aspirin and Intracranial Aneurysm studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (

Research Excerpts

Excerpt	Relevance	Reference
"Studies reporting aspirin use and the occurrence of subarachnoid hemorrhage were included and grouped based on population (general population vs."	9.22	A meta-analysis of aspirin and subarachnoid hemorrhage in patients with intracranial aneurysms yields different results to the general population. ( Birks, J; Bulters, D; Ewbank, F, 2022)
"Aspirin has been suggested as a potential therapeutic strategy to prevent the growth and rupture of unruptured intracranial aneurysms (UIAs), but there is still controversy."	9.12	Aspirin and growth, rupture of unruptured intracranial aneurysms: A systematic review and meta-analysis. ( Guo, XM; Guo, Y; Yang, MF; Zhao, K, 2021)
"We initiated a multicenter, prospective cohort study to test the hypothesis that aspirin is safe for patients with ischemic cerebrovascular disease (ICVD) harboring unruptured intracranial aneurysms (UIAs) <7 mm."	8.02	Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms. ( Cao, Y; Du, X; Fu, WL; Huo, R; Jiao, YM; Li, H; Wang, J; Wang, S; Weng, JC; Xu, HY; Yan, ZH; Zhao, JZ, 2021)
" The aim of this study was to assess the safety and efficacy of the p48 MW HPC (phenox, Bochum, Germany) to treat distal intracranial aneurysms under the use of aspirin monotherapy."	8.02	Aspirin monotherapy in the treatment of distal intracranial aneurysms with a surface modified flow diverter: a pilot study. ( Abud, DG; Abud, TG; de Castro-Afonso, LH; de Freitas, RK; Monsignore, LM; Nakiri, GS, 2021)
"The role of aspirin in unruptured intracranial aneurysm (UIA) growth remains largely unknown."	7.96	Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study. ( Cao, Y; Du, X; Fu, WL; Huo, R; Jiao, YM; Li, H; Wang, J; Wang, S; Weng, JC; Xu, HY; Yan, ZH; Zhan, J; Zhao, JZ, 2020)
"From October 2017 to November 2018, 7 consecutive patients (5 females, 2 males, mean age = 56 years) were managed with cangrelor as antiplatelet therapy, combined with aspirin, for stent-assisted coiling embolization and flow-diverter embolization of challenging intracranial aneurysms."	7.96	Preliminary Experience with Cangrelor for Endovascular Treatment of Challenging Intracranial Aneurysms. ( Abdennour, L; Bernard, R; Carpentier, A; Clarençon, F; Degos, V; Drir, M; Godier, A; Lenck, S; Mathout, J; Premat, K; Shotar, E; Sourour, N; Taylor, G, 2020)
"OBJECTIVE Although aspirin usage may be associated with a decreased risk of rupture of cerebral aneurysms, any potential therapeutic benefit from aspirin must be weighed against the theoretical risk of greater hemorrhage volume if subarachnoid hemorrhage (SAH) occurs."	7.85	The impact of aspirin and anticoagulant usage on outcomes after aneurysmal subarachnoid hemorrhage: a Nationwide Inpatient Sample analysis. ( Ali Aziz-Sultan, M; Dasenbrock, HH; Du, R; Frerichs, KU; Gormley, WB; Gross, BA; Guttieres, D; Yan, SC, 2017)
" Diabetes mellitus and current smoker status were independent factors related to reactivity to clopidogrel."	7.83	Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. ( Hironaka, Y; Kichikawa, K; Motoyama, Y; Nakagawa, I; Nakase, H; Park, HS; Takayama, K; Wada, T; Yokoyama, S, 2016)
" In this study, the authors assess the incidence of stroke or transient ischemic attack (TIA) following discontinuation of a 6-week course of clopidogrel in patients with cerebral aneurysms treated with stent-assisted techniques."	7.78	Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques. ( Abel, TJ; Chalouhi, N; Hasan, DM; Jabbour, PM; Kung, DK; Rossen, JD; Thomas, J; Wassef, SN, 2012)
"This follow-up study was designed to evaluate whether the use of aspirin either before or after aneurysm rupture affects the occurrence of delayed cerebral ischemia."	7.69	Aspirin and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. ( Juvela, S, 1995)
"Flow diversion for ruptured aneurysms under SAPT with coated stents is feasible."	7.01	A Systematic Literature Review and Meta-Analysis of the Treatment of Ruptured Intracranial Aneurysms with Hydrophilic Polymer and Phosphorylcholine-Coated Flow Diverters Under Single Antiplatelet Therapy. ( Gawlitza, M; Kaiser, DPO; Klisch, J; Linn, J; Lobsien, D; Pierot, L, 2023)
" Dosing for neuroendovascular conditions is often extrapolated from the cardiac literature, although outcomes in cardiac patients may not be relevant to neurologic patients, making prophylactic treatment recommendations challenging for these patients."	6.61	Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel-Hyporesponsive Patients. ( Barra, ME; Berger, K; Brophy, GM; Tesoro, EP, 2019)
"Aspirin is a potent inhibitor of cyclooxygenase-2 (COX), which plays a critical role in the expression of immune modulators known to contribute to cerebral aneurysm formation and rupture."	6.52	Potential role of aspirin in the prevention of aneurysmal subarachnoid hemorrhage. ( Chalouhi, N; Ding, D; Hasan, DM; Starke, RM, 2015)
"Intracranial aneurysms were induced in wild-type and mPGES-1 knockout (mPGES-1 KO) mice by using a combination of deoxycorticosterone acetate-salt-induced hypertension and intracranial injection of elastase in the basal cistern."	5.42	Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. ( Faraci, FM; Granja, MF; Harty, JT; Hasan, DM; Heistad, DD; Kung, DK; Mitchell, IJ; Peña Silva, RA; Pewe, LL, 2015)
"Studies reporting aspirin use and the occurrence of subarachnoid hemorrhage were included and grouped based on population (general population vs."	5.22	A meta-analysis of aspirin and subarachnoid hemorrhage in patients with intracranial aneurysms yields different results to the general population. ( Birks, J; Bulters, D; Ewbank, F, 2022)
"Aspirin has been suggested as a potential therapeutic strategy to prevent the growth and rupture of unruptured intracranial aneurysms (UIAs), but there is still controversy."	5.12	Aspirin and growth, rupture of unruptured intracranial aneurysms: A systematic review and meta-analysis. ( Guo, XM; Guo, Y; Yang, MF; Zhao, K, 2021)
"We initiated a multicenter, prospective cohort study to test the hypothesis that aspirin is safe for patients with ischemic cerebrovascular disease (ICVD) harboring unruptured intracranial aneurysms (UIAs) <7 mm."	4.02	Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms. ( Cao, Y; Du, X; Fu, WL; Huo, R; Jiao, YM; Li, H; Wang, J; Wang, S; Weng, JC; Xu, HY; Yan, ZH; Zhao, JZ, 2021)
" The aim of this study was to assess the safety and efficacy of the p48 MW HPC (phenox, Bochum, Germany) to treat distal intracranial aneurysms under the use of aspirin monotherapy."	4.02	Aspirin monotherapy in the treatment of distal intracranial aneurysms with a surface modified flow diverter: a pilot study. ( Abud, DG; Abud, TG; de Castro-Afonso, LH; de Freitas, RK; Monsignore, LM; Nakiri, GS, 2021)
"The role of aspirin in unruptured intracranial aneurysm (UIA) growth remains largely unknown."	3.96	Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study. ( Cao, Y; Du, X; Fu, WL; Huo, R; Jiao, YM; Li, H; Wang, J; Wang, S; Weng, JC; Xu, HY; Yan, ZH; Zhan, J; Zhao, JZ, 2020)
"From October 2017 to November 2018, 7 consecutive patients (5 females, 2 males, mean age = 56 years) were managed with cangrelor as antiplatelet therapy, combined with aspirin, for stent-assisted coiling embolization and flow-diverter embolization of challenging intracranial aneurysms."	3.96	Preliminary Experience with Cangrelor for Endovascular Treatment of Challenging Intracranial Aneurysms. ( Abdennour, L; Bernard, R; Carpentier, A; Clarençon, F; Degos, V; Drir, M; Godier, A; Lenck, S; Mathout, J; Premat, K; Shotar, E; Sourour, N; Taylor, G, 2020)
"Aspirin prevented aneurysm rupture in a mouse intracranial aneurysm model, while cilostazol did not."	3.88	Prevention Effect of Antiplatelets on Aneurysm Rupture in a Mouse Intracranial Aneurysm Model. ( Hiramatsu, H; Hokamura, K; Kamio, Y; Kimura, T; Makino, H; Namba, H; Suzuki, T; Umemura, K; Yamasaki, T, 2018)
"Aspirin is a promising medical therapy for the prevention of intracranial aneurysm (IA) rupture."	3.85	Sex Differential in 15-Hydroxyprostaglandin Dehydrogenase Levels in the Lumen of Human Intracranial Aneurysms. ( Chalouhi, N; Hasan, DM; Jabbour, P; Nakagawa, D; Starke, RM; Torner, J; Zanaty, M, 2017)
" They then performed a controlled before-and-after study in 79 patients with ruptured aneurysms who were deemed to be at high risk for TEEs (for example, patients with at least 1 angiographic feature associated with TEEs) to evaluate whether selective aspirin administration would reduce the rate of periprocedural thromboembolism without increasing major hemorrhagic complications."	3.85	Antiplatelet therapy for the prevention of peri-coiling thromboembolism in high-risk patients with ruptured intracranial aneurysms. ( Chen, PR; Corona, J; Dannenbaum, M; Edwards, NJ; Jones, WH; Sanzgiri, A, 2017)
"OBJECTIVE Although aspirin usage may be associated with a decreased risk of rupture of cerebral aneurysms, any potential therapeutic benefit from aspirin must be weighed against the theoretical risk of greater hemorrhage volume if subarachnoid hemorrhage (SAH) occurs."	3.85	The impact of aspirin and anticoagulant usage on outcomes after aneurysmal subarachnoid hemorrhage: a Nationwide Inpatient Sample analysis. ( Ali Aziz-Sultan, M; Dasenbrock, HH; Du, R; Frerichs, KU; Gormley, WB; Gross, BA; Guttieres, D; Yan, SC, 2017)
" Diabetes mellitus and current smoker status were independent factors related to reactivity to clopidogrel."	3.83	Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. ( Hironaka, Y; Kichikawa, K; Motoyama, Y; Nakagawa, I; Nakase, H; Park, HS; Takayama, K; Wada, T; Yokoyama, S, 2016)
" In this study, the authors assess the incidence of stroke or transient ischemic attack (TIA) following discontinuation of a 6-week course of clopidogrel in patients with cerebral aneurysms treated with stent-assisted techniques."	3.78	Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques. ( Abel, TJ; Chalouhi, N; Hasan, DM; Jabbour, PM; Kung, DK; Rossen, JD; Thomas, J; Wassef, SN, 2012)
"To report any potential complication associated with the use of both aspirin and clopidogrel in stent assisted coiling of ruptured wide necked intracranial aneurysms."	3.78	Stent assisted coiling of the ruptured wide necked intracranial aneurysm. ( Deshaies, E; El-Zammar, Z; Fessler, RD; Latorre, JG; Lodi, YM; Swarnkar, A, 2012)
"Frequent aspirin use may confer a protective effect for risk of intracranial aneurysm rupture."	3.77	Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture. ( Brown, RD; Capuano, AW; Hasan, DM; Huston, J; Mahaney, KB; Meissner, I; Piepgras, DG; Torner, JC, 2011)
"Data obtained in this study suggest a suboptimal clopidogrel response in patients with greater body weight and body mass index."	3.77	Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting. ( Alexander, MJ; Choulakian, A; Drazin, D; Kornbluth, P; Nuño, M, 2011)
