Page last updated: 2024-10-23

aspirin and Kidney Diseases

aspirin has been researched along with Kidney Diseases in 251 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
"001) by adjusted-dose warfarin compared with aspirin/low-dose warfarin; there was no difference in major hemorrhage (5 patients versus 6 patients, respectively)."9.15Warfarin in atrial fibrillation patients with moderate chronic kidney disease. ( Asinger, RW; Hart, RG; Herzog, CA; Pearce, LA, 2011)
"We randomly assigned patients who had adenomas removed before study entry to receive placebo (679 patients) or 200 mg (685 patients) or 400 mg (671 patients) of celecoxib twice daily."9.12Celecoxib for the prevention of sporadic colorectal adenomas. ( Anderson, WF; Bagheri, D; Bertagnolli, MM; Boisserie, F; Burn, J; Chung, DC; Corle, D; Dewar, T; Eagle, CJ; Foley, TR; Gordon, GB; Hawk, ET; Hess, TM; Hoffman, N; Kim, K; Macrae, F; Pruitt, RE; Redston, M; Rosenstein, RB; Saltzman, JR; Salzberg, B; Solomon, SD; Sylwestrowicz, T; Tang, J; Viner, JL; Wittes, J; Woloj, GM; Zauber, AG, 2006)
"The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the COX-2 inhibitor celecoxib given daily in a single 400-mg dose."9.12Celecoxib for the prevention of colorectal adenomatous polyps. ( Arber, N; Bhadra, P; Dite, P; Eagle, CJ; Fowler, R; Gerletti, P; Hajer, J; Lechuga, MJ; Levin, B; Macdonald, K; Rácz, I; Rosenstein, RB; Solomon, SD; Spicak, J; Tang, J; Wittes, J; Zauber, AG; Zavoral, M, 2006)
"This report presents information on the effects of aspirin on mortality, the occurrence of cardiovascular events, and the incidence of kidney disease in the patients enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS)."9.07Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS Investigators. ( , 1992)
"Benzbromarone1 is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects."8.75Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977)
"Although aspirin-clopidogrel combination is more useful for acute coronary syndrome (ACS), the renal safety of this combination had not been established."7.83Short Communication: Evaluation of nephrotoxicity by aspirin-clopidogrel combination therapy in patients with acute coronary syndrome. ( Baber, M; HamidAkash, MS; Hussain, SB; Irfan, M; Qadir, MI; Rehman, A, 2016)
" There was a lower rate of catheter-associated S aureus bacteremia in patients treated with aspirin versus those not treated with aspirin (0."7.74Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled catheters. ( Bayer, AS; Cheung, AL; Gemery, JM; Remillard, BD; Sedlacek, M, 2007)
"The safety of aspirin in heart failure (HF) has been called into question, particularly in those patients (1) without coronary disease, (2) with renal dysfunction, or (3) treated with low-dose angiotensin-converting enzyme (ACE) inhibitors and high-dose aspirin."7.73Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. ( Armstrong, PW; Fang, J; Ghali, WA; Gong, Y; McAlister, FA; Tu, JV, 2006)
"Aspirin reduced the rate of early graft thrombosis of renal transplants in this series but did not improve renal function or graft survival."7.71Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation. ( Metcalfe, M; Murphy, GJ; Nicholson, ML; Taha, R; Windmill, DC, 2001)
"Three children with the hemolytic-uremic syndrome were treated with heparin, aspirin, and dipyridamole."7.65Preliminary report: treatment of the hemolytic-uremic syndrome with aspirin and dipyridamole. ( Arenson, EB; August, CS, 1975)
"A review is given on the clinical studies performed with aspirin in patients with chronic vascular occlusions of the limbs and on studies in cerebral ischemia using aspirin and sulfinpyrazone."6.14Use of platelet inhibitor drugs in peripheral and cerebral vascular disorders. ( Breddin, K, 1977)
"001) by adjusted-dose warfarin compared with aspirin/low-dose warfarin; there was no difference in major hemorrhage (5 patients versus 6 patients, respectively)."5.15Warfarin in atrial fibrillation patients with moderate chronic kidney disease. ( Asinger, RW; Hart, RG; Herzog, CA; Pearce, LA, 2011)
"The HOT (Hypertension Optimal Treatment) study randomly assigned participants with diastolic hypertension to aspirin (75 mg) or placebo."5.14Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial. ( Cass, A; Chalmers, J; Gallagher, MP; Jardine, MJ; Lambers Heerspink, HJ; Ninomiya, T; Perkovic, V; Turnbull, F; Zanchetti, A; Zoungas, S, 2010)
"We randomly assigned patients who had adenomas removed before study entry to receive placebo (679 patients) or 200 mg (685 patients) or 400 mg (671 patients) of celecoxib twice daily."5.12Celecoxib for the prevention of sporadic colorectal adenomas. ( Anderson, WF; Bagheri, D; Bertagnolli, MM; Boisserie, F; Burn, J; Chung, DC; Corle, D; Dewar, T; Eagle, CJ; Foley, TR; Gordon, GB; Hawk, ET; Hess, TM; Hoffman, N; Kim, K; Macrae, F; Pruitt, RE; Redston, M; Rosenstein, RB; Saltzman, JR; Salzberg, B; Solomon, SD; Sylwestrowicz, T; Tang, J; Viner, JL; Wittes, J; Woloj, GM; Zauber, AG, 2006)
"The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the COX-2 inhibitor celecoxib given daily in a single 400-mg dose."5.12Celecoxib for the prevention of colorectal adenomatous polyps. ( Arber, N; Bhadra, P; Dite, P; Eagle, CJ; Fowler, R; Gerletti, P; Hajer, J; Lechuga, MJ; Levin, B; Macdonald, K; Rácz, I; Rosenstein, RB; Solomon, SD; Spicak, J; Tang, J; Wittes, J; Zauber, AG; Zavoral, M, 2006)
"Low-dose aspirin and diuretics are commonly co-utilized in patients with cardiovascular diseases."5.12Potential adverse effects of a low-dose aspirin-diuretic combination on kidney function. ( Sweileh, WM, 2007)
"During a 1-year treatment period, simvastatin, 20 mg/d, produced a sustained reduction of approximately one quarter in low-density lipoprotein cholesterol levels, with no evidence of toxicity, and aspirin, 100 mg/d, did not substantially increase the risk for a major bleeding episode."5.11First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. ( Altmann, P; Armitage, J; Baigent, C; Baxter, A; Cairns, HS; Collins, R; Foley, RN; Frighi, V; Kourellias, K; Landray, M; Leaper, C; Ratcliffe, PJ; Rogerson, M; Scoble, JE; Tomson, CR; Warwick, G; Wheeler, DC, 2005)
"This report presents information on the effects of aspirin on mortality, the occurrence of cardiovascular events, and the incidence of kidney disease in the patients enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS)."5.07Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS Investigators. ( , 1992)
"The present review focuses on the roles of thromboxane A2 (TxA2) in arterial thrombosis, atherogenesis, vascular stent-related ischemic events and renal proteinuria."4.85Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases. ( Alberts, P; Bounameaux, H; Fontana, P; Mann, J; Sakariassen, KS; Sorensen, AS, 2009)
" Thus, physiological and pathophysiological roles of COX-2 were considered from the standpoint of clinical effects of the two latest COX-2 selective inhibitors, celecoxib and rofecoxib, on inflammation, pain, fever and colorectal cancer together with their adverse effects on gastrointestinal, renal and platelet functions; and the usefulness and limits of COX-2-selective inhibitors were discussed with the trends of new NSAIDs development."4.81[Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors]. ( Nakamura, H, 2001)
" Aspirin and all nonsalicylate NSAIDs share a risk of causing gastric ulcer, upper GI bleeding, and GI perforation."4.78Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis. A review and suggestions. ( Greene, JM; Winickoff, RN, 1992)
"Benzbromarone1 is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects."4.75Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1977)
"Although aspirin-clopidogrel combination is more useful for acute coronary syndrome (ACS), the renal safety of this combination had not been established."3.83Short Communication: Evaluation of nephrotoxicity by aspirin-clopidogrel combination therapy in patients with acute coronary syndrome. ( Baber, M; HamidAkash, MS; Hussain, SB; Irfan, M; Qadir, MI; Rehman, A, 2016)
" There was a lower rate of catheter-associated S aureus bacteremia in patients treated with aspirin versus those not treated with aspirin (0."3.74Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled catheters. ( Bayer, AS; Cheung, AL; Gemery, JM; Remillard, BD; Sedlacek, M, 2007)
"The safety of aspirin in heart failure (HF) has been called into question, particularly in those patients (1) without coronary disease, (2) with renal dysfunction, or (3) treated with low-dose angiotensin-converting enzyme (ACE) inhibitors and high-dose aspirin."3.73Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. ( Armstrong, PW; Fang, J; Ghali, WA; Gong, Y; McAlister, FA; Tu, JV, 2006)
"Aspirin reduced the rate of early graft thrombosis of renal transplants in this series but did not improve renal function or graft survival."3.71Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation. ( Metcalfe, M; Murphy, GJ; Nicholson, ML; Taha, R; Windmill, DC, 2001)
"Regular use of analgesic drugs containing phenacetin is associated with an increased risk of hypertension and mortality and morbidity due to cardiovascular disease, as well as an increased risk of mortality due to cancer and urologic or renal disease."3.68An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) ( Dubach, UC; Rosner, B; Stürmer, T, 1991)
"Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness."3.66An update on long-term efficacy and safety with benoxaprofen. ( Mikulaschek, WM, 1982)
"Renal function was studied in 17 patients with rheumatoid arthritis who had each consumed between 5 and 20 kg of aspirin."3.65Aspirin and analgesic nephropathy. ( Craft, AW; Kerr, DN; Macklon, AF; Thompson, M, 1974)
" There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis."3.65Lysozymuria and acute disorders of renal function. ( De Silva, KL; Harrison, JF; Parker, RW, 1973)
"A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy."3.65Aspirin and the kidney. New Zealand Rheumatism Association Study. ( , 1974)
"Three children with the hemolytic-uremic syndrome were treated with heparin, aspirin, and dipyridamole."3.65Preliminary report: treatment of the hemolytic-uremic syndrome with aspirin and dipyridamole. ( Arenson, EB; August, CS, 1975)
"Analgesic nephropathy is part of a wider clinical syndrome associated with the abuse of APC compounds, that is, a minimum total intake of 2 kg of aspirin or phenacetin."3.65Analgesic nephropathy. ( Nanra, RS, 1976)
"In 1255 hemodialysis patients with type 2 diabetes, the German Diabetes Dialysis Study evaluated the effect of atorvastatin (20 mg/d) versus placebo."2.75Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes. ( Berger, M; Krane, V; Lilienthal, J; Schambeck, C; Wanner, C; Winkler, K, 2010)
" Documentation is derived from clinical trials, post-marketing surveillance, special studies, and spontaneous reports of adverse drug reactions from foreign countries."2.66Worldwide safety experience with diclofenac. ( Catalano, MA, 1986)
"Since its introduction in the United States in 1974, ibuprofen (Motrin, Upjohn) has been shown to be safe and effective for the treatment of pain, dysmenorrhea, inflammation, and fever."2.65Safety profile: fifteen years of clinical experience with ibuprofen. ( Royer, GL; Seckman, CE; Welshman, IR, 1984)
"Angiogenic and non-angiogenic preeclampsia are identified by a sFlt-1PlGF≥85 and<85, respectively, with the risk of maternal and fetal complications at two weeks differing between the two."2.61[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians]. ( Achiche, J; Ahriz Saksi, S; Bailleul, S; Boulanger, H; Drouin, D; Dupuis, E; Ekoukou, D; Lefèvre, G; Sault, C; Stawiarski, N, 2019)
"Second, new findings about postoperative pain management in patients with preoperative pain and chronic opioid consumption are reported."2.48Room for improvement: unmet needs in postoperative pain management. ( Pogatzki-Zahn, EM; Schnabel, A; Zahn, PK, 2012)
"The differential diagnosis of pulmonary disease should include drug toxicity, progression of the primary illness, and opportunistic infection."2.42Infiltrative lung disease due to noncytotoxic agents. ( Cooper, JA; Eggert, M; Lock, BJ, 2004)
"Normal pregnancy is characterized by a marked reduction in peripheral vascular resistance."2.40Hypertension in pregnancy. ( Bernheim, J, 1997)
" Data are presented in 46 patients who took aspirin continuously for 10 or more years (mean total dosage 35 kg) in whom there was no evidence of significant renal dysfunction."2.36Aspirin and renal disease. ( Emkey, RD, 1983)
"Few large studies have evaluated the adverse events associated with therapeutic colonoscopy for colorectal neoplasia, including bleeding and bowel perforation."1.43Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan. ( Fushimi, K; Hirata, Y; Koike, K; Matsui, H; Niikura, R; Yamada, A; Yasunaga, H, 2016)
" These results suggest that even the acute use of an NSAID (regardless of COX-2 selectivity) can induce gastric damage when combined with the long-term use of low-dose aspirin in an animal model."1.43Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy. ( Baglie, S; Baller, EM; Franco, GC; Gevert, MV; Lupepsa, AC; Moro, MG; Sanchez, PK; Tostes, AF, 2016)
"Overweight and obesity are well-established risk factors for cardiovascular disease and decline in kidney function in individuals with existing chronic kidney disease (CKD)."1.33Association between body mass index and CKD in apparently healthy men. ( Buring, JE; Gaziano, JM; Gelber, RP; Kausz, AT; Kurth, T; Levey, AS; Manson, JE, 2005)
"Dyslipidemia is associated with macular exudates and vision loss."1.32Preventing diabetic retinopathy through control of systemic factors. ( Fong, D; Jain, A; Sarraf, D, 2003)
"Polyarteritis nodosa is a difficult condition to diagnose in a child and can cause brainstem lesions."1.32Ocular tilt reaction due to a mesencephalic lesion in juvenile polyarteritis nodosa. ( Chong, WK; Dillon, MJ; Elston, J; Harris, CM; Ragge, NK; Taylor, DS, 2003)
"Severe bleeding was defined by the need for admission to hospital."1.31Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment. ( Castellino, G; Cuadrado, MJ; Godfrey, T; Hughes, GR; Khamashta, MA, 2001)
" Plasma concentrations were measured in four additional animals of all high dose groups after the last dosing at seven time points."1.29Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys. ( Bauer, E; Bauer, M; Greischel, A; Hirsch, U; Lehmann, H; Schmid, J; Schneider, P, 1996)
"Women on aspirin, who developed preeclampsia, delivered later in pregnancy [35."1.29Prevention of preeclampsia with heparin and antiplatelet drugs in women with renal disease. ( Fairley, KF; Ferrier, C; Gamble, G; Kincaid-Smith, P; North, RA, 1995)
"The incidence of nausea has increased after LAS administration."1.28Lysine acetyl salicylic acid in acute renal pain. ( Hanafi, A; Youssef, HA, 1989)
" This relationship may represent a dose-response curve relating amount of analgesic intake to prevalence of nephropathy."1.27Renal disease from habitual antipyretic analgesic consumption: an assessment of the epidemiologic evidence. ( Buckalew, VM; Schey, HM, 1986)
" Patients with this renal disorder require a permanent high dosed indomethacin therapy."1.27[The significance of renal prostaglandins for kidney function in early childhood]. ( Seyberth, HW, 1987)
"Aspirin treatment reduced PGE2 synthesis in all regions, but outer medullary PGE2 remained higher in jj (18 +/- 3) than jJ rats (9 +/- 2) (p less than 0."1.27Salicylate nephropathy in the Gunn rat: potential role of prostaglandins. ( Janis, R; Mittman, N; Schlondorff, D, 1985)
"Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels."1.26Aspirin and analgesic nephropathy. ( Emkey, RD; Mills, JA, 1982)
"In patients with preeclampsia the renal excretion of beta 2-microglobulin allows to differentiate between a primary preeclampsia and a preeclampsia superimposed upon chronic pyelonephritis."1.26Beta 2-microglobulin and other proteins as parameter for tubular function. ( Jaques, G; Keller, M; Mondorf, AW; Prüfer, D; Weise, M, 1981)
"Phenacetin was removed from this preparation in 1970 and replaced by an approximately equal amount of ASA (ACC)."1.25Letter: The clinical course of patients with analgesic nephropathy. ( Gault, MH, 1975)

