aspirin has been researched along with Meningitis, Tuberculous in 10 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a phase 2, open-label, parallel-design, randomized, controlled trial to assess the safety of high-dose rifampicin, linezolid, and high-dose aspirin in HIV-associated TBM." | 5.69 | A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial. ( Aziz, S; Banderker, IA; Black, J; Bremer, M; Candy, S; Crede, T; Daroowala, R; Davis, AG; Denti, P; Goliath, R; Jackson, A; Jason Liang, C; Kadernani, Y; Koekemoer, S; Lai Sai, L; Lai, RPJ; Maartens, G; Maxebengula, M; Meintjes, G; Moosa, MS; Naude, J; Offiah, C; Raubenheimer, P; Sihoyiya, T; Stegmann, S; Stek, C; Szymanski, P; Vallie, Y; Vorster, I; Wahl, G; Wasserman, S; Wilkinson, RJ, 2023) |
| "To evaluate the efficacy and safety of aspirin in preventing stroke and mortality in tuberculous meningitis (TBM)." | 5.14 | Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial. ( Kalita, J; Misra, UK; Nair, PP, 2010) |
| "Using a combination of aspirin, anti-tuberculosis drugs and steroids may help to reduce the number of strokes and deaths in patients with tuberculous meningitis." | 3.88 | Can aspirin help? ( Kalantri, A; Kalantri, S, 2018) |
| "Levofloxacin was discontinued more frequently than rifampicin due to SAEs (16 versus 4, P = 0." | 2.79 | Safety and efficacy of levofloxacin versus rifampicin in tuberculous meningitis: an open-label randomized controlled trial. ( Bhoi, SK; Kalita, J; Misra, UK; Prasad, S, 2014) |
| "Aspirin has an antithrombotic action at low dose and anti-ischemic and anti-inflammatory properties, which are dose-related." | 2.76 | The role of aspirin in childhood tuberculous meningitis. ( Janse van Rensburg, A; Laubscher, JA; Schoeman, JF; Springer, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maitre, T | 1 |
| Bonnet, M | 1 |
| Calmy, A | 1 |
| Raberahona, M | 1 |
| Rakotoarivelo, RA | 1 |
| Rakotosamimanana, N | 1 |
| Ambrosioni, J | 1 |
| Miró, JM | 1 |
| Debeaudrap, P | 1 |
| Muzoora, C | 1 |
| Davis, A | 1 |
| Meintjes, G | 3 |
| Wasserman, S | 3 |
| Wilkinson, R | 1 |
| Eholié, S | 1 |
| Nogbou, FE | 1 |
| Calvo-Cortes, MC | 1 |
| Chazallon, C | 1 |
| Machault, V | 1 |
| Anglaret, X | 1 |
| Bonnet, F | 1 |
| Davis, AG | 2 |
| Stek, C | 2 |
| Maxebengula, M | 2 |
| Jason Liang, C | 2 |
| Stegmann, S | 2 |
| Koekemoer, S | 2 |
| Jackson, A | 2 |
| Kadernani, Y | 2 |
| Bremer, M | 2 |
| Daroowala, R | 2 |
| Aziz, S | 2 |
| Goliath, R | 2 |
| Lai Sai, L | 2 |
| Sihoyiya, T | 2 |
| Denti, P | 2 |
| Lai, RPJ | 2 |
| Crede, T | 2 |
| Naude, J | 2 |
| Szymanski, P | 2 |
| Vallie, Y | 2 |
| Banderker, IA | 2 |
| Moosa, MS | 2 |
| Raubenheimer, P | 2 |
| Candy, S | 2 |
| Offiah, C | 2 |
| Wahl, G | 2 |
| Vorster, I | 2 |
| Maartens, G | 2 |
| Black, J | 2 |
| Wilkinson, RJ | 2 |
| Colas, RA | 1 |
| Nhat, LTH | 1 |
| Thuong, NTT | 1 |
| Gómez, EA | 1 |
| Ly, L | 1 |
| Thanh, HH | 1 |
| Mai, NTH | 1 |
| Phu, NH | 1 |
| Thwaites, GE | 1 |
| Dalli, J | 1 |
| Bhasin, H | 1 |
| Goyal, M | 1 |
| Sharma, S | 1 |
| Kalantri, A | 1 |
| Kalantri, S | 1 |
| Kalita, J | 2 |
| Misra, UK | 2 |
| Prasad, S | 1 |
| Bhoi, SK | 1 |
| Nair, PP | 1 |
| Schoeman, JF | 1 |
| Janse van Rensburg, A | 1 |
| Laubscher, JA | 1 |
| Springer, P | 2 |
| Schoeman, J | 1 |
| Mansvelt, E | 1 |
| van Rensburg, AJ | 1 |
| Carlini, S | 1 |
| Fourie, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intensified Tuberculosis Treatment to Reduce the Mortality of HIV-infected and Uninfected Patients With Tuberculosis Meningitis: a Phase III Randomized Controlled Trial (Acronym: INTENSE-TBM)[NCT04145258] | Phase 3 | 768 participants (Anticipated) | Interventional | 2021-02-07 | Recruiting | ||
| A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis[NCT03092817] | Phase 3 | 520 participants (Actual) | Interventional | 2017-05-25 | Active, not recruiting | ||
| A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for the Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified by Leukotriene A4 Hydrolase Genotype[NCT03100786] | Phase 3 | 640 participants (Anticipated) | Interventional | 2018-02-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aspirin and Meningitis, Tuberculous
| Article | Year |
|---|---|
Advances in the Diagnosis and Management of Tubercular Meningitis in Children.
