Page last updated: 2024-10-23

aspirin and Leg Ulcer

aspirin has been researched along with Leg Ulcer in 25 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to determine the effect of low-dose aspirin on venous leg ulcer healing when used in addition to compression."9.22Low-dose aspirin as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU). ( Bullen, C; Jull, A; Kerse, N; Parag, V; Wadham, A; Waters, J, 2016)
"Four patients with livedo vasculitis were started on a regimen of beraprost sodium (120 micrograms daily)."9.08Successful treatment of livedo vasculitis with beraprost sodium: a possible mechanism of thrombomodulin upregulation. ( Shirasaki, F; Takata, M; Takehara, K; Tsutsui, K, 1996)
"The aim of this study was to determine the effect of low-dose aspirin on venous leg ulcer healing when used in addition to compression."5.22Low-dose aspirin as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU). ( Bullen, C; Jull, A; Kerse, N; Parag, V; Wadham, A; Waters, J, 2016)
"Four patients with livedo vasculitis were started on a regimen of beraprost sodium (120 micrograms daily)."5.08Successful treatment of livedo vasculitis with beraprost sodium: a possible mechanism of thrombomodulin upregulation. ( Shirasaki, F; Takata, M; Takehara, K; Tsutsui, K, 1996)
" We conducted 31 semi-structured telephone interviews of patients who participated in the Aspirin in Venous Leg Ulcer (ASPiVLU) randomised controlled trail (RCT) or ASPiVLU cohort study."3.96Rationale for participation in venous leg ulcer clinical research: Patient interview study. ( Richards, C; Team, V; Turnour, L; Weller, CD, 2020)
"Genetically, Klinefelter's syndrome is characterized by a super-numerary chromosome X in male subjects presenting with clinical and biochemical hypoandrogenism and relative hyperoestrogenism."2.38[Klinefelter's syndrome and leg ulcers: role of blood coagulation disorders]. ( Berbis, P; Bonerandi, JJ; Hesse, S; Juhan-Vague, I; Privat, Y, 1992)
"However, in sickle cell anemia, does the obligate period of flap ischemia inherent in free-tissue transfer inevitably doom a flap to failure? We present our multidisciplinary experience over 55 months with five free flaps in four homozygous sickle cell anemia patients 21 to 38 years old who had chronic nonhealing leg ulcerations."1.29Lower limb salvage by microvascular free-tissue transfer in patients with homozygous sickle cell disease. ( Koshy, M; Marschall, M; Schuler, J; Weinzweig, N, 1995)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.00)18.7374
1990's8 (32.00)18.2507
2000's3 (12.00)29.6817
2010's7 (28.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Weller, CD1
Richards, C1
Turnour, L1
Team, V1
Razmi T, M1
Jindal, AK1
Arora, K1
Joshi, V1
Suri, D1
De, D1
Jull, A2
Wadham, A2
Bullen, C2
Parag, V2
Kerse, N2
Waters, J2
Criado, PR1
Alavi, A1
Halpern, I1
Sotto, MN1
Kirsner, RS1
Castillo-Martínez, C1
Moncada, B1
Valdés-Rodríguez, R1
González, FJ1
Lewerenz, V1
Burchardt, T1
Büchau, A1
Ruzicka, T1
Megahed, M1
Barlas, S1
Tansel, T1
Reilly, JT1
Weinzweig, N1
Schuler, J1
Marschall, M1
Koshy, M1
Newton, W1
Bühler-Singer, S1
von Hintzenstern, J1
Fartasch, M1
Hornstein, OP1
Tsutsui, K1
Shirasaki, F1
Takata, M1
Takehara, K1
Goodfield, M1
Walker, M1
Hulme, TA1
Rippon, MG1
Walmsley, RS1
Gunnigle, S1
Lewin, M1
Winsey, S1
Hafner, J1
Hesse, S1
Berbis, P1
Juhan-Vague, I1
Bonerandi, JJ1
Privat, Y1
Heng, MC1
Song, MK1
Heng, MK1
Grossman, JA1
Barrall, DT1
Dennison, A1
Lally, EV1
Huntsman, RG1
Lehmann, H1
van der Molen, HR1
Töth, LM1
Galambos, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Low Dose Aspirin for Venous Leg Ulcers: a Randomised Trial[NCT02158806]Phase 3251 participants (Actual)Interventional2015-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Estimated Ulcer Area

Change in estimated ulcer area from baseline to 24 weeks (NCT02158806)
Timeframe: Baseline, 24 weeks

Interventionsquare centimetres (Mean)
Aspirin4.1
Placebo4.8

Change in Health-related Quality of Life (EuroQol-5D 3L)