Research

Studies (251)

TimeframeStudies, this research(%)All Research%
pre-1990150 (59.76)18.7374
1990's32 (12.75)18.2507
2000's37 (14.74)29.6817
2010's29 (11.55)24.3611
2020's3 (1.20)2.80

Authors

AuthorsStudies
Wang, IK1
Yen, TH1
Guo, YC1
Sun, Y1
Lien, LM1
Chang, WL1
Chen, PL1
Yang, YC1
Sung, FC1
Hsu, CY1
Diener, HC1
Sacco, RL1
Easton, JD1
Granger, CB1
Bar, M1
Bernstein, RA1
Brainin, M1
Brueckmann, M1
Cronin, L1
Donnan, G1
Gdovinová, Z1
Grauer, C1
Kleine, E1
Kleinig, TJ1
Lyrer, P1
Martins, S1
Meyerhoff, J1
Milling, T1
Pfeilschifter, W1
Poli, S1
Reif, M1
Rose, DZ1
Šaňák, D1
Schäbitz, WR1
Metkus, TS1
Qadir, MI1
Rehman, A1
HamidAkash, MS1
Irfan, M1
Baber, M1
Hussain, SB1
Asif, S2
Malik, L1
Qiu, J1
Grine, K1
Weise, FK1
Bordignon, S1
Perrotta, L1
Konstantinou, A1
Bologna, F1
Nagase, T1
Chen, S1
Chun, KRJ1
Schmidt, B1
Mudassir, S1
Toor, RS1
Boulanger, H1
Lefèvre, G1
Ahriz Saksi, S1
Achiche, J1
Bailleul, S1
Ekoukou, D1
Drouin, D1
Sault, C1
Stawiarski, N1
Dupuis, E1
Patel, MR1
Aboyans, V1
Brodmann, M1
De Carlo, M1
Clement, D1
Mazzolai, L1
van Bortel, L1
van Sambeek, MR1
Vlachopoulos, C1
Guo, LZ1
Kim, MH1
Kim, TH1
Park, JS1
Jin, E1
Shim, CH1
Choi, SY1
Serebruany, VL1
Viecelli, AK1
Pascoe, EM1
Polkinghorne, KR1
Hawley, CM1
Paul-Brent, PA1
Badve, SV1
Cass, A2
Johnson, DW1
Kerr, PG1
Mori, TA1
Scaria, A1
Hooi, LS1
Ong, LM1
Irish, AB1
Niikura, R1
Yasunaga, H1
Yamada, A1
Matsui, H1
Fushimi, K1
Hirata, Y2
Koike, K1
Bouzenna, H1
Samout, N1
Amani, E1
Mbarki, S1
Tlili, Z1
Rjeibi, I1
Elfeki, A1
Talarmin, H1
Hfaiedh, N1
Makam, RC1
Erskine, N1
McManus, DD1
Lessard, D1
Gore, JM1
Yarzebski, J1
Goldberg, RJ1
Moro, MG1
Sanchez, PK1
Gevert, MV1
Baller, EM1
Tostes, AF1
Lupepsa, AC1
Baglie, S1
Franco, GC1
Khedri, M1
Szummer, K1
Carrero, JJ1
Jernberg, T1
Evans, M1
Jacobson, SH1
Spaak, J1
Capitanini, A1
Tavolaro, A1
Rosellini, M1
Rossi, A1
Sakariassen, KS1
Alberts, P1
Fontana, P1
Mann, J1
Bounameaux, H1
Sorensen, AS1
Krane, V2
Berger, M1
Lilienthal, J1
Winkler, K1
Schambeck, C1
Wanner, C2
Uchida, Y1
Mori, F1
Ogawa, H1
Takagi, A1
Hagiwara, N1
Jardine, MJ1
Ninomiya, T1
Perkovic, V1
Turnbull, F1
Gallagher, MP1
Zoungas, S1
Lambers Heerspink, HJ1
Chalmers, J1
Zanchetti, A1
Wali, RK1
Rivera Gorrin, M1
Htun, P1
Fateh-Moghadam, S1
Bischofs, C1
Banya, W1
Müller, K1
Bigalke, B1
Stellos, K1
May, AE1
Flather, M1
Gawaz, M1
Geisler, T1
Bech, FR1
Chertow, GM1
Dixon, BS1
Beck, GJ1
Dember, LM1
Vazquez, MA1
Greenberg, A1
Delmez, JA1
Allon, M2
Himmelfarb, J1
Hu, B1
Greene, T1
Radeva, MK1
Davidson, IJ1
Ikizler, TA1
Braden, GL1
Lawson, JH1
Cotton, JR1
Kusek, JW1
Feldman, HI1
Hart, RG1
Pearce, LA1
Asinger, RW1
Herzog, CA1
Basra, SS1
Tsai, P1
Lakkis, NM1
Zhang, L1
Maya, ID1
Bray, MS1
Fernandez, JR1
Cao, L1
Silvestry, S1
Zhao, N1
Diehl, J1
Sun, J1
Pogatzki-Zahn, EM1
Schnabel, A1
Zahn, PK1
Choi, YH1
Suh, SH1
Choi, JS1
Kim, CS1
Sim, DS1
Bae, EH1
Lim, SY1
Ma, SK1
Jeong, MH1
Kim, SW1
Wong, F1
Guignard, JP1
Ragge, NK1
Harris, CM1
Dillon, MJ1
Chong, WK1
Elston, J1
Taylor, DS1
Fernandez, JS1
Sadaniantz, BT1
Sadaniantz, A1
HEDWALL, P1
HEEG, E1
SCOTT, JT3
DENMAN, AM1
DORLING, J1
CLAUSEN, E2
STERN, FH1
GILMAN, A1
MCGUINNESS, BW1
DAWBORN, JK1
KINCAID-SMITH, P4
MCLAREN, J1
RAMSAY, AG1
WHITE, DF1
LABRAM, C1
YOUNG, JV1
HAYDON, GB1
GRAY, CP1
HECKER, SP1
LEE, PR1
GILES, HM1
Jain, A1
Sarraf, D1
Fong, D1
Brandt, K1
Lock, BJ1
Eggert, M1
Cooper, JA1
Baigent, C1
Landray, M1
Leaper, C1
Altmann, P1
Armitage, J1
Baxter, A1
Cairns, HS1
Collins, R1
Foley, RN1
Frighi, V1
Kourellias, K1
Ratcliffe, PJ1
Rogerson, M1
Scoble, JE1
Tomson, CR1
Warwick, G1
Wheeler, DC1
Yamamoto, K1
Yasunaga, Y1
McQueen, MJ1
Lonn, E1
Gerstein, HC1
Bosch, J1
Yusuf, S1
Gelber, RP2
Kurth, T2
Kausz, AT1
Manson, JE1
Buring, JE1
Levey, AS1
Gaziano, JM2
Xu, S1
Jiang, B1
Maitland, KA1
Bayat, H1
Gu, J1
Nadler, JL1
Corda, S1
Lavielle, G1
Verbeuren, TJ1
Zuccollo, A1
Cohen, RA1
McAlister, FA1
Ghali, WA1
Gong, Y1
Fang, J1
Armstrong, PW1
Tu, JV1
Otrock, ZK1
Sawaya, JI1
Zebian, RC1
Taher, AT1
Bertagnolli, MM1
Eagle, CJ2
Zauber, AG2
Redston, M1
Solomon, SD2
Kim, K1
Tang, J2
Rosenstein, RB2
Wittes, J2
Corle, D1
Hess, TM1
Woloj, GM1
Boisserie, F1
Anderson, WF1
Viner, JL1
Bagheri, D1
Burn, J1
Chung, DC1
Dewar, T1
Foley, TR1
Hoffman, N1
Macrae, F1
Pruitt, RE1
Saltzman, JR1
Salzberg, B1
Sylwestrowicz, T1
Gordon, GB1
Hawk, ET1
Arber, N1
Spicak, J1
Rácz, I1
Dite, P1
Hajer, J1
Zavoral, M1
Lechuga, MJ1
Gerletti, P1
Macdonald, K1
Bhadra, P1
Fowler, R1
Levin, B1
Chaussade, S1
Avouac, B1
Vicaut, E1
Valat, JP1
Garcia-Donaire, JA1
Ruilope, LM1
de Silva, R1
Nikitin, NP1
Witte, KK1
Rigby, AS1
Loh, H1
Nicholson, A1
Bhandari, S1
Clark, AL1
Cleland, JG1
Sedlacek, M1
Gemery, JM1
Cheung, AL1
Bayer, AS1
Remillard, BD1
Vadivel, N1
Trikudanathan, S1
Singh, AK1
Schaeffner, ES1
Bowman, TS1
Sweileh, WM1
Agodoa, LY1
Francis, ME1
Eggers, PW1
Belibasakis, I1
Mazaris, E1
Papachristou, C1
Kastriotis, I1
Weise, M1
Prüfer, D1
Jaques, G1
Keller, M1
Mondorf, AW1
Royer, GL1
Seckman, CE1
Welshman, IR1
Cinotti, GA1
Emkey, RD2
Hanks, GW1
Clive, DM1
Stoff, JS1
Foley, RJ1
Weinman, EJ1
Arroyo, V1
Planas, R1
Gaya, J1
Deulofeu, R1
Rimola, A1
Pérez-Ayuso, RM1
Rivera, F1
Rodés, J1
Magrini, M1
Pavesi, G1
Liverta, C1
Bruni, G1
Hornych, A1
Vítko, S1
Prát, V1
Matousovic, K1
Dráb, K1
Horcicková, M1
Ehrlich, G1
Plaza de los Reyes, M1
Lazcano, F1
Passalacqua, W1
Plaza de los Reyes, X1
Saffie, A1
de Croizet, V1
Morin, RJ1
Chen, AF1
Narayanan, AS1
Raye, C1
Moss, RA1
Srikantaiah, MV1
Barajas, L1
Axelsen, RA1
Henry, MA1
Sweet, RS1
Tange, JD2
Dewanjee, MK1
Fuster, V1
Rao, SA1
Forshaw, PL1
Kaye, MP1
Nielsen, IL2
Rasmussen, S2
Petersen, J1
Christensen, P1
Hilden, T2
Birgens, HS1
Hansen, MS1
Duggin, GG2
Mills, JA1
Gall, EP1
Vanherweghem, JL1
Even-Adin, D1
Mikulaschek, WM1
Briggs, D1
Calder, I1
Woods, R1
Tange, J1
Eisinger, AJ1
Harbison, RD1
Oudart, N1
Marcher, K1
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Guichard, C1
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Matzke, GR2
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Testa, A1
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Grolleau, JY1
Beaufils, M1
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Adams, KE1
Brown, PA1
Heys, SD1
Whiting, PH1
De Santo, NG1
Calò, L1
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Cantaro, S1
Favaro, S1
Capasso, G1
Borsatti, A1
Henrich, WL1
Agodoa, LE1
Barrett, B1
Bennett, WM1
Blantz, RC1
Buckalew, VM3
D'Agati, VD1
DeBroe, ME1
Eknoyan, G2
Lipton, RB1
Raskin, N1
Ruoff, G1
Saper, J1
Sheftell, F1
Solomon, S1
Winchester, JF1
North, RA1
Ferrier, C1
Gamble, G1
Fairley, KF1
Lehmann, H1
Hirsch, U1
Bauer, E1
Bauer, M1
Greischel, A1
Schmid, J1
Schneider, P1
Leslie, GI1
Gallery, ED2
Arnold, JD1
Ross, MR1
Gyory, AZ1
al-Sahlawi, KS1
Tawfik, OM1
McGoldrick, MD1
Bailie, GR1
Delzell, E1
Shapiro, S1
Bernheim, J1
Birbari, AE1
Villar, D1
Buck, WB1
Gonzalez, JM1
Oshima, T1
Baumeister, M1
Aicher, B1
Lornoy, W1
Becaus, I1
Billiouw, JM1
Sierens, L1
van Kleef, EM1
Te Poele, JA1
Oussoren, YG1
van der Wal, A1
Dewit, LG1
Murphy, GJ1
Taha, R1
Windmill, DC1
Metcalfe, M1
Nicholson, ML1
Castellino, G1
Cuadrado, MJ1
Godfrey, T1
Khamashta, MA1
Hughes, GR1
Muller, DN1
Heissmeyer, V1
Dechend, R1
Hampich, F1
Park, JK1
Fiebeler, A1
Shagdarsuren, E1
Theuer, J1
Elger, M1
Pilz, B1
Breu, V1
Schroer, K1
Ganten, D1
Dietz, R1
Haller, H1
Scheidereit, C1
Luft, FC1
Aitio, ML1
Nakamura, H1
Maharaj, R1
Campo, A1
Mathew, TH1
Boss, GR1
Seegmiller, JE1
George, CR2
Clark, WF1
Cameron, JS1
Emmerson, BT1
Proctor, RA1
Kunin, CM1
Heel, RC1
Brogden, RN1
Speight, TM1
Avery, GS1
Nanra, RS3
Stuart-Taylor, J1
de Leon, AH1
White, KH1
Breddin, K1
Dieppe, PA2
Huskisson, EC1
Prescott, LF1
Schreiner, GE1
Gault, MH5
Wilson, DR2
Murray, TG1
Goldberg, M2
Berio, A1
Harker, LA2
Hirsh, J1
Gent, M1
Genton, E1
Kennedy, A2
Weiss, HJ1
Mokotoff, DM1
Burns, C1
Molland, EA1
Christie, D1
McPherson, L1
Fossati, C1
Phillips, BM1
Hartnagel, RE1
Leeling, JL1
Gurtoo, HL1
Stewart, JH2
McCarthy, SW1
Storey, BG1
Roberts, BA1
Gallery, E1
Mahony, JF1
Goldberger, LE1
Talner, LB1
Arenson, EB1
August, CS1
McIver, MA1
Parker, RW2
Shaw, RE1
Kramer, P1
Adams, FG1
Murray, RM5
Naess, K2
Greene, JM1
Winickoff, RN1
Naruse, T1
Burrell, JH2
Yong, JL2
Macdonald, GJ2
Dubach, UC3
Rosner, B1
Stürmer, T1
Shichiri, M1
Itoh, H1
Iwamoto, H1
Marumo, F1
Knorr, PA1
Woodside, JR1
Ruiz, H1
Saltzman, B1
Zoja, C1
Benigni, A1
Livio, M1
Bergamelli, A1
Orisio, S1
Abbate, M1
Bertani, T1
Remuzzi, G1
Youssef, HA1
Hanafi, A1
Sandler, DP1
Smith, JC1
Weinberg, CR1
Dennis, VW1
Blythe, WB1
Burgess, WP1
Schwarz, A1
Kunzendorf, U1
Keller, F1
Offermann, G1
Schlegel, SI1
Paulus, HE1
Ehrich, JH1
Wurster, U1
Lütge, M1
Doehring, E1
Oemar, B1
Hackenthal, E1
Schey, HM1
Catalano, MA1
Seyberth, HW1
Mittman, N1
Janis, R1
Schlondorff, D1
Grzesik, J1
Rzymełka, S1
Uppington, J1
Jobin, F1
DeLage, JM1
Timbury, GC1
Linton, AL1
Ohela, K1
Ahonen, A1
Nakano, J1
Wainscoat, JS1
Finn, R1
Gilchrist, GS1
Bailey, RR1
Neale, TJ1
Little, PJ1
Gross, A1
Girard, V1
Slichter, SJ1
Quadracci, LJ1
Striker, GE1
Rosenmann, E1
Dishon, T1
Boss, JH1
Harrison, JF1
De Silva, KL1
Petrin, A1
Schmidt, R1
Burry, HC1
Macklon, AF1
Craft, AW1
Thompson, M1
Kerr, DN1
Klinenberg, JR2
Bluestone, R1
Campion, D1
Whitehouse, M1
Ramsdell, CM1
Kelley, WN1
Vivaldi, E1
Wigley, RD1
Champion, GD1
Edwards, KD2
Schapel, GJ1
Jeremy, R1
Steele, TW1
Calder, IC1
Funder, CC1
Green, CR1
Ham, KN1
Barrientos Guzmám, A1
Rivas Manga, MC1
Llamazares Ortega, C1
Hernando Avendaño, L1
Bakke, OM1
Cammeo, F1
Curtis, EA1
Stoker, LM1
Dalessio, DJ1
Rudwal, TC2
Redmond, NI1
Pinals, RS1
Kippen, I1
Saluga, PG1
Abel, JA1
Miley, RA1
Heidland, A1
Klütsch, K1
Spall, M1
Frohwein, H1
Engles, WD1
Dossetor, JB1
Jensen, K1
Bluemle, LW1
Grögler, F1
Páramo, PG1
Resel, L1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-blind, Evaluation in Secondary Stroke Prevention Comparing the EfficaCy and Safety of the Oral Thrombin Inhibitor Dabigatran Etexilate (110 mg or 150 mg, Oral b.i.d.) Versus Acetylsalicylic Acid (100 mg Oral q.d.) in Patients With Embol[NCT02239120]Phase 35,390 participants (Actual)Interventional2014-11-27Completed
RENal Hemodialysis Patients ALlocated Apixaban Versus Warfarin in Atrial Fibrillation (RENAL-AF) Randomized Clinical Trial[NCT02942407]Phase 4154 participants (Actual)Interventional2016-12-31Completed
Evaluation of Platelet Aggregation and Adenosine Levels in Patients With Coronary Artery Disease and Chronic Kidney Dysfunction Taking Dual Antiplatelet Therapy With Aspirin and Clopidogrel or Ticagrelor[NCT03039205]Phase 290 participants (Actual)Interventional2017-11-07Completed
Effects of Pulsatile IV Insulin Delivery on Diabetic Retinopathy[NCT00287651]Phase 2/Phase 3150 participants (Actual)Interventional2005-11-30Terminated (stopped due to Administrative)
Study of Heart and Renal Protection (SHARP): The Effects of Lowering LDL-cholesterol With Simvastatin 20mg Plus Ezetimibe 10mg in Patients With Chronic Kidney Disease: a Randomized Placebo-controlled Trial[NCT00125593]Phase 49,438 participants (Actual)Interventional2003-06-30Completed
Prevention of Sporadic Colorectal Adenomas With Celecoxib[NCT00005094]Phase 31,170 participants (Anticipated)Interventional2000-03-31Completed
Celecoxib for the Treatment of Non-muscle Invasive Bladder Cancer[NCT02343614]Phase 258 participants (Actual)Interventional2003-03-31Completed
Clinical Protocol For a Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Celecoxib (SC-58635) In The Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP)[NCT00141193]Phase 31,561 participants (Actual)Interventional2001-02-28Completed
[NCT00000151]Phase 30 participants Interventional1979-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Adjudicated Composite of Non-fatal Stroke, Non-fatal Myocardial Infarction, or Cardiovascular Death

