aspirin has been researched along with Liver Failure, Acute in 5 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, some patients may develop acute liver failure and successful orthotopic liver transplantation may be undertaken in such patients." | 2.42 | Hepatocellular damage from non-steroidal anti-inflammatory drugs. ( Dargan, PI; Jones, AL; O'Connor, N, 2003) |
| "We provided optimal treatment of severe hyperammonemia (>500 µmol/L) and cerebral edema, including high doses of arginine chloride, sodium benzoate, hemodialysis, mild hypothermia, and supportive care." | 1.62 | Reye Syndrome with Severe Hyperammonemia and a Good Neurological Outcome. ( Battelino, T; Bratina, N; Groselj, U; Herga, P; Klemenčič, S; Osredkar, D; Pribožič, L; Rajtar Osredkar, S; Repič Lampret, B; Vidmar, I; Žerjav Tanšek, M, 2021) |
| "Acute liver failure was associated with increased risk for major complications (odds ratio 26." | 1.38 | Evaluation of risk factors for bleeding after liver biopsy in children. ( Aagenæs, I; Almaas, R; Sanengen, T; Westheim, BH; Østensen, AB, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pribožič, L | 1 |
| Žerjav Tanšek, M | 1 |
| Herga, P | 1 |
| Osredkar, D | 1 |
| Rajtar Osredkar, S | 1 |
| Vidmar, I | 1 |
| Repič Lampret, B | 1 |
| Klemenčič, S | 1 |
| Bratina, N | 1 |
| Battelino, T | 1 |
| Groselj, U | 1 |
| Dinakaran, D | 1 |
| Sergi, CM | 1 |
| Shirota, T | 1 |
| Ikegami, T | 1 |
| Sugiyama, S | 1 |
| Kubota, K | 1 |
| Shimizu, A | 1 |
| Ohno, Y | 1 |
| Mita, A | 1 |
| Urata, K | 1 |
| Nakazawa, Y | 1 |
| Kobayashi, A | 1 |
| Iwaya, M | 1 |
| Miyagawa, S | 1 |
| Westheim, BH | 1 |
| Østensen, AB | 1 |
| Aagenæs, I | 1 |
| Sanengen, T | 1 |
| Almaas, R | 1 |
| O'Connor, N | 1 |
| Dargan, PI | 1 |
| Jones, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Childhood Liver Disease Research Network (ChiLDReN): FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE) Study Protocol[NCT02922751] | 552 participants (Actual) | Observational | 2016-11-16 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aspirin and Liver Failure, Acute
| Article | Year |
|---|---|
Co-ingestion of aspirin and acetaminophen promoting fulminant liver failure: A critical review of Reye syndrome in the current perspective at the dawn of the 21st century.
Topics: Acetaminophen; Aspirin; Child; Drug Interactions; Drug Therapy, Combination; Humans; Liver Failure, | 2018 |
Hepatocellular damage from non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Injury; D | 2003 |
3 other studies available for aspirin and Liver Failure, Acute
| Article | Year |
|---|---|
Reye Syndrome with Severe Hyperammonemia and a Good Neurological Outcome.
Topics: Aspirin; Brain Edema; Child, Preschool; Humans; Hyperammonemia; Liver Failure, Acute; Male; Reye Syn | 2021 |
Successful living donor liver transplantation for acute liver failure after acetylsalicylic acid overdose.
Topics: Acute Disease; Acute Kidney Injury; Aspirin; Drug Overdose; Female; Hepatic Encephalopathy; Humans; | 2015 |
Evaluation of risk factors for bleeding after liver biopsy in children.
Topics: Adolescent; Aspirin; Biopsy; Blood Coagulation Disorders; Child; Child, Preschool; Confidence Interv | 2012 |