aspirin has been researched along with Melanoma in 49 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of aspirin on melanoma are unclear, with studies reporting conflicting results." | 9.51 | Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial. ( Adler, NR; Chan, AT; Gibbs, P; Haydon, A; Mar, VJ; McLean, C; Orchard, SG; Rodriguez, LM; Wolfe, R; Woods, RL; Yan, MK, 2022) |
| "In an attempt to increase the antitumor effect of cisplatin (50 mg/m2) and dacarbazine (350 mg/m2), each repeated on days 1 to 3 every 4 weeks in patients with metastatic melanoma, tamoxifen was added to the regimen." | 9.07 | High-dose cisplatin with dacarbazine and tamoxifen in the treatment of metastatic melanoma. ( Buzaid, AC; Durivage, HJ; Murren, JR, 1991) |
| " We conducted a prospective randomized trial of alpha-interferon given with or without indomethacin to patients with malignant melanoma to determine what effect, if any, indomethacin might have on the toxic, immunomodulatory, and therapeutic properties of interferon in this disease." | 9.06 | Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. ( Clark, JW; Crum, E; Hawkins, MJ; Jones, MJ; Longo, DL; McKnight, JE; Miller, RL; Smith, JW; Steis, RG; Urba, WJ, 1989) |
| "The association between hypertension and melanoma is unclear, and previous analyses of data from the ASPirin in Reducing Events in the Elderly (ASPREE) study demonstrated a reduced number of invasive melanoma events amongst aspirin-exposed hypertensive individuals." | 8.12 | Association between hypertension and cutaneous melanoma, and the effect of aspirin: extended follow-up of a large randomised controlled trial. ( Adler, NR; Chan, AT; Gibbs, P; Haydon, A; Mar, VJ; McLean, C; Orchard, SG; Rodríguez, LM; Wolfe, R; Woods, RL; Yan, MK, 2022) |
| "Determine whether aspirin confers longer survival in patients with melanoma." | 7.88 | Postdiagnosis aspirin use and overall survival in patients with melanoma. ( Lautenschlaeger, T; Li, H; Li, Z; Rachidi, S; Wallace, K, 2018) |
| "Antiproliferative signaling of combinations of the nonsteroidal anti-inflammatory drug acetylsalicylic acid (aspirin) and indole-3-carbinol (I3C), a natural indolecarbinol compound derived from cruciferous vegetables, was investigated in human melanoma cells." | 7.83 | Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. ( Aronchik, I; Firestone, GL; Matthew, S; Poindexter, KM, 2016) |
| "In the current work, we investigated the biochemical toxicity of acetylsalicylic acid (ASA; Aspirin) in human melanoma cell lines using tyrosinase enzyme as a molecular cancer therapeutic target." | 7.74 | Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines. ( Moridani, MY; Vad, NM; Yount, G, 2008) |
| "Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative." | 5.56 | Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis. ( Abou-Kheir, W; Ausina, P; Branco, JR; Demaria, TM; Esteves, AM; Leandro, JGB; Mendonça, APM; Ochioni, AC; Oliveira, MF; Palhano, FL; Sola-Penna, M; Zancan, P, 2020) |
| "The effects of aspirin on melanoma are unclear, with studies reporting conflicting results." | 5.51 | Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial. ( Adler, NR; Chan, AT; Gibbs, P; Haydon, A; Mar, VJ; McLean, C; Orchard, SG; Rodriguez, LM; Wolfe, R; Woods, RL; Yan, MK, 2022) |