Adjudicated composite of non-fatal stroke, non-fatal myocardial infarction (MI), or cardiovascular death is a key secondary endpoint. The annualised event rate represents the average number of events per patient during a 1-year period. (NCT02239120)
Timeframe: From randomisation until full follow up period, up to 43 months

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)4.80
Acetylsalicylic Acid, Aspirin (ASA) 100 mg5.40

Adjudicated Fatal Bleed

Adjudicated fatal bleeding was defined as a bleeding event which the Independent Event Adjudication Committee (IAC) determined as the primary cause of death or contributed directly to death. The annualised event rate represents the average number of events per patient during a 1-year period. Because there were 0 events in one treatment group, the hazard ratio is unable to be calculated. (NCT02239120)
Timeframe: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)0.00
Acetylsalicylic Acid, Aspirin (ASA) 100 mg0.05

Adjudicated Intracranial Hemorrhage

"Adjudicated intracranial haemorrhage comprised the subtypes of intracerebral bleeds, intraventricular bleeds, subdural bleeds, epidural bleeds, and subarachnoid bleeds. Microbleeds did not qualify as intracranial haemorrhage, except when they were symptomatic.~The annualised event rate represents the average number of events per patient during a 1-year period." (NCT02239120)
Timeframe: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)0.67
Acetylsalicylic Acid, Aspirin (ASA) 100 mg0.63

Adjudicated Ischaemic Stroke

Adjudicated ischaemic stroke is a key secondary endpoint. The annualised event rate represents the average number of events per patient during a 1-year period. (NCT02239120)
Timeframe: From randomisation until full follow up period, up to 43 months

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)3.97
Acetylsalicylic Acid, Aspirin (ASA) 100 mg4.71

Adjudicated Life-threatening Bleed

"Major bleeds were to be classified as life-threatening if they met one or more of the following criteria: fatal bleed, symptomatic intracranial bleed, reduction in haemoglobin of at least 5 grams/ deciliter (g/dL), transfusion of at least 4 units of packed red blood cells (equivalent to 9 units in Japan), associated with hypotension requiring the use of intravenous inotropic agents, or necessitated surgical intervention.~The annualised event rate represents the average number of events per patient during a 1-year period." (NCT02239120)
Timeframe: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)0.76
Acetylsalicylic Acid, Aspirin (ASA) 100 mg0.91

Adjudicated Recurrent Stroke

Adjudicated recurrent stroke (ischemic, hemorrhagic, or unspecified) is presented. The annualised event rate represents the average number of events per patient during a 1-year period. (NCT02239120)
Timeframe: From randomisation until full follow up period, approximately 43 months.

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)4.09
Acetylsalicylic Acid, Aspirin (ASA) 100 mg4.80

All-cause Death

All-cause death is presented. The annualised event rate represents the average number of events per patient during a 1-year period. (NCT02239120)
Timeframe: From randomisation until full follow up period, up to 43 months

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)1.24
Acetylsalicylic Acid, Aspirin (ASA) 100 mg1.28

Any Bleed (Investigator-reported)

"This was the sum of all major and minor bleeds (Minor bleeds were clinical bleeds that did not fulfil the criteria for major bleeds), regardless of severity.~The annualised event rate represents the average number of events per patient during a 1-year period." (NCT02239120)
Timeframe: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)15.21
Acetylsalicylic Acid, Aspirin (ASA) 100 mg11.64

Disabling Stroke

Disabling stroke (modified Rankin Scale greater than or equal to 4, as determined 3 months after recurrent stroke) is presented. The annualised event rate represents the average number of events per patient during a 1-year period. (NCT02239120)
Timeframe: From randomisation until full follow up period, up to 43 months

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)0.55
Acetylsalicylic Acid, Aspirin (ASA) 100 mg0.93

First Major Bleed (Adjudicated)

"First major bleed is primary safety endpoint. Major bleeds were defined according to the International Society of Thrombosis and Haemostasis (ISTH) definition as follows:~Symptomatic bleeding in a critical area or organ, such as intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, or intramuscular with compartment syndrome and/or,~Bleeding (which should be overt) associated with a reduction in haemoglobin of at least 2 grams/ decilitre (g/dL) (1.24 millimoles Per Litre (mmol/L)), or leading to transfusion of ≥2 units of blood or packed cells (equivalent to ≥4.5 units in Japan); the haemoglobin drop should be considered to be due to and temporally related to the bleeding event and/or,~Fatal bleed. The annualised event rate represents the average number of events per patient during a 1-year period." (NCT02239120)
Timeframe: Between the first trial medication intake up to 6 days after the last trial medication intake, approximately 42 months.

