aspirin has been researched along with Labor, Premature in 57 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study is to determine whether low-dose aspirin (LDA) reduced the rate of preterm birth (PTB) in a cohort of women at high risk for preeclampsia." | 9.22 | The impact of low-dose aspirin on preterm birth: secondary analysis of a randomized controlled trial. ( Allshouse, AA; Heyborne, KD; Jessel, RH, 2016) |
| "Women with a twofold or greater longitudinal reduction in maternal serum thromboxane B2 had less preeclampsia and prematurity, fewer small-for-gestational-age newborns, and higher birth weights than women with less than a twofold reduction." | 9.08 | Maternal serum thromboxane B2 reduction versus pregnancy outcome in a low-dose aspirin trial. ( Copper, RL; Cutter, GR; Goldenberg, RL; Hauth, JC; Parker, CR, 1995) |
| "A collaborative randomised trial comparing the effects of low dose aspirin (60 mg) with placebo on pre-eclampsia and other materno-fetal complications associated with hypertension." | 9.08 | ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. ECPPA (Estudo Colaborativo para Prevenção da Pré-eclampsia com Aspirina) Collaborative Group. ( , 1996) |
| "We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes." | 8.82 | Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis. ( Boskovic, R; Costei, AM; Koren, G; Kozer, E; Nikfar, S; Nulman, I, 2003) |
| "Verify that resistance to aspirin may have an impact on pregnancy and neonatal outcome." | 7.77 | Aspirin resistance may be associated with adverse pregnancy outcomes. ( Huras, H; Jach, R; Musiał, J; Reroń, A; Rytlewski, K; Undas, A; Wilczak, M; Wójtowicz, A, 2011) |
| "Aspirin was also associated with a reduction in rates of spontaneous preterm birth (OR 0." | 6.42 | Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review. ( Coomarasamy, A; Gee, H; Honest, H; Khan, KS; Papaioannou, S, 2003) |
| "In this study, we observed that low-dose aspirin did not significantly reduce the preterm birth rate in women with a previous spontaneous preterm birth." | 5.51 | Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial. ( Bekker, MN; Boon, J; de Boer, MA; de Groot, CJM; Franssen, MTM; Hemels, MAC; Hermes, W; Huisjes, AJM; Kleiverda, G; Landman, AJEMC; Mol, BW; Naaktgeboren, CN; Nijman, TAJ; Oudijk, MA; Papatsonis, DNM; Sikkema, JM; Sueters, M; van der Ham, DP; van der Weide, MC; van Drongelen, J; van Huizen, ME; van Laar, JOEH; van Pampus, MG; Visser, H; Visser, L; Zwart, JJ, 2022) |
| "The objective of this study is to determine whether low-dose aspirin (LDA) reduced the rate of preterm birth (PTB) in a cohort of women at high risk for preeclampsia." | 5.22 | The impact of low-dose aspirin on preterm birth: secondary analysis of a randomized controlled trial. ( Allshouse, AA; Heyborne, KD; Jessel, RH, 2016) |
| "To compare the effect of aspirin and enoxaparin on live births in women with unexplained recurrent miscarriages, as well as secondary outcomes including birth weight, uterine and umbilical blood flows, and congenital malformations." | 5.12 | A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages. ( Brenner, B; Carp, H; Dolitzky, M; Inbal, A; Segal, Y; Weiss, A, 2006) |
| "Women with a twofold or greater longitudinal reduction in maternal serum thromboxane B2 had less preeclampsia and prematurity, fewer small-for-gestational-age newborns, and higher birth weights than women with less than a twofold reduction." | 5.08 | Maternal serum thromboxane B2 reduction versus pregnancy outcome in a low-dose aspirin trial. ( Copper, RL; Cutter, GR; Goldenberg, RL; Hauth, JC; Parker, CR, 1995) |
