aspirin and Melena studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
" We counted and trended reports to FAERS in which aspirin was associated with anaphylaxis or anaphylaxis followed by death."	4.12	Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database. ( Guo, Y; Ren, W; Wang, W, 2022)
"A comparison of aspirin and acetaminophen consumption in 346 matched pairs of patients with hematemesis and melena and general population control subjects has shown associations between intake of both drugs and bleeding."	3.66	Analgesic intake and the risk of acute upper gastrointestinal bleeding. ( Coggon, D; Langman, MJ; Spiegelhalter, D, 1983)
"Approaches to the treatment of acute coronary syndrome in patients with thrombocytopenia might be better directed toward the evaluation of platelet function rather than toward absolute platelet count, and the risk-benefit equation of invasive procedures and antithrombotic therapies may need to incorporate this information."	1.36	Antiplatelet therapy and percutaneous coronary intervention in patients with acute coronary syndrome and thrombocytopenia. ( Bathina, JD; Daher, IN; Durand, JB; Iliescu, C; Yusuf, SW, 2010)
"Gastroduodenal ulcers were found in 94 (44%) of the patients; two thirds of the users and one third of the non-users."	1.29	[Use of acetylsalicylic acid and other antiphlogistics in hematemesis/melena]. ( Aabakken, L; Breckan, RK, 1994)
" However, because of the inability to augment iron absorption to compensate for blood loss, it would be inadvisable for the patient with a partial gastrectomy to take a high dosage of aspirin for long periods of time, unless aspirin-induced blood loss is measured and shown to be very low."	1.25	Role of occult blood loss in anaemia after partial gastrectomy. ( Baird, IM; Nasser, SS; St John, DJ, 1970)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (84.91)	18.7374
1990's	4 (7.55)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (5.66)	24.3611
2020's	1 (1.89)	2.80

Authors	Studies
Ren, W	1
Wang, W	1
Guo, Y	1
Mousavi, M	1
Salehimarzijarani, B	1
Dadvar, Z	1
Jalalay, NY	1
Valizadeh, N	1
Sotoudeh, H	1
Zali, M	1
Telaku, S	1
Kraja, B	1
Qirjako, G	1
Prifti, S	1
Fejza, H	1
Yusuf, SW	1
Iliescu, C	1
Bathina, JD	1
Daher, IN	1
Durand, JB	1
SECRETAN, P	1
KHOSLA, SN	1
SCHWIETZER, CH	1
JENNINGS, GH	1
Langman, MJ	5
Coggon, D	2
Spiegelhalter, D	2
Booker, JA	1
Dirksen, A	1
Rasmussen, SN	1
Manthorpe, R	1
Wraight, EP	1
Seaman, MJ	1
Galanda, V	1
Visnovský, P	1
Buchanec, J	1
Ridolfo, AS	1
Crabtree, RE	1
Johnson, DW	1
Rockhold, FW	1
Walker, AM	1
Jick, H	1
Breckan, RK	1
Aabakken, L	1
Kelly, JP	1
Kaufman, DW	1
Jurgelon, JM	1
Sheehan, J	1
Koff, RS	1
Shapiro, S	1
Oshima, T	1
Cohen, MM	1
Shirley, E	1
Falaiye, JM	1
Odutola, TA	1
Rossouw, JE	1
Clarke, M	1
Davis, M	2
Williams, R	1
Domellöf, L	1
Sönne, B	1
John, DJ	1
Holman, RA	1
Gough, KR	1
Gartell, P	1
Britton, DC	1
Smith, RB	1
Aluwihare, AP	1
Karalliedde, LD	1
Jacobsen, CD	1
Bouchier, IA	1
Williams, HS	1
Dobbing, J	1
Leonards, JR	1
Levy, G	1
Neuwirtová, R	1
Setková, O	1
Reinisová, J	1
Chrzová, V	1
Johnston, SJ	1
Jones, PF	1
Kyle, J	1
Needham, CD	1
Beirne, JA	1
Bianchine, JR	1
Johnson, PC	1
Wortham, GF	1
Timaffy, M	1
Búzás, J	1
Hill, HF	1
Hill, AG	1
Mowat, AG	1
Ansell, BM	1
Mathews, JA	1
Seifert, MH	1
Gumpel, JM	1
Christie, GA	1
Stephens, FO	1
Milverton, EJ	1
Hambly, CK	1
van der Ven, EK	1
Nand, UP	1
Horwich, L	1
Evans, DA	1
McConnell, RB	1
Donohoe, WT	1
Thune, S	1
Valman, HB	1
Parry, DJ	1
Coghill, NF	1
Tudhope, GR	1
Baird, IM	1
St John, DJ	1
Nasser, SS	1
Touchard, P	1
Guimbretière, J	1
Cooke, AR	1
Saldanha, VF	1
Havard, CW	1
Jabbari, M	1
Valberg, LS	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309]				30 participants (Anticipated)	Interventional	2006-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Gastric mucosal damage by aspirin. CRC critical reviews in toxicology, 1975, Volume: 3, Issue:3 Topics: Anemia, Hypochromic; Animals; Aspirin; Cats; Dogs; Ferrets; Gastric Juice; Gastric Mucins; Gastric M	1975
