Page last updated: 2024-10-23

aspirin and Lymph Node Metastasis

aspirin has been researched along with Lymph Node Metastasis in 12 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"In an attempt to increase the antitumor effect of cisplatin (50 mg/m2) and dacarbazine (350 mg/m2), each repeated on days 1 to 3 every 4 weeks in patients with metastatic melanoma, tamoxifen was added to the regimen."9.07High-dose cisplatin with dacarbazine and tamoxifen in the treatment of metastatic melanoma. ( Buzaid, AC; Durivage, HJ; Murren, JR, 1991)
" Therefore, we examined the association between recent (1 year) prediagnostic use of aspirin (COX1/COX2 inhibitor), lymph node involvement at breast cancer diagnosis, and breast cancer-specific mortality."7.80Recent prediagnostic aspirin use, lymph node involvement, and 5-year mortality in women with stage I-III breast cancer: a nationwide population-based cohort study. ( Barron, TI; Bennett, K; Flahavan, EM; Sharp, L; Visvanathan, K, 2014)
"Aspirin and NSAIDs inhibit COX-2."5.37COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin. ( Chen, WY; Colditz, GA; Collins, L; Hankinson, SE; Holmes, MD; Schnitt, SJ; Tamimi, RM, 2011)
"In an attempt to increase the antitumor effect of cisplatin (50 mg/m2) and dacarbazine (350 mg/m2), each repeated on days 1 to 3 every 4 weeks in patients with metastatic melanoma, tamoxifen was added to the regimen."5.07High-dose cisplatin with dacarbazine and tamoxifen in the treatment of metastatic melanoma. ( Buzaid, AC; Durivage, HJ; Murren, JR, 1991)
" The present study investigated the effect of an authentic COX inhibitor, aspirin, on regional lymph node metastasis during the development of lung cancer in mice."3.80Aspirin reduces lung cancer metastasis to regional lymph nodes. ( Amano, H; Hosono, K; Ito, Y; Kitasato, H; Majima, M; Matsui, Y; Ogawa, F; Satoh, Y, 2014)
" Therefore, we examined the association between recent (1 year) prediagnostic use of aspirin (COX1/COX2 inhibitor), lymph node involvement at breast cancer diagnosis, and breast cancer-specific mortality."3.80Recent prediagnostic aspirin use, lymph node involvement, and 5-year mortality in women with stage I-III breast cancer: a nationwide population-based cohort study. ( Barron, TI; Bennett, K; Flahavan, EM; Sharp, L; Visvanathan, K, 2014)
"The injection of aspirin on lymph nodes caused necrosis and an increase of apoptosis after 24 hours and after seven days of treatment there was regeneration of the lymph nodes, with intense decrease of necrosis and a great elevation of apoptosis."3.78Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases. ( Batista, RP; Denadai, R; Saad-Hossne, R, 2012)
"Pretreatment of aspirin at non-toxic dose 0."1.48Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-κB/VCAM-1 pathway in human lymphatic endothelial cells. ( Jantaree, P; Koizumi, K; Lirdprapamongkol, K; Ngiwsara, L; Prangsaengtong, O; Svasti, J, 2018)
"Aspirin and NSAIDs inhibit COX-2."1.37COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin. ( Chen, WY; Colditz, GA; Collins, L; Hankinson, SE; Holmes, MD; Schnitt, SJ; Tamimi, RM, 2011)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's2 (16.67)29.6817
2010's8 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Prangsaengtong, O1
Jantaree, P1
Lirdprapamongkol, K1
Ngiwsara, L1
Svasti, J1
Koizumi, K1
Ogawa, F1
Amano, H1
Ito, Y1
Matsui, Y1
Hosono, K1
Kitasato, H1
Satoh, Y1
Majima, M1
Ljung, R1
Sennerstam, R1
Mattsson, F1
Auer, G1
Lagergren, J1
Barron, TI1
Flahavan, EM1
Sharp, L1
Bennett, K1
Visvanathan, K1
Holmes, MD1
Chen, WY1
Schnitt, SJ1
Collins, L1
Colditz, GA1
Hankinson, SE1
Tamimi, RM1
Lee, SH1
Shin, SJ1
Park, DI1
Kim, SE1
Hong, SP1
Hong, SN1
Yang, DH1
Lee, BI1
Kim, YH1
Kim, HS1
Yang, SK1
Kim, HJ2
Kim, SH1
Dhillon, PK1
Kenfield, SA1
Stampfer, MJ1
Giovannucci, EL1
Chan, JM1
Batista, RP1
Denadai, R1
Saad-Hossne, R1
Füessl, HS1
Yamamoto, H1
Itoh, F1
Fukushima, H1
Hinoda, Y1
Imai, K1
Yoshizaki, T1
Buzaid, AC1
Murren, JR1
Durivage, HJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Small Colorectal Polyp Removal Using Cold Endoscopic Mucosal Resection With Hot Endoscopic Mucosal Resection: a Pilot Study[NCT03000868]0 participants (Actual)Interventional2016-12-01Withdrawn (stopped due to No participants were enrolled.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for aspirin and Lymph Node Metastasis

