aspirin has been researched along with Innate Inflammatory Response in 773 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV infection remain to be established; further aspirin reduces CVD risk in the general population through production of some of these anti-inflammatory lipid mediators, but they have not been studied in PWH." | 9.69 | Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention. ( Aberg, JA; Brown, TT; Dalli, J; Funderburg, N; Gupta, A; Hunt, PW; Kitch, D; Moisi, D; O'Brien, MP; Shivakoti, R; Tien, PC, 2023) |
| "5 mg twice daily rivaroxaban and aspirin in patients with polyvascular disease (coronary artery disease, peripheral arterial disease or both), the underlying mechanism of which is not clearly understood." | 9.34 | Synergistic influence of rivaroxaban on inflammation and coagulation biomarkers in patients with coronary artery disease and peripheral artery disease on aspirin therapy. ( Bafford, R; Cummings, C; Gonze, M; Gurbel, P; Mackrell, P; Rout, A; Sukhi, A; Tantry, U; Ulloa, K, 2020) |
| "Aspirin and statin use may lower the risk of advanced/fatal prostate cancer, possibly by reducing intraprostatic inflammation." | 9.34 | Use of Aspirin and Statins in Relation to Inflammation in Benign Prostate Tissue in the Placebo Arm of the Prostate Cancer Prevention Trial. ( Arnold, KB; Benedetti, I; De Marzo, AM; Drake, CG; Goodman, PJ; Gumuskaya, B; Hurwitz, LM; Isaacs, WB; Kulac, I; Liu, JO; Lucia, MS; Marrone, MT; Nelson, WG; Pan, F; Platz, EA; Tangen, CM; Thompson, IM; Valle, JABD, 2020) |
| "Our results provide preliminary evidence that short-term aspirin and pravastatin therapy reduces hsCRP and LDL cholesterol among overweight and obese women of reproductive age, including those with low-grade inflammation." | 9.30 | Pilot randomized trial of short-term changes in inflammation and lipid levels during and after aspirin and pravastatin therapy. ( Andriessen, VC; Connell, MT; Flannagan, KS; Hill, MJ; Mumford, SL; Perkins, NJ; Plowden, TC; Radoc, JG; Schisterman, EF; Sjaarda, LA; Zolton, JR, 2019) |
| "To test the hypothesis that aspirin reduces inflammation in clinically relevant human models that recapitulate pathophysiological mechanisms implicated in the development of ARDS." | 9.24 | Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. ( Fitzgerald, M; Hamid, U; Kissenpfennig, A; Krasnodembskaya, A; Lefrancais, E; Looney, MR; McAuley, DF; McNamee, J; O'Kane, CM; Scott, C; Scott, J; Shyamsundar, M; Simpson, AJ; Verghis, R, 2017) |
| " There are indications from experimental and observational studies that aspirin may reduce inflammation associated with infection." | 9.24 | AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. ( Eisen, DP; Leder, K; Lockery, J; McBryde, ES; McNeil, JJ; Moore, EM; Pilcher, D; Wolfe, R; Woods, RL, 2017) |
| "In a nested case-control study in the Physicians' Health Study, we prospectively investigated the associations of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor receptor 2 (TNFR-2) with risk of colorectal cancer, and whether aspirin modified these associations among 268 colorectal cancer patients and 446 age- and smoking-matched controls." | 9.22 | Inflammatory biomarkers, aspirin, and risk of colorectal cancer: Findings from the physicians' health study. ( Chan, AT; Kim, C; Ma, J; Rifai, N; Sesso, HD; Stampfer, MJ; Zhang, X, 2016) |
| "ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly." | 9.22 | ASPREE-D: Aspirin for the prevention of depression in the elderly. ( Berk, M; Fitzgerald, SM; Grimm, R; Kirpach, B; Lockery, JE; McNeil, JJ; Mohebbi, M; Murray, AM; Nelson, MR; Reid, CM; Shah, RC; Storey, E; Wolfe, R; Woods, RL, 2016) |
| "Although studies have reported direct inhibition of inflammatory pathways with niacin, the effect of niacin on arterial wall inflammation remains unknown." | 9.20 | A pilot trial to examine the effect of high-dose niacin on arterial wall inflammation using fluorodeoxyglucose positron emission tomography. ( Alavi, A; deGoma, EM; Dunbar, RL; Litt, HI; Mehta, NN; Mohler, ER; Pollan, L; Rader, DJ; Saboury, B; Salavati, A; Schoen, M; Shinohara, RT; Torigian, DA; Woo, J, 2015) |
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 9.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "Using five-colour flow cytometry the platelet surface expression of CD62P and CD40L and subpopulations of leukocyte-platelet aggregates were assessed in 63 acute stroke patients and 40 healthy volunteers at baseline and after a 10-day period of aspirin intake at a daily dose of 150 mg." | 9.15 | Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. ( Dworacki, G; Golanski, J; Kozubski, W; Kufel-Grabowska, J; Lukasik, M; Michalak, S; Watala, C, 2011) |
| "One hundred and twenty-one consecutive patients with metabolic syndrome were randomized into three groups, receiving 100 mg/day of aspirin, 300 mg/day of aspirin or a placebo, respectively, for 2 weeks." | 9.14 | Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome. ( Adhikari, CM; Gao, XR; Guo, XG; He, XY; Lin, J; Peng, LY; Zhai, YS; Zhang, LY; Zuo, ZY, 2009) |
| "Aspirin can cause bronchoconstriction in some asthmatic patients through increased production of proinflammatory mediators, particularly leukotrienes." | 9.13 | Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma. ( Hopkinson, P; Lipworth, BJ; Meldrum, KT; Menzies, D; Nair, A, 2008) |
| "Aspirin reduces several pro-inflammatory markers in patients with coronary heart disease (CHD), while limited data exists with clopidogrel." | 9.12 | No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease. ( Arnesen, H; Pettersen, AA; Seljeflot, I; Solheim, S, 2006) |
| "The aim of this study was to assess the influence of aspirin on selected inflammatory markers in patients recovering from acute myocardial infarction (AMI)." | 9.10 | Influence of aspirin on inflammatory markers in patients after acute myocardial infarction. ( Arnesen, H; Eikvar, L; Hurlen, M; Seljeflot, I; Solheim, S, 2003) |
| "Experimental inflammation produces endothelial dysfunction, which can be prevented by pretreatment with aspirin." | 9.10 | Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin. ( Allen, M; Hingorani, AD; Kharbanda, RK; Klein, N; MacAllister, RJ; Vallance, P; Walton, B, 2002) |
| "Although administration of cromolyn sodium is one of the most useful drugs for the treatment of aspirin-intolerant asthma (AIA), both its pharmacologic mechanism of action and association with the pathogenesis remain obscure." | 9.09 | Cromolyn sodium suppresses eosinophilic inflammation in patients with aspirin-intolerant asthma. ( Akahori, K; Amayasu, H; Hasegawa, H; Ishizaki, Y; Nakabayashi, M; Nakagawa, H; Shoji, T; Yoshida, S, 2001) |
| "The efficacy and safety of fenoprofen calcium (Nalfon, Dista, Indianapolis, IN) and aspirin for treating acute inflammatory soft tissue injuries were compared in a 3 to 10-day randomized, double-blind, parallel study of 100 patients with bruise (1), bursitis (33), ligamentous strain (8), myofascitis (43), and tendinitis (15)." | 9.05 | Fenoprofen calcium versus aspirin in the treatment of acute inflammatory soft-tissue injuries. ( McIlwain, HH, 1985) |
| "Dual pathway inhibition (DPI) with low-dose rivaroxaban and aspirin in patients with coronary artery disease (CAD) and/or peripheral artery disease (PAD) reduces the occurrence of cardiovascular (CV) events; however, the underlying mechanisms explaining these latter CV benefits are not clearly understood." | 8.31 | Dual Pathway Inhibition with Rivaroxaban and Aspirin Reduces Inflammatory Biomarkers in Atherosclerosis. ( Attena, E; Cotticelli, C; D'Alterio, G; D'Onofrio, A; Fabiani, D; Golino, P; Leonardi, S; Maione, B; Nigro, G; Rago, A; Russo, V; Sarpa, S, 2023) |
| "We isolated extracellular vesicles (EVs) from periodontal stem cells (PDLSCs) and loaded with aspirin by sonication, and then evaluated the treatment efficacy of aspirin-loaded vesicles (EVs-ASP) in periodontitis model in mice." | 8.31 | Aspirin loaded extracellular vesicles inhibit inflammation of macrophages via switching metabolic phenotype in periodontitis. ( Da, N; He, X; Li, B; Shi, Y; Wang, Y; Yang, J; Zhang, R, 2023) |
| "To investigate the effect of Aspirin Triggered-Resolvin D1 (AT-RvD1) as an anti-pyroptosis and anti-inflammatory agent on lipopolysaccharide (LPS) induced acute keratitis in Wistar rats." | 8.12 | The inhibiting effect of Aspirin Triggered-Resolvin D1 in non-canonical pyroptosis in rats with acute keratitis. ( Ke, B; Liu, M; Wang, P; Yuan, Y; Zhu, C, 2022) |
| " procera dried latex extract prepared in methanol (MeDL) against inflammation and oxidative stress in experimental model of colorectal carcinoma (CRC)." | 8.12 | Anti-inflammatory and antioxidant effect of methanol extract of latex of Calotropis procera in rat model of colorectal cancer. ( Das, P; Kumar, VL; Verma, S, 2022) |
| " Aspirin is known as a potent anti-inflammatory drug, but its role in adipogenesis, adipocyte-specific inflammation, and metabolic syndrome is not well characterized." | 8.12 | Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice. ( Ahmed, F; Amin, MT; Begum, R; Bhowmik, DR; Hossain, MS; Islam, MA; Roy, S, 2022) |
| "Aspirin inhibited carcinogenesis of intestinal mucosal cells in the ulcerative colitis model by inhibiting the interleukin-6/ Janus kinase/signal transducer and activator of transcription 3 signaling pathway and promoted apoptosis, thereby suppressing proliferation." | 8.12 | Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through Inhibiting IL-6/JAK/STAT3 Signaling Pathway and Modulating Apoptosis and Proliferation. ( Chen, Y; Diao, T; Li, D; Shang, G; Shi, L; Sun, L; Yin, X, 2022) |
| " Here, we report the case of an 82-year-old Japanese woman with normal renal function who developed multiple cerebral infarctions due to CAT that grew rapidly, associated with inflammation from an antecedent infection, and diminished rapidly by detachment of fibrin on the mass surface and antithrombotic drugs." | 8.12 | Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report. ( Doyu, M; Ito, H; Kimura, M; Matsuyama, K; Niwa, JI, 2022) |
| "To determine the impact of low-dose aspirin (81 mg) on markers of maternal inflammation and placental function." | 8.12 | The impact of low-dose aspirin on markers of inflammation and placental function: an ancillary study of the ASPIRIN trial. ( Araganji, R; Goudar, SS; Hoffman, MK; Kavi, A; Somannavar, MS; Vernekar, SS, 2022) |
| "Plasma from women with pre-eclampsia induced TBARS and nitrotyrosine production on endothelial and U937 cells." | 7.96 | Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia. ( Alvarez, AM; Cadavid J, AP; Gil-Villa, AM; Rojas-López, M; Velásquez-Berrío, M, 2020) |
| "Beside its therapeutic role in the thrombotic vascular events, Clopidogrel confers significant protection against ischemic myocardial injury by counteracting the platelet-mediated inflammation and oxidative stress associated with HFD-C consumption in animals." | 7.96 | Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice. ( Korish, AA, 2020) |
| "Influence of pre-existing treatment with aspirin and/or statins prior to a first acute coronary syndrome (ACS) on clinical presentation, infarct size and inflammation markers." | 7.91 | Pre-existing treatment with aspirin or statins influences clinical presentation, infarct size and inflammation in patients with de novo acute coronary syndromes. ( Denegri, A; Lüscher, TF; Mach, F; Matter, CM; Muller, O; Obeid, S; Räber, L; Shahin, M; Weidmann, L; Yousif, N, 2019) |
| "In the present study, we aimed to evaluate the role of aspirin-triggered resolvin D1 (AT-RvD1) in paraquat (PQ)-induced acute lung injury (ALI) in mice." | 7.91 | Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice. ( Hu, X; Shen, H; Wang, Y; Zhang, L; Zhao, M, 2019) |
| " We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of tumor infiltrating immune cells, and survival in colorectal cancer (CRC), and these relationships could be altered by aspirin use." | 7.91 | Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer. ( Herzig, KH; Karhu, T; Karttunen, TJ; Klintrup, K; Mäkelä, J; Mäkinen, MJ; Minkkinen, I; Sirniö, P; Tuomisto, A; Väyrynen, JP; Väyrynen, SA, 2019) |
| "After aspirin treatment, the inflammation and scar formation in injury tendon were significantly inhibited by aspirin." | 7.91 | Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway. ( Chen, W; He, G; Kang, X; Lyu, J; Mu, M; Shi, Y; Tang, H; Tang, K; Wang, Y; Yang, M; Zhang, J; Zhou, B; Zhou, M; Zhu, M, 2019) |
| "BackgroundHigh-dose aspirin (HDA) is used with intravenous immunoglobulin (IVIg) in Kawasaki disease (KD)." | 7.88 | Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease. ( Binstadt, BA; Braunlin, EA; Migally, K; Zhang, L, 2018) |
| "Clinical features of aspirin-exacerbated respiratory disease (AERD) are characterized by overproduction of cysteinyl leukotrienes (LT) and eosinophil activation, in which epithelial cells contribute to eosinophilic airway inflammation." | 7.88 | Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease. ( Choi, Y; Kim, HM; Kim, SH; Park, HS; Pham, DL; Trinh, HKT, 2018) |
| "01) decreased the paw oedema volume and granuloma dry weight as compared to control and it was comparable to that of aspirin and histopathological sections showed a decrease in granulation tissue formation as compared to control." | 7.88 | Effect of anti-inflammatory activity of ranolazine in rat model of inflammation. ( Davangeri, R; Hashilkar, NK; Majagi, SI; Naveena, R, 2018) |
| " Aspirin has many properties including anti-inflammation and anti-cancer." | 7.83 | Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma. ( Aukkanimart, R; Boonmars, T; Jiraporn, S; Loilome, W; Nadchanan, W; Namwat, N; Ruangjirachuporn, W; Sriraj, P; Sudsarn, P, 2016) |
| "We measured serum levels of proinflammatory/prothrombotic markers P-selectin, CD40L, matrix metalloproteinase 9 (MMP-9), intracellular adhesion molecule 1 (ICAM-1), and interleukin (IL)-6 in ischemic stroke patients, correlating their levels with the results of aspirin (ASA) and clopidogrel antiplatelet responses, using 3 "point of care" platelet function instruments, thromboelastograph (TEG), Accumetrics (ACU), and impedance aggregometer (IMP)." | 7.83 | Relationship between Inflammation and Aspirin and Clopidogrel Antiplatelet Responses in Acute Ischemic Stroke. ( Ambrus, JL; Chichelli, T; Ching, M; Janicke, D; Munschauer, F; Sawyer, R; Sternberg, D; Sternberg, Z; Yu, J, 2016) |
| "miR-145 is involved in the anti-proliferation and anti-inflammation effects of aspirin on VSMCs by inhibiting the expression of CD40." | 7.83 | miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40. ( Chen, M; Guo, R; Guo, X; Peng, X; Wu, T; Yu, L; Zhang, B, 2016) |
| "Aspirin has a clear anti-inflammatory effect and is used as an anti-inflammatory agent for both acute and long-term inflammation." | 7.83 | Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. ( Ding, Y; Gao, L; Li, W; Liu, G; Liu, J; Lu, G; Pan, Y; Tong, Z; Tu, J; Wang, Y, 2016) |
| " A growing body of evidence reveals that aspirin is a potent antioxidant and anti-inflammation drug." | 7.80 | Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis. ( Chen, JW; Cheng, YH; Chien, Y; Chiou, SH; Hsiao, CY; Huang, PH; Kao, CL; Leu, HB; Liao, YW; Lin, SJ; Tsai, KL; Wang, CY; Yang, YP, 2014) |
| "Investigate the therapeutic effect of regional arterial infusion (RAI) with Aspirin-Triggered Lipoxin A4 (ATL) in experimental severe acute pancreatitis (SAP) in rats." | 7.80 | Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis. ( Andersson, R; Chen, B; Jin, Y; Sun, H; Wang, W; Xie, J; Xie, Y; Xu, D; Yang, F; Zhou, M, 2014) |
| "Aspirin was first used for patients with Kawasaki disease(KD) at 1970s." | 7.80 | [Aspirin treatment for patients with Kawasaki disease]. ( Hamada, H, 2014) |
| "Tumor-associated inflammation is a driving force in several adult cancers and intake of low-dose aspirin has proven to reduce cancer incidence." | 7.79 | Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. ( Carlson, LM; Idborg, H; Jakobsson, PJ; Kogner, P; Rasmuson, A; Segerström, L; Sveinbjörnsson, B, 2013) |
| "Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC." | 7.77 | Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. ( Chen, H; Gao, W; Mao, X; Ren, C; Song, T; Tian, Y; Wang, D; Ye, Y, 2011) |
| "Although its role to prevent secondary cardiovascular complications has been well established, how acetyl salicylic acid (ASA, aspirin) regulates certain key molecules in the atherogenesis is still not known." | 7.76 | Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages. ( Gan, L; Jiang, Y; Li, L; Liu, H; Lu, L; Peng, J; Shen, L; Su, C; Zhang, L; Zhang, Q, 2010) |
| " Here, we have assessed the role played by NO, formed by inducible NOS (iNOS), in the inflammation induced by aspirin in the gut, by modulating HIF-1 activity." | 7.76 | Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1alpha in macrophages during aspirin-induced mesenteric inflammation. ( Barrachina, MD; Calatayud, S; Díez, I; Esplugues, JV; Hernández, C; O'Connor, JE; Quintana, E, 2010) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 7.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| "In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction." | 7.75 | The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009) |
| "The Aspirin/Folate Polyp Prevention Trial found that aspirin, but not folic acid, reduced recurrence of colorectal adenomas." | 7.75 | Antagonistic effects of aspirin and folic acid on inflammation markers and subsequent risk of recurrent colorectal adenomas. ( Ahnen, DJ; Baron, JA; Barry, EL; Bresalier, RS; Cushman, M; Ho, GY; McKeown-Eyssen, G; Rohan, TE; Saibil, F; Sandler, RS; Xue, X, 2009) |
| "The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception (levels I, II, and III) using the "Pain-induced functional impairment model in the rat"." | 7.74 | The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. ( Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Godínez-Chaparro, B; Guevara-López, U; Huerta-Cruz, JC; López-Muñoz, FJ, 2008) |
| "Effects of different doses of aspirin, compared to equimolar doses of nitric oxide (NO)-donating aspirin (NCX 4016), and of a single dose of paracetamol, compared to an equimolar dose of NO-donating paracetamol (NCX 701) were investigated in acute zymosan-induced air pouch inflammation in rats." | 7.74 | Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats. ( Mamuk, S; Melli, M, 2007) |
| "In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition." | 7.74 | Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. ( Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2008) |
| " The aims of the present study were: to verify the incidence of Normal Weight Obese (NWO) syndrome; to evaluate by PINI the effect of 8 weeks acetyl salicylic (100 mg/die) and atorvastatin (10 mg/die) combined treatment on chronic inflammation in 52 selected HD patients." | 7.74 | Anti-inflammatory effects of combined treatment with acetyl salicylic acid and atorvastatin in haemodialysis patients affected by Normal Weight Obese syndrome. ( De Angelis, S; De Lorenzo, A; Di Daniele, N; Di Renzo, L; Miani, N; Noce, A; Tozzo, C, 2008) |
| "To address the hypothesis that expression of 1 or more EP receptors on nasal mucosal inflammatory cells is deficient in patients with aspirin-sensitive compared with nonaspirin-sensitive polypoid rhinosinusitis." | 7.73 | Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells. ( Corrigan, CJ; Lee, TH; Meng, Q; Parikh, A; Scadding, G; Ying, S, 2006) |
| "Several studies have suggested the involvement of an autoimmune mechanism in aspirin (ASA)-intolerant asthma." | 7.73 | Circulating autoantibodies in patients with aspirin-intolerant asthma: an epiphenomenon related to airway inflammation. ( Choi, JH; Kim, SH; Nahm, DH; Park, HS; Suh, CH; Ye, YM, 2006) |
| " It is here reported that LXA(4), LXB(4), the aspirin-triggered LX (ATL) epimer, 15-epi-LXB(4), and a stable synthetic analogue 15(R/S)-methyl-LXA(4) stimulate phagocytosis of exogenously administered excess apoptotic PMN by macrophages (M phi) in vivo in a classic model of acute inflammation, namely thioglycollate-induced peritonitis." | 7.71 | Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. ( Berlasconi, G; Brady, HR; Cottell, D; Erwig, L; Godson, C; Harvey, K; Mitchell, S; Petasis, NA; Rees, AJ; Reville, K; Savill, J; Thomas, G, 2002) |