Aspirin, other anti-inflammatory drugs and haematemesis and melaena. Agents and actions. Supplements, 1988, Volume: 25 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Hematemesis; Humans; Melena; United Kingdom; Unite	1988
Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding. Gut, 1970, Volume: 11, Issue:7 Topics: Alcohol Drinking; Animals; Ascorbic Acid Deficiency; Aspirin; Gastrointestinal Hemorrhage; Hematemes	1970

Article	Year
Fecal blood loss caused by two differently microencapsulated acetylsalicylic acid preparations in patients with rheumatoid arthritis. A prospective crossover study. Scandinavian journal of rheumatology, 1982, Volume: 11, Issue:3 Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Delayed-Action Preparations;	1982
Reduced faecal blood loss in patients receiving choline magnesium trisalicylate ('Trilisate') when compared with aspirin. Current medical research and opinion, 1983, Volume: 8, Issue:5 Topics: Adolescent; Adult; Aspirin; Choline; Humans; Male; Melena; Salicylates	1983
Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents. The Journal of rheumatology. Supplement, 1980, Volume: 6 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Clinical Trials as Topic; Do	1980
Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product. Lancet (London, England), 1996, Nov-23, Volume: 348, Issue:9039 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Buffers; Case-Control Stu	1996
Mucosal cytoprotection by prostaglandin E2. Lancet (London, England), 1978, Dec-09, Volume: 2, Issue:8102 Topics: Administration, Oral; Adult; Aspirin; Clinical Trials as Topic; Drug Antagonism; Gastric Mucosa; Hor	1978
Determination of faecal blood-loss after combined alcohol and sodium-acetylsalicylate intake. Lancet (London, England), 1969, Jan-25, Volume: 1, Issue:7587 Topics: Aspirin; Buffers; Chromium Isotopes; Clinical Trials as Topic; Ethanol; Gastric Mucosa; Gastrointest	1969
Faecal blood-loss after sodium acetylsalicylate taken with alcohol. Lancet (London, England), 1969, Mar-08, Volume: 1, Issue:7593 Topics: Aspirin; Clinical Trials as Topic; Ethanol; Gastrointestinal Hemorrhage; Humans; Melena; Placebos	1969
Naproxen. A new non-hormonal anti-inflammatory agent. Studies in rheumatoid arthritis. Annals of the rheumatic diseases, 1974, Volume: 33, Issue:1 Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dys	1974
The effect of food on aspirin induced gastro-intestinal blood loss. Digestion, 1968, Volume: 1, Issue:5 Topics: Aspirin; Chromium Isotopes; Clinical Trials as Topic; Feces; Food; Gastrointestinal Hemorrhage; Huma	1968
Safprin and gastrointestinal bleeding. The British journal of clinical practice, 1971, Volume: 25, Issue:4 Topics: Adult; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Melena; Tablets, Enteric-Coated	1971

aspirin and Melena

Research Excerpts

Research

Studies (53)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database. Computational and mathematical methods in medicine, 2022, Volume: 2022 Topics: Adverse Drug Reaction Reporting Systems; Anaphylaxis; Aspirin; Duodenal Ulcer; Humans; Melena; Unite	2022
Relationship between continuous use of low-dose enteric-coated aspirin and gastrointestinal injuries in patients with gastrointestinal hemorrhage. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2013, Volume: 24, Issue:2 Topics: Aspirin; Case-Control Studies; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastrointestinal	2013
Clinical outcomes of nonvariceal upper gastrointestinal bleeding in Kosova. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25 Suppl 1 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An	2014
Antiplatelet therapy and percutaneous coronary intervention in patients with acute coronary syndrome and thrombocytopenia. Texas Heart Institute journal, 2010, Volume: 37, Issue:3 Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogr	2010
[Gastrointestinal hemorrhage after salicylic acid therapy in peptic ulcer of long duration]. Praxis, 1955, Sep-15, Volume: 44, Issue:37 Topics: Aspirin; Gastrointestinal Hemorrhage; Humans; Melena; Peptic Ulcer; Salicylic Acid	1955