ArticleYear
[Expression of pharyngeal- tumor- metastasis related genes and possibility of the gene therapy--Suppressive effects of aspirin on the tumor metastasis].
    Nihon Jibiinkoka Gakkai kaiho, 2001, Volume: 104, Issue:8

    Topics: Animals; Aspirin; Gene Expression; Genetic Therapy; Herpesvirus 4, Human; Humans; I-kappa B Proteins

2001

Trials

1 trial available for aspirin and Lymph Node Metastasis

ArticleYear
High-dose cisplatin with dacarbazine and tamoxifen in the treatment of metastatic melanoma.
    Cancer, 1991, Sep-15, Volume: 68, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Cisplatin; Dacarbazine; Drug E

1991

Other Studies

10 other studies available for aspirin and Lymph Node Metastasis

ArticleYear
Aspirin suppresses components of lymphangiogenesis and lymphatic vessel remodeling by inhibiting the NF-κB/VCAM-1 pathway in human lymphatic endothelial cells.
    Vascular medicine (London, England), 2018, Volume: 23, Issue:3

    Topics: Aspirin; Cell Movement; Cell Proliferation; Endothelial Cells; Humans; Lymphangiogenesis; Lymphatic

2018
Aspirin reduces lung cancer metastasis to regional lymph nodes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:1

    Topics: Animals; Aspirin; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Green Fluorescent Proteins; Lung

2014
Anticoagulant medication at time of needle biopsy for breast cancer in relation to risk of lymph node metastasis.
    International journal of cancer, 2014, Jul-01, Volume: 135, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Biopsy, Needle; Blood Coagulation; Blood Pl

2014
Recent prediagnostic aspirin use, lymph node involvement, and 5-year mortality in women with stage I-III breast cancer: a nationwide population-based cohort study.
    Cancer research, 2014, Aug-01, Volume: 74, Issue:15

    Topics: Aged; Aged, 80 and over; Aspirin; Breast Neoplasms; Cohort Studies; Cyclooxygenase Inhibitors; Femal

2014
COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin.
    Breast cancer research and treatment, 2011, Volume: 130, Issue:2

    Topics: Adult; Antineoplastic Agents; Aspirin; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breas

2011
[Korean guidelines for colonoscopic polypectomy].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2012, Volume: 59, Issue:2

    Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Polyps; Colonoscopy; Colorectal N

2012
Aspirin use after a prostate cancer diagnosis and cancer survival in a prospective cohort.
    Cancer prevention research (Philadelphia, Pa.), 2012, Volume: 5, Issue:10

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; California; Follow-Up Studies; Humans

2012
Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases.
    Acta cirurgica brasileira, 2012, Volume: 27, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aspirin; Drug Screening Assays, Antitumor; Germinal Cente

2012
[Before polyp removal. To stop or not to stop ASA?].
    MMW Fortschritte der Medizin, 2003, Sep-25, Volume: 145, Issue:39

    Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Polyps; Endoscopy; Ga

2003
Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability.
    International journal of cancer, 1999, Aug-20, Volume: 84, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Aspirin; Base Pair Mismatch; Carrier Proteins; Cyclooxygenase

1999