Page last updated: 2024-10-23

aspirin and Local Neoplasm Recurrence

aspirin has been researched along with Local Neoplasm Recurrence in 95 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM)."9.41Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial. ( Angelsen, JH; Bjørnbeth, BA; Fristrup, CW; Grønbech, JE; Hemmingsson, O; Isaksson, B; Juel, IS; Larsen, PN; Lindell, G; Mortensen, FV; Mortensen, KE; Rizell, M; Sandström, P; Sandvik, OM; Sparrelid, E; Taflin, H; Taskén, K; Yaqub, S, 2021)
" Several epidemiological studies have shown that regular use of low dose aspirin is associated with a 20 to 30% reduction in the risk of sporadic colonic adenomas and colorectal cancer regardless of family risk."9.34Effect of chemoprevention by low-dose aspirin of new or recurrent colorectal adenomas in patients with Lynch syndrome (AAS-Lynch): study protocol for a multicenter, double-blind, placebo-controlled randomized controlled trial. ( Ait-Omar, A; Benallaoua, M; Benamouzig, R; Boubaya, M; Deutsch, D; Helfen, S; Levy, V; Mary, F; Soualy, A, 2020)
"In a prospective study, the combination of calcitriol, aspirin, and calcium carbonate did not prevent recurrence of colorectal adenomas over a 3-year period."9.22Aspirin, Calcitriol, and Calcium Do Not Prevent Adenoma Recurrence in a Randomized Controlled Trial. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2016)
"Aspirin has been shown to protect against colorectal neoplasms; however, the optimal chemopreventive dose and underlying mechanisms are unclear."9.20Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS). ( Ahnen, DJ; Baron, JA; Barry, EL; Bradshaw, PT; Bresalier, RS; Fedirko, V; Figueiredo, JC; Milne, GL; Sandler, RS, 2015)
"Study subjects, about half of whom were recruited after fortification of grain products with folic acid in the United States and Canada, consisted of 871 individuals with a recent history of one or more colorectal adenomas who were randomized to receive either a 1 mg/day folic acid supplement or a placebo within one of three randomly assigned aspirin treatment groups (placebo, 81, or 325 mg/day)."9.14Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation. ( Baron, JA; Grau, MV; Levine, AJ; Mott, LA; Ueland, PM, 2010)
"Low-dose aspirin reduces the incidence of colorectal cancer and recurrence of adenomas."9.14Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention. ( Benamouzig, R; Chaussade, S; Deyra, J; Girard, B; Little, J; Martin, A; Uzzan, B, 2010)
" Aspirin inhibits COX-2 activity and lowers the risk for colorectal adenomas and cancer."9.14Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. ( Ahnen, DJ; Ali, IU; Baron, JA; Barry, EL; Bresalier, RS; Burke, C; Grau, MV; Gui, J; McKeown-Eyssen, GE; Munroe, DJ; Saibil, F; Sandler, RS; Sansbury, LB; Tsang, S, 2009)
"The Aspirin/Folate Polyp Prevention Study is a randomized clinical trial of folic acid supplementation and incidence of new colorectal adenomas in individuals with a history of adenomas (n = 1,084)."9.13Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. ( Ahnen, DJ; Ali, I; Baron, JA; Barry, EL; Figueiredo, JC; Grau, MV; Haile, RW; Levine, AJ; Midttun, O; Munroe, D; Sandler, RS; Tsang, S; Ueland, PM, 2008)
"8%) of 434 patients receiving aspirin had a recurrent adenoma compared with 121 (28."9.13Aspirin and folic acid for the prevention of recurrent colorectal adenomas. ( Armitage, NC; Grainge, MJ; Logan, RF; Muir, KR; Shepherd, VC, 2008)
" The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of aspirin on colorectal cancer and/or colorectal adenomas."9.12Does aspirin reduce the incidence, recurrence, and mortality of colorectal cancer? A meta-analysis of randomized clinical trials. ( Bhan, C; Cao, C; Cheng, C; Guo, Z; Han, T; Ji, Z; Ma, S; Qu, G; Sun, C; Yan, Y; Yang, H; Zhang, H; Zhou, Q, 2021)
"The purpose of this study is to investigate whether aspirin improves the prognosis of breast cancer patients by meta analysis."9.12Effect of aspirin use on survival benefits of breast cancer patients: A meta-analysis. ( Liu, A; Liu, J; Wu, X; Yang, M; Zheng, F, 2021)
"Among the 238 patients who completed the year 1 colonoscopy, at least one adenoma was observed in 38 patients of the 126 (30%) in the aspirin group and in 46 of the 112 (41%) in the placebo group; relative risk was 0."9.10Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. ( Benamouzig, R; Chaussade, S; Coste, T; Couturier, D; Deyra, J; Girard, B; Jullian, E; Little, J; Martin, A; Piednoir, B, 2003)
" A multicentre, double-blind, randomized, controlled trial is underway to determine the efficacy of regular aspirin intake (160 or 300 mg/day) in reducing colorectal adenoma recurrence."9.09APACC, a French prospective study on aspirin efficacy in reducing colorectal adenoma recurrence: design and baseline findings. ( Benamouzig, R; Chaussade, S; Coste, T; Couturier, D; Deyra, J; Little, J; Martin, A; Yoon, H, 2001)
"In patients with a previous history of colorectal cancer or adenomas, low-dose aspirin (80-160 mg/day) compared to placebo taken for 2 to 4 years reduces the risk of recurrent colorectal adenomas (relative risk (RR), 0."8.95Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials. ( Chaiyakunapruk, N; Ching, SM; Lim, KG; Phisalprapa, P; Saokaew, S; Veettil, SK, 2017)
"Through search the possible randomized control trials, we make a renewed meta-analysis in order to assess the impact of aspirin in preventing the recurrence of colorectal adenoma."8.93The Efficacy of Aspirin in Preventing the Recurrence of Colorectal Adenoma: a Renewed Meta-Analysis of Randomized Trials. ( Cheng, DW; Gao, XK; Lu, XJ; Luo, H; Tu, J; Wang, Y; Wang, YJ; Xu, XL; Yan, BC; Zhang, HL; Zhao, TY, 2016)
"NSAIDs and aspirin after but not before diagnosis were associated with improved breast cancer survival, including breast-cancer-specific mortality, all-cause mortality, and relapse/metastasis."8.91Aspirin and nonsteroidal anti-inflammatory drugs after but not before diagnosis are associated with improved breast cancer survival: a meta-analysis. ( Chen, P; Chen, XW; Gao, P; Huang, XZ; Liu, J; Song, YX; Sun, JX; Tsai, CC; Wang, ZN; Xu, HM, 2015)
"This meta-analysis suggests that aspirin prevents recurrent colorectal adenomas among patients with a history of colorectal adenomas."8.85The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials. ( Cao, Y; Gao, F; Liao, C; Liu, L; Mo, Z; Tan, A, 2009)
"We combined data from all randomized double-blind placebo-controlled trials that evaluated aspirin for the prevention of colorectal adenomas."8.85Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. ( Baron, JA; Benamouzig, R; Chaussade, S; Cole, BF; Grainge, MJ; Halabi, S; Logan, RF; Sandler, RS, 2009)
"Randomised trials have shown that aspirin reduces the short-term risk of recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large trials have shown no effect in primary prevention of colorectal cancer during 10 years' follow-up."8.84Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. ( Flossmann, E; Rothwell, PM, 2007)
"To determine the impact of fibrin clot inhibitor (FCI) use on oncological outcomes in a large contemporary cohort of patients with non-muscle-invasive bladder cancer (NMIBC) treated with adequate bacille Calmette-Guérin (BCG)."8.12Should patients with non-muscle-invasive bladder cancer discontinue fibrin clot inhibitors during bacille Calmette-Guérin? ( Bree, KK; Dinney, CP; Hensley, PJ; Kamat, AM; Lobo, N; Navai, N; Nogueras-Gonzalez, GM, 2022)
" Here, we report the case of an 82-year-old Japanese woman with normal renal function who developed multiple cerebral infarctions due to CAT that grew rapidly, associated with inflammation from an antecedent infection, and diminished rapidly by detachment of fibrin on the mass surface and antithrombotic drugs."8.12Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report. ( Doyu, M; Ito, H; Kimura, M; Matsuyama, K; Niwa, JI, 2022)
" Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been associated with lower risk of breast cancer recurrence and mortality."7.96Different associations of tumor PIK3CA mutations and clinical outcomes according to aspirin use among women with metastatic hormone receptor positive breast cancer. ( Armstrong, K; Bardia, A; Chan, AT; He, W; Iafrate, AJ; Kumar, NP; McCarthy, AM; Moy, B; Regan, S; Welch, M, 2020)
"Aspirin use may have chemo-preventive effect on recurrence of hepatitis B virus-related HCC after curative resection."7.96Aspirin is associated with low recurrent risk in hepatitis B virus-related hepatocellular carcinoma patients after curative resection. ( Chao, Y; Chau, GY; Hou, MC; Huang, YH; Huo, TI; Lee, IC; Lee, MH; Lin, HC; Su, CW; Yeh, YC; Young, SH, 2020)
