aspirin has been researched along with Nasal Obstruction in 13 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Nasal Obstruction: Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of nasal congestion associated with the common cold." | 9.11 | Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold. ( Loose, I; Winkel, M, 2004) |
| "To investigate the impact of nasal polyps on quality of life compared with the Spanish general population using the SF-36 questionnaire; and to evaluate the impact of asthma and aspirin sensitivity on quality of life in patients with nasal polyposis." | 7.73 | The impact of asthma and aspirin sensitivity on quality of life of patients with nasal polyposis. ( Alobid, I; Benítez, P; Bernal-Sprekelsen, M; Guilemany, JM; Mullol, J; Picado, C, 2005) |
| "The aspirin triad (nasal polyposis, asthma and sensitivity to aspirin) is a well-recognized clinical entity, also known as aspirin-induced asthma (AIA)." | 7.70 | Effects of sinus surgery on asthma in aspirin triad patients. ( Higuchi, Y; Kawasaki, M; Nakamura, H; Takahashi, S, 1999) |
| "It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of nasal congestion associated with the common cold." | 5.11 | Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold. ( Loose, I; Winkel, M, 2004) |
| "To investigate the impact of nasal polyps on quality of life compared with the Spanish general population using the SF-36 questionnaire; and to evaluate the impact of asthma and aspirin sensitivity on quality of life in patients with nasal polyposis." | 3.73 | The impact of asthma and aspirin sensitivity on quality of life of patients with nasal polyposis. ( Alobid, I; Benítez, P; Bernal-Sprekelsen, M; Guilemany, JM; Mullol, J; Picado, C, 2005) |
| "The aspirin triad (nasal polyposis, asthma and sensitivity to aspirin) is a well-recognized clinical entity, also known as aspirin-induced asthma (AIA)." | 3.70 | Effects of sinus surgery on asthma in aspirin triad patients. ( Higuchi, Y; Kawasaki, M; Nakamura, H; Takahashi, S, 1999) |
| "Between 8-20 percent of adult asthmatics experience bronchospasm following ingestion of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs)." | 3.70 | NSAID-induced bronchospasm--a common and serious problem. A report from MEDSAFE, the New Zealand Medicines and Medical Devices Safety Authority. ( Sturtevant, J, 1999) |
| "However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals." | 1.34 | Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis. ( Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rozsasi, A | 1 |
| Keck, T | 1 |
| Merkonidis, C | 1 |
| Gudziol, V | 1 |
| Cecchini, MP | 1 |
| Gerber, J | 1 |
| Seo, HS | 1 |
| Bachert, C | 1 |
| Hummel, T | 1 |
| Muñoz-Cano, R | 1 |
| Bartra, J | 1 |
| Sanchez-Lopez, J | 1 |
| Picado, C | 2 |
| Bissinger, I | 1 |
| Valero, A | 1 |
| Macchia, L | 1 |
| Caiaffa, MF | 1 |
| Vacca, A | 1 |
| Tursi, A | 1 |
| Johansson, L | 1 |
| Brämerson, A | 1 |
| Holmberg, K | 1 |
| Melén, I | 1 |
| Akerlund, A | 1 |
| Bende, M | 1 |
| Crovetto, M | 1 |
| Solano, D | 1 |
| Centeno, J | 1 |
| Loose, I | 1 |
| Winkel, M | 1 |
| Alobid, I | 1 |
| Benítez, P | 1 |
| Bernal-Sprekelsen, M | 1 |
| Guilemany, JM | 1 |
| Mullol, J | 1 |
| Bonfils, P | 1 |
| Avan, P | 1 |
| Malinvaud, D | 1 |
| Hopkins, C | 1 |
| Browne, JP | 1 |
| Slack, R | 1 |
| Lund, V | 1 |
| Brown, P | 1 |
| Han, HY | 1 |
| Nabe, T | 1 |
| Mizutani, N | 1 |
| Fujii, M | 1 |
| Terada, T | 1 |
| Takenaka, H | 1 |
| Kohno, S | 1 |
| Nakamura, H | 1 |
| Kawasaki, M | 1 |
| Higuchi, Y | 1 |
| Takahashi, S | 1 |
| Sturtevant, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Thymoquinone and Olive Oil on Wound Healing After Endoscopic Sinus Surgery in Patients With Nasal Polyposis[NCT06070311] | 50 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | |||
| Role of Short Term Systemic Corticosteroid Therapy in the Management of Chronic Rhinosinusitis Without Nasal Polyps[NCT01676415] | Phase 4 | 9 participants (Actual) | Interventional | 2012-08-31 | Terminated (stopped due to participants are no longer receiving intervention due to clinical logistics) | ||
| Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis[NCT03472144] | Phase 3 | 60 participants (Anticipated) | Interventional | 2017-07-07 | Recruiting | ||
| High Volume Saline Irrigation in the Post-operative Management of Chronic Rhinosinusitis: A Multicenter Randomized Single-Blind Controlled Trial[NCT02636959] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | ||
| Role of Epithelial Barrier Integrity in Biologic Treatment Response of Severe Asthmatics With/Out Chronic Rhinosinusitis With Nasal Polyps (CRSwNP). Can Shedding of Epithelial Barrier Proteins be Used as Biomarker in Severe Asthma With/Out CRSwNP Manageme[NCT05365841] | 85 participants (Anticipated) | Observational | 2022-05-15 | Not yet recruiting | |||
| Ideal Frequency of Postoperative High Volume Saline Irrigations Following Endoscopic Sinus Surgery[NCT01680705] | 75 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The medication side-effect and compliance inventory is a questionnaire to evaluate the frequency and severity of common side effects associated with the medications used in this study. (NCT01676415)
Timeframe: 4-6 weeks and 3 months after initiation of treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Prednisone | 0 |
| Topical Mometasone | 0 |
Change from baseline in individual symptom severity. The taskforce symptom inventory is a visual analog scale of the severity of the 4 major symptoms making up the clinical diagnostic criteria of CRS. (NCT01676415)
Timeframe: 4-6 weeks and 3 months after initiation of treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Prednisone | 0 |
| Topical Mometasone | 0 |
"The Sino-nasal Outcome Test-22 is a validated questionnaire that measures 22 nasal and quality of life symptoms (nasal obstruction and loss of smell and taste) ranked from 0 (not a problem) to 5 (problem as bad as it can be).~Min score= 0, Max score= 110 (worst possible problem on all symptoms)~Change from baseline of the SNOT-22 score. The SNOT-22 questionnaire is a 22-item disease-specific health related quality of life instrument validated for use in chronic rhinosinusitis." (NCT01676415)
Timeframe: 4-6 weeks and 3 months after initiation of treatment
| Intervention | units on a scale (Mean) | |
|---|---|---|
| 4-6 WEEKS | 3 MONTHS | |
| Prednisone | 45.75 | 49 |
| Topical Mometasone | 34.4 | 34.4 |
1 trial available for aspirin and Nasal Obstruction
| Article | Year |
|---|---|
Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Area Under | 2004 |
12 other studies available for aspirin and Nasal Obstruction
| Article | Year |
|---|---|
[Self-desensitization with aspirin in a patient with aspirin intolerance].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Pro | 2009 |
Improvement of chronic rhinitis under aspirin.
Topics: Aspirin; Chronic Disease; Cyclooxygenase Inhibitors; Humans; Magnetic Resonance Imaging; Male; Middl | 2012 |
Acoustic rhinometry and aspirin nasal challenge in the diagnosis of aspirin-intolerant asthma: clinical finding and safety aspects.
Topics: Administration, Intranasal; Adult; Aspirin; Asthma, Aspirin-Induced; Feasibility Studies; Female; Fo | 2013 |
General adverse reaction to aspirin administered by transdermal iontophoresis.
Topics: Administration, Cutaneous; Adolescent; Analgesics; Angioedema; Aspirin; Cough; Dyspnea; Erythema; Hu | 2002 |
Clinical relevance of nasal polyps in individuals recruited from a general population-based study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Asthma; Cross-Sectional Studies; Drug Hypersensitivity; Fem | 2004 |
[Recurrent polychondritis: apropos of a case].
Topics: Aspirin; Autoimmune Diseases; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Conjunctivitis; Cyclos | 2003 |
The impact of asthma and aspirin sensitivity on quality of life of patients with nasal polyposis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Female; Humans; Male; Middle | 2005 |
Influence of allergy on the symptoms and treatment of nasal polyposis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Beclomethasone; Bronchial Provocation Test | 2006 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma | 2007 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofen | 2007 |
Effects of sinus surgery on asthma in aspirin triad patients.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Airway Resistance; Aspirin; Asthma; Chro | 1999 |
NSAID-induced bronchospasm--a common and serious problem. A report from MEDSAFE, the New Zealand Medicines and Medical Devices Safety Authority.
Topics: Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Spasm; Chroni | 1999 |