aspirin and Lupus Erythematosus, Systemic studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Research Excerpts

Excerpt	Relevance	Reference
"The pharmacologic effect of aspirin is suboptimal in 15% of patients with SLE but in none of the control subjects, and the suboptimal response was associated with metabolic syndrome, obesity, and higher CRP concentrations."	9.19	Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. ( Avalos, I; Chung, CP; Kawai, VK; Milne, GL; Oates, JA; Oeser, A; Solus, JF; Stein, CM, 2014)
"The use of low-dose aspirin and heparinoids has improved the pregnancy outcome in obstetric antiphospholipid syndrome (APS)."	8.93	The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and clinical judgment. ( Branch, DW; Hunt, BJ; Khamashta, M; Levy, RA; Middeldorp, S; Pavord, S; Roccatello, D; Ruiz-Irastorza, G; Schreiber, K; Sciascia, S; Tincani, A, 2016)
"We performed a meta-analysis to determine whether aspirin has a significant protective effect on risk of first thrombosis among patients with antiphospholipid antibodies (aPL+)."	8.90	Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis. ( Amoura, Z; Arnaud, L; Balasch, J; Cervera, R; Erkan, D; Forastiero, R; Lambert, M; Martinez-Zamora, MA; Mathian, A; Pengo, V; Ruffatti, A; Tektonidou, M; Wahl, D; Zuily, S, 2014)
"Hydroxychloroquine combined with low-dose aspirin can effectively improve the pregnancy outcomes of pregnant women with SLE by affecting the levels of T helper (Th) 2 and Th1 cytokines."	8.31	Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus. ( Li, Y; Li, YW; Zhang, HX; Zhang, N, 2023)
"Women with lupus have an increased risk of preeclampsia and preterm birth, and aspirin 81 mg/day is recommended as a preventative measure for preeclampsia."	7.91	Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study. ( Clowse, MEB; Eudy, AM; Myers, RA; Voora, D, 2019)
"Aspirin resistance may be associated with increased risk of adverse pregnancy outcomes including preeclampsia, premature delivery and delivery of SGA newborns."	7.77	Aspirin resistance may be associated with adverse pregnancy outcomes. ( Huras, H; Jach, R; Musiał, J; Reroń, A; Rytlewski, K; Undas, A; Wilczak, M; Wójtowicz, A, 2011)
"A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter."	7.75	Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. ( Koren, G, 2009)
"We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day."	7.74	Hydroxychloroquine-induced hyperpigmentation: the staining pattern. ( Ferringer, T; Lountzis, NI; Puri, PK; Tyler, W, 2008)
"After treatment the pregnancy wastage rate was 55% and 25% in the 2 groups respectively."	5.28	Pregnancy loss with phospholipid antibodies: improved outcome with aspirin containing treatment. ( Cameron, K; Gatenby, PA; Shearman, RP, 1989)
"In whole blood from 30 patients with systemic lupus erythematosus (SLE), 10 normal subjects, and 40 patients with active seropositive rheumatoid arthritis (RA), there were negative correlations between the hematocrit level and the ASA half-life in vitro: r = -0."	5.27	Patterns of in vitro aspirin hydrolysis rates in rheumatoid arthritis and systemic lupus erythematosus. ( Costello, PB; Green, FA, 1986)
"The pharmacologic effect of aspirin is suboptimal in 15% of patients with SLE but in none of the control subjects, and the suboptimal response was associated with metabolic syndrome, obesity, and higher CRP concentrations."	5.19	Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. ( Avalos, I; Chung, CP; Kawai, VK; Milne, GL; Oates, JA; Oeser, A; Solus, JF; Stein, CM, 2014)
"The objectives of this study are to examine the efficacy and safety of low-dose aspirin (LDA) vs LDA plus low-intensity warfarin (LDA + W) in the primary thrombosis prevention of aPL-positive patients with SLE and/or obstetric morbidity and the role of clinical and serological markers in the development of thrombosis."	5.19	Low-dose aspirin vs low-dose aspirin plus low-intensity warfarin in thromboprophylaxis: a prospective, multicentre, randomized, open, controlled trial in patients positive for antiphospholipid antibodies (ALIWAPAS). ( Aguirre, A; Akil, M; Amigo, MC; Bertolaccini, ML; Cuadrado, MJ; Egurbide, MV; Espinosa, G; Galindo, M; Gil, A; Gordon, C; Houssiau, F; Khamashta, MA; Martin, H; McHugh, N; Mico, L; Murru, V; Rahman, A; Ruiz-Irastorza, G; Seed, PT; Tektonidou, MG, 2014)
"The use of low-dose aspirin and heparinoids has improved the pregnancy outcome in obstetric antiphospholipid syndrome (APS)."	4.93	The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and clinical judgment. ( Branch, DW; Hunt, BJ; Khamashta, M; Levy, RA; Middeldorp, S; Pavord, S; Roccatello, D; Ruiz-Irastorza, G; Schreiber, K; Sciascia, S; Tincani, A, 2016)
"We performed a meta-analysis to determine whether aspirin has a significant protective effect on risk of first thrombosis among patients with antiphospholipid antibodies (aPL+)."	4.90	Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis. ( Amoura, Z; Arnaud, L; Balasch, J; Cervera, R; Erkan, D; Forastiero, R; Lambert, M; Martinez-Zamora, MA; Mathian, A; Pengo, V; Ruffatti, A; Tektonidou, M; Wahl, D; Zuily, S, 2014)
" Clinical trials have demonstrated that patients with antiphospholipid antibodies and venous thromboembolism should be treated with vitamin K antagonists (warfarin); that ischemic stroke may be treated with aspirin or warfarin; and that women with recurrent pregnancy loss should receive prophylactic-dose heparin and aspirin."	4.85	Antiphospholipid antibody syndrome. ( Lim, W, 2009)
" Among SLE group, lower birth weight and smaller gestational age were observed in SLE mothers with disease active during pregnancy, kidney involved, blood system involved and not taking Aspirin during pregnancy."	4.31	Association of preterm outcome with maternal systemic lupus erythematosus: a retrospective cohort study. ( Bei, F; Bu, J; Chen, X; Di, W; Hu, Y; Jiang, M; Sun, J; Wu, J; Ye, L, 2023)
"Hydroxychloroquine combined with low-dose aspirin can effectively improve the pregnancy outcomes of pregnant women with SLE by affecting the levels of T helper (Th) 2 and Th1 cytokines."	4.31	Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus. ( Li, Y; Li, YW; Zhang, HX; Zhang, N, 2023)
"(1) To assess the clinical utility of the adjusted global antiphospholipid syndrome score (aGAPSS) to predict new obstetric events during follow-up in primary obstetric antiphospholipid syndrome (POAPS) patients under standard-of-care treatment (SC) based on the use of low-dose aspirin (LDA) + heparin and (2) to study the risk of a first thrombotic event and to evaluate whether stratification according to this score could help to identify POAPS patients who would benefit from long-term thromboprophylaxis."	4.12	Clinical and therapeutic value of the adjusted Global Antiphospholipid Syndrome Score in primary obstetric antiphospholipid syndrome. ( Alijotas-Reig, J; Aranda, F; Belizna, C; de Larrañaga, G; Esteve-Valverde, E; Fernández-Romero, DS; Latino, JO; Peréz, SM; Udry, S; Wingeyer, SP, 2022)
"Women with lupus have an increased risk of preeclampsia and preterm birth, and aspirin 81 mg/day is recommended as a preventative measure for preeclampsia."	3.91	Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study. ( Clowse, MEB; Eudy, AM; Myers, RA; Voora, D, 2019)
"Aspirin resistance may be associated with increased risk of adverse pregnancy outcomes including preeclampsia, premature delivery and delivery of SGA newborns."	3.77	Aspirin resistance may be associated with adverse pregnancy outcomes. ( Huras, H; Jach, R; Musiał, J; Reroń, A; Rytlewski, K; Undas, A; Wilczak, M; Wójtowicz, A, 2011)
" Serous retinal detachments were confirmed using fluorescein and indocyanine green angiography."	3.76	OCT follow-up of systemic lupus erythematosus choroidopathy. ( Bouillet, L; Chiquet, C; Kouprianoff, S; Romanet, JP, 2010)
"A sudden hearing loss in a woman on aspirin has uncovered a frequently neglected toxicological parameter."	3.75	Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. ( Koren, G, 2009)
"We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day."	3.74	Hydroxychloroquine-induced hyperpigmentation: the staining pattern. ( Ferringer, T; Lountzis, NI; Puri, PK; Tyler, W, 2008)
"Authors describe a successful pregnancy outcome after prednisone and aspirin therapy in 19-year-old woman with systemic lupus erythematosus with the history of recurrent urinary tract infections, pericarditis and encephalitis."	3.71	[Course of pregnancy in a patient with systemic lupus erythematosus--case report]. ( Goluda, M; Jerzak, MM; Podwysocka, M; Prusek, W, 2002)
"This prospective study is an attempt to address the issues of whether or not antiphospholipid antibodies (aPL) constitute a significant risk factor for pregnancy in individuals with systemic lupus erythematosus (SLE) and whether or not combination therapy of high-dose prednisolone (PSL) and low-dose acetylsalicylic acid (ASA) offers efficient control."	3.69	A prospective study on pregnancy risk of antiphospholipid antibodies in association with systemic lupus erythematosus. ( Aoki, K; Hayashi, Y; Ogasawara, M, 1995)
" Immunoadsorbent plasmapheresis with a dextran sulphate column was used to remove lupus anticoagulant, anticardiolipin antibodies, and antibodies to DNA during her fourth pregnancy in combination with low doses of aspirin and prednisolone."	3.68	Immunoadsorbent plasmapheresis for a patient with antiphospholipid syndrome during pregnancy. ( Hashimoto, H; Hirose, S; Kobayashi, S; Mokuno, C; Tamura, N; Tsuda, H, 1992)