"Results from previous studies indicate that use of low-dose aspirin may improve breast cancer prognosis."7.88No association between low-dose aspirin use and breast cancer outcomes overall: a Swedish population-based study. ( Ekberg, S; Eloranta, S; Fredriksson, I; Frisk, G; Lambe, M; Lidbrink, E; Smedby, KE; Sund, M, 2018)
"Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective COX-2 inhibitors may improve outcomes in breast cancer patients."7.83Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence. ( Ahern, TP; Christiansen, P; Cronin-Fenton, DP; Ejlertsen, B; Heide-Jørgensen, U; Lash, TL; Sørensen, HT, 2016)
"The impact of statins, aspirin and metformin use on recurrence-free (RFS) and overall survival (OS) of patients with biliary tract cancer (BTC) has not been evaluated."7.81Effects of Statin, Aspirin or Metformin Use on Recurrence-Free and Overall Survival in Patients with Biliary Tract Cancer. ( Aneja, P; Horgan, AM; Knox, JJ; Le, LW; McKeever, E; McNamara, MG, 2015)
"This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, statins, or both drugs to untreated ones."7.81Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection. ( Al Salhi, Y; Carbone, A; Costantini, E; de Nunzio, C; Fuschi, A; Palleschi, G; Pastore, A; Petrozza, V; Silvestri, L; Zucchi, A, 2015)
"Recent observational studies showed that post-operative aspirin use reduces cancer relapse and death in the earliest stages of colorectal cancer."7.80Cost-effectiveness of aspirin adjuvant therapy in early stage colorectal cancer in older patients. ( Ali, R; Chan, ML; Chia, WK; Deng, YH; Ho, GF; Jian, X; Mehta, S; Segelov, E; Sharma, A; Soon, SS; Tan, CS; Toh, HC; Wee, HL, 2014)
"Recent observational studies suggest that postoperative aspirin use may improve Colorectal cancer (CRC)-specific survival and overall survival (OS)."7.80Post-operative aspirin use and colorectal cancer-specific survival in patients with stage I-III colorectal cancer. ( Chew, L; Chew, MH; Chia, WK; Fu, WP; Goh, CH; Goh, HH; Leong, WQ; Pan, YS; Tan, IB; Tang, CL; Toh, HC; Tony, LK, 2014)
"Aspirin is associated with a reduced risk of developing colorectal cancer."7.79Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality. ( Donnan, PT; McCowan, C; Munro, AJ; Steele, RJ, 2013)
"To evaluate the recurrence-free survival (RFS) rate of patients taking cardioprotective aspirin after intravesical bacille Calmette-Guérin (BCG) for high-grade noninvasive urothelial carcinoma of the bladder, as preventing the recurrence of superficial bladder cancer might decrease patient morbidity and mortality from this disease, and nonsteroidal anti-inflammatory agents (NSAIDs) have shown promise in preclinical prevention through inhibition of the prostaglandin pathway and other mechanisms."7.75Reduced bladder cancer recurrence rate with cardioprotective aspirin after intravesical bacille Calmette-Guérin. ( Bruskewitz, RC; Gee, JR; Hedican, SP; Jarrard, DF; Leverson, GE; Messing, EM; Moon, TD; Nakada, SY, 2009)
"We genotyped ODC G316A in 546 individuals in the United Kingdom Colorectal Adenoma Prevention trial of aspirin for CRA recurrence prevention and pooled our findings with data from two other randomized intervention trials."7.74Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. ( Grainge, MJ; Houlston, RS; Hubner, RA; Liu, JF; Logan, RF; Muir, KR, 2008)
"Aspirin intolerance (AI) is characterized by polypous rhinosinusitis, bronchial asthma and adverse reactions to aspirin."7.70Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics. ( Göde, U; Schäfer, D; Schmid, M; Wigand, ME, 1999)
"However, the prognosis of stage III colorectal cancer is still poor even after curative resection and adjuvant chemotherapy."6.90Efficacy of aspirin for stage III colorectal cancer: a randomized double-blind placebo-controlled trial (JCOG1503C, EPISODE-III trial). ( Fukuda, H; Hamaguchi, T; Kanemitsu, Y; Katayama, H; Miyamoto, K; Mizusawa, J; Nakamura, K; Sato, Y; Shibata, T; Shida, D; Shimada, Y; Takashima, A, 2019)
"Chemoprevention of colorectal cancer involves the long-term use of pharmacologic agents that can prevent neoplasms from developing in the large bowel."6.43Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer. ( Benamouzig, R; Chaussade, S; Little, J; Uzzan, B, 2005)
"The aim of this study was to determine the effect of smoking status on subsequent stroke risk in patients with minor ischemic stroke or TIA and to determine whether smoking modifies the effect of clopidogrel-based DAPT on subsequent stroke risk."5.69Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial. ( de Havenon, A; Easton, JD; Furie, KL; Henninger, N; Johnston, SC; Kim, A; Lang, AE; Mac Grory, B; Shu, L; Yaghi, S, 2023)
"The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM)."5.41Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial. ( Angelsen, JH; Bjørnbeth, BA; Fristrup, CW; Grønbech, JE; Hemmingsson, O; Isaksson, B; Juel, IS; Larsen, PN; Lindell, G; Mortensen, FV; Mortensen, KE; Rizell, M; Sandström, P; Sandvik, OM; Sparrelid, E; Taflin, H; Taskén, K; Yaqub, S, 2021)
"The occurrence of metastasis was ascertained monthly by a qualified oncologist, and confirmed, if necessary, by biopsy."5.36Acetyl salicylic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients [corrected]. ( Bhattacharyya, M; Chakraborty, S; Ghosh, R; Girish, GV; Sinha, AK, 2010)
" Several epidemiological studies have shown that regular use of low dose aspirin is associated with a 20 to 30% reduction in the risk of sporadic colonic adenomas and colorectal cancer regardless of family risk."5.34Effect of chemoprevention by low-dose aspirin of new or recurrent colorectal adenomas in patients with Lynch syndrome (AAS-Lynch): study protocol for a multicenter, double-blind, placebo-controlled randomized controlled trial. ( Ait-Omar, A; Benallaoua, M; Benamouzig, R; Boubaya, M; Deutsch, D; Helfen, S; Levy, V; Mary, F; Soualy, A, 2020)
"In a prospective study, the combination of calcitriol, aspirin, and calcium carbonate did not prevent recurrence of colorectal adenomas over a 3-year period."5.22Aspirin, Calcitriol, and Calcium Do Not Prevent Adenoma Recurrence in a Randomized Controlled Trial. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2016)
"Aspirin has been shown to protect against colorectal neoplasms; however, the optimal chemopreventive dose and underlying mechanisms are unclear."5.20Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS). ( Ahnen, DJ; Baron, JA; Barry, EL; Bradshaw, PT; Bresalier, RS; Fedirko, V; Figueiredo, JC; Milne, GL; Sandler, RS, 2015)
" Aspirin or heparin was recommended for patients at high thrombosis risk."5.20Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance). ( Bartlett, NL; Blum, KA; Cheson, BD; Czuczman, M; Giguere, JK; Johnson, J; Jung, SH; Leonard, JP; Pitcher, BN, 2015)
"311 subjects with single/multiple colorectal adenomas and adenocarcinomas excised by endoscopy were enrolled in the study (152 patients in the aspirin group and 159 patients in the placebo group)."5.19The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. ( Abe, T; Gondo, N; Goto, C; Iimuro, M; Ishikawa, H; Joh, T; Kitamura, S; Kudo, SE; Kusunoki, M; Lee, K; Matsuda, T; Matsuura, N; Mizuno, M; Mutoh, M; Okamura, S; Saida, Y; Sakai, T; Sano, Y; Sato, Y; Sugimoto, K; Suzuki, S; Tajika, M; Takayama, T; Tanaka, S; Tokudome, S; Wakabayashi, K; Yukawa, T, 2014)
"Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) and are associated with reduced disease recurrence and improved outcome after primary treatment."5.17Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. ( Church, DN; Davidson, B; Domingo, E; Johnstone, E; Kerr, DJ; Midgley, R; Ramamoorthy, R; Sieber, O; Tomlinson, IP; Yanagisawa, Y, 2013)
"Study subjects, about half of whom were recruited after fortification of grain products with folic acid in the United States and Canada, consisted of 871 individuals with a recent history of one or more colorectal adenomas who were randomized to receive either a 1 mg/day folic acid supplement or a placebo within one of three randomly assigned aspirin treatment groups (placebo, 81, or 325 mg/day)."5.14Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation. ( Baron, JA; Grau, MV; Levine, AJ; Mott, LA; Ueland, PM, 2010)
" Aspirin inhibits COX-2 activity and lowers the risk for colorectal adenomas and cancer."5.14Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. ( Ahnen, DJ; Ali, IU; Baron, JA; Barry, EL; Bresalier, RS; Burke, C; Grau, MV; Gui, J; McKeown-Eyssen, GE; Munroe, DJ; Saibil, F; Sandler, RS; Sansbury, LB; Tsang, S, 2009)