InterventionAnnualised event rate (%/ year) (Number)
Dabigatran Etexilate 110 or 150 Milligram (mg)1.84
Acetylsalicylic Acid, Aspirin (ASA) 100 mg1.33

Apixaban Plasma Concentration, Cmax

Evaluate the pharmacokinetics of apixaban in ESRD NVAF patients on hemodialysis. The measurement was done from 0-12 hours after the dose was given on Day 1. (NCT02942407)
Timeframe: 0-12 hours post-dose

Interventionng/mL (Geometric Mean)
Apixaban 2.5 mg59.7
Apixaban 5 mg97.9

Apixaban Plasma Concentration, Cmin

Evaluate the pharmacokinetics of apixaban in ESRD NVAF patients on hemodialysis. The measurement was done from 0-12 hours after the dose was given on Day 1. (NCT02942407)
Timeframe: 0-12 hours post-dose

Interventionng/mL (Geometric Mean)
Apixaban 2.5 mg28.2
Apixaban 5mg49.7

Area Under the Plasma Apixaban Concentration Curve From 0 to 12 Hours After Dose (AUCO-12)

Evaluate the pharmacokinetics of apixaban in ESRD NVAF patients on hemodialysis. The measurement was done from 0 to 12 hours after dose was given on Day 1. (NCT02942407)
Timeframe: 0-12 hours post-dose

Interventionng*h/mL (Geometric Mean)
Apixaban 2.5 mg507
Apixaban 5mg868

Number of Participants Experiencing ISTH (International Society on Thrombosis and Haemostasis) Major or Clinically Relevant Non-major Bleeding

"Assess the safety of apixaban versus warfarin regarding ISTH major bleeding or clinically relevant non-major bleeding events in patients with NVAF (nonvalvular atrial fibrillation) and ESRD (end-stage renal disease) on hemodialysis.~Major bleeding event is defined as:Acute clinically overt bleeding (including access site related bleeding) accompanied by 1 or more of the following: Decrease in Hgb of 2g/dL or more with overt bleeding; Transfusion of 2 or more units of packed RBCs in the setting of an overt bleeding event; Bleeding within a critical site. Hemorrhagic stroke (primary or infarction with hemorrhagic conversion) were classified as major bleeds.~Non-major bleeding event is defined as: Acute or sub-acute clinically overt bleeding (including access site related bleeding) that does not meet criteria for major bleeding & results in Hospital admission for bleeding, physician guided medical or surgical treatment for bleeding, or change in antithrombotic therapy" (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionParticipants (Count of Participants)
Apixaban21
Warfarin16

Number of Participants Experiencing Mortality

Evaluate mortality rates for those participants randomized to warfarin and apixaban in patients with NVAF and ESRD on hemodialysis (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionParticipants (Count of Participants)
Apixaban21
Warfarin13

Number of Participants Experiencing Stroke

"Adjudcated stroke defined as a new, non-traumatic episode of focal or global neurological dysfunction of sudden onset caused by central nervous system (CNS) vascular injury as a result of hemorrhage or infarction and not due to a readily identifiable non-vascular cause (i.e. brain tumor). CNS includes brain, spinal cord and retina. The required duration of the deficit is ≥ 24 hours.~Events with neurologic deficit lasting for < 24 hours and an imaging modality showing evidence of an acute stroke will be counted as stroke as well.~A retinal ischemic event (embolism, infarction) will be considered a stroke" (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionParticipants (Count of Participants)
Apixaban2
Warfarin2

Number of Participants Experiencing Stroke or Systemic Embolism

Number of participants experiencing adjudicated stroke or systemic embolism. (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionParticipants (Count of Participants)
Apixaban2
Warfarin2

Number of Participants Experiencing Stroke, Systemic Embolism, Major Bleeding or All-cause Mortality

"Evaluate those experiencing stroke, systemic embolism, ISTH major bleeding, or all-cause mortality for those randomized to warfarin and apixaban in patients with NVAF and ESRD on hemodialysis~Definitions of stroke and systemic embolism are provided under the measurement description of the secondary outcomes for each individual event. Definition of major bleed is provided in outcome measurement description of the primary outcome measure." (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionParticipants (Count of Participants)
Apixaban27
Warfarin29

Number of Participants Experiencing Systemic Embolism

"Adjudicated diagnosis of systemic arterial embolism (Non-pulmonary, non-cranial events) will require a positive clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), which is supported by evidence of embolism/thrombosis from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.~Clinical presentation would include:~Abrupt development of pain, absent pulses, pallor, and/or paresis in an extremity (at least an entire digit) without previous severe claudication or findings of severe peripheral vascular disease.~Renal embolism will be diagnosed when sudden flank pain or a change in renal laboratory findings occurred.~Abdominal vascular/visceral embolism was considered definite if acute abdominal symptoms or referred symptoms developed along with a change in abdominal examination or appropriate laboratory values." (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionParticipants (Count of Participants)
Apixaban0
Warfarin0

Persistence of Therapy

Evaluate days between time from initiation to discontinuation of randomized therapy. (NCT02942407)
Timeframe: Randomization up to Month 15/Final Visit

InterventionDays (Mean)
Apixaban304.4
Warfarin279.6

Coronary or Non-coronary Revascularization Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Revascularization included any arterial revascularization procedure, whether surgical or percutaneous, but excluded revascularization performed for hemodialysis vascular access (e.g. fistuloplasty) or to the donor kidney transplant artery. Revascularization included amputations for vascular disease (rather than for trauma or infection). All potential revascularization events (including angiography) were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe284
Placebo352

End-stage Renal Disease Among All Patients Not on Dialysis at the Time of Randomization to Simvastatin Plus Ezetimibe Versus Placebo

End-stage renal disease was defined as initiation of maintenance dialysis or renal transplantation. Temporary dialysis was excluded. All potential dialysis and transplant events were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe1057
Placebo1084

Key Outcome as Per Statistical Analysis Plan = Major Atherosclerotic Events Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Major atherosclerotic events defined as non-fatal myocardial infarction or coronary death, non-hemorrhagic stroke, or any arterial revascularization procedure (excluding dialysis access procedures). Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe526
Placebo619

Major Coronary Events Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Major coronary events defined as coronary death or non-fatal myocardial infarction. Myocardial infarction adjudicated based on the presence of serial changes in cardiac biomarkers (e.g. troponin, creatine kinase), typical ECG changes and typical cardiac symptoms. If myocardial infarction was fatal and post-mortem examination findings were available, this information was also assessed. All potential coronary events were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe213
Placebo230

Major Vascular Events Analyzed Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Major vascular events defined as non-fatal myocardial infarction or cardiac death, any stroke, or any arterial revascularization procedure (excluding dialysis access procedures). Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe701
Placebo814

Major Vascular Events Analyzed Amongst Patients Initially Randomized to Simvastatin Plus Ezetimibe Versus Placebo (Original Protocol-defined Primary Outcome)

Major vascular events defined as non-fatal myocardial infarction or cardiac death, any stroke, or any arterial revascularization procedure (excluding dialysis access procedures). Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe639
Placebo749

Non-hemorrhagic Stroke Among All of Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Stroke was defined as rapid onset of focal or global neurological deficit, with duration greater than 24 hours. Clinical notes and brain imaging were sought to determine the stroke etiology, and if the stroke was fatal and post-mortem examination findings were available, this information was also assessed. All potential stroke events (including transient ischemic attack and intracerebral hemorrhage) were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Interventionparticipants (Number)
Simvastatin Plus Ezetimibe131
Placebo174

Reviews

42 reviews available for aspirin and Kidney Diseases

ArticleYear
[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians].
    Nephrologie & therapeutique, 2019, Volume: 15, Issue:6

    Topics: Adult; Aspirin; Biomarkers; Endoglin; Endothelium, Vascular; Female; Humans; Immune Tolerance; Infla

2019
The year in cardiology 2014: peripheral circulation.
    European heart journal, 2015, Mar-07, Volume: 36, Issue:10

    Topics: Anticoagulants; Aortic Aneurysm, Abdominal; Aspirin; Biomarkers; Carotid Artery Diseases; Endovascul

2015
Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.
    Future cardiology, 2009, Volume: 5, Issue:5

    Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Humans;

2009
Safety and efficacy of antiplatelet and antithrombotic therapy in acute coronary syndrome patients with chronic kidney disease.
    Journal of the American College of Cardiology, 2011, Nov-22, Volume: 58, Issue:22

    Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chronic Disease; Clinical Trials as Topic; Clopidogrel;

2011
Room for improvement: unmet needs in postoperative pain management.
    Expert review of neurotherapeutics, 2012, Volume: 12, Issue:5

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases;

2012
Liver and kidney diseases.
    Clinics in liver disease, 2002, Volume: 6, Issue:4

    Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G

2002
Review of antithrombotic agents used for acute coronary syndromes in renal patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:3

    Topics: Acute Disease; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Fib

2003
[Paracetamol in the treatment of osteoarthritis pain].
    Drugs, 2003, Volume: 63 Spec No 2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg

2003
Infiltrative lung disease due to noncytotoxic agents.
    Clinics in chest medicine, 2004, Volume: 25, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Aspirin; Humans; Hydrochlorothiazide;

2004
[What is the impact of cardiovascular and renal complications on the benefit/risk ratio of the NSAIDs?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Contro

2006
Spotlight on renin: cardiovascular outcomes in chronic kidney disease and suppression of the renin-angiotensin system.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2006, Volume: 7, Issue:1

    Topics: Albuminuria; Aspirin; Cardiovascular Diseases; Chronic Disease; Glomerular Filtration Rate; Humans;

2006
Aspirin and renal disease.
    The American journal of medicine, 1983, Jun-14, Volume: 74, Issue:6A

    Topics: Acetaminophen; Aspirin; Drug Synergism; Humans; Kidney Diseases; Time Factors

1983
Nonprescription analgesics.
    Clinical therapeutics, 1983, Volume: 5 Suppl B

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj

1983
Renal syndromes associated with nonsteroidal antiinflammatory drugs.
    The New England journal of medicine, 1984, Mar-01, Volume: 310, Issue:9

    Topics: Acute Kidney Injury; Adult; Animals; Anti-Inflammatory Agents; Anuria; Aspirin; Body Water; Electrol

1984
Urate nephropathy.
    The American journal of the medical sciences, 1984, Volume: 288, Issue:5

    Topics: Allopurinol; Arthritis; Aspirin; Blood Urea Nitrogen; Glomerular Filtration Rate; Gout; Humans; Kidn

1984
Role of prostaglandins in drug nephrotoxicity.
    Contributions to nephrology, 1984, Volume: 42

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitor

1984
[Prevention of thrombosis by thrombocyte inhibition. 2. Clinical results].
    Ugeskrift for laeger, 1980, Jan-28, Volume: 142, Issue:5

    Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Cerebrovascular Disorders; Clofibrate; Dextrans;

1980
Mechanisms in the development of analgesic nephropathy.
    Kidney international, 1980, Volume: 18, Issue:5

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Synergism; Humans; Ki

1980
[Pregnancy nephropathies].
    Presse medicale (Paris, France : 1983), 1993, Dec-04, Volume: 22, Issue:38

    Topics: Adult; Antihypertensive Agents; Aspirin; Epoprostenol; Female; Hemostasis; Humans; Hypertension; Kid

1993
Therapeutic uses of aspirin in renal diseases.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:1 Suppl 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Kidney Diseases; Platelet Aggrega

1996
Nonnarcotic analgesics: prevalence and estimated economic impact of toxicities.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical

1997
Hypertension in pregnancy.
    Nephron, 1997, Volume: 76, Issue:3

    Topics: Adult; Animals; Antihypertensive Agents; Aspirin; Disease Models, Animal; Eclampsia; Endothelium, Va

1997
Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1998
[Analgesics and kidney].
    Duodecim; laaketieteellinen aikakauskirja, 1998, Volume: 114, Issue:9

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibito

1998
[Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Colo

2001
Do acetylsalicylic acid and other antiplatelet drugs prevent preeclampsia?
    Canadian family physician Medecin de famille canadien, 2001, Volume: 47

    Topics: Aspirin; Autoimmune Diseases; Clinical Trials as Topic; Diabetes Complications; Dose-Response Relati

2001
Hyperuricemia and gout. Classification, complications and management.
    The New England journal of medicine, 1979, Jun-28, Volume: 300, Issue:26

    Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human

1979
The role of platelets in glomerulonephritis.
    Advances in nephrology from the Necker Hospital, 1975, Volume: 5

    Topics: Adenosine; Antidepressive Agents; Aspirin; Blood Platelets; Complement System Proteins; Endothelium;

1975
Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia.
    Drugs, 1977, Volume: 14, Issue:5

    Topics: Aspirin; Benzbromarone; Benzofurans; Drug Interactions; Fasting; Gout; Humans; Kidney Diseases; Kine

1977
Analgesic nephropathy: etiology, clinical syndrome, and clinicopathologic correlations in Australia.
    Kidney international, 1978, Volume: 13, Issue:1

    Topics: Adult; Age Factors; Aged; Analgesics; Animals; Aspirin; Australia; Caffeine; Drug Combinations; Fema

1978
Use of platelet inhibitor drugs in peripheral and cerebral vascular disorders.
    Bibliotheca haematologica, 1977, Volume: 44

    Topics: Arterial Occlusive Diseases; Aspirin; Blood Platelets; Brain Ischemia; Cell Survival; Clinical Trial

1977
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
    British journal of clinical pharmacology, 1979, Volume: 7, Issue:5

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj

1979
Critical evaluation of platelet-inhibiting drugs in thrombotic disease.
    Progress in hematology, 1975, Volume: 9

    Topics: Arteriosclerosis; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical Trials as Topic; Clo

1975
Analgesic nephropathy.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9

    Topics: Acute Kidney Injury; Analgesics; Animals; Arthritis, Rheumatoid; Aspirin; Drug Combinations; Female;

1975
Antiplatelet drugs-a new pharmacologic approach to the prevention of thrombosis.
    American heart journal, 1976, Volume: 92, Issue:1

    Topics: Anticoagulants; Aspirin; Blood Platelets; Brain; Clofibrate; Dextrans; Dipyridamole; Humans; Ischemi

1976
Analgesic abuse syndrome: a frequently overlooked cause of reversible renal failure.
    Urology, 1975, Volume: 5, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Diagnosis, Differential; Dr

1975
Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis. A review and suggestions.
    Archives of internal medicine, 1992, Volume: 152, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Aspirin; Clinical Prot