| "In men with hypercholesterolemia simvastatin treatment lowers serum levels of CRP and proinflammatory cytokines." | 7.71 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia. ( Gajewski, P; Jankowski, M; Musial, J; Sydor, W; Szczeklik, A; Undas, A, 2001) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 7.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The inflammatory cell infiltrate in bronchial biopsies of 12 aspirin-sensitive asthmatic (ASA) subjects and eight non-aspirin-sensitive (non-ASA) control subjects have been compared." | 7.69 | Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. ( Barker, J; Christie, PE; Lee, TH; Nasser, SM; Pfister, R; Schmitz-Schumann, M; Sousa, AR, 1996) |
| "This study, performed in freely moving rats, evaluates the effects of the two most prescribed analgesics, aspirin and acetaminophen, on carrageenin inflammation and the associated c-Fos expression in the rat lumbar spinal cord." | 7.69 | Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation. ( Besson, JM; Buritova, J; Honoré, P, 1995) |
| "Serum salicylate concentrations were measured in 60 patients with acute phase Kawasaki disease (KD), who were treated with intravenous aspirin (IVASP), to evaluate its anti-inflammatory effect in the treatment of KD." | 7.68 | Treatment of Kawasaki disease using the intravenous aspirin anti-inflammatory effect of salicylate. ( Matsuo, N; Saji, T; Umezawa, T, 1992) |
| "The effect of combination NSAID therapy of tilomisole with aspirin or naproxen was studied in rats with carrageenan-induced paw edema and established adjuvant arthritis." | 7.68 | Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat. ( Calhoun, W; Carlson, RP; Copenhaver, TW; Datko, LJ; Gilman, SC, 1992) |
| "A mode of interaction of bradykinin with prostaglandins (PGs) in pain were compared with that in acute inflammation." | 7.67 | Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation. ( Harada, Y; Hori, Y; Katori, M; Tanaka, K; Uchida, Y, 1986) |
| " Aspirin also reduced the levels of PGE2 and TXB2 in the exudate but did not consistently affect PMN influx, thereby confirming that inhibition of cyclo-oxygenase does not reduce cell migration in inflammation." | 7.66 | The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. ( Moncada, S; Salmon, JA; Simmons, PM, 1983) |
| "Inflammation is linked to causes of infertility." | 6.84 | Preconception Low-Dose Aspirin Restores Diminished Pregnancy and Live Birth Rates in Women With Low-Grade Inflammation: A Secondary Analysis of a Randomized Trial. ( Galai, N; Mitchell, E; Mumford, SL; Perkins, NJ; Radin, RG; Schisterman, EF; Silver, RM; Sjaarda, LA; Stanford, JB; Wactawski-Wende, J; Wilcox, B, 2017) |
| "Inflammation has been linked to several complications in pregnancy, including pregnancy loss." | 6.61 | The role of aspirin and inflammation on reproduction: the EAGeR trial ( Holland, TL; Kim, K; Levine, LD; Mumford, SL; Schisterman, EF; Sjaarda, LA, 2019) |
| "Aspirin also plays a role by its anti-inflammatory action and the stimulation of antitumor immunity." | 6.58 | [Aspirin and colorectal cancer]. ( Di Fiore, F; Grancher, A; Michel, P; Sefrioui, D, 2018) |
| "Metformin and aspirin have been explored as two emerging cancer chemoprevention agents for different types of cancers, including pancreatic cancer." | 6.50 | Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. ( DiPaola, RS; Tan, XL; Yang, CS; Yue, W, 2014) |
| "Aspirin and statins have been integral in the prevention of atherosclerotic disease." | 6.48 | Do aspirin and statins prevent severe sepsis? ( O'Neal, HR; Sanchez, MA; Thomas, CB, 2012) |
| " This study evaluated the safety and efficacy of treatment with glycoprotein IIb/IIIa inhibition in addition to aspirin, low molecular-weight heparin and its influence on coagulation and inflammation." | 6.21 | Coagulation, inflammation and myocardial dysfunction in unstable coronary artery disease and the influence of glycoprotein IIb/IIIa inhibition and low molecular weight heparin. ( James, S, 2004) |
| "Systematic inflammation has been reported to contribute to cancer progression through various mechanisms; however, the exact mechanism is still the subject of research." | 5.91 | Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration. ( Fukuda, K; Hirahashi, J; Kawakubo, H; Kitagawa, Y; Kobayashi, R; Matsuda, S; Matsui, K; Nakamura, R; Nishimura, E; Okubo, K; Takeuchi, M, 2023) |
| "Type 1 diabetes mellitus was established by intraperitoneal injection of streptozotocin (65 mg/kg)." | 5.91 | Long-term aspirin administration suppresses inflammation in diabetic cystopathy. ( Du, H; Li, N; Liu, J; Qin, Y; Xu, F; Xu, Y; Zhang, J, 2023) |
| " The collection days (CD) were the second and seventh days after stable aspirin dosing and then a convalescent time point 2-9 months later." | 5.72 | Urinary 11-dehydrothromboxane B2 aspirin efficacy testing is sensitive to perioperative inflammation in pediatric solid-organ transplant patients. ( Boucher, AA; Francisco, BJ; Luchtman-Jones, L; Martin, J; Martin, M; Nathan, JD; Pfeiffer, A; Shova, A; Tiao, GM, 2022) |
| "Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery." | 5.72 | Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022) |
| " Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV infection remain to be established; further aspirin reduces CVD risk in the general population through production of some of these anti-inflammatory lipid mediators, but they have not been studied in PWH." | 5.69 | Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention. ( Aberg, JA; Brown, TT; Dalli, J; Funderburg, N; Gupta, A; Hunt, PW; Kitch, D; Moisi, D; O'Brien, MP; Shivakoti, R; Tien, PC, 2023) |
| "Aspirin and atorvastatin could play a role in targeting HIV-associated inflammation." | 5.69 | An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV. ( Baker, JV; Gorelick, RJ; Krishnan, S; Laidlaw, E; Lisco, A; Manion, M; Migueles, SA; Mystakelis, HA; Poole, A; Rupert, A; Sereti, I; Welker, JL; Wilson, E, 2023) |
| "Aspirin is known to cause mucosal injury leading to increased gut permeability and tight junction damage and can be used as a model to study leaky gut in cattle." | 5.62 | Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle. ( Briggs, NG; Godoi, LA; Schoonmaker, JP; Silva, BC, 2021) |
| " Here, we confirmed the protective effect and mechanism of XST combined with DAPT (XST+ASA+CLP) on cerebral ischemia/reperfusion injury, exploring their better pharmacological action for clinical patients." | 5.62 | Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway. ( Dong, DX; Meng, XB; Qu, MW; Sun, GB; Sun, XB; Zhao, LY; Zhu, T, 2021) |
| " On-demand, local delivery of anti-inflammatory drugs to target tissues provides an approach for more effective drug dosing while reducing the adverse effects of systemic drug delivery." | 5.56 | Adaptive in vivo device for theranostics of inflammation: Real-time monitoring of interferon-γ and aspirin. ( Cao, C; Chen, X; Jin, R; Liu, G; Liu, GJ; Liu, Z; Ni, S; Wei, H; Young, HA, 2020) |
| "Aspirin treatment modified metabolites involved in suppressing lipogenesis, oxidative stress, and neoplastic formation." | 5.56 | Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth. ( Chiu, HH; Hsieh, CC; Kuo, CH; Wang, CH, 2020) |
| "The widely recognized anti-cancer potential of aspirin has created a broad interest to explore the clinical benefits of aspirin in cancer therapy." | 5.56 | Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner. ( Du, R; Luo, N; Shen, W; Xiang, R; Zhang, X, 2020) |
| "Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa." | 5.51 | Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. ( Abd El-Ghffar, EA; Mahmoud, YI, 2019) |
| "Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease." | 5.48 | Melatonin: A hypothesis for Kawasaki disease treatment. ( Gil-Martín, E; López-Muñoz, F; Patiño, P; Ramos, E; Reiter, RJ; Romero, A, 2018) |
| "Aspirin is a very common anti-inflammatory medication to relieve aches and pains." | 5.43 | Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation. ( Bu, W; Chang, B; Gu, Z; Li, C; Lin, C; Shen, Y; Sun, H; Xu, X; Yang, B; Zhang, K; Zhao, L; Zheng, C, 2016) |
| "CAPE-indomethacin hybrid was able to significantly attenuate the clinical grading and the PGE2 aqueous levels only at the highest dose (0." | 5.42 | Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation. ( Bucolo, C; Drago, F; Modica, MN; Pittalà, V; Romano, GL; Romeo, G; Salerno, L; Salomone, S; Siracusa, MA, 2015) |
| " We were unable to draw any conclusions regarding acute coronary syndromes, mortality, or length of hospital stay, or for the comparison IVIG versus prednisolone." | 5.41 | Intravenous immunoglobulin for the treatment of Kawasaki disease. ( Broderick, C; Ito, S; Kobayashi, S; Kobayashi, T; Suto, M, 2023) |
| "Chronic inflammation may lead to frailty, however the potential for anti-inflammatory medications such as aspirin to prevent frailty is unknown." | 5.41 | Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians' Health Study. ( Djousse, L; Driver, JA; Dufour, AB; Gaziano, JM; Orkaby, AR; Sesso, HD; Travison, TG; Yang, L, 2021) |
| "Choline was described to potentiate the antinociceptive action of aspirin at small doses in several inflammatory pain models." | 5.40 | Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide. ( Pan, ZY; Wang, H, 2014) |
| "Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms." | 5.40 | Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014) |
| "Inflammation has been proposed to modify platelet function." | 5.39 | Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. ( Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB, 2013) |
| "Aspirin has a beneficial role in prevention of cardiovascular and thromboembolic events." | 5.38 | High frequency of aspirin resistance in patients with nephrotic syndrome. ( Agbaht, K; Akoglu, H; Dede, F; Falay, MY; Odabas, AR; Ozet, G; Piskinpasa, S, 2012) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 5.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "Aspirin has anti-inflammatory and antineoplastic activity." | 5.35 | Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils. ( Chan, AO; Chen, MH; Cho, CH; Gu, Q; Hu, PJ; Li, GQ; Liang, YJ; Lin, HL; Qiao, L; So, WH; Tatematsu, M; Tsukamoto, T; Wong, BC; Xia, HH; Yuen, MF, 2008) |
| "5 mg twice daily rivaroxaban and aspirin in patients with polyvascular disease (coronary artery disease, peripheral arterial disease or both), the underlying mechanism of which is not clearly understood." | 5.34 | Synergistic influence of rivaroxaban on inflammation and coagulation biomarkers in patients with coronary artery disease and peripheral artery disease on aspirin therapy. ( Bafford, R; Cummings, C; Gonze, M; Gurbel, P; Mackrell, P; Rout, A; Sukhi, A; Tantry, U; Ulloa, K, 2020) |
| "Aspirin and statin use may lower the risk of advanced/fatal prostate cancer, possibly by reducing intraprostatic inflammation." | 5.34 | Use of Aspirin and Statins in Relation to Inflammation in Benign Prostate Tissue in the Placebo Arm of the Prostate Cancer Prevention Trial. ( Arnold, KB; Benedetti, I; De Marzo, AM; Drake, CG; Goodman, PJ; Gumuskaya, B; Hurwitz, LM; Isaacs, WB; Kulac, I; Liu, JO; Lucia, MS; Marrone, MT; Nelson, WG; Pan, F; Platz, EA; Tangen, CM; Thompson, IM; Valle, JABD, 2020) |
| " At parturition, cows were blocked by parity [multiparous (MULT) and primiparous (PRIM)] and calving ease [eutocia (EUT) and dystocia (DYS)] and were randomly assigned to 1 of 2 treatment groups: aspirin (ASP; n = 76), in which within 12 h after parturition cows received 4 treatments with acetylsalicylic acid (100 mg/kg; 2 boluses) at 12-h intervals, or placebo (PLC; n = 76), in which within 12 h after parturition cows received 4 consecutive treatments with gelatin capsules (2 capsules) containing water 12 h apart." | 5.34 | Administration of acetylsalicylic acid after parturition in lactating dairy cows under certified organic management: Part II. Biomarkers of nociception, inflammation, and stress. ( Barragan, AA; Bas, S; Bauman, LM; Coetzee, JF; Gonzalez, JDR; Lakritz, J; Menichetti, B; Piñeiro, JM; Schuenemann, GM; Velez, J, 2020) |
| "Atherosclerosis is an inflammatory response of the arterial wall to 'injury', which is prominently driven by inflammatory factors." | 5.34 | Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model. ( Li, M; Ren, H; Zhang, Y; Zhu, X, 2007) |
| "This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level." | 5.34 | Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. ( Serhan, CN; Svensson, CI; Zattoni, M, 2007) |
| "Aspirin resistance was defined when epinephrine closure time <174 s." | 5.34 | Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease. ( de Lafuente, JP; Iriarte, JA; Lafita, M; Molinero, E; Monica, S; Narvaez, I; Saez, Y; Sagastagoitia, JD; Vacas, M, 2007) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 5.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "Endothelial dysfunction, defined as a deficit in the bioavailability of nitric oxide (NO), occurs as sequelae of many vascular diseases; however, the utility of supplementing NO to obviate the extent of disease is understudied." | 5.31 | Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. ( Rudic, RD; Sessa, WC; Yu, J, 2002) |
| "Mechanical hyperalgesia was significantly reduced by the pre-treatment of 150 mg/kg, but not 50 mg/kg aspirin." | 5.31 | Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals." | 5.31 | A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Our results provide preliminary evidence that short-term aspirin and pravastatin therapy reduces hsCRP and LDL cholesterol among overweight and obese women of reproductive age, including those with low-grade inflammation." | 5.30 | Pilot randomized trial of short-term changes in inflammation and lipid levels during and after aspirin and pravastatin therapy. ( Andriessen, VC; Connell, MT; Flannagan, KS; Hill, MJ; Mumford, SL; Perkins, NJ; Plowden, TC; Radoc, JG; Schisterman, EF; Sjaarda, LA; Zolton, JR, 2019) |
| "To test the hypothesis that aspirin reduces inflammation in clinically relevant human models that recapitulate pathophysiological mechanisms implicated in the development of ARDS." | 5.24 | Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. ( Fitzgerald, M; Hamid, U; Kissenpfennig, A; Krasnodembskaya, A; Lefrancais, E; Looney, MR; McAuley, DF; McNamee, J; O'Kane, CM; Scott, C; Scott, J; Shyamsundar, M; Simpson, AJ; Verghis, R, 2017) |
| " There are indications from experimental and observational studies that aspirin may reduce inflammation associated with infection." | 5.24 | AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. ( Eisen, DP; Leder, K; Lockery, J; McBryde, ES; McNeil, JJ; Moore, EM; Pilcher, D; Wolfe, R; Woods, RL, 2017) |
| "In a nested case-control study in the Physicians' Health Study, we prospectively investigated the associations of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor receptor 2 (TNFR-2) with risk of colorectal cancer, and whether aspirin modified these associations among 268 colorectal cancer patients and 446 age- and smoking-matched controls." | 5.22 | Inflammatory biomarkers, aspirin, and risk of colorectal cancer: Findings from the physicians' health study. ( Chan, AT; Kim, C; Ma, J; Rifai, N; Sesso, HD; Stampfer, MJ; Zhang, X, 2016) |
| "ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly." | 5.22 | ASPREE-D: Aspirin for the prevention of depression in the elderly. ( Berk, M; Fitzgerald, SM; Grimm, R; Kirpach, B; Lockery, JE; McNeil, JJ; Mohebbi, M; Murray, AM; Nelson, MR; Reid, CM; Shah, RC; Storey, E; Wolfe, R; Woods, RL, 2016) |
| "Although studies have reported direct inhibition of inflammatory pathways with niacin, the effect of niacin on arterial wall inflammation remains unknown." | 5.20 | A pilot trial to examine the effect of high-dose niacin on arterial wall inflammation using fluorodeoxyglucose positron emission tomography. ( Alavi, A; deGoma, EM; Dunbar, RL; Litt, HI; Mehta, NN; Mohler, ER; Pollan, L; Rader, DJ; Saboury, B; Salavati, A; Schoen, M; Shinohara, RT; Torigian, DA; Woo, J, 2015) |
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 5.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "Using five-colour flow cytometry the platelet surface expression of CD62P and CD40L and subpopulations of leukocyte-platelet aggregates were assessed in 63 acute stroke patients and 40 healthy volunteers at baseline and after a 10-day period of aspirin intake at a daily dose of 150 mg." | 5.15 | Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. ( Dworacki, G; Golanski, J; Kozubski, W; Kufel-Grabowska, J; Lukasik, M; Michalak, S; Watala, C, 2011) |
| "Subjects consisted of 2312 men and women aged 50 to 80 years participating in the Aspirin for Asymptomatic Atherosclerosis Trial, all of whom were free of symptomatic cardiovascular disease at baseline." | 5.14 | Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia. ( Deary, IJ; Fowkes, FG; Lowe, GD; Marioni, RE; Murray, GD; Price, JF; Rumley, A; Stewart, MC, 2009) |
| "One hundred and twenty-one consecutive patients with metabolic syndrome were randomized into three groups, receiving 100 mg/day of aspirin, 300 mg/day of aspirin or a placebo, respectively, for 2 weeks." | 5.14 | Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome. ( Adhikari, CM; Gao, XR; Guo, XG; He, XY; Lin, J; Peng, LY; Zhai, YS; Zhang, LY; Zuo, ZY, 2009) |
| "Twenty-one adult patients with asthma, chronic polypoid sinusitis, and a convincing history of acute respiratory reaction to the ingestion of aspirin or nonsteroidal anti-inflammatory drugs were selected." | 5.14 | The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases. ( Alam, R; Katial, RK; Leung, R; Prasertsuntarasai, T; Strand, M; Zheng, W, 2010) |
| "This study was designed to evaluate the effects of long-term clopidogrel and aspirin administration on platelet aggregation, activation, and inflammation." | 5.13 | The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study. ( Chan, S; Madsen, EH; Maurer-Spurej, E; Saw, J, 2008) |
| "Aspirin can cause bronchoconstriction in some asthmatic patients through increased production of proinflammatory mediators, particularly leukotrienes." | 5.13 | Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma. ( Hopkinson, P; Lipworth, BJ; Meldrum, KT; Menzies, D; Nair, A, 2008) |
| "The authors recommend a low-dose aspirin regimen for primary prevention of arterial thromboembolism in patients aged 40-70 years who are at high atherosclerotic cardiovascular disease risk, or an intermediate risk with a risk-enhancer and have a low risk of bleeding." | 5.12 | Rationales and uncertainties for aspirin use in COVID-19: a narrative review. ( Aiash, H; Amin, H; Darling, E; Goweda, RA; Habeb, H; Ismail, M; Joudeh, AI; Merrell, E; Nieman, GF; Riley, JB; Sayed Ahmed, HA; Shawkat, A; Shehata, MH, 2021) |
| "Aspirin can inhibit inflammatory reactions and platelet aggregation, but little is known about the effects of the combination of aspirin plus clopidogrel, a new antiplatelet agent, on inflammation." | 5.12 | Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome. ( Chen, YG; Ji, QS; Li, RJ; Lü, RJ; Sun, Y; Xu, F; Zhang, Y, 2006) |
| "Aspirin reduces several pro-inflammatory markers in patients with coronary heart disease (CHD), while limited data exists with clopidogrel." | 5.12 | No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease. ( Arnesen, H; Pettersen, AA; Seljeflot, I; Solheim, S, 2006) |
| "Impaired antiplatelet response to clopidogrel but not to aspirin may contribute to smaller anti-inflammatory response in patients with ST-elevation myocardial infarction." | 5.12 | Relation between impaired antiplatelet response to clopidogrel and possible pleiotropic effects. ( Bobilewicz, D; Filipiak, KJ; Grabowski, M; Huczek, Z; Imiela, T; Malek, LA; Opolski, G; Spiewak, M; Szpotanska, M, 2007) |
| "Urinary 11-dehydro-TXB2, plasma sCD40 L, and sP-selectin were measured, together with indices of low-grade inflammation, glycemic control, and lipid profile, in 82 patients with type-2 diabetes and 39 without diabetes, treated with low doses of aspirin." | 5.12 | Persistent platelet activation in patients with type 2 diabetes treated with low doses of aspirin. ( Amore, C; Avanzini, F; Brero, L; de Berardis, G; de Simone, G; Dell'Elba, G; di Summa, P; Evangelista, V; Giorda, CB; Iacuitti, G; Levantesi, G; Maione, A; Manarini, S; Marelli, G; Nada, E; Nicolucci, A; Pecce, R; Pozzoli, G; Pupillo, M; Tognoni, G; Totani, L, 2007) |
| "We studied 18 558 patients with ischemic stroke, myocardial infarction, or peripheral arterial disease who participated in the trial of Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE), a study that compared the occurrence of ischemic stroke, myocardial infarction, or vascular death under randomized treatment with aspirin or clopidogrel." | 5.11 | Leukocyte count as an independent predictor of recurrent ischemic events. ( Boddy, AW; Brandt, T; Buggle, F; Dukovic, DA; Grau, AJ; Hacke, W; Lichy, C, 2004) |