"Low-dose aspirin reduces the incidence of colorectal cancer and recurrence of adenomas."5.14Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention. ( Benamouzig, R; Chaussade, S; Deyra, J; Girard, B; Little, J; Martin, A; Uzzan, B, 2010)
"The Aspirin/Folate Polyp Prevention Study is a randomized clinical trial of folic acid supplementation and incidence of new colorectal adenomas in individuals with a history of adenomas (n = 1,084)."5.13Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. ( Ahnen, DJ; Ali, I; Baron, JA; Barry, EL; Figueiredo, JC; Grau, MV; Haile, RW; Levine, AJ; Midttun, O; Munroe, D; Sandler, RS; Tsang, S; Ueland, PM, 2008)
" We assessed the association between two common MTHFR variants, 677C>T and 1298A>C, and adenoma recurrence in the context of a randomized double- blind clinical trial of aspirin use and folate supplementation."5.13MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial. ( Ahnen, D; Ali, IU; Baron, JA; Barry, EL; Cole, BF; Haile, RW; Levine, AJ; Munroe, DJ; Saibil, F; Tsang, S; Ueland, P; Wallace, K, 2008)
"8%) of 434 patients receiving aspirin had a recurrent adenoma compared with 121 (28."5.13Aspirin and folic acid for the prevention of recurrent colorectal adenomas. ( Armitage, NC; Grainge, MJ; Logan, RF; Muir, KR; Shepherd, VC, 2008)
"The purpose of this study is to investigate whether aspirin improves the prognosis of breast cancer patients by meta analysis."5.12Effect of aspirin use on survival benefits of breast cancer patients: A meta-analysis. ( Liu, A; Liu, J; Wu, X; Yang, M; Zheng, F, 2021)
" The pooled relative risk (RR) with 95% confidence interval (CI) was used to estimate the effect of aspirin on colorectal cancer and/or colorectal adenomas."5.12Does aspirin reduce the incidence, recurrence, and mortality of colorectal cancer? A meta-analysis of randomized clinical trials. ( Bhan, C; Cao, C; Cheng, C; Guo, Z; Han, T; Ji, Z; Ma, S; Qu, G; Sun, C; Yan, Y; Yang, H; Zhang, H; Zhou, Q, 2021)
" Functional polymorphisms of UGT1A6 (T181A and R184S) and CYP2C9 (R144C and I359L) have been reported to modify the protective effect of aspirin on colorectal adenoma risk."5.12Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence. ( Armitage, N; Grainge, M; Houlston, RS; Hubner, RA; Liu, JF; Logan, RF; Muir, KR; Popat, S; Shepherd, V, 2006)
"Among the 238 patients who completed the year 1 colonoscopy, at least one adenoma was observed in 38 patients of the 126 (30%) in the aspirin group and in 46 of the 112 (41%) in the placebo group; relative risk was 0."5.10Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. ( Benamouzig, R; Chaussade, S; Coste, T; Couturier, D; Deyra, J; Girard, B; Jullian, E; Little, J; Martin, A; Piednoir, B, 2003)
" A multicentre, double-blind, randomized, controlled trial is underway to determine the efficacy of regular aspirin intake (160 or 300 mg/day) in reducing colorectal adenoma recurrence."5.09APACC, a French prospective study on aspirin efficacy in reducing colorectal adenoma recurrence: design and baseline findings. ( Benamouzig, R; Chaussade, S; Coste, T; Couturier, D; Deyra, J; Little, J; Martin, A; Yoon, H, 2001)
"In patients with a previous history of colorectal cancer or adenomas, low-dose aspirin (80-160 mg/day) compared to placebo taken for 2 to 4 years reduces the risk of recurrent colorectal adenomas (relative risk (RR), 0."4.95Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials. ( Chaiyakunapruk, N; Ching, SM; Lim, KG; Phisalprapa, P; Saokaew, S; Veettil, SK, 2017)
"Through search the possible randomized control trials, we make a renewed meta-analysis in order to assess the impact of aspirin in preventing the recurrence of colorectal adenoma."4.93The Efficacy of Aspirin in Preventing the Recurrence of Colorectal Adenoma: a Renewed Meta-Analysis of Randomized Trials. ( Cheng, DW; Gao, XK; Lu, XJ; Luo, H; Tu, J; Wang, Y; Wang, YJ; Xu, XL; Yan, BC; Zhang, HL; Zhao, TY, 2016)
"NSAIDs and aspirin after but not before diagnosis were associated with improved breast cancer survival, including breast-cancer-specific mortality, all-cause mortality, and relapse/metastasis."4.91Aspirin and nonsteroidal anti-inflammatory drugs after but not before diagnosis are associated with improved breast cancer survival: a meta-analysis. ( Chen, P; Chen, XW; Gao, P; Huang, XZ; Liu, J; Song, YX; Sun, JX; Tsai, CC; Wang, ZN; Xu, HM, 2015)
"This meta-analysis suggests that aspirin prevents recurrent colorectal adenomas among patients with a history of colorectal adenomas."4.85The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials. ( Cao, Y; Gao, F; Liao, C; Liu, L; Mo, Z; Tan, A, 2009)
"We combined data from all randomized double-blind placebo-controlled trials that evaluated aspirin for the prevention of colorectal adenomas."4.85Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. ( Baron, JA; Benamouzig, R; Chaussade, S; Cole, BF; Grainge, MJ; Halabi, S; Logan, RF; Sandler, RS, 2009)
"Randomised trials have shown that aspirin reduces the short-term risk of recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large trials have shown no effect in primary prevention of colorectal cancer during 10 years' follow-up."4.84Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. ( Flossmann, E; Rothwell, PM, 2007)
" Here, we report the case of an 82-year-old Japanese woman with normal renal function who developed multiple cerebral infarctions due to CAT that grew rapidly, associated with inflammation from an antecedent infection, and diminished rapidly by detachment of fibrin on the mass surface and antithrombotic drugs."4.12Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report. ( Doyu, M; Ito, H; Kimura, M; Matsuyama, K; Niwa, JI, 2022)
"To determine the impact of fibrin clot inhibitor (FCI) use on oncological outcomes in a large contemporary cohort of patients with non-muscle-invasive bladder cancer (NMIBC) treated with adequate bacille Calmette-Guérin (BCG)."4.12Should patients with non-muscle-invasive bladder cancer discontinue fibrin clot inhibitors during bacille Calmette-Guérin? ( Bree, KK; Dinney, CP; Hensley, PJ; Kamat, AM; Lobo, N; Navai, N; Nogueras-Gonzalez, GM, 2022)
" Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been associated with lower risk of breast cancer recurrence and mortality."3.96Different associations of tumor PIK3CA mutations and clinical outcomes according to aspirin use among women with metastatic hormone receptor positive breast cancer. ( Armstrong, K; Bardia, A; Chan, AT; He, W; Iafrate, AJ; Kumar, NP; McCarthy, AM; Moy, B; Regan, S; Welch, M, 2020)
"Aspirin use may have chemo-preventive effect on recurrence of hepatitis B virus-related HCC after curative resection."3.96Aspirin is associated with low recurrent risk in hepatitis B virus-related hepatocellular carcinoma patients after curative resection. ( Chao, Y; Chau, GY; Hou, MC; Huang, YH; Huo, TI; Lee, IC; Lee, MH; Lin, HC; Su, CW; Yeh, YC; Young, SH, 2020)
"Our findings suggest that concurrent use of glucocorticoids, ACE inhibitors, aspirin, NSAIDs, selective COX-2 inhibitors, digoxin, and opioids has little impact on breast cancer recurrence."3.88Concurrent new drug prescriptions and prognosis of early breast cancer: studies using the Danish Breast Cancer Group clinical database. ( Ahern, TP; Christiansen, P; Cronin-Fenton, D; Damkier, P; Ejlertsen, B; Lash, TL; Sørensen, HT, 2018)
"Results from previous studies indicate that use of low-dose aspirin may improve breast cancer prognosis."3.88No association between low-dose aspirin use and breast cancer outcomes overall: a Swedish population-based study. ( Ekberg, S; Eloranta, S; Fredriksson, I; Frisk, G; Lambe, M; Lidbrink, E; Smedby, KE; Sund, M, 2018)
"Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective COX-2 inhibitors may improve outcomes in breast cancer patients."3.83Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence. ( Ahern, TP; Christiansen, P; Cronin-Fenton, DP; Ejlertsen, B; Heide-Jørgensen, U; Lash, TL; Sørensen, HT, 2016)
"The impact of statins, aspirin and metformin use on recurrence-free (RFS) and overall survival (OS) of patients with biliary tract cancer (BTC) has not been evaluated."3.81Effects of Statin, Aspirin or Metformin Use on Recurrence-Free and Overall Survival in Patients with Biliary Tract Cancer. ( Aneja, P; Horgan, AM; Knox, JJ; Le, LW; McKeever, E; McNamara, MG, 2015)