| "Melanoma is one of the most aggressive forms of cancer with a continuously growing incidence worldwide and is usually resistant to chemotherapy agents, which is due in part to a strong resistance to apoptosis." | 5.43 | Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. ( Badran, B; Fidanzi-Dugas, C; Hassan, L; Liagre, B; Limami, Y; Martin, F; Pinon, A; Seeman, J; Simon, A, 2016) |
| "In an attempt to increase the antitumor effect of cisplatin (50 mg/m2) and dacarbazine (350 mg/m2), each repeated on days 1 to 3 every 4 weeks in patients with metastatic melanoma, tamoxifen was added to the regimen." | 5.07 | High-dose cisplatin with dacarbazine and tamoxifen in the treatment of metastatic melanoma. ( Buzaid, AC; Durivage, HJ; Murren, JR, 1991) |
| " We conducted a prospective randomized trial of alpha-interferon given with or without indomethacin to patients with malignant melanoma to determine what effect, if any, indomethacin might have on the toxic, immunomodulatory, and therapeutic properties of interferon in this disease." | 5.06 | Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. ( Clark, JW; Crum, E; Hawkins, MJ; Jones, MJ; Longo, DL; McKnight, JE; Miller, RL; Smith, JW; Steis, RG; Urba, WJ, 1989) |
| "The association between hypertension and melanoma is unclear, and previous analyses of data from the ASPirin in Reducing Events in the Elderly (ASPREE) study demonstrated a reduced number of invasive melanoma events amongst aspirin-exposed hypertensive individuals." | 4.12 | Association between hypertension and cutaneous melanoma, and the effect of aspirin: extended follow-up of a large randomised controlled trial. ( Adler, NR; Chan, AT; Gibbs, P; Haydon, A; Mar, VJ; McLean, C; Orchard, SG; Rodríguez, LM; Wolfe, R; Woods, RL; Yan, MK, 2022) |
| "Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms." | 3.96 | Aspirin Induces Mitochondrial Ca ( Ando, T; Fujikawa, I; Ochiai, T; Suzuki-Karasaki, M; Suzuki-Karasaki, Y, 2020) |
| "Determine whether aspirin confers longer survival in patients with melanoma." | 3.88 | Postdiagnosis aspirin use and overall survival in patients with melanoma. ( Lautenschlaeger, T; Li, H; Li, Z; Rachidi, S; Wallace, K, 2018) |
| " In a cross-sectional study of 787 patients with newly diagnosed clinical stage IB or II melanoma, we estimated odds ratios for the association of proinflammatory factors (high body mass index, diabetes, cardiovascular disease, hypertension, and smoking) or the use of anti-inflammatory medications (statins, aspirin, corticosteroids, and nonsteroidal anti-inflammatory drugs), with ulcerated primary melanoma using regression models and subgroup analyses to control for melanoma thickness and mitotic rate." | 3.85 | Associations of Statins and Diabetes with Diagnosis of Ulcerated Cutaneous Melanoma. ( Green, AC; Hughes, MCB; Khosrotehrani, K; Malt, M; Smith, D; Smithers, BM; van der Pols, JC; von Schuckmann, LA, 2017) |
| "Antiproliferative signaling of combinations of the nonsteroidal anti-inflammatory drug acetylsalicylic acid (aspirin) and indole-3-carbinol (I3C), a natural indolecarbinol compound derived from cruciferous vegetables, was investigated in human melanoma cells." | 3.83 | Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells. ( Aronchik, I; Firestone, GL; Matthew, S; Poindexter, KM, 2016) |