" We report our initial experience using a new self-expanding easy-to-place nitinol stent (Enterprise) in the treatment of wide-neck intracranial aneurysms."	3.74	A new self-expandable nitinol stent for the treatment of wide-neck aneurysms: initial clinical experience. ( Beute, GN; Peluso, JP; Sluzewski, M; van Rooij, WJ, 2008)
"Between August 2001 and January 2004 we treated nine acute subarachnoid hemorrhage (SAH) patients with a combination of stents and platinum coils."	3.73	[Stenting plus coiling: dangerous or helpful?]. ( Dörfler, A; Forsting, M; Gizewski, E; Stolke, D; Wanke, I, 2005)
"Recently developed interventional radiologic techniques, such as embolization with platinum coils, may induce thrombus formation within an aneurysm."	3.70	Detection of microemboli distal to cerebral aneurysms before and after therapeutic embolization. ( Berlit, P; Henkes, H; Klötzsch, C; Kühne, D; Nahser, HC, 1998)
"This follow-up study was designed to evaluate whether the use of aspirin either before or after aneurysm rupture affects the occurrence of delayed cerebral ischemia."	3.69	Aspirin and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. ( Juvela, S, 1995)
"Flow diversion for ruptured aneurysms under SAPT with coated stents is feasible."	3.01	A Systematic Literature Review and Meta-Analysis of the Treatment of Ruptured Intracranial Aneurysms with Hydrophilic Polymer and Phosphorylcholine-Coated Flow Diverters Under Single Antiplatelet Therapy. ( Gawlitza, M; Kaiser, DPO; Klisch, J; Linn, J; Lobsien, D; Pierot, L, 2023)
"Tiny cerebral aneurysms can be safely and effectively treated with appropriate endovascular approaches based on aneurysm specific morphology, especially neck size and neck-to-dome ratio."	2.87	Tiny Cerebral Aneurysms Can Be Treated Safely and Effectively with Low-Profile Visualized Intraluminal Support Stent-Assisted Coiling or Coiling Alone. ( Gao, BL; Li, L; Li, TX; Xu, GQ; Yang, BW, 2018)
"Myxomas are slowly growing benign neoplasms and represent the most common tumor of the heart."	2.61	Delayed intracranial aneurysm formation after cardiac myxoma resection: Report of two cases and review of the literature. ( Knopman, J; Patsalides, A; Pierre Gobin, Y; Santillan, A, 2019)
" Dosing for neuroendovascular conditions is often extrapolated from the cardiac literature, although outcomes in cardiac patients may not be relevant to neurologic patients, making prophylactic treatment recommendations challenging for these patients."	2.61	Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel-Hyporesponsive Patients. ( Barra, ME; Berger, K; Brophy, GM; Tesoro, EP, 2019)
"Aspirin is a potent inhibitor of cyclooxygenase-2 (COX), which plays a critical role in the expression of immune modulators known to contribute to cerebral aneurysm formation and rupture."	2.52	Potential role of aspirin in the prevention of aneurysmal subarachnoid hemorrhage. ( Chalouhi, N; Ding, D; Hasan, DM; Starke, RM, 2015)
"Eight patients with eight middle cerebral artery aneurysms were included in this study."	1.56	Endovascular treatment of complex middle cerebral artery aneurysms using TuBridge flow diverters. ( Guo, N; Liang, F; Liao, B; Luo, L; Ou, S; Qi, T; Xiao, W; Yang, Y; Zhang, G, 2020)
"The ruptured aneurysms were four saccular, two blister-like and one dissecting, six in the anterior and one in posterior circulation."	1.56	Flow diverter stents with hydrophilic polymer coating for the treatment of acutely ruptured aneurysms using single antiplatelet therapy: Preliminary experience. ( Carriero, A; Cossandi, C; Del Sette, B; Galbiati, A; Guzzardi, G; Paladini, A; Stanca, C, 2020)
"Ticagrelor is an antiplatelet agent with low resistance rates but unknown efficacy and safety in neurovascular patients."	1.51	Dual Antiplatelet Therapy Combining Aspirin and Ticagrelor for Intracranial Stenting Procedures: A Retrospective Single Center Study of 154 Consecutive Patients With Unruptured Aneurysms. ( Amelot, A; Angoulvant, D; Bibi, R; Gruel, Y; Herbreteau, D; Janot, K; Narata, AP, 2019)
"Flow diversion has revolutionised the treatment of intracranial aneurysms, and the Pipeline Embolization Device (PED) remains the only flow diverter (FD) approved in the USA."	1.46	First US experience with Pipeline Flex with Shield Technology using aspirin as antiplatelet monotherapy. ( Aguilar-Salinas, P; Brasiliense, LB; Hanel, RA; Sauvageau, E, 2017)
"Takayasu arteritis was diagnosed subsequently."	1.46	Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis. ( Herath, HMMTB; Pahalagamage, SP; Senanayake, S; Withana, D, 2017)
"Flow diversion is increasingly used to treat intracranial aneurysms."	1.43	A New Protocol for Anticoagulation With Tirofiban During Flow Diversion. ( Chalouhi, N; Daou, B; Hasan, DM; Jabbour, P; Shields, B; Starke, RM, 2016)
"Procedure-related thromboembolism is a major limitation of coil embolization, but the relationship between thromboembolic infarction and antiplatelet resistance is poorly understood."	1.43	Association between Postprocedural Infarction and Antiplatelet Drug Resistance after Coiling for Unruptured Intracranial Aneurysms. ( Hong, SC; Jeon, P; Jo, KI; Kim, JS; Kim, KH; Kim, MS; Yeon, JY, 2016)
"The rate of cerebral aneurysm rupture was similar in male mice receiving aspirin and 15-hydroxyprostaglandin dehydrogenase inhibitor compared with females receiving aspirin and 15-hydroxyprostaglandin dehydrogenase agonist, signaling a reversal of the sex-differential response to aspirin."	1.43	Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. ( Brown, RD; Chalouhi, N; Correa, T; Hasan, DM; Jabbour, PM; Starke, RM; Torner, JC; Zanaty, M, 2016)
" All patients received low-molecular-weight heparin in prophylactic dosage starting 24 hours after aneurysm treatment."	1.42	Ventriculostomy-Related Hemorrhage After Treatment of Acutely Ruptured Aneurysms: The Influence of Anticoagulation and Antiplatelet Treatment. ( Bruder, M; El-Fiki, A; Güresir, E; Konczalla, J; Lescher, S; Schuss, P; Seifert, V; Vatter, H, 2015)
"Aspirin plays a key role in preventing IPS."	1.42	In-Pipeline Stenosis: Incidence, Predictors, and Clinical Outcomes. ( Barros, G; Chalouhi, N; Daou, B; Gonzalez, LF; Hasan, D; Jabbour, P; Judy, B; Kung, D; Polifka, A; Rosenwasser, RH; Starke, RM; Tjoumakaris, S, 2015)
"In our preliminary experience, treatment of ruptured aneurysms with the PED was associated with low complication rates, high occlusion rates, and favorable outcomes."	1.42	Treatment of ruptured intracranial aneurysms with the pipeline embolization device. ( Ajiboye, N; Chalouhi, N; Hann, S; Hasan, D; Jabbour, P; Rosenwasser, RH; Tjoumakaris, S; Whiting, A; Zanaty, M, 2015)
"In the treatment of ruptured dissecting aneurysms, parent vessel occlusion (PVO) with aneurysm is common."	1.42	[Stent-Assisted Coil Embolization of a Dissecting Aneurysm of the Posterior Cerebral Artery: A Case Report]. ( Date, I; Haruma, J; Hattori, Y; Kobayashi, K; Muneda, K; Sasaki, T; Sugiu, K; Yoshida, H; Yukiue, T, 2015)
"Aspirin-treated rats exhibited a significant decrease in degradation of internal elastic lamina (IEL), medial layer thinning, CA size and macrophages infiltration with reduced expression of MMP-2 and 9 compared with rats in the CA group."	1.42	Aspirin Inhibits Degenerative Changes of Aneurysmal Wall in a Rat Model. ( Dong, JF; Jiang, R; Li, S; Liu, L; Tian, Y; Wang, D; Wei, H; Zhang, J; Zhou, Z, 2015)
"Intracranial aneurysms were induced in wild-type and mPGES-1 knockout (mPGES-1 KO) mice by using a combination of deoxycorticosterone acetate-salt-induced hypertension and intracranial injection of elastase in the basal cistern."	1.42	Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. ( Faraci, FM; Granja, MF; Harty, JT; Hasan, DM; Heistad, DD; Kung, DK; Mitchell, IJ; Peña Silva, RA; Pewe, LL, 2015)
"No new intracranial hemorrhages were observed in patients not receiving dual antiplatelet therapy."	1.39	Risk of hemorrhagic complication associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on dual antiplatelet therapy. ( Bulsara, KR; Chalouhi, N; Hasan, DM; Howard, M; Jabbour, P; Kung, DK; Mahaney, KB; Smietana, J; Viljoen, S, 2013)
"Treatment of intracranial fusiform aneurysms is complex and controversial, and is associated with high morbidity and mortality rates."	1.39	Using Leo Plus stent as flow diverter and endoluminal remodeling in endovascular treatment of intracranial fusiform aneurysms. ( Ageitos, M; Arias-Rivas, S; Blanco, M; Castiñeira-Mourenza, JA; Masso, A; Pumar, JM; Rodríguez-Yáñez, M; Vazquez-Herrero, F, 2013)
"Four patients (23."	1.39	Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment. ( Alaraj, A; Aletich, VA; Amin-Hanjani, S; Carlson, AP; Charbel, FT, 2013)
"The determinants of subarachnoid hemorrhage (SAH) volume and an atypical pattern of blood are not clear."	1.38	Predictors of hemorrhage volume and disability after perimesencephalic subarachnoid hemorrhage. ( Batjer, HH; Bendok, BR; Maas, MB; Naidech, AM; Nemeth, AJ; Rosenberg, NF, 2012)
"To clarify the frequency of Japanese patients who are resistant to antiplatelet agents, and then clarify correlations between resistance and thromboembolic adverse events in neurointervention."	1.38	[Resistance to antiplatelet agents assessed by a point-of-care platelet function test and thromboembolic adverse events in neurointervention]. ( Asai, T; Haraguchi, K; Izumi, T; Matsubara, N; Miyachi, S; Naito, T; Wakabayashi, T; Yamanouchi, T, 2012)
"Aspirin was restarted on the first postoperative day and clopidogrel was restarted on the second postoperative day."	1.38	Perioperative management of a neurosurgical patient requiring antiplatelet therapy. ( Gregory Thompson, B; Rohatgi, P; Than, KD; Wilson, TJ, 2012)
"Losartan is known to inhibit transforming growth factor β signaling and may be a specific modulator of disease expression in this syndrome."	1.37	Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. ( Levinson, JR; MacRae, CA; Nahed, BV; Naunheim, MR; Ogilvy, CS; Walcott, BP, 2011)
"Delayed intracerebral hemorrhage (DIH) was observed more often in the routine antiplatelet group (2/9 cases, 22."	1.37	Delayed intracranial hemorrhage associated with antiplatelet therapy in stent-assisted coil embolized cerebral aneurysms. ( Chai, WN; He, ZH; Sun, XC; Wu, HT; Zhang, XD; Zhu, J, 2011)
"Tuberous sclerosis is an autosomal dominant inherited phakomatosis."	1.36	[Tuberous sclerosis and intracranial aneurysms: a rare association]. ( Aissi, M; Boughammoura-Bouatay, A; Frih-Ayed, M; Jerbi-Ommezzine, S; Sfar, MH; Younes-Mhenni, S, 2010)
"Two hundred and sixty-one cerebral aneurysms were treated in 247 patients by endovascular coil embolization from January 2001 to September 2004."	1.33	Intravenous administration of acetylsalicylic acid during endovascular treatment of cerebral aneurysms reduces the rate of thromboembolic events. ( Buhk, JH; Fiehler, J; Goebell, E; Grzyska, U; Kucinski, T; Ries, T; Zeumer, H, 2006)