| "The aim of this study was to assess the influence of aspirin on selected inflammatory markers in patients recovering from acute myocardial infarction (AMI)." | 5.10 | Influence of aspirin on inflammatory markers in patients after acute myocardial infarction. ( Arnesen, H; Eikvar, L; Hurlen, M; Seljeflot, I; Solheim, S, 2003) |
| "Experimental inflammation produces endothelial dysfunction, which can be prevented by pretreatment with aspirin." | 5.10 | Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin. ( Allen, M; Hingorani, AD; Kharbanda, RK; Klein, N; MacAllister, RJ; Vallance, P; Walton, B, 2002) |
| "Although administration of cromolyn sodium is one of the most useful drugs for the treatment of aspirin-intolerant asthma (AIA), both its pharmacologic mechanism of action and association with the pathogenesis remain obscure." | 5.09 | Cromolyn sodium suppresses eosinophilic inflammation in patients with aspirin-intolerant asthma. ( Akahori, K; Amayasu, H; Hasegawa, H; Ishizaki, Y; Nakabayashi, M; Nakagawa, H; Shoji, T; Yoshida, S, 2001) |
| "The efficacy and safety of fenoprofen calcium (Nalfon, Dista, Indianapolis, IN) and aspirin for treating acute inflammatory soft tissue injuries were compared in a 3 to 10-day randomized, double-blind, parallel study of 100 patients with bruise (1), bursitis (33), ligamentous strain (8), myofascitis (43), and tendinitis (15)." | 5.05 | Fenoprofen calcium versus aspirin in the treatment of acute inflammatory soft-tissue injuries. ( McIlwain, HH, 1985) |
| "Chronic inflammation has long been considered critical in pancreatic carcinogenesis, and recently studies showed that some anti-inflammatory agents such as aspirin could potentially be used to attenuate pancreatic carcinogenesis." | 4.95 | Inflammation-Related Pancreatic Carcinogenesis: Mechanisms and Clinical Potentials in Advances. ( Dai, JJ; Jiang, MJ; Tian, L; Wang, XP, 2017) |
| "The results of clinical studies have shown that the chronic administration of aspirin, even at the lowdoses (75-100 mg daily) recommended for the prevention of cardiovascular disease, is associated with a reduction of cancer incidence and mortality, in particular colorectal cancer (CRC)." | 4.91 | New Insights into the Mechanism of Action of Aspirin in the Prevention of Colorectal Neoplasia. ( Di Francesco, L; López Contreras, LA; Patrignani, P; Sacco, A, 2015) |
| " Moreover, the results of clinical studies have shown that the antiplatelet drug aspirin reduces the incidence of vascular events and colorectal cancer." | 4.90 | Role of platelets in inflammation and cancer: novel therapeutic strategies. ( Alberti, S; Dovizio, M; Guillem-Llobat, P; Patrignani, P, 2014) |
| " The pharmacological profiles of some hybrid lead compounds in the areas of inflammation, H(2)S-donating diclofenac (ACS 15); cardiovascular, H(2)S-donating aspirin (ACS 14); urology, H(2)S-donating sildenafil (ACS 6); and neurodegenerative, H(2)S-donating latanoprost (ACS 67) for glaucoma treatment and H(2)S-donating levodopa (ACS 84) for Parkinson's disease, are described." | 4.87 | Therapeutic potential of new hydrogen sulfide-releasing hybrids. ( Del Soldato, P; Giustarini, D; Rossi, R; Santus, G; Sparatore, A, 2011) |
| " From recent studies on the U-LTE(4) associated with adult stable asthma we identified four factors for hyperleukotrieneuria, namely, aspirin intolerance, eosinophilic nasal polyposis (ENP), vasculitis, and severe asthma." | 4.84 | Hyperleukotrieneuria in patients with allergic and inflammatory disease. ( Akiyama, K; Higashi, N; Mita, H; Ono, E; Taniguchi, M, 2008) |
| "Lipoxins and aspirin-triggered lipoxins are lipid mediators generated from arachidonic acid that act to reduce inflammation and promote resolution." | 4.83 | Lipoxins and new lipid mediators in the resolution of inflammation. ( Schwab, JM; Serhan, CN, 2006) |
| "Aspirin and the other NSAIDs have popularized the notion of inhibiting prostaglandins as a common anti-inflammatory strategy based on the erroneous premise that all eicosanoids are, within the context of inflammation, generally detrimental." | 4.83 | COX-2 in inflammation and resolution. ( Gilroy, DW; Rajakariar, R; Yaqoob, MM, 2006) |
| " Arachidonic acid metabolites seem to be particularly important in the pathogenesis of nasal polyps in patients with aspirin hypersensitivity rhinosinusitis/asthma syndrome." | 4.82 | Pathogenesis of nasal polyps: an update. ( Kowalski, ML; Lewandowska-Polak, A; Pawliczak, R, 2005) |
| "Current trends of pharmacological research on inflammation are outlined, with particular reference to some agents differing from the aspirin-like and the corticosteroids in their mode and mechanism of action." | 4.77 | Current trends in the research on antiinflammatory agents. ( Bertelli, A; Silvestrini, B, 1985) |
| "Dual pathway inhibition (DPI) with low-dose rivaroxaban and aspirin in patients with coronary artery disease (CAD) and/or peripheral artery disease (PAD) reduces the occurrence of cardiovascular (CV) events; however, the underlying mechanisms explaining these latter CV benefits are not clearly understood." | 4.31 | Dual Pathway Inhibition with Rivaroxaban and Aspirin Reduces Inflammatory Biomarkers in Atherosclerosis. ( Attena, E; Cotticelli, C; D'Alterio, G; D'Onofrio, A; Fabiani, D; Golino, P; Leonardi, S; Maione, B; Nigro, G; Rago, A; Russo, V; Sarpa, S, 2023) |
| "We isolated extracellular vesicles (EVs) from periodontal stem cells (PDLSCs) and loaded with aspirin by sonication, and then evaluated the treatment efficacy of aspirin-loaded vesicles (EVs-ASP) in periodontitis model in mice." | 4.31 | Aspirin loaded extracellular vesicles inhibit inflammation of macrophages via switching metabolic phenotype in periodontitis. ( Da, N; He, X; Li, B; Shi, Y; Wang, Y; Yang, J; Zhang, R, 2023) |
| "Chronic inflammation contributes to several diseases, but its resolution is driven by specialized pro-resolving mediators (SPM) such as resolvin D1 (RvD1) and its epimer aspirin-triggered resolvin D1 (AT-RvD1), both biosynthesized from ω-3 fatty docosahexaenoic acid (DHA)." | 4.31 | ALX/FPR2 Activation by Stereoisomers of D1 Resolvins Elucidating with Molecular Dynamics Simulation. ( Abrahão, O; Nunes, VS; Rogério, AP; Serhan, CN, 2023) |
| "Platelets are key contributors to allergic asthma and aspirin-exacerbated respiratory disease (AERD), an asthma phenotype involving platelet activation and IL-33-dependent mast cell activation." | 4.31 | Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease. ( Amin, T; Boyce, JA; Cahill, KN; Feng, C; Foer, D; Hayashi, H; Lai, J; Laidlaw, TM; Lin, A; Liu, T; McGill, A; Nagai, J; Newcomb, DC; Niswender, KD; Snyder, WE; Tani, Y, 2023) |
| "To investigate the effect of Aspirin Triggered-Resolvin D1 (AT-RvD1) as an anti-pyroptosis and anti-inflammatory agent on lipopolysaccharide (LPS) induced acute keratitis in Wistar rats." | 4.12 | The inhibiting effect of Aspirin Triggered-Resolvin D1 in non-canonical pyroptosis in rats with acute keratitis. ( Ke, B; Liu, M; Wang, P; Yuan, Y; Zhu, C, 2022) |
| " procera dried latex extract prepared in methanol (MeDL) against inflammation and oxidative stress in experimental model of colorectal carcinoma (CRC)." | 4.12 | Anti-inflammatory and antioxidant effect of methanol extract of latex of Calotropis procera in rat model of colorectal cancer. ( Das, P; Kumar, VL; Verma, S, 2022) |
| " Aspirin is known as a potent anti-inflammatory drug, but its role in adipogenesis, adipocyte-specific inflammation, and metabolic syndrome is not well characterized." | 4.12 | Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice. ( Ahmed, F; Amin, MT; Begum, R; Bhowmik, DR; Hossain, MS; Islam, MA; Roy, S, 2022) |
| "Aspirin inhibited carcinogenesis of intestinal mucosal cells in the ulcerative colitis model by inhibiting the interleukin-6/ Janus kinase/signal transducer and activator of transcription 3 signaling pathway and promoted apoptosis, thereby suppressing proliferation." | 4.12 | Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through Inhibiting IL-6/JAK/STAT3 Signaling Pathway and Modulating Apoptosis and Proliferation. ( Chen, Y; Diao, T; Li, D; Shang, G; Shi, L; Sun, L; Yin, X, 2022) |
| "The role of chronic inflammation and arachidonic acid (AA) metabolism in tumor progression has been well characterized for variety of cancers, with compelling data for colon cancer." | 4.12 | Targeting the Leukotriene Pathway for Colon Cancer Interception. ( Mohammed, A; Shoemaker, RH, 2022) |
| " Here, we report the case of an 82-year-old Japanese woman with normal renal function who developed multiple cerebral infarctions due to CAT that grew rapidly, associated with inflammation from an antecedent infection, and diminished rapidly by detachment of fibrin on the mass surface and antithrombotic drugs." | 4.12 | Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report. ( Doyu, M; Ito, H; Kimura, M; Matsuyama, K; Niwa, JI, 2022) |
| "To determine the impact of low-dose aspirin (81 mg) on markers of maternal inflammation and placental function." | 4.12 | The impact of low-dose aspirin on markers of inflammation and placental function: an ancillary study of the ASPIRIN trial. ( Araganji, R; Goudar, SS; Hoffman, MK; Kavi, A; Somannavar, MS; Vernekar, SS, 2022) |
| " Therapeutic strategies using lipid mediators, such as aspirin-triggered resolvin D1 (ATRvD1), can contribute to the resolution of acute and chronic inflammation." | 4.02 | ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice. ( Almeida-Souza, F; Benjamim, CF; Calabrese, KS; Calcia, TBB; Caruso-Neves, C; Guilherme, RF; Lemos, FS; Neves, JS; Silva, CP; Silva, JBNF, 2021) |
| "Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) asthma is characterized by chronic rhinosinusitis and intolerance of aspirin and other COX1 inhibitors." | 4.02 | Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease. ( Bochenek, G; Gielicz, A; Jakiela, B; Plutecka, H; Przybyszowski, M; Rebane, A; Sladek, K; Soja, J, 2021) |
| "To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO." | 4.02 | Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO). ( Gao, J; Huang, L; Wang, J, 2021) |
| "Plasma from women with pre-eclampsia induced TBARS and nitrotyrosine production on endothelial and U937 cells." | 3.96 | Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia. ( Alvarez, AM; Cadavid J, AP; Gil-Villa, AM; Rojas-López, M; Velásquez-Berrío, M, 2020) |
| "Beside its therapeutic role in the thrombotic vascular events, Clopidogrel confers significant protection against ischemic myocardial injury by counteracting the platelet-mediated inflammation and oxidative stress associated with HFD-C consumption in animals." | 3.96 | Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice. ( Korish, AA, 2020) |
| "Epidemiologic studies have linked the use of aspirin to a decline in chronic inflammation that underlies many human diseases, including some cancers." | 3.91 | Discovery of aspirin-triggered eicosanoid-like mediators in a ( Chou, J; Goncharuk, T; Govind, S; John, G; Moore, RS; Paddibhatla, I; Panettieri, S; Rajwani, R, 2019) |
| "To investigate the dynamic changes of platelet-derived microparticles (PDMP) in Kawasaki disease (KD) and its clinical significance and to study its relationship with intravenous immunoglobulin (IVIG) resistance, inflammatory indicators and aspirin treatment in children with KD." | 3.91 | Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation and Inflammation in Kawasaki Disease. ( Fan, Z; Huang, N; Jin, J; Lu, Y; Ma, L; Wang, J; Yu, H, 2019) |
| "To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers." | 3.91 | New drug candidates for depression - a nationwide population-based study. ( Andersen, PK; Berk, M; Ekstrøm, CT; Gerds, TA; Kessing, LV; Rytgaard, HC, 2019) |
| "Influence of pre-existing treatment with aspirin and/or statins prior to a first acute coronary syndrome (ACS) on clinical presentation, infarct size and inflammation markers." | 3.91 | Pre-existing treatment with aspirin or statins influences clinical presentation, infarct size and inflammation in patients with de novo acute coronary syndromes. ( Denegri, A; Lüscher, TF; Mach, F; Matter, CM; Muller, O; Obeid, S; Räber, L; Shahin, M; Weidmann, L; Yousif, N, 2019) |
| "In the present study, we aimed to evaluate the role of aspirin-triggered resolvin D1 (AT-RvD1) in paraquat (PQ)-induced acute lung injury (ALI) in mice." | 3.91 | Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice. ( Hu, X; Shen, H; Wang, Y; Zhang, L; Zhao, M, 2019) |
| "Circulating MPA are a robust marker of platelet activity and monocyte inflammation, unaffected by low-dose aspirin, and are significantly elevated in subjects with CVD, particularly those with PAD." | 3.91 | Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease. ( Allen, N; Barrett, TJ; Berger, JS; Guo, Y; Hochman, JS; Nardi, M; Ramkhelawon, B; Rockman, CB, 2019) |
| " We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of tumor infiltrating immune cells, and survival in colorectal cancer (CRC), and these relationships could be altered by aspirin use." | 3.91 | Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer. ( Herzig, KH; Karhu, T; Karttunen, TJ; Klintrup, K; Mäkelä, J; Mäkinen, MJ; Minkkinen, I; Sirniö, P; Tuomisto, A; Väyrynen, JP; Väyrynen, SA, 2019) |
| "After aspirin treatment, the inflammation and scar formation in injury tendon were significantly inhibited by aspirin." | 3.91 | Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway. ( Chen, W; He, G; Kang, X; Lyu, J; Mu, M; Shi, Y; Tang, H; Tang, K; Wang, Y; Yang, M; Zhang, J; Zhou, B; Zhou, M; Zhu, M, 2019) |
| "Artesunate markedly ameliorated aspirin induced gastric injury in rats by targeting oxidative stress and COX-2 dependent as well as COX-2 independent proinflammatory signaling pathways and could have a therapeutic potential in gastric ulcer disease." | 3.88 | Artesunate affords protection against aspirin-induced gastric injury by targeting oxidative stress and proinflammatory signaling. ( Kumar, VL; Verma, S, 2018) |
| "BackgroundHigh-dose aspirin (HDA) is used with intravenous immunoglobulin (IVIg) in Kawasaki disease (KD)." | 3.88 | Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease. ( Binstadt, BA; Braunlin, EA; Migally, K; Zhang, L, 2018) |
| "Clinical features of aspirin-exacerbated respiratory disease (AERD) are characterized by overproduction of cysteinyl leukotrienes (LT) and eosinophil activation, in which epithelial cells contribute to eosinophilic airway inflammation." | 3.88 | Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease. ( Choi, Y; Kim, HM; Kim, SH; Park, HS; Pham, DL; Trinh, HKT, 2018) |
| "01) decreased the paw oedema volume and granuloma dry weight as compared to control and it was comparable to that of aspirin and histopathological sections showed a decrease in granulation tissue formation as compared to control." | 3.88 | Effect of anti-inflammatory activity of ranolazine in rat model of inflammation. ( Davangeri, R; Hashilkar, NK; Majagi, SI; Naveena, R, 2018) |
| " The goal of this study was to determine whether systemic preventive treatment with Aspirin-triggered RvD1 (AT-RvD1) reduces inflammation and preserves secretory functioning in NOD/ShiLtJ SS-like mice." | 3.85 | AT-RvD1 Promotes Resolution of Inflammation in NOD/ShiLtJ mice. ( Baker, OJ; Easley, JT; Maruyama, CL; Trump, BG; Wang, CS, 2017) |
| " In a cross-sectional study of 787 patients with newly diagnosed clinical stage IB or II melanoma, we estimated odds ratios for the association of proinflammatory factors (high body mass index, diabetes, cardiovascular disease, hypertension, and smoking) or the use of anti-inflammatory medications (statins, aspirin, corticosteroids, and nonsteroidal anti-inflammatory drugs), with ulcerated primary melanoma using regression models and subgroup analyses to control for melanoma thickness and mitotic rate." | 3.85 | Associations of Statins and Diabetes with Diagnosis of Ulcerated Cutaneous Melanoma. ( Green, AC; Hughes, MCB; Khosrotehrani, K; Malt, M; Smith, D; Smithers, BM; van der Pols, JC; von Schuckmann, LA, 2017) |
| "There is a genetic association between polymorphisms of genes involved in the synthesis of proteins related to arachidonic acid metabolism (LTC4S, ALOX5), antigen presentation (HLA), inflammation (IL5, IL17), and aspirin metabolism (CYP2C19)." | 3.85 | Physiopathology and genetics in aspirin-exacerbated respiratory disease. ( Falfán-Valencia, R; Pavón-Romero, GF; Ramírez-Jiménez, F; Roldán-Alvarez, MA; Terán, LM, 2017) |
| " The goal of this study was to encapsulate Aspirin-Triggered Resolvin D1 (AT-RvD1) into a degradable biomaterial in order to elucidate the effects of sustained, localized delivery in a model of sterile inflammation." | 3.85 | Aspirin-Triggered Resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling. ( Botchwey, EA; Olingy, CE; San Emeterio, CL; Sok, MCP; Tria, MC, 2017) |
| " Aspirin has many properties including anti-inflammation and anti-cancer." | 3.83 | Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma. ( Aukkanimart, R; Boonmars, T; Jiraporn, S; Loilome, W; Nadchanan, W; Namwat, N; Ruangjirachuporn, W; Sriraj, P; Sudsarn, P, 2016) |
| "We measured serum levels of proinflammatory/prothrombotic markers P-selectin, CD40L, matrix metalloproteinase 9 (MMP-9), intracellular adhesion molecule 1 (ICAM-1), and interleukin (IL)-6 in ischemic stroke patients, correlating their levels with the results of aspirin (ASA) and clopidogrel antiplatelet responses, using 3 "point of care" platelet function instruments, thromboelastograph (TEG), Accumetrics (ACU), and impedance aggregometer (IMP)." | 3.83 | Relationship between Inflammation and Aspirin and Clopidogrel Antiplatelet Responses in Acute Ischemic Stroke. ( Ambrus, JL; Chichelli, T; Ching, M; Janicke, D; Munschauer, F; Sawyer, R; Sternberg, D; Sternberg, Z; Yu, J, 2016) |
| " The use of low doses of aspirin inhibits platelet aggregation and inflammation and prevents cardiovascular mortality." | 3.83 | Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: Comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid. ( Beutler, H; Brusco, I; de Almeida, AS; de Oliveira, SM; Duarte, MM; Duarte, T; Hirsch, GE; Klafke, JZ; Nascimento, S; Parisi, MM; Pereira, RL; Porto, FG; Rubin, FH; Schmidt, A; Trevisan, G; Viecili, PR, 2016) |
| " Concentration of sTWEAK in HF-REF was affected by white blood cell count and aspirin intake, while sCD163 by exercise capacity, LV diastolic volume, CRP and presence of arterial hypertension." | 3.83 | Alterations of soluble TWEAK and CD163 concentrations in patients with chronic heart failure. ( Galar, B; Jakim, P; Jasiewicz, M; Kaminski, KA; Lisowska, A; Marcinkiewicz-Siemion, M; Miklasz, P; Musial, WJ; Ptaszynska-Kopczynska, K; Waszkiewicz, E; Witkowski, M, 2016) |
| "The patent data revealed the antinociceptive and anti-inflammatory potentials of the methanolic leaves extract of Lannea schimperi which could be beneficial in alleviating painful inflammatory conditions." | 3.83 | Phytochemistry, Antinociceptive and Anti-inflammatory Actvities of Methanolic Leaves Extract of Lannea schimperi (Hoschst. Ex Rich) ENG. ( Adamu, M; Akumka, DD; Egbe, EO; Mikail, HG, 2016) |
| "Within this retrospective observational spontaneous clinical study 44 patients (31 males and 13 females) all presenting stable coronary artery disease were evaluated; 25 subjects were treated with only acetylsalicylic acid and/or clopidogrel in association with statins (standard therapeutic protocol) while for the other 18 subjects the standard therapeutic protocol was integrated with Arnica comp." | 3.83 | Effects of Arnica comp.-Heel® on reducing cardiovascular events in patients with stable coronary disease. ( Bianchi, M; Di Nardo, V; Fioranelli, M; Roccia, MG, 2016) |
| "To explore the effects of aspirin and inflammation on the maturation and function of dendritic cells (DC) on the supernatant of VX-2 squamous cell carcinoma." | 3.83 | [Effects of aspirin on dendritic cells in the inflammatory microenvironment of rabbit buccal VX-2 squamous cell carcinoma]. ( Chen, Z; Huang, G; Yao, L; Yi, J; Zhang, L; Zhang, N, 2016) |
| "miR-145 is involved in the anti-proliferation and anti-inflammation effects of aspirin on VSMCs by inhibiting the expression of CD40." | 3.83 | miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40. ( Chen, M; Guo, R; Guo, X; Peng, X; Wu, T; Yu, L; Zhang, B, 2016) |
| "Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors." | 3.83 | Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease. ( Chung, IY; Gi Uhm, T; Kong, SK; Park, CS; Soo Chang, H; Soo Kim, B; Sook Park, J; Woo Park, S, 2016) |