Mean difference in change measured by EuroQol 5D (EQ5D 3L) from baseline to 24 weeks. Crude health state scores for each group are not shown (health state is scored 0 to 100 at baseline and 24 weeks); higher mean differences in change from baseline to 24 weeks within groups indicate greater change on health state for that group. (NCT02158806)
Timeframe: Baseline, 24 weeks

Interventionscore on a scale (Mean)
Aspirin7.4
Placebo4.0

Number of Participants With Adherence to Treatment

Adherence to study medication as measured by pill counts (agreement between expected number of tablets remaining after healing and days to healing) (NCT02158806)
Timeframe: 24 weeks

InterventionParticipants (Count of Participants)
Aspirin92
Placebo92

Number of Participants With Healed Venous Leg Ulcers

Number of participants in each arm with completely healed reference ulcers at 24 weeks (NCT02158806)
Timeframe: 24 weeks

InterventionParticipants (Count of Participants)
Aspirin88
Placebo101

Time to Complete Healing of Reference Ulcer

Time to event (complete healing defined as intact skin with absence of scab) (NCT02158806)
Timeframe: 24 weeks

Interventiondays (Median)
Aspirin77
Placebo69

Change in Health-related Quality of Life (Charing Cross Venous Ulcer Questionnaire)

Mean difference in change in Charing Cross Venous Ulcer Questionnaire (CXVUQ)) from baseline to 24 weeks. Crude subscale scores for each group are not shown (each crude subscale is scored 0 to 100 at baseline and 24 weeks); higher mean differences in change from baseline to 24 weeks within groups indicate greater change on the subscales for that group. (NCT02158806)
Timeframe: 24 weeks

,
Interventionscore on a scale (Mean)
Social functionDomestic activitiesCosmesisEmotional statusOverall
Aspirin-6.2-6.6-6.1-9.4-7.3
Placebo-4.7-5.2-4.9-6.5-5.5

Change in Health-related Quality of Life (Short Form 36)

Mean difference in change in Short Form 36 (SF36) from baseline to 24 weeks. Crude subscale scores for each group are not shown (each crude subscale is scored 0 to 100 at baseline and 24 weeks); higher mean differences in change from baseline to 24 weeks within groups indicate greater change on the subscales for that group. (NCT02158806)
Timeframe: Baseline, 24 weeks

,
Interventionunits on a scale (Mean)
Physical FunctioningRole PhysicalBodily PainGeneral HealthVitalitySocial FunctioningRole EmotionalMental Health
Aspirin5.011.711.4-1.13.95.810.5-1.2
Placebo3.810.39.0-0.8-0.34.96.81.2

Reviews

3 reviews available for aspirin and Leg Ulcer

ArticleYear
Optimal management of chronic leg ulcers in the elderly.
    Drugs & aging, 1997, Volume: 10, Issue:5

    Topics: Administration, Oral; Aged; Aging; Arterial Occlusive Diseases; Aspirin; Bandages; Combined Modality

1997
Management of arterial leg ulcers and of combined (mixed) venous-arterial leg ulcers.
    Current problems in dermatology, 1999, Volume: 27

    Topics: Alprostadil; Arterial Occlusive Diseases; Aspirin; Bandages; Electric Stimulation Therapy; Exercise

1999
[Klinefelter's syndrome and leg ulcers: role of blood coagulation disorders].
    Annales de dermatologie et de venereologie, 1992, Volume: 119, Issue:12

    Topics: Adult; Aspirin; Blood Coagulation Disorders; Gonadal Steroid Hormones; Humans; Klinefelter Syndrome;

1992

Trials

3 trials available for aspirin and Leg Ulcer

ArticleYear
Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU).
    BMJ (Clinical research ed.), 2017, Nov-24, Volume: 359

    Topics: Adjuvants, Pharmaceutic; Adult; Aged; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method

2017
Low-dose aspirin as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU).
    Journal of advanced nursing, 2016, Volume: 72, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Compression Bandages; Cost-Benefit Analysis; Dose-Response

2016
Successful treatment of livedo vasculitis with beraprost sodium: a possible mechanism of thrombomodulin upregulation.
    Dermatology (Basel, Switzerland), 1996, Volume: 192, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Child; Drug Therapy, Combination; Epidermis; Epoprostenol; Female;

1996

Other Studies

19 other studies available for aspirin and Leg Ulcer

ArticleYear
Rationale for participation in venous leg ulcer clinical research: Patient interview study.
    International wound journal, 2020, Volume: 17, Issue:6

    Topics: Aged; Aged, 80 and over; Aspirin; Female; Humans; Leg Ulcer; Male; Middle Aged; Motivation; Patient

2020
Refractory leg ulcers in prolidase deficiency with antiphospholipid antibody positivity responding to aspirin-hydroxychloroquine-vitamin C combination therapy.
    Dermatologic therapy, 2020, Volume: 33, Issue:6