| "A collaborative randomised trial comparing the effects of low dose aspirin (60 mg) with placebo on pre-eclampsia and other materno-fetal complications associated with hypertension." | 5.08 | ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. ECPPA (Estudo Colaborativo para Prevenção da Pré-eclampsia com Aspirina) Collaborative Group. ( , 1996) |
| "8 mg per kilogram of body weight per day) and aspirin (100 mg per day) or placebo for the duration of the pregnancy." | 5.08 | Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. ( Bombardier, C; Farewell, V; Farine, D; Fielding, L; Hannah, ME; Laskin, CA; Mandel, FP; Ritchie, JW; Soloninka, CA; Spitzer, K; Yeung, M, 1997) |
| "We compared the use of aspirin alone with combined therapy (prednisone plus aspirin) in antiphospholipid antibody-positive obstetric patients with prior adverse pregnancy outcome." | 5.07 | Comparative trial of prednisone plus aspirin versus aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients. ( Hobart, JM; MacGregor, SN; Neerhof, MG; Ragin, A; Sholl, JS; Silver, RK, 1993) |
| "Antiplatelet agents, largely low-dose aspirin, have moderate benefits when used for prevention of pre-eclampsia and its consequences." | 4.84 | Antiplatelet agents for preventing pre-eclampsia and its complications. ( Duley, L; Henderson-Smart, DJ; King, JF; Meher, S, 2007) |
| "We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes." | 4.82 | Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis. ( Boskovic, R; Costei, AM; Koren, G; Kozer, E; Nikfar, S; Nulman, I, 2003) |
| "Antiplatelet drugs, largely low dose aspirin, have small to moderate benefits when used for prevention of pre-eclampsia." | 4.81 | Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review. ( Duley, L; Henderson-Smart, D; King, J; Knight, M, 2001) |
| " This study aims to investigate whether calcium channel blockers plus low dosage aspirin therapy can reduce the incidence of complications during pregnancy with chronic hypertension and improve the prognosis of neonates." | 3.81 | The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension. ( Jiang, N; Liu, L; Liu, Q; Yang, WW; Zeng, Y, 2015) |
| "Verify that resistance to aspirin may have an impact on pregnancy and neonatal outcome." | 3.77 | Aspirin resistance may be associated with adverse pregnancy outcomes. ( Huras, H; Jach, R; Musiał, J; Reroń, A; Rytlewski, K; Undas, A; Wilczak, M; Wójtowicz, A, 2011) |
| " She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5." | 3.70 | Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998) |
| " Aspirin, 75 mg daily was given in addition to enoxaparin to women with antiphospholipid syndrome." | 3.70 | Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. ( Blumenfeld, Z; Brenner, B; Hoffman, R; Weiner, Z; Younis, JS, 2000) |
| "Miscarriage, premature delivery, and preeclampsia, as well as heart problems in the baby are the major complications that can occur." | 2.53 | Pregnancy in women with systemic lupus erythematosus (SLE). ( Moroni, G; Ponticelli, C, 2016) |
| "Aspirin was also associated with a reduction in rates of spontaneous preterm birth (OR 0." | 2.42 | Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review. ( Coomarasamy, A; Gee, H; Honest, H; Khan, KS; Papaioannou, S, 2003) |
| "There is also a risk of prematurity, intrauterine growth retardation and neonatal embolism." | 2.41 | A literature review on the antiphospholipid syndrome and the effect on childbearing. ( Vials, JM, 2001) |
| "Preeclampsia is characterized by a functional imbalance between vascular prostacyclin and thromboxane A2 production." | 2.38 | [Acetylsalicylic acid in pregnancy]. ( Egarter, C; Husslein, P; Karas, H, 1993) |