"This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, statins, or both drugs to untreated ones."3.81Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection. ( Al Salhi, Y; Carbone, A; Costantini, E; de Nunzio, C; Fuschi, A; Palleschi, G; Pastore, A; Petrozza, V; Silvestri, L; Zucchi, A, 2015)
"Recent observational studies suggest that postoperative aspirin use may improve Colorectal cancer (CRC)-specific survival and overall survival (OS)."3.80Post-operative aspirin use and colorectal cancer-specific survival in patients with stage I-III colorectal cancer. ( Chew, L; Chew, MH; Chia, WK; Fu, WP; Goh, CH; Goh, HH; Leong, WQ; Pan, YS; Tan, IB; Tang, CL; Toh, HC; Tony, LK, 2014)
"Recent observational studies showed that post-operative aspirin use reduces cancer relapse and death in the earliest stages of colorectal cancer."3.80Cost-effectiveness of aspirin adjuvant therapy in early stage colorectal cancer in older patients. ( Ali, R; Chan, ML; Chia, WK; Deng, YH; Ho, GF; Jian, X; Mehta, S; Segelov, E; Sharma, A; Soon, SS; Tan, CS; Toh, HC; Wee, HL, 2014)
"Aspirin is associated with a reduced risk of developing colorectal cancer."3.79Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality. ( Donnan, PT; McCowan, C; Munro, AJ; Steele, RJ, 2013)
"To determine if there is a difference in clinical outcomes among non-muscle-invasive bladder cancer patients taking fibrin clot-inhibiting (FCI) medications (aspirin, clopidogrel, or warfarin) while receiving Bacillus Calmette-Guérin (BCG) therapy compared with their counterparts not taking anticoagulation."3.79The effect of fibrin clot inhibitors on the immunomodulatory efficacy of Bacillus Calmette-Guérin therapy for non-muscle-invasive bladder cancer. ( Badalato, GM; Hruby, GW; Lipsky, MJ; McKiernan, JM; Motamedinia, P, 2013)
"To evaluate the recurrence-free survival (RFS) rate of patients taking cardioprotective aspirin after intravesical bacille Calmette-Guérin (BCG) for high-grade noninvasive urothelial carcinoma of the bladder, as preventing the recurrence of superficial bladder cancer might decrease patient morbidity and mortality from this disease, and nonsteroidal anti-inflammatory agents (NSAIDs) have shown promise in preclinical prevention through inhibition of the prostaglandin pathway and other mechanisms."3.75Reduced bladder cancer recurrence rate with cardioprotective aspirin after intravesical bacille Calmette-Guérin. ( Bruskewitz, RC; Gee, JR; Hedican, SP; Jarrard, DF; Leverson, GE; Messing, EM; Moon, TD; Nakada, SY, 2009)
"We genotyped ODC G316A in 546 individuals in the United Kingdom Colorectal Adenoma Prevention trial of aspirin for CRA recurrence prevention and pooled our findings with data from two other randomized intervention trials."3.74Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. ( Grainge, MJ; Houlston, RS; Hubner, RA; Liu, JF; Logan, RF; Muir, KR, 2008)
"Aspirin intolerance (AI) is characterized by polypous rhinosinusitis, bronchial asthma and adverse reactions to aspirin."3.70Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics. ( Göde, U; Schäfer, D; Schmid, M; Wigand, ME, 1999)
"However, the prognosis of stage III colorectal cancer is still poor even after curative resection and adjuvant chemotherapy."2.90Efficacy of aspirin for stage III colorectal cancer: a randomized double-blind placebo-controlled trial (JCOG1503C, EPISODE-III trial). ( Fukuda, H; Hamaguchi, T; Kanemitsu, Y; Katayama, H; Miyamoto, K; Mizusawa, J; Nakamura, K; Sato, Y; Shibata, T; Shida, D; Shimada, Y; Takashima, A, 2019)
"Add-Aspirin is a phase III, multi-centre, double-blind, placebo-controlled randomised trial with four parallel cohorts."2.82ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours. ( Berkman, L; Cafferty, FH; Cameron, D; Coyle, C; Gilbert, D; Gupta, S; Kynaston, H; Langley, RE; MacKenzie, M; Pramesh, CS; Ring, A; Rowley, S; Wilson, RH, 2016)
"Aspirin is a commonly used medication with anti-inflammatory and analgesic properties, and it is widely used to reduce the risk of ischaemic heart disease-related events and/or cerebrovascular accidents."2.72The multiple effects of aspirin in prostate cancer patients. ( Bryant, RJ; Joshi, SN; Murphy, EA; Olaniyi, P, 2021)
"Metformin use was associated with a significantly higher overall and disease-free survival, in a subset of diabetic patients."2.55Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy. ( Chambers, AC; Cotton, DE; Gash, KJ; Thomas, MG; Williams, AC, 2017)
"Breast cancer is the most common cancer in women worldwide."2.52Update on breast cancer risk prediction and prevention. ( Cuzick, J; Sestak, I, 2015)
"Chemoprevention of colorectal cancer involves the long-term use of pharmacologic agents that can prevent neoplasms from developing in the large bowel."2.43Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer. ( Benamouzig, R; Chaussade, S; Little, J; Uzzan, B, 2005)
" As well, we highlight current research around optimal dosage and other issues related to aspirin administration."2.43What every emergency nurse needs to know about aspirin. ( Smith, S; Turris, SA, 2005)
"In addition to residual cancer cells, the surgery resection-induced hyperinflammatory microenvironment is a key factor that leads to postsurgical cancer recurrence."1.91Aspirin-Loaded Cross-Linked Lipoic Acid Nanodrug Prevents Postoperative Tumor Recurrence by Residual Cancer Cell Killing and Inflammatory Microenvironment Improvement. ( Chen, Y; Jing, P; Liao, C; Luo, Y; Tan, J; Zhang, S, 2023)
"Aspirin or NSAID use was considered positive if the patients were receiving aspirin or NSAID medication from HNSCC diagnosis to at least 1 year after treatment initiation."1.48Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up. ( Choi, SH; Kim, SA; Kim, SB; Kim, SY; Nam, SY; Roh, JL, 2018)
"Aspirin users were significantly older, more likely to have a history of cardiovascular disease and diabetes, and more likely to use metformin or statin (each p <0."1.48The Association of Aspirin Use with Survival Following Radical Cystectomy. ( Boorjian, SA; Cheville, JC; Frank, I; Karnes, RJ; Lyon, TD; Shah, PH; Tarrell, R; Thompson, RH; Tollefson, MK, 2018)
"Recurrence of hepatocellular carcinoma (HCC) with unsatisfactory survival is common after surgical resection."1.43Antiplatelet Therapy is Associated with a Better Prognosis for Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma after Liver Resection. ( Chao, Y; Chen, CC; Chen, TJ; Hu, YW; Huang, YH; Huo, TI; Lee, PC; Lin, HC; Liu, CJ; Su, CW; Wu, JC; Yeh, CM, 2016)
" Further study is needed to confirm these findings and to determine the optimal dosing and schedule, as well as the relative benefits and risks, of both therapies in combination with RT."1.38Aspirin and statin nonuse associated with early biochemical failure after prostate radiation therapy. ( Buyyounouski, MK; Horwitz, EM; Li, T; Zaorsky, NG, 2012)
"The occurrence of metastasis was ascertained monthly by a qualified oncologist, and confirmed, if necessary, by biopsy."1.36Acetyl salicylic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients [corrected]. ( Bhattacharyya, M; Chakraborty, S; Ghosh, R; Girish, GV; Sinha, AK, 2010)
"Ovarian cancer is a gynecological malignancy that is commonly treated by cytoreductive surgery followed by cisplatin treatment."1.33Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. ( Bratasz, A; Ignarro, LJ; Kuppusamy, P; Parinandi, NL; Sridhar, R; Weir, NM; Zweier, JL, 2006)
"Acute in-stent thrombosis is a well-known complication of carotid angioplasty and stenting (CAS) and often due to resistance to or inadequate treatment with platelet-inhibiting agents."1.33Late in-stent thrombosis following carotid angioplasty and stenting. ( Buhk, JH; Knauth, M; Wellmer, A, 2006)
"To prospectively examine the association between non-steroidal anti-inflammatory drugs (NSAIDs) use (including dose and dosage schedule) and the recurrence of colorectal adenomas among individuals who were diagnosed with an adenoma at entry into a clinical trial."1.32Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States). ( Albert, PS; Burt, R; Caan, B; Corle, D; Hasson, M; Iber, F; Kikendall, JW; Lance, P; Lanza, E; Paskett, E; Schatzkin, A; Shike, M; Tangrea, JA; Weissfeld, J; Woodson, K, 2003)
"Treatment of colorectal cancers is based on surgery and the prognosis is determined by the locoregional or metastatic tumor spread."1.30[How I treat colorectal cancer. I. Prevention and adjuvant treatment]. ( Bours, V; Fillet, G; Jerusalem, G, 1998)
"Bronchial asthma was diagnosed in 40% of all patients."1.28Recurrence of nasal polyps after surgical treatment. ( Holopainen, E; Jäntti-Alanko, S; Malmberg, H, 1989)