"A patient with systemic lupus erythematosus and elevated cardiolipin antibody levels was given low-dose aspirin therapy prior to and throughout her third pregnancy to minimize the risk of miscarriage."	3.68	Anticardiolipin syndrome, aspirin therapy and fetal malformation. ( Chakravarty, K; Merry, P, 1993)
"Since systemic lupus erythematosus (SLE) is associated with platelet activation and increased cardiovascular mortality, we compared thromboxane and prostacyclin biosynthesis in patients with SLE and control subjects, and measured inhibition of thromboxane excretion in aspirin-treated subjects."	2.73	Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus. ( Avalos, I; Borntrager, H; Chung, CP; Milne, GL; Morrow, JD; Oeser, A; Raggi, P; Solus, J; Stein, CM, 2007)
"Pregnancy was successfully carried out in 12/12 (100%) SLE-RSA patients with a mean Apgar score of 8."	2.73	Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. ( Cipriani, P; De Carolis, C; Fontana, L; Giacomelli, R; Greco, E; Kröegler, B; Perricone, C; Perricone, R, 2008)
"We studied 14 pregnant women with systemic lupus erythematosus (SLE), of whom six had detectable antiphospholipid antibodies."	2.67	Production of prostacyclin and thromboxane in lupus pregnancies: effect of small dose of aspirin. ( Julkunen, H; Kaaja, R; Viinikka, L; Ylikorkala, O, 1993)
"Aspirin has proved its efficacy in primary and secondary pre-eclampsia prevention, especially when it is given at 150mg per day bedtime before 15 weeks of gestation to high-risk women."	2.58	[Pre-eclampsia prevention in 2018 in general population and in lupic women: At the dawn of a personalized medicine?] ( de Moreuil, C; Fauchais, AL; Lacut, K; Le Moigne, E; Merviel, P; Pan-Petesch, B; Pasquier, E; Tremouilhac, C, 2018)
"Background Systemic lupus erythematosus is associated with an increased risk of cardiovascular disease."	2.55	Primary prevention of cardiovascular disease in patients with systemic lupus erythematosus: case series and literature review. ( Afeltra, A; Fasano, S; Margiotta, DP; Navarini, L; Pantano, I; Pierro, L; Riccardi, A; Valentini, G, 2017)
"Miscarriage, premature delivery, and preeclampsia, as well as heart problems in the baby are the major complications that can occur."	2.53	Pregnancy in women with systemic lupus erythematosus (SLE). ( Moroni, G; Ponticelli, C, 2016)
"The management of lupus nephritis in pregnancy presents a diagnostic and therapeutic challenge for providers."	2.52	Pregnancy and Lupus Nephritis. ( Garovic, VD; Kattah, AG, 2015)
"a previous history of miscarriage, foetal loss, placental insufficiency or thrombosis."	2.47	Lupus and pregnancy: integrating clues from the bench and bedside. ( Khamashta, MA; Ruiz-Irastorza, G, 2011)
"Women with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are subject to several complications during pregnancy, including reactivation of SLE, thrombosis, miscarriage, neonatal lupus, pregnancy-induced hypertension, pulmonary hypertension and drug toxicity."	2.43	[Systematic lupus erythematosus and antiphospholipid syndrome during pregnancy]. ( Khamashta, MA; Ruiz-Irastorza, G, 2006)
"Since 1987 the antiphospholipid syndrome has been recognized as a major cause of acquired thrombophilia, whether it is associated with systemic lupus erythematosus or occurs as a free-standing syndrome (primary form)."	2.41	[Antiphospholipid syndrome]. ( Arvieux, J; Hachulla, E, 2002)
"Insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE) are two common autoimmune disorders that affect women of childbearing age."	2.39	Nutritional consequences of chronic maternal conditions during pregnancy and lactation: lupus and diabetes. ( Ferris, AM; Reece, EA, 1994)
" Clinicians who decide to manage complicated or potentially complicated patients with chronic administration of aspirin must continue to study these mothers, fetuses, and neonates intensively and to document their results."	2.38	Low-dose aspirin to improve perinatal outcome. ( Barton, JR; Sibai, BM, 1991)
"Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention."	2.36	Acute effects of aspirin and acetaminophen on renal function. ( Kimberly, RP; Plotz, PH, 1981)
"Common complications of systemic lupus erythematosus include nephritis, hematologic complications such as thrombocytopenia, and a variety of neurologic abnormalities."	1.91	Society for Maternal-Fetal Medicine Consult Series #64: Systemic lupus erythematosus in pregnancy. ( Craigo, S; Kuller, JA; Norton, ME; Osmundson, SS; Porter, F; Silver, R, 2023)
" In age-adjusted analyses, aspirin plus LMWH regardless of dosage was associated with significantly higher odds of live birth compared with no antithrombotic use (OR = 7."	1.91	Management and outcomes of women with antiphospholipid syndrome during pregnancy. ( Adurty, S; D'Angelo, D; DeSancho, MT; Tao, JJ, 2023)
"Atherosclerosis develops early in systemic lupus erythematosus (SLE) patients and is an important cause of mortality."	1.40	Carotid subclinical atherosclerosis is associated with disease activity but not vitamin D in Korean systemic lupus erythematosus. ( Bae, CB; Jung, JY; Kim, HA; Koh, BR; Suh, CH, 2014)
"Previous thrombosis, diagnosis of systemic lupus erythematosus (SLE) and triple antiphospholipid (aPL) antibody positivity have recently been found to be independent factors associated to pregnancy failure during conventional therapy in women with antiphospholipid syndrome (APS)."	1.40	Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicentre retrospective study. ( Alijotas-Reig, J; Andreoli, L; Bertero, MT; Bremme, K; Brucato, A; Canti, V; Caramaschi, P; De Carolis, S; Del Ross, T; Di Poi, E; Galeazzi, M; Gerosa, M; Maina, A; Mekinian, A; Meroni, PL; Mosca, M; Ramoni, V; Ruffatti, A; Salvan, E; Tincani, A; Trespidi, L, 2014)
"Aspirin is an effective treatment option for these patients."	1.39	Aspirin resistance in systemic lupus erythematosus. A pilot study. ( Akdogan, A; Akman, U; Bilgen, SA; Buyukasik, Y; Dogan, I; Ertenli, I; Karadag, O; Kilic, L; Kiraz, S, 2013)
"Systemic lupus erythematosus is a chronic autoimmune disorder which affects women with child bearing potential."	1.38	[Successful completed pregnancies in patients with systemic lupus erythematosus]. ( Kiss, E; Szegedi, G; Tarr, T; Zeher, M, 2012)
"Systemic lupus erythematosus is a chronic inflammatory disorder that predisposes to acute coronary thrombosis."	1.37	Effective management of acute coronary thrombosis in a young woman with lupus using aggressive medical therapy. ( Matthai, WH; Patel, PJ; Untereker, WJ, 2011)
"These findings were compatible with systemic lupus erythematosus (SLE)."	1.36	[Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus]. ( Doi, H; Isobe, N; Kira, J; Ohyagi, Y; Tateishi, T; Yamasaki, R, 2010)
"This was a rare case of severe influenza-associated hemophagocytic syndrome and steroid-resistant pericardial effusion in an SLE patient."	1.36	Influenza virus B-associated hemophagocytic syndrome and recurrent pericarditis in a patient with systemic lupus erythematosus. ( Ando, H; Horai, Y; Minami, R; Miyamura, T; Nakamura, M; Sonomoto, K; Suematsu, E; Takahama, S; Yamamoto, M, 2010)
"Between 20% and 40% of patients with systemic lupus erythematosus (SLE) have positive blood tests for antiphospholipid antibodies (aPLs)."	1.35	How to manage patients with systemic lupus erythematosus who are also antiphospholipid antibody positive. ( Giles, I; Rahman, A, 2009)
"Autoimmune diseases are a group of illnesses in which autoantibodies are produced against various organs, presenting with a variety of clinical symptoms."	1.32	Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage. ( Chen, L; Miller, RK; Ornoy, A; Silver, RM, 2004)
"An 18-year-old Saudi male with systemic lupus erythematosus (SLE) presented with mild right hemiparesis, followed by recurrent ischemic stroke."	1.31	Systemic lupus erythematosus associated with moyamoya syndrome. ( Al Rayes, HM; El Ramahi, KM, 2000)
"Pregnancy was authorized if disease was inactive on 20 mg/day prednisone or less for at least 1 yr."	1.30	Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies. ( Blétry, O; Darbois, Y; Godeau, P; Lê Huong, D; Lefèbvre, G; Piette, JC; Seebacher, J; Vauthier-Brouzes, D; Wechsler, B, 1997)
"The rate of recurrence of thrombosis was highest (1."	1.29	The management of thrombosis in the antiphospholipid-antibody syndrome. ( Cuadrado, MJ; Hughes, GR; Hunt, BJ; Khamashta, MA; Mujic, F; Taub, NA, 1995)
"Five warfarin-treated patients had five significant bleeding events (0."	1.28	Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. ( Brewer, PM; Rosove, MH, 1992)
"Eight patients, 3 with systemic lupus erythematosus (SLE) or "SLE-like" disease, 1 with sarcoidosis, and 4 with no connective tissue disease had transient ischemic attacks (TIA) or cerebral infarctions associated with high levels of anticardiolipin antibodies (ACA)."	1.28	Cerebral ischemia associated with anticardiolipin antibodies. ( Ernerudh, J; Lindström, F; Olsson, JE; Vrethem, M, 1992)
"Two patients had systemic lupus erythematosus, and the other five fulfilled criteria for the primary antiphospholipid syndrome."	1.28	Fetal loss treatment in patients with antiphospholipid antibodies. ( Barquinero, J; Genover, E; Jordana, R; Ordi, J; Selva, A; Tolosa, C; Vilardell, M, 1989)
"After treatment the pregnancy wastage rate was 55% and 25% in the 2 groups respectively."	1.28	Pregnancy loss with phospholipid antibodies: improved outcome with aspirin containing treatment. ( Cameron, K; Gatenby, PA; Shearman, RP, 1989)