| " Factors reported to modify systemic inflammation (low vitamin D levels, high body mass index, use of aspirin or nonsteroidal anti-inflammatory drugs or smoking were tested as predictors of microscopic ulceration (in which primary tumors are inflamed) and melanoma-specific survival (MSS)." | 3.81 | 25-Hydroxyvitamin D2 /D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort. ( Bishop, DT; Chan, M; Davies, JR; Gascoyne, J; Haynes, S; Latheef, F; Newton-Bishop, JA; O'Donovan, C; Randerson-Moor, J; Waseem, S, 2015) |
| "Neither aspirin nor non-aspirin NSAID use was associated with a lower risk of melanoma, SCC, or BCC, even for women with high quantity, frequency, or duration of use." | 3.78 | Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses' Health Study. ( Alberts, DS; Feskanich, D; Han, J; Jeter, JM; Martinez, ME; Qureshi, AA, 2012) |
| " In this regard, we compared the effects of NONO-aspirin and a novel NONO-naproxen to those exerted by their respective parent NSAIDs on avidities of human melanoma M624 cells." | 3.78 | Effects of nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) on melanoma cell adhesion. ( Cheng, H; Lee, SH; Mollica, MY; Velázquez-Martínez, CA; Wang, L; Wu, S, 2012) |
| "In the current work, we investigated the biochemical toxicity of acetylsalicylic acid (ASA; Aspirin) in human melanoma cell lines using tyrosinase enzyme as a molecular cancer therapeutic target." | 3.74 | Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines. ( Moridani, MY; Vad, NM; Yount, G, 2008) |
| " The direct cytotoxicity of piroxicam indomethacin, and aspirin against 4 canine tumor cell lines (transitional cell carcinoma, squamous cell carcinoma, melanoma, and soft tissue sarcoma) was determined in short-term growth rate assays and in clonogenic assays." | 3.69 | Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells. ( Chan, TC; Knapp, DW; Kuczek, T; Park, B; Reagan, WJ, 1995) |
| "Melanoma is a treatment-resistant cancer of melanocytes." | 1.72 | The Challenge of Melanoma Chemoprevention. ( Athar, M; Elmets, CA; Slominski, A, 2022) |
| "UVR promotes skin cancer through multiple mechanisms, including induction of inflammation, oxidative stress, and DNA damage such as 8-oxoguanine and cyclobutane pyrimidine dimers." | 1.62 | Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo. ( Boucher, KM; Burd, CE; Florell, SR; Grossman, D; Kumar, D; Liu, T; Lum, D; Okwundu, N; Rahman, H; VanBrocklin, MW, 2021) |
| "Platelets also promoted cancer cell invasion in vitro." | 1.56 | Platelets disrupt vasculogenic mimicry by cancer cells. ( Bonder, CS; Cockshell, MP; Dale, BJ; Ebert, LM; Hyslop, SR; Josefsson, EC; Martini, C; Thompson, EJ; Woods, AE, 2020) |
| "Melanoma is the most aggressive and fatal type of skin cancer due to being highly proliferative." | 1.56 | Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis. ( Abou-Kheir, W; Ausina, P; Branco, JR; Demaria, TM; Esteves, AM; Leandro, JGB; Mendonça, APM; Ochioni, AC; Oliveira, MF; Palhano, FL; Sola-Penna, M; Zancan, P, 2020) |
| "Melanoma is one of the most aggressive forms of cancer with a continuously growing incidence worldwide and is usually resistant to chemotherapy agents, which is due in part to a strong resistance to apoptosis." | 1.43 | Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. ( Badran, B; Fidanzi-Dugas, C; Hassan, L; Liagre, B; Limami, Y; Martin, F; Pinon, A; Seeman, J; Simon, A, 2016) |