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-19905 (5.26)18.7374
1990's5 (5.26)18.2507
2000's25 (26.32)29.6817
2010's44 (46.32)24.3611
2020's16 (16.84)2.80

Authors

AuthorsStudies
Yaqub, S1
Bjørnbeth, BA1
Angelsen, JH1
Fristrup, CW1
Grønbech, JE1
Hemmingsson, O1
Isaksson, B1
Juel, IS1
Larsen, PN1
Lindell, G1
Mortensen, FV1
Mortensen, KE1
Rizell, M1
Sandström, P1
Sandvik, OM1
Sparrelid, E1
Taflin, H1
Taskén, K1
Chen, Y2
Zhang, Y1
Chen, S1
Liu, W1
Lin, Y1
Zhang, H2
Yu, F1
Lobo, N1
Hensley, PJ1
Bree, KK1
Nogueras-Gonzalez, GM1
Navai, N1
Dinney, CP1
Kamat, AM1
Kimura, M1
Niwa, JI1
Ito, H1
Matsuyama, K1
Doyu, M1
Wang, A1
Meng, X1
Tian, X1
Zuo, Y1
Bath, PM1
Li, H1
Xie, X1
Jing, J1
Lin, J1
Wang, Y3
Zhao, X1
Liu, L2
Li, Z1
Jiang, Y1
Xu, J1
Wang, F1
Chen, W1
Cao, M1
Li, J1
Jing, P1
Luo, Y1
Tan, J1
Liao, C2
Zhang, S1
Lang, AE1
de Havenon, A1
Mac Grory, B1
Henninger, N1
Shu, L1
Furie, KL1
Easton, JD1
Kim, A1
Johnston, SC1
Yaghi, S1
Miyamoto, K1
Takashima, A1
Mizusawa, J1
Sato, Y3
Shimada, Y1
Katayama, H1
Nakamura, K1
Shibata, T1
Fukuda, H1
Shida, D1
Kanemitsu, Y1
Hamaguchi, T1
McCarthy, AM1
Kumar, NP1
He, W1
Regan, S1
Welch, M1
Moy, B1
Iafrate, AJ1
Chan, AT4
Bardia, A1
Armstrong, K1
Soualy, A1
Deutsch, D1
Benallaoua, M1
Ait-Omar, A1
Mary, F1
Helfen, S1
Boubaya, M1
Levy, V1
Benamouzig, R6
Joshi, SN1
Murphy, EA1
Olaniyi, P1
Bryant, RJ1
Liang, PS1
Shaukat, A1
Crockett, SD2
Ma, S1
Han, T1
Sun, C1
Cheng, C1
Qu, G1
Bhan, C1
Yang, H1
Guo, Z1
Yan, Y1
Cao, C1
Ji, Z1
Zhou, Q1
Saka-Herrán, C1
Jané-Salas, E1
Estrugo-Devesa, A1
López-López, J1
Ishikawa, H2
Mutoh, M2
Doyama, H1
Tajika, M2
Tanaka, S2
Horimatsu, T1
Takeuchi, Y1
Kashida, H1
Tashiro, J1
Ezoe, Y1
Nakajima, T1
Ikematsu, H1
Hori, S1
Suzuki, S2
Otani, T1
Takayama, T2
Ohda, Y1
Mure, K1
Wakabayashi, K2
Sakai, T2
Liu, J2
Zheng, F1
Yang, M1
Wu, X1
Liu, A1
Gash, KJ1
Chambers, AC1
Cotton, DE1
Williams, AC1
Thomas, MG1
Kim, SA1
Roh, JL1
Kim, SB1
Choi, SH1
Nam, SY1
Kim, SY1
Veettil, SK1
Lim, KG1
Ching, SM1
Saokaew, S1
Phisalprapa, P1
Chaiyakunapruk, N1
Cronin-Fenton, D1
Lash, TL2
Ahern, TP2
Damkier, P1
Christiansen, P2
Ejlertsen, B2
Sørensen, HT2
Michel, P1
Boige, V1
Andre, T1
Aparicio, T1
Bachet, JB1
Dahan, L1
Guimbaud, R1
Lepage, C1
Manfredi, S1
Tougeron, D1
Taieb, J1
Selves, J1
Le Malicot, K1
Di Fiore, F1
Maillard, E1
Hawk, E1
Maresso, KC1
Brown, P1
Lyon, TD1
Frank, I1
Shah, PH1
Tarrell, R1
Cheville, JC1
Karnes, RJ1
Thompson, RH1
Tollefson, MK1
Boorjian, SA1
Mohammed, A1
Yarla, NS1
Madka, V1
Rao, CV1
Frisk, G1
Ekberg, S1
Lidbrink, E1
Eloranta, S1
Sund, M1
Fredriksson, I1
Lambe, M1
Smedby, KE1
Khoo, BL1
Grenci, G1
Lim, JSY1
Lim, YP1
Fong, J1
Yeap, WH1
Bin Lim, S1
Chua, SL1
Wong, SC1
Yap, YS1
Lee, SC1
Lim, CT1
Han, J1
Young, SH1
Chau, GY1
Lee, IC1
Yeh, YC1
Chao, Y2
Huo, TI2
Su, CW2
Lin, HC2
Hou, MC1
Lee, MH1
Huang, YH2
Tuyaerts, S1
Van Nuffel, AMT1
Naert, E1
Van Dam, PA1
Vuylsteke, P1
De Caluwé, A1
Aspeslagh, S1
Dirix, P1
Lippens, L1
De Jaeghere, E1
Amant, F1
Vandecasteele, K1
Denys, H1
Lipsky, MJ1
Badalato, GM1
Motamedinia, P1
Hruby, GW1
McKiernan, JM1
Domingo, E1
Church, DN1
Sieber, O1
Ramamoorthy, R1
Yanagisawa, Y1
Johnstone, E1
Davidson, B1
Kerr, DJ1
Tomlinson, IP1
Midgley, R1
Fuchs, CS3
Ogino, S2
Tokudome, S1
Saida, Y1
Abe, T1
Okamura, S1
Joh, T1
Kudo, SE1
Matsuda, T1
Iimuro, M1
Yukawa, T1
Lee, K1
Kitamura, S1
Mizuno, M1
Sano, Y1
Gondo, N1
Sugimoto, K1
Kusunoki, M1
Goto, C1
Matsuura, N1
Kirstein, MM1
Vogel, A1
Soon, SS1
Chia, WK2
Chan, ML1
Ho, GF1
Jian, X1
Deng, YH1
Tan, CS1
Sharma, A1
Segelov, E1
Mehta, S1
Ali, R1
Toh, HC2
Wee, HL1
Ng, K2
Meyerhardt, JA1
Sato, K1
Chan, JA1
Niedzwiecki, D1
Saltz, LB1
Mayer, RJ1
Benson, AB1
Schaefer, PL1
Whittom, R1
Hantel, A1
Goldberg, RM1
Venook, AP1
Giovannucci, EL1
Goh, CH1
Goh, HH1
Leong, WQ1
Chew, MH1
Pan, YS1
Tony, LK1
Chew, L1
Tan, IB1
Tang, CL1
Fu, WP1
Sestak, I1
Cuzick, J1
Harris, K1
Kebbe, J1
Huang, XZ1
Gao, P1
Sun, JX1
Song, YX1
Tsai, CC1
Chen, XW1
Chen, P1
Xu, HM1
Wang, ZN1
Pastore, A1
Palleschi, G1
Fuschi, A1
Silvestri, L1
Al Salhi, Y1
Costantini, E1
Zucchi, A1
Petrozza, V1
de Nunzio, C1
Carbone, A1
Lee, M1
Gibbs, P1
Fedirko, V1
Bradshaw, PT1
Figueiredo, JC2
Sandler, RS4
Barry, EL4
Ahnen, DJ3
Milne, GL1
Bresalier, RS2
Baron, JA8
Leonard, JP1
Jung, SH1
Johnson, J1
Pitcher, BN1
Bartlett, NL1
Blum, KA1
Czuczman, M1
Giguere, JK1
Cheson, BD1
Pommergaard, HC1
Burcharth, J1
Rosenberg, J1
Raskov, H1
McNamara, MG1
Aneja, P1
Le, LW1
Horgan, AM1
McKeever, E1
Knox, JJ1
Cronin-Fenton, DP1
Heide-Jørgensen, U1
Zhao, TY1
Tu, J1
Cheng, DW1
Gao, XK1
Luo, H1
Yan, BC1
Xu, XL1
Zhang, HL1
Lu, XJ1
Wang, YJ1
Lee, PC1
Yeh, CM1
Hu, YW1
Chen, CC1
Liu, CJ1
Chen, TJ1
Wu, JC1
Burn, J1
Sheth, H1
Coyle, C1
Cafferty, FH1
Rowley, S1
MacKenzie, M1
Berkman, L1
Gupta, S1
Pramesh, CS1
Gilbert, D1
Kynaston, H1
Cameron, D1
Wilson, RH1
Ring, A1
Langley, RE1
Veeraputhiran, M1
Sundermeyer, M1
Levine, AJ3
Grau, MV3
Midttun, O1
Ueland, PM3
Tsang, S3
Munroe, D1
Ali, I1
Haile, RW2
Wallace, K1
Saibil, F2
Ahnen, D1
Cole, BF2
Munroe, DJ2
Ali, IU2
Ueland, P1
Gee, JR1
Jarrard, DF1
Bruskewitz, RC1
Moon, TD1
Hedican, SP1
Leverson, GE1
Nakada, SY1
Messing, EM1
Gao, F1
Tan, A1
Cao, Y1
Mo, Z1
Logan, RF5
Halabi, S1
Grainge, MJ4
Chaussade, S5
Sansbury, LB1
Gui, J1
McKeown-Eyssen, GE1
Burke, C1
Hazra, A1
Selhub, J1
Chao, WH1
Hunter, DJ1
Uzzan, B2
Martin, A3
Deyra, J3
Little, J4
Girard, B2
Bhattacharyya, M1
Girish, GV1
Ghosh, R1
Chakraborty, S1
Sinha, AK1
Mott, LA1
Arber, N1
Spicak, J1
Rácz, I1
Zavoral, M1
Breazna, A1
Gerletti, P1
Lechuga, MJ1
Collins, N1
Rosenstein, RB1
Eagle, CJ1
Levin, B1
Zaorsky, NG1
Buyyounouski, MK1
Li, T1
Horwitz, EM1
McCowan, C1
Munro, AJ1
Donnan, PT1
Steele, RJ1
Jullian, E1
Piednoir, B1
Couturier, D2
Coste, T2
Tangrea, JA1
Albert, PS1
Lanza, E2
Woodson, K1
Corle, D1
Hasson, M1
Burt, R1
Caan, B1
Paskett, E1
Iber, F1
Kikendall, JW2
Lance, P2
Shike, M2
Weissfeld, J1
Schatzkin, A2
RAMSAY, AG1
WHITE, DF1
Turris, SA1
Smith, S1
Salman, MC1
Ayhan, A1
Bratasz, A1
Weir, NM1
Parinandi, NL1
Zweier, JL1
Sridhar, R1
Ignarro, LJ1
Kuppusamy, P1
Buhk, JH1
Wellmer, A1
Knauth, M1
Hubner, RA3
Muir, KR4
Liu, JF3
Grainge, M1
Armitage, N1
Shepherd, V1
Popat, S1
Houlston, RS3
Topakian, R1
Nussbaumer, K1
Trenkler, J1
Aichner, FT1
Flossmann, E1
Rothwell, PM1
Shepherd, VC1
Armitage, NC1
Lundberg, GD1
Drake-Lee, AB1
Lowe, D1
Swanston, A1
Grace, A1
Enzmann, H1
Rieben, FW1
van Camp, C1
Clement, PA2
Olivotto, IA1
Weir, LM1
Kim-Sing, C1
Bajdik, CD1
Trevisan, CH1
Doll, CM1
Lam, WY1
Basco, VE1
Jackson, SM1
Freedman, LS1
Tangrea, J1
Cooper, MR1
Marshall, JR1
Murphy, PA1
Selby, JV1
Schade, RR1
Burt, RW1
Cahill, J1
Bours, V1
Jerusalem, G1
Fillet, G1
Schmid, M1
Göde, U1
Schäfer, D1
Wigand, ME1
Amar, YG1
Frenkiel, S1
Sobol, SE1
Di Rienzo, L1
Artuso, A1
Cerqua, N1
Yoon, H1
van der Veken, P1
Verstraelen, J1
Buisseret, T1
Cox, A1
Frécourt, N1
Kaufman, L1
Derde, MP1
Jäntti-Alanko, S1
Holopainen, E1
Malmberg, H1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acetylsalicylic Acid as Secondary Prevention in Colorectal Cancer[NCT03326791]Phase 2/Phase 3466 participants (Actual)Interventional2017-12-15Active, not recruiting
Assessment of the Effect of a Daily Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome[NCT02813824]Phase 3852 participants (Anticipated)Interventional2017-11-14Recruiting
A Phase II Investigation of Pembrolizumab (Keytruda) in Combination With Radiation and an Immune Modulatory Cocktail in Patients With Cervical and Uterine Cancer (PRIMMO Trial)[NCT03192059]Phase 243 participants (Actual)Interventional2017-07-01Completed
A Randomized Phase II Trial of Rituximab Versus Lenalidomide (REVLIMID™, Cc-5013) (IND#73034) Versus Rituximab + Lenalidomide in Recurrent Follicular Non-Hodgkin Lymphoma (NHL) That is Not Rituximab-Refractory[NCT00238238]Phase 297 participants (Actual)Interventional2006-03-31Completed
Phase Ib Dose Finding Study of Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib (PCI-32765) Plus Lenalidomide / Rituximab in Relapsed or Refractory Mantle Cell Lymphoma (MCL)[NCT02446236]Phase 127 participants (Actual)Interventional2015-06-18Active, not recruiting
A Clinical Trial Evaluating the Efficacy and Safety of a Combination Treatment Administered Over 3 Years in Patients at Risk of Experiencing Recurrence of Colorectal Adenomas[NCT00486512]Phase 3350 participants (Actual)Interventional2007-06-30Terminated (stopped due to The overall program was terminated)
Aspirin/Folate Prevention of Large Bowel Polyps[NCT00272324]Phase 2/Phase 31,121 participants Interventional1992-02-29Completed
Clinical Protocol For a Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Celecoxib (SC-58635) In The Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP)[NCT00141193]Phase 31,561 participants (Actual)Interventional2001-02-28Completed
Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence[NCT00224679]Phase 3300 participants Interventional1997-03-31Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Response Rate