Research

Studies (145)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Effectiveness - Aneurysm Occlusion

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.69)	18.7374
1990's	6 (4.14)	18.2507
2000's	12 (8.28)	29.6817
2010's	92 (63.45)	24.3611
2020's	34 (23.45)	2.80

Authors	Studies
Guo, Y	1
Guo, XM	1
Zhao, K	1
Yang, MF	1
Hosoo, H	1
Ishikawa, E	1
Tsuruta, W	1
Sato, M	1
Ito, Y	1
Hayakawa, M	2
Takigawa, T	1
Marushima, A	1
Suzuki, K	1
Hyodo, A	1
Matsumaru, Y	1
Hendrix, P	1
Griessenauer, CJ	2
Schirmer, CM	1
Chien, SC	1
Chen, CC	1
Chen, CT	1
Wang, AY	1
Hsieh, PC	1
Yeap, MC	1
Liu, ZH	1
Wang, YC	1
Liu, YT	1
Räisänen, S	1
Huttunen, J	1
Huuskonen, TJ	1
von Und Zu Fraunberg, M	1
Koivisto, T	1
Jääskeläinen, JE	1
Lindgren, A	1
Frösen, J	1
Lee, SH	1
Choi, HH	1
Jang, KM	1
Nam, TK	2
Byun, JS	2
Young, CC	1
Bass, DI	1
Cruz, MJ	1
Carroll, K	1
Vanent, KN	1
Lee, C	1
Sen, RD	1
Feroze, AH	1
Williams, JR	1
Levy, S	1
McCray, D	1
Kelly, CM	1
Barber, J	1
Kim, LJ	1
Levitt, MR	1
Wang, B	1
Liu, S	1
Na, SJ	1
Peng, Y	1
Ding, WB	1
Zhao, LB	1
Jia, ZY	1
Shi, HB	1
Feng, Q	1
Shimizu, K	1
Aoki, T	1
Etminan, N	2
Hackenberg, KAM	2
Tani, S	1
Imamura, H	1
Kataoka, H	1
Sakai, N	1
Gawlitza, M	3
Klisch, J	3
Kaiser, DPO	3
Linn, J	3
Pierot, L	4
Lobsien, D	3
Fuga, M	2
Tanaka, T	2
Tachi, R	2
Tomoto, K	2
Wachi, R	2
Teshigawara, A	2
Ishibashi, T	3
Hasegawa, Y	2
Murayama, Y	3
Papaxanthos, J	1
Cagnazzo, F	1
Collemiche, FL	1
Barreau, X	1
Radu, RA	1
Gariel, F	1
Derraz, I	1
Gascou, G	1
Riquelme, C	1
Ferreira, I	1
Lefevre, PH	1
Berge, J	1
Costalat, V	1
Dargazanli, C	1
Marnat, G	1
Jabbarli, R	1
Darkwah Oppong, M	1
Chihi, M	1
Dinger, TF	1
Said, M	1
Rodemerk, J	1
Dammann, P	1
Schmidt, B	1
Deuschl, C	1
Guberina, N	1
Wrede, KH	1
Sure, U	1
Hudson, JS	1
Marincovich, AJ	1
Roa, JA	2
Zanaty, M	6
Samaniego, EA	2
Hasan, DM	13
Kan, I	1
Sakuta, K	1
Fujimura, S	1
Yuki, I	1
Kaku, S	1
Kodama, T	1
Kato, N	1
Nishimura, K	1
Aoki, K	1
Sasaki, Y	1
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Kung, DK	6
Starke, RM	7
Torner, JC	3
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Trial	Phase	Enrollment	Study Type	Start Date	Status
The Clinical Benefit and Risk of Oral Aspirin for Patients Who Have Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia[NCT02846259]		2,135 participants (Anticipated)	Observational [Patient Registry]	2016-01-31	Recruiting
Aspirin Treatment for Small Unruptured InTracranial Aneurysms With Ischemic cereBrovascuLar diseasE (AT-SUITABLE): a Phase 3, Multicenter, Prospective, Randomized, Open-label, Blinded-endpoint Controlled Trial[NCT05907902]	Phase 3	824 participants (Anticipated)	Interventional	2023-07-01	Not yet recruiting
Effect of Heparinization on Intracranial Aneurysm[NCT05749393]		90 participants (Anticipated)	Interventional	2023-04-30	Recruiting
Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms[NCT02638701]	Phase 1/Phase 2	8 participants (Anticipated)	Interventional	2018-07-01	Enrolling by invitation
Aspirin as a Promising Agent to Attenuate Inflammation in the Wall of Human Cerebral Aneurysms[NCT01710072]	Phase 1	11 participants (Actual)	Interventional	2011-08-31	Completed
Comparison of Dual-Antiplatelet and Triple-Antiplatelet Preparation Using P2Y12 Assay in Patients With High On-Treatment Platelet Reactivity Undergoing Stent-Assisted Coil Embolization for An Unruptured Intracranial Aneurysm[NCT03581409]	Phase 4	198 participants (Actual)	Interventional	2018-10-24	Completed
Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling of Unruptured Intracranial Aneurysms: A Prospective Randomized Multicenter Trial[NCT05257824]	Phase 4	528 participants (Anticipated)	Interventional	2022-06-23	Recruiting
Improving Outcome in Subarachnoid Hemorrhage wIth Nadroparine[NCT04507178]	Phase 2	100 participants (Anticipated)	Interventional	2022-02-02	Recruiting
Pipeline Flex With SHield Technology Embolization - An International MulticEnter ObservationaL Post Market StuDy of Treated Intra Cranial Aneurysms (SHIELD)[NCT02719522]		205 participants (Actual)	Observational	2016-03-31	Completed
the Treatment of Intracranial Aneurysm Using Different Types of Stents Assisted Embolization :Trials of Clinical Curative Effect, Follow-up Study and Hemodynamics[NCT03387995]		2,000 participants (Anticipated)	Observational	2016-09-01	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Percentage (%) of Participants who have achieved complete aneurysm occlusion (defined as Raymond-Roy grade 1) without significant parent artery stenosis (≤ 50%) or retreatment of the target aneurysm post-procedure (1-year) (NCT02719522)
Timeframe: 1 year

