aspirin has been researched along with Intestinal Neoplasms in 13 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Intestinal Neoplasms: Tumors or cancer of the INTESTINES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nonsteroidal anti-inflammatory drug aspirin and the spice curcumin retard adenoma formation when administered long-term to Apc(Min/+) mice, a model of human familial adenomatous polyposis coli." | 3.72 | Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin. ( Clarke, AR; Gescher, A; Perkins, S; Steward, W, 2003) |
| "The Apc1638N mouse model, which carries a targeted mutant allele within the adenomatous polyposis (Apc) gene and develops intestinal tumours spontaneously, predominantly in the small bowel, was used to investigate the effects of two potential chemopreventive agents, aspirin and alpha-amylase resistant starch (RS)." | 3.70 | Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. ( Burn, J; Coaker, J; Fodde, R; Kartheuser, A; Kooshkghazi, MD; Mathers, JC; Williamson, SL, 1999) |
| " An initial dosing study performed in healthy mice indicates that aspirin at a dose of 25 mg/kg/d has a similar pharmacodynamic effect as low-dose aspirin treatment in human subjects (100 mg/d)." | 1.56 | Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. ( Hartung, NM; Kühl, AA; McDonald, FM; Ostermann, AI; Rohwer, N; Schebb, NH; Weylandt, KH; Zopf, D, 2020) |
| "Aspirin (400 ppm) has a similar impact on reducing prostaglandin levels, but in contrast to indomethacin, is uneffective in reducing the tumor load." | 1.31 | Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice. ( Chiu, CH; McEntee, MF; Whelan, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Rohwer, N | 1 |
| Kühl, AA | 1 |
| Ostermann, AI | 1 |
| Hartung, NM | 1 |
| Schebb, NH | 1 |
| Zopf, D | 1 |
| McDonald, FM | 1 |
| Weylandt, KH | 1 |
| Vieth, M | 1 |
| Görgens, D | 1 |
| Langner, C | 1 |
| Perkins, S | 1 |
| Clarke, AR | 2 |
| Steward, W | 1 |
| Gescher, A | 1 |
| Baenkler, HW | 1 |
| Eisen, GM | 1 |
| Sandler, RS | 1 |
| Wurzelmann, JI | 1 |
| Ransohoff, DF | 1 |
| Talal, A | 1 |
| Barnes, CJ | 1 |
| Lee, M | 1 |
| Williamson, SL | 1 |
| Kartheuser, A | 1 |
| Coaker, J | 1 |
| Kooshkghazi, MD | 1 |
| Fodde, R | 1 |
| Burn, J | 1 |
| Mathers, JC | 1 |
| Whelan, J | 2 |
| Chiu, CH | 2 |
| McEntee, MF | 2 |
| Williams, C | 1 |
| Shattuck-Brandt, RL | 1 |
| DuBois, RN | 1 |
| Sansom, OJ | 1 |
| Stark, LA | 1 |
| Dunlop, MG | 1 |
| Welch, CE | 1 |
| Hedberg, S | 1 |
| Stafford, ES | 1 |
| Zuidema, GD | 1 |
| Cameron, JL | 1 |
2 reviews available for aspirin and Intestinal Neoplasms
| Article | Year |
|---|---|
The role of COX-2 in intestinal cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 1999 |
Gastrointestinal hemorrhage. I. General considerations of diagnosis and the rapy.
Topics: Anus Diseases; Aspirin; Biliary Tract Diseases; Blood Coagulation Disorders; Burns; Child; Child, Pr | 1973 |
11 other studies available for aspirin and Intestinal Neoplasms
| Article | Year |
|---|---|
Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Azoxymethane; Carcinogens; Cel | 2020 |
[Pseudoneoplastic regeneration of the stomach. Histopathology and differential diagnosis].
Topics: Aspirin; Carcinoma; Diagnosis, Differential; Gastritis; Helicobacter Infections; Humans; Intestinal | 2010 |
Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin.
Topics: Adenoma; Administration, Oral; Aging; Animals; Anticarcinogenic Agents; Aspirin; Curcumin; Female; G | 2003 |
Functional-eicosanoid-test (FET) and disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Drug Hypersensitivity; Eicos | 2006 |
Evaluating risk: a primer for gastroenterologists.
Topics: Adenomatous Polyposis Coli; Aspirin; Colorectal Neoplasms; Duodenal Neoplasms; Humans; Intestinal Ne | 1995 |
Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin.
Topics: Adenoma; Adenomatous Polyposis Coli; Animals; Aspirin; Diet; Dinoprostone; Dose-Response Relationshi | 1998 |
Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months.
Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli; Adipose Tissue; alpha-Amylases; Animals; Anti-I | 1999 |
Intestinal tumor load in the Min/+ mouse model is not correlated with eicosanoid biosynthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Dinoprostone; Eicosanoi | 1999 |
Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.
Topics: 6-Ketoprostaglandin F1 alpha; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Ste | 2000 |
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Pair Mismatch; Colorectal Neoplasms, | 2001 |
Unusual causes of occult bleeding from the gastrointestinal tract.
Topics: Adolescent; Adult; Aged; Anemia; Aspirin; Child; Diagnosis, Differential; Esophagitis, Peptic; Femal | 1970 |