"The hyperkalemia was disproportionate to the degree of renal excretory impairment."	1.27	Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. ( Kiley, J; Zager, P, 1984)
"A clinical diagnosis of systemic lupus erythematosus (SLE) was made in four women."	1.27	Lupus anticoagulant in pregnancy. ( Butler, WS; Liggins, GC; Lubbe, WF; Palmer, SJ, 1984)
"In whole blood from 30 patients with systemic lupus erythematosus (SLE), 10 normal subjects, and 40 patients with active seropositive rheumatoid arthritis (RA), there were negative correlations between the hematocrit level and the ASA half-life in vitro: r = -0."	1.27	Patterns of in vitro aspirin hydrolysis rates in rheumatoid arthritis and systemic lupus erythematosus. ( Costello, PB; Green, FA, 1986)
"This report describes two cases of systemic lupus erythematosus (SLE) treated with immunosuppressive agents."	1.27	Acute granulocytic leukemia following systemic lupus erythematosus. ( Goldberg, J; Paolozzi, FP, 1985)
"A 14-year-old girl in whom Reye syndrome developed during aspirin therapy for an inflammatory disorder proven to be systemic lupus erythematosus is reported."	1.27	Reye syndrome associated with aspirin therapy for systemic lupus erythematosus. ( Bale, JF; Corbett, AJ; Flanders, DJ; Hansen, JR; McCray, PB, 1985)
"The charts of 238 patients with systemic lupus erythematosus (SLE) were reviewed."	1.26	The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature. ( Anuras, S; LaBrecque, DR; Runyon, BA, 1980)
"Aspirin was discontinued and ibuprofen, 600 mg four times daily, begun."	1.26	Aspirin hepatotoxicity. ( Hindin, BI; Kanada, SA; Kolling, WM, 1978)
"Approximately 8% of patients with systemic lupus erythematosus have drug induced disease."	1.26	[New aspects of drug induced lupus erythematosus (author's transl)]. ( Robinson, HM, 1978)
"In 13 of 23 patients with systemic lupus erythematosus increases in serum creatinine ranged from 27 to 163 per cent, and those in urea nitrogen from 42 to 270 per cent."	1.26	Aspirin-induced depression of renal function. ( Kimberly, RP; Plotz, PH, 1977)
"The existence of hepatic involvement in systemic lupus erythematosus (SLE) is still contested in the literature."	1.26	Hepatic involvement in systemic lupus erythematosus. A case report. ( Forman, MB; Gear, AJ; Levy, H; Ninin, DT, 1981)
"A patient with systemic lupus erythematosus presented with moderately severe restrictive and obstructive ventilatory defects."	1.26	Pulmonary function abnormalities in systemic lupus erythematosus responsive to glucocorticoid therapy. ( Al-Bazzaz, F; Venizelos, PC, 1981)
"Hallucinations were either unformed (for example, bright lights, straight lines) or highly formed (for example, faces), in which case they were invariably recognized by the patient as inappropriate."	1.25	Cerebral disorders of vision in systemic lupus erythematosus. ( Brandt, KD; Cohen, AS; Lessell, S, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	79 (39.70)	18.7374
1990's	24 (12.06)	18.2507
2000's	41 (20.60)	29.6817
2010's	45 (22.61)	24.3611
2020's	10 (5.03)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Vascular Damage in Systemic Lupus Erythematosus (SLE)[NCT00731302]	Phase 1	70 participants (Actual)	Interventional	2005-04-30	Completed
A Multicenter, Double-blind, Randomized and Parallel Controlled Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Miscarriage With Antiphospholipid Syndrome[NCT04624269]	Phase 4	384 participants (Anticipated)	Interventional	2020-12-01	Not yet recruiting
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)[NCT00198068]		700 participants (Anticipated)	Observational	2003-09-30	Recruiting
A Randomized Controlled Trial of Strategies for the Prevention of Accelerated Atherosclerosis in Systemic Lupus Erythematosus - A Pilot Study[NCT00054938]	Phase 2	150 participants	Interventional	2003-03-31	Completed
Certolizumab to Prevent Pregnancy Complications in High-Risk Patients With APS or SLE - (IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy)[NCT03152058]	Phase 2	55 participants (Anticipated)	Interventional	2017-05-17	Recruiting
Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin as Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE (APS-STROKE)[NCT05995600]	Phase 4	400 participants (Anticipated)	Interventional	2023-12-31	Not yet recruiting
Apixaban for the Secondary Prevention of Thromboembolism: a Prospective Randomized Outcome Pilot Study Among Patients With the AntiphosPholipid Syndrome[NCT02295475]	Phase 4	48 participants (Actual)	Interventional	2014-12-10	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Cardiovascular Outcomes in Systemic Lupus Erythematosus. Current cardiology reports, 2022, Volume: 24, Issue:2 Topics: Aspirin; Cardiovascular Diseases; Disease Progression; Humans; Inflammation; Lupus Erythematosus, Sy	2022
Biochemical and clinical predictors in pregnant women with antiphospholipid syndrome and systemic lupus erythematosus: comprehensive update. Archives of gynecology and obstetrics, 2021, Volume: 304, Issue:5 Topics: Adult; Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Infant, Ne	2021
Primary prevention of cardiovascular disease in patients with systemic lupus erythematosus: case series and literature review. Lupus, 2017, Volume: 26, Issue:14 Topics: Adult; Antibodies, Antiphospholipid; Aspirin; Cardiovascular Diseases; Female; Humans; Hydroxychloro	2017
[Ocular involvement in rheumatoid arthritis, connective tissue diseases and vasculitis]. Zeitschrift fur Rheumatologie, 2017, Volume: 76, Issue:8 Topics: Acute Disease; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Aspirin; Collagen Diseases; Cross-Sec	2017
[Pre-eclampsia prevention in 2018 in general population and in lupic women: At the dawn of a personalized medicine?] La Revue de medecine interne, 2018, Volume: 39, Issue:12 Topics: Aspirin; Female; Humans; Lupus Erythematosus, Systemic; Pre-Eclampsia; Precision Medicine; Pregnancy	2018
Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis. Autoimmunity reviews, 2014, Volume: 13, Issue:3 Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Hemorrhage; Humans; Lupus Erythema	2014
[Serious organ damage and intractable clinical conditions in rheumatic and connective tissue disease--progress in pathophysiology and treatment. Topics: II. Clinical conditions special attention needed to be paid to; 2. Antiphospholipid syndrome]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2013, Oct-10, Volume: 102, Issue:10 Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin	2013
The efficacy of hydroxychloroquine in altering pregnancy outcome in women with antiphospholipid antibodies. Evidence and clinical judgment. Thrombosis and haemostasis, 2016, Volume: 115, Issue:2 Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Cohort Studies; Female; Heparin; H	2016
Pregnancy and Lupus Nephritis. Seminars in nephrology, 2015, Volume: 35, Issue:5 Topics: Abortion, Spontaneous; Anticoagulants; Antihypertensive Agents; Antiphospholipid Syndrome; Aspirin;	2015
Pregnancy in women with systemic lupus erythematosus (SLE). European journal of internal medicine, 2016, Volume: 32 Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspi	2016
Antiphospholipid antibody syndrome. Hematology. American Society of Hematology. Education Program, 2009 Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Blood Transfus	2009
Lupus and pregnancy: integrating clues from the bench and bedside. European journal of clinical investigation, 2011, Volume: 41, Issue:6 Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Anticoagulants; Aspirin; Azathioprine; Counseli	2011
[Management of antiphospholipid syndrome]. La Revue de medecine interne, 2012, Volume: 33, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; As	2012
[Antiphospholipid-syndrome - when to treat?]. Deutsche medizinische Wochenschrift (1946), 2012, Volume: 137, Issue:36 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; As	2012
[Antiphospholipid syndrome]. Annales de cardiologie et d'angeiologie, 2002, Volume: 51, Issue:3 Topics: Adult; Aged; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Femal	2002
Prophylaxis of the antiphospholipid syndrome: a consensus report. Lupus, 2003, Volume: 12, Issue:7 Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Humans; Lupus Erythematosus, Systemic; P	2003
Review of severe vaso-occlusive retinopathy in systemic lupus erythematosus and the antiphospholipid syndrome: associations, visual outcomes, complications and treatment. Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:1 Topics: Adult; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Combined Mo	2004
Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature. Rheumatology international, 2005, Volume: 25, Issue:4 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Anticoagulants; Antiphospholipid Syndrome; An	2005
Cardiovascular disease in lupus patients: should all patients be treated with statins and aspirin? Best practice & research. Clinical rheumatology, 2005, Volume: 19, Issue:5 Topics: Animals; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Humans; Hydroxymethylglutaryl-	2005
[Systematic lupus erythematosus and antiphospholipid syndrome during pregnancy]. Zeitschrift fur Rheumatologie, 2006, Volume: 65, Issue:3 Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Disease Progression; Female; Humans; Immunosuppr	2006