ASPIRIN-INDUCED HAEMATEMESIS. Journal of the Indian Medical Association, 1964, Oct-01, Volume: 43 Topics: Aspirin; Gastrointestinal Hemorrhage; Hematemesis; Hemorrhage; Humans; Melena; Toxicology	1964
[THE SALTS OF ACETYLSALICYLIC ACID ARE ALSO DANGEROUS]. Therapie der Gegenwart, 1964, Volume: 103 Topics: Anemia; Anemia, Hypochromic; Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Melena; Salts	1964
CAUSAL INFLUENCES IN HAEMATEMESIS AND MELAENA. Gut, 1965, Volume: 6 Topics: Alcoholic Beverages; Arteriosclerosis; Aspirin; Blood Group Antigens; Duodenal Ulcer; Genetics, Medi	1965
Analgesic intake and the risk of acute upper gastrointestinal bleeding. The American journal of medicine, 1983, Jun-14, Volume: 74, Issue:6A Topics: Acetaminophen; Analgesics; Aspirin; Female; Gastrointestinal Hemorrhage; Hematemesis; Humans; Male;	1983
Haematemesis and melaena in the elderly. Age and ageing, 1984, Volume: 13, Issue:1 Topics: Aged; Alcohol Drinking; Anti-Inflammatory Agents; Aspirin; Esophagitis; Female; Gastritis; Hematemes	1984
[Hematemesis and melena in children after administration of salicylates (author's transl)]. Bratislavske lekarske listy, 1981, Volume: 76, Issue:3 Topics: Aspirin; Child; Female; Gastrointestinal Hemorrhage; Hematemesis; Humans; Infant; Male; Melena	1981
Aspirin, paracetamol, and haematemesis and melaena. Gut, 1982, Volume: 23, Issue:4 Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Female; Hematemesis; Humans; Male; Melena; Middle A	1982
Predictors of bleeding during heparin therapy. JAMA, 1980, Sep-12, Volume: 244, Issue:11 Topics: Adult; Aged; Alcohol Drinking; Aspirin; Dose-Response Relationship, Drug; Epistaxis; Female; Hematom	1980
[Use of acetylsalicylic acid and other antiphlogistics in hematemesis/melena]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1994, Jan-30, Volume: 114, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dyspepsia; Female; Hemate	1994
[Predictive factors for development of hemolytic uremic syndrome (HUS) and early intensive treatments for prevention of HUS enterohemorrhagic Escherichia coli infection]. The Japanese journal of antibiotics, 1997, Volume: 50, Issue:11 Topics: Abdominal Pain; Adolescent; Age Factors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroi	1997
A review of papers purporting to show a cause-and-effect relationship between aspirin ingestion and massive gastrointestinal haemorrhage. Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 7 Topics: Aspirin; Gastrointestinal Hemorrhage; Hematemesis; Humans; Melena; Time Factors	1977
The economic potential and the role of aspirin and alcohol ingestion in relation to haematemesis and meleana. Nigerian medical journal : journal of the Nigeria Medical Association, 1978, Volume: 8, Issue:6 Topics: Adult; Aged; Aspirin; Ethanol; Female; Gastrointestinal Hemorrhage; Hematemesis; Humans; Male; Melen	1978
Occult gastrointestinal bleeding due to aspirin: comparison of two compounds. Rheumatology and rehabilitation, 1976, Volume: 15, Issue:1 Topics: Aspirin; Chromium Radioisotopes; Erythrocytes; Gastrointestinal Hemorrhage; Humans; Melena; Occult B	1976
[Serum salicylates in gastrointestinal hemorrhage]. Lakartidningen, 1976, Apr-14, Volume: 73, Issue:16 Topics: Acute Disease; Adolescent; Adult; Aged; Aspirin; Female; Gastrointestinal Hemorrhage; Hematemesis; H	1976
Value of a centralised approach in the management of haematemesis and melaena: experience in a district general hospital. Gut, 1990, Volume: 31, Issue:5 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Femal	1990
Leiomyoma of the duodenum presenting with haemorrhage after aspirin ingestion. The Ceylon medical journal, 1988, Volume: 33, Issue:1 Topics: Adult; Aspirin; Duodenal Neoplasms; Female; Hematemesis; Humans; Leiomyoma; Melena	1988
[Acetylsalicylic acid]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1986, Jun-20, Volume: 106, Issue:17-18 Topics: Aged; Aspirin; Humans; Male; Melena; Substance-Related Disorders	1986