| "Chronic inflammation is a risk factor for the onset of cancer and the regular use of aspirin reduces the risk of cancer development." | 3.83 | Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate. ( Brighenti, E; Derenzini, M; Fornari, F; Giannone, FA; Govoni, M; Montanaro, L; Onofrillo, C; Treré, D, 2016) |
| "Aspirin has a clear anti-inflammatory effect and is used as an anti-inflammatory agent for both acute and long-term inflammation." | 3.83 | Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. ( Ding, Y; Gao, L; Li, W; Liu, G; Liu, J; Lu, G; Pan, Y; Tong, Z; Tu, J; Wang, Y, 2016) |
| " Factors reported to modify systemic inflammation (low vitamin D levels, high body mass index, use of aspirin or nonsteroidal anti-inflammatory drugs or smoking were tested as predictors of microscopic ulceration (in which primary tumors are inflamed) and melanoma-specific survival (MSS)." | 3.81 | 25-Hydroxyvitamin D2 /D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort. ( Bishop, DT; Chan, M; Davies, JR; Gascoyne, J; Haynes, S; Latheef, F; Newton-Bishop, JA; O'Donovan, C; Randerson-Moor, J; Waseem, S, 2015) |
| "To characterize platelet function and responsiveness to aspirin in relation to thrombogenesis, systemic inflammation, and markers of endothelial function in adults with Fontan circulation (FC)." | 3.81 | Aspirin resistance in adult patients after Fontan surgery. ( Chłopicki, S; Komar, M; Musiałek, P; Olszowska, M; Pajak, J; Podolec, J; Podolec, P; Rubis, P; Sitek, B; Tomkiewicz-Pajak, L; Wojcik, T, 2015) |
| "Aspirin-exacerbated respiratory disease (AERD) is an endotype of severe and eosinophilic adult asthma characterized by chronic rhinosinusitis with nasal polyps and hypersensitivity to aspirin and/or nonsteroidal anti-inflammatory drugs." | 3.81 | Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype. ( Choi, H; Kim, SH; Park, HS; Ye, YM; Yoon, MG, 2015) |
| " The results showed that amygdalin and cinnamic acid inhibit serine phosphorylation of IRS-1 through targeting JNK serine kinase and enhance insulin sensitivity." | 3.81 | Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance. ( Kim, MJ; Rangasamy, S; Shim, Y; Song, JM, 2015) |
| "Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and inflammation." | 3.81 | Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses. ( Agresti, A; Antonyak, M; Bianchi, ME; Cerione, RA; Choi, HW; De Marchis, F; Gentile, DR; Gorzanelli, A; Hamilton, K; Klessig, DF; Manohar, M; Micikas, RJ; Montelione, GT; Moreau, M; Park, SW; Preti, A; Schroeder, FC; Song, F; Swapna, GV; Tian, M; Venereau, E; Wang, H, 2015) |
| " A growing body of evidence reveals that aspirin is a potent antioxidant and anti-inflammation drug." | 3.80 | Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis. ( Chen, JW; Cheng, YH; Chien, Y; Chiou, SH; Hsiao, CY; Huang, PH; Kao, CL; Leu, HB; Liao, YW; Lin, SJ; Tsai, KL; Wang, CY; Yang, YP, 2014) |
| "Investigate the therapeutic effect of regional arterial infusion (RAI) with Aspirin-Triggered Lipoxin A4 (ATL) in experimental severe acute pancreatitis (SAP) in rats." | 3.80 | Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis. ( Andersson, R; Chen, B; Jin, Y; Sun, H; Wang, W; Xie, J; Xie, Y; Xu, D; Yang, F; Zhou, M, 2014) |
| "Aspirin was first used for patients with Kawasaki disease(KD) at 1970s." | 3.80 | [Aspirin treatment for patients with Kawasaki disease]. ( Hamada, H, 2014) |
| "Inflammation has been postulated to modify the platelet response to aspirin treatment, thereby causing high on-treatment residual platelet reactivity (HRPR)." | 3.79 | Differential impact of inflammation on six laboratory assays measuring residual arachidonic acid-inducible platelet reactivity during dual antiplatelet therapy. ( Gremmel, T; Kopp, CW; Koppensteiner, R; Panzer, S; Perkmann, T; Seidinger, D; Steiner, S, 2013) |
| "Poncirus trifoliate is a traditional Chinese medicinal plant used for treating inflammation-related diseases for a long time and trifoliate orange contains abundant auraptene." | 3.79 | Anti-inflammatory effect of auraptene extracted from trifoliate orange (Poncirus trifoliate) on LPS-stimulated RAW 264.7 cells. ( Deng, X; Ma, Z; Peng, S; Yan, H, 2013) |
| " Long-term administration of cilostazol is more effective in reducing neointimal formation at non-overlapping segments of BESs in a porcine coronary model." | 3.79 | The impact of triple anti-platelet therapy for endothelialization and inflammatory response at overlapping bioabsorbable polymer coated drug-eluting stents in a porcine coronary model. ( Ahn, Y; Cho, JG; Hong, YJ; Jeong, MH; Kang, JC; Kim, JH; Kim, JM; Kim, KH; Lee, KH; Lim, KS; Park, DS; Park, HW; Park, JC; Park, KH; Sim, DS; Yoon, HJ; Yoon, NS, 2013) |
| "Tumor-associated inflammation is a driving force in several adult cancers and intake of low-dose aspirin has proven to reduce cancer incidence." | 3.79 | Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. ( Carlson, LM; Idborg, H; Jakobsson, PJ; Kogner, P; Rasmuson, A; Segerström, L; Sveinbjörnsson, B, 2013) |
| "Collectively, these findings highlight the combination of Docosahexaenoic Acid and Aspirin as a possible measure against inflammation of the nervous system, thus leading to protection against neurodegenerative diseases with an inflammatory etiology." | 3.79 | Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin. ( Pettit, LK; Tadros, J; Varsanyi, C; Vassiliou, E, 2013) |
| "Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC." | 3.77 | Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. ( Chen, H; Gao, W; Mao, X; Ren, C; Song, T; Tian, Y; Wang, D; Ye, Y, 2011) |
| "E-series resolvins are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis." | 3.77 | Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. ( Oh, SF; Pillai, PS; Recchiuti, A; Serhan, CN; Yang, R, 2011) |
| " Lipoxins (LXs) and aspirin-triggered LXs (ATLs) are considered to act as 'braking signals' in inflammation." | 3.77 | Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells. ( Li, LY; Liu, RG; Shang, Y; Wang, YP; Wu, Y; Yao, SL; Yuan, SY; Zheng, J; Zhou, JP, 2011) |
| "Inflammation is a multi-staged process whose expansive phase is thought to be driven by acutely released arachidonic acid (AA) and its metabolites." | 3.76 | Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. ( Chiamvimonvat, N; Hammock, BD; Hwang, SH; Inceoglu, B; Liu, JY; Qiu, H; Ulu, A; Yang, J, 2010) |
| "Although its role to prevent secondary cardiovascular complications has been well established, how acetyl salicylic acid (ASA, aspirin) regulates certain key molecules in the atherogenesis is still not known." | 3.76 | Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages. ( Gan, L; Jiang, Y; Li, L; Liu, H; Lu, L; Peng, J; Shen, L; Su, C; Zhang, L; Zhang, Q, 2010) |
| " Here, we have assessed the role played by NO, formed by inducible NOS (iNOS), in the inflammation induced by aspirin in the gut, by modulating HIF-1 activity." | 3.76 | Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1alpha in macrophages during aspirin-induced mesenteric inflammation. ( Barrachina, MD; Calatayud, S; Díez, I; Esplugues, JV; Hernández, C; O'Connor, JE; Quintana, E, 2010) |
| "These findings suggest that ASA changes Th17-type into Th2-type inflammation mainly via the adenosine and uric acid metabolic pathway in the lung." | 3.76 | Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. ( Gyu Jeon, S; Kim, YK; Kim, YS; Moon, HG; Oh, SY; Song Gho, Y; Tae, YM; Zhu, Z, 2010) |
| " The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation." | 3.75 | Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. ( Dercho, RA; Di Francesco, A; Di Francesco, L; Dovizio, M; Evangelista, V; Pandolfi, A; Patrignani, P; Piccoli, A; Salvatore, T; Seta, F; Totani, L, 2009) |
| "In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction." | 3.75 | The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009) |
| "The Aspirin/Folate Polyp Prevention Trial found that aspirin, but not folic acid, reduced recurrence of colorectal adenomas." | 3.75 | Antagonistic effects of aspirin and folic acid on inflammation markers and subsequent risk of recurrent colorectal adenomas. ( Ahnen, DJ; Baron, JA; Barry, EL; Bresalier, RS; Cushman, M; Ho, GY; McKeown-Eyssen, G; Rohan, TE; Saibil, F; Sandler, RS; Xue, X, 2009) |
| "Substituted thiazoles with different structural features were synthesized and screened for their anti-inflammatory activity in acute carrageenin induced rat paw edema model and chronic formalin induced rat paw edema model." | 3.74 | 2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. ( Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S, 2008) |
| " Often it is associated with non allergic rhinitis with eosinophilia syndrome (NARES), nasal polyposis and intolerance to Aspirin and NSAID's." | 3.74 | [Nonallergic diseases of the upper and lower airways]. ( Menz, G; Rothe, T, 2008) |
| "Formation of reactive oxygen species and mitochondrial/lysosomal damages were significantly inhibited by both acetylsalicylic acid and celecoxib in hepatocytes of all pain- suffering animals." | 3.74 | Involvement of subcellular organelles in inflammatory pain-induced oxidative stress and apoptosis in the rat hepatocytes. ( Ahmadiani, A; Pourahmad, J; Rasekh, HR; Rezaei, M, 2008) |
| "The purpose of this work was to evaluate the antinociceptive efficacy of an optimal morphine and metamizol combination on different levels of nociception (levels I, II, and III) using the "Pain-induced functional impairment model in the rat"." | 3.74 | The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain. ( Cortés-Arroyo, AR; Domínguez-Ramírez, AM; Godínez-Chaparro, B; Guevara-López, U; Huerta-Cruz, JC; López-Muñoz, FJ, 2008) |
| "It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy." | 3.74 | Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. ( Hatala, DA; Howell, SJ; Huang, K; Kern, TS; Zheng, L, 2007) |
| "Effects of different doses of aspirin, compared to equimolar doses of nitric oxide (NO)-donating aspirin (NCX 4016), and of a single dose of paracetamol, compared to an equimolar dose of NO-donating paracetamol (NCX 701) were investigated in acute zymosan-induced air pouch inflammation in rats." | 3.74 | Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats. ( Mamuk, S; Melli, M, 2007) |
| "In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition." | 3.74 | Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. ( Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2008) |
| " The aims of the present study were: to verify the incidence of Normal Weight Obese (NWO) syndrome; to evaluate by PINI the effect of 8 weeks acetyl salicylic (100 mg/die) and atorvastatin (10 mg/die) combined treatment on chronic inflammation in 52 selected HD patients." | 3.74 | Anti-inflammatory effects of combined treatment with acetyl salicylic acid and atorvastatin in haemodialysis patients affected by Normal Weight Obese syndrome. ( De Angelis, S; De Lorenzo, A; Di Daniele, N; Di Renzo, L; Miani, N; Noce, A; Tozzo, C, 2008) |
| "In the nociception test, the pain-induced functional impairment rat model, uric acid at 3." | 3.73 | Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005) |
| " Gaultherin, 2-[(6-O-beta-D-Xylopyranosyl-beta-D-glucopyranosyl)oxy] benzoic acid methyl ester, a natural salicylate derivative extracted from Gaultheria yunnanensis, has been shown to have analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to aspirin in our primary study." | 3.73 | Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug. ( Ding, Y; Du, GH; He, XL; Zhang, B, 2006) |
| "To address the hypothesis that expression of 1 or more EP receptors on nasal mucosal inflammatory cells is deficient in patients with aspirin-sensitive compared with nonaspirin-sensitive polypoid rhinosinusitis." | 3.73 | Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells. ( Corrigan, CJ; Lee, TH; Meng, Q; Parikh, A; Scadding, G; Ying, S, 2006) |
| "Several studies have suggested the involvement of an autoimmune mechanism in aspirin (ASA)-intolerant asthma." | 3.73 | Circulating autoantibodies in patients with aspirin-intolerant asthma: an epiphenomenon related to airway inflammation. ( Choi, JH; Kim, SH; Nahm, DH; Park, HS; Suh, CH; Ye, YM, 2006) |
| "We report the cases of two patients who had a favorable outcome with aspirin and corticosteroid therapy during pregnancy for chronic villitis of unknown etiology complicated by labor asphyxia and further intrauterine fetal demise in one gravida 3 patient and for chronic intervillositis of unknown etiology diagnosed after three perinatal deaths in another patient (gravida 4)." | 3.73 | [Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology]. ( Alnoukari, F; Barrier, J; Boog, G; Jossic, F; Le Vaillant, C; Muller, JY, 2006) |
| " In vivo studies by encapsulating anti-inflammatory agents (aspirin and naproxen) in these polymeric nanomicelles and by applying topically resulted in significant reduction in inflammation." | 3.72 | Supramolecular assemblies based on copolymers of PEG600 and functionalized aromatic diesters for drug delivery applications. ( Chen, MH; Kumar, J; Kumar, R; Nicolosi, R; Parmar, VS; Samuelson, LA; Watterson, AC; Yoganathan, S, 2004) |
| " It is here reported that LXA(4), LXB(4), the aspirin-triggered LX (ATL) epimer, 15-epi-LXB(4), and a stable synthetic analogue 15(R/S)-methyl-LXA(4) stimulate phagocytosis of exogenously administered excess apoptotic PMN by macrophages (M phi) in vivo in a classic model of acute inflammation, namely thioglycollate-induced peritonitis." | 3.71 | Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. ( Berlasconi, G; Brady, HR; Cottell, D; Erwig, L; Godson, C; Harvey, K; Mitchell, S; Petasis, NA; Rees, AJ; Reville, K; Savill, J; Thomas, G, 2002) |
| "In men with hypercholesterolemia simvastatin treatment lowers serum levels of CRP and proinflammatory cytokines." | 3.71 | Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia. ( Gajewski, P; Jankowski, M; Musial, J; Sydor, W; Szczeklik, A; Undas, A, 2001) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 3.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| " Since the non-steroidal anti-inflammatory agents, indomethacin and aspirin, were inactive, cyclooxygenase products are not involved in the anaphylactic reaction in boosted or unboosted mice." | 3.69 | Involvement of leukotrienes in allergic inflammation in mice. ( Cordeiro, RS; Vargaftig, BB; Zuany-Amorim, C, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The inflammatory cell infiltrate in bronchial biopsies of 12 aspirin-sensitive asthmatic (ASA) subjects and eight non-aspirin-sensitive (non-ASA) control subjects have been compared." | 3.69 | Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. ( Barker, J; Christie, PE; Lee, TH; Nasser, SM; Pfister, R; Schmitz-Schumann, M; Sousa, AR, 1996) |
| "This study, performed in freely moving rats, evaluates the effects of the two most prescribed analgesics, aspirin and acetaminophen, on carrageenin inflammation and the associated c-Fos expression in the rat lumbar spinal cord." | 3.69 | Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation. ( Besson, JM; Buritova, J; Honoré, P, 1995) |
| "Serum salicylate concentrations were measured in 60 patients with acute phase Kawasaki disease (KD), who were treated with intravenous aspirin (IVASP), to evaluate its anti-inflammatory effect in the treatment of KD." | 3.68 | Treatment of Kawasaki disease using the intravenous aspirin anti-inflammatory effect of salicylate. ( Matsuo, N; Saji, T; Umezawa, T, 1992) |
| "The effect of combination NSAID therapy of tilomisole with aspirin or naproxen was studied in rats with carrageenan-induced paw edema and established adjuvant arthritis." | 3.68 | Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat. ( Calhoun, W; Carlson, RP; Copenhaver, TW; Datko, LJ; Gilman, SC, 1992) |
| "Sequential potentiation of antiinflammatory activity of dexamethasone was obtained by co-administration of diclofenac-Na (and indomethacin), but not of phenylbutazone and, apparently, of acetylsalicylic acid (ASA) in the carrageenin rat paw edema." | 3.67 | On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis. ( Bekemeier, H; Hirschelmann, R, 1986) |
| "Acetylsalicic acid and indomethacin suppress the increase of alpha-amanitin sensitive RNA synthesis (pre-mRNA), but not that of alpha-amanitin resistant RNA synthesis (pre-rRNA), which occur in liver nuclei a few hours after the start of turpentine-induced inflammation in the skin." | 3.67 | Prostaglandin synthesis and early biochemical events in the liver cells during the acute-phase response. ( Aletti, MG; Bernelli-Zazzera, A; Ferioli, ME; Piccoletti, R; Scalabrino, G, 1987) |
| "In cats with an acute experimental inflammation in the right knee joint the effects of acetylsalicylic acid (ASA) and indomethacin on the discharge properties of single fine myelinated and unmyelinated articular afferent units were tested." | 3.67 | Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints. ( Heppelmann, B; Pfeffer, A; Schaible, GH; Schmidt, RF, 1986) |
| "A mode of interaction of bradykinin with prostaglandins (PGs) in pain were compared with that in acute inflammation." | 3.67 | Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation. ( Harada, Y; Hori, Y; Katori, M; Tanaka, K; Uchida, Y, 1986) |
| " Aspirin also reduced the levels of PGE2 and TXB2 in the exudate but did not consistently affect PMN influx, thereby confirming that inhibition of cyclo-oxygenase does not reduce cell migration in inflammation." | 3.66 | The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. ( Moncada, S; Salmon, JA; Simmons, PM, 1983) |
| "The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation." | 3.66 | Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat. ( Brooks, PM; Garrett, R; Manthey, B; Vernon-Roberts, B, 1983) |
| " Indomethacin inhibited the carrageenin-oedema in normal rats, but failed to further suppress the poorly developed delayed phase of the carrageenin-induced inflammation in EFAD rats." | 3.65 | Effects of anti-inflammatory drugs on the carrageenin-induced hind paw inflammation of rats deprived of endogenous precursors of prostaglandins. ( Bonta, IL; Bult, H, 1977) |
| "One hundred analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti-inflammatory tests and the 2-phenyl-1,4-benzoquinone writhing and inflamed paw pressure analgesic tests." | 3.65 | Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs. ( Child, RG; Osterberg, AC; Sloboda, AE; Tomcufcik, AS, 1977) |
| "Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin, and phenylbutazone, but not the activity of sodium salicylate or hydrocortisone, in the carrageenan pleurisy or hindlimb models of inflammation in the rat." | 3.65 | Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat. ( Ellis, CH; Selph, JL; Truax, JF; Vinegar, R; Welch, RM; White, HL, 1976) |
| "Glycogen in isotonic saline was infused into the peritoneal cavities of rabbits to produce sterile inflammation." | 3.65 | Changes in the concentration of leucocytes and platelets in the peripheral blood during sterile inflammation in rabbits. ( Born, GV; Ng, LF; Zuzel, M, 1977) |
| "Evidence for the effectiveness of ketoprofen in animal models of inflammation and its antipyretic effect is reviewed." | 3.65 | Some pharmacological and toxicological studies on ketoprofen. ( Ducrot, R; Guyonnet, JC; Julou, L; Pasquet, J, 1976) |
| "The mechanism of action of aspirin and similar drugs and the role of prostaglandins in the pathogenesis of inflammation are being actively studied." | 3.65 | Prostaglandins, aspirin, and analgesia. ( , 1973) |
| "Hence, peptic ulcer is the ulcer of both the stomach and the duodenum." | 3.01 | A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer. ( Ahmed, SI; Gogoi, HK; Kashyap, A; Maut, C; Roy, AJ, 2023) |
| "Periodontitis is the sixth most prevalent chronic disease globally and places significant burdens on societies and economies worldwide." | 3.01 | The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration. ( Fok, MR; Han, B; Lin, Y; Ren, J; Zhang, Y, 2023) |
| "Coronary thrombosis is known to provoke myocardial infarctions, but whether PWH have elevated thrombotic propensity is unknown." | 2.90 | Targeting thrombogenicity and inflammation in chronic HIV infection. ( Aberg, JA; Badimon, JJ; Cavanagh, K; Escolar, G; Heyison, A; O'Brien, MP; Okoroafor, I; Rodriguez, JC; Rodriguez-Caprio, G; Weinberg, A; Zafar, MU, 2019) |
| "Inflammation is linked to causes of infertility." | 2.84 | Preconception Low-Dose Aspirin Restores Diminished Pregnancy and Live Birth Rates in Women With Low-Grade Inflammation: A Secondary Analysis of a Randomized Trial. ( Galai, N; Mitchell, E; Mumford, SL; Perkins, NJ; Radin, RG; Schisterman, EF; Silver, RM; Sjaarda, LA; Stanford, JB; Wactawski-Wende, J; Wilcox, B, 2017) |