[Newborn from mother with antiphospholipid syndrome]. Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 115, Issue:5 Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; beta 2-Glycoprotein I; Female; Fet	2006
[Fetus monitoring of a mother suffering from the antiphospholipid syndrome]. Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 115, Issue:5 Topics: Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Biomarkers; Female	2006
Pseudo-allergic reactions to drugs and chemicals. Annals of allergy, 1983, Volume: 51, Issue:2 Pt 2 Topics: Anaphylaxis; Aspirin; Complement Activation; Complement System Proteins; Cyclooxygenase Inhibitors;	1983
The treatment of SLE: the case of conservative management. Clinics in rheumatic diseases, 1982, Volume: 8, Issue:1 Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antimalarials; Arthriti	1982
Systemic lupus erythematosus. Clinical obstetrics and gynecology, 1983, Volume: 26, Issue:3 Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Adrenal Cortex Hormones; Aspirin; Azathioprine;	1983
Acute effects of aspirin and acetaminophen on renal function. Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No Topics: Acetaminophen; Aspirin; Humans; Indomethacin; Kidney; Kidney Failure, Chronic; Liver Cirrhosis; Lupu	1981
Immunosuppression of experimental systemic lupus erythematosus and antiphospholipid syndrome. Transplantation proceedings, 1994, Volume: 26, Issue:6 Topics: Adjuvants, Immunologic; Androgens; Animals; Antibodies, Anti-Idiotypic; Antiphospholipid Syndrome; A	1994
Nutritional consequences of chronic maternal conditions during pregnancy and lactation: lupus and diabetes. The American journal of clinical nutrition, 1994, Volume: 59, Issue:2 Suppl Topics: Adult; Aspirin; Autoimmune Diseases; Diabetes Mellitus, Type 1; Female; Humans; Lactation Disorders;	1994
[Effect of pregnancy, menopause and hormone substitution therapy on disseminated systemic lupus erythematosus]. Presse medicale (Paris, France : 1983), 2000, Jan-15, Volume: 29, Issue:1 Topics: Aspirin; Estrogen Replacement Therapy; Female; Heparin; Humans; Lupus Erythematosus, Systemic; Ovula	2000
Pediatric autoimmune cardiovascular disease. The Journal of the Kentucky Medical Association, 2000, Volume: 98, Issue:7 Topics: Adolescent; Antibodies, Antinuclear; Aspirin; Autoimmune Diseases; Child; Child, Preschool; Coronary	2000
Management of thrombosis in antiphospholipid antibody syndrome. Rheumatic diseases clinics of North America, 2001, Volume: 27, Issue:3 Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Hemorrhage; Heparin; Humans; Lupus Erythematosus	2001
Histiocytic necrotizing lymphadenitis preceding systemic lupus erythematosus. Journal of the European Academy of Dermatology and Venereology : JEADV, 2001, Volume: 15, Issue:5 Topics: Adrenal Cortex Hormones; Adult; Aspirin; Biopsy, Needle; Cyclophosphamide; Diagnosis, Differential;	2001
Arthritis in the elderly. An overview. The Medical clinics of North America, 1976, Volume: 60, Issue:6 Topics: Adolescent; Adult; Aged; Aging; Anti-Inflammatory Agents; Arthritis; Arthritis, Infectious; Arthriti	1976
Systemic lupus erythematosus and pregnancy. Obstetrics and gynecology annual, 1978, Volume: 7 Topics: Antimalarials; Aspirin; Autoantibodies; B-Lymphocytes; Complement System Proteins; Female; Glucocort	1978
Hemostatic failure in clinical medicine. Seminars in hematology, 1977, Volume: 14, Issue:3 Topics: Acute Disease; Amyloidosis; Anticoagulants; Aspirin; Blood Platelet Disorders; Blood Vessels; Chroni	1977
Drug-induced lung disease. Monographs in pathology, 1978, Volume: 19 Topics: Alveolitis, Extrinsic Allergic; Antineoplastic Agents; Aspirin; Bronchial Spasm; Eosinophilia; Human	1978
Aspirin, liver, and rheumatic diseases. Journal of the Medical Association of the State of Alabama, 1976, Volume: 46, Issue:3 Topics: Adolescent; Adult; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Chemical and Drug Induced Li	1976
Rheumatoid arthritis: an overview. Texas medicine, 1976, Volume: 72, Issue:11 Topics: Adult; Arthritis; Arthritis, Reactive; Arthritis, Rheumatoid; Aspirin; Diagnosis, Differential; Fema	1976
[Role of antiphospholipid antibodies in fetal loss]. Presse medicale (Paris, France : 1983), 1992, Nov-14, Volume: 21, Issue:38 Topics: Abortion, Spontaneous; Adrenal Cortex Hormones; Antibodies, Anticardiolipin; Antibodies, Antiphospho	1992
Low-dose aspirin to improve perinatal outcome. Clinical obstetrics and gynecology, 1991, Volume: 34, Issue:2 Topics: Antibodies; Aspirin; Blood Coagulation Factors; Cardiolipins; Female; Fetal Growth Retardation; Fetu	1991
Lupus anticoagulant and pregnancy. American journal of obstetrics and gynecology, 1985, Oct-01, Volume: 153, Issue:3 Topics: Aspirin; Autoantibodies; Blood Coagulation Factors; Female; Fetal Death; Fetal Diseases; Fetal Growt	1985
The spectrum of drug-induced pulmonary disease. Annals of internal medicine, 1972, Volume: 77, Issue:6 Topics: Adrenal Cortex Hormones; Aerosols; Analgesics; Aspirin; Autonomic Agents; Bleomycin; Busulfan; Contr	1972
A critical reappraisal of juvenile rheumatoid arthritis. Clinical orthopaedics and related research, 1971, Volume: 74 Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine	1971
An approach to the use of immunosuppressive drugs in nonmalignant diseases. The Journal of allergy and clinical immunology, 1973, Volume: 52, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G	1973
Juvenile rheumatoid arthritis. Pediatric clinics of North America, 1974, Volume: 21, Issue:4 Topics: Antibodies, Antinuclear; Antimalarials; Arthritis, Juvenile; Aspirin; Blood Sedimentation; Child; Co	1974
[Blood platelet diseases]. Medizinische Klinik, 1973, Jan-12, Volume: 68, Issue:2 Topics: Adenosine Diphosphate; Afibrinogenemia; Aspirin; Blood Platelet Disorders; Blood Platelets; Diagnosi	1973
Rheumatoid arthritis. A potentially crippling disease that may attack at any age. Clinical symposia (Summit, N.J. : 1957), 1971, Volume: 23, Issue:1 Topics: Adrenal Cortex Hormones; Agammaglobulinemia; Age Factors; Analgesics; Antimalarials; Arthritis, Juve	1971

Article	Year
Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. Arthritis care & research, 2014, Volume: 66, Issue:2 Topics: Adult; Aspirin; Biomarkers; Blood Platelets; C-Reactive Protein; Chi-Square Distribution; Cyclooxyge	2014
Low-dose aspirin vs low-dose aspirin plus low-intensity warfarin in thromboprophylaxis: a prospective, multicentre, randomized, open, controlled trial in patients positive for antiphospholipid antibodies (ALIWAPAS). Rheumatology (Oxford, England), 2014, Volume: 53, Issue:2 Topics: Adult; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune	2014
Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosus. Arthritis and rheumatism, 2005, Oct-15, Volume: 53, Issue:5 Topics: Anticholesteremic Agents; Antihypertensive Agents; Arteriosclerosis; Aspirin; Drug Therapy, Combinat	2005
Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus. Lupus, 2007, Volume: 16, Issue:12 Topics: Adult; Aspirin; Cyclooxygenase Inhibitors; Drug Resistance; Epoprostenol; Female; Humans; Lupus Eryt	2007
Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:5 Topics: Abortion, Habitual; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antibodies	2008
Comparative effects of aspirin and ibuprofen in the management of systemic lupus erythematosus. Arthritis and rheumatism, 1980, Volume: 23, Issue:12 Topics: Aspirin; Clinical Trials as Topic; Humans; Ibuprofen; Lupus Erythematosus, Systemic; Placebos; Resea	1980
Thrombosis and antiphospholipid syndrome: a preliminary assessment of three antithrombotic treatments. Lupus, 1994, Volume: 3, Issue:2 Topics: Adolescent; Adult; Antibodies, Anticardiolipin; Anticoagulants; Antiphospholipid Syndrome; Aspirin;	1994
Production of prostacyclin and thromboxane in lupus pregnancies: effect of small dose of aspirin. Obstetrics and gynecology, 1993, Volume: 81, Issue:3 Topics: Adult; Antibodies, Antiphospholipid; Aspirin; Chromatography, High Pressure Liquid; Epoprostenol; Fe	1993
Determinants of enhanced thromboxane biosynthesis in patients with systemic lupus erythematosus. Arthritis and rheumatism, 1999, Volume: 42, Issue:12 Topics: Adult; Antibodies, Antiphospholipid; Antigens; Aspirin; Cross-Sectional Studies; Dose-Response Relat	1999
Low molecular weight heparin and warfarin in the treatment of patients with antiphospholipid syndrome during pregnancy. Thrombosis and haemostasis, 2001, Volume: 86, Issue:6 Topics: Abnormalities, Drug-Induced; Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune D	2001
Psychopathology in systemic lupus erythematosus. I. Psychiatric observations. Seminars in arthritis and rheumatism, 1973, Volume: 3, Issue:2 Topics: Adolescent; Adult; Affective Symptoms; Aspirin; Azathioprine; Brain Diseases; Clinical Trials as Top	1973

Article	Year
Clinical and therapeutic value of the adjusted Global Antiphospholipid Syndrome Score in primary obstetric antiphospholipid syndrome. Lupus, 2022, Volume: 31, Issue:3 Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Humans; Lupus Erythematosus, Systemic; P	2022
Impact of low-dose acetylsalicylic acid on pregnancy outcome in systemic lupus erythematosus: results from a multicentre study. Lupus science & medicine, 2022, Volume: 9, Issue:1 Topics: Aspirin; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Pre-Eclampsia; Pregnancy; P	2022
Society for Maternal-Fetal Medicine Consult Series #64: Systemic lupus erythematosus in pregnancy. American journal of obstetrics and gynecology, 2023, Volume: 228, Issue:3 Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecular-Wei	2023
Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus. Drugs in R&D, 2023, Volume: 23, Issue:1 Topics: Antirheumatic Agents; Aspirin; Cytokines; Female; Humans; Hydroxychloroquine; Infant, Newborn; Lupus	2023
Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus. Drugs in R&D, 2023, Volume: 23, Issue:1 Topics: Antirheumatic Agents; Aspirin; Cytokines; Female; Humans; Hydroxychloroquine; Infant, Newborn; Lupus	2023
Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus. Drugs in R&D, 2023, Volume: 23, Issue:1 Topics: Antirheumatic Agents; Aspirin; Cytokines; Female; Humans; Hydroxychloroquine; Infant, Newborn; Lupus	2023
Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus. Drugs in R&D, 2023, Volume: 23, Issue:1 Topics: Antirheumatic Agents; Aspirin; Cytokines; Female; Humans; Hydroxychloroquine; Infant, Newborn; Lupus	2023
Management and outcomes of women with antiphospholipid syndrome during pregnancy. Journal of thrombosis and thrombolysis, 2023, Volume: 55, Issue:4 Topics: Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Infant, Newborn;	2023
Association of preterm outcome with maternal systemic lupus erythematosus: a retrospective cohort study. Italian journal of pediatrics, 2023, Apr-01, Volume: 49, Issue:1 Topics: Aspirin; Birth Weight; Child; China; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Lup	2023
Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study. Lupus, 2019, Volume: 28, Issue:14 Topics: Adult; Aspirin; Female; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Lupu	2019
Caught in a Flare. The New England journal of medicine, 2020, Aug-13, Volume: 383, Issue:7 Topics: Arthralgia; Aspirin; Atorvastatin; Brain; Diagnosis, Differential; Exanthema; Fatigue; Female; Hemat	2020
Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients. Annals of the rheumatic diseases, 2021, Volume: 80, Issue:9 Topics: Angiotensin-Converting Enzyme Inhibitors; Antirheumatic Agents; Aspirin; Drug Tapering; Europe; Fema	2021
Systemic lupus erythematosus with Degos disease: role of dermatoscopy in diagnosis. International journal of dermatology, 2017, Volume: 56, Issue:7 Topics: Adolescent; Aspirin; Biopsy, Needle; Dermoscopy; Drug Therapy, Combination; Female; Humans; Hydroxyc	2017
Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus. The Journal of rheumatology, 2017, Volume: 44, Issue:7 Topics: Adult; Antirheumatic Agents; Aspirin; Cardiovascular Diseases; Drug Synergism; Drug Therapy, Combina	2017
Serological evolution in women with positive antiphospholipid antibodies. Seminars in arthritis and rheumatism, 2017, Volume: 47, Issue:3 Topics: Adult; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Biomarkers;	2017
Isolated tricuspid valve Libman-Sacks endocarditis in a patient with antiphospholipid antibody syndrome. BMJ case reports, 2017, Aug-22, Volume: 2017 Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Echocardiography; Endocarditis; Female; H	2017
Gangrene of All Digits and Toes Attributable to Systemic Lupus Erythematosus With Negative Antiphospholipid Antibodies. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2019, Volume: 25, Issue:6 Topics: Adult; Amputation, Surgical; Antibodies, Antiphospholipid; Aspirin; Female; Fingers; Follow-Up Studi	2019
[Pregnancy outcome in a woman with premature ovarian insufficiency complicated by systemic lupus erythematosus during pregnancy: a case report]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2017, Dec-20, Volume: 37, Issue:12 Topics: Aspirin; Cesarean Section; Embryo Transfer; Female; Fertilization in Vitro; Humans; Lupus Erythemato	2017
Therapeutic adherence in patients with systemic lupus erythematosus: a cross-sectional study. Romanian journal of internal medicine = Revue roumaine de medecine interne, 2018, Jun-01, Volume: 56, Issue:2 Topics: Adolescent; Adult; Age of Onset; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Secti	2018
Risk factors for development of early infectious and noninfectious complications in systemic lupus erythematosus patients undergoing major surgery. Lupus, 2018, Volume: 27, Issue:12 Topics: Adolescent; Adult; Aged; Anemia; Aspirin; Child; Elective Surgical Procedures; Female; Humans; Logis	2018
Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort. Annals of the rheumatic diseases, 2019, Volume: 78, Issue:7 Topics: Adolescent; Adult; Aspirin; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Platelet Agg	2019
Critical reversible bilateral internal carotid artery stenosis associated with SLE. Rheumatology (Oxford, England), 2013, Volume: 52, Issue:7 Topics: Adult; Antirheumatic Agents; Aspirin; Carotid Stenosis; Drug Therapy, Combination; Female; Glucocort	2013
Aspirin resistance in systemic lupus erythematosus. A pilot study. Lupus, 2013, Volume: 22, Issue:8 Topics: Adult; Antibodies, Anticardiolipin; Aspirin; Case-Control Studies; Drug Resistance; Electric Impedan	2013
Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicentre retrospective study. Thrombosis and haemostasis, 2014, Volume: 112, Issue:4 Topics: Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Europe; Female; Heparin; Hu	2014
Carotid subclinical atherosclerosis is associated with disease activity but not vitamin D in Korean systemic lupus erythematosus. Lupus, 2014, Volume: 23, Issue:14 Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; B	2014
Movement disorders in systemic lupus erythematosus and antiphospholipid syndrome--a video presentation. BMJ case reports, 2015, May-07, Volume: 2015 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiphospholipid Syndrome; Aspirin; Humans; Imm	2015
Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study. American journal of obstetrics and gynecology, 2016, Volume: 214, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Anticoagulants; Antige	2016
Low-dose aspirin as primary prophylaxis for cardiovascular events in systemic lupus erythematosus: a long-term retrospective cohort study. Rheumatology (Oxford, England), 2016, Volume: 55, Issue:9 Topics: Adult; Aspirin; Cardiovascular Diseases; Cause of Death; Female; Humans; Incidence; Italy; Kaplan-Me	2016
Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study. Hypertension in pregnancy, 2017, Volume: 36, Issue:1 Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Databases, Factual; Female; Heparin, Low-	2017
Hydroxychloroquine-induced hyperpigmentation: the staining pattern. Journal of cutaneous pathology, 2008, Volume: 35, Issue:12 Topics: Aged; Antacids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents	2008
Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies. Arthritis and rheumatism, 2009, Jan-15, Volume: 61, Issue:1 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antirheuma	2009
Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. Therapeutic drug monitoring, 2009, Volume: 31, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Progression; Female; Hearing Loss;	2009
Case records of the Massachusetts General Hospital. Case 5-2009. A 47-year-old woman with a rash and numbness and pain in the legs. The New England journal of medicine, 2009, Feb-12, Volume: 360, Issue:7 Topics: Antibodies, Antinuclear; Antirheumatic Agents; Aspirin; Biopsy; Diagnosis, Differential; Dry Eye Syn	2009
Accelerated atherosclerosis in systemic lupus erythematosus: perspectives towards decreasing cardiovascular morbidity and mortality. Lupus, 2009, Volume: 18, Issue:5 Topics: Aspirin; Azetidines; Clinical Trials as Topic; Coronary Artery Disease; Drug Therapy, Combination; E	2009
How to manage patients with systemic lupus erythematosus who are also antiphospholipid antibody positive. Best practice & research. Clinical rheumatology, 2009, Volume: 23, Issue:4 Topics: Algorithms; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female	2009
Influenza virus B-associated hemophagocytic syndrome and recurrent pericarditis in a patient with systemic lupus erythematosus. Modern rheumatology, 2010, Volume: 20, Issue:2 Topics: Anti-Inflammatory Agents; Aspirin; Colchicine; Drug Therapy, Combination; Humans; Influenza B virus;	2010
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. Pediatric nephrology (Berlin, Germany), 2010, Volume: 25, Issue:7 Topics: Administration, Oral; Antiphospholipid Syndrome; Aspirin; Calcinosis; Child; Cyclosporine; Dermatolo	2010
OCT follow-up of systemic lupus erythematosus choroidopathy. Ocular immunology and inflammation, 2010, Volume: 18, Issue:2 Topics: 4-Hydroxycoumarins; Adolescent; Adrenal Cortex Hormones; Angiography; Antibodies, Antinuclear; Aspir	2010
[Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus]. Rinsho shinkeigaku = Clinical neurology, 2010, Volume: 50, Issue:5 Topics: 1-Naphthylamine; Adult; Aspirin; Calcium Channel Blockers; Diagnosis, Differential; Female; Hemipleg	2010
[Narcolepsy associated with systemic lupus erythematosus]. La Revue de medecine interne, 2011, Volume: 32, Issue:11 Topics: Adult; Aspirin; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Lup	2011
Systemic lupus erythematosus in a 3-month old male presenting as thrombocytopenia. Lupus, 2011, Volume: 20, Issue:5 Topics: Aspirin; Fibrinolytic Agents; Glucocorticoids; Humans; Immunosuppressive Agents; Infant; Lupus Eryth	2011
Livedo racemosa, secondary to drug-induced systemic lupus erythematosus. Dermatology online journal, 2010, Nov-15, Volume: 16, Issue:11 Topics: Adult; Aspirin; Autoantibodies; Histones; Humans; Livedo Reticularis; Lupus Erythematosus, Systemic;	2010
