrhea; Double-Blind Method; Female; Humans; Male; Midd

1992
Ticlopidine in unstable angina. A more expensive aspirin?
    Circulation, 1990, Volume: 82, Issue:1

    Topics: Angina Pectoris; Angina, Unstable; Aspirin; Clinical Trials as Topic; Cost-Benefit Analysis; Cycloox

1990

Other Studies

14 other studies available for aspirin and Neutropenia

ArticleYear
Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi

2004
Ticlopidine: quo vadis? Adverse reactions in man.
    Agents and actions. Supplements, 1984, Volume: 15

    Topics: Anticoagulants; Aspirin; Diarrhea; Humans; Neutropenia; Product Surveillance, Postmarketing; Thiophe

1984
Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs.
    Circulation, 1994, Volume: 90, Issue:2

    Topics: Angioplasty, Balloon; Animals; Aspirin; Carotid Arteries; Carotid Artery Injuries; Neutropenia; Neut

1994
Cost-effectiveness of ticlopidine in preventing stroke in high-risk patients.
    Stroke, 1994, Volume: 25, Issue:6

    Topics: Aged; Aspirin; Cerebrovascular Disorders; Cohort Studies; Cost-Benefit Analysis; Decision Support Te

1994
Changes in blood counts after the administration of granulocyte-colony-stimulating factor and the collection of peripheral blood stem cells from healthy donors.
    Transfusion, 1996, Volume: 36, Issue:7

    Topics: Adult; Aspirin; Contraindications; Filgrastim; Follow-Up Studies; Granulocyte Colony-Stimulating Fac

1996
Neutropenia with ticlopidine plus aspirin.
    Lancet (London, England), 1997, Feb-15, Volume: 349, Issue:9050

    Topics: Agranulocytosis; Aspirin; Coronary Disease; Humans; Monitoring, Physiologic; Neutropenia; Platelet A

1997
Neutropenia with ticlopidine plus aspirin.
    Lancet (London, England), 1997, May-24, Volume: 349, Issue:9064

    Topics: Aspirin; Chemoprevention; Coronary Thrombosis; Coronary Vessels; Drug Combinations; Fibrinolytic Age

1997
Ticlopidine-associated pancytopenia: implications of an acetylsalicylic acid alternative.
    The Canadian journal of cardiology, 1997, Volume: 13, Issue:10

    Topics: Aspirin; Cardiovascular Diseases; Drug Resistance; Fatal Outcome; Female; Humans; Middle Aged; Neutr

1997
Hematologic emergencies in children.
    Paediatrician, 1978, Volume: 7, Issue:4-5

    Topics: Acute Disease; Acute Kidney Injury; Adolescent; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Asp

1978
Drug-induced haematological disease.
    British medical journal, 1979, May-05, Volume: 1, Issue:6172

    Topics: Anemia; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Aspirin; Bone Marrow Diseases; Hemato

1979
Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats.
    The American journal of physiology, 1992, Volume: 263, Issue:6 Pt 1

    Topics: Acute Disease; Animals; Aspirin; Blood Cell Count; Eicosanoids; Gastric Mucosa; Immune Sera; Leucovo

1992
Prevention of preeclampsia--a reality?
    The New England journal of medicine, 1989, Aug-31, Volume: 321, Issue:9

    Topics: Aspirin; Female; Humans; Infant, Newborn; Neutropenia; Pre-Eclampsia; Pregnancy

1989
Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: Animals; Aspirin; Complement Activation; Complement System Proteins; Dose-Response Relationship, Dru

1987
Large trial finds ticlopidine superior to aspirin in preventing stroke.
    JAMA, 1989, Mar-17, Volume: 261, Issue:11

    Topics: Aspirin; Cerebrovascular Disorders; Female; Follow-Up Studies; Humans; Male; Neutropenia; Random All

1989