| "Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-promoting inflammation." | 1.42 | Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity. ( Acton, SE; Böttcher, JP; Chakravarty, P; Girotti, MR; Marais, R; Quezada, SA; Reis e Sousa, C; Rogers, N; Sahai, E; Snelgrove, KJ; van der Veen, AG; Zelenay, S, 2015) |
| " Interestingly, the acute toxic death could not be reached at the maximum administrable dose (5 g/kg)." | 1.42 | Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. ( Dong, H; Gao, Y; Jia, L; Li, T; Lu, Y; Ma, J; Shao, J; Tu, X; Wan, L; Wang, J; Xie, F; Xie, J; Xu, B; Xu, H; Zhang, T; Zhu, Y, 2015) |
| " Long-term use of NSAIDs, especially ASA, is associated with a significantly decreased risk of CM development." | 1.37 | Long-term use of nonsteroidal anti-inflammatory drugs decreases the risk of cutaneous melanoma: results of a United States case-control study. ( Atkins, MB; Curiel-Lewandrowski, C; Gomez, ML; Hollestein, LM; Nijsten, T; Stern, RS, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.29) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 5 (10.20) | 29.6817 |
| 2010's | 25 (51.02) | 24.3611 |
| 2020's | 9 (18.37) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Zhang, Y | 1 |
| Chen, S | 1 |
| Liu, W | 1 |
| Lin, Y | 1 |
| Zhang, H | 1 |
| Yu, F | 1 |
| Elmets, CA | 1 |
| Slominski, A | 1 |
| Athar, M | 1 |
| Yan, MK | 2 |
| Orchard, SG | 2 |
| Adler, NR | 2 |
| Wolfe, R | 2 |
| McLean, C | 2 |
| Rodriguez, LM | 2 |
| Woods, RL | 2 |
| Gibbs, P | 2 |
| Chan, AT | 2 |
| Haydon, A | 2 |
| Mar, VJ | 2 |
| Li, H | 3 |
| Zhang, L | 1 |
| Yang, F | 1 |
| Zhao, R | 1 |
| Li, X | 1 |
| Martini, C | 1 |
| Thompson, EJ | 1 |
| Hyslop, SR | 1 |
| Cockshell, MP | 1 |
| Dale, BJ | 1 |
| Ebert, LM | 1 |
| Woods, AE | 1 |
| Josefsson, EC | 1 |
| Bonder, CS | 1 |
| Rahman, H | 1 |
| Kumar, D | 1 |
| Liu, T | 1 |
| Okwundu, N | 1 |
| Lum, D | 1 |
| Florell, SR | 1 |
| Burd, CE | 1 |
| Boucher, KM | 1 |
| VanBrocklin, MW | 1 |
| Grossman, D | 2 |
| Fujikawa, I | 1 |
| Ando, T | 1 |
| Suzuki-Karasaki, M | 2 |
| Ochiai, T | 1 |
| Suzuki-Karasaki, Y | 1 |
| Ausina, P | 1 |
| Branco, JR | 1 |
| Demaria, TM | 1 |
| Esteves, AM | 1 |
| Leandro, JGB | 1 |
| Ochioni, AC | 1 |
| Mendonça, APM | 1 |
| Palhano, FL | 1 |
| Oliveira, MF | 1 |
| Abou-Kheir, W | 1 |
| Sola-Penna, M | 1 |
| Zancan, P | 1 |
| von Schuckmann, LA | 1 |
| Smith, D | 1 |
| Hughes, MCB | 1 |
| Malt, M | 1 |
| van der Pols, JC | 1 |
| Khosrotehrani, K | 1 |
| Smithers, BM | 1 |
| Green, AC | 1 |
| Rachidi, S | 1 |
| Wallace, K | 1 |
| Lautenschlaeger, T | 1 |
| Li, Z | 1 |
| Gaskins, M | 1 |
| Dittmann, M | 1 |
| Eisert, L | 1 |
| Werner, RN | 1 |
| Dressler, C | 1 |
| Löser, C | 1 |
| Nast, A | 1 |
| Orrell, KA | 2 |
| Cices, AD | 1 |
| Guido, N | 1 |
| Majewski, S | 1 |
| Ibler, E | 1 |
| Huynh, T | 1 |
| Rangel, SM | 1 |
| Laumann, AE | 1 |
| Martini, MC | 1 |
| Rademaker, AW | 2 |
| West, DP | 2 |
| Nardone, B | 2 |
| Lichtenberger, LM | 1 |
| Burge, S | 1 |
| Kim, K | 1 |
| Heo, YK | 1 |
| Chun, S | 1 |
| Kim, CH | 1 |
| Bian, Y | 1 |
| Bae, ON | 1 |
| Lee, MY | 1 |
| Lim, KM | 1 |
| Chung, JH | 1 |
| Hammami, MB | 1 |
| Gill, R | 1 |
| Thiruvengadam, N | 1 |
| Oh, DY | 1 |
| Beck, K | 1 |
| Mahadevan, U | 1 |
| Kattah, MG | 1 |
| Gamba, CA | 1 |
| Swetter, SM | 2 |
| Stefanick, ML | 1 |
