aspirin has been researched along with Intestinal Perforation in 15 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Intestinal Perforation: Opening or penetration through the wall of the INTESTINES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Little is known about the efficacy of proton pump inhibitors compared with H(2) receptor antagonists in preventing adverse upper gastrointestinal complications in patients with acute coronary syndrome (ACS) or ST elevation myocardial infarction (STEMI) receiving aspirin, clopidogrel, and enoxaparin or thrombolytics." | 9.16 | Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction. ( Chan, K; Chu, WM; Keung, KK; Kng, C; Kwan, A; Lam, KF; Lau, YK; Li, A; Ng, FH; Tunggal, P; Wong, BC, 2012) |
| "Current studies lack appropriate data on aspirin and other risk factors for gastrointestinal perforation." | 7.69 | Evidence of aspirin use in both upper and lower gastrointestinal perforation. ( Bajador, E; Benito, R; Esteva, F; Lanas, A; Sáinz, R; Serrano, P, 1997) |
| "Little is known about the efficacy of proton pump inhibitors compared with H(2) receptor antagonists in preventing adverse upper gastrointestinal complications in patients with acute coronary syndrome (ACS) or ST elevation myocardial infarction (STEMI) receiving aspirin, clopidogrel, and enoxaparin or thrombolytics." | 5.16 | Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction. ( Chan, K; Chu, WM; Keung, KK; Kng, C; Kwan, A; Lam, KF; Lau, YK; Li, A; Ng, FH; Tunggal, P; Wong, BC, 2012) |
| " Antecedents of mNEC included mother's identification as Black, consumption of aspirin during the pregnancy, and vaginal bleeding after the 12th week of gestation." | 3.83 | The antecedents and correlates of necrotizing enterocolitis and spontaneous intestinal perforation among infants born before the 28th week of gestation. ( Allred, EN; Grzybowski, M; Leviton, A; Martin, CR; Shah, B; Singh, R, 2016) |
| "Current studies lack appropriate data on aspirin and other risk factors for gastrointestinal perforation." | 3.69 | Evidence of aspirin use in both upper and lower gastrointestinal perforation. ( Bajador, E; Benito, R; Esteva, F; Lanas, A; Sáinz, R; Serrano, P, 1997) |
| "Randomized patients with available aspirin dosing information in COGENT (N = 3,752) were divided into "low-dose" (≤ 100 mg) and "high-dose" (>100 mg) aspirin groups." | 2.82 | Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Hsieh, WH; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; Schnitzer, TJ; Shook, TL; Vaduganathan, M, 2016) |
| "Few large studies have evaluated the adverse events associated with therapeutic colonoscopy for colorectal neoplasia, including bleeding and bowel perforation." | 1.43 | Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan. ( Fushimi, K; Hirata, Y; Koike, K; Matsui, H; Niikura, R; Yamada, A; Yasunaga, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Matsubara, S | 1 |
| Sada, KE | 1 |
| Sawada, H | 1 |
| Oida, J | 1 |
| Tanaka, K | 1 |
| García-Romera, Á | 1 |
| Soto-Darias, I | 1 |
| González-Hernández, S | 1 |
| González-Delgado, C | 1 |
| Bravo-Gutiérrez, A | 1 |
| Vaduganathan, M | 1 |
| Bhatt, DL | 1 |
| Cryer, BL | 1 |
| Liu, Y | 1 |
| Hsieh, WH | 1 |
| Doros, G | 1 |
| Cohen, M | 1 |
| Lanas, A | 3 |
| Schnitzer, TJ | 1 |
| Shook, TL | 1 |
| Lapuerta, P | 1 |
| Goldsmith, MA | 1 |
| Laine, L | 1 |
| Cannon, CP | 1 |
| Niikura, R | 1 |
| Yasunaga, H | 1 |
| Yamada, A | 1 |
| Matsui, H | 1 |
| Fushimi, K | 1 |
| Hirata, Y | 1 |
| Koike, K | 1 |
| Singh, R | 1 |
| Shah, B | 1 |
| Allred, EN | 1 |
| Grzybowski, M | 1 |
| Martin, CR | 1 |
| Leviton, A | 1 |
| Ge, FJ | 1 |
| Xu, JM | 1 |
| García-Rodríguez, LA | 1 |
| Polo-Tomás, M | 1 |
| Ponce, M | 1 |
| Quintero, E | 1 |
| Perez-Aisa, MA | 1 |
| Gisbert, JP | 1 |
| Bujanda, L | 1 |
| Castro, M | 1 |
| Muñoz, M | 1 |
| Del-Pino, MD | 1 |
| Garcia, S | 1 |
| Calvet, X | 1 |
| Ng, FH | 1 |
| Tunggal, P | 1 |
| Chu, WM | 1 |
| Lam, KF | 1 |
| Li, A | 1 |
| Chan, K | 1 |