| "An autoimmune disease was present in seven (29%) cases." | 1.42 | Chronic histiocytic intervillositis: outcome, associated diseases and treatment in a multicenter prospective study. ( Botta, A; Bucourt, M; Carbillon, L; Chollet-Martin, S; Chudzinski, A; Cornelis, F; Costedoat-Chalumeau, N; De Carolis, S; Emmanuelli, V; Fain, O; Hachulla, E; Masseau, A; Mekinian, A; Montestruc, F; Nicaise, P; Revaux, A; Subtil, D; Theulin, A, 2015) |
| "Treatment with aspirin and LMWH is associated with improved outcomes for women with previous late fetal loss or early delivery due to placental dysfunction (Group 2)." | 1.36 | Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome. ( Bewley, S; Bramham, K; Calatayud, I; Germain, S; Hunt, BJ; Khamashta, M; Nelson-Piercy, C, 2010) |
| "Pregnancy was authorized if disease was inactive on 20 mg/day prednisone or less for at least 1 yr." | 1.30 | Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies. ( Blétry, O; Darbois, Y; Godeau, P; Lê Huong, D; Lefèbvre, G; Piette, JC; Seebacher, J; Vauthier-Brouzes, D; Wechsler, B, 1997) |
| " If preterm labour was stopped, the dosage had been reduced." | 1.26 | [Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)]. ( Berg, R; Bolte, A; Wolff, F, 1981) |
| "Prevention of premature labor is of considerable interest in research and clinics." | 1.25 | The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs. ( Mosler, KH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (42.11) | 18.7374 |
| 1990's | 11 (19.30) | 18.2507 |
| 2000's | 10 (17.54) | 29.6817 |
| 2010's | 10 (17.54) | 24.3611 |
| 2020's | 2 (3.51) | 2.80 |
| Authors | Studies |
|---|---|
| Landman, AJEMC | 1 |
| de Boer, MA | 2 |
| Visser, L | 2 |
| Nijman, TAJ | 2 |
| Hemels, MAC | 2 |
| Naaktgeboren, CN | 1 |
| van der Weide, MC | 1 |
| Mol, BW | 1 |
| van Laar, JOEH | 1 |
| Papatsonis, DNM | 1 |
| Bekker, MN | 2 |
| van Drongelen, J | 2 |
| van Pampus, MG | 1 |
| Sueters, M | 2 |
| van der Ham, DP | 1 |
| Sikkema, JM | 2 |
| Zwart, JJ | 1 |
| Huisjes, AJM | 1 |
| van Huizen, ME | 1 |
| Kleiverda, G | 1 |
| Boon, J | 1 |
| Franssen, MTM | 2 |
| Hermes, W | 1 |
| Visser, H | 1 |
| de Groot, CJM | 2 |
| Oudijk, MA | 2 |
| Gangat, N | 1 |
| Guglielmelli, P | 1 |
| Al-Kali, A | 1 |
| Wolanskyj-Spinner, AP | 1 |
| Camoriano, J | 1 |
| Patnaik, MM | 1 |
| Pardanani, A | 1 |
| Hanson, CA | 1 |
| Vannucchi, AM | 1 |
| Tefferi, A | 2 |
| Bloemenkamp, KWM | 1 |
| Bosmans, JE | 1 |
| Kok, M | 1 |
| van Laar, JO | 1 |
| Scheepers, H | 1 |
| Duvekot, HJJ | 1 |
| van der Post, JAM | 1 |
| Naaktgeboren, C | 1 |
| Mol, BWJ | 1 |
| Li, YY | 1 |
| Gu, QR | 1 |
| Chen, GR | 1 |
| Quinn, MJ | 1 |
| Mekinian, A | 1 |
| Costedoat-Chalumeau, N | 1 |
| Masseau, A | 1 |
| Botta, A | 1 |
| Chudzinski, A | 1 |
| Theulin, A | 1 |
| Emmanuelli, V | 1 |
| Hachulla, E | 1 |
| De Carolis, S | 1 |
| Revaux, A | 1 |
| Nicaise, P | 1 |
| Cornelis, F | 1 |
| Subtil, D | 1 |
| Montestruc, F | 1 |
| Bucourt, M | 1 |
| Chollet-Martin, S | 1 |
| Carbillon, L | 1 |
| Fain, O | 1 |
| Jiang, N | 1 |
| Liu, Q | 1 |
| Liu, L | 1 |
| Yang, WW | 1 |
| Zeng, Y | 1 |
| Allshouse, AA | 1 |
| Jessel, RH | 1 |
| Heyborne, KD | 1 |
| Moroni, G | 1 |
| Ponticelli, C | 1 |
| Roumi, JE | 1 |
| Moukhadder, HM | 1 |
| Graziadei, G | 1 |
| Pennisi, M | 1 |
| Cappellini, MD | 1 |
| Taher, AT | 1 |
| Bramham, K | 1 |
| Hunt, BJ | 1 |
| Germain, S | 1 |
| Calatayud, I | 1 |
| Khamashta, M | 1 |
| Bewley, S | 1 |
| Nelson-Piercy, C | 1 |
| Wójtowicz, A | 1 |
| Undas, A | 1 |
| Huras, H | 1 |
| Musiał, J | 1 |
| Rytlewski, K | 1 |
| Reroń, A | 1 |
| Wilczak, M | 1 |
| Jach, R | 1 |
| Ayala, DE | 1 |
| Ucieda, R | 1 |
| Hermida, RC | 1 |
| Coomarasamy, A | 1 |