| Kubo, J | 2 |
| Desai, M | 2 |
| Spaunhurst, KM | 1 |
| Sinha, AA | 1 |
| Asgari, MM | 1 |
| Sturgeon, S | 1 |
| Tang, JY | 3 |
| Ally, MS | 1 |
| Pilowsky, PM | 1 |
| Famenini, S | 2 |
| Young, LC | 1 |
| Goodman, JR | 1 |
| Newton-Bishop, JA | 1 |
| Davies, JR | 1 |
| Latheef, F | 1 |
| Randerson-Moor, J | 1 |
| Chan, M | 1 |
| Gascoyne, J | 1 |
| Waseem, S | 1 |
| Haynes, S | 1 |
| O'Donovan, C | 1 |
| Bishop, DT | 1 |
| Duan, L | 1 |
| Young, L | 1 |
| Zelenay, S | 1 |
| van der Veen, AG | 1 |
| Böttcher, JP | 1 |
| Snelgrove, KJ | 1 |
| Rogers, N | 1 |
| Acton, SE | 1 |
| Chakravarty, P | 1 |
| Girotti, MR | 1 |
| Marais, R | 1 |
| Quezada, SA | 1 |
| Sahai, E | 1 |
| Reis e Sousa, C | 1 |
| Wan, L | 1 |
| Dong, H | 1 |
| Xu, H | 1 |
| Ma, J | 1 |
| Zhu, Y | 1 |
| Lu, Y | 1 |
| Wang, J | 1 |
| Zhang, T | 1 |
| Li, T | 1 |
| Xie, J | 1 |
| Xu, B | 1 |
| Xie, F | 1 |
| Gao, Y | 1 |
| Shao, J | 1 |
| Tu, X | 1 |
| Jia, L | 1 |
| Poindexter, KM | 1 |
| Matthew, S | 1 |
| Aronchik, I | 1 |
| Firestone, GL | 1 |
| Hassan, L | 1 |
| Pinon, A | 1 |
| Limami, Y | 1 |
| Seeman, J | 1 |
| Fidanzi-Dugas, C | 1 |
| Martin, F | 1 |
| Badran, B | 1 |
| Simon, A | 1 |
| Liagre, B | 1 |
| Pelster, MW | 1 |
| Yoo, S | 1 |
| Vad, NM | 1 |
| Yount, G | 1 |
| Moridani, MY | 1 |
| Joosse, A | 1 |
| Koomen, ER | 1 |
| Casparie, MK | 1 |
| Herings, RM | 1 |
| Guchelaar, HJ | 1 |
| Nijsten, T | 2 |
| Curiel-Lewandrowski, C | 1 |
| Gomez, ML | 1 |
| Hollestein, LM | 1 |
| Atkins, MB | 1 |
| Stern, RS | 1 |
| Jeter, JM | 1 |
| Han, J | 1 |
| Martinez, ME | 1 |
| Alberts, DS | 1 |
| Qureshi, AA | 1 |
| Feskanich, D | 1 |
| Cheng, H | 1 |
| Mollica, MY | 1 |
| Lee, SH | 2 |
| Wang, L | 1 |
| Velázquez-Martínez, CA | 1 |
| Wu, S | 1 |
| Khalifeh, MR | 1 |
| Redett, RJ | 1 |
| Robles-Díaz, G | 1 |
| Fastag, D | 1 |
| Levin, RI | 1 |
| Harpel, PC | 1 |
| Weil, D | 1 |
| Chang, TS | 1 |
| Rifkin, DB | 1 |
| Grohmann, PH | 1 |
| Porzsolt, F | 1 |
| Quirt, I | 1 |
| Miller, RG | 1 |
| Phillips, RA | 1 |
| Knapp, DW | 1 |
| Chan, TC | 1 |
| Kuczek, T | 1 |
| Reagan, WJ | 1 |
| Park, B | 1 |
| Maria, DA | 1 |
| Ribeiro, OG | 1 |
| Pizzocaro, KF | 1 |
| De Franco, M | 1 |
| Cabrera, WK | 1 |
| Starobinas, N | 1 |
| Gallois, V | 1 |
| Siqueira, M | 1 |
| Seman, M | 1 |
| Ibañez, OM | 1 |
| Buzaid, AC | 1 |
| Murren, JR | 1 |
| Durivage, HJ | 1 |
| Raub, W | 1 |
| Miller, RL | 1 |
| Steis, RG | 1 |
| Clark, JW | 1 |
| Smith, JW | 1 |
| Crum, E | 1 |
| McKnight, JE | 1 |
| Hawkins, MJ | 1 |
| Jones, MJ | 1 |
| Longo, DL | 1 |
| Urba, WJ | 1 |
| Talmadge, JE | 1 |
| Bowersox, O | 1 |
| Tribble, H | 1 |
| Shepard, HM | 1 |
| Liggitt, D | 1 |
| Creagan, ET | 1 |
| Buckner, JC | 1 |
| Hahn, RG | 1 |
| Richardson, RR | 1 |
| Schaid, DJ | 1 |
| Kovach, JS | 1 |
| Silverstein, MJ | 1 |
| DeKernion, J | 1 |
| Morton, DL | 1 |
| Gasic, GJ | 1 |
| Gasic, TB | 1 |
| Galanti, N | 1 |
| Johnson, T | 1 |
| Murphy, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aspirin in Reducing Events in the Elderly[NCT01038583] | 19,114 participants (Actual) | Observational | 2010-01-31 | Active, not recruiting | |||
| [NCT00000611] | Phase 3 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for aspirin and Melanoma
| Article | Year |
|---|---|
Impact of concomitant medications on the efficacy of immune checkpoint inhibitors: an umbrella review.