Effectiveness - Deployment Rate

Intervention	percentage of patients (Number)
Intention to Treat (ITT)	71.67

"Percentage (%) of Participants who have had a successful deployment of the device at the target site.~A device is considered properly deployed when it covers the entire length of the aneurysm neck." (NCT02719522)
Timeframe: 1 year

Safety - Intracerebral Hemorrhage (ICH)

Intervention	Participants (Count of Participants)
Intention to Treat (ITT)	200

Percentage (%) of Participants who experienced a delayed intracerebral hemorrhage > 30 days post-procedure (NCT02719522)
Timeframe: 1 year

Safety - Stroke/Death Occurrence

Intervention	Participants (Count of Participants)
Intention to Treat (ITT)	0

Percentage (%) of Participants who experienced a major stroke in the territory supplied by the treated artery or neurological death post-procedure (1-year) (NCT02719522)
Timeframe: 1 year

Safety - Stroke/Death Occurrence - 30 Days

Intervention	percentage of patients with event (Number)
Intention to Treat (ITT)	3.23

Percentage (%) of Participants who experienced a major stroke in the territory supplied by the treated artery or neurological death at 30 days post-procedure due to procedural complications (NCT02719522)
Timeframe: 30 days

Article	Year
Aspirin and growth, rupture of unruptured intracranial aneurysms: A systematic review and meta-analysis. Clinical neurology and neurosurgery, 2021, Volume: 209 Topics: Aneurysm, Ruptured; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Intracranial Aneurysm;	2021
Associations Between Drug Treatments and the Risk of Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-analysis. Translational stroke research, 2023, Volume: 14, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Biguanides; Humans; Hydro	2023
A Systematic Literature Review and Meta-Analysis of the Treatment of Ruptured Intracranial Aneurysms with Hydrophilic Polymer and Phosphorylcholine-Coated Flow Diverters Under Single Antiplatelet Therapy. World neurosurgery, 2023, Volume: 170 Topics: Aneurysm, Ruptured; Aspirin; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracrania	2023
A Systematic Literature Review and Meta-Analysis of the Treatment of Ruptured Intracranial Aneurysms with Hydrophilic Polymer and Phosphorylcholine-Coated Flow Diverters Under Single Antiplatelet Therapy. World neurosurgery, 2023, Volume: 170 Topics: Aneurysm, Ruptured; Aspirin; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracrania	2023
A Systematic Literature Review and Meta-Analysis of the Treatment of Ruptured Intracranial Aneurysms with Hydrophilic Polymer and Phosphorylcholine-Coated Flow Diverters Under Single Antiplatelet Therapy. World neurosurgery, 2023, Volume: 170 Topics: Aneurysm, Ruptured; Aspirin; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracrania	2023
A Systematic Literature Review and Meta-Analysis of the Treatment of Ruptured Intracranial Aneurysms with Hydrophilic Polymer and Phosphorylcholine-Coated Flow Diverters Under Single Antiplatelet Therapy. World neurosurgery, 2023, Volume: 170 Topics: Aneurysm, Ruptured; Aspirin; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracrania	2023
A meta-analysis of aspirin and subarachnoid hemorrhage in patients with intracranial aneurysms yields different results to the general population. International journal of stroke : official journal of the International Stroke Society, 2022, Volume: 17, Issue:3 Topics: Aneurysm, Ruptured; Aspirin; Humans; Intracranial Aneurysm; Prospective Studies; Stroke; Subarachnoi	2022
Antiplatelet therapy and the risk of ischemic and hemorrhagic complications associated with Pipeline embolization of cerebral aneurysms: a systematic review and pooled analysis. Journal of neurointerventional surgery, 2019, Volume: 11, Issue:4 Topics: Adult; Aged; Aspirin; Blood Vessel Prosthesis; Brain Ischemia; Cerebral Hemorrhage; Embolization, Th	2019
Unruptured Intracranial Aneurysms. Stroke, 2018, Volume: 49, Issue:9 Topics: Aneurysm, Ruptured; Antihypertensive Agents; Aspirin; Cyclooxygenase Inhibitors; Disease Management;	2018
Delayed intracranial aneurysm formation after cardiac myxoma resection: Report of two cases and review of the literature. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019, Volume: 25, Issue:2 Topics: Aged; Anticoagulants; Aspirin; Cerebral Angiography; Female; Heart Neoplasms; Humans; Intracranial A	2019
Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel-Hyporesponsive Patients. Pharmacotherapy, 2019, Volume: 39, Issue:3 Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Endovascular Procedures; Humans; Intracranial Aneur	2019
Nonsteroidal Anti-Inflammatory Drugs: A Potential Pharmacological Treatment for Intracranial Aneurysm. Cerebrovascular diseases extra, 2019, Volume: 9, Issue:1 Topics: Animals; Aspirin; Cerebral Arteries; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dilatat	2019
Anti-thrombogenic coatings for devices in neurointerventional surgery: Case report and review of the literature. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2019, Volume: 25, Issue:6 Topics: Adult; Angiography, Digital Subtraction; Aspirin; Cerebral Angiography; Coated Materials, Biocompati	2019
Potential role of aspirin in the prevention of aneurysmal subarachnoid hemorrhage. Cerebrovascular diseases (Basel, Switzerland), 2015, Volume: 39, Issue:5-6 Topics: Aneurysm, Ruptured; Animals; Aspirin; Brain; Humans; Intracranial Aneurysm; Intramolecular Oxidoredu	2015
Antiplatelet therapy in neuroendovascular therapeutics. Neurosurgery clinics of North America, 2005, Volume: 16, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Intracranial Aneurysm	2005
[Intraaneurysmal embolization for cerebral aneurysms]. No shinkei geka. Neurological surgery, 2000, Volume: 28, Issue:6 Topics: Anesthesia, General; Anticoagulants; Aspirin; Cerebral Arteries; Embolization, Therapeutic; Fibrinol	2000

