Page last updated: 2024-10-23

aspirin and Mesothelioma

aspirin has been researched along with Mesothelioma in 3 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"The antiproliferative activity of the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl[μ-(2-ethylphenyl)methanol]dicobalt (Co-EPM) was investigated on malignant pleural mesothelioma (MPM) cell lines, having an epithelioid or a sarcomatoid phenotype."7.79The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells. ( Bonarrigo, I; Gabano, E; Gust, R; Osella, D; Ravera, M; Zanellato, I, 2013)
"A murine model of asbestos-induced mesothelioma was used to test this hypothesis by providing the NSAID, aspirin, daily in the feed at 50mg/kg or 250 mg/kg."3.80Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort. ( Alfonso, H; Bill Musk, AW; Lake, RA; Nowak, AK; Olsen, N; Robinson, BW; Robinson, C; Woo, S, 2014)
"The antiproliferative activity of the aspirin derivative [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt (Co-ASS) and its analogue hexacarbonyl[μ-(2-ethylphenyl)methanol]dicobalt (Co-EPM) was investigated on malignant pleural mesothelioma (MPM) cell lines, having an epithelioid or a sarcomatoid phenotype."3.79The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells. ( Bonarrigo, I; Gabano, E; Gust, R; Osella, D; Ravera, M; Zanellato, I, 2013)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zanellato, I1
Bonarrigo, I1
Ravera, M1
Gabano, E1
Gust, R1
Osella, D1
Robinson, C1
Alfonso, H1
Woo, S1
Olsen, N1
Bill Musk, AW1
Robinson, BW1
Nowak, AK1
Lake, RA1
Yang, H1
Pellegrini, L1
Napolitano, A1
Giorgi, C1
Jube, S1
Preti, A1
Jennings, CJ1
De Marchis, F1
Flores, EG1
Larson, D1
Pagano, I1
Tanji, M1
Powers, A1
Kanodia, S1
Gaudino, G1
Pastorino, S1
Pass, HI1
Pinton, P1
Bianchi, ME1
Carbone, M1

Other Studies

3 other studies available for aspirin and Mesothelioma

ArticleYear
The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells.
    Metallomics : integrated biometal science, 2013, Volume: 5, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Carbon Monoxide;

2013
Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort.
    Lung cancer (Amsterdam, Netherlands), 2014, Volume: 86, Issue:1

    Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asbestos; Aspirin; Chemoprevention; Cohort S

2014
Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.
    Cell death & disease, 2015, Jun-11, Volume: 6

    Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cell Li

2015