1992
Non-steroidal and analgesic therapy in the elderly.
    Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen

1986
[Ototoxic factors requiring consideration in the diagnosis of occupational hearing loss].
    Medycyna pracy, 1985, Volume: 36, Issue:2

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Aspirin; Bacterial Infections; Carbon Disulfide; Carbo

1985
The prostaglandins: their significance in clinical practice.
    Medical times, 1974, Volume: 102, Issue:12

    Topics: Abortion, Induced; Anemia, Hemolytic; Animals; Aspirin; Asthma; Chemical Phenomena; Chemistry; Cycli

1974
Chronic effect of analgesics on the kidney.
    Progress in biochemical pharmacology, 1972, Volume: 7

    Topics: Aminopyrine; Analgesics; Animals; Antipyrine; Aspirin; Caffeine; Chronic Disease; Drug Combinations;

1972
Aspirin and the kidney.
    The New Zealand medical journal, 1971, Volume: 74, Issue:474

    Topics: Acetaminophen; Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Diseases; Kidney Papillary Nec

1971

Trials

25 trials available for aspirin and Kidney Diseases

ArticleYear
Antithrombotic Treatment of Embolic Stroke of Undetermined Source: RE-SPECT ESUS Elderly and Renally Impaired Subgroups.
    Stroke, 2020, Volume: 51, Issue:6

    Topics: Aged; Aged, 80 and over; Aspirin; Dabigatran; Double-Blind Method; Female; Fibrinolytic Agents; Huma

2020
Antibodies to platelet factor 4-heparin complex and outcome in hemodialysis patients with diabetes.
    Clinical journal of the American Society of Nephrology : CJASN, 2010, Volume: 5, Issue:5

    Topics: Aged; Antibodies; Aspirin; Atorvastatin; Cause of Death; Chi-Square Distribution; Death, Sudden; Dia

2010
Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial.
    Journal of the American College of Cardiology, 2010, Sep-14, Volume: 56, Issue:12

    Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Chronic Disease; Creatinine; Female; Glom

2010
Use of aspirin associates with longer primary patency of hemodialysis grafts.
    Journal of the American Society of Nephrology : JASN, 2011, Volume: 22, Issue:4

    Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Aspirin; Aspirin, Dipyridamole Drug Combination; Chronic

2011
Warfarin in atrial fibrillation patients with moderate chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:11

    Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Blood Coagulation; Canada; Chi-Square Distributi

2011
Association of factor V gene polymorphism with arteriovenous graft failure.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2012, Volume: 59, Issue:5

    Topics: Adult; Aged; Aspirin; Chronic Disease; Dipyridamole; DNA; Double-Blind Method; Factor V; Female; Fol

2012
Triple vs. dual antiplatelet therapy in patients with acute myocardial infarction and renal dysfunction.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:10

    Topics: Aged; Aged, 80 and over; Aspirin; Cilostazol; Clopidogrel; Disease-Free Survival; Drug Therapy, Comb

2012
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3

    Topics: Adult; Aged; Alanine Transaminase; Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Chronic Disea

2005
The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 2005, Volume: 240

    Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cost-Benefit Analysis; Diabetes Complications; Fe

2005
Celecoxib for the prevention of sporadic colorectal adenomas.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas

2006
Celecoxib for the prevention of sporadic colorectal adenomas.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas

2006
Celecoxib for the prevention of sporadic colorectal adenomas.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas

2006
Celecoxib for the prevention of sporadic colorectal adenomas.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas

2006
Celecoxib for the prevention of colorectal adenomatous polyps.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal

2006
Celecoxib for the prevention of colorectal adenomatous polyps.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal

2006
Celecoxib for the prevention of colorectal adenomatous polyps.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal

2006
Celecoxib for the prevention of colorectal adenomatous polyps.
    The New England journal of medicine, 2006, Aug-31, Volume: 355, Issue:9

    Topics: Adenoma; Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal

2006
Blood pressure measures and risk of chronic kidney disease in men.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aspirin; beta Carotene; Blood Pressure; Blood

2008
Potential adverse effects of a low-dose aspirin-diuretic combination on kidney function.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:11

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cross-S

2007
Safety profile: fifteen years of clinical experience with ibuprofen.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Aspirin; Blood Cell Count; Blood Coagulation Tests; Blood Proteins; Centra

1984
Intravenous ketoprofen in renal colic: a placebo-controlled pilot study.
    Clinical therapeutics, 1984, Volume: 6, Issue:4

    Topics: Adult; Aged; Analgesics; Aspirin; Clinical Trials as Topic; Colic; Female; Humans; Ketoprofen; Kidne

1984
Neonatal outcome in a randomized, controlled trial of low-dose aspirin in high-risk pregnancies.
    Journal of paediatrics and child health, 1995, Volume: 31, Issue:6

    Topics: Aspirin; Chronic Disease; Double-Blind Method; Female; Humans; Hypertension; Infant, Newborn; Kidney

1995
Comparative study of the efficacy of lysine acetylsalicylate, indomethacin and pethidine in acute renal colic.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 1996, Volume: 3, Issue:3

    Topics: Adult; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colic; Doub

1996
Use of platelet inhibitor drugs in peripheral and cerebral vascular disorders.
    Bibliotheca haematologica, 1977, Volume: 44

    Topics: Arterial Occlusive Diseases; Aspirin; Blood Platelets; Brain Ischemia; Cell Survival; Clinical Trial

1977
Diflunisal and aspirin: a comparison of efficacy and nephrotoxicity in osteoarthritis.
    Rheumatology and rehabilitation, 1979, Volume: 18, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blin

1979
Critical evaluation of platelet-inhibiting drugs in thrombotic disease.
    Progress in hematology, 1975, Volume: 9

    Topics: Arteriosclerosis; Aspirin; Blood Platelets; Cerebrovascular Disorders; Clinical Trials as Topic; Clo

1975
Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS Investigators.
    JAMA, 1992, Sep-09, Volume: 268, Issue:10

    Topics: Adolescent; Adult; Aged; Aspirin; Cerebrovascular Disorders; Diabetes Mellitus; Diabetic Retinopathy

1992
Analgesic use and chronic renal disease.
    The New England journal of medicine, 1989, May-11, Volume: 320, Issue:19

    Topics: Acetaminophen; Adult; Aged; Analgesics; Arthritis; Aspirin; Chronic Disease; Dose-Response Relations

1989
Worldwide safety experience with diclofenac.
    The American journal of medicine, 1986, Apr-28, Volume: 80, Issue:4B

    Topics: Adult; Aged; Aspirin; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Diclo

1986
[Effect of benzbromarone in uricemia and uricosuria].
    Die Medizinische Welt, 1972, Jan-22, Volume: 23, Issue:4

    Topics: Aspirin; Benzofurans; Chlorothiazide; Clinical Trials as Topic; Colchicine; Drug Combinations; Human

1972
Salicylates in the management of rheumatoid arthritis.
    Modern treatment, 1971, Volume: 8, Issue:4

    Topics: Aminobenzoates; Arthritis, Rheumatoid; Aspirin; Blood Coagulation; Buffers; Dyspepsia; Gastritis; Ga

1971

Other Studies

186 other studies available for aspirin and Kidney Diseases

ArticleYear
Antiplatelet agents for the secondary prevention of ischaemic stroke in patients with or without renal dysfunction.
    European journal of neurology, 2020, Volume: 27, Issue:3

    Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Glomerular Filtrat

2020
Searching for the Ideal Antiplatelet Therapy for CABG Patients With Kidney Disease.
    The Annals of thoracic surgery, 2022, Volume: 113, Issue:2

    Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Humans; Kidney Diseases; Platelet Aggregation Inhibito

2022
Short Communication: Evaluation of nephrotoxicity by aspirin-clopidogrel combination therapy in patients with acute coronary syndrome.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:6

    Topics: Acute Coronary Syndrome; Aspirin; Biomarkers; Blood Urea Nitrogen; Clopidogrel; Creatinine; Drug The

2016
Protective Effects of Nigella Sativaon Acetylsalicylic Acid-Induced Nephrotoxicity in Albino Rats.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017, Volume: 27, Issue:9

    Topics: Animals; Aspirin; Cytoprotection; Kidney Diseases; Nigella sativa; Phytotherapy; Plant Extracts; Pro

2017
Assessing Bleeding Risk in Patients Taking Anticoagulants.
    American family physician, 2017, Oct-01, Volume: 96, Issue:7

    Topics: Age Factors; Alcohol Drinking; Anemia; Anticoagulants; Aspirin; Atrial Fibrillation; Decision Suppor

2017
Short-term dual antiplatelet therapy after interventional left atrial appendage closure with different devices.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2018, 04-06, Volume: 13, Issue:18

    Topics: Age Factors; Aged; Aged, 80 and over; Aspirin; Atrial Appendage; Atrial Fibrillation; Cardiac Cathet

2018
Histological Effects of Nigella Sativa on Aspirin-Induced Nephrotoxicity in Albino Rats.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:10

    Topics: Animals; Aspirin; Cytoprotection; Humans; Kidney; Kidney Diseases; Male; Nigella sativa; Phytotherap

2018
Renal Dysfunction: The Wake-Up Alarm for Chronic Vascular Disease.
    Journal of the American College of Cardiology, 2019, 05-14, Volume: 73, Issue:18

    Topics: Aspirin; Factor Xa Inhibitors; Humans; Kidney Diseases; Rivaroxaban; Vascular Diseases

2019
Comparison of Three Tests to Distinguish Platelet Reactivity in Patients with Renal Impairment during Dual Antiplatelet Therapy.
    Nephron, 2016, Volume: 132, Issue:3

    Topics: Aged; Aspirin; Clopidogrel; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hemorrhage;

2016
Updates on baseline characteristics of the omega-3 fatty acids (Fish oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) study.
    Nephrology (Carlton, Vic.), 2017, Volume: 22, Issue:10

    Topics: Arteriovenous Shunt, Surgical; Aspirin; Fatty Acids, Omega-3; Fish Oils; Humans; Kidney Diseases

2017
Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan.
    Gastrointestinal endoscopy, 2016, Volume: 84, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Ce

2016
Protective Effects of Pinus halepensis L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats.
    Journal of oleo science, 2016, Aug-01, Volume: 65, Issue:8

    Topics: Acute Disease; Albinism; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Female; Kidney; K

2016
Decade-Long Trends (2001 to 2011) in the Use of Evidence-Based Medical Therapies at the Time of Hospital Discharge for Patients Surviving Acute Myocardial Infarction.
    The American journal of cardiology, 2016, Dec-15, Volume: 118, Issue:12

    Topics: Adrenergic beta-Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme I

2016
Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.
    Brazilian oral research, 2016, Nov-28, Volume: 30, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cycl

2016
Systematic underutilisation of secondary preventive drugs in patients with acute coronary syndrome and reduced renal function.
    European journal of preventive cardiology, 2017, Volume: 24, Issue:7

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspirin;

2017
Wunderlich syndrome during antiplatelet drug therapy.
    Clinical nephrology, 2009, Volume: 71, Issue:3

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Hematoma; Humans; Kidney Diseases; Leg; Lis

2009
Impact of anticoagulant therapy with dual antiplatelet therapy on prognosis after treatment with drug-eluting coronary stents.
    Journal of cardiology, 2010, Volume: 55, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardiovascular Diseases; Coronary Dis

2010
Aspirin and the prevention of cardiovascular disease in chronic kidney disease: time to move forward?
    Journal of the American College of Cardiology, 2010, Sep-14, Volume: 56, Issue:12

    Topics: Aspirin; Cardiovascular Diseases; Chronic Disease; Creatinine; Glomerular Filtration Rate; Hemorrhag

2010
Page kidney Doppler ultrasound.
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:1

    Topics: Aspirin; Diagnosis, Differential; Diastole; Hematoma; Humans; Hypertension, Renal; Kidney Diseases;

2011
Low responsiveness to clopidogrel increases risk among CKD patients undergoing coronary intervention.
    Journal of the American Society of Nephrology : JASN, 2011, Volume: 22, Issue:4

    Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chronic Disease; Clopidogrel; Cohort Studies; Coronar

2011
Aspirin and arteriovenous graft thrombosis in hemodialysis: just what the doctor ordered?
    Journal of the American Society of Nephrology : JASN, 2011, Volume: 22, Issue:4

    Topics: Arteriovenous Shunt, Surgical; Aspirin; Chronic Disease; Dipyridamole; Humans; Kidney Diseases; Plat

2011
Effects of preoperative aspirin on cardiocerebral and renal complications in non-emergent cardiac surgery patients: a sub-group and cohort study.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Aged; Aspirin; Cardiac Surgical Procedures; Cardiovascular Diseases; Case-Control Studies; Cohort St

2012
The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.
    Seminars in perinatology, 2002, Volume: 26, Issue:6

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox

2002
Ocular tilt reaction due to a mesencephalic lesion in juvenile polyarteritis nodosa.
    American journal of ophthalmology, 2003, Volume: 135, Issue:2

    Topics: Aspirin; Brain Diseases; Child, Preschool; Cyclophosphamide; Diplopia; Drug Therapy, Combination; Fe

2003
[Modification of staphylococcal infections of the rat kidney by analgesics].
    Arzneimittel-Forschung, 1961, Volume: 11

    Topics: Analgesics; Animals; Aspirin; Kidney Diseases; Phenacetin; Rats; Staphylococcal Infections

1961
Renal irritation caused by salicylates.
    Lancet (London, England), 1963, Feb-16, Volume: 1, Issue:7277

    Topics: Aspirin; Humans; Kidney; Kidney Diseases; Kidney Tubules; Salicylates; Skin Diseases