Article	Year
Tiny Cerebral Aneurysms Can Be Treated Safely and Effectively with Low-Profile Visualized Intraluminal Support Stent-Assisted Coiling or Coiling Alone. World neurosurgery, 2018, Volume: 113 Topics: Adult; Aged; Aneurysm, Ruptured; Aspirin; Clopidogrel; Embolization, Therapeutic; Endovascular Proce	2018
Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results. Journal of the American Heart Association, 2013, Feb-22, Volume: 2, Issue:1 Topics: Aged; Angiography, Digital Subtraction; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebral A	2013
Magnesium and aspirin treatment in patients with subarachnoid haemorrhage. Comparison of effects after endovascular and neurosurgical aneurysm occlusion. Journal of neurology, 2009, Volume: 256, Issue:2 Topics: Aspirin; Brain Ischemia; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Magnesium	2009
Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms. Neurosurgery, 2009, Volume: 65, Issue:6 Topics: Adult; Aged; Aspirin; Blood Vessel Prosthesis; Cerebral Angiography; Clopidogrel; Embolization, Ther	2009
Antiplatelet therapy for prevention of thromboembolic complications associated with coil embolization of unruptured cerebral aneurysms. Drugs in R&D, 2012, Mar-01, Volume: 12, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeuti	2012
Randomized controlled trial of acetylsalicylic acid in aneurysmal subarachnoid hemorrhage: the MASH Study. Stroke, 2006, Volume: 37, Issue:9 Topics: Aneurysm, Ruptured; Aspirin; Drug Administration Schedule; Female; Humans; Intracranial Aneurysm; Ma	2006
Double-blind trial of aspirin in patient receiving tranexamic acid for subarachnoid hemorrhage. Acta neurochirurgica, 1982, Volume: 62, Issue:3-4 Topics: Angiography; Aphasia; Aspirin; Double-Blind Method; Female; Hemiplegia; Humans; Intracranial Aneurys	1982