| "Aspirin has antiplatelet and immunomodulatory properties." | 2.78 | Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study. ( Aberg, JA; Berger, JS; Bhardwaj, N; Cavanagh, K; Gettenberg, G; Hu, L; Merolla, M; Montenont, E; Nardi, MA; O'Brien, M; Valdes, V, 2013) |
| " The administration of ASA before calving (even at a low dose) in combination with ω-3 FA did not exert any synergistic positive effect on inflammation and performance." | 2.78 | Effects of the precalving administration of omega-3 fatty acids alone or in combination with acetylsalicylic acid in periparturient dairy cows. ( Bertoni, G; Cappelli, FP; Grossi, P; Trevisi, E, 2013) |
| "Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is cardioprotective at lower doses (aspirin(low), 75 mg)." | 2.74 | Effects of low-dose aspirin on acute inflammatory responses in humans. ( Bellingan, G; Colville-Nash, P; de Souza, P; Gilroy, DW; Hobbs, A; Morris, T; Newson, J; Stables, M; Warner, T, 2009) |
| "In women with a history of recurrent miscarriage, the risk of miscarriage in a subsequent pregnancy is about 30% to 40%." | 2.74 | Use of heparin in women with early and late miscarriages with and without thrombophilia. ( Baumgarten, S; Dörner, T; Kadecki, O; Kiesewetter, H; Monien, S; Salama, A, 2009) |
| "Aspirin-treated men had increased levels of alpha-tocopherol than controls (P<0." | 2.71 | Cyclooxygenase-mediated prostaglandin F2alpha is decreased in an elderly population treated with low-dose aspirin. ( Basu, S; Helmersson, J; Larsson, A; Vessby, B, 2005) |
| "Two forms of mechanical hyperalgesia were examined: phasic mechanical stimuli by using a custom-made impact stimulator for the determination of individual pain thresholds, tonic mechanical stimuli were applied using a pinch-device." | 2.69 | Patterns of hyperalgesia in complex regional pain syndrome. ( Birklein, F; Handwerker, HO; Neundörfer, B; Riedl, B; Sieweke, N, 1999) |
| "Pretreatment with ibuprofen, a nonspecific COX inhibitor, attenuated the febrile and systemic response to LPS and inhibited prostanoid biosynthesis." | 2.69 | Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. ( Burke, A; FitzGerald, GA; Habib, A; Kapoor, S; Lawson, JA; Mardini, IA; McAdam, BF, 2000) |
| "Preeclampsia is considered a specific disease of pregnancy, but recent theories suggest that women suffering from the condition have greater propensity to develop atherosclerosis, heart disease, and stroke over the years." | 2.66 | Analyzing Preeclampsia as the Tip of the Iceberg Represented by Women with Long-Term Cardiovascular Disease, Atherosclerosis, and Inflammation. ( Diniz, AD; Diniz, ALD; Paes, MMBM, 2020) |
| " Hence, whether ASA might be a safe and reasonable therapeutic candidate to be tested in clinical trials involving adults with COVID-19 deserves further attention." | 2.66 | Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ? ( Bianconi, V; Fallarino, F; Pignatelli, P; Pirro, M; Sahebkar, A; Violi, F, 2020) |
| "Chronic obstructive pulmonary disease (COPD) is a heterogeneous multisystem disease, causing significant morbidity and mortality worldwide." | 2.66 | Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy. ( Ball, S; Mallah, H; Nugent, K; Parmar, K; Sekhon, J, 2020) |
| "Inflammation is a biological function which triggered after the mechanical tissue disruption or from the responses by the incidence of physical, chemical or biological negotiator in body." | 2.61 | Human disorders associated with inflammation and the evolving role of natural products to overcome. ( Kishore, N; Kumar, P; Shanker, K; Verma, AK, 2019) |
| "Neuropsychiatric disorders place a very high burden on the global health and economy." | 2.61 | Acetylsalicylic acid and its metabolite gentisic acid may act as adjunctive agents in the treatment of psychiatric disorders. ( Altinoz, MA; Ozpinar, A, 2019) |
| "Inflammation has been linked to several complications in pregnancy, including pregnancy loss." | 2.61 | The role of aspirin and inflammation on reproduction: the EAGeR trial ( Holland, TL; Kim, K; Levine, LD; Mumford, SL; Schisterman, EF; Sjaarda, LA, 2019) |
| "Angiogenic and non-angiogenic preeclampsia are identified by a sFlt-1PlGF≥85 and<85, respectively, with the risk of maternal and fetal complications at two weeks differing between the two." | 2.61 | [Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians]. ( Achiche, J; Ahriz Saksi, S; Bailleul, S; Boulanger, H; Drouin, D; Dupuis, E; Ekoukou, D; Lefèvre, G; Sault, C; Stawiarski, N, 2019) |
| "Aspirin also plays a role by its anti-inflammatory action and the stimulation of antitumor immunity." | 2.58 | [Aspirin and colorectal cancer]. ( Di Fiore, F; Grancher, A; Michel, P; Sefrioui, D, 2018) |
| "Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and progression." | 2.58 | Potential of anti-inflammatory agents for treatment of atherosclerosis. ( Chistiakov, DA; Grechko, AV; Melnichenko, AA; Myasoedova, VA; Orekhov, AN, 2018) |
| "Metformin and aspirin have been explored as two emerging cancer chemoprevention agents for different types of cancers, including pancreatic cancer." | 2.50 | Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. ( DiPaola, RS; Tan, XL; Yang, CS; Yue, W, 2014) |
| "Inflammation is a non-specific immune response to infection, irritation or other injury, the key features being redness, warmth, swelling and pain." | 2.49 | Immunoinflammatory responses in gastrointestinal tract injury and recovery. ( Alam, MM; Marella, A; Shaquiquzzaman, M; Verma, G, 2013) |
| "Inflammation has become a research hotspot in solid tumours and has been confirmed as a key factor in tumour development through the interactions of inflammatory mediators with gene expression, cell proliferation, and apoptosis." | 2.49 | Aspirin: a potential therapeutic approach in pancreatic cancer. ( Chen, C; Duan, W; Han, L; Li, P; Li, W; Ma, Q; Ma, Z; Shen, X; Xu, Q; Yu, S; Zhang, L, 2013) |
| "Aspirin and statins have been integral in the prevention of atherosclerotic disease." | 2.48 | Do aspirin and statins prevent severe sepsis? ( O'Neal, HR; Sanchez, MA; Thomas, CB, 2012) |
| "Women treated for preeclampsia also have an increased risk for cardiovascular and renal disease." | 2.48 | Preeclampsia 2012. ( Eiland, E; Faulkner, M; Nzerue, C, 2012) |
| "Inflammation is a formidable ally in the constant battle against infection, cancer and tissue injury." | 2.46 | Eicosanoids and the endogenous control of acute inflammatory resolution. ( Gilroy, DW, 2010) |
| "Rhinosinusitis is among the most common infectious complications of humoral immunodeficiency, which is not uncommon in patients with refractory CRS." | 2.46 | Rhinosinusitis and comorbidities. ( Brooks, EG; Ryan, MW, 2010) |
| "The pleural effusion was exudative and had a neutrophilic predominance." | 2.45 | Post-cardiac injury syndrome following transvenous pacemaker insertion: A case report and review of the literature. ( Cevik, C; Corona, R; Nugent, K; Schanzmeyer, E; Wilborn, T, 2009) |
| "Inflammation is a defensive response to injury and infection, but excessive or inappropriate inflammation contributes to a range of acute and chronic human diseases." | 2.45 | Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. ( Arita, M; Seki, H; Tani, Y, 2009) |
| "The resolution of inflammation is an active process controlled by endogenous mediators with selective actions on neutrophils and monocytes." | 2.45 | Lipoxins: resolutionary road. ( Godson, C; Maderna, P, 2009) |
| "Aspirin was used to induce damage in the morning, while XJZD was applied as an intervention in the afternoon." | 2.44 | Mechanism of Xiaojianzhong decoction in alleviating aspirin-induced gastric mucosal injury revealed by transcriptomics and metabolomics. ( Bao, SC; Chen, J; Chen, T; Hu, X; Li, JT; Liang, Y; Wei, HL; Yan, SG; Zhang, JX; Zhou, XY, 2024) |
| "As well as initiating thrombus formation at the site of a ruptured atherosclerotic plaque, platelets play a key role in vascular inflammation, through release of their own pro-inflammatory mediators and interactions with other relevant cell types (endothelial cells, leukocytes, and smooth muscle cells)." | 2.44 | Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease. ( Badimon, JJ; Bhatt, DL; Herbert, JM; Lüscher, TF; Steinhubl, SR, 2007) |
| "Aspirin has always remained an enigmatic drug." | 2.43 | New insights into the anti-inflammatory actions of aspirin-induction of nitric oxide through the generation of epi-lipoxins. ( Gilroy, DW, 2005) |
| "Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival." | 2.43 | NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review). ( Rigas, B; Zhang, Z, 2006) |
| "Aspirin treatment impacts biosynthesis of these compounds and a related series by triggering endogenous formation of the 17R-D series Resolvins and docosatrienes." | 2.42 | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. ( Arita, M; Gotlinger, K; Hong, S; Serhan, CN, 2004) |
| "Aspirin treatment initiates a related epimeric series by triggering endogenous formation of the 17R-D series resolvins and docosatrienes." | 2.42 | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. ( Arita, M; Gotlinger, K; Hong, S; Serhan, CN, 2004) |
| "Aspirin is known to inhibit vascular smooth muscle cell proliferation and to produce an endothelial stabilizing effect." | 2.41 | Nonplatelet-mediated effects of aspirin. ( Aude, YW; Mehta, JL, 2002) |
| "Kawasaki syndrome was first described in 1967 in Japan." | 2.38 | [Kawasaki syndrome]. ( Odermatt, K; Schaad, UB; Stocker, FP; Weber, JW; Wedgwood, J, 1990) |
| "Aspirin-like drugs inhibit the biosynthesis of prostaglandins in all tissues and species so far studied." | 2.35 | The mode of action of aspirin and similar compounds. ( Vane, JR, 1976) |
| "Systematic inflammation has been reported to contribute to cancer progression through various mechanisms; however, the exact mechanism is still the subject of research." | 1.91 | Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration. ( Fukuda, K; Hirahashi, J; Kawakubo, H; Kitagawa, Y; Kobayashi, R; Matsuda, S; Matsui, K; Nakamura, R; Nishimura, E; Okubo, K; Takeuchi, M, 2023) |
| "Type 1 diabetes mellitus was established by intraperitoneal injection of streptozotocin (65 mg/kg)." | 1.91 | Long-term aspirin administration suppresses inflammation in diabetic cystopathy. ( Du, H; Li, N; Liu, J; Qin, Y; Xu, F; Xu, Y; Zhang, J, 2023) |
| " The collection days (CD) were the second and seventh days after stable aspirin dosing and then a convalescent time point 2-9 months later." | 1.72 | Urinary 11-dehydrothromboxane B2 aspirin efficacy testing is sensitive to perioperative inflammation in pediatric solid-organ transplant patients. ( Boucher, AA; Francisco, BJ; Luchtman-Jones, L; Martin, J; Martin, M; Nathan, JD; Pfeiffer, A; Shova, A; Tiao, GM, 2022) |
| "Inflammation is linked with carcinogenesis in many types of cancer including colorectal cancer (CRC)." | 1.72 | Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer. ( Austin-Williams, S; Colas, RA; Dalli, J; De Matteis, R; Flak, MB; Gonzalez-Nunez, M; Palmas, F, 2022) |
| "Inflammation-driven scarring is a major contributor to surgical failure after subconjunctival bleb forming glaucoma surgery." | 1.72 | Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery. ( Armstrong, JJ; Hutnik, CML; Liu, H; Vinokurtseva, A, 2022) |
| "In LPS-treated mice, the PECAM-1/thrombus ratio decreased as the dose of ASA increased in both thrombosis models, but the direction of change in the thrombus area was inconsistent." | 1.62 | Utility of Platelet Endothelial Cell Adhesion Molecule 1 in the Platelet Activity Assessment in Mouse and Human Blood. ( Chabielska, E; Gromotowicz-Poplawska, A; Marcinczyk, N; Misztal, T; Radziwon, P; Rusak, T; Zebrowska, A, 2021) |
| "Aspirin is known to cause mucosal injury leading to increased gut permeability and tight junction damage and can be used as a model to study leaky gut in cattle." | 1.62 | Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle. ( Briggs, NG; Godoi, LA; Schoonmaker, JP; Silva, BC, 2021) |
| " Here, we confirmed the protective effect and mechanism of XST combined with DAPT (XST+ASA+CLP) on cerebral ischemia/reperfusion injury, exploring their better pharmacological action for clinical patients." | 1.62 | Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway. ( Dong, DX; Meng, XB; Qu, MW; Sun, GB; Sun, XB; Zhao, LY; Zhu, T, 2021) |
| "The degree of neovascularization, thrombus, calcification, inflammatory infiltrates, and fibrosis were analyzed histopathologically by hematoxylin and eosin staining." | 1.62 | Anti-thrombotic and anti-inflammatory activity of sulodexide compared to aspirin in the rat model. ( Jo, WM; Kim, JW; Kim, TS; Sohn, SH; Yoo, SM, 2021) |
| " On-demand, local delivery of anti-inflammatory drugs to target tissues provides an approach for more effective drug dosing while reducing the adverse effects of systemic drug delivery." | 1.56 | Adaptive in vivo device for theranostics of inflammation: Real-time monitoring of interferon-γ and aspirin. ( Cao, C; Chen, X; Jin, R; Liu, G; Liu, GJ; Liu, Z; Ni, S; Wei, H; Young, HA, 2020) |
| "Aspirin is a non-steroidal anti-inflammatory drug used to relieve both inflammatory symptoms and pain." | 1.56 | Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway. ( Duan, L; Jia, Y; Liu, Y; Lu, Y; Nong, L; Tan, A; Zhao, J, 2020) |
| "Neonatal ischemic stroke has a higher incidence than childhood stroke." | 1.56 | Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model. ( Choi, SG; Kang, JW; Kim, DW; Kim, SK; Shin, HJ; Song, HJ; Yi, YY, 2020) |
| "Aspirin treatment modified metabolites involved in suppressing lipogenesis, oxidative stress, and neoplastic formation." | 1.56 | Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth. ( Chiu, HH; Hsieh, CC; Kuo, CH; Wang, CH, 2020) |
| "Aspirin tended to increase jejunal CLDN-1 mRNA expression (P = 0." | 1.56 | Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle. ( Brennan, KM; Briggs, NG; Funnell, BJ; Nicholls, GT; Schoonmaker, JP, 2020) |
| "The widely recognized anti-cancer potential of aspirin has created a broad interest to explore the clinical benefits of aspirin in cancer therapy." | 1.56 | Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner. ( Du, R; Luo, N; Shen, W; Xiang, R; Zhang, X, 2020) |
| "Gallbladder stones (cholecystolithiasis) are the main risk factor for gallbladder cancer (GBC), a lethal biliary malignancy with poor survival rates worldwide." | 1.56 | Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia. ( Arrese, M; Bizama, C; Espinoza, JA; Ferreccio, C; García, P; Gómez, N; González, X; Guevara, F; Kalergis, AM; Lobos-González, L; Miquel, JF; Muñoz-Durango, N; Roa, JC; Rosa, L; Saavedra, N; Villegas, J; Wichmann, IA, 2020) |
| "Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa." | 1.51 | Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. ( Abd El-Ghffar, EA; Mahmoud, YI, 2019) |
| "Inflammation is closely related to neoplastic development and the release of inflammatory cytokines and chemokines represents a crucial event in this relationship." | 1.51 | Nonsteroidal Anti-inflammatory Drugs Modulate Gene Expression of Inflammatory Mediators in Oral Squamous Cell Carcinoma. ( Antunes, DM; Corrêa, L; DE Oliveira, APL; Duarte, CME; Fernandes, KPS; Guimarães, DM; Miguita, L; Nunes, FD; Rodrigues, MFSD, 2019) |
| "extract is traditionally used for the treatment of inflammation, bronchopneumonia, feverish pains, and breast cancer." | 1.48 | The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties. ( Alolga, RN; Hanson, C; Linus, LO; Liu, Q; Lu, YT; Njokuocha, RC; Qi, LW; Shi, N; Wang, SL, 2018) |
| "Acute inflammation of the vasculature, genetic susceptibility and immunopathogenesis based on a transmittable and infectious origin, are the pathologic events involved in the early inflammatory etiology and progression of this disease." | 1.48 | Melatonin: A hypothesis for Kawasaki disease treatment. ( Gil-Martín, E; López-Muñoz, F; Patiño, P; Ramos, E; Reiter, RJ; Romero, A, 2018) |
| "Chronic inflammation was detected in intact uninjured old nerves, characterized by increased macrophage infiltration and raised levels of monocyte chemoattractant protein 1 (MCP1) and CC chemokine ligand 11 (CCL11)." | 1.48 | Inflammaging impairs peripheral nerve maintenance and regeneration. ( Akula, AK; Baader, SL; Bauer, R; Büttner, R; Carlstedt, A; Mindos, T; Morrison, H; Reuter, M; Riecken, LB; Schulz, A, 2018) |
| " Therefore, we investigated whether the more stable aspirin-triggered (AT) epimer, AT-RvD1, combined with reduced doses of DEX is effective in treating TNF-α-mediated disruption of polarized rat parotid gland (Par-C10) epithelial cell clusters." | 1.43 | AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. ( Baker, OJ; Easley, JT; Maruyama, CL; Wang, CS, 2016) |
| "Aspirin is a very common anti-inflammatory medication to relieve aches and pains." | 1.43 | Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation. ( Bu, W; Chang, B; Gu, Z; Li, C; Lin, C; Shen, Y; Sun, H; Xu, X; Yang, B; Zhang, K; Zhao, L; Zheng, C, 2016) |
| "Leukotriene B4 (LTB4) is a potent inflammatory mediator derived from arachidonic acid." | 1.42 | Two distinct leukotriene B4 receptors, BLT1 and BLT2. ( Yokomizo, T, 2015) |
| "CAPE-indomethacin hybrid was able to significantly attenuate the clinical grading and the PGE2 aqueous levels only at the highest dose (0." | 1.42 | Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation. ( Bucolo, C; Drago, F; Modica, MN; Pittalà, V; Romano, GL; Romeo, G; Salerno, L; Salomone, S; Siracusa, MA, 2015) |
| "Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-promoting inflammation." | 1.42 | Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity. ( Acton, SE; Böttcher, JP; Chakravarty, P; Girotti, MR; Marais, R; Quezada, SA; Reis e Sousa, C; Rogers, N; Sahai, E; Snelgrove, KJ; van der Veen, AG; Zelenay, S, 2015) |
| "Platin-A exhibited anticancer and anti-inflammatory properties which are better than a combination of cisplatin and aspirin." | 1.40 | The prodrug platin-A: simultaneous release of cisplatin and aspirin. ( Berding, TB; Choi, JH; Dhar, S; Marrache, S; Pathak, RK, 2014) |
| "Choline was described to potentiate the antinociceptive action of aspirin at small doses in several inflammatory pain models." | 1.40 | Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide. ( Pan, ZY; Wang, H, 2014) |
| "Rheumatoid arthritis is a chronic inflammatory disease characterized by overproduction of inflammatory mediators along with undermined oxidative defensive mechanisms." | 1.40 | Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. ( El-Azab, MF; El-Sayed, RM; Moustafa, YM, 2014) |
| "Resolution of acute inflammation is an active process locally controlled by a novel genus of specialized pro-resolving mediators (SPM) that orchestrate key resolution responses." | 1.40 | Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. ( Chiang, N; Colas, RA; Dalli, J; Serhan, CN; Shinohara, M, 2014) |
| "Chronic inflammation has been linked to cancers, and use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of several cancers." | 1.40 | Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers: NIH-AARP study. ( Chu, LW; Hollenbeck, AR; Hsing, AW; Koshiol, J; Meyer, TE; Park, Y; Shebl, FM, 2014) |
| "Inflammation has been proposed to modify platelet function." | 1.39 | Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. ( Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB, 2013) |
| "Cystitis was induced in female rats by a single CYP injection." | 1.39 | Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder. ( Augé, C; Chene, G; Coelho, AM; Corman, B; Desoubzdanne, D; Dubourdeau, M; Lluel, P; Palea, S; Vergnolle, N, 2013) |
| "Rats treated with aspirin showed intestinal barrier dysfunction; high contents of the specific antigen were absorbed into the lamina propria." | 1.39 | Oral antigens induce rheumatoid arthritis-like inflammation in a rat model. ( Chen, X; Hu, D; Huang, Z; Liu, X; Liu, Z; Su, H; Wu, D; Yang, PC; Zhang, H, 2013) |
| "Inflammation is postulated to link obesity and benign prostatic hyperplasia (BPH)." | 1.39 | Body mass index predicts failure of surgical management in benign prostatic hyperplasia. ( Dick, CP; Edwards, J; Halbert, GL; Horgan, PG; Orange, C; Qayyum, T; Underwood, MA; Walker, VC; Willder, JM, 2013) |
| "Aspirin has a beneficial role in prevention of cardiovascular and thromboembolic events." | 1.38 | High frequency of aspirin resistance in patients with nephrotic syndrome. ( Agbaht, K; Akoglu, H; Dede, F; Falay, MY; Odabas, AR; Ozet, G; Piskinpasa, S, 2012) |