1963
Nephrotoxic effect of phenacetin and acetylsalicylic acid in animal experiments.
    Acta medica Scandinavica, 1962, Volume: 172

    Topics: Animal Experimentation; Animals; Aspirin; Humans; Kidney Diseases; Phenacetin

1962
GOUT. A FIVE-YEAR REVIEW.
    Pennsylvania medical journal (1928), 1963, Volume: 66

    Topics: Adrenocorticotropic Hormone; Arthritis; Aspirin; Codeine; Colchicine; Diagnosis, Differential; Diet;

1963
RENAL CHANGES ASSOCIATED WITH ANALGESIC DRUGS.
    Lancet (London, England), 1964, Apr-11, Volume: 1, Issue:7337

    Topics: Analgesics; Aspirin; Kidney; Kidney Diseases; Phenacetin; Toxicology

1964
ANALGESIC NEPHROTOXICITY; A PHARMACOLOGICAL ANALYSIS.
    The American journal of medicine, 1964, Volume: 36

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antipyrine; Aspirin; Kidney Diseases; Methemoglo

1964
HISTOLOGICAL CHANGES IN RABBIT KIDNEYS INDUCED BY PHENACETIN AND ACETYLSALICYLIC ACID.
    Lancet (London, England), 1964, Aug-22, Volume: 2, Issue:7356

    Topics: Aspirin; Kidney; Kidney Diseases; Pathology; Pharmacology; Phenacetin; Rabbits; Research; Toxicology

1964
THE EFFECT OF ASPIRIN AND PHENACETIN ON ASCENDING INFECTION IN THE RAT KIDNEY.
    Australasian annals of medicine, 1964, Volume: 13

    Topics: Aspirin; Escherichia coli Infections; Kidney Diseases; Pathology; Pharmacology; Phenacetin; Pyelonep

1964
PHENACETIN NEPHROPATHY.
    Canadian Medical Association journal, 1965, Jan-09, Volume: 92

    Topics: Acidosis; Animals; Aspirin; Bacteriuria; Biological Transport; Caffeine; Codeine; Dogs; Drug Therapy

1965
[THERAPEUTIC COMPLICATIONS OF ANALGESIC MEDICATIONS].
    Concours medical, 1964, Nov-14, Volume: 86

    Topics: Agranulocytosis; Aminopyrine; Analgesics; Anemia; Anemia, Hemolytic; Aspirin; Drug Hypersensitivity;

1964
NEPHROPATHY ASSOCIATED WITH THE USE OF ANALGESIC MEDICATIONS.
    Annals of internal medicine, 1965, Volume: 62

    Topics: Acute Kidney Injury; Amobarbital; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antip

1965
ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA.
    Lancet (London, England), 1965, May-15, Volume: 1, Issue:7394

    Topics: Aspirin; Brain Diseases; Carbohydrate Metabolism; Coma; Fatty Liver; Heart Diseases; Humans; Kidney

1965
Preventing diabetic retinopathy through control of systemic factors.
    Current opinion in ophthalmology, 2003, Volume: 14, Issue:6

    Topics: Anticoagulants; Aspirin; Diabetic Angiopathies; Diabetic Retinopathy; Disease Progression; Female; G

2003
Statins and aspirin in chronic kidney disease: what does the UK-HARP-I trial tell us?
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3

    Topics: Aspirin; Cardiovascular Diseases; Cholesterol; Chronic Disease; Disease Progression; Hemorrhage; Hum

2005
Antiplatelet therapy and spontaneous perirenal hematoma.
    International journal of urology : official journal of the Japanese Urological Association, 2005, Volume: 12, Issue:4

    Topics: Abdominal Pain; Aged; Aspirin; Diagnosis, Differential; Follow-Up Studies; Hematoma; Humans; Ischemi

2005
Association between body mass index and CKD in apparently healthy men.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:5

    Topics: Adult; Aspirin; beta Carotene; Body Mass Index; Cardiovascular Diseases; Chronic Disease; Cohort Stu

2005
The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.
    Diabetes, 2006, Volume: 55, Issue:1

    Topics: Animals; Apolipoproteins E; Arachidonate 12-Lipoxygenase; Aspirin; Diabetes Mellitus, Experimental;

2006
Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure.
    Circulation, 2006, Jun-06, Volume: 113, Issue:22

    Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Ste

2006
Spontaneous abdominal hematoma in a patient treated with clopidogrel and aspirin.
    Annals of hematology, 2006, Volume: 85, Issue:10

    Topics: Abdominal Cavity; Abdominal Pain; Aged; Aspirin; Clopidogrel; Hematoma; Humans; Kidney Diseases; Mal

2006
[NSAIDs and cardiovascular and renal complications].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenas

2006
Effects of applying a standardised management algorithm for moderate to severe renal dysfunction in patients with chronic stable heart failure.
    European journal of heart failure, 2007, Volume: 9, Issue:4

    Topics: Aged; Algorithms; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Creatinine; Female

2007
Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled catheters.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2007, Volume: 49, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aspirin; Bacteremia; Catheters, Indwelling; F

2007
Analgesic nephropathy.
    Kidney international, 2007, Volume: 72, Issue:4

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Drug Combinations; Headache; Humans; Kidney

2007
2007 Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2008, Jan-01, Volume: 71, Issue:1

    Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin;

2008
Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008, Volume: 51, Issue:4

    Topics: Acetaminophen; Adult; Aged; Albuminuria; Analgesics; Aspirin; Cross-Sectional Studies; Female; Glome

2008
Renal colic due to spontaneous perirenal haematoma secondary to antiplatelet medication: two case reports.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2008, Volume: 15, Issue:2

    Topics: Aspirin; Colic; Hematoma; Humans; Kidney Diseases; Male; Middle Aged; Platelet Aggregation Inhibitor

2008
Beta 2-microglobulin and other proteins as parameter for tubular function.
    Contributions to nephrology, 1981, Volume: 24

    Topics: Acetaminophen; Amino Acid Sequence; Aspirin; beta 2-Microglobulin; Beta-Globulins; Female; Graft Rej

1981
Clinical assessment of the renal toxicity of antirheumatic drugs.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1984, Volume: 7

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dinoprostone

1984
Sympathetic nervous activity, renin-angiotensin system and renal excretion of prostaglandin E2 in cirrhosis. Relationship to functional renal failure and sodium and water excretion.
    European journal of clinical investigation, 1983, Volume: 13, Issue:3

    Topics: Ascites; Aspirin; Dinoprostone; Diuresis; Glomerular Filtration Rate; Humans; Kidney Diseases; Liver

1983
[Analgesic nephropathy. II. Analgesic nephropathy and analgesic syndrome, diagnosis and treatment].
    Casopis lekaru ceskych, 1984, Aug-31, Volume: 123, Issue:35

    Topics: Adult; Aspirin; Female; Humans; Kidney Diseases; Male; Middle Aged; Phenacetin; Substance-Related Di

1984
Primary drug therapy: aspirin vs. the nonsteroidal anti-inflammatory drugs.
    Postgraduate medicine, 1983, Volume: Spec No

    Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Central Nervous System Diseases; Chemical and Drug Ind

1983
[Combination therapy with prednisone, chlorambucil, dipyridamole and aspirin in various glomerular diseases. Experience with 33 patients].
    Revista medica de Chile, 1983, Volume: 111, Issue:4

    Topics: Aspirin; Chlorambucil; Dipyridamole; Drug Therapy, Combination; Humans; Kidney Diseases; Prednisone

1983
Platelet adhesion to collagen in normal and von Willebrand's disease subjects.
    Thrombosis research, 1980, Mar-01, Volume: 17, Issue:5

    Topics: Animals; Aspirin; Blood Platelets; Collagen; Diabetes Mellitus; Dipyridamole; Factor VIII; Humans; K

1980
Nephrotoxicity of mild analgesics in the Gunn strain of rat.
    British journal of clinical pharmacology, 1980, Volume: 10 Suppl 2

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Glucuronosyltransferase; Kidney Diseases; Kidney Medull

1980
A new reproducible experimental model of analgesic nephropathy.
    The Journal of pathology, 1983, Volume: 139, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Antipyrine; Aspirin; Disease Models, Animal; Female; Kidney; Kid

1983
Noninvasive radioisotopic technique for detection of platelet deposition in mitral valve prostheses and quantitation of visceral microembolism in dogs.
    Mayo Clinic proceedings, 1983, Volume: 58, Issue:5

    Topics: Animals; Aspirin; Blood Platelets; Brain Diseases; Dipyridamole; Dogs; Embolism; Heart Valve Prosthe

1983
[Acetylsalicylic acid and renal function].
    Ugeskrift for laeger, 1983, Jan-31, Volume: 145, Issue:5

    Topics: Adult; Aged; Aspirin; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Mid

1983
Analgesic abuse and the kidney.
    Kidney international, 1980, Volume: 17, Issue:2

    Topics: Aged; Analgesics; Aspirin; Caffeine; Codeine; Drug Combinations; Humans; Kidney; Kidney Diseases; Ki

1980
Aspirin and analgesic nephropathy.
    JAMA, 1982, Jan-01, Volume: 247, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Creatinine; Female; History, 17th Century; Humans; Kidn

1982
The safety of treating rheumatoid arthritis with aspirin.
    JAMA, 1982, Jan-01, Volume: 247, Issue:1

    Topics: Arthritis, Rheumatoid; Aspirin; Humans; Kidney; Kidney Diseases; Risk; Time Factors

1982
Epidemiology of analgesic nephropathy in Belgium.
    Clinical nephrology, 1982, Volume: 17, Issue:3

    Topics: Acetaminophen; Analgesics; Antipyrine; Aspirin; Belgium; Caffeine; Drug Combinations; Humans; Kidney

1982
An update on long-term efficacy and safety with benoxaprofen.
    European journal of rheumatology and inflammation, 1982, Volume: 5, Issue:2

    Topics: Alkaline Phosphatase; Anemia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Ibup

1982
The influence of metabolic variation on analgesic nephrotoxicity. Experiments with the Gunn rat.
    Pathology, 1982, Volume: 14, Issue:4

    Topics: Acetaminophen; Aminophenols; Aminosalicylic Acids; Analgesics; Animals; Aspirin; Genetic Carrier Scr

1982
Analgesic nephropathy.
    British journal of hospital medicine, 1981, Volume: 25, Issue:3

    Topics: Adult; Analgesics; Aspirin; Female; Humans; Kidney Diseases; Kidney Neoplasms; Male; Middle Aged; Ph

1981
Acetaminophen as an aspirin substitute: is it safer?
    Chemical dependencies, 1980, Volume: 4, Issue:1-2

    Topics: Acetaminophen; Aspirin; Biotransformation; Cardiomyopathies; Chemical and Drug Induced Liver Injury;

1980
[Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity (author's transl)].
    Toxicological European research. Recherche europeenne en toxicologie, 1981, Volume: 3, Issue:3

    Topics: Acetylglucosaminidase; Animals; Aspirin; Gentamicins; Hexosaminidases; Kidney Diseases; Male; Mice

1981
Nephropathy as a hazard of analgesic abuse.
    American journal of hospital pharmacy, 1981, Volume: 38, Issue:10

    Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Aspirin; Female; Humans; Kidney Diseases; Male; M

1981
Acetylsalicylic acid and renal function.
    British medical journal, 1980, Mar-01, Volume: 280, Issue:6214

    Topics: Aged; Aspirin; Bone Diseases; Creatinine; Female; Giant Cell Arteritis; Glomerular Filtration Rate;

1980
Amelioration of radiation nephropathy by acetylsalicylic acid.
    International journal of radiation biology, 1995, Volume: 67, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Female; Kidney Diseases; Kidney Function Tests; Mice

1995
Captopril and aspirin in treatment of renal microangiopathy in primary antiphospholipid syndrome.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1995, Volume: 25, Issue:3

    Topics: Adult; Antiphospholipid Syndrome; Arterioles; Aspirin; Captopril; Drug Therapy, Combination; Female;

1995
Alleviation of experimental cyclosporin A nephrotoxicity by low dose aspirin in the rat.
    Biochemical pharmacology, 1993, Dec-03, Volume: 46, Issue:11

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Creatinine; Cyclosporine; Kidney Diseases; Male; Rat

1993
Renal prostaglandins and thromboxane A2 lack a functional significance in the genesis of protein-induced glomerular hyperfiltration in human renal disease.
    Nephron, 1993, Volume: 63, Issue:1

    Topics: Adult; Arachidonic Acids; Aspirin; Dietary Proteins; Dinoprost; Dinoprostone; Female; Glomerular Fil

1993
Analgesics and the kidney: summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an Ad Hoc Committee of the National Kidney Foundation.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 27, Issue:1

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Kidney Diseases

1996
Over-the-counter analgesics and kidney disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 27, Issue:6

    Topics: Acetaminophen; Analgesics; Aspirin; Drug Combinations; Headache; Humans; Kidney Diseases; Nonprescri

1996
Analgesic nephropathy. Proceedings of a symposium. June 1995.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:1 Suppl 1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1996
Prevention of preeclampsia with heparin and antiplatelet drugs in women with renal disease.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1995, Volume: 35, Issue:4

    Topics: Adult; Anticoagulants; Aspirin; Dipyridamole; Female; Heparin; Humans; Kidney Diseases; Platelet Agg

1995
Studies on the chronic oral toxicity of an analgesic drug combination consisting of acetylsalicylic acid, paracetamol and caffeine in rats including an electron microscopical evaluation of kidneys.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:9

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Blood Cell Count; Body Weight; Caffeine; Central Nervou