Article	Year
Antiplatelet Therapy and Periprocedural Risk Factor Analysis for Pipeline Embolization Device Treatment of Unruptured Internal Carotid Artery Aneurysms: A Retrospective, Multicenter Analysis. World neurosurgery, 2022, Volume: 157 Topics: Adult; Aged; Aspirin; Carotid Artery, Internal; Clopidogrel; Dual Anti-Platelet Therapy; Embolizatio	2022
Not quite time to stop testing aspirin response yet? Journal of neurointerventional surgery, 2022, Volume: 14, Issue:7 Topics: Aspirin; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Stents	2022
Ticagrelor versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2022, Volume: 28, Issue:5 Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet Aggregation	2022
Risk factor management matters more than pharmaceutical cyclooxygenase-2 inhibition in the prevention of de novo intracranial aneurysms. European journal of neurology, 2022, Volume: 29, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Din	2022
Safety and Efficacy of Low-dose Prasugrel in the Endovascular Treatment of Unruptured Aneurysms in the Elders (≥ 75 Years). Clinical neuroradiology, 2023, Volume: 33, Issue:1 Topics: Aged; Aspirin; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracranial Aneurysm; Pl	2023
Clopidogrel hyper-response increases peripheral hemorrhagic complications without increasing intracranial complications in endovascular aneurysm treatments requiring dual antiplatelet therapy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2022, Volume: 105 Topics: Aortic Aneurysm, Abdominal; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Endovascular	2022
Effects of endovascular treatment and prognostic factors for recovery of oculomotor nerve palsy caused by posterior communicating artery aneurysms: a multi-center retrospective analysis. BMC neurology, 2022, Oct-08, Volume: 22, Issue:1 Topics: Aspirin; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracranial Aneurysm; Oculomot	2022
Thromboelastography 6s for assessment of platelet function during coil embolization of unruptured intracranial aneurysms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023, Volume: 32, Issue:2 Topics: Adenosine Diphosphate; Aspirin; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet A	2023
Thromboelastography 6s for assessment of platelet function during coil embolization of unruptured intracranial aneurysms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023, Volume: 32, Issue:2 Topics: Adenosine Diphosphate; Aspirin; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet A	2023
Thromboelastography 6s for assessment of platelet function during coil embolization of unruptured intracranial aneurysms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023, Volume: 32, Issue:2 Topics: Adenosine Diphosphate; Aspirin; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet A	2023
Thromboelastography 6s for assessment of platelet function during coil embolization of unruptured intracranial aneurysms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023, Volume: 32, Issue:2 Topics: Adenosine Diphosphate; Aspirin; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet A	2023
Ticagrelor versus clopidogrel dual antiplatelet therapy for unruptured intracranial aneurysms treated with flowdiverter. Journal of neuroradiology = Journal de neuroradiologie, 2023, Volume: 50, Issue:3 Topics: Aspirin; Clopidogrel; Hemorrhage; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Re	2023
Regular medication as a risk factor for intracranial aneurysms: A comparative case-control study. European stroke journal, 2023, Volume: 8, Issue:1 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Calcium Channel Bloc	2023
Aspirin and Intracranial Aneurysms. Stroke, 2019, Volume: 50, Issue:9 Topics: Aneurysm, Ruptured; Animals; Aspirin; Female; Humans; Intracranial Aneurysm; Male; Subarachnoid Hemo	2019
Preoperative Light Transmission Aggregometry Values Predict for Thromboembolic Complications After Stent-Assisted Coil Embolization. World neurosurgery, 2020, Volume: 134 Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Endovascular Procedures; Female; Hematoma; Hemorrha	2020
Is Aspirin a Worthy Candidate in Preventing Intracranial Aneurysm Rupture? World neurosurgery, 2020, Volume: 136 Topics: Aneurysm, Ruptured; Aspirin; Fibrinolytic Agents; Humans; Intracranial Aneurysm; Subarachnoid Hemorr	2020
Decreased contrast enhancement on high-resolution vessel wall imaging of unruptured intracranial aneurysms in patients taking aspirin. Journal of neurosurgery, 2020, Mar-06, Volume: 134, Issue:3 Topics: Aged; Anterior Cerebral Artery; Aspirin; Basilar Artery; Blood Vessels; Contrast Media; Female; Huma	2020
Failure of platelet function analyser 200 to demonstrate clinical clopidogrel resistance in a patient undergoing intracranial vascular stenting. BMJ case reports, 2020, Mar-12, Volume: 13, Issue:3 Topics: Aged; Aspirin; Clopidogrel; Diagnosis, Differential; Drug Resistance; Humans; Intracranial Aneurysm;	2020
Endovascular treatment of complex middle cerebral artery aneurysms using TuBridge flow diverters. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2020, Volume: 26, Issue:5 Topics: Adult; Aspirin; Cerebral Angiography; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combinat	2020
Flow diverter stents with hydrophilic polymer coating for the treatment of acutely ruptured aneurysms using single antiplatelet therapy: Preliminary experience. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2020, Volume: 26, Issue:5 Topics: Aneurysm, Ruptured; Angiography, Digital Subtraction; Aspirin; Cerebral Angiography; Coated Material	2020
Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study. Stroke, 2020, Volume: 51, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angiography, Digital Subtraction; Anti-Inflammat	2020
Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study. Stroke, 2020, Volume: 51, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angiography, Digital Subtraction; Anti-Inflammat	2020
Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study. Stroke, 2020, Volume: 51, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angiography, Digital Subtraction; Anti-Inflammat	2020
Aspirin and Growth of Small Unruptured Intracranial Aneurysm: Results of a Prospective Cohort Study. Stroke, 2020, Volume: 51, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angiography, Digital Subtraction; Anti-Inflammat	2020
Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms. Neurology, 2021, 01-05, Volume: 96, Issue:1 Topics: Aged; Aneurysm, Ruptured; Aspirin; Cohort Studies; Female; Humans; Intracranial Aneurysm; Male; Midd	2021
Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms. Neurology, 2021, 01-05, Volume: 96, Issue:1 Topics: Aged; Aneurysm, Ruptured; Aspirin; Cohort Studies; Female; Humans; Intracranial Aneurysm; Male; Midd	2021
Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms. Neurology, 2021, 01-05, Volume: 96, Issue:1 Topics: Aged; Aneurysm, Ruptured; Aspirin; Cohort Studies; Female; Humans; Intracranial Aneurysm; Male; Midd	2021
Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms. Neurology, 2021, 01-05, Volume: 96, Issue:1 Topics: Aged; Aneurysm, Ruptured; Aspirin; Cohort Studies; Female; Humans; Intracranial Aneurysm; Male; Midd	2021
Differences in thromboembolism after stent-assisted coiling for unruptured aneurysms between aspirin plus clopidogrel and ticagrelor. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2020, Volume: 82, Issue:Pt A Topics: Adult; Aged; Aspirin; Clopidogrel; Diffusion Magnetic Resonance Imaging; Embolization, Therapeutic;	2020
Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing. World neurosurgery, 2021, Volume: 148 Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Disease Models, Animal; Disease P	2021
Impact of acetylsalicylic acid in patients undergoing cerebral aneurysm surgery - should the neurosurgeon really worry about it? Neurosurgical review, 2021, Volume: 44, Issue:5 Topics: Aspirin; Humans; Intracranial Aneurysm; Neurosurgeons; Platelet Aggregation Inhibitors; Retrospectiv	2021
Aspirin monotherapy in the treatment of distal intracranial aneurysms with a surface modified flow diverter: a pilot study. Journal of neurointerventional surgery, 2021, Volume: 13, Issue:4 Topics: Adult; Aged; Aspirin; Brain Ischemia; Embolization, Therapeutic; Endovascular Procedures; Female; Hu	2021
Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture. PloS one, 2021, Volume: 16, Issue:2 Topics: Aged; Aneurysm, Ruptured; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Therapy, Combinatio	2021
Should We be Prophylactically Treating All Small Unruptured Intracranial Aneurysms With Aspirin? World neurosurgery, 2021, Volume: 146 Topics: Aspirin; Cyclooxygenase Inhibitors; Humans; Intracranial Aneurysm; Treatment Outcome	2021
Reduction of thromboembolic complications during the endovascular treatment of unruptured aneurysms by employing a tailored dual antiplatelet regimen using aspirin and prasugrel. Journal of neurointerventional surgery, 2021, Volume: 13, Issue:11 Topics: Aspirin; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Re	2021
Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits. Journal of neurointerventional surgery, 2022, Volume: 14, Issue:2 Topics: Aneurysm; Animals; Aspirin; Disease Models, Animal; Inflammation; Intracranial Aneurysm; Pancreatic	2022
The relationship between the level of vitamin D and ruptured intracranial aneurysms. Scientific reports, 2021, 06-04, Volume: 11, Issue:1 Topics: Adult; Aged; Aneurysm, Ruptured; Aspirin; Case-Control Studies; Cerebral Angiography; China; Comorbi	2021
Quantitative Computed Tomographic Volumetry after Treatment of a Giant Intracranial Aneurysm with a Pipeline Embolization Device. Yonsei medical journal, 2017, Volume: 58, Issue:3 Topics: Adult; Aged; Anticoagulants; Aspirin; Carotid Artery, Internal; Embolization, Therapeutic; Female; H	2017
Malignant stroke in a ticagrelor non-responder as a complication following aneurysm treatment with the Pipeline Embolization Device™. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2017, Volume: 23, Issue:3 Topics: Adenosine; Aged; Aspirin; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Embolization,	2017
First US experience with Pipeline Flex with Shield Technology using aspirin as antiplatelet monotherapy. BMJ case reports, 2017, May-04, Volume: 2017 Topics: Aneurysm, Ruptured; Angiography; Aspirin; Diffusion Magnetic Resonance Imaging; Embolization, Therap	2017
Numerous Fusiform and Saccular Cerebral Aneurysms in Central Nervous System Lupus Presenting with Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2017, Volume: 26, Issue:7 Topics: Adult; Antihypertensive Agents; Aspirin; Brain Ischemia; Cerebral Angiography; Diffusion Magnetic Re	2017
Novel use of flow diversion for the treatment of aneurysms associated with arteriovenous malformations. Neurosurgical focus, 2017, Volume: 42, Issue:6 Topics: Adult; Arteriovenous Malformations; Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans;	2017
Gradual remodelling of the vertebrobasilar circulation with reconstructive treatment of a symptomatic fusiform basilar artery aneurysm. Acta neurologica Belgica, 2017, Volume: 117, Issue:4 Topics: Aspirin; Cerebrovascular Circulation; Fibrinolytic Agents; Humans; Image Processing, Computer-Assist	2017
Complete ophthalmoplegia, complete ptosis and dilated pupil due to internal carotid artery dissection: as the first manifestation of Takayasu arteritis. BMC cardiovascular disorders, 2017, 07-25, Volume: 17, Issue:1 Topics: Adult; Angiography, Digital Subtraction; Aortic Dissection; Aspirin; Blepharoptosis; Carotid Artery	2017
Sex Differential in 15-Hydroxyprostaglandin Dehydrogenase Levels in the Lumen of Human Intracranial Aneurysms. Journal of the American Heart Association, 2017, Oct-17, Volume: 6, Issue:10 Topics: Adult; Aged; Aspirin; Biomarkers; Cardiovascular Agents; Embolization, Therapeutic; Female; Humans;	2017