| Lau, YK | 1 |
| Kng, C | 1 |
| Keung, KK | 1 |
| Kwan, A | 1 |
| Wong, BC | 1 |
| Robinson, MH | 1 |
| Wheatley, T | 1 |
| Leach, IH | 1 |
| Saldanha, R | 1 |
| Srikrishna, SV | 1 |
| John, AK | 1 |
| Serrano, P | 1 |
| Bajador, E | 1 |
| Esteva, F | 1 |
| Benito, R | 1 |
| Sáinz, R | 1 |
| Crowther, SM | 1 |
| Matthews, JG | 1 |
| Salawu, L | 1 |
| Olaomi, OO | 1 |
| Paul-Odo, B | 1 |
| Olayinka, OS | 1 |
| Durosinmi, MA | 1 |
| Hay, JM | 1 |
| Testart, J | 1 |
| Brodie, DA | 1 |
| Cook, PG | 1 |
| Bauer, BJ | 1 |
| Dagle, GE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease[NCT00557921] | Phase 3 | 5,000 participants (Anticipated) | Interventional | 2007-12-31 | Terminated (stopped due to Terminated by Sponsor) | ||
| Famotidine Compared With Esomeprazole in the Prevention of Ulcer Complications in Patients With Acute Coronary Syndrome or Myocardial Infarction[NCT00683111] | Phase 4 | 500 participants (Anticipated) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for aspirin and Intestinal Perforation
| Article | Year |
|---|---|
[Generation mechanisms and management strategies of adverse reactions to Bevacizumab during cancer treatment].
Topics: Angiogenesis Inhibitors; Angiotensin-Converting Enzyme Inhibitors; Antibodies, Monoclonal; Antibodie | 2010 |
Nonsteroidal antiinflammatory drug-induced colonic stricture. An unusual cause of large bowel obstruction and perforation.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Colonic Diseases; Delayed-Ac | 1995 |
2 trials available for aspirin and Intestinal Perforation
| Article | Year |
|---|---|
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy.
Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia; | 2016 |
Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction.
Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Chi-Square Distribution; Clopidogrel; Dou | 2012 |
11 other studies available for aspirin and Intestinal Perforation
| Article | Year |
|---|---|
Small Intestinal Perforation Caused by Enteric-coated Low-dose Aspirin.
Topics: Abdominal Pain; Aged; Aspirin; Humans; Intestinal Perforation; Male; Proton Pump Inhibitors | 2023 |
Small bowel obstruction secondary to enteroenteric fistula: An uncommon complication in chronic NSAID users.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Female; Huma | 2020 |
Factors predicting adverse events associated with therapeutic colonoscopy for colorectal neoplasia: a retrospective nationwide study in Japan.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Ce | 2016 |
The antecedents and correlates of necrotizing enterocolitis and spontaneous intestinal perforation among infants born before the 28th week of gestation.
Topics: Adult; Aspirin; Birth Weight; Enterocolitis, Necrotizing; Female; Gestational Age; Humans; Infant, N | 2016 |
The changing face of hospitalisation due to gastrointestinal bleeding and perforation.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Gastrointestinal | 2011 |
Acute duodenal perforation after coronary artery bypass grafting.
Topics: Acute Disease; Aspirin; Coronary Artery Bypass; Duodenal Diseases; Humans; Intestinal Perforation; M | 1994 |
Evidence of aspirin use in both upper and lower gastrointestinal perforation.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Helicobacter Infections; Helicobacte | 1997 |
Aspirin-related small bowel diaphragm disease identified during emergency laparotomy.
Topics: Aged; Aspirin; Emergencies; Humans; Intestinal Perforation; Jejunal Diseases; Laparotomy; Male | 2000 |
Aspirin-induced duodenal perforation in a Nigerian with sickle cell disease: a case report.
Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Hum | 2001 |
[Periarteritis nodosa and colonic perforation].
Topics: Aged; Amputation, Surgical; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Autopsy; Colon | 1974 |
Indomethacin-induced intestinal lesions in the rat.
Topics: Administration, Oral; Animals; Antacids; Aspirin; Atropine; Bile Ducts; Bretylium Compounds; Chlorpr | 1970 |