| Honest, H | 1 |
| Papaioannou, S | 1 |
| Gee, H | 1 |
| Khan, KS | 1 |
| Kozer, E | 1 |
| Costei, AM | 1 |
| Boskovic, R | 1 |
| Nulman, I | 1 |
| Nikfar, S | 1 |
| Koren, G | 1 |
| Dolitzky, M | 1 |
| Inbal, A | 1 |
| Segal, Y | 1 |
| Weiss, A | 1 |
| Brenner, B | 2 |
| Carp, H | 1 |
| Duley, L | 2 |
| Henderson-Smart, DJ | 1 |
| Meher, S | 1 |
| King, JF | 1 |
| Wolff, F | 5 |
| Bolte, A | 4 |
| Berg, R | 4 |
| Reimann, IW | 1 |
| Frölich, JC | 1 |
| Szekeres-Bartho, J | 1 |
| Csernus, V | 1 |
| Hadnagy, J | 1 |
| Pacsa, AS | 1 |
| Niebyl, JR | 2 |
| Pütter, J | 1 |
| Curtius, JM | 1 |
| Goeckenjan, G | 1 |
| Steyer, M | 1 |
| Hust, M | 1 |
| Hauth, JC | 1 |
| Goldenberg, RL | 1 |
| Parker, CR | 1 |
| Copper, RL | 1 |
| Cutter, GR | 1 |
| Karas, H | 1 |
| Egarter, C | 1 |
| Husslein, P | 1 |
| Silver, RK | 1 |
| MacGregor, SN | 1 |
| Sholl, JS | 1 |
| Hobart, JM | 1 |
| Neerhof, MG | 1 |
| Ragin, A | 1 |
| Laskin, CA | 1 |
| Bombardier, C | 1 |
| Hannah, ME | 1 |
| Mandel, FP | 1 |
| Ritchie, JW | 1 |
| Farewell, V | 1 |
| Farine, D | 1 |
| Spitzer, K | 1 |
| Fielding, L | 1 |
| Soloninka, CA | 1 |
| Yeung, M | 1 |
| Lê Huong, D | 1 |
| Wechsler, B | 1 |
| Vauthier-Brouzes, D | 1 |
| Seebacher, J | 1 |
| Lefèbvre, G | 1 |
| Blétry, O | 1 |
| Darbois, Y | 1 |
| Godeau, P | 1 |
| Piette, JC | 1 |
| Cook, JL | 1 |
| Randall, CL | 1 |
| Carrero, EJ | 1 |
| Agustí, M | 1 |
| Fábregas, N | 1 |
| Valldeoriola, F | 1 |
| Fernández, C | 1 |
| Hoffman, R | 1 |
| Blumenfeld, Z | 1 |
| Weiner, Z | 1 |
| Younis, JS | 1 |
| Henderson-Smart, D | 1 |
| Knight, M | 1 |
| King, J | 1 |
| Wright, CA | 1 |
| Vials, JM | 1 |
| Maharaj, R | 1 |
| Kutteh, WH | 1 |
| Béguin, F | 1 |
| Mosler, KH | 3 |
| Linka, F | 2 |
| Karim, SM | 1 |
| Meier, U | 1 |
| Klingspohr, HJ | 1 |
| Babenerd, J | 1 |
| Kyriakidis, K | 1 |
| Plum, H | 1 |
| Fuller, WE | 1 |
| Dry, J | 1 |
| Sibai, BM | 1 |
| Cohen, AW | 1 |
| Keirse, MJ | 1 |
| Witter, FR | 1 |
| Zeller, G | 1 |
| Dudenhausen, JW | 1 |
| Jankowski, A | 1 |
| Skublicki, S | 1 |
| Wichliński, LM | 1 |
| Szymański, W | 1 |
| Waltman, R | 1 |
| Tricomi, V | 1 |
| Landesman, R | 1 |
| Fuchs, F | 1 |
| Dornhöfer, W | 1 |
| Eriksson, M | 1 |
| Chester, R | 1 |
| Dukes, M | 1 |
| Slater, SR | 1 |
| Walpole, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers[NCT01729468] | Phase 4 | 1,106 participants (Actual) | Interventional | 2012-06-27 | Completed | ||
| Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
| A Randomized Controlled Trial Comparing Low Doses Of Aspirin In The Prevention Of Preeclampsia (ASAPP)[NCT04070573] | Phase 3 | 400 participants (Anticipated) | Interventional | 2019-10-21 | Enrolling by invitation | ||
| Genetic, Laboratory and Clinical Factors Associated With Low-dose Aspirin Failure in the Prevention of Preeclampsia- An Exploratory Protocol[NCT05709483] | Early Phase 1 | 130 participants (Anticipated) | Interventional | 2023-04-13 | Recruiting | ||
| Low Dose Aspirin in the Prevention of Preeclampsia in Chinese Pregnant Women.[NCT02797249] | Phase 3 | 1,000 participants (Actual) | Interventional | 2016-12-07 | Completed | ||
| PEPPI Study: Identification of Women at Risk for Placental Dysfunction During the First and Third Trimesters of Pregnancy[NCT06115122] | 3,000 participants (Anticipated) | Observational [Patient Registry] | 2022-02-15 | Recruiting | |||
| Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension: A Pilot Study[NCT04908982] | Phase 4 | 60 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | ||
| Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss[NCT04558268] | Phase 2/Phase 3 | 242 participants (Anticipated) | Interventional | 2020-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 189 |
| Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1078 |
| Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 78 |
| Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 303 |
| Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 134 |
| Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 141 |
| Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 42 |
| Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 352 |
| Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 264 |
| Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 668 |
| Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1506 |
| Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 214 |
| Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 26 |
| Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 54 |
| Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 9 |
| Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 23 |
| Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 290 |
| Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 8 |
| Placebo Arm | 21 |
17 reviews available for aspirin and Labor, Premature
| Article | Year |
|---|---|
Pregnancy in women with systemic lupus erythematosus (SLE).
Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspi | 2016 |
Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review.
Topics: Aspirin; Birth Weight; Female; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Obstetr | 2003 |
Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Weight; | 2003 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
Antiplatelet agents for preventing pre-eclampsia and its complications.
Topics: Aspirin; Female; Fetal Death; Humans; Obstetric Labor, Premature; Platelet Aggregation Inhibitors; P | 2007 |
[Risks of simultaneous tocolytic treatment with beta adrenergic and PG inhibiting agents].
Topics: Adrenergic beta-Antagonists; Aspirin; Drug Interactions; Drug Therapy, Combination; Female; Humans; | 1981 |
Preterm parturition. Prostaglandin synthetase inhibitors.
Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P | 1981 |
[Acetylsalicylic acid in pregnancy].
Topics: Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; E | 1993 |
Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review.
Topics: Aspirin; Female; Fetal Death; Humans; Infant, Newborn; Obstetric Labor, Premature; Platelet Aggregat | 2001 |
A single institutional experience with 43 pregnancies in essential thrombocythemia.
Topics: Abortion, Induced; Abortion, Spontaneous; Abruptio Placentae; Adult; Anticoagulants; Aspirin; Busulf | 2001 |
A literature review on the antiphospholipid syndrome and the effect on childbearing.
Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Embolism; Female; Fetal Death; Fetal Diseases; F | 2001 |
Do acetylsalicylic acid and other antiplatelet drugs prevent preeclampsia?
Topics: Aspirin; Autoimmune Diseases; Clinical Trials as Topic; Diabetes Complications; Dose-Response Relati | 2001 |
Autoimmune factors in assisted reproduction.
Topics: Abortion, Habitual; Abortion, Spontaneous; Adrenal Cortex Hormones; Antibodies, Anticardiolipin; Ant | 2002 |
[Clinical pharmacology in obstetrics: regulation of the uterus].
Topics: Adrenergic beta-Agonists; Aspirin; Ergotamine; Female; Humans; Indomethacin; Methylergonovine; Obste | 1975 |
On the use of blockers of prostaglandin synthesis in the control of labor.
Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome | 1978 |
An aspirin a day to prevent prematurity.
Topics: Aspirin; Birth Weight; Female; Fetal Growth Retardation; Health Status Indicators; Humans; Obstetric | 1992 |
Prenatal care, screening, and complications.