Continuous Acetylsalicylic Acid Treatment Does Not Influence Bleeding Pattern or Outcome of Aneurysmal Subarachnoid Hemorrhage: A Matched-Pair Analysis. World neurosurgery, 2018, Volume: 113 Topics: Aged; Aneurysm, Ruptured; Aspirin; Cerebral Hemorrhage; Cerebral Infarction; Female; Follow-Up Studi	2018
Self-Reported Headaches in Patients with Unruptured Intracranial Aneurysms Treated with the Pipeline Embolization Device. World neurosurgery, 2018, Volume: 113 Topics: Adult; Aged; Aged, 80 and over; Angiography, Digital Subtraction; Aspirin; Clopidogrel; Comorbidity;	2018
Dual Antiplatelet Therapy Combining Aspirin and Ticagrelor for Intracranial Stenting Procedures: A Retrospective Single Center Study of 154 Consecutive Patients With Unruptured Aneurysms. Neurosurgery, 2019, 01-01, Volume: 84, Issue:1 Topics: Aspirin; Dual Anti-Platelet Therapy; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors;	2019
Treatment of Unruptured, Saccular, Anterior Choroidal Artery Aneurysms with Flow Diversion : A Single Centre Experience. Clinical neuroradiology, 2019, Volume: 29, Issue:3 Topics: Adult; Aged; Aspirin; Cerebral Arteries; Clopidogrel; Endovascular Procedures; Female; Humans; Intra	2019
Prevention Effect of Antiplatelets on Aneurysm Rupture in a Mouse Intracranial Aneurysm Model. Cerebrovascular diseases (Basel, Switzerland), 2018, Volume: 45, Issue:3-4 Topics: Aneurysm, Ruptured; Animals; Aspirin; Cerebral Arteries; Cilostazol; Cyclooxygenase 2; Cyclooxygenas	2018
Novel microguidewire-assist (MGA) manoeuver for coil embolisation of an unruptured middle cerebral artery aneurysm. BMJ case reports, 2018, Aug-27, Volume: 2018 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catheterization; Cerebral Angiography; Clopi	2018
Precision of VerifyNow P2Y12 Assessment of Clopidogrel Response in Patients Undergoing Cerebral Aneurysm Flow Diversion. Neurosurgery, 2019, 10-01, Volume: 85, Issue:4 Topics: Aged; Aspirin; Blood Coagulation Tests; California; Clopidogrel; Embolization, Therapeutic; Female;	2019
Transient in-stent stenosis at mid-term angiographic follow-up in patients treated with SILK flow diverter stents: incidence, clinical significance and long-term follow-up. Journal of neurointerventional surgery, 2019, Volume: 11, Issue:2 Topics: Adult; Aged; Angiography, Digital Subtraction; Aspirin; Cerebral Angiography; Female; Follow-Up Stud	2019
Unusual right internal carotid artery supraclinoid segment fenestration associated with multiple aneurysms treated with flow diversion and coiling. BMJ case reports, 2018, Sep-10, Volume: 2018 Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Clopidogrel; Endovascular Procedures; Fe	2018
Preliminary experience with the use of low profile visualized intraluminal support device in basilar artery for aneurysm treatment. Journal of neurointerventional surgery, 2019, Volume: 11, Issue:4 Topics: Adult; Aged; Aspirin; Basilar Artery; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic;	2019
Early detection of vertebral artery dissection. BMJ case reports, 2018, Nov-28, Volume: 11, Issue:1 Topics: Adult; Aftercare; Aspirin; Computed Tomography Angiography; Diagnosis, Differential; Early Diagnosis	2018
Testing bioresorbable stent feasibility in a rat aneurysm model. Journal of neurointerventional surgery, 2019, Volume: 11, Issue:10 Topics: Absorbable Implants; Animals; Aspirin; Embolization, Therapeutic; Feasibility Studies; Intracranial	2019
Bridging antiplatelet therapy with cangrelor in patients with recent intracranial stenting undergoing invasive procedures: a prospective case series. British journal of anaesthesia, 2019, Volume: 123, Issue:1 Topics: Adenosine Monophosphate; Aspirin; Brain; Female; Fibrinolytic Agents; Humans; Intracranial Aneurysm;	2019
Aggregometry Response to Half-dose Prasugrel in Flow-diverting Stent Implantation. Clinical neuroradiology, 2020, Volume: 30, Issue:3 Topics: Aspirin; Cerebral Angiography; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Ag	2020
Aspirin Monotherapy in Flow Diversion of Selected Internal Carotid Artery Aneurysms. World neurosurgery, 2020, Volume: 134 Topics: Angiography, Digital Subtraction; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebr	2020
Preliminary Experience with Cangrelor for Endovascular Treatment of Challenging Intracranial Aneurysms. Clinical neuroradiology, 2020, Volume: 30, Issue:3 Topics: Adenosine Monophosphate; Aneurysm, Ruptured; Aspirin; Cerebral Angiography; Embolization, Therapeuti	2020
[3-year follow-up after endovascular aneurysm treatment with Silk® flow diverter]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2013, Volume: 185, Issue:4 Topics: Adult; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Equipment Design	2013
SILK flow diverter for treatment of intracranial aneurysms: initial experience and cost analysis. Journal of neurointerventional surgery, 2013, Volume: 5 Suppl 3 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Angiography	2013
Imaging aspirin effect on macrophages in the wall of human cerebral aneurysms using ferumoxytol-enhanced MRI: preliminary results. Journal of neuroradiology = Journal de neuroradiologie, 2013, Volume: 40, Issue:3 Topics: Aged; Aneurysm, Ruptured; Aspirin; Female; Ferrosoferric Oxide; Fibrinolytic Agents; Humans; Intracr	2013
Aspirin--another type of headache it prevents. Journal of the American Heart Association, 2013, Mar-08, Volume: 2, Issue:2 Topics: Aneurysm, Ruptured; Aspirin; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Intracranial Aneur	2013
Using Leo Plus stent as flow diverter and endoluminal remodeling in endovascular treatment of intracranial fusiform aneurysms. Journal of neurointerventional surgery, 2013, Volume: 5 Suppl 3 Topics: Adult; Aged; Anesthesia, General; Aneurysm; Angiography, Digital Subtraction; Aspirin; Blepharoptosi	2013
Triple antiplatelet therapy with addition of cilostazol to aspirin and clopidogrel for Y-stent-assisted coil embolization of cerebral aneurysms. Acta neurochirurgica, 2013, Volume: 155, Issue:8 Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic;	2013
Progressive deconstruction: a novel aneurysm treatment using the pipeline embolization device for competitive flow diversion: case report. Neurosurgery, 2014, Volume: 10 Suppl 1 Topics: Adult; Arachnoid; Aspirin; Balloon Occlusion; Cerebral Angiography; Embolization, Therapeutic; Human	2014
Risk of hemorrhagic complication associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on dual antiplatelet therapy. Journal of neurosurgery, 2013, Volume: 119, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Humans; Hydrocephalus; Intracranial An	2013
Use of buddy wire to facilitate Y-configured stent placement in middle cerebral artery bifurcation aneurysms with daughter branches arising from the sac: a technical note. Neurosurgery, 2014, Volume: 10 Suppl 1 Topics: Angiography, Digital Subtraction; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeu	2014
Effect of antiplatelet therapy on thromboembolism after flow diversion with the pipeline embolization device. Journal of neurosurgery, 2013, Volume: 119, Issue:6 Topics: Adolescent; Adult; Aged; Anticoagulants; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Diffusion Ma	2013
Aspirin for prophylaxis against cerebral aneurysm rupture. World neurosurgery, 2014, Volume: 81, Issue:1 Topics: Aneurysm, Ruptured; Aspirin; Cyclooxygenase Inhibitors; Humans; Intracranial Aneurysm	2014
[Rescue treatment in acute thrombosis of intracranial stents]. Revista de neurologia, 2014, Feb-01, Volume: 58, Issue:3 Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Basilar Artery; Capillary Permeability; Cerebral Angiogr	2014
Treatment of blister-like aneurysms with the pipeline embolization device. Neurosurgery, 2014, Volume: 74, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty; Aspirin; Basilar Artery; Carotid Ar	2014
Use of thromboelastography to tailor dual-antiplatelet therapy in patients undergoing treatment of intracranial aneurysms with the Pipeline embolization device. Journal of neurointerventional surgery, 2015, Volume: 7, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combina	2015
Stent placement for complex middle cerebral artery aneurysms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:6 Topics: Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Angiography; Clopidogrel; Female;	2014
Delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysm: characteristics and optimal duration of preventative dual antiplatelet therapy. Radiology, 2014, Volume: 273, Issue:1 Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle	2014
Delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysm: characteristics and optimal duration of preventative dual antiplatelet therapy. Radiology, 2014, Volume: 273, Issue:1 Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle	2014
Delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysm: characteristics and optimal duration of preventative dual antiplatelet therapy. Radiology, 2014, Volume: 273, Issue:1 Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle	2014
Delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysm: characteristics and optimal duration of preventative dual antiplatelet therapy. Radiology, 2014, Volume: 273, Issue:1 Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle	2014
Treatment of ruptured intracranial aneurysms with the pipeline embolization device. Neurosurgery, 2015, Volume: 76, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Aspirin; Embolization, Therapeutic; Female; Foll	2015
Aspirin Inhibits Degenerative Changes of Aneurysmal Wall in a Rat Model. Neurochemical research, 2015, Volume: 40, Issue:7 Topics: Animals; Aspirin; Intracranial Aneurysm; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-	2015
Vessel Wall Magnetic Resonance Imaging, Inflammatory Cascade, Aspirin, and Aneurysm Rupture: Future Paradigms? World neurosurgery, 2015, Volume: 84, Issue:2 Topics: Aneurysm, Ruptured; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Inflammation Mediators	2015
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. Neurosurgery, 2015, Volume: 77, Issue:4 Topics: Aneurysm, Ruptured; Animals; Aspirin; Humans; Intracranial Aneurysm; Intramolecular Oxidoreductases;	2015
Ventriculostomy-Related Hemorrhage After Treatment of Acutely Ruptured Aneurysms: The Influence of Anticoagulation and Antiplatelet Treatment. World neurosurgery, 2015, Volume: 84, Issue:6 Topics: Acute Disease; Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopid	2015
In-Pipeline Stenosis: Incidence, Predictors, and Clinical Outcomes. Neurosurgery, 2015, Volume: 77, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Cerebral Angiography; Cohort Studies; Embolizat	2015
Computational fluid dynamics evaluation of flow reversal treatment of giant basilar tip aneurysm. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2015, Volume: 21, Issue:5 Topics: Aspirin; Basilar Artery; Blood Flow Velocity; Computer Simulation; Contraindications; Endovascular P	2015
Platelet reactivity and hemorrhage risk in neurointerventional procedures under dual antiplatelet therapy. Journal of neurointerventional surgery, 2016, Volume: 8, Issue:9 Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic;	2016
A New Protocol for Anticoagulation With Tirofiban During Flow Diversion. Neurosurgery, 2016, Volume: 78, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clinical Protocols; Clopidogrel; Embolizati	2016
Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:1 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Dia	2016
Insufficient platelet inhibition and thromboembolic complications in patients with intracranial aneurysms after stent placement. Journal of neurosurgery, 2016, Volume: 125, Issue:2 Topics: Adult; Aged; Aspirin; Clopidogrel; Drug Resistance; Female; Humans; Intracranial Aneurysm; Male; Mid	2016
[Stent-Assisted Coil Embolization of a Dissecting Aneurysm of the Posterior Cerebral Artery: A Case Report]. No shinkei geka. Neurological surgery, 2015, Volume: 43, Issue:12 Topics: Aortic Dissection; Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Fibrinolytic Agents; Hum	2015