Response is assessed by investigator according to International Working Group (IWG) criteria. A complete response requires disappearance of all evidence of disease. A partial response is a >/= 50% decrease in the sum of products of 6 largest dominant nodes or nodal masses as well as for splenic and hepatic nodules. No increase in size of nodes, liver or spleen and no new sites of disease. (NCT00238238)
Timeframe: Duration of treatment (12 cycles)

Interventionpercentage of participants (Number)
Arm II - Lenalidomide53.3
Arm III - Lenalidomide and Rituximab76.1

Time to Progression

Time to progression (TTP) is defined as the time from study entry until progression or death without progression. The median TTP with 95% CI was estimated using the Kaplan-Meier method. (NCT00238238)
Timeframe: Up to 10 years

Interventionyears (Median)
Arm II - Lenalidomide1.1
Arm III - Lenalidomide and Rituximab2

Reviews

17 reviews available for aspirin and Local Neoplasm Recurrence

ArticleYear
The multiple effects of aspirin in prostate cancer patients.
    Cancer treatment and research communications, 2021, Volume: 26

    Topics: Aspirin; Chemoradiotherapy; Chemotherapy, Adjuvant; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; D

2021
AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia: Expert Review.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2021, Volume: 19, Issue:7

    Topics: Aspirin; Chemoprevention; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Humans; Neoplasm Recurren

2021
Does aspirin reduce the incidence, recurrence, and mortality of colorectal cancer? A meta-analysis of randomized clinical trials.
    International journal of colorectal disease, 2021, Volume: 36, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Humans; Incidence; Neoplasm

2021
Head and neck cancer and non-steroidal anti-inflammatory drugs: Systematic review and meta-analysis.
    Head & neck, 2021, Volume: 43, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Head and Neck Neoplasms; Humans; Neoplasm Recurren

2021
Effect of aspirin use on survival benefits of breast cancer patients: A meta-analysis.
    Medicine, 2021, Aug-20, Volume: 100, Issue:33

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Female; Humans; Neoplasm Recurre

2021
Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy.
    British journal of cancer, 2017, Jul-11, Volume: 117, Issue:2

    Topics: Aspirin; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Humans; H

2017
Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials.
    BMC cancer, 2017, Nov-14, Volume: 17, Issue:1

    Topics: Adenoma; Anti-Inflammatory Agents; Aspirin; Colorectal Neoplasms; Humans; Incidence; Neoplasm Recurr

2017
Clinically Relevant Anti-Inflammatory Agents for Chemoprevention of Colorectal Cancer: New Perspectives.
    International journal of molecular sciences, 2018, Aug-08, Volume: 19, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Ce

2018
Update on breast cancer risk prediction and prevention.
    Current opinion in obstetrics & gynecology, 2015, Volume: 27, Issue:1

    Topics: Age of Onset; Aromatase Inhibitors; Aspirin; Biomarkers, Tumor; Breast Neoplasms; Diphosphonates; Fe

2015
Aspirin and nonsteroidal anti-inflammatory drugs after but not before diagnosis are associated with improved breast cancer survival: a meta-analysis.
    Cancer causes & control : CCC, 2015, Volume: 26, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Female; Humans; Neoplasm Recurre

2015
The Efficacy of Aspirin in Preventing the Recurrence of Colorectal Adenoma: a Renewed Meta-Analysis of Randomized Trials.
    Asian Pacific journal of cancer prevention : APJCP, 2016, Volume: 17, Issue:5

    Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Humans; Neoplasm Re

2016
The role of aspirin in preventing colorectal cancer.
    British medical bulletin, 2016, Volume: 119, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Gastrointestinal Hemorrhage;

2016
The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2009, Volume: 11, Issue:9

    Topics: Adenoma; Aspirin; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Humans; Neoplasm Recurrence, Loca

2009
Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.
    Journal of the National Cancer Institute, 2009, Feb-18, Volume: 101, Issue:4

    Topics: Adenoma; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colorectal

2009
What every emergency nurse needs to know about aspirin.
    Accident and emergency nursing, 2005, Volume: 13, Issue:2

    Topics: Aspirin; Colorectal Neoplasms; Coronary Disease; Delayed-Action Preparations; Drug Administration Sc

2005
Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer.
    Current topics in medicinal chemistry, 2005, Volume: 5, Issue:5

    Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Case-Co

2005
Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies.
    Lancet (London, England), 2007, May-12, Volume: 369, Issue:9573

    Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Colorectal

2007

Trials

25 trials available for aspirin and Local Neoplasm Recurrence

ArticleYear
Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial.
    Trials, 2021, Sep-20, Volume: 22, Issue:1

    Topics: Aspirin; Colorectal Neoplasms; Double-Blind Method; Humans; Liver Neoplasms; Multicenter Studies as

2021
Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial.
    European stroke journal, 2023, Volume: 8, Issue:1

    Topics: Aspirin; Clopidogrel; Hemorrhage; Humans; Ischemic Attack, Transient; Ischemic Stroke; Neoplasm Recu

2023
Efficacy of aspirin for stage III colorectal cancer: a randomized double-blind placebo-controlled trial (JCOG1503C, EPISODE-III trial).
    Japanese journal of clinical oncology, 2019, Oct-01, Volume: 49, Issue:10

    Topics: Adult; Aged; Aspirin; Colorectal Neoplasms; Double-Blind Method; Female; Follow-Up Studies; Humans;

2019
Effect of chemoprevention by low-dose aspirin of new or recurrent colorectal adenomas in patients with Lynch syndrome (AAS-Lynch): study protocol for a multicenter, double-blind, placebo-controlled randomized controlled trial.
    Trials, 2020, Sep-04, Volume: 21, Issue:1

    Topics: Adenoma; Adult; Aspirin; Chemoprevention; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Non

2020
Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial.
    The lancet. Gastroenterology & hepatology, 2021, Volume: 6, Issue:6

    Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control St

2021
Aspirin versus placebo in stage III or high-risk stage II colon cancer with PIK3CA mutation: A French randomised double-blind phase III trial (PRODIGE 50-ASPIK).
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2018, Volume: 50, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aspirin; Class I Phosphatidylinositol 3-Kinases; Col

2018
PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer.
    BMC cancer, 2019, May-28, Volume: 19, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Aspirin; Chemoradiotherapy; Curcumin; Cycl

2019
Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Dec-01, Volume: 31, Issue:34

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotherapy, Adju

2013
The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial.
    Gut, 2014, Volume: 63, Issue:11

    Topics: Adenocarcinoma; Adenoma; Adult; Aged; Alcohol Drinking; Anticarcinogenic Agents; Aspirin; Colonic Ne

2014
Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS).
    Cancer prevention research (Philadelphia, Pa.), 2015, Volume: 8, Issue:11

    Topics: Adenoma; Administration, Oral; Aged; Aspirin; Chromatography, Gas; Chromatography, Liquid; Colonosco

2015
Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Disease Pro

2015
Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Disease Pro

2015
Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Disease Pro

2015
Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Disease Pro

2015
Aspirin, Calcitriol, and Calcium Do Not Prevent Adenoma Recurrence in a Randomized Controlled Trial.
    Gastroenterology, 2016, Volume: 150, Issue:1

    Topics: Adenoma; Adult; Aged; Aspirin; Calcitriol; Calcium; Chemoprevention; Colectomy; Colorectal Neoplasms

2016
ADD-ASPIRIN: A phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.
    Contemporary clinical trials, 2016, Volume: 51

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Chemotherapy, Adjuvant; Colorect

2016
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:8

    Topics: Adenoma; Alcohol Drinking; Aspirin; Chemoprevention; Colorectal Neoplasms; Double-Blind Method; Fema

2008
MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:9

    Topics: Adenoma; Alleles; Aspirin; Chi-Square Distribution; Colorectal Neoplasms; Double-Blind Method; Femal

2008
Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009, Volume: 18, Issue:10

    Topics: Adenoma; Aged; Aspirin; Cohort Studies; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inh

2009
Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention.
    Gut, 2010, Volume: 59, Issue:5

    Topics: Adenoma; Adolescent; Adult; Aged; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Colorectal Ne

2010
Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:10

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Aspirin; Colorectal Neoplasms; Double-Blind Method; Folic A

2010
Five-year analysis of the prevention of colorectal sporadic adenomatous polyps trial.
    The American journal of gastroenterology, 2011, Volume: 106, Issue:6

    Topics: Adenomatous Polyposis Coli; Administration, Oral; Age Factors; Aged; Aged, 80 and over; Aspirin; Col

2011
Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial.
    Gastroenterology, 2003, Volume: 125, Issue:2

    Topics: Adenoma; Aspirin; Colorectal Neoplasms; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neopla

2003
Genetic variants of UGT1A6 influence risk of colorectal adenoma recurrence.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Nov-01, Volume: 12, Issue:21

    Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Female; Genetic Pre

2006
Aspirin and folic acid for the prevention of recurrent colorectal adenomas.
    Gastroenterology, 2008, Volume: 134, Issue:1

    Topics: Adenoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotherapy, Adjuvant; Colo

2008
Late cosmetic results of short fractionation for breast conservation.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1996, Volume: 41, Issue:1

    Topics: Aspirin; Breast; Breast Neoplasms; Female; Follow-Up Studies; Humans; Mastectomy, Segmental; Middle

1996
The polyp prevention trial I: rationale, design, recruitment, and baseline participant characteristics.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:5

    Topics: Adenoma; Adenomatous Polyps; Adult; Aspirin; Colonic Neoplasms; Colonic Polyps; Colonoscopy; Demogra

1996
APACC, a French prospective study on aspirin efficacy in reducing colorectal adenoma recurrence: design and baseline findings.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2001, Volume: 10, Issue:4

    Topics: Adenoma; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colono

2001

Other Studies

53 other studies available for aspirin and Local Neoplasm Recurrence

ArticleYear
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL.
    Pigment cell & melanoma research, 2022, Volume: 35, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Humans; Melanoma; Mitogen-Activa

2022
Should patients with non-muscle-invasive bladder cancer discontinue fibrin clot inhibitors during bacille Calmette-Guérin?
    BJU international, 2022, Volume: 130, Issue:4

    Topics: Adjuvants, Immunologic; Administration, Intravesical; Anticoagulants; Aspirin; BCG Vaccine; Clopidog

2022
Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report.
    BMC neurology, 2022, Oct-22, Volume: 22, Issue:1

    Topics: Anti-Bacterial Agents; Aspirin; Calcinosis; Calcium; Cerebral Infarction; Female; Fibrin; Fibrinolyt

2022
Ticagrelor Aspirin vs Clopidogrel Aspirin in
    Neurology, 2023, 01-31, Volume: 100, Issue:5

    Topics: Aspirin; Cerebral Infarction; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Huma

2023
Aspirin-Loaded Cross-Linked Lipoic Acid Nanodrug Prevents Postoperative Tumor Recurrence by Residual Cancer Cell Killing and Inflammatory Microenvironment Improvement.
    Bioconjugate chemistry, 2023, 02-15, Volume: 34, Issue:2

    Topics: Antineoplastic Agents; Aspirin; Cell Death; Cell Line, Tumor; Cisplatin; Humans; Nanoparticles; Neop

2023
Different associations of tumor PIK3CA mutations and clinical outcomes according to aspirin use among women with metastatic hormone receptor positive breast cancer.
    BMC cancer, 2020, Apr-23, Volume: 20, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspi

2020
Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up.
    International journal of clinical oncology, 2018, Volume: 23, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Squamou

2018
Concurrent new drug prescriptions and prognosis of early breast cancer: studies using the Danish Breast Cancer Group clinical database.
    Acta oncologica (Stockholm, Sweden), 2018, Volume: 57, Issue:1

    Topics: Adrenergic beta-Antagonists; Analgesics, Opioid; Angiotensin-Converting Enzyme Inhibitors; Anti-Infl

2018
NSAIDs to Prevent Breast Cancer Recurrence? An Unanswered Question.
    Journal of the National Cancer Institute, 2018, 09-01, Volume: 110, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aromatase Inhibitors; Aspirin; Breast Neoplasms; Celecoxib;

2018
The Association of Aspirin Use with Survival Following Radical Cystectomy.
    The Journal of urology, 2018, Volume: 200, Issue:5

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cystectomy; Disease-Free Survival; Female; F

2018
No association between low-dose aspirin use and breast cancer outcomes overall: a Swedish population-based study.
    Breast cancer research : BCR, 2018, 11-20, Volume: 20, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms;