1996
Clinical consequences of nonnarcotic analgesic use.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1997
Commentary on the National Kidney Foundation position paper on analgesics and the kidney.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:5

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; C

1996
Analgesics and the kidney: recommendations of the National Kidney Foundation for the use of analgesics.
    Le Journal medical libanais. The Lebanese medical journal, 1996, Volume: 44, Issue:3

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal;

1996
[Predictive factors for development of hemolytic uremic syndrome (HUS) and early intensive treatments for prevention of HUS enterohemorrhagic Escherichia coli infection].
    The Japanese journal of antibiotics, 1997, Volume: 50, Issue:11

    Topics: Abdominal Pain; Adolescent; Age Factors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroi

1997
Analgesic nephropathy.
    The New England journal of medicine, 1998, Jul-02, Volume: 339, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Caffeine; Drug Combinations; Drug Interactions; Hu

1998
Analgesic nephropathy: clinical features and pathogenesis. Original data on the incidence and prevalence in a single renal unit.
    Acta clinica Belgica, 1998, Volume: 53, Issue:5

    Topics: Adult; Age Factors; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin

1998
Influence of acetylsalicylic acid on development of radiation-induced nephropathy.
    International journal of radiation biology, 2000, Volume: 76, Issue:11

    Topics: Animals; Aspirin; Dose-Response Relationship, Radiation; Edetic Acid; Female; Humans; In Vitro Techn

2000
Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation.
    The British journal of surgery, 2001, Volume: 88, Issue:2

    Topics: Aspirin; Biopsy, Needle; Chronic Disease; Cyclooxygenase Inhibitors; Follow-Up Studies; Graft Reject

2001
Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment.
    Annals of the rheumatic diseases, 2001, Volume: 60, Issue:5

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antiphospholipid Syndrome; Asp

2001
Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:10

    Topics: Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Aspirin; CD4-Positive T-Lym

2001
Acetaminophen, aspirin, and renal failure.
    The New England journal of medicine, 2002, May-16, Volume: 346, Issue:20

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; K

2002
Analgesic nephropathy.
    Australian family physician, 1976, Volume: 5, Issue:3

    Topics: Acidosis; Analgesics, Opioid; Aspirin; Australia; Dehydration; Health Education; Humans; Kidney Dise

1976
Acquired causes of hyperuricaemia.
    Australian and New Zealand journal of medicine, 1978, Volume: 8 Suppl 1

    Topics: Alcohol Drinking; Aspirin; Diet; Energy Intake; Gout; Humans; Kidney Diseases; Phenylbutazone; Uric

1978
Salicylate-induced enzymuria: comparison with other anti-inflammatory agents.
    The American journal of medicine, 1978, Volume: 65, Issue:6

    Topics: Acetaminophen; Acetylglucosaminidase; Adult; Anti-Inflammatory Agents; Aspirin; Gold; Hexosaminidase

1978
Drug-related nephropathy.
    Contributions to nephrology, 1978, Volume: 10

    Topics: Analgesics; Aspirin; Heroin Dependence; Humans; Inulin; Kidney; Kidney Cortex Necrosis; Kidney Disea

1978
Nephrotoxicity studies on aspirin and diflunisal.
    Current medical research and opinion, 1978, Volume: 5, Issue:7

    Topics: Acetylglucosamine; Analgesics; Aspirin; Biphenyl Compounds; Epithelial Cells; Female; Humans; Kidney

1978
Analgesic nephropathy in Canada: clinical syndrome, management, and outcome.
    Kidney international, 1978, Volume: 13, Issue:1

    Topics: Adult; Aged; Analgesics; Aspirin; Caffeine; Canada; Codeine; Creatinine; Drug Combinations; Female;

1978
Analgesic-associated nephropathy in the U.S.A.: epidemiologic, clinical and pathogenetic features.
    Kidney international, 1978, Volume: 13, Issue:1

    Topics: Acetaminophen; Adult; Aged; Analgesics; Animals; Aspirin; Creatinine; Drug Combinations; Female; Fol

1978
[Nephropathy caused by cystinosis with secondary Bartter's syndrome. Personal experience in a case treated with prolonged diet therapy and acetylsalicylic acid therapy].
    Minerva pediatrica, 1978, Nov-30, Volume: 30, Issue:22

    Topics: Aspirin; Bartter Syndrome; Child, Preschool; Cystinosis; Female; Humans; Hyperaldosteronism; Infant;

1978
Role of aspirin in renal disease.
    Postgraduate medicine, 1977, Volume: 61, Issue:3

    Topics: Aspirin; Humans; Kidney; Kidney Diseases; Pain; Phenacetin

1977
Analgesic nephropathy, 1972-76.
    Canadian Medical Association journal, 1977, Jul-09, Volume: 117, Issue:1

    Topics: Aspirin; Caffeine; Codeine; Drug Therapy, Combination; Humans; Kidney Diseases; Phenacetin

1977
Phensic addiction.
    The Ulster medical journal, 1977, Volume: 46, Issue:2

    Topics: Adult; Aspirin; Caffeine; Drug Combinations; Female; Humans; Kidney Diseases; Salicylamides; Substan

1977
Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy.
    The Journal of pathology, 1976, Volume: 120, Issue:1

    Topics: Animals; Aspirin; Connective Tissue; Connective Tissue Cells; Epithelial Cells; Epithelium; Female;

1976
Analgesics and the kidney: a community-based study.
    The Medical journal of Australia, 1976, Oct-02, Volume: 2, Issue:14

    Topics: Adult; Analgesics; Aspirin; Australia; Female; Humans; Kidney Diseases; Leukocytes; Male; Middle Age

1976
[Side and toxic effects of salicylates].
    La Clinica terapeutica, 1976, Oct-31, Volume: 79, Issue:2

    Topics: Aspirin; Chemical and Drug Induced Liver Injury; Female; Heart Diseases; Humans; Kidney Diseases; Ma

1976
Does aspirin play a role in analgesic nephropathy?
    Australian and New Zealand journal of medicine, 1976, Volume: 6 Suppl 1

    Topics: Animals; Aspirin; Caffeine; Dehydration; Drug Combinations; Female; Hot Temperature; Humidity; Kidne

1976
Analgesic abuse and kidney disease.
    Australian and New Zealand journal of medicine, 1976, Volume: 6, Issue:5

    Topics: Analgesics; Animals; Aspirin; Australia; Carcinoma, Transitional Cell; Female; Humans; Kidney Diseas

1976
Analgesic nephropathy.
    The Medical journal of Australia, 1976, May-15, Volume: 1, Issue:20

    Topics: Acetaminophen; Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Co

1976
Diseases causing end-stage renal failure in New South Wales.
    British medical journal, 1975, Feb-22, Volume: 1, Issue:5955

    Topics: Acetaminophen; Adult; Analgesics; Aspirin; Australia; Caffeine; Codeine; Cystoscopy; Female; Glomeru

1975
Letter: Possible role of laxatives in analgesic nephropathy.
    British medical journal, 1975, Apr-19, Volume: 2, Issue:5963

    Topics: Analgesics; Aspirin; Cathartics; Codeine; Female; Humans; Kidney Diseases; Male; Phenacetin; Substan

1975
Preliminary report: treatment of the hemolytic-uremic syndrome with aspirin and dipyridamole.
    The Journal of pediatrics, 1975, Volume: 86, Issue:6

    Topics: Acute Disease; Anemia, Hemolytic; Aspirin; Blood Platelet Disorders; Blood Platelets; Blood Transfus

1975
Editorial: Analgesic nephropathy: some unsolved problems.
    The Medical journal of Australia, 1975, Feb-15, Volume: 1, Issue:7

    Topics: Analgesics; Animals; Aspirin; Humans; Kidney Diseases; Kidney Papillary Necrosis; Phenacetin; Rats;

1975
The failure of high doses of aspirin to produce renal lesions in pigs.
    The Medical journal of Australia, 1975, Feb-15, Volume: 1, Issue:7

    Topics: Animals; Aspirin; Female; Kidney; Kidney Diseases; Male; Swine

1975
Analgesic abuse in urological practice.
    The British journal of surgery, 1975, Volume: 62, Issue:4

    Topics: Acute Kidney Injury; Adult; Aged; Anemia; Aspirin; Codeine; Female; Humans; Hypertension; Kidney Cal

1975
[Analgesic nephropathy].
    Medizinische Klinik, 1975, May-16, Volume: 70, Issue:20

    Topics: Acidosis, Renal Tubular; Analgesics; Aspirin; Autopsy; Caffeine; Creatinine; Drug Interactions; Fema

1975
Letter: The clinical course of patients with analgesic nephropathy.
    Canadian Medical Association journal, 1975, Aug-09, Volume: 113, Issue:3

    Topics: Analgesics; Aspirin; Caffeine; Codeine; Creatinine; Female; Follow-Up Studies; Humans; Kidney; Kidne

1975
The radiological diagnosis of analgesic nephropathy.
    Clinical radiology, 1975, Volume: 26, Issue:3

    Topics: Adult; Aged; Aspirin; Atrophy; Calcinosis; Creatinine; Female; Humans; Hydronephrosis; Kidney; Kidne

1975
[Analgesic nephropathy. Interaction between analgetics and laxatives].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4

    Topics: Aspirin; Caffeine; Cathartics; Drug Interactions; Humans; Kidney Diseases

1976
[Kidney diseases associated with hemolytic uremic syndrome,thrombotic thrombocytopenic purpura and disseminated intravascular coagulation].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1992, Jan-10, Volume: 81, Issue:1

    Topics: Adolescent; Adult; Aspirin; Dipyridamole; Disseminated Intravascular Coagulation; Female; Hemolytic-

1992
Analgesic nephropathy in Fischer 344 rats: comparative effects of chronic treatment with either aspirin or paracetamol.
    Pathology, 1991, Volume: 23, Issue:2

    Topics: Acetaminophen; Animals; Aspirin; Female; Incidence; Kidney Concentrating Ability; Kidney Diseases; K

1991
An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987)
    The New England journal of medicine, 1991, Jan-17, Volume: 324, Issue:3

    Topics: Adult; Aged; Aspirin; Cardiovascular Diseases; Dose-Response Relationship, Drug; Female; Humans; Hyp

1991
Renal tubular hypouricemia: evidence for defect of both secretion and reabsorption.
    Nephron, 1990, Volume: 56, Issue:4

    Topics: Aged; Aspirin; Creatinine; Furosemide; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubule

1990
Large perirenal hematoma after extracorporeal shock-wave lithotripsy.
    Urology, 1990, Volume: 35, Issue:2

    Topics: Aged; Aspirin; Blood Coagulation; Hematoma; Humans; Kidney Calculi; Kidney Diseases; Lithotripsy; Ma

1990
Aspirin-induced bilateral renal hemorrhage after extracorporeal shock wave lithotripsy therapy: implications and conclusions.
    The Journal of urology, 1990, Volume: 143, Issue:4

    Topics: Aged; Aspirin; Hemorrhage; Humans; Kidney Calculi; Kidney Diseases; Lithotripsy; Male; Tomography, X

1990
Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol.
    Pathology, 1990, Volume: 22, Issue:1

    Topics: Acetaminophen; Animals; Aspirin; Body Weight; Disease Models, Animal; Female; Kidney Concentrating A

1990
Selective inhibition of platelet thromboxane generation with low-dose aspirin does not protect rats with reduced renal mass from the development of progressive disease.
    The American journal of pathology, 1989, Volume: 134, Issue:5

    Topics: Animals; Aspirin; Blood Platelets; Kidney; Kidney Diseases; Kidney Glomerulus; Male; Platelet Aggreg

1989
Lysine acetyl salicylic acid in acute renal pain.
    International urology and nephrology, 1989, Volume: 21, Issue:3

    Topics: Acute Disease; Adult; Analgesics; Aspirin; Colic; Dose-Response Relationship, Drug; Drug Evaluation;

1989
Analgesic use and chronic renal disease.
    The New England journal of medicine, 1989, Oct-19, Volume: 321, Issue:16

    Topics: Acetaminophen; Analgesics; Aspirin; Chronic Disease; Data Collection; Humans; Kidney Diseases; Phena

1989
Progression of renal failure in analgesic-associated nephropathy.
    Nephron, 1989, Volume: 53, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Creatinine; Female; Humans; Kidney; Kidney Diseases

1989
[Enzymuria and kidney diseases in childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1986, Volume: 134, Issue:12

    Topics: Acetylglucosaminidase; Adolescent; Aminopeptidases; Anti-Bacterial Agents; Aspirin; CD13 Antigens; C

1986
[Adverse effects of non-steroidal antirheumatic drugs with special reference to the gastrointestinal tract].
    Zeitschrift fur Rheumatologie, 1987, Volume: 46 Suppl 1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Drug Hypersensitivity; Gast

1987
Renal disease from habitual antipyretic analgesic consumption: an assessment of the epidemiologic evidence.
    Medicine, 1986, Volume: 65, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Kidney; Kidney Diseases; Kidney Failure, C

1986
[The significance of renal prostaglandins for kidney function in early childhood].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1987, Volume: 135, Issue:4

    Topics: Angiotensin II; Aspirin; Child, Preschool; Creatinine; Ductus Arteriosus, Patent; Glomerular Filtrat

1987
Salicylate nephropathy in the Gunn rat: potential role of prostaglandins.
    Prostaglandins, 1985, Volume: 30, Issue:3

    Topics: Animals; Aspirin; Dinoprostone; Heterozygote; Homozygote; In Vitro Techniques; Kidney Concentrating