Chorea as an unusual presenting feature of anti-phospholipid syndrome. JPMA. The Journal of the Pakistan Medical Association, 2010, Volume: 60, Issue:11 Topics: Antiphospholipid Syndrome; Aspirin; Chorea; Diagnosis, Differential; Humans; Lupus Erythematosus, Sy	2010
Effective management of acute coronary thrombosis in a young woman with lupus using aggressive medical therapy. Cardiology, 2011, Volume: 118, Issue:1 Topics: Adult; Aspirin; Clopidogrel; Coronary Thrombosis; Eptifibatide; Female; Fibrinolytic Agents; Heparin	2011
Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre, case-control study. Rheumatology (Oxford, England), 2011, Volume: 50, Issue:9 Topics: Abortion, Spontaneous; Adult; Antiphospholipid Syndrome; Aspirin; Autoimmune Diseases; Biomarkers; C	2011
Aspirin resistance may be associated with adverse pregnancy outcomes. Neuro endocrinology letters, 2011, Volume: 32, Issue:3 Topics: Adult; Aspirin; Cesarean Section; Drug Resistance; Female; Fetal Distress; Humans; Infant, Newborn;	2011
[Successful completed pregnancies in patients with systemic lupus erythematosus]. Orvosi hetilap, 2012, Mar-25, Volume: 153, Issue:12 Topics: Adrenal Cortex Hormones; Adult; Aspirin; Azathioprine; Birth Weight; Female; Follow-Up Studies; Gest	2012
A fulminant neurologic presentation of systemic lupus erythematosus. International journal of rheumatic diseases, 2012, Volume: 15, Issue:2 Topics: Anticoagulants; Antihypertensive Agents; Aspirin; Brain; Cyclophosphamide; Diagnosis, Differential;	2012
Extensive skin necrosis induced by low-molecular-weight heparin in a patient with systemic lupus erythematosus and antiphospholipid syndrome. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2012, Volume: 18, Issue:4 Topics: Antiphospholipid Syndrome; Aspirin; Drug Eruptions; Drug Therapy, Combination; Enoxaparin; Female; F	2012
[Mondor's thrombophlebitis and antiphospholipid antibodies]. Presse medicale (Paris, France : 1983), 2003, Jan-18, Volume: 32, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antiphospholipid Syndr	2003
Anti-inflammatory agents in the treatment of connective tissue diseases. Virginia medical monthly, 1963, Volume: 90 Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Aspirin; Chloroquine; Humans; Lupus Eryth	1963
[Therapeutic results of aspirin corticosteroid combinations in rheumatic disease patients]. Hospital (Rio de Janeiro, Brazil), 1962, Volume: 62 Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Aspirin; Fibromyalgia; Humans; Lupus Eryt	1962
SYSTEMIC LUPUS ERYTHEMATOSUS WITH ERYTHERMALGIA. Archives of internal medicine, 1963, Volume: 112 Topics: Aspirin; Erythromelalgia; Humans; Lupus Erythematosus, Systemic; Temperature	1963
DIAGNOSIS: DISCOID LUPUS ERYTHEMATOSUS? Archives of dermatology, 1964, Volume: 90 Topics: Adrenal Cortex Hormones; Aspirin; Face; Hand; Hepatitis; Humans; Joint Diseases; Knee; Lupus Erythem	1964
CUTANEOUS MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS. Archives of dermatology, 1964, Volume: 90 Topics: Adrenal Cortex Hormones; Alopecia; Anti-Bacterial Agents; Antimalarials; Aspirin; Blister; Drug Erup	1964
[OUR PRESENT EXPERIENCE IN DIAGNOSIS AND TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, Nov-26, Volume: 40 Topics: Adolescent; Adrenocorticotropic Hormone; Aspirin; Chloroquine; Cortisone; Diagnosis; Drug Therapy; H	1964
ISOLATION AND CHARACTERIZATION OF MYCOPLASMAS (PPLO) FROM PATIENTS WITH RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS AND REITER'S SYNDROME. Arthritis and rheumatism, 1965, Volume: 8 Topics: Adolescent; Arthritis; Arthritis, Juvenile; Arthritis, Reactive; Arthritis, Rheumatoid; Aspirin; Com	1965
[Which abortion prevention should be chosen in the case of antiphospholipid syndrome?]. Deutsche medizinische Wochenschrift (1946), 2004, Jun-04, Volume: 129, Issue:23 Topics: Abortion, Spontaneous; Adrenal Cortex Hormones; Adult; Anticoagulants; Antiphospholipid Syndrome; As	2004
Maternal autoimmune diseases and immunologically induced embryonic and fetoplacental damage. Birth defects research. Part A, Clinical and molecular teratology, 2004, Volume: 70, Issue:6 Topics: Abortion, Habitual; Animals; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome	2004
Therapeutic management of antiphospholipid syndrome in aspirin sensitive patients. Lupus, 2004, Volume: 13, Issue:7 Topics: Antiphospholipid Syndrome; Aspirin; Humans; Lupus Erythematosus, Systemic; Platelet Aggregation Inhi	2004
Predictors of cognitive dysfunction in patients with systemic lupus erythematosus. Neurology, 2005, Jan-25, Volume: 64, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Aspirin; Autoant	2005
Splenic infarction in a pregnant woman with systemic lupus erythematosus. Clinical rheumatology, 2005, Volume: 24, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Antibodies, Anticardiolipin; Aspirin; Cesarean Section; Drug Therap	2005
Moderate dose oral anticoagulant therapy in patients with the antiphospholipid syndrome? No. Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:5 Topics: Administration, Oral; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Clinical Trials as Topic;	2005
Minor physical anomalies are not increased in the offspring of mothers with systemic lupus erythematosus. Annals of the rheumatic diseases, 2006, Volume: 65, Issue:2 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Congenital Abnormalities; Fe	2006
Late in-stent thrombosis in a patient with systemic lupus erythematosus and hyperhomocysteinemia while on clopidogrel and aspirin. The Journal of invasive cardiology, 2006, Volume: 18, Issue:6 Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Coagulation Disorders; Clopidogrel; Coronary Artery D	2006
Clinical thrombotic manifestations in SLE patients with and without antiphospholipid antibodies: a 5-year follow-up. Clinical reviews in allergy & immunology, 2007, Volume: 32, Issue:2 Topics: Adult; Antibodies, Antiphospholipid; Antibody Specificity; Anticoagulants; Antiphospholipid Syndrome	2007
Influence of aspirin on the clinical outcomes of 103 anti-phospholipid antibodies-positive patients. Lupus, 2008, Volume: 17, Issue:1 Topics: Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Aspirin; Disease Progression; Female;	2008
Successful full-term pregnancies with assisted reproduction supported with prednisolone, acetylsalicylic acid and high progesterone doses in a lupus patient. Clinical and experimental obstetrics & gynecology, 2007, Volume: 34, Issue:4 Topics: Administration, Intravaginal; Administration, Oral; Adult; Anti-Inflammatory Agents; Aspirin; Female	2007
Fever associated with juvenile rheumatoid arthritis. The New England journal of medicine, 1967, Jan-05, Volume: 276, Issue:1 Topics: Adolescent; Adult; Arthritis, Juvenile; Aspirin; Child; Diagnosis, Differential; Female; Fever; Huma	1967
Medical management of patients with disability due to arthritis. Archives of physical medicine and rehabilitation, 1967, Volume: 48, Issue:3 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Bacterial Agents; Antimalarials; Arthritis, I	1967
Fetal survival after prednisone suppression of maternal lupus-anticoagulant. Lancet (London, England), 1983, Jun-18, Volume: 1, Issue:8338 Topics: Adult; Antibodies, Antinuclear; Aspirin; Blood Coagulation Disorders; Blood Coagulation Factors; Fem	1983
Hyporeninemic hypoaldosteronism in two patients with systemic lupus erythematosus. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1984, Volume: 4, Issue:1 Topics: 18-Hydroxycorticosterone; Adolescent; Aldosterone; Aspirin; Female; Fludrocortisone; Humans; Hyperka	1984
Lupus anticoagulant in pregnancy. British journal of obstetrics and gynaecology, 1984, Volume: 91, Issue:4 Topics: Aspirin; Blood Coagulation Disorders; Blood Coagulation Factors; Chorea; Drug Therapy, Combination;	1984
Use of ibuprofen in unusual circumstances. The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A Topics: Arthritis, Rheumatoid; Aspirin; Bartter Syndrome; Cyclooxygenase Inhibitors; Digoxin; Drug Hypersens	1984
[Use of the preparation essentiale in the therapy of lupus erythematosus]. Vestnik dermatologii i venerologii, 1983, Issue:5 Topics: Adolescent; Adult; Aged; Aspirin; Chloroquine; Chronic Disease; Drug Combinations; Drug Evaluation;	1983
Effect of acetylsalicylic acid on renal function in systemic lupus erythematosus. European journal of clinical pharmacology, 1982, Volume: 23, Issue:6 Topics: Adult; Aged; Aspirin; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Functio	1982
Inhibitors of immune complex induced human platelet aggregation and release in plasma. Thrombosis research, 1982, Dec-01, Volume: 28, Issue:5 Topics: Antibodies; Antigen-Antibody Complex; Aspirin; Blood Platelets; Depression, Chemical; Dipyridamole;	1982
Management plan of systemic lupus erythematosus -- a flow chart. Singapore medical journal, 1980, Volume: 21, Issue:4 Topics: Aspirin; Cyclophosphamide; Humans; Hydrocortisone; Lupus Erythematosus, Systemic; Prednisolone	1980
Hepatic involvement in systemic lupus erythematosus. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, May-09, Volume: 59, Issue:20 Topics: Adult; Alkaline Phosphatase; Aspirin; Chemical and Drug Induced Liver Injury; Female; Humans; Liver;	1981
Pulmonary function abnormalities in systemic lupus erythematosus responsive to glucocorticoid therapy. Chest, 1981, Volume: 79, Issue:6 Topics: Adult; Aspirin; Dyspnea; Glucocorticoids; Humans; Lung; Lupus Erythematosus, Systemic; Male; Pleural	1981