Faecal blood-loss after sodium acetylsalicylate taken with alcohol. Lancet (London, England), 1969, Jul-05, Volume: 2, Issue:7610 Topics: Aspirin; Drug Synergism; Ethanol; Gastrointestinal Hemorrhage; Hematemesis; Humans; Melena; Occult B	1969
Effect of pharmaceutical formulation on gastrointestinal bleeding from aspirin tablets. Archives of internal medicine, 1972, Volume: 129, Issue:3 Topics: Administration, Oral; Adult; Antacids; Aspirin; Buffers; Chromium Isotopes; Female; Gastric Acidity	1972
[Gastrointestinal blood loss in various iron deficiency anemias]. Vnitrni lekarstvi, 1973, Volume: 19, Issue:4 Topics: Anemia, Hypochromic; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Melena	1973
Epidemiology and course of gastrointestinal haemorrhage in North-east Scotland. British medical journal, 1973, Sep-29, Volume: 3, Issue:5882 Topics: Adult; Aged; Alcohol Drinking; Aspirin; Blood Group Antigens; Duodenal Ulcer; Female; Gastritis; Gas	1973
Letter: Naproxen (naprosyn) and gastrointestinal haemorrhage. British medical journal, 1974, Apr-06, Volume: 2, Issue:5909 Topics: Acetanilides; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Blood Transfusion; Female; Gastritis;	1974
Gastrointestinal blood loss caused by tolmetin, aspirin, and indomethacin. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:5 Part 1 Topics: Adult; Anti-Inflammatory Agents; Aspirin; Benzoates; Chromium Radioisotopes; Diet; Female; Gastroint	1974
[Recurrent gastric hemorrhage caused by salicylic acid]. Orvosi hetilap, 1974, Dec-29, Volume: 115, Issue:52 Topics: Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans; Male; Melena	1974
A case study: haematemesis and melaena following aspirin administration. The Nursing journal of India, 1970, Volume: 61, Issue:10 Topics: Aspirin; Hematemesis; Melena; Nursing	1970
ABO blood groups in gastric bleeding. Gut, 1966, Volume: 7, Issue:6 Topics: ABO Blood-Group System; Adult; Aspirin; Blood Group Antigens; Duodenal Ulcer; Female; Gastric Mucosa	1966
[Gastrointestinal bleeding and salicylates. A comparative study between acetylsalicylic acid and salicylsalicylic acid]. Nordisk medicin, 1968, Mar-14, Volume: 79, Issue:11 Topics: Adult; Aged; Aspirin; Feces; Female; Gastrointestinal Hemorrhage; Humans; Male; Melena; Middle Aged;	1968
Lesions associated with gastroduodenal haemorrhage, in relation to aspirin intake. British medical journal, 1968, Dec-14, Volume: 4, Issue:5632 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans;	1968
Discussion on clinical trials of the fenamates. Annals of physical medicine, 1966, Volume: Suppl Topics: Analgesia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Central Nervous System; Flufena	1966
Comparison of flufenamic acid with aspirin and paracetamol in terms of gastrointestinal blood loss. Annals of physical medicine, 1966, Volume: Suppl Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chromium Isotopes; Fe	1966
Role of occult blood loss in anaemia after partial gastrectomy. Gut, 1970, Volume: 11, Issue:1 Topics: Adult; Aged; Anemia, Hypochromic; Aspirin; Female; Gastritis; Gastrointestinal Hemorrhage; Hemoglobi	1970
Susceptibility to aspirin bleeding. British medical journal, 1970, May-23, Volume: 1, Issue:5707 Topics: Alcohols; Anemia, Hypochromic; Aspirin; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage;	1970
[Drug cytopenia with active antibodies in the presence of acetyl-salicylic acid and niflumic acid]. Revue francaise de transfusion, 1969, Volume: 12, Issue:1 Topics: Adenine; Adult; Analgesics; Antibodies; Antigens; Aspirin; Blood Group Antigens; Blood Transfusion;	1969
Aspirin and gastrointestinal bleeding. Australasian annals of medicine, 1970, Volume: 19, Issue:2 Topics: Aspirin; Chronic Disease; Female; Gastrointestinal Hemorrhage; Humans; Melena; Stomach Ulcer	1970
Role of acid secretion in aspirin-induced gastric mucosal injury. Canadian Medical Association journal, 1970, Jan-31, Volume: 102, Issue:2 Topics: Achlorhydria; Adult; Aged; Aspirin; Biopsy; Blood Coagulation Tests; Female; Gastric Juice; Gastric	1970