1985
Anesthetic management of patients with coagulation disorders.
    International anesthesiology clinics, 1985,Summer, Volume: 23, Issue:2

    Topics: Anesthetics; Anticoagulants; Aspirin; Blood Coagulation; Blood Coagulation Disorders; Cardiopulmonar

1985
Aspirin and prednisone in microangiopathic haemolytic anaemia.
    Lancet (London, England), 1970, Jul-25, Volume: 2, Issue:7665

    Topics: Adult; Anemia, Hemolytic; Aspirin; Blood Platelet Disorders; Blood Urea Nitrogen; Erythrocytes, Abno

1970
Analgesic abuse in psychiatric patients.
    Lancet (London, England), 1970, Jun-20, Volume: 760, Issue:1

    Topics: Adult; Aged; Anemia; Aspirin; Creatinine; Dyspepsia; Female; Humans; Kidney Diseases; Male; Mental D

1970
[Kidney toxicity of analgesics].
    Deutsche medizinische Wochenschrift (1946), 1973, Aug-24, Volume: 98, Issue:34

    Topics: Acetaminophen; Administration, Oral; Aspirin; Humans; Kidney Diseases; Long-Term Care; Phenacetin

1973
[Drug eruptions and anaphylactic reactions at a Finnish central hospital].
    Duodecim; laaketieteellinen aikakauskirja, 1972, Volume: 88, Issue:19

    Topics: Adolescent; Adult; Age Factors; Aged; Ampicillin; Analgesics; Anaphylaxis; Angioedema; Anti-Bacteria

1972
Possible role of laxatives in analgesic nephropathy.
    British medical journal, 1974, Dec-21, Volume: 4, Issue:5946

    Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Cathartics; Codeine; Creatinine; Drug Combi

1974
Platelet disorders.
    Pediatric clinics of North America, 1972, Volume: 19, Issue:4

    Topics: Antibody Formation; Aspirin; Blood Cell Count; Blood Coagulation Disorders; Blood Coagulation Tests;

1972
Analgesic nephropathy and aspirin.
    The New Zealand medical journal, 1974, Jun-26, Volume: 79, Issue:518

    Topics: Analgesics; Aspirin; Female; Humans; Kidney Diseases; Male; Phenacetin; Substance-Related Disorders

1974
Analgesic nephropathy.
    The New Zealand medical journal, 1974, Jun-26, Volume: 79, Issue:518

    Topics: Adult; Aged; Analgesics; Anemia; Aspirin; Codeine; Drug Combinations; Female; Follow-Up Studies; Hum

1974
Personality factors in analgesic nephropathy.
    Psychological medicine, 1974, Volume: 4, Issue:1

    Topics: Adult; Aged; Analgesics; Aspirin; Creatinine; Extraversion, Psychological; Female; Gastrointestinal

1974
A kinetic evaluation of hemostasis in renal disease.
    The New England journal of medicine, 1974, Nov-21, Volume: 291, Issue:21

    Topics: Aspirin; Blood Coagulation; Complement System Proteins; Diabetic Nephropathies; Dipyridamole; Fibrin

1974
Urinary excretion of kidney antigens in rats consuming analgesics.
    Pathologia Europaea, 1972, Volume: 7, Issue:2

    Topics: Animals; Antigens; Aspirin; Diet; Female; Immune Sera; Immunodiffusion; Kidney Diseases; Kidney Tubu

1972
The use and abuse of analgesics.
    Scottish medical journal, 1972, Volume: 17, Issue:21

    Topics: Analgesics; Aspirin; Female; Humans; Kidney Diseases; Male; Mental Disorders; Scotland; Self Medicat

1972
Lysozymuria and acute disorders of renal function.
    Journal of clinical pathology, 1973, Volume: 26, Issue:4

    Topics: Acetaminophen; Acute Disease; Aspirin; Electroshock; Glomerulonephritis; Heart Failure; Humans; Hypo

1973
Toxic nephropathies.
    Texas medicine, 1973, Volume: 69, Issue:7

    Topics: Aspirin; Gentamicins; Humans; Kidney Diseases; Methoxyflurane; Phenacetin

1973
[Adverse effects of acetylosalicylic acid].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1973, Oct-09, Volume: 62, Issue:41

    Topics: Aspirin; Gastrointestinal Diseases; Humans; Hypoglycemia; Kidney Diseases

1973
[Risks in long-term treatment with analgesics].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Mar-30, Volume: 93, Issue:9

    Topics: Acetaminophen; Analgesics; Antipyrine; Aspirin; Caffeine; Diuresis; Drug Combinations; Humans; Kidne

1973
Drug-induced nephropathies.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:9

    Topics: Animals; Arthritis, Rheumatoid; Aspirin; Colic; Complement System Proteins; Glomerular Filtration Ra

1973
Aspirin and analgesic nephropathy.
    British medical journal, 1974, Mar-30, Volume: 1, Issue:5908

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Blood Pressure; Creatinine; Female; Humans; Kidney Dise

1974
Aspirin and the kidney. New Zealand Rheumatism Association Study.
    British medical journal, 1974, Mar-30, Volume: 1, Issue:5908

    Topics: Acetaminophen; Adult; Arthritis, Rheumatoid; Aspirin; Caffeine; Codeine; Drug Synergism; Female; Hum

1974
The binding of urate to plasma proteins.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Allopurinol; Aspirin; Binding Sites; Blood Proteins; Colchicine; Dialysis; Evaluation Studies as Top

1974
The clinical significance of hypouricemia.
    Advances in experimental medicine and biology, 1974, Volume: 41

    Topics: Allopurinol; Amino Acids; Aspirin; Autoanalysis; Creatinine; Glycosuria; Humans; Kidney Diseases; Ne

1974
Editorial: Choice of a mild analgesic.
    British medical journal, 1974, Jun-01, Volume: 2, Issue:5917

    Topics: Acetaminophen; Aspirin; Drug Combinations; Humans; Kidney Diseases; Phenacetin; Substance-Related Di

1974
Effect of chronic administration of analgesics on resistance to experimental infection of the urinary tract in rats.
    Nephron, 1968, Volume: 5, Issue:3

    Topics: Acetaminophen; Animals; Aspirin; Bacteriuria; Escherichia coli Infections; Female; Foreign Bodies; K

1968
[Enzyme determinations in nephrologic diagnosis].
    Schweizerische medizinische Wochenschrift, 1970, Sep-12, Volume: 100, Issue:37

    Topics: Adolescent; Adult; Aspirin; Clinical Enzyme Tests; Glucosidases; Graft Rejection; Humans; Isoenzymes

1970
Possible nephrotoxicity of aspirin in rheumatoid arthritis.
    The Medical journal of Australia, 1972, Mar-25, Volume: 1, Issue:13

    Topics: Age Factors; Arthritis, Rheumatoid; Aspirin; Glomerular Filtration Rate; Humans; Kidney Diseases

1972
Possible nephrotoxicity of aspirin in rheumatoid arthritis.
    The Medical journal of Australia, 1972, Mar-04, Volume: 1, Issue:10

    Topics: Arthritis, Rheumatoid; Aspirin; Caffeine; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Ph

1972
Analgesic nephropathy: removal of phenacetin from proprietary analgesics.
    British medical journal, 1972, Oct-21, Volume: 4, Issue:5833

    Topics: Analgesics; Aspirin; Caffeine; Codeine; Drug Combinations; Humans; Kidney Diseases; Phenacetin; Scot

1972
Clinical cases of renal calculi.
    Aerospace medicine, 1971, Volume: 42, Issue:9

    Topics: Adult; Aerospace Medicine; Aspirin; Depression; Female; Humans; Kidney Calculi; Kidney Diseases; Mal

1971
Acetaminophen, valadol, and analgesic renal injury.
    The Medical letter on drugs and therapeutics, 1971, Volume: 13, Issue:18

    Topics: Acetaminophen; Analgesics; Aspirin; Humans; Kidney Diseases; Kidney Papillary Necrosis; Nephritis, I

1971
Comparative nephrotoxicity of aspirin and phenacetin derivatives.
    British medical journal, 1971, Nov-27, Volume: 4, Issue:5786

    Topics: Aniline Compounds; Animals; Aspirin; Female; Kidney; Kidney Diseases; Kidney Papillary Necrosis; Kid

1971
[Kidney disease caused by analgesics].
    Revista clinica espanola, 1971, Aug-15, Volume: 122, Issue:3

    Topics: Adult; Analgesics; Aspirin; Codeine; Female; Humans; Kidney Diseases; Male; Phenacetin; Phenobarbita

1971
["Phenacetin-kidney" or "analgetic-nephropathy"].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Nov-20, Volume: 91, Issue:32

    Topics: Acetaminophen; Aspirin; Humans; Kidney Diseases; Phenacetin

1971
[Determination of uric acid in blood. Experimental determination; critical studies of the technics and results].
    Quaderni Sclavo di diagnostica clinica e di laboratorio, 1971, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aspirin; Autoanalysis; Female; Gout; Humans; Indicators and Reagents; Kidney Dise

1971
One-day renal function testing in normal rats and in cases of experimentally-induced analgesic nephropathy, nephrocalcinosis and nephrotic syndrome.
    Nephron, 1971, Volume: 8, Issue:3

    Topics: Animals; Aspirin; Caffeine; Citrates; Creatinine; Female; Hydrogen-Ion Concentration; Kidney; Kidney

1971
Headache nostrums and chronic illness.
    Journal of chronic diseases, 1966, Volume: 19, Issue:10

    Topics: Analgesics; Aspirin; Chronic Disease; Gastrointestinal Hemorrhage; Headache; Kidney Diseases; Monoam

1966
Analgesic habits of 500 veterans: incidence and complications of abuse.
    Canadian Medical Association journal, 1968, Mar-30, Volume: 98, Issue:13

    Topics: Adult; Aged; Analgesics; Anemia; Arthritis; Aspirin; Caffeine; Canada; Codeine; Gastrointestinal Hem

1968
Aspirin and alternatives.
    British medical journal, 1970, Jul-11, Volume: 3, Issue:5714

    Topics: Adult; Analgesics; Anti-Inflammatory Agents; Aspirin; Fever; Gastrointestinal Hemorrhage; Humans; In

1970
The binding of urate to plasma proteins determined by means of equilibrium dialysis.
    The Journal of laboratory and clinical medicine, 1970, Volume: 75, Issue:3

    Topics: Aspirin; Blood Proteins; Dialysis; Gout; Humans; Hydrogen-Ion Concentration; Hypoxanthines; Kidney D

1970
[Analgetics and kidney damage].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Jan-15, Volume: 90, Issue:2

    Topics: Analgesics; Animals; Aspirin; Humans; Kidney Diseases; Nicotine; Phenacetin; Rats

1970
Urinary cytology in experimental toxic renal injury.
    Annals of the rheumatic diseases, 1970, Volume: 29, Issue:5

    Topics: Acute Kidney Injury; Animals; Aspirin; Azirines; Chromates; Eosinophils; Histocytochemistry; Kidney

1970
Phenacetin nephropathy.
    British medical journal, 1970, Nov-21, Volume: 4, Issue:5733

    Topics: Acetaminophen; Animals; Aspirin; Caffeine; Humans; Kidney Diseases; Phenacetin; Rats

1970
Reye's syndrome and salicylate intoxication.
    Pediatrics, 1970, Volume: 46, Issue:6

    Topics: Adipose Tissue; Aspirin; Brain Diseases; Chemical and Drug Induced Liver Injury; Fatty Liver; Humans

1970
[Clinical and experimental studies on the phenacetin kidney].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1967, Volume: 73

    Topics: Aminohippuric Acids; Animals; Aspirin; Diuresis; Dogs; Guinea Pigs; Humans; Inulin; Kidney Diseases;

1967
Syndrome associated with the abuse of analgesics.
    Annals of internal medicine, 1968, Volume: 68, Issue:4

    Topics: Adult; Age Factors; Analgesics; Anemia; Animals; Aspirin; Caffeine; Cats; Dogs; Female; Guinea Pigs;

1968
Renal biopsies from patients with a high analgesic intake. Histological and bacteriological study.
    Acta pathologica et microbiologica Scandinavica, 1968, Volume: 72, Issue:2

    Topics: Adult; Aspirin; Biopsy; Female; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Kidney Tubul

1968
Statement on analgesic nephropathy.
    The Medical journal of Australia, 1969, Jun-28, Volume: 1, Issue:26

    Topics: Analgesics; Animals; Aspirin; Australia; Caffeine; Drug and Narcotic Control; Drug Labeling; Female;

1969
Renal accumulation of salicylate and phenacetin: possible mechanisms in the nephropathy of analgesic abuse.
    The Journal of clinical investigation, 1969, Volume: 47, Issue:11

    Topics: Analgesics; Animals; Aspirin; Dehydration; Dogs; Female; Humans; Hydrogen-Ion Concentration; Kidney;

1969
[Acute kidney damage after a suicide attempt with tablets containing phenacetin].
    Medizinische Klinik, 1965, Jul-02, Volume: 60, Issue:27

    Topics: Adult; Aspirin; Humans; Kidney Diseases; Male; Phenacetin; Suicide

1965
[Medicamentous (toxico-allergic) nephropathies].
    Revista clinica espanola, 1965, Oct-15, Volume: 99, Issue:1

    Topics: Aspirin; Humans; Kidney; Kidney Diseases; Middle Aged

1965
Phenacetin, aspirin, and kidney damage.
    American heart journal, 1966, Volume: 71, Issue:5

    Topics: Animals; Aspirin; Humans; Kidney Diseases; Phenacetin; Rabbits; Rats

1966