Treatment decisions in systemic lupus erythematosus. Arthritis and rheumatism, 1980, Volume: 23, Issue:3 Topics: Arthritis; Aspirin; Central Nervous System Diseases; Decision Making; Humans; Immunosuppressive Agen	1980
The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature. The American journal of medicine, 1980, Volume: 69, Issue:2 Topics: Adolescent; Adult; Aged; Aspirin; Biopsy; Chemical and Drug Induced Liver Injury; Child, Preschool;	1980
Effects of aspirin and acetaminophen on the liver. Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No Topics: Acetaminophen; Adolescent; Adult; Alcoholism; Arthritis, Juvenile; Aspirin; Child; Female; Humans; L	1981
A prospective study on pregnancy risk of antiphospholipid antibodies in association with systemic lupus erythematosus. Journal of reproductive immunology, 1995, Volume: 28, Issue:2 Topics: Antibodies, Antiphospholipid; Aspirin; Female; Humans; Lupus Coagulation Inhibitor; Lupus Erythemato	1995
The management of thrombosis in the antiphospholipid-antibody syndrome. The New England journal of medicine, 1995, Apr-13, Volume: 332, Issue:15 Topics: Adolescent; Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Follow-Up Studies; Hu	1995
The management of thrombosis in the antiphospholipid-antibody syndrome. The New England journal of medicine, 1995, Apr-13, Volume: 332, Issue:15 Topics: Adolescent; Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Follow-Up Studies; Hu	1995
The management of thrombosis in the antiphospholipid-antibody syndrome. The New England journal of medicine, 1995, Apr-13, Volume: 332, Issue:15 Topics: Adolescent; Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Follow-Up Studies; Hu	1995
The management of thrombosis in the antiphospholipid-antibody syndrome. The New England journal of medicine, 1995, Apr-13, Volume: 332, Issue:15 Topics: Adolescent; Adult; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Follow-Up Studies; Hu	1995
The significance of experimental models of systemic lupus erythematosus and antiphospholipid syndrome induced by idiotypic manipulation. Israel journal of medical sciences, 1994, Volume: 30, Issue:1 Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Anticardiolipin; Antibodies, Antinuclear; Antiphosp	1994
Combined corticosteroid and aspirin treatment for the high risk lupus pregnancy. British journal of obstetrics and gynaecology, 1993, Volume: 100, Issue:6 Topics: Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Female; Fetal Death; Gestational Age;	1993
Intravenous immunoglobulin treatment of pregnant patients with recurrent pregnancy losses associated with antiphospholipid antibodies. Acta obstetricia et gynecologica Scandinavica, 1993, Volume: 72, Issue:1 Topics: Abortion, Spontaneous; Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Drug	1993
Anticardiolipin syndrome, aspirin therapy and fetal malformation. Lupus, 1993, Volume: 2, Issue:1 Topics: Abnormalities, Drug-Induced; Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Aspirin;	1993
Aspirin-interleukin-3 interrelationships in patients with anti-phospholipid syndrome. American journal of reproductive immunology (New York, N.Y. : 1989), 1996, Volume: 35, Issue:2 Topics: Antiphospholipid Syndrome; Aspirin; Cells, Cultured; Female; Humans; Interleukin-3; Leukocytes, Mono	1996
Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies. British journal of rheumatology, 1997, Volume: 36, Issue:7 Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A	1997
Prophylactic antithrombotic therapy for patients with systemic lupus erythematosus with or without antiphospholipid antibodies: do the benefits outweigh the risks? A decision analysis. Archives of internal medicine, 2000, Jul-10, Volume: 160, Issue:13 Topics: Administration, Oral; Adult; Antibodies, Anticardiolipin; Antibodies, Antiphospholipid; Anticoagulan	2000
Should low-dose aspirin also be a background therapy for all patients with systemic lupus erythematosus (SLE)? Lupus, 2000, Volume: 9, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Coronary Disease; Humans; Hypertension; Lupus Eryt	2000
Systemic lupus erythematosus associated with moyamoya syndrome. Lupus, 2000, Volume: 9, Issue:8 Topics: Adolescent; Anticoagulants; Aspirin; Brain; Brain Ischemia; Carotid Artery, Internal; Carotid Stenos	2000
Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. British journal of haematology, 2001, Volume: 115, Issue:2 Topics: Adult; Aged; Annexin A5; Antiphospholipid Syndrome; Arthritis, Rheumatoid; Aspirin; Blood Platelets;	2001
Multiple sterile abscesses in antiphospholipid antibody syndrome. Cutis, 2001, Volume: 68, Issue:4 Topics: Abscess; Adult; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Extremities; Female;	2001
[Course of pregnancy in a patient with systemic lupus erythematosus--case report]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2002, Volume: 55, Issue:1-2 Topics: Adult; Aspirin; Drug Therapy, Combination; Female; Humans; Lupus Erythematosus, Systemic; Prednisone	2002
Aspirin and renal function. Lancet (London, England), 1977, Apr-30, Volume: 1, Issue:8018 Topics: Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Papillary Necrosis; Lupus Erythematosus, Syst	1977
Renal prostaglandins in systemic lupus erythematosus. Lancet (London, England), 1978, Sep-09, Volume: 2, Issue:8089 Topics: Aspirin; Cyclooxygenase Inhibitors; Glomerular Filtration Rate; Humans; Kidney; Lupus Erythematosus,	1978
Serologically active clinically quiescent systemic lupus erythematosus: a discordance between clinical and serologic features. The American journal of medicine, 1979, Volume: 66, Issue:2 Topics: Adult; Antibodies, Antinuclear; Aspirin; Chloroquine; Complement C3; DNA; DNA Helicases; Female; Glo	1979
Aspirin hepatotoxicity. American journal of hospital pharmacy, 1978, Volume: 35, Issue:3 Topics: Adolescent; Adult; Aging; Aspirin; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Li	1978
Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis. The Journal of allergy and clinical immunology, 1977, Volume: 60, Issue:5 Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents; Aspirin; Asthma; Cyclooxygenase Inhib	1977
A circulating anticoagulant directed against factor XIa in systemic lupus erythematosus. Arthritis and rheumatism, 1979, Volume: 22, Issue:10 Topics: Adult; Aspirin; Blood Coagulation Disorders; Blood Coagulation Tests; Factor XI; Female; Hemorrhage;	1979
[New aspects of drug induced lupus erythematosus (author's transl)]. Zeitschrift fur Hautkrankheiten, 1978, May-15, Volume: 53, Issue:10 Topics: Adrenal Cortex Hormones; Adult; Aged; Allopurinol; Aspirin; Humans; Lupus Erythematosus, Systemic; M	1978
Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Annals of internal medicine, 1978, Volume: 89, Issue:3 Topics: Adult; Aspirin; Blood Urea Nitrogen; Creatinine; Female; Humans; Inulin; Kidney; Lupus Erythematosus	1978
Salicylate hepatotoxicity in systemic lupus erythematosus: a common occurrence? British medical journal, 1978, Dec-02, Volume: 2, Issue:6151 Topics: Aspirin; Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Lupus Erythematosus,	1978
Aspirin-induced depression of renal function. The New England journal of medicine, 1977, Feb-24, Volume: 296, Issue:8 Topics: Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Blood Urea Nitrogen; Complement C3; Creatinine; Do	1977
[Presocyl in the treatment of lupus erythematosus]. Vestnik dermatologii i venerologii, 1976, Issue:7 Topics: Adolescent; Adult; Aspirin; Chloroquine; Drug Combinations; Female; Humans; Lupus Erythematosus, Dis	1976
Cerebral disorders of vision in systemic lupus erythematosus. Annals of internal medicine, 1975, Volume: 83, Issue:2 Topics: Adrenal Cortex Hormones; Adult; Aspirin; Brain Diseases; Cerebrospinal Fluid; Electroencephalography	1975
Aspirin hepatitis. American journal of diseases of children (1960), 1975, Volume: 129, Issue:12 Topics: Adolescent; Anemia, Sickle Cell; Arthritis, Juvenile; Aspartate Aminotransferases; Aspirin; Chemical	1975
Intravascular coagulation in acute lupus erythematosus. JAMA, 1975, Nov-03, Volume: 234, Issue:5 Topics: Acute Disease; Adult; Aspirin; Disseminated Intravascular Coagulation; Female; Headache; Hemolysis;	1975
Antiphospholipid antibodies in pregnancy. The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:4 Topics: Abortion, Habitual; Antibodies, Anticardiolipin; Aspirin; Female; Humans; Lupus Coagulation Inhibito	1992
[Severe hepatitis with encephalopathy induced by acetylsalicylic acid in a case of lupus erythematosus disseminatus]. Gastroenterologie clinique et biologique, 1992, Volume: 16, Issue:4 Topics: Aspirin; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Lupus Eryth	1992
Immunoadsorbent plasmapheresis for a patient with antiphospholipid syndrome during pregnancy. Annals of the rheumatic diseases, 1992, Volume: 51, Issue:3 Topics: Adult; Antibodies; Antiphospholipid Syndrome; Aspirin; Cardiolipins; DNA; Female; Humans; Lupus Coag	1992
Obstetric performance in patients with the lupus anticoagulant and/or anticardiolipin antibodies. American journal of perinatology, 1992, Volume: 9, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Antiphospholipid Syndrome; Aspirin; Cardiolipins; Drug Therapy, Comb	1992
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Annals of internal medicine, 1992, Aug-15, Volume: 117, Issue:4 Topics: Aged; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Female; Follow-Up Studies; Hepa	1992