Topics: Analgesics, Opioid; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Esophag | 2023 |
Aspirin use and melanoma risk: a review of the literature.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Humans; Melanoma; Skin Ne | 2014 |
Aspirin and other NSAIDs as chemoprevention agents in melanoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Chemoprevention; Hu | 2014 |
The management of patients on anticoagulants prior to cutaneous surgery: case report of a thromboembolic complication, review of the literature, and evidence-based recommendations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Atrial Fibrillation; Brain Damage, | 2006 |
[Cancer of the pancreas. Epidemiology and risk factors].
Topics: Adenomatous Polyposis Coli; Age Factors; Aged; Aspirin; Breast Neoplasms; Diabetes Mellitus, Type 2; | 2007 |
3 trials available for aspirin and Melanoma
| Article | Year |
|---|---|
Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial.
Topics: Aged; Aspirin; Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Male; Melanoma; Me | 2022 |
High-dose cisplatin with dacarbazine and tamoxifen in the treatment of metastatic melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Cisplatin; Dacarbazine; Drug E | 1991 |
Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Female; Humans; Indomethacin; Interferon Type I; Kil | 1989 |
41 other studies available for aspirin and Melanoma
| Article | Year |
|---|---|
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Humans; Melanoma; Mitogen-Activa | 2022 |
The Challenge of Melanoma Chemoprevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemoprevention; Cyclooxygenase 2; Humans; Melanom | 2022 |
Association between hypertension and cutaneous melanoma, and the effect of aspirin: extended follow-up of a large randomised controlled trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Follow-Up Studies; Humans; Melanoma; Melanom | 2022 |
Platelets disrupt vasculogenic mimicry by cancer cells.
Topics: Animals; Apoptosis; Aspirin; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Female; Male; Mela | 2020 |
Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; DNA Damage; Kerat | 2021 |
Aspirin Induces Mitochondrial Ca
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium; Calcium Channels, L-Type; Cell Line, Tumo | 2020 |
Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; | 2020 |
Associations of Statins and Diabetes with Diagnosis of Ulcerated Cutaneous Melanoma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Sectio | 2017 |
Postdiagnosis aspirin use and overall survival in patients with melanoma.
Topics: Academic Medical Centers; Adult; Aged; Analysis of Variance; Aspirin; Cohort Studies; Confidence Int | 2018 |
Management of antithrombotic agents in dermatologic surgery before and after publication of the corresponding German evidence-based guideline.
Topics: Administration, Oral; Ambulatory Surgical Procedures; Aspirin; Biopsy; Clopidogrel; Evidence-Based M | 2018 |
Malignant melanoma associated with chronic once-daily aspirin exposure in males: A large, single-center, urban, US patient population cohort study from the "Research on Adverse Drug events And Report" (RADAR) project.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Aspirin; Case-Control Studi | 2018 |
Aspirin use and the risk of malignant melanoma.
Topics: Aspirin; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Melanoma; Sk | 2019 |
Reply to: "Aspirin use and the risk of malignant melanoma".