    Topics: Antibodies, Antiphospholipid; Ascorbic Acid; Aspirin; Humans; Hydroxychloroquine; Leg Ulcer; Prolida

2020
Unilateral livedoid vasculopathy associated with involutional phase of cutaneous infantile hemangioma: the connection to coagulation disorders.
    The international journal of lower extremity wounds, 2013, Volume: 12, Issue:4

    Topics: Adolescent; Aspirin; Biopsy; Blood Coagulation Disorders; Blood Coagulation Tests; Diagnosis, Differ

2013
Livedoid vasculopathy (LV) associated with sticky platelets syndrome type 3 (SPS type 3) and enhanced activity of plasminogen activator inhibitor (PAI-1) anomalies.
    International journal of dermatology, 2014, Volume: 53, Issue:12

    Topics: Aspirin; Blood Platelets; Child; Female; Humans; Leg Ulcer; Plasminogen Activator Inhibitor 1; Plate

2014
Wound ulcer recruits needed.
    Australian nursing & midwifery journal, 2015, Volume: 23, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Humans; Leg Ulcer; Middle

2015
Aspirin can aid bandage as the best treatment for leg ulcers.
    Nursing older people, 2016, May-27, Volume: 28, Issue:5

    Topics: Aspirin; Compression Bandages; Humans; Leg Ulcer; Varicose Ulcer; Wound Healing

2016
Venous leg ulcer study needs more participants.
    Nursing New Zealand (Wellington, N.Z. : 1995), 2016, Volume: 22, Issue:3

    Topics: Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Leg Ulcer; Vascular Dis

2016
[Livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2004, Volume: 55, Issue:4

    Topics: Activated Protein C Resistance; Anticoagulants; Aspirin; Blood Platelets; Factor V; Fibrinolytic Age

2004
Antiphospholipid syndrome in a child: an insight into the pathology, identification, and means of cure.
    Journal of pediatric surgery, 2004, Volume: 39, Issue:8

    Topics: Antibodies, Anticardiolipin; Anticoagulants; Antiphospholipid Syndrome; Arterial Occlusive Diseases;

2004
Practical approach to treating essential thrombocythaemia: case studies.
    European journal of haematology. Supplementum, 2007, Issue:68

    Topics: Adult; Aspirin; Disease Management; Female; Humans; Hydroxyurea; Interferon-alpha; Leg Ulcer; Male;

2007
Lower limb salvage by microvascular free-tissue transfer in patients with homozygous sickle cell disease.
    Plastic and reconstructive surgery, 1995, Volume: 96, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Anti-Bacterial Agents; Aspirin; Dextrans; Exchange Transfusion, Whole Bl

1995
Does aspirin heal leg ulcers?
    The Journal of family practice, 1995, Volume: 40, Issue:1

    Topics: Administration, Oral; Aspirin; Bandages; Chronic Disease; Combined Modality Therapy; Double-Blind Me

1995
[Anticardiolipin syndrome with only skin involvement].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1994, Volume: 45, Issue:6

    Topics: Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Arm; Aspirin; Azathioprine; Combined

1994
In vitro model(s) for the percutaneous delivery of active tissue repair agents.
    Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:12

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Aspirin; Bridged Bicyclo Compounds, He

1997
Healing of necrobiotic ulcers with antiplatelet therapy. Correlation with plasma thromboxane levels.
    International journal of dermatology, 1989, Volume: 28, Issue:3

    Topics: Adult; Aged; Aspirin; Blood Platelets; Dipyridamole; Drug Therapy, Combination; Humans; Leg Ulcer; M

1989
Successful combined medical and surgical treatment of a lower extremity sclerodermal ulcer.
    Annals of plastic surgery, 1988, Volume: 20, Issue:6

    Topics: Aged; Aspirin; Combined Modality Therapy; Debridement; Dipyridamole; Etidronic Acid; Female; Humans;

1988
Treatment of sickle-cell disease.
    British journal of haematology, 1974, Volume: 28, Issue:4

    Topics: Anemia, Sickle Cell; Anesthesia; Anticoagulants; Aspirin; Bicarbonates; Blood; Blood Flow Velocity;

1974
Clinical and therapeutical problems concerning postthrombotic indurations.
    Acta Universitatis Carolinae. Medica. Monographia, 1972, Volume: 52

    Topics: Ascorbic Acid; Aspirin; Atrophy; Auscultation; Cellulitis; Drug Combinations; Edema; Humans; Leg Ulc

1972
[Clinical therapy of leg ulcer and thrombophlebitis using Colfarit].
    Die Medizinische Welt, 1973, Jun-15, Volume: 24, Issue:24

    Topics: Aspirin; Humans; Leg; Leg Ulcer; Thrombophlebitis

1973