Association between Postprocedural Infarction and Antiplatelet Drug Resistance after Coiling for Unruptured Intracranial Aneurysms. AJNR. American journal of neuroradiology, 2016, Volume: 37, Issue:6 Topics: Aged; Aspirin; Cerebral Infarction; Drug Resistance; Female; Humans; Intracranial Aneurysm; Magnetic	2016
The impact of aspirin and anticoagulant usage on outcomes after aneurysmal subarachnoid hemorrhage: a Nationwide Inpatient Sample analysis. Journal of neurosurgery, 2017, Volume: 126, Issue:2 Topics: Adolescent; Adult; Aged; Anticoagulants; Aspirin; Drug Administration Schedule; Female; Hospital Mor	2017
Endovascular Treatment of 147 Cases of Cavernous Carotid Aneurysms: A Single-Center Experience. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:8 Topics: Adult; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Stud	2016
Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. Hypertension (Dallas, Tex. : 1979), 2016, Volume: 68, Issue:2 Topics: Aneurysm, Ruptured; Animals; Aspirin; Cerebral Arteries; Cyclooxygenase 2; Cyclooxygenase Inhibitors	2016
Stent-assisted coiling in ruptured cerebral aneurysms: multi-center experience in acute phase. La Radiologia medica, 2017, Volume: 122, Issue:1 Topics: Acute Disease; Aneurysm, Ruptured; Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans;	2017
Contribution of whole platelet aggregometry to the endovascular management of unruptured aneurysms: an institutional experience. Journal of neurointerventional surgery, 2017, Volume: 9, Issue:10 Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Disease Management; Endovascular Procedures; Female; Hu	2017
Long-Term Follow-Up for a Giant Basilar Trunk Aneurysm Surgically Treated by Proximal Occlusion and External Carotid Artery to Posterior Cerebral Artery Bypass Using a Saphenous Vein Graft. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:11 Topics: Aspirin; Basilar Artery; Carotid Artery, External; Cerebral Angiography; Computed Tomography Angiogr	2016
Prasugrel versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2017, Volume: 23, Issue:1 Topics: Adult; Aged; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Embolizatio	2017
Thrombogenicity of flow diverters in an ex vivo shunt model: effect of phosphorylcholine surface modification. Journal of neurointerventional surgery, 2017, Volume: 9, Issue:10 Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Clopidogrel; Embolization, Therapeutic; Intracrania	2017
Antiplatelet therapy for the prevention of peri-coiling thromboembolism in high-risk patients with ruptured intracranial aneurysms. Journal of neurosurgery, 2017, Volume: 127, Issue:6 Topics: Adult; Aged; Aneurysm, Ruptured; Aspirin; Cerebral Angiography; Female; Humans; Intracranial Aneurys	2017
Management of a Patient Requiring Intrathecal Drain Insertion and Removal in the Setting of Concomitant Dual Antiplatelet Therapy With Clopidogrel and Aspirin: A Case Report. A & A case reports, 2017, Jun-01, Volume: 8, Issue:11 Topics: Aspirin; Catheters, Indwelling; Clopidogrel; Device Removal; Drainage; Drug Therapy, Combination; En	2017
Antiplatelet drug resistance did not increase the thromboembolic events after stent-assisted coiling of unruptured intracranial aneurysm: a single center experience of 99 cases. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017, Volume: 38, Issue:5 Topics: Adult; Aged; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Embolization, Therapeutic; Female; Human	2017
Going viral: fusiform vertebrobasilar and internal carotid aneurysms with varicella angiitis and common variable immunodeficiency. Journal of neurosurgery. Pediatrics, 2009, Volume: 4, Issue:6 Topics: Acyclovir; Adolescent; Aneurysm; Angiography, Digital Subtraction; Antiviral Agents; Aspirin; Basila	2009
[Tuberous sclerosis and intracranial aneurysms: a rare association]. Revue neurologique, 2010, Volume: 166, Issue:11 Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Carotid Artery Diseases; Humans; Intracranial Aneury	2010
Delayed intracranial hemorrhage associated with antiplatelet therapy in stent-assisted coil embolized cerebral aneurysms. Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 2 Topics: Adult; Aged; Aspirin; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Embolization, Therapeutic; F	2011
Endovascular treatment using predominantly stent-assisted coil embolization and antiplatelet and anticoagulation management of ruptured blood blister-like aneurysms. AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:4 Topics: Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Angiography; Clopidogrel; Combine	2011
Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. Archives of neurology, 2011, Volume: 68, Issue:3 Topics: Aged; Angiography; Antihypertensive Agents; Aorta; Aspirin; Circle of Willis; Connective Tissue Dise	2011
Dissection of the posterior inferior cerebellar artery in the hypereosinophilic syndrome. Journal of neurology, 2011, Volume: 258, Issue:12 Topics: Adolescent; Anti-Inflammatory Agents; Aortic Dissection; Arteries; Aspirin; Cerebellum; Female; Huma	2011
Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture. Stroke, 2011, Volume: 42, Issue:11 Topics: Aneurysm, Ruptured; Aspirin; Female; Humans; Intracranial Aneurysm; Male	2011
Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture. Stroke, 2011, Volume: 42, Issue:11 Topics: Aged; Aneurysm, Ruptured; Aspirin; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies;	2011
Small unruptured partially thrombosed aneurysms and stroke: report of three cases and review of the literature. Journal of neurointerventional surgery, 2012, Volume: 4, Issue:3 Topics: Aspirin; Atorvastatin; Craniotomy; Echocardiography, Transesophageal; Fibrinolytic Agents; Heptanoic	2012
Stent assisted coiling of the ruptured wide necked intracranial aneurysm. Journal of neurointerventional surgery, 2012, Volume: 4, Issue:4 Topics: Adult; Aneurysm, Ruptured; Aspirin; Clopidogrel; Cohort Studies; Embolization, Therapeutic; Female;	2012
Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting. Journal of neurointerventional surgery, 2011, Volume: 3, Issue:2 Topics: Aspirin; Body Mass Index; Body Weight; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel; Fem	2011
Predictors of hemorrhage volume and disability after perimesencephalic subarachnoid hemorrhage. Neurology, 2012, Mar-13, Volume: 78, Issue:11 Topics: Adult; Aged; Aspirin; Cerebral Angiography; Cerebral Veins; Cerebrovascular Circulation; Cohort Stud	2012
[Resistance to antiplatelet agents assessed by a point-of-care platelet function test and thromboembolic adverse events in neurointervention]. No shinkei geka. Neurological surgery, 2012, Volume: 40, Issue:5 Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Resistance; Female; Humans; Intracranial Aneurys	2012
Utility of VasoCT in the treatment of intracranial aneurysm with flow-diverter stents. Journal of neurosurgery, 2012, Volume: 117, Issue:1 Topics: Adult; Aged; Angiography, Digital Subtraction; Angioplasty, Balloon; Aspirin; Catheterization; Cereb	2012
Perioperative management of a neurosurgical patient requiring antiplatelet therapy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012, Volume: 19, Issue:9 Topics: Aged; Aspirin; Cerebral Angiography; Clopidogrel; Humans; Intracranial Aneurysm; Intracranial Thromb	2012
Early postmarket results after treatment of intracranial aneurysms with the pipeline embolization device: a U.S. multicenter experience. Neurosurgery, 2012, Volume: 71, Issue:6 Topics: Aged; Aspirin; Blood Vessel Prosthesis; Embolization, Therapeutic; Female; Fibrinolytic Agents; Foll	2012
Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques. Journal of neurosurgery, 2012, Volume: 117, Issue:5 Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Drug Therapy, Combina	2012
Reversible shortness of breath caused by the antiplatelet agent, clopidogrel. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Aspirin; Cilostazol; Clopidogrel; Dyspnea; Embolization, Therapeutic; Endovascular Procedures; Human	2013
Treatment of a pediatric recurrent fusiform middle cerebral artery (MCA) aneurysm with a flow diverter. BMJ case reports, 2012, Nov-15, Volume: 2012 Topics: Adolescent; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Humans; Intracran	2012
The effect of Neuroform stent-assisted coil embolization of wide-necked intracranial aneurysms and clinical factors on progressive aneurysm occlusion on angiographic follow-up. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:2 Topics: Adult; Aspirin; Cerebral Angiography; Clopidogrel; Disease Progression; Embolization, Therapeutic; F	2013
Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment. Neurosurgery, 2013, Volume: 72, Issue:3 Topics: Angioplasty; Aspirin; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Constriction, Patholog	2013
Basilar artery to bilateral posterior cerebral artery 'Y stenting' for endovascular reconstruction of wide-necked basilar apex aneurysms: report of three cases. Neurological research, 2004, Volume: 26, Issue:3 Topics: Adult; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Female; Follow-Up Studies; Humans; Intracra	2004
Progressive cervicocranial arteriopathy with dilatations and stenoses: case report. Arquivos de neuro-psiquiatria, 2004, Volume: 62, Issue:3B Topics: Adult; Arterial Occlusive Diseases; Aspirin; Basilar Artery; Carotid Artery Diseases; Carotid Artery	2004
[Stenting plus coiling: dangerous or helpful?]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2005, Volume: 177, Issue:9 Topics: Acute Disease; Aneurysm, Ruptured; Angiography, Digital Subtraction; Aspirin; Calcium Channel Blocke	2005
Anticoagulation regimes and their influence on the occlusion rate of aneurysms: an experimental study in rabbits. Neurosurgery, 2005, Volume: 57, Issue:5 Topics: Animals; Anticoagulants; Aspirin; Carotid Arteries; Disease Models, Animal; Embolization, Therapeuti	2005
Intravenous administration of acetylsalicylic acid during endovascular treatment of cerebral aneurysms reduces the rate of thromboembolic events. Stroke, 2006, Volume: 37, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Drug Evaluation; Embolization, Therape	2006
A new self-expandable nitinol stent for the treatment of wide-neck aneurysms: initial clinical experience. AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:7 Topics: Adult; Aged; Alloys; Aneurysm, Ruptured; Aspirin; Cerebral Angiography; Clopidogrel; Combined Modali	2008
Aspirin and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Journal of neurosurgery, 1995, Volume: 82, Issue:6 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; Cerebral Infarction; Female	1995
Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids. Acta neurochirurgica, 1994, Volume: 129, Issue:3-4 Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Brain Damage, Chronic; Cerebral Ventricles; Dexamethasone; Di	1994
Regression of a conservatively treated gigantic fusiform aneurysm of the middle cerebral artery. European neurology, 1997, Volume: 37, Issue:4 Topics: Adult; Aneurysm, Infected; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspiri	1997
Local intraarterial fibrinolysis of thromboemboli occurring during endovascular treatment of intracerebral aneurysm: a comparison of anatomic results and clinical outcome. AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:1 Topics: Adult; Aged; Aspirin; Cerebral Angiography; Embolization, Therapeutic; Female; Humans; Intracranial	1998
Detection of microemboli distal to cerebral aneurysms before and after therapeutic embolization. AJNR. American journal of neuroradiology, 1998, Volume: 19, Issue:7 Topics: Aneurysm; Anticoagulants; Aspirin; Basilar Artery; Brain Ischemia; Carotid Artery Diseases; Carotid	1998
Report of dissection of the internal carotid artery in three cases. Neurosurgical review, 1992, Volume: 15, Issue:1 Topics: Angiography, Digital Subtraction; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Arter	1992

aspirin and Intracranial Aneurysm