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Annals of internal medicine, 1992, Aug-15, Volume: 117, Issue:4 Topics: Aged; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Female; Follow-Up Studies; Hepa	1992
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Annals of internal medicine, 1992, Aug-15, Volume: 117, Issue:4 Topics: Aged; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Female; Follow-Up Studies; Hepa	1992
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Annals of internal medicine, 1992, Aug-15, Volume: 117, Issue:4 Topics: Aged; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; Female; Follow-Up Studies; Hepa	1992
Cerebral ischemia associated with anticardiolipin antibodies. Acta neurologica Scandinavica, 1992, Volume: 85, Issue:6 Topics: Adult; Aged; Antiphospholipid Syndrome; Aspirin; Autoantibodies; Brain Ischemia; Cardiolipins; Cereb	1992
Osteonecrosis of femoral head in SLE patient after short period of corticosteroid therapy--a case report. JPMA. The Journal of the Pakistan Medical Association, 1991, Volume: 41, Issue:8 Topics: Adolescent; Aspirin; Drug Combinations; Female; Femur Head Necrosis; Humans; Lupus Erythematosus, Sy	1991
[Aspirin and pregnancy]. Nederlands tijdschrift voor geneeskunde, 1990, Jun-09, Volume: 134, Issue:23 Topics: Aspirin; Blood Coagulation Factors; Female; Fetal Death; Fetal Growth Retardation; Humans; Hypertens	1990
[Clinical study and therapy of systemic lupus erythematosus and pregnancy]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1990, Oct-10, Volume: 79, Issue:10 Topics: Antibodies, Antinuclear; Aspirin; Female; Heparin; Humans; Infant, Newborn; Kidney Function Tests; L	1990
Fetal loss treatment in patients with antiphospholipid antibodies. Annals of the rheumatic diseases, 1989, Volume: 48, Issue:10 Topics: Abortion, Habitual; Aspirin; Autoantibodies; Blood Coagulation Factors; Female; Humans; Lupus Coagul	1989
Pregnancy loss with phospholipid antibodies: improved outcome with aspirin containing treatment. The Australian & New Zealand journal of obstetrics & gynaecology, 1989, Volume: 29, Issue:3 Pt 2 Topics: Abortion, Spontaneous; Antibodies; Aspirin; Female; Fetal Death; Humans; Lupus Erythematosus, System	1989
Fetal demise associated with lupus anticoagulant: clinical features and results of treatment. Gynecologic and obstetric investigation, 1989, Volume: 28, Issue:4 Topics: Adult; Aspirin; Autoantibodies; Blood Coagulation; Dipyridamole; Female; Heparin; Humans; Immunosupp	1989
Low-dose aspirin in pregnancy. Lancet (London, England), 1988, Feb-20, Volume: 1, Issue:8582 Topics: Aspirin; Female; Fetal Growth Retardation; Humans; Hypertension; Infant, Newborn; Lupus Erythematosu	1988
Prednisone does not prevent recurrent fetal death in women with antiphospholipid antibody. American journal of obstetrics and gynecology, 1989, Volume: 160, Issue:2 Topics: Aspirin; Autoantibodies; Female; Fetal Death; Humans; Lupus Erythematosus, Systemic; Phospholipids;	1989
[Aspirin in the treatment of inflammatory rheumatism in 1987]. La Revue du praticien, 1987, Oct-15, Volume: 37, Issue:41 Topics: Adult; Arthritis, Rheumatoid; Aspirin; Child; Humans; Inflammation; Lupus Erythematosus, Systemic; R	1987
Rheumatoid arthritis: diagnosis and management. Clinical symposia (Summit, N.J. : 1957), 1986, Volume: 38, Issue:2 Topics: Adolescent; Adult; Anti-Inflammatory Agents; Arthritis, Infectious; Arthritis, Juvenile; Arthritis,	1986
Patterns of in vitro aspirin hydrolysis rates in rheumatoid arthritis and systemic lupus erythematosus. The Journal of rheumatology, 1986, Volume: 13, Issue:5 Topics: Arthritis, Rheumatoid; Aspirin; Erythrocytes; Hematocrit; Humans; Hydrolysis; Lupus Erythematosus, S	1986
Acute granulocytic leukemia following systemic lupus erythematosus. The American journal of the medical sciences, 1985, Volume: 290, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Aged; Aspirin; Cyclophosphamide; Cytarabine; Humans; Immunosuppressi	1985
Reye syndrome associated with aspirin therapy for systemic lupus erythematosus. Pediatrics, 1985, Volume: 76, Issue:2 Topics: Adolescent; Ammonia; Aspartate Aminotransferases; Aspirin; Biopsy, Needle; Electroencephalography; F	1985
Anti-inflammatory therapy during pregnancy and lactation. Clinical and investigative medicine. Medecine clinique et experimentale, 1985, Volume: 8, Issue:4 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Female; Humans; I	1985
Systemic lupus erythematosus in the elderly. Archives of internal medicine, 1972, Volume: 130, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Aspirin; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Ag	1972
Letter: Serum-transaminase levels and salicylates. Lancet (London, England), 1974, Nov-09, Volume: 2, Issue:7889 Topics: Adult; Alkaline Phosphatase; Aspirin; Female; Humans; Liver; Lupus Erythematosus, Systemic; Middle A	1974
The problem of drug hypersensitivity. Guy's Hospital reports, 1971, Volume: 120, Issue:3 Topics: Antibody Formation; Aspirin; Cell Migration Inhibition; Drug Hypersensitivity; Haptens; Hemagglutina	1971
Anti-inflammatory drugs in rheumatic diseases. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin	1974
The early natural history of juvenile rheumatoid arthritis. A 10-year follow-up study of 100 cases. The Medical clinics of North America, 1968, Volume: 52, Issue:3 Topics: Adolescent; Antimalarials; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Diagnosis, Differe	1968
Lung disease caused by drugs. British medical journal, 1969, Sep-27, Volume: 3, Issue:5673 Topics: Aspirin; Asthma; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Eosinophilia	1969
Which drugs for which rheumatic disorder? British medical journal, 1972, Apr-01, Volume: 2, Issue:5804 Topics: Analgesics; Arthritis, Rheumatoid; Aspirin; Gold; Gout; Humans; Indomethacin; Lupus Erythematosus, S	1972
Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. Annals of internal medicine, 1974, Volume: 80, Issue:1 Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Aspirin; Biopsy; Chemical and Drug Induced	1974
Aspirin hepatitis. Annals of internal medicine, 1974, Volume: 80, Issue:1 Topics: Adult; Aspirin; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests;	1974
Esophageal motility in systemic lupus erythematosus. The American journal of digestive diseases, 1974, Volume: 19, Issue:2 Topics: Adolescent; Adult; Aged; Aspirin; Azathioprine; Chloroquine; Deglutition Disorders; Dilatation; Drug	1974
Letter: Aspirin hepatotoxicity. Annals of internal medicine, 1974, Volume: 80, Issue:6 Topics: Adolescent; Aspirin; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lupus Erythemato	1974
Letter: Aspirin hepatotoxicity. Annals of internal medicine, 1974, Volume: 81, Issue:2 Topics: Aspirin; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Diseases; Liver Function Tests	1974
General considerations in the treatment of systemic lupus erythematosus. Mayo Clinic proceedings, 1969, Volume: 44, Issue:9 Topics: Adrenal Cortex Hormones; Allergens; Antimalarials; Aspirin; Contraception; Contraceptives, Oral; Fem	1969

aspirin and Lupus Erythematosus, Systemic

Research Excerpts

Research

Studies (199)

Authors

Clinical Trials (7)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Sairam, S	1
Sureen, A	1
Gutierrez, J	1
Dang, TQ	1
Mishra, K	1
Udry, S	1
Peréz, SM	1
Belizna, C	1
Aranda, F	1
Esteve-Valverde, E	1
Wingeyer, SP	1
Fernández-Romero, DS	1
Latino, JO	1
de Larrañaga, G	1
Alijotas-Reig, J	3
Tani, C	1
Zucchi, D	1
Haase, I	1
Gerosa, M	2
Larosa, M	1
Cavagna, L	1
Bortoluzzi, A	1
Crisafulli, F	1
Mucke, J	1
Strigini, FAL	1
Baglietto, L	1
Fornili, M	1
Monacci, F	1
Elefante, E	1
Erra, R	1
Bellis, E	1
Padovan, M	1
Andreoli, L	3
Coletto, LA	1
Zanframundo, G	1
Govoni, M	1
Iaccarino, L	1
Tincani, A	6
Doria, A	2
Fischer-Betz, R	1
Mosca, M	4
Silver, R	1
Craigo, S	1
Porter, F	1
Osmundson, SS	1
Kuller, JA	1
Norton, ME	1
Zhang, N	3
Zhang, HX	3
Li, YW	3
Li, Y	4
Tao, JJ	1
Adurty, S	1
D'Angelo, D	1
DeSancho, MT	1
Chen, X	2
Di, W	1
Ye, L	1
Hu, Y	1
Jiang, M	1
Wu, J	1
Bu, J	1
Sun, J	1
Bei, F	1
Eudy, AM	1
Voora, D	1
Myers, RA	1
Clowse, MEB	1
Mueller, AA	1
Vaidya, A	1
Tarter, LL	1
Klein, JP	1
Barkoudah, E	1
Chavatza, K	1
Kostopoulou, M	1
Nikolopoulos, D	1
Gioti, O	1
Togia, K	1
Aringer, M	1
Boletis, J	1
Houssiau, FA	1
Jayne, D	1
Svenungsson, E	1
Bertsias, G	1
Fanouriakis, A	1
Boumpas, DT	1
Li, X	1
Shopit, A	1
Wang, J	1
Vinay, K	1
Sawatkar, G	1
Dogra, S	1
Saikia, UN	1
Fasano, S	3
Pierro, L	2
Pantano, I	3
Iudici, M	2
Valentini, G	3
Riancho-Zarrabeitia, L	1
Daroca, G	1
Muñoz, P	1
López-Hoyos, M	1
Haya, A	1
Martínez-Taboada, VM	1
Margiotta, DP	1
Navarini, L	1
Riccardi, A	1
Afeltra, A	1
Mahajan, K	1
Negi, P	1
Merwaha, R	1
Sharma, M	1
Kötter, I	1
Stübiger, N	1
Deuter, C	1
Nkeck, JR	1
Endomba, FTA	1
Ndoadoumgue, AL	1
Kalbassou, FB	1
Chen, WL	1
Liu, YD	1
Li, XL	1
Feng, SX	1
Zhou, XY	1
Ma, WX	1
Ye, DS	1
Chen, SL	1
Mazur-Nicorici, L	1
Sadovici-Bobeica, V	1
Garabajiu, M	1
Mazur, M	1
de Moreuil, C	1
Fauchais, AL	1
Merviel, P	1
Tremouilhac, C	1
Le Moigne, E	1
Pasquier, E	1
Pan-Petesch, B	1
Lacut, K	1
Quintanilla-González, L	1
Torres-Villalobos, G	1
Hinojosa-Azaola, A	1
Mendel, A	1
Bernatsky, SB	1
Hanly, JG	1
Urowitz, MB	2
Clarke, AE	1
Romero-Diaz, J	1
Gordon, C	2
Bae, SC	1
Wallace, DJ	1
Merrill, JT	2
Buyon, JP	2
Isenberg, DA	2
Rahman, A	3
Ginzler, EM	1
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Kim, MY	1
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