Topics: alpha-Fetoproteins; Aspirin; Blood Transfusion, Autologous; Female; Humans; Mass Screening; Neural T | 1991 |
Control of uterine activity and prevention of premature birth.
Topics: Adrenergic beta-Antagonists; Aspirin; Blood Pressure; Diazoxide; Epinephrine; Ethanol; Female; Fetal | 1974 |
14 trials available for aspirin and Labor, Premature
| Article | Year |
|---|---|
Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Netherlands; | 2022 |
Low dose aspirin in the prevention of recurrent spontaneous preterm labour - the APRIL study: a multicenter randomized placebo controlled trial.
Topics: Adolescent; Adult; Aspirin; Cost-Benefit Analysis; Double-Blind Method; Female; Gestational Age; Hum | 2017 |
The impact of low-dose aspirin on preterm birth: secondary analysis of a randomized controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Female; F | 2016 |
Chronotherapy with low-dose aspirin for prevention of complications in pregnancy.
Topics: Adult; Aspirin; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Double-Blind Method; Drug A | 2013 |
A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages.
Topics: Abortion, Habitual; Abortion, Induced; Adult; Anticoagulants; Aspirin; Birth Rate; Birth Weight; Eno | 2006 |
Influence of treatment with prostaglandin synthesis inhibitor or progesterone on cytotoxic activity and progesterone binding capacity of lymphocytes during pregnancy.
Topics: 17-alpha-Hydroxyprogesterone; Aspirin; Cytotoxicity, Immunologic; Female; Humans; Hydroxyprogesteron | 1983 |
Maternal serum thromboxane B2 reduction versus pregnancy outcome in a low-dose aspirin trial.
Topics: Aspirin; Birth Weight; Double-Blind Method; Embryonic and Fetal Development; Female; Humans; Obstetr | 1995 |
Comparative trial of prednisone plus aspirin versus aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients.
Topics: Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Aspirin; Drug Therapy, Combination; F | 1993 |
ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. ECPPA (Estudo Colaborativo para Prevenção da Pré-eclampsia com Aspirina) Collaborative Group.
Topics: Aspirin; Birth Weight; Female; Fetal Death; Fetal Growth Retardation; Follow-Up Studies; Humans; Obs | 1996 |
Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss.
Topics: Abortion, Habitual; Adolescent; Adult; Aspirin; Autoantibodies; Female; Fetal Membranes, Premature R | 1997 |
On the use of blockers of prostaglandin synthesis in the control of labor.
Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome | 1978 |
[Effect of fenoterol (Partusisten) on the oxygen dissociation curve in pregnant women (author's transl)].
Topics: Acid-Base Equilibrium; Aspirin; Clinical Trials as Topic; Drug Therapy, Combination; Erythrocytes; E | 1978 |
Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects.
Topics: Administration, Oral; Arachidonic Acid; Arachidonic Acids; Aspirin; Clinical Trials as Topic; Cycloo | 1986 |
[Indications for tocolysis. A prospective study].
Topics: Aspirin; Betamethasone; Clenbuterol; Drug Therapy, Combination; Ethanol; Ethanolamines; Female; Feno | 1986 |
27 other studies available for aspirin and Labor, Premature
| Article | Year |
|---|---|
Pregnancy in patients with myelofibrosis: Mayo-Florence series of 24 pregnancies in 16 women.
Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Diabetes, Gestational; Female; Fetal Death; Hemo | 2021 |
Preventing preterm preeclampsia.
Topics: Aspirin; Female; Humans; Infant, Newborn; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Prem | 2018 |
Chronic histiocytic intervillositis: outcome, associated diseases and treatment in a multicenter prospective study.
Topics: Abortion, Habitual; Adult; Aspirin; Autoantibodies; Autoimmune Diseases; Cell Movement; Chorionic Vi | 2015 |
The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension.
Topics: Adult; Amlodipine; Aspirin; Birth Weight; Blood Pressure; Calcium Channel Blockers; China; Female; H | 2015 |
Pregnancy in β-thalassemia intermedia at two tertiary care centers in Lebanon and Italy: A follow-up report on fetal and maternal outcomes.