Topics: Antitubercular Agents; Aspirin; Child; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Molecul | 2020 |
6 trials available for aspirin and Meningitis, Tuberculous
| Article | Year |
|---|---|
Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial.
Topics: Adolescent; Adult; Antitubercular Agents; Aspirin; Clinical Trials, Phase III as Topic; HIV Infectio | 2022 |
A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial.
Topics: Antitubercular Agents; Aspirin; HIV; HIV Infections; Humans; Linezolid; Rifampin; Treatment Outcome; | 2023 |
A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial.
Topics: Antitubercular Agents; Aspirin; HIV; HIV Infections; Humans; Linezolid; Rifampin; Treatment Outcome; | 2023 |
A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial.
Topics: Antitubercular Agents; Aspirin; HIV; HIV Infections; Humans; Linezolid; Rifampin; Treatment Outcome; | 2023 |
A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial.
Topics: Antitubercular Agents; Aspirin; HIV; HIV Infections; Humans; Linezolid; Rifampin; Treatment Outcome; | 2023 |
Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis.
Topics: Adult; Antitubercular Agents; Aspirin; Dexamethasone; Double-Blind Method; Female; Humans; Inflammat | 2019 |
Safety and efficacy of levofloxacin versus rifampicin in tuberculous meningitis: an open-label randomized controlled trial.
Topics: Adolescent; Adult; Aged; Antitubercular Agents; Aspirin; Drug Therapy, Combination; Ethambutol; Fema | 2014 |
Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female; Fo | 2010 |
Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female; Fo | 2010 |
Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female; Fo | 2010 |
Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Female; Fo | 2010 |
The role of aspirin in childhood tuberculous meningitis.
Topics: Anti-Inflammatory Agents; Aspirin; Child, Preschool; Dose-Response Relationship, Drug; Female; Follo | 2011 |
The role of aspirin in childhood tuberculous meningitis.
Topics: Anti-Inflammatory Agents; Aspirin; Child, Preschool; Dose-Response Relationship, Drug; Female; Follo | 2011 |
The role of aspirin in childhood tuberculous meningitis.
Topics: Anti-Inflammatory Agents; Aspirin; Child, Preschool; Dose-Response Relationship, Drug; Female; Follo | 2011 |
The role of aspirin in childhood tuberculous meningitis.
Topics: Anti-Inflammatory Agents; Aspirin; Child, Preschool; Dose-Response Relationship, Drug; Female; Follo | 2011 |
3 other studies available for aspirin and Meningitis, Tuberculous
| Article | Year |
|---|---|
Can aspirin help?
Topics: Adult; Aspirin; Double-Blind Method; HIV; Humans; Stroke; Tuberculosis, Meningeal | 2018 |
[RESULTS OF THE TREATMENT OF TUBERCULOSIS MENINGITIS IN CHILDREN USING HORMONAL PREPARATIONS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aspirin; Child; Humans; Streptomycin; Tubercul | 1964 |
Coagulant and fibrinolytic status in tuberculous meningitis.
Topics: Aspirin; Blood Coagulation; Child; Child, Preschool; Fibrinolysis; Humans; Infant; Platelet Count; T | 2007 |