Topics: Aspirin; Humans; Melanoma; Skin Neoplasms | 2019 |
Arsenic May Act as a Pro-Metastatic Carcinogen Through Promoting Tumor Cell-Induced Platelet Aggregation.
Topics: Animals; Arsenic; Aspirin; Blood Platelets; Cell Adhesion; Cell Line, Tumor; Melanoma; Metalloprotea | 2019 |
Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; As | 2019 |
Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Female; H | 2013 |
Role of aspirin and non-aspirin NSAIDs in preventing melanoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Melanoma; Randomized Controlled Trials as | 2013 |
Reply to Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Melanoma; White People | 2013 |
Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Melanoma; White People | 2013 |
Aspirin may lower melanoma risk.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Melanoma; Risk Factors; Skin Neoplasms; Wo | 2013 |
25-Hydroxyvitamin D2 /D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort.
Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ste | 2015 |
Aspirin use and melanoma: A UCLA pilot study.
Topics: Academic Medical Centers; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy, Needle; C | 2015 |
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Topics: Adaptive Immunity; Animals; Antibodies, Monoclonal; Antigens, CD; Aspirin; Cell Line, Tumor; Dendrit | 2015 |
Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Doxycycline; Drug Interactions; Fe | 2015 |
Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
Topics: Aspirin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Synergism; Gene Exp | 2016 |
Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells.
Topics: Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Drug Resis | 2016 |
Use of an Abdominal Binder to Minimize Postprocedural Complications After Cutaneous Surgery on the Trunk.
Topics: Abdomen; Aged; Anticoagulants; Aspirin; Bandages; Humans; Male; Melanoma; Postoperative Hemorrhage; | 2016 |
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Benzoquinones; Cel | 2008 |
Non-steroidal anti-inflammatory drugs and melanoma risk: large Dutch population-based case-control study.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Dat | 2009 |
Long-term use of nonsteroidal anti-inflammatory drugs decreases the risk of cutaneous melanoma: results of a United States case-control study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Case-Control | 2011 |
Non-steroidal anti-inflammatory drugs, acetaminophen, and risk of skin cancer in the Nurses' Health Study.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Basal Cell; Carcinoma, S | 2012 |
Effects of nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) on melanoma cell adhesion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Azo Compounds; Cell Adhesion; Cell Line | 2012 |
Aspirin inhibits vascular plasminogen activator activity in vivo. Studies utilizing a new assay to quantify plasminogen activator activity.
Topics: alpha-2-Antiplasmin; Aspirin; Female; Fibrinolysin; Humans; Kinetics; Male; Melanoma; Plasminogen Ac | 1984 |
Stimulation of human NK cell activity by cultured cells. II Ingestion of aspirin by blood donors suppresses induced NK activity.
Topics: Antibody-Dependent Cell Cytotoxicity; Aspirin; Blood Specimen Collection; Cell Line; Humans; Killer | 1981 |
Evaluation of in vitro cytotoxicity of nonsteroidal anti-inflammatory drugs against canine tumor cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Squamou | 1995 |
Resistance to melanoma metastases in mice selected for high acute inflammatory response.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Neoplasm; Antigens, Neoplasm; Aspirin; | 2001 |
From the National Institutes of Health.
Topics: Aspirin; Breast Neoplasms; Female; Fetal Diseases; Heart Defects, Congenital; Humans; Immunotherapy; | 1990 |
Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Bone Marrow; Cyclooxygenase Inhibi | 1987 |
An evaluation of recombinant leukocyte A interferon with aspirin in patients with metastatic renal cell cancer.
Topics: Anorexia; Aspirin; Carcinoma, Renal Cell; Combined Modality Therapy; Drug Synergism; Fatigue; Feedin | 1988 |
Malignant melanoma metastatic to the bladder. Regression following intratumor injection of BCG vaccine.
Topics: Aspirin; BCG Vaccine; Biopsy; Cystoscopy; Diphenhydramine; Humans; Immunotherapy; Male; Melanoma; Mi | 1974 |
Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease.
Topics: Adenocarcinoma; Animals; Aspirin; Blood Cell Count; Blood Platelets; Carcinoma; Cell Survival; Chrom | 1973 |