Topics: Abortion, Habitual; Abortion, Spontaneous; Aspirin; beta-Thalassemia; Birth Weight; Cesarean Section | 2017 |
Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome.
Topics: Adult; Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Infant, Ne | 2010 |
Aspirin resistance may be associated with adverse pregnancy outcomes.
Topics: Adult; Aspirin; Cesarean Section; Drug Resistance; Female; Fetal Distress; Humans; Infant, Newborn; | 2011 |
[Does an additional administration of acetylsalicylic acid reduce the requirement of betamimetics in tocolytic treatment? (author's transl)].
Topics: Adrenergic beta-Agonists; Aspirin; Cervix Uteri; Drug Therapy, Combination; Ethanolamines; Female; F | 1981 |
[Clinical study of the labour inhibiting effects an side effects of acetylsalicylic acid (ASA) (author's transl)].
Topics: Aspirin; Female; Fenoterol; Headache; Humans; Hyperventilation; Obstetric Labor, Premature; Pregnanc | 1981 |
Perinatal pharmacokinetics of acetylsalicylic acid.
Topics: Aspirin; Female; Fetal Blood; Humans; Infant, Newborn; Kinetics; Obstetric Labor, Premature; Pregnan | 1982 |
[Pulmonary oedema as a complication of tocolytic therapy (author's transl)].
Topics: Adult; Aspirin; Autopsy; Betamethasone; Ethanolamines; Female; Fenoterol; Humans; Obstetric Labor, P | 1980 |
Outcome of planned pregnancies in systemic lupus erythematosus: a prospective study on 62 pregnancies.
Topics: Adrenal Cortex Hormones; Aging; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1997 |
Early onset of parturition induced by acute alcohol exposure in C57BL/6J mice: role of uterine PGE and PGF2alpha.
Topics: Animals; Aspirin; Dinoprost; Ethanol; Female; Fetus; Labor, Obstetric; Mice; Mice, Inbred C57BL; Obs | 1997 |
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No | 1998 |
Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin.
Topics: 3' Untranslated Regions; Abortion, Habitual; Activated Protein C Resistance; Adult; Anticoagulants; | 2000 |
[Prevention of premature labor].
Topics: Adrenergic beta-Agonists; Aspirin; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnan | 1975 |
The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Aspirin; Calcium; Drug Therapy, Combina | 1975 |
[Prevention of premature delivery with acetylsalicylic acid].
Topics: Adult; Aspirin; Female; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Obstetric Labo | 1979 |
[Results of labor-inhibiting treatment with high doses of intravenously administered acetylsalicylic acid (proceedings)].
Topics: Aspirin; Female; Humans; Infusions, Parenteral; Obstetric Labor, Premature; Pregnancy; Uterine Contr | 1977 |
Management of premature labor.
Topics: Aspirin; Bed Rest; Betamethasone; Estrogens; Ethanol; Female; Fetal Membranes, Premature Rupture; Gl | 1978 |
[The therapeutic year].
Topics: Albuterol; Anti-Inflammatory Agents; Aspirin; Calcitonin; Colchicine; Drug Therapy; Endocrine System | 1976 |
[Aspirin and pregnancy].
Topics: Aspirin; Blood Coagulation Factors; Female; Fetal Death; Fetal Growth Retardation; Humans; Hypertens | 1990 |
Clinical-pharmacokinetic investigations of acetylsalicylic acid in cases of imminent premature delivery.
Topics: Amniotic Fluid; Aspirin; Female; Fetal Blood; Humans; Infant, Newborn; Kinetics; Obstetric Labor, Pr | 1985 |
Letter: Salicylates and pregnancy.
Topics: Abortion, Threatened; Animals; Aspirin; Drug Antagonism; Drug Evaluation; Female; Fetus; Humans; Obs | 1974 |
[Inhibition of premature labour--anti-inflammatory agents in the prevention of premature birth (author's transl)].
Topics: Administration, Oral; Anti-Inflammatory Agents; Aspirin; Blood Pressure; Blood Vessels; Drug Therapy | 1974 |
Salicylate-induced foetal damage late in pregnancy. An experimental study in mice.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Carbon Isotopes; Coumarins; Female; | 1971 |
Delay of parturition in the rat by anti-inflammatory agents which inhibit the biosynthesis of prostaglandins.
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Cortisone; Depression, C | 1972 |