| "Left ventricular thrombus (LVT) and rupture are important mechanical complications following myocardial infarction (MI) and are believed to be due to unrelated mechanisms." | 1.37 | Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction. ( Dart, AM; Du, XJ; Gao, XM; Head, GA; Kiriazis, H; Liu, Y; Lobo, A; Shan, L, 2011) |
| "Aspirin treatment led to the normalization of inflammation- and oxidative stress-related mRNA levels in treated MPS IIIA mouse brains." | 1.37 | Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment. ( Arfi, A; Bonnefont-Rousselot, D; Gandolphe, C; Richard, M; Scherman, D; Thérond, P, 2011) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 1.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "The inflammation is one of the initial parameter for most of the disorders occurring in the body." | 1.37 | Differential inhibitory potencies of alcoholic extract of different parts of Dryopteris chrysocoma on inflammation in mice and rats. ( Ahmad, M; Jahan, N; Mohammad, N; Rehman, AB; Ullah, O, 2011) |
| "Treatment of aspirin significantly prevented the progression of nephropathy and inhibited the augmented COX-2, NFkappaB (p65 levels), TNFalpha, and TGFbeta-smad expression." | 1.36 | Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy. ( Gaikwad, AB; Mulay, SR; Tikoo, K, 2010) |
| "Oral squamous cell carcinoma (OSCC) is a major health problem worldwide, and patients have a particularly poor 5-year survival rate." | 1.36 | Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. ( Du, Z; Fan, M; Gu, W; Jiao, Y; Kim, JG; Nosrat, CA; Pavicevic, Z; Pfeffer, LM; Rao, SK; Rosebush, M; Samant, S, 2010) |
| " Our study demonstrated that a combination of aspirin and gammaT, but not a combination of aspirin and alphaT, has some advantage over aspirin alone in terms of anti-inflammatory effects and attenuation of aspirin-induced adverse effects." | 1.35 | A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. ( Ames, BN; Jiang, Q; Moreland, M; Yin, X, 2009) |
| " One important example of this type of injury is acetaminophen-induced liver injury, in which the initial toxic injury is followed by innate immune activation." | 1.35 | Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. ( Flavell, RA; Imaeda, AB; Mahmood, S; Mehal, WZ; Mohamadnejad, M; Sohail, MA; Sutterwala, FS; Watanabe, A, 2009) |
| "A population-based study of 750 rectal cancer cases with interview and tumor DNA were compared to 1,205 population-based controls." | 1.35 | Tumor markers and rectal cancer: support for an inflammation-related pathway. ( Caan, BJ; Herrick, J; Samowitz, W; Slattery, ML; Wolff, RK, 2009) |
| "Aspirin has anti-inflammatory and antineoplastic activity." | 1.35 | Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils. ( Chan, AO; Chen, MH; Cho, CH; Gu, Q; Hu, PJ; Li, GQ; Liang, YJ; Lin, HL; Qiao, L; So, WH; Tatematsu, M; Tsukamoto, T; Wong, BC; Xia, HH; Yuen, MF, 2008) |
| " Increasing evidence suggests that an inflammatory reaction accompanies the pathological processes caused by Cyclooxygenase (COX) seen in many neurodegenerative disorders, including PD and according to the recent researches chronic use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) decreases the risk of PD in human." | 1.34 | Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease. ( Abid, KM; Ardestani, MS; Hemmati, A; Mehrab, H; Moghaddam, HF; Nazari, Z, 2007) |
| "Atherosclerosis is an inflammatory response of the arterial wall to 'injury', which is prominently driven by inflammatory factors." | 1.34 | Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model. ( Li, M; Ren, H; Zhang, Y; Zhu, X, 2007) |
| " The antinociceptive efficacies were evaluated using several dose-response curves and time courses." | 1.34 | Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. ( Déciga-Campos, M; González-Trujano, ME; Guevara-Fefer, P; López-Muñoz, FJ; Martínez, AL; Moreno, J; Peña, EI, 2007) |
| "This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level." | 1.34 | Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. ( Serhan, CN; Svensson, CI; Zattoni, M, 2007) |
| "Aspirin resistance was defined when epinephrine closure time <174 s." | 1.34 | Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease. ( de Lafuente, JP; Iriarte, JA; Lafita, M; Molinero, E; Monica, S; Narvaez, I; Saez, Y; Sagastagoitia, JD; Vacas, M, 2007) |
| "Treatment with aspirin (200 mg/kg, p." | 1.33 | Influence of protein malnutrition on induction and treatment of inflammation in mice. ( Bassiouny, K; Hamed, MR; Hassanein, NM; Talaat, RM, 2006) |
| "Acute inflammation was induced by subplantar injection of 0." | 1.33 | New xanthone derivatives as potent anti-inflammatory agents. ( Czarnecki, R; Czekaj, T; Librowski, T; Marona, H, 2005) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 1.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "Control of inflammation is crucial to prevent damage to the host during infection." | 1.33 | Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. ( Aliberti, J; Bafica, A; Dias, A; Esper, L; Johndrow, JE; Machado, FS; Serhan, CN, 2006) |
| "The occurrence of Kawasaki disease is unusual in adults." | 1.33 | Kawasaki-like syndrome possibly associated with immune reconstitution inflammatory syndrome in an HIV-positive patient. ( Crespo, A; Menezes, L; Velez, AP, 2006) |
| "Pretreatment with aspirin or bilirubin at low micromolar concentrations protected endothelial cells from hydrogen peroxide-mediated toxicity." | 1.32 | Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. ( Abate, A; Becker, JC; Dennery, PA; Grosser, N; Oberle, S; Pohle, T; Schröder, H; Seidman, DS; Vreman, HJ, 2003) |
| "This is the first study to show that type 2 diabetes in elderly men is related to COX-mediated inflammation, reflected by enhanced prostaglandin formation." | 1.32 | Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. ( Basu, S; Helmersson, J; Larsson, A; Vessby, B, 2004) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "Myocardial infarction (MI) and congestive heart failure (CHF) were induced in rats by ligating the left coronary artery." | 1.32 | Inhibition of COX pathway in experimental myocardial infarction. ( Giaid, A; Hu, F; Huynh, T; Robinson, R; Rodger, IW; Saito, T, 2004) |
| "Endothelial dysfunction, defined as a deficit in the bioavailability of nitric oxide (NO), occurs as sequelae of many vascular diseases; however, the utility of supplementing NO to obviate the extent of disease is understudied." | 1.31 | Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. ( Rudic, RD; Sessa, WC; Yu, J, 2002) |
| "Mechanical hyperalgesia was significantly reduced by the pre-treatment of 150 mg/kg, but not 50 mg/kg aspirin." | 1.31 | Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Pioglitazone was given to the rats by gastric intubation 1 h before the aspirin administration." | 1.31 | Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats. ( Matsuyama, K; Naito, Y; Takagi, T; Yoshida, N; Yoshikawa, T, 2001) |
| "Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals." | 1.31 | A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Because brain ischemia has recently been recognized to contribute to the pathogenesis of AD, we studied the effect of focal brain ischemia in 8- and 20-month-old mice overexpressing the 751-amino acid isoform of human APP." | 1.31 | Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. ( Bures, J; Goldsteins, G; Higgins, LS; Kauppinen, RA; Keinänen, R; Kettunen, MI; Koistinaho, J; Koistinaho, M; Liu, D; Ort, M; Salminen, A, 2002) |
| " Dose-response analyses employing the fever model demonstrated that potency of aspirin to reduce fever was increased 5 to 10-fold when the aspirin was intragastrically administered in the lipid-associated state." | 1.29 | Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems. ( Dial, EJ; Illich, PA; Lichtenberger, LM; Romero, JJ; Ulloa, C; Vanous, AL; Walters, ET, 1996) |
| "Aspirin-when tested-was less potent than fenflumizole and indomethacin." | 1.27 | Fenflumizole: interactions with the arachidonic acid cascade. ( Corell, T; Hasselmann, G; Splawinski, J; Wojtaszek, B, 1983) |
| "Salicylic acid may produce its analgesic action mainly via a central mechanism." | 1.27 | Two modes of analgesic action of aspirin, and the site of analgesic action of salicylic acid. ( Aihara, H; Higuchi, S; Otomo, S; Shioiri, Y; Tanaka, N, 1986) |
| "Neutrophils were seen in one atopic eczema patient, but were not observed in the remainder, nor in the skin of the aspirin-pretreated normal subjects." | 1.27 | The cellular inflammatory response in nicotinate skin reactions. ( English, JS; Greaves, MW; Louback, JB; MacDonald, DM; Winkelmann, RK, 1987) |
| "025-16 micrograms/paw) were followed by a bell-shaped dose-response curve for oedema." | 1.27 | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. ( Castro, HC; Cordeiro, RS; Lima, MC; Martins, MA; Neto, F; Silva, PM; Vargaftig, BB, 1987) |
| "Benzydamine is an anti-inflammatory drug with unique medical uses, namely the topical treatment of oro-pharyngeal and gynaecological conditions." | 1.27 | Benzydamine, an unique model of anti-inflammatory activity. ( Silvestrini, B, 1987) |
| " Dose-response experiments performed with 2 to 90 per cent (v/v) zymosan-activated plasma showed a direct correlation between the rate of neutrophil influx and the degree of vascular permeability in blood flow." | 1.26 | Vascular responses during acute neutrophilic inflammation. Their relationship to in vivo neutrophil emigration. ( Issekutz, AC, 1981) |
| "Indomethacin and ASA were also administered locally intradermally (id) into skin sites together with the E." | 1.26 | The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation. ( Bhimji, S; Issekutz, AC, 1982) |
| "It is mainly the secondary phase of adjuvant arthritis which cannot be inhibited by treatment with several proteins." | 1.26 | The modulation of inflammation by the acute phase reaction in adjuvant arthritis in rats. ( Bekemeier, H; Hirschelmann, R; Schade, R, 1981) |
| "Circular burns were inflicted on anaesthetized animals which were killed 30 min, 2 h or 4 h after burning." | 1.26 | On the enzymatic response to injury and its mediators. ( Nieminen, L; Raekallio, J, 1979) |
| "The aspirin-pretreated animals showed less inflammatory reaction after cryotherapy and significantly less protein in the aqueous humor than did the control animals (P less than ." | 1.26 | Experimental inhibition of prostaglandin-like inflammatory response after cryotherapy. ( Chavis, RM; Vygantas, A; Vygantas, CM, 1976) |
| " The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid." | 1.25 | Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 202 (26.13) | 18.7374 |
| 1990's | 51 (6.60) | 18.2507 |
| 2000's | 209 (27.04) | 29.6817 |
| 2010's | 214 (27.68) | 24.3611 |
| 2020's | 97 (12.55) | 2.80 |
| Authors | Studies |
|---|---|
| Clark, RL | 1 |
| Pessolano, AA | 1 |
| Shen, TY | 1 |
| Jacobus, DP | 1 |
| Jones, H | 1 |
| Lotti, VJ | 1 |
| Flataker, LM | 1 |
| Cohen, N | 1 |
| Banner, BL | 1 |
| Lopresti, RJ | 1 |
| Muchowski, JM | 1 |
| Galeazzi, E | 1 |
| Greenhouse, R | 1 |
| Guzmán, A | 1 |
| Peréz, V | 1 |
| Ackerman, N | 1 |
| Ballaron, SA | 1 |
| Rovito, JR | 1 |
| Tomolonis, AJ | 1 |
| Young, JM | 1 |
| Voilley, N | 1 |
| de Weille, J | 1 |
| Mamet, J | 1 |
| Lazdunski, M | 1 |
| Franklin, PX | 1 |
| Pillai, AD | 1 |
| Rathod, PD | 1 |
| Yerande, S | 1 |
| Nivsarkar, M | 1 |
| Padh, H | 1 |
| Vasu, KK | 1 |
| Sudarsanam, V | 1 |
| Sharma, M | 1 |
| Ray, SM | 1 |
| Bi, L | 1 |
| Zhao, M | 3 |
| Gu, K | 1 |
| Wang, C | 1 |
| Ju, J | 1 |
| Peng, S | 2 |
| Abdel-Hafez, ShH | 1 |
| Sadanandam, YS | 1 |
| Shetty, MM | 1 |
| Rao, AB | 1 |
| Rambabu, Y | 1 |
| Abdellatif, KR | 3 |
| Chowdhury, MA | 3 |
| Dong, Y | 4 |
| Knaus, EE | 3 |
| Rahman, M | 1 |
| Das, D | 1 |
| Suresh, MR | 1 |
| Gökçe, M | 1 |
| Utku, S | 1 |
| Küpeli, E | 2 |
| Khan, KM | 1 |
| Ambreen, N | 1 |
| Mughal, UR | 1 |
| Jalil, S | 1 |
| Perveen, S | 1 |
| Choudhary, MI | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Riça, IG | 1 |
| Netto, CD | 1 |
| Rennó, MN | 1 |
| Abreu, PA | 1 |
| Costa, PRR | 1 |
| da Silva, AJM | 1 |
| Cavalcante, MCM | 1 |
| Kim, SO | 1 |
| Han, Y | 1 |
| Ahn, S | 1 |
| An, S | 1 |
| Shin, JC | 1 |
| Choi, H | 2 |
| Kim, HJ | 1 |
| Park, NH | 1 |
| Kim, YJ | 2 |
| Jin, SH | 1 |
| Rho, HS | 1 |
| Noh, M | 1 |
| Galijasevic, S | 1 |
| Ali, EMH | 1 |
| Abdel-Maksoud, MS | 1 |
| Oh, CH | 1 |
| Kishore, N | 1 |
| Kumar, P | 1 |
| Shanker, K | 1 |
| Verma, AK | 1 |
| Mullol, J | 3 |
| Boyce, J | 1 |
| Dahlén, SE | 2 |
| Dahlén, B | 2 |
| Picado, C | 3 |
| Bobolea, I | 1 |
| Marcinczyk, N | 1 |
| Misztal, T | 1 |
| Gromotowicz-Poplawska, A | 1 |
| Zebrowska, A | 1 |
| Rusak, T | 1 |
| Radziwon, P | 1 |
| Chabielska, E | 1 |
| Vogelsang, A | 1 |
| Eichler, S | 1 |
| Huntemann, N | 1 |
| Masanneck, L | 1 |
| Böhnlein, H | 1 |
| Schüngel, L | 1 |
| Willison, A | 1 |
| Loser, K | 1 |
| Nieswandt, B | 1 |
| Kehrel, BE | 1 |
| Zarbock, A | 1 |
| Göbel, K | 1 |
| Meuth, SG | 1 |
| Boucher, AA | 1 |
| Francisco, BJ | 1 |
| Pfeiffer, A | 1 |
| Martin, M | 1 |
| Martin, J | 1 |
| Shova, A | 1 |
| Nathan, JD | 1 |
| Tiao, GM | 1 |
| Luchtman-Jones, L | 1 |
| Ghosh, S | 1 |
| Briggs, NG | 2 |
| Silva, BC | 1 |
| Godoi, LA | 1 |
| Schoonmaker, JP | 2 |
| Silva, JBNF | 1 |
| Calcia, TBB | 1 |
| Silva, CP | 1 |
| Guilherme, RF | 1 |
| Almeida-Souza, F | 1 |
| Lemos, FS | 1 |
| Calabrese, KS | 1 |
| Caruso-Neves, C | 1 |
| Neves, JS | 1 |
| Benjamim, CF | 1 |
| Formiga, F | 1 |
| Rubio-Rivas, M | 1 |
| Mora-Luján, JM | 1 |
| Escudero, SC | 1 |
| Martinez, RFM | 1 |
| Mendez-Bailón, M | 1 |
| Campo, PD | 1 |
| Pérez, AR | 1 |
| García-Sánchez, FJ | 1 |
| Alcalá-Pedrajas, JN | 1 |
| Hernández, SA | 1 |
| Milian, AH | 1 |
| Díez, AL | 1 |
| Sánchez, RG | 1 |
| Boixeda, R | 1 |
| Vicente, J | 1 |
| Cortes, B | 1 |
| Pérez, CM | 1 |
| Espartero, MEG | 1 |
| Castro, JL | 1 |
| Suárez, SR | 1 |
| Varona, JF | 1 |
| Gomez-Huelgas, R | 1 |
| Ramos-Rincón, JM | 1 |
| Sairam, S | 1 |
| Sureen, A | 1 |
| Gutierrez, J | 1 |
| Dang, TQ | 1 |
| Mishra, K | 1 |
| De Matteis, R | 1 |
| Flak, MB | 1 |
| Gonzalez-Nunez, M | 1 |
| Austin-Williams, S | 1 |
| Palmas, F | 1 |
| Colas, RA | 5 |
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| Paolini, JP | 1 |
| Lendvay, LJ | 1 |
| Fleming, JS | 1 |
| Bierwagen, ME | 1 |
| Pircio, AW | 2 |
| Pindell, MH | 1 |
| Funderburk, WH | 1 |
| Foxwell, MH | 1 |
| Johnson, DN | 1 |
| Ward, JW | 1 |
| Atkinson, DC | 1 |
| Boura, AL | 1 |
| Hicks, R | 1 |
| Henrard, JC | 1 |
| van Arman, CG | 1 |
| Thomas, RH | 1 |
| Asai, H | 1 |
| Abbondati, G | 1 |
| Cornelli, U | 1 |
| Preti, M | 1 |
| Trimarchi, F | 1 |
| Dick, WC | 1 |
| Nuki, G | 1 |
| Whaley, K | 1 |
| Deodhar, S | 1 |
| Nakanishi, M | 1 |
| Imamura, H | 1 |
| Ikegami, K | 1 |
| Goto, K | 1 |
| Nakamura, H | 1 |
| Kadokawa, T | 1 |
| Nakatsuji, K | 1 |
| Sancilio, LF | 1 |
| Kumagai, A | 1 |
| Homma, M | 1 |
| Groskinsky, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficiency of Flurbiprofen 2.5% in Comparison to 98% Aloe Vera Gel as an Adjunctive Therapy to Scaling and Root Planning in the Initial Treatment of Stage III Chronic Periodontitis in Smoking Patients[NCT06041178] | Phase 4 | 60 participants (Actual) | Interventional | 2022-09-30 | Completed | ||
| Synergistic Influence of Rivaroxaban on Inflammation and Coagulation Biomarkers in Patients With CAD and PAD on Aspirin Therapy[NCT04059679] | Phase 4 | 30 participants (Anticipated) | Interventional | 2020-01-30 | Recruiting | ||
| Multicenter Randomized, Double-blind, Placebo-controlled, Clinical Trial of Acetylsalicylic Acid in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients (Asperum)[NCT04808895] | Phase 3 | 204 participants (Anticipated) | Interventional | 2021-04-01 | Not yet recruiting | ||
| The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363] | 1,228 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268] | Phase 4 | 72 participants (Actual) | Interventional | 2019-04-24 | Completed | ||
| Characterisation of a Novel Regimen of Very Low-dose Aspirin Combined With Rivaroxaban in Patients With Chronic Coronary Syndromes: WILL lOWer Dose Aspirin be Better With Rivaroxaban in Patients With Chronic Coronary Syndromes?[NCT04990791] | Phase 4 | 48 participants (Anticipated) | Interventional | 2021-08-26 | Recruiting | ||
| ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA[NCT04899206] | 120 participants (Anticipated) | Observational [Patient Registry] | 2021-04-12 | Active, not recruiting | |||
| [NCT01075867] | 2,498 participants (Actual) | Observational | 2010-04-30 | Completed | |||
| Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting[NCT01276691] | Phase 4 | 24 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Targeting Platelets in Chronic HIV Infection[NCT02578706] | Phase 2 | 27 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Aspirin as a Promising Agent to Attenuate Inflammation in the Wall of Human Cerebral Aneurysms[NCT01710072] | Phase 1 | 11 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Specialized Proresolving Mediators Evaluation in Pneumocystis Pneumonia Human Infection : Pilot Study.[NCT03606252] | 66 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
| Influence of an Omega-3 SPM Supplement on Quality of Life[NCT02683850] | Early Phase 1 | 44 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury[NCT01659307] | Phase 2 | 33 participants (Anticipated) | Interventional | 2012-09-30 | Completed | ||
| Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction)[NCT02428374] | Phase 4 | 300 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases[NCT01867281] | Phase 4 | 32 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Omega EVAR: Use of Fish Oil to Reduce Inflammation During Endovascular Abdominal Aortic Repair.[NCT03208920] | 2 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| THE OMEGA-SPM-DOSE and OMEGA-SPM-PAD: Specialized Pro-Resolving Mediators in Patients With Peripheral Artery Disease[NCT02719665] | 30 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| Arterial Imaging of Inflammation and Resolution After Endovascular Surgery[NCT03590769] | Phase 1 | 9 participants (Actual) | Interventional | 2017-06-01 | Completed | ||
| Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo[NCT02820441] | Phase 4 | 2 participants (Actual) | Interventional | 2016-05-31 | Terminated | ||
| [NCT02854397] | 31 participants (Actual) | Observational | 2016-02-15 | Terminated (stopped due to Recruitment difficulties) | |||
| Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial[NCT03262961] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2016-09-15 | Recruiting | ||
| Diagnostic Value of microRNA 210 In Preeclampsia[NCT03193554] | 80 participants (Anticipated) | Observational [Patient Registry] | 2019-01-01 | Recruiting | |||
| Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial.[NCT03368430] | Phase 4 | 74 participants (Actual) | Interventional | 2016-07-04 | Completed | ||
| A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation in High Risk Primary Prevention (Patients With Metabolic Syndrome)[NCT00272311] | Phase 4 | 70 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation & Endothelial Function in Secondary Prevention (Pts w/Chronic Stable Coronary Disease)[NCT00272337] | Phase 4 | 37 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW-ACS)[NCT02741817] | Phase 4 | 20 participants (Actual) | Interventional | 2016-06-26 | Completed | ||
| Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
| Randomized Controlled Trial of Marine Lipid Fraction PCSO-524™ on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Asthma[NCT01504646] | 20 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Effects of Early Atorvastatin Treatment During the Acute Phase of Stroke on Immunoinflammatory Markers and Outcome in Patients With Acute Ischemic Stroke Classified as LAAS According TOAST Classification[NCT02225834] | Phase 4 | 50 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [NCT00000500] | Phase 3 | 0 participants | Interventional | 1981-09-30 | Completed | ||
| Gender-Specific Effects of Physiologic GH Administration on Cardiovascular Risk Factors in Women With Growth Hormone Deficiency[NCT00136032] | 63 participants (Actual) | Interventional | 2002-01-31 | Completed | |||
| A Randomized Trial of Plaque Identifying Toothpaste on Reduction of Plaque and Inflammation[NCT02666508] | 61 participants (Actual) | Interventional | 2015-09-01 | Completed | |||
| Correlation Between Oral Health and Systemic Inflammation (COHESION)[NCT03641989] | 112 participants (Actual) | Interventional | 2018-09-17 | Completed | |||