2018
Low-dose anti-inflammatory combinatorial therapy reduced cancer stem cell formation in patient-derived preclinical models for tumour relapse prevention.
    British journal of cancer, 2019, Volume: 120, Issue:4

    Topics: Anti-Inflammatory Agents; Apoptosis; Aspirin; Cell Line, Tumor; Doxorubicin; Drug Therapy, Combinati

2019
Aspirin is associated with low recurrent risk in hepatitis B virus-related hepatocellular carcinoma patients after curative resection.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2020, Volume: 119, Issue:1 Pt 2

    Topics: Aged; alpha-Fetoproteins; Antiviral Agents; Aspirin; Carcinoma, Hepatocellular; Female; Hepatectomy;

2020
The effect of fibrin clot inhibitors on the immunomodulatory efficacy of Bacillus Calmette-Guérin therapy for non-muscle-invasive bladder cancer.
    Urology, 2013, Volume: 81, Issue:6

    Topics: Adjuvants, Immunologic; Aged; Aged, 80 and over; Anticoagulants; Aspirin; BCG Vaccine; Clopidogrel;

2013
Aspirin therapy for colorectal cancer with PIK3CA mutation: simply complex!
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Dec-01, Volume: 31, Issue:34

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Class I Phosphatidylinositol 3-Kinases; Colorectal

2013
[Aspirin and PIK3CA mutation in colorectal cancer].
    Zeitschrift fur Gastroenterologie, 2014, Volume: 52, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Female; Humans; Lactones; Ma

2014
Cost-effectiveness of aspirin adjuvant therapy in early stage colorectal cancer in older patients.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Aspirin; Capecitabin

2014
Aspirin and COX-2 inhibitor use in patients with stage III colon cancer.
    Journal of the National Cancer Institute, 2015, Volume: 107, Issue:1

    Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemother

2015
Post-operative aspirin use and colorectal cancer-specific survival in patients with stage I-III colorectal cancer.
    Anticancer research, 2014, Volume: 34, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Asian People; Aspirin; Colorectal Neoplasms; Disease-Free Survival;

2014
Endobronchial biopsies on aspirin and prasugrel.
    Heart, lung & circulation, 2015, Volume: 24, Issue:6

    Topics: Angioplasty, Balloon, Coronary; Aspirin; Biopsy, Needle; Bronchoscopy; Carcinoma, Squamous Cell; Cor

2015
Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection.
    BMC cancer, 2015, Mar-13, Volume: 15

    Topics: Aspirin; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Neoplasm

2015
RE: Aspirin and COX-2 Inhibitor Use in Patients With Stage III Colon Cancer.
    Journal of the National Cancer Institute, 2015, Volume: 107, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Co

2015
Response.
    Journal of the National Cancer Institute, 2015, Volume: 107, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Co

2015
A Chemopreventive Cocktail on the Rocks.
    Gastroenterology, 2016, Volume: 150, Issue:1

    Topics: Aspirin; Calcitriol; Calcium; Female; Humans; Male; Neoplasm Recurrence, Local; Secondary Prevention

2016
Effects of Statin, Aspirin or Metformin Use on Recurrence-Free and Overall Survival in Patients with Biliary Tract Cancer.
    Hepato-gastroenterology, 2015, Volume: 62, Issue:139

    Topics: Aged; Aspirin; Biliary Tract Neoplasms; Cardiovascular Agents; Comorbidity; Disease Progression; Dis

2015
Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence.
    Epidemiology (Cambridge, Mass.), 2016, Volume: 27, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms;

2016
Antiplatelet Therapy is Associated with a Better Prognosis for Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma after Liver Resection.
    Annals of surgical oncology, 2016, Volume: 23, Issue:Suppl 5

    Topics: Adult; Aged; Aspirin; Carcinoma, Hepatocellular; Clopidogrel; Disease-Free Survival; Female; Gastroi

2016
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
    Clinical lung cancer, 2008, Volume: 9, Issue:4

    Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensiv

2008
Reduced bladder cancer recurrence rate with cardioprotective aspirin after intravesical bacille Calmette-Guérin.
    BJU international, 2009, Volume: 103, Issue:6

    Topics: Administration, Intravesical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents;

2009
Uracil misincorporation into DNA and folic acid supplementation.
    The American journal of clinical nutrition, 2010, Volume: 91, Issue:1

    Topics: Adenoma; Aged; Alcohol Drinking; Aspirin; Colonoscopy; Colorectal Neoplasms; Dietary Supplements; DN

2010
COX-2 expression in adenoma: an imperfect marker for chemoprevention.
    Gut, 2010, Volume: 59, Issue:5

    Topics: Adenoma; Anticarcinogenic Agents; Aspirin; Biomarkers, Tumor; Colorectal Neoplasms; Cyclooxygenase 2

2010
Acetyl salicylic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients [corrected].
    Cancer science, 2010, Volume: 101, Issue:10

    Topics: Adult; Aged; Aspirin; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm R

2010
Aspirin and statin nonuse associated with early biochemical failure after prostate radiation therapy.
    International journal of radiation oncology, biology, physics, 2012, Sep-01, Volume: 84, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticoagulants; Antineoplastic

2012
Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma; Cause o

2013
Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States).
    Cancer causes & control : CCC, 2003, Volume: 14, Issue:5

    Topics: Adenoma; Adenomatous Polyps; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; As

2003
PHENACETIN NEPHROPATHY.
    Canadian Medical Association journal, 1965, Jan-09, Volume: 92

    Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy

1965
Use of anti-thrombotic agents during chemotherapy for epithelial ovarian cancer.
    Medical hypotheses, 2006, Volume: 66, Issue:6

    Topics: Antineoplastic Agents; Aspirin; Drug Combinations; Female; Fibrinolytic Agents; Humans; Neoplasm Rec

2006
Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Mar-07, Volume: 103, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Cell Proliferation; Cisplatin; D

2006
Late in-stent thrombosis following carotid angioplasty and stenting.
    Neurology, 2006, May-23, Volume: 66, Issue:10

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aph

2006
Late in-stent thrombosis following carotid angioplasty and stenting.
    Neurology, 2007, Jan-30, Volume: 68, Issue:5

    Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aph

2007
Chemoprevention for colorectal cancer: some progress but a long way to go.
    Gastroenterology, 2008, Volume: 134, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Folic Acid; Hematinics; Huma

2008
Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Apr-15, Volume: 14, Issue:8

    Topics: Adenoma; Adult; Aged; Anticarcinogenic Agents; Aspirin; Colorectal Neoplasms; Female; Genes, APC; Ge

2008
Aspirin helps prevent recurring colorectal adenomas--folic acid does not.
    Medscape journal of medicine, 2008, Mar-20, Volume: 10, Issue:3

    Topics: Adenoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotherapy, Adjuvant; Colo

2008
Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence.
    International journal of cancer, 2008, Aug-01, Volume: 123, Issue:3

    Topics: Adenoma; Adult; Aged; Animals; Aspirin; Calcium Compounds; Colorectal Neoplasms; Dairy Products; Fem

2008
Clinical profile and recurrence of nasal polyps.
    The Journal of laryngology and otology, 1984, Volume: 98, Issue:8

    Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Eczema; Female; Humans; Male; Middl

1984
[Rhinosinusitis polyposa and intolerance to analgesics (aspirin intolerance)].
    Laryngologie, Rhinologie, Otologie, 1983, Volume: 62, Issue:3

    Topics: Adult; Aged; Analgesics; Aspirin; Bronchial Provocation Tests; Drug Hypersensitivity; Drug Tolerance

1983
Results of oral steroid treatment in nasal polyposis.
    Rhinology, 1994, Volume: 32, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aspirin; Combined Modality Therapy; Drug Hypersensitivity; Female

1994
[How I treat colorectal cancer. I. Prevention and adjuvant treatment].
    Revue medicale de Liege, 1998, Volume: 53, Issue:4

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Antimeta

1998
Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics.
    Acta oto-laryngologica, 1999, Volume: 119, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Bronchial Provoca

1999
Outcome analysis of endoscopic sinus surgery for chronic sinusitis in patients having Samter's triad.
    The Journal of otolaryngology, 2000, Volume: 29, Issue:1

    Topics: Adult; Age of Onset; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Chronic Disease

2000
[Antileukotrienes in the prevention of postoperative recurrence of nasal polyposis in ASA syndrome].
    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2000, Volume: 20, Issue:5

    Topics: Acetates; Adult; Aged; Aspirin; Asthma; Cyclopropanes; Drug Hypersensitivity; Female; Humans; Leukot

2000
Recurrent polyposis nasi. Documentation.
    Rhinology. Supplement, 1989, Volume: 8

    Topics: Adult; Aged; Airway Resistance; Aspirin; Female; Humans; Male; Middle Aged; Nasal Polyps; Nasal Prov

1989
Recurrence of nasal polyps after surgical treatment.
    Rhinology. Supplement, 1989, Volume: 8

    Topics: Adrenal Cortex Hormones; Aspirin; Asthma; Drug Hypersensitivity; Ethmoid Sinus; Follow-Up Studies; H

1989
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