aspirin has been researched along with Mesothelioma in 3 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiproliferative activity of the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl[μ-(2-ethylphenyl)methanol]dicobalt (Co-EPM) was investigated on malignant pleural mesothelioma (MPM) cell lines, having an epithelioid or a sarcomatoid phenotype." | 7.79 | The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells. ( Bonarrigo, I; Gabano, E; Gust, R; Osella, D; Ravera, M; Zanellato, I, 2013) |
| "A murine model of asbestos-induced mesothelioma was used to test this hypothesis by providing the NSAID, aspirin, daily in the feed at 50mg/kg or 250 mg/kg." | 3.80 | Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort. ( Alfonso, H; Bill Musk, AW; Lake, RA; Nowak, AK; Olsen, N; Robinson, BW; Robinson, C; Woo, S, 2014) |
| "The antiproliferative activity of the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl[μ-(2-ethylphenyl)methanol]dicobalt (Co-EPM) was investigated on malignant pleural mesothelioma (MPM) cell lines, having an epithelioid or a sarcomatoid phenotype." | 3.79 | The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells. ( Bonarrigo, I; Gabano, E; Gust, R; Osella, D; Ravera, M; Zanellato, I, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zanellato, I | 1 |
| Bonarrigo, I | 1 |
| Ravera, M | 1 |
| Gabano, E | 1 |
| Gust, R | 1 |
| Osella, D | 1 |
| Robinson, C | 1 |
| Alfonso, H | 1 |
| Woo, S | 1 |
| Olsen, N | 1 |
| Bill Musk, AW | 1 |
| Robinson, BW | 1 |
| Nowak, AK | 1 |
| Lake, RA | 1 |
| Yang, H | 1 |
| Pellegrini, L | 1 |
| Napolitano, A | 1 |
| Giorgi, C | 1 |
| Jube, S | 1 |
| Preti, A | 1 |
| Jennings, CJ | 1 |
| De Marchis, F | 1 |
| Flores, EG | 1 |
| Larson, D | 1 |
| Pagano, I | 1 |
| Tanji, M | 1 |
| Powers, A | 1 |
| Kanodia, S | 1 |
| Gaudino, G | 1 |
| Pastorino, S | 1 |
| Pass, HI | 1 |
| Pinton, P | 1 |
| Bianchi, ME | 1 |
| Carbone, M | 1 |
3 other studies available for aspirin and Mesothelioma
| Article | Year |
|---|---|
The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Carbon Monoxide; | 2013 |
Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asbestos; Aspirin; Chemoprevention; Cohort S | 2014 |
Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.
Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cell Li | 2015 |