| Randomised Controlled Trial On The Effects Of Parenteral Fish Oil Emulsion In Patients With Severe Acute Pancreatitis[NCT01745861] | Phase 2 | 44 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Renal and Cardiovascular Impairment in WTC Responders: Implications for Diagnosis and Treatment[NCT02246101] | 406 participants (Actual) | Observational | 2014-07-31 | Completed | |||
| A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Effect of Dietary Nitrate on a Model of Vascular Dysfunction in Healthy Volunteers[NCT02715635] | Phase 1 | 78 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery
| Intervention | participants (Number) |
|---|---|
| Aspirin | 7 |
| Placebo | 5 |
(NCT00467363)
Timeframe: 8-weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 374 |
| Placebo | 346 |
Implantation failures (NCT00467363)
Timeframe: 8 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 28 |
| Placebo | 27 |
(NCT00467363)
Timeframe: within 6 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 3 |
| Placebo | 3 |
(NCT00467363)
Timeframe: until 40 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 4 |
| Placebo | 6 |
(NCT00467363)
Timeframe: within 8-weeks of gestation
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 394 |
| Placebo | 363 |
Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery
| Intervention | livebirths (Number) |
|---|---|
| Aspirin | 309 |
| Placebo | 286 |
(NCT00467363)
Timeframe: 8 weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 0 |
| Placebo | 0 |
(NCT00467363)
Timeframe: until delivery
| Intervention | participants (Number) |
|---|---|
| Aspirin | 32 |
| Placebo | 30 |
Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks
| Intervention | pregnancy (Number) |
|---|---|
| Aspirin | 56 |
| Placebo | 53 |
(NCT00467363)
Timeframe: until delivery
| Intervention | infants (Number) |
|---|---|
| Aspirin | 22 |
| Placebo | 31 |
birthweight (NCT00467363)
Timeframe: until delivery
| Intervention | grams (Mean) |
|---|---|
| Aspirin | 3327 |
| Placebo | 3315 |
(NCT00467363)
Timeframe: 40 weeks
| Intervention | participants (Number) |
|---|---|
| Aspirin | 2 |
| Placebo | 2 |
Alpha angle is measured using thromboelastography, measured by a tangent to the clotting curve through the 2mm point (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | degree (Mean) |
|---|---|
| Aspirin and Placebo | 0.00 |
| Clopidogrel and Placebo | -0.60 |
| Placebo Only | -0.50 |
The classical monocyte is characterized by high level expression of the CD14 cell surface receptor (CD14++ CD16- monocyte) (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | 10^3 cells/µl (Mean) |
|---|---|
| Aspirin and Placebo | -0.09 |
| Clopidogrel and Placebo | -0.12 |
| Placebo Only | -0.04 |
Clot formation time is measured using thromboelastography. time from 2 to 20 mm amplitude in seconds. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | seconds (Mean) |
|---|---|
| Aspirin and Placebo | -1.00 |
| Clopidogrel and Placebo | 2.00 |
| Placebo Only | 1.63 |
Clot formation kinetics, or coagulation time, is measured using thromboelastography. time to 2mm amplitude in seconds. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | seconds (Mean) |
|---|---|
| Aspirin and Placebo | 3.00 |
| Clopidogrel and Placebo | 1.00 |
| Placebo Only | -13.13 |
D-Dimer level looks at coagulation of blood. D-dimers are not normally present in blood except when coagulation has occurred. (NCT02578706)
Timeframe: Baseline and 24 weeks
| Intervention | mcg/L (Mean) |
|---|---|
| Aspirin and Placebo | -295.99 |
| Clopidogrel and Placebo | 151.96 |
| Placebo Only | 1109.38 |
Interleukin 6 gene encodes a cytokine that functions in inflammation and implicated in a variety of inflammatory-associated disease states. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | pg/mL (Mean) |
|---|---|
| Aspirin and Placebo | -0.36 |
| Clopidogrel and Placebo | 0.02 |
| Placebo Only | 0.85 |
The intermediate monocyte with high level expression of CD14 and low level expression of CD16 (CD14++CD16+ monocytes). (NCT02578706)
Timeframe: Baseline and 24 weeks
| Intervention | 10^3 cells/µl (Mean) |
|---|---|
| Aspirin and Placebo | 0.02 |
| Clopidogrel and Placebo | 0.06 |
| Placebo Only | 0.04 |
Maximum Clot Firmness (MCF) is measured using thromboelastography. maximum ampliture in mm (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | mm (Mean) |
|---|---|
| Aspirin and Placebo | 1.38 |
| Clopidogrel and Placebo | 1.20 |
| Placebo Only | 0.38 |
Soluble CD163 is a specific macrophage activation marker, associated with morphological disease grade. A high sCD163 indicates more disease. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | 10^3 cells/µl (Mean) |
|---|---|
| Aspirin and Placebo | 26.88 |
| Clopidogrel and Placebo | 15.8 |
| Placebo Only | -63.38 |
Change in % platelet monocyte aggregates from baseline to week 24 (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | % platelet monocyte aggregates (Mean) |
|---|---|
| Aspirin and Placebo | 10.55 |
| Clopidogrel and Placebo | 3.88 |
| Placebo Only | 8.96 |
The non-classical monocyte shows low level expression of CD14 and additional co-expression of the CD16 receptor (CD14+CD16++ monocyte).[ (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | 10^3 cells/µl (Mean) |
|---|---|
| Aspirin and Placebo | 0.002 |
| Clopidogrel and Placebo | 0.03 |
| Placebo Only | -0.03 |
Change in % platelet aggregation in response to stimulation by Adenosine Diphosphate (ADP) from baseline to week 24 (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | % platelet aggregation (Mean) |
|---|---|
| Aspirin and Placebo | -7.25 |
| Clopidogrel and Placebo | -32.40 |
| Placebo Only | -6.50 |
Change in % platelet aggregation in response to stimulation by arachidonic acid 1500µM from baseline to week 24 (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | % platelet aggregation (Mean) |
|---|---|
| Aspirin and Placebo | -53.33 |
| Clopidogrel and Placebo | -31.00 |
| Placebo Only | -13.25 |
Change in % platelet aggregation in response to stimulation by Collagen 2µg/mL from baseline to week 24 (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | % platelet aggregation (Mean) |
|---|---|
| Aspirin and Placebo | -40.37 |
| Clopidogrel and Placebo | -9.60 |
| Placebo Only | 8.62 |
Change in % platelet aggregation in response to stimulation by light transmission aggregometry as measured by epinephrine 5µM from baseline to week 24 (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | % platelet aggregation (Mean) |
|---|---|
| Aspirin and Placebo | -35.25 |
| Clopidogrel and Placebo | -21.40 |
| Placebo Only | -10.63 |
Soluble CD14 (sCD14) levels in blood. sCD14 is a nonspecific maker of monocyte activation. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | pg/mL (Mean) |
|---|---|
| Aspirin and Placebo | 35.75 |
| Clopidogrel and Placebo | -251.40 |
| Placebo Only | -101.75 |
Soluble CD40-ligand levels (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | pg/mL (Mean) |
|---|---|
| Aspirin and Placebo | -28.05 |
| Clopidogrel and Placebo | -25.68 |
| Placebo Only | 13.65 |
Change in spontaneous % platelet from baseline to week 24. Spontaneous platelet aggregation? (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | % platelet (Mean) |
|---|---|
| Aspirin and Placebo | -0.75 |
| Clopidogrel and Placebo | -0.60 |
| Placebo Only | -0.88 |
Soluble tumor necrosis factor receptor (sTNFR) serum concentration (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | pg/ml (Mean) |
|---|---|
| Aspirin and Placebo | 137.77 |
| Clopidogrel and Placebo | 59.46 |
| Placebo Only | 19.78 |
Soluble tumor necrosis factor receptor (sTNFR) serum concentration (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | pg/ml (Mean) |
|---|---|
| Aspirin and Placebo | 283.13 |
| Clopidogrel and Placebo | 347.00 |
| Placebo Only | 4.25 |
substudy - Change in thrombus formation by Badimon chamber (high shear) from baseline to 24 weeks. Thrombus formation on a blood vessel measured by immunohistochemistry staining of tissue cross sections. The high shear chambers (inner lumen diameter 0.1 mm, Reynolds number 60, shear rate 1690 s- 1) mimic the rheologic conditions of a moderately stenosed coronary artery. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | μ(2)/mm (Mean) |
|---|---|
| Aspirin and Placebo | -3052.20 |
| Clopidogrel and Placebo | -2798.80 |
| Placebo Only | -753.00 |
substudy - Change in thrombus formation by Badimon chamber (low shear) from baseline to 24 weeks. Thrombus formation on a blood vessel measured by immunohistochemistry staining of tissue cross sections. μ(2)/mm is the area of thrombus. The low shear chamber (inner lumen diameter 0.2 mm, Reynolds number 30, shear rate 500 s- 1) simulates flow conditions of a normal coronary artery. (NCT02578706)
Timeframe: baseline and 24 weeks
| Intervention | μ(2)/mm (Mean) |
|---|---|
| Aspirin and Placebo | -1036 |
| Clopidogrel and Placebo | -899.20 |
| Placebo Only | -203.75 |
Safety as measured by a Summary of the number of subjects with at least one grade 3 or higher sign/symptom or laboratory abnormality. A grade 3 sign/symptom was defined as medically significant but not immediately life threatening. (NCT02578706)
Timeframe: 24 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Aspirin and Placebo | 0 |
| Clopidogrel and Placebo | 1 |
| Placebo Only | 0 |
Changes in Heme oxygenase (HO-1) a downstream target of nitric oxide (NO) formation. (NCT00272311)
Timeframe: Baseline to 3 Months (90-97 days)
| Intervention | ng/mL (Mean) |
|---|---|
| Arm 1 of 5 Randomized Treatment Arms | 27.6 |
| Arm 2 of 5 Randomized Treatment Arms | 27.0 |
| Arm 3 of 5 Randomized Treatment Arms | 31.4 |
| Arm 4 of 5 Randomized Treatment Arms | 25.7 |
| Arm 5 of 5 Randomized Treatment Arms | 28.3 |
Heme oxygenase a downstream target of nitric oxide formation (NCT00272337)
Timeframe: Baseline to 3 Months (90-97 days)
| Intervention | ng/mL (Mean) |
|---|---|
| 1 of 5 Randomized Treatment Arms | 10.0 |
| 2 of 5 Randomized Treatment Arms | 11.2 |
| 3 of 5 Randomized Treatment Arms | 10.0 |
| 4 of 5 Randomized Treatment Arms | 11.0 |
| 5 of 5 Randomized Treatment Arms | 9.6 |
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 189 |
| Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1078 |
| Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 78 |
| Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 303 |
| Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 134 |
| Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 141 |
| Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 42 |
| Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 352 |
| Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 264 |
| Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 668 |
| Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1506 |
| Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 214 |
| Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 26 |
| Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 54 |
| Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 9 |
| Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 23 |
| Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 290 |
| Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 8 |
| Placebo Arm | 21 |
"Measure description mg/L refers to the change in hs-CRP per mg/L from the baseline to the follow-up visit. The follow-up visit occurred between 30 and 60 days post baseline." (NCT02666508)
Timeframe: Baseline to 30 - 60 days post baseline
| Intervention | log(mg/L) (Geometric Mean) |
|---|---|
| Plaque Identifying Toothpaste | 0.04 |
| Non-plaque Identifying Toothpaste | 0.22 |
"Measure description mg/L refers to the change in hs-CRP per mg/L from the baseline to the follow-up visit. The follow-up visit occurred between 30 and 60 days post baseline. -PSS analysis" (NCT02666508)
Timeframe: Baseline to 30-60 days post
| Intervention | log(mg/L) (Geometric Mean) |
|---|---|
| Plaque Identifying Toothpaste | -0.40 |
| Non-plaque Identifying Toothpaste | 0.14 |
"Measure description percentage refers to the change in plaque percentage from the baseline to the follow-up visit. The follow-up visit occurred between 30 and 60 days post baseline." (NCT02666508)
Timeframe: Baseline to 30 - 60 days post baseline
| Intervention | log(percentage) (Geometric Mean) |
|---|---|
| Plaque Identifying Toothpaste | -1.05 |
| Non-plaque Identifying Toothpaste | -0.03 |
"Measure description percentage refers to the change in plaque percentage from the baseline to the follow-up visit. The follow-up visit occurred between 30 and 60 days post baseline for the Pre-Specified Subgroup (PSS)." (NCT02666508)
Timeframe: Baseline to 30-60 days post
| Intervention | log(percentage) (Geometric Mean) |
|---|---|
| Plaque Identifying Toothpaste | -1.05 |
| Non-plaque Identifying Toothpaste | -0.10 |
154 reviews available for aspirin and Innate Inflammatory Response
| Article | Year |
|---|---|
The development of myeloperoxidase inhibitors.
Topics: Animals; Enzyme Inhibitors; Humans; Inflammation; Molecular Structure; Monocytes; Neutrophils; Perox | 2019 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemistry, Ph | 2019 |
Human disorders associated with inflammation and the evolving role of natural products to overcome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Products; Cardiovascular | 2019 |
Metabolomic Studies for Metabolic Alterations Induced by Non-Steroidal Anti-Inflammatory Drugs: Mini Review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Humans; Ibuprofen; Inflammation; Metabo | 2021 |
Cardiovascular Outcomes in Systemic Lupus Erythematosus.
Topics: Aspirin; Cardiovascular Diseases; Disease Progression; Humans; Inflammation; Lupus Erythematosus, Sy | 2022 |
Resolvin D1: A key endogenous inhibitor of neuroinflammation.
Topics: Anti-Inflammatory Agents; Aspirin; Docosahexaenoic Acids; Humans; Inflammation; Neuroinflammatory Di | 2022 |
Updates on immune mechanisms in aspirin-exacerbated respiratory disease.
Topics: Animals; Aspirin; Asthma, Aspirin-Induced; Cyclooxygenase 1; Inflammation; Leukotrienes | 2023 |
An Aspirin a Day: New Pharmacological Developments and Cancer Chemoprevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemoprevention; Humans; Inflammation; Neoplasms | 2023 |
A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Humans; Inflammation; Pep | 2023 |
A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Humans; Inflammation; Pep | 2023 |
A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Humans; Inflammation; Pep | 2023 |
A Review on Herbal Drugs Used in the Treatment of Peptic Ulcer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Humans; Inflammation; Pep | 2023 |
Intravenous immunoglobulin for the treatment of Kawasaki disease.
Topics: Acute Coronary Syndrome; Aspirin; Child; Fever; Humans; Immunoglobulins, Intravenous; Inflammation; | 2023 |
Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren's syndrome.
Topics: Aspirin; Humans; Inflammation; Lipids; Salivary Glands; Sjogren's Syndrome | 2022 |
The role of non-steroidal anti-inflammatory drugs as adjuncts to periodontal treatment and in periodontal regeneration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Inflammation; Periodontitis; Regeneration | 2023 |
The great obstetrical syndromes and the placenta.
Topics: Aspirin; Female; Humans; Infant, Newborn; Inflammation; Placenta; Pre-Eclampsia; Pregnancy; Prematur | 2023 |
Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; COVID-19; Inflammation; Lipoxins; Mammals | 2023 |
Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications.
Topics: Aspirin; Drug Repositioning; Humans; Ibuprofen; Inflammation; Spinal Cord Injuries | 2023 |
Acetylsalicylic acid and its metabolite gentisic acid may act as adjunctive agents in the treatment of psychiatric disorders.
Topics: Anti-Inflammatory Agents; Antioxidants; Aspirin; Bipolar Disorder; Gentisates; Humans; Inflammation; | 2019 |
Analyzing Preeclampsia as the Tip of the Iceberg Represented by Women with Long-Term Cardiovascular Disease, Atherosclerosis, and Inflammation.
Topics: Aspirin; Atherosclerosis; Female; Humans; Hypertension; Inflammation; Placenta; Placentation; Pre-Ec | 2020 |
The impact of metformin and aspirin on T-cell mediated inflammation: A systematic review of in vitro and in vivo findings.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Diabetes Mellitu | 2020 |
Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?
Topics: Anti-Inflammatory Agents; Aspirin; Betacoronavirus; Blood Coagulation; Coronavirus Infections; COVID | 2020 |
Platelets in chronic obstructive pulmonary disease: An update on pathophysiology and implications for antiplatelet therapy.
Topics: Aspirin; Blood Platelets; Disease Progression; Elastin; Electron Transport; Humans; Inflammation; Lu | 2020 |
COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?
Topics: Adrenal Cortex Hormones; Aspirin; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 | 2021 |
Rationales and uncertainties for aspirin use in COVID-19: a narrative review.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; COVID-19; Humans; Inflammation; Middl | 2021 |
Innate immune cell dysregulation drives inflammation and disease in aspirin-exacerbated respiratory disease.
Topics: Animals; Aspirin; Asthma, Aspirin-Induced; Cytokines; Humans; Immunity, Innate; Inflammation; Leukoc | 2021 |
Inflammation-Related Pancreatic Carcinogenesis: Mechanisms and Clinical Potentials in Advances.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Humans; | 2017 |
[Aspirin and colorectal cancer].
Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Class I Phosphat | 2018 |
[Atherothrombosis : Novel therapeutic strategies].
Topics: Animals; Anticoagulants; Aspirin; Carrier Proteins; Clinical Trials as Topic; Humans; Hydroxymethylg | 2018 |
Potential of anti-inflammatory agents for treatment of atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Atherosclerosis; Colchicine; Cyclooxygenase 2 Inhibitors | 2018 |
Antithrombotic therapy management of adult and pediatric cardiac surgery patients.
Topics: Adolescent; Adult; Anticoagulants; Aspirin; Blood Coagulation; Cardiac Surgical Procedures; Cardiolo | 2018 |
The role of aspirin and inflammation on reproduction: the EAGeR trial
Topics: Animals; Aspirin; Female; Humans; Inflammation; Pregnancy; Pregnancy Outcome; Reproduction | 2019 |
[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians].
Topics: Adult; Aspirin; Biomarkers; Endoglin; Endothelium, Vascular; Female; Humans; Immune Tolerance; Infla | 2019 |
Effectiveness of Antiplatelet Drugs Under Therapeutic Hypothermia: A Comprehensive Review.
Topics: Aspirin; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Body Temperature; Combined Mod | 2019 |
Immunoinflammatory responses in gastrointestinal tract injury and recovery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biogenic Polyamines; Biomarkers; Cyc | 2013 |
Aspirin: a potential therapeutic approach in pancreatic cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cycloox | 2013 |
Role of platelets in inflammation and cancer: novel therapeutic strategies.
Topics: Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Colorectal Neoplasms; Cyclooxygenase 2; | 2014 |
Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment.
Topics: AMP-Activated Protein Kinases; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Repositioning; | 2014 |
Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Docosahexaenoic Acids; Humans; Inflammation; Lipoxygenas | 2015 |
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Docosahexaenoic Acids; Fat | 2015 |
Lipoxins and aspirin-triggered lipoxins in resolution of inflammation.
Topics: Animals; Aspirin; Humans; Inflammation; Inflammation Mediators; Lipoxins; Signal Transduction | 2015 |
Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cell Communication; Humans; Inflammatio | 2015 |
Pathways involved in the resolution of inflammatory joint disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Docosahexaenoic Acids; Humans; Inflamma | 2015 |
Platelets at the interface of thrombosis, inflammation, and cancer.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Blood Platelets; Cell Death; Cell Proliferation; Cell-Der | 2015 |
New Insights into the Mechanism of Action of Aspirin in the Prevention of Colorectal Neoplasia.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Blood Platelets; Colorectal Neoplasms; Dose-Response Rela | 2015 |
Kawasaki disease: a comprehensive review of treatment options.
Topics: Aspirin; Coronary Artery Disease; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; In | 2015 |
Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Chemoprevention; Cycloox | 2016 |
Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa.
Topics: Angiogenesis Inducing Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Aspi | 2017 |
Asthma: a syndrome composed of heterogeneous diseases.
Topics: Allergens; Aspirin; Asthma; Cytokines; Eosinophils; Humans; Immunoglobulin E; Inflammation; Mast Cel | 2008 |
Hyperleukotrieneuria in patients with allergic and inflammatory disease.
Topics: Aspirin; Asthma; Biomarkers; Cell Movement; Drug Hypersensitivity; Eosinophils; Gene Expression Regu | 2008 |
Post-cardiac injury syndrome following transvenous pacemaker insertion: A case report and review of the literature.
Topics: Aged; Aspirin; Heart Injuries; Humans; Iatrogenic Disease; Inflammation; Male; Pacemaker, Artificial | 2009 |
Resolvins: Current understanding and future potential in the control of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; In | 2009 |
Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cell Adhesion Molecules; | 2009 |
From IL-15 to IL-33: the never-ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Delivery Systems; Humans; Inflammati | 2010 |
Lipoxins: resolutionary road.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Inflammation; Lipoxins; Macrophages; Neutrophils; Phagoc | 2009 |
Eicosanoids and the endogenous control of acute inflammatory resolution.
Topics: Acute Disease; Animals; Aspirin; Eicosanoids; Feedback, Physiological; Humans; Immunity, Innate; Inf | 2010 |
Rhinosinusitis and comorbidities.
Topics: Anti-Bacterial Agents; Aspirin; Cystic Fibrosis; Humans; Hypersensitivity; Immunity, Humoral; Immuno | 2010 |
Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 | 2010 |
[Clopidogrel and stroke].
Topics: Acute Disease; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Inflamm | 2011 |
"Aspirin - resistance"? A few critical considerations on definition, terminology, diagnosis, clinical value, natural course of atherosclerotic disease, and therapeutic consequences.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Bleeding Time; Drug Resistance; H | 2011 |
Therapeutic potential of new hydrogen sulfide-releasing hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Humans; Hydrogen Sulfide; Inf | 2011 |
Aspirin and immune system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Autoimmune Diseases; Dendritic Cells; Gra | 2012 |
Pancreas graft thrombosis: causes, prevention, diagnosis, and intervention.
Topics: Acute Disease; Anticoagulants; Aspirin; Fibrinolytic Agents; Graft Rejection; Heparin; Humans; Incid | 2012 |
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2012 |
Do aspirin and statins prevent severe sepsis?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Hydroxymethylglutaryl-CoA Reducta | 2012 |
Manifold beneficial effects of acetyl salicylic acid and nonsteroidal anti-inflammatory drugs on sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Dose-Response Rel | 2012 |
Preeclampsia 2012.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Aspirin; Biomarkers; Calcium | 2012 |
Preeclampsia 2012.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Aspirin; Biomarkers; Calcium | 2012 |
Preeclampsia 2012.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Aspirin; Biomarkers; Calcium | 2012 |
Preeclampsia 2012.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Aspirin; Biomarkers; Calcium | 2012 |
Cancer prevention by targeting angiogenesis.
Topics: Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; | 2012 |
Sex differences in effects and use of anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibit | 2012 |
Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Aspirin; Asthma; Cell | 2002 |
Statins: the new aspirin?
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Apoptosis | 2002 |
Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Aspirin; Humans; Hyd | 2003 |
Nasal polyposis: an update: editorial review.
Topics: Aspirin; Cytokines; Eosinophils; Epithelial Cells; Humans; Hypersensitivity; Inflammation; Mast Cell | 2003 |
Nonplatelet-mediated effects of aspirin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Humans; Inflammation; M | 2002 |
The role of chronic inflammation in cardiovascular mortality of uremic patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C-Reactive Protein; Cardiovascular Diseases; Human | 2003 |
Lipoxins in chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Eicosanoids; Humans; Hyd | 2003 |
Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases.
Topics: Adjuvants, Immunologic; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Ster | 2003 |
Novel pathways and endogenous mediators in anti-inflammation and resolution.
Topics: Animals; Arachidonate 5-Lipoxygenase; Aspirin; Cell Communication; Humans; Hydroxyeicosatetraenoic A | 2003 |
The mechanism of action of aspirin.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase | 2003 |
The mechanism of action of aspirin.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase | 2003 |
The mechanism of action of aspirin.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase | 2003 |
The mechanism of action of aspirin.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase | 2003 |
Studies on the mechanism of action of anti-inflammatory drugs. A paper in honour of John Vane.
Topics: Animals; Annexins; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gluc | 2003 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
Coagulation, inflammation and myocardial dysfunction in unstable coronary artery disease and the influence of glycoprotein IIb/IIIa inhibition and low molecular weight heparin.
Topics: Acute Disease; Anticoagulants; Aspirin; Blood Coagulation Disorders; Coronary Disease; Heparin, Low- | 2004 |
Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acid | 2004 |
Atherosclerosis as an inflammatory disease: implications for therapy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Atherosclerosis; CD40 Antigens; Cytokine | 2004 |
[Inflammation and diabetes].
Topics: Adiponectin; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Arte | 2004 |
A marriage of enhancement: fibrinolysis and conjunctive therapy.
Topics: Animals; Antithrombins; Aspirin; Blood Platelets; Cell Adhesion; Clinical Trials as Topic; Dose-Resp | 2004 |
Prevention of cardiovascular disease in type-2 diabetes: how to improve the clinical efficacy of aspirin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Diseases; Diabetes Complications; | 2005 |
Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers.
Topics: Animals; Aspirin; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Humans; Inflam | 2004 |
Controlling inflammation: a fat chance?
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dietary Fats; Fatty Acids, Unsaturated; Humans; Inflamma | 2005 |
Interactions between Alzheimer's disease and cerebral ischemia--focus on inflammation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspirin; Brain Ischemia; Humans; Inflamm | 2005 |
Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Brain Ischemia; C-Reactive Prote | 2005 |
New insights into the anti-inflammatory actions of aspirin-induction of nitric oxide through the generation of epi-lipoxins.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Eicosanoids; Humans; Infla | 2005 |
Old and new drug targets in diabetic retinopathy: from biochemical changes to inflammation and neurodegeneration.
Topics: Aldehyde Reductase; Animals; Antioxidants; Aspirin; Blood-Retinal Barrier; Diabetic Retinopathy; Gly | 2005 |
Pathogenesis of nasal polyps: an update.
Topics: Aspirin; Bacterial Physiological Phenomena; Cytokines; Eosinophils; Fibroblasts; Fungi; Genetic Pred | 2005 |
"Anti-inflammatory" drugs and their effects on type 2 diabetes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Aspirin; Cardiotonic Agents; Dia | 2006 |
New frontiers for cardiac risk assessment: C-reactive protein.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarke | 2006 |
Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins.
Topics: Acetylation; Animals; Anti-Inflammatory Agents; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxy | 2006 |
Nitric oxide and inflammation.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Drug Evaluation | 2006 |
Lipoxins and new lipid mediators in the resolution of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Disease Models, Animal | 2006 |
NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Cell Pr | 2006 |
From willow bark to peptides: the ever widening spectrum of NF-kappaB inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Glucocorticoids | 2006 |
Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Docosahexaenoic Acids; | 2006 |
Novel chemical mediators in the resolution of inflammation: resolvins and protectins.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspiri | 2006 |
New perspectives on aspirin and the endogenous control of acute inflammatory resolution.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Doc | 2006 |
COX-2 in inflammation and resolution.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 2006 |
Vascular endothelium and atherosclerosis.
Topics: Animals; Aspirin; Atherosclerosis; Cell Adhesion Molecules; Cyclooxygenase Inhibitors; Cytokines; En | 2006 |
From pathophysiology to targeted therapy for atherothrombosis: a role for the combination of statin and aspirin in secondary prevention.
Topics: Animals; Apoptosis; Aspirin; Atherosclerosis; Cardiovascular Diseases; Cholesterol; Drug Therapy, Co | 2007 |
Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors.
Topics: Adolescent; Aspirin; Celecoxib; Child; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Interacti | 2006 |
Aspirin-sensitive rhinosinusitis and asthma.
Topics: Arachidonic Acid; Aspirin; Asthma; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Infl | 2007 |
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease.
Topics: Angina, Unstable; Aspirin; Atherosclerosis; Biomarkers; Blood Platelets; Clopidogrel; Humans; Inflam | 2007 |
How to advise aspirin use in patients who need NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase 2 Inhibito | 2007 |
Control of inflammation and periodontitis.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Aspirin; Biofilms; Bone Regeneration; Disease | 2007 |
New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Fatty Acids, Omega-3; Humans; Inflammation; Inflammation | 2007 |
Aspirin: recent developments.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Cyclooxygenase Inhibitors; H | 2008 |
Inflammatory genes in nasal polyposis.
Topics: Aspirin; Chemokines; Cytokines; Eosinophils; Gene Expression; Humans; Inflammation; Intercellular Si | 2008 |
Anti-inflammatory agents and antioxidants as a possible "third great wave" in cardiovascular secondary prevention.
Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Aspirin; Cardiovascular D | 2008 |
The biologic background to some therapeutic uses of aspirin.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Carotid Artery Diseases; Coronary Disease; Humans; In | 1983 |
Drug therapy: nonsteroidal antiinflammatory drugs (first of two parts).
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Child; Drug Tolerance; Female; Gastric Mucosa; Gastrit | 1980 |
Prostaglandins, macrophages, and immunity.
Topics: Arachidonic Acids; Aspirin; Cell Division; Cell Separation; Epoprostenol; Immunity, Cellular; Indome | 1980 |
Discovery of a better aspirin.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Carra | 1995 |
[Antiphlogistic effect of salicylic acid and its derivatives].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Humans; Inflammati | 1993 |
Effects of mesalazine on lamina propria white cell functions.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Clinical | 1995 |
Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Eicosanoids; En | 1995 |
Leukotrienes as mediators of airway obstruction and inflammation in asthma.
Topics: Airway Obstruction; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid | 1995 |
The role of inflammation in atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Endothelium, Vascular; | 1996 |
[Importance of in vivo and in vitro studies of leukotrienes. Application to the particular instance of aspirin].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Body Fluids; Cells, Cultured; Drug Hyp | 1997 |
NO-aspirins: a class of new anti-inflammatory and antithrombotic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Cyclooxygenase Inhi | 1999 |
[Aspirin, pain and inflammation].
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Child; Colic; Controlle | 2000 |
Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Autacoids; Cytokines; Humans; Hydroxyeico | 2001 |
Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc | 2001 |
Genetic and pharmacological analysis of prostanoid receptor function.
Topics: Animals; Aspirin; Biological Transport; Bone Resorption; Cell Nucleus; Colonic Neoplasms; Cyclooxyge | 2001 |
Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side.
Topics: Animals; Arachidonate 5-Lipoxygenase; Aspirin; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; I | 2001 |
[From the physiopathology of thrombosis to therapeutic targets].
Topics: Arteriosclerosis; Aspirin; Fibrinolytic Agents; Humans; Inflammation; Ischemia; Platelet Aggregation | 2001 |
Analgesia and cyclo-oxygenase inhibitors.
Topics: Analgesics; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase | 2001 |
Use of statins and aspirin to reduce risks of cardiovascular disease.
Topics: Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Drug Synergism; Humans; Hydroxymethylglu | 2002 |
Pharmacology of antiarthritic drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Bone Resorption; Cattle; Cyclooxygenase Inhib | 1978 |
Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Arthritis; Ascariasis; Aspirin; Cattle; Cattle Disea | 1977 |
[Analgesics: pharmacologic properties as a basis for rational therapy].
Topics: Acetylcholine; Aminopyrine; Analgesics; Animals; Aspirin; Central Nervous System; Dogs; Encephalitis | 1978 |
The role of prostaglandins in inflammation.
Topics: Animals; Aspirin; Capillary Permeability; Exudates and Transudates; Guinea Pigs; Inflammation; Prost | 1978 |
Steroids, aspirin, and inflammation.
Topics: Animals; Aspirin; Cell Membrane; Chemotaxis; Cytoplasmic Granules; Glucocorticoids; Humans; Infectio | 1977 |
Mode of action of aspirin-like drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Chemical Phenomena; Chemistry; | 1979 |
The mode of action of aspirin and similar compounds.
Topics: Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Bronchi; Dermatitis, Atopic; Drug Hypersensiti | 1976 |
Prostaglandins-a short review.
Topics: Aspirin; Blood Platelets; Bronchi; Cardiovascular System; Drug Interactions; Female; Fever; Gastric | 1975 |
[Kawasaki syndrome].
Topics: Aspirin; Child, Preschool; Coronary Aneurysm; Female; gamma-Globulins; Heart Diseases; Humans; Infan | 1990 |
Clinical pharmacology and use of nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis, Juvenile; A | 1989 |
Prostaglandins and other metabolites of arachidonic acid. An overview for the otolaryngologist.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blo | 1985 |
Vitamin C and chiropractic.
Topics: Age Factors; Alcoholism; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ascorbic Acid; As | 1985 |
Prevention of cecitis in hamsters by certain prostaglandins.
Topics: Animals; Aspirin; Castor Oil; Cecal Diseases; Clindamycin; Cricetinae; Indomethacin; Inflammation; M | 1985 |
Current trends in the research on antiinflammatory agents.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzydam | 1985 |
Microvascular ultrastructure in thermal injury: a reconsideration of the role of mediators.
Topics: Animals; Aspirin; Bradykinin; Burns; Capillaries; Carbon Isotopes; Coloring Agents; Guinea Pigs; His | 1973 |
Aspirin: the unique drug.
Topics: Aspirin; Blood Platelets; Drug Interactions; Drug Synergism; Gastrointestinal Hemorrhage; Hemorrhage | 1974 |
[Clinical use of non-steroid anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthritis, Rheumatoid; Aspirin; Cell Mi | 1974 |
Inhibition of prostaglandin biosynthesis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cats; Cattle; Depression, Chemical; Dogs; Fa | 1974 |
Inflammation, prostaglandins and aspirin-like drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Cardiovascular System; Cell Move | 1973 |
Sites and modes of action of antipyretic-analgesic drugs.
Topics: Analgesics; Animals; Aspirin; Body Temperature Regulation; Bradykinin; Humans; Hydrocortisone; Hypot | 1969 |
A pharmacological analysis of aspirin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Blood Chemical Analysis; Bradykinin; Bronchi | 1969 |
A pharmacological analysis of aspirin.
Topics: Animals; Aspirin; Blood Chemical Analysis; Blood Coagulation; Cats; Dogs; Fever; Gastric Mucosa; Gui | 1969 |
75 trials available for aspirin and Innate Inflammatory Response
| Article | Year |
|---|---|
Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention.
Topics: Aspirin; Cardiovascular Diseases; Eicosanoids; HIV Infections; Humans; Inflammation; Inflammation Me | 2023 |
Nonsteroidal Anti-inflammatory Drug (NSAID) Tolerance After Biological Therapy in Patients With NSAID-Exacerbated Respiratory Disease: A Randomized Comparative Trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Biological Therapy; Humans; Inflammation; | 2023 |
The efficacy of aspirin to inhibit platelet aggregation in patients hospitalised with a severe infection: a multicentre, open-label, randomised controlled trial.
Topics: Aspirin; Blood Platelets; Female; Humans; Inflammation; Platelet Aggregation; Platelet Aggregation I | 2023 |
An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV.
Topics: Anti-Retroviral Agents; Aspirin; Atorvastatin; Cardiovascular Diseases; CD4 Lymphocyte Count; Female | 2023 |
Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Dose-Response Relationship, Drug; Doub | 2019 |
Pilot randomized trial of short-term changes in inflammation and lipid levels during and after aspirin and pravastatin therapy.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Bioma | 2019 |
Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development.
Topics: Adenocarcinoma; Animals; Aspirin; Barrett Esophagus; Carcinogenesis; Cell Line, Tumor; Cell Prolifer | 2019 |
Synergistic influence of rivaroxaban on inflammation and coagulation biomarkers in patients with coronary artery disease and peripheral artery disease on aspirin therapy.
Topics: Aged; Aspirin; Biomarkers; Blood Coagulation; Coronary Artery Disease; Drug Therapy, Combination; Fa | 2020 |
Use of Aspirin and Statins in Relation to Inflammation in Benign Prostate Tissue in the Placebo Arm of the Prostate Cancer Prevention Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Double-Blind Method; H | 2020 |
Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians' Health Study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Frailty; Humans; Inflamma | 2021 |
Administration of acetylsalicylic acid after parturition in lactating dairy cows under certified organic management: Part II. Biomarkers of nociception, inflammation, and stress.
Topics: Animals; Aspirin; Biomarkers; Cattle; Cattle Diseases; Dystocia; Female; Haptoglobins; Hydrocortison | 2020 |
Preconception Low-Dose Aspirin Restores Diminished Pregnancy and Live Birth Rates in Women With Low-Grade Inflammation: A Secondary Analysis of a Randomized Trial.
Topics: Abortion, Spontaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Rate; C-Reacti | 2017 |
Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women.
Topics: Adult; Aspirin; beta Catenin; Carcinogenesis; Cross-Over Studies; Double-Blind Method; Female; Human | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cy | 2017 |
Firefighting Induces Acute Inflammatory Responses that are not Relieved by Aspirin in Older Firefighters.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Cross-Over Studies | 2019 |
Targeting thrombogenicity and inflammation in chronic HIV infection.
Topics: Adult; Anti-Inflammatory Agents; Antiretroviral Therapy, Highly Active; Aspirin; Biomarkers; Blood P | 2019 |
Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study.
Topics: Adenosine Diphosphate; Adult; Aged; Anti-HIV Agents; Arachidonic Acid; Aspirin; Cells, Cultured; Col | 2013 |
Effects of the precalving administration of omega-3 fatty acids alone or in combination with acetylsalicylic acid in periparturient dairy cows.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Dietary Sup | 2013 |
Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results.
Topics: Aged; Angiography, Digital Subtraction; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebral A | 2013 |
A pilot trial to examine the effect of high-dose niacin on arterial wall inflammation using fluorodeoxyglucose positron emission tomography.
Topics: Aorta; Aspirin; Atherosclerosis; Carotid Arteries; Double-Blind Method; Female; Fluorodeoxyglucose F | 2015 |
Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Colorectal Neoplasms; Early Dete | 2015 |
Effects of CYP2C19 Polymorphism on Endothelial Function, Arterial Stiffness and Inflammation in Coronary Artery Disease Patients Under Clopidogrel Treatment.
Topics: Aged; Aged, 80 and over; Aspirin; Brachial Artery; Clopidogrel; Coronary Artery Disease; Cytochrome | 2015 |
Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes.
Topics: Aged; Alleles; Aspirin; Blood Platelets; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Type | 2016 |
Anti-platelet drugs attenuate the expansion of circulating CD14highCD16+ monocytes under pro-inflammatory conditions.
Topics: Adult; Aspirin; Biomarkers; C-Reactive Protein; Cell Proliferation; Clopidogrel; Cytokines; Female; | 2016 |
Inflammatory biomarkers, aspirin, and risk of colorectal cancer: Findings from the physicians' health study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; C-Reactive Protein; Case-Control Studies; Colorectal Neopla | 2016 |
ASPREE-D: Aspirin for the prevention of depression in the elderly.
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Depression; Double-Blind Method; Female; Humans; Inflammati | 2016 |
New single-nucleotide polymorphisms associated with differences in platelet reactivity and their influence on survival in patients with type 2 diabetes treated with acetylsalicylic acid: an observational study.
Topics: Aged; Alleles; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Female; Genotype; H | 2017 |
Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Bronchoalveolar Lavage; C-React | 2017 |
AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antisepsis; Aspirin; Australia; Fe | 2017 |
The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug Therapy, Combination; Fema | 2008 |
Efficacy of clopidrogel on reperfusion and high-sensitivity C-reactive protein in patients with acute myocardial infarction.
Topics: Aspirin; C-Reactive Protein; Clopidogrel; Coronary Circulation; Creatine Kinase, MB Form; Drug Thera | 2009 |
Effects of low-dose aspirin on acute inflammatory responses in humans.
Topics: Acute Disease; Aspirin; Blister; Cantharidin; Cell Adhesion; Chemotaxis, Leukocyte; Dose-Response Re | 2009 |
Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia.
Topics: Aspirin; Atherosclerosis; Biomarkers; Blood Viscosity; C-Reactive Protein; Cognition Disorders; Exec | 2009 |
Use of heparin in women with early and late miscarriages with and without thrombophilia.
Topics: Abortion, Habitual; Adult; Age Factors; Aspirin; Biomarkers; Case-Control Studies; Dalteparin; Drug | 2009 |
Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome.
Topics: Adult; Aged; Anti-Inflammatory Agents; Aspirin; Biomarkers; C-Reactive Protein; Cardiovascular Disea | 2009 |
Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways.
Topics: Adult; Aspirin; Humans; Inflammation; Lipoxins; Male; Middle Aged; Receptors, Formyl Peptide; Recept | 2010 |
The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Biomarkers; Chronic Disease; | 2010 |
Treatment with an oral direct thrombin inhibitor decreases platelet activity but increases markers of inflammation in patients with myocardial infarction.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antithrombins; Aspirin; Azetidines; Benzylamines; Bio | 2011 |
Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake.
Topics: Adult; Aspirin; Atherosclerosis; Blood Platelets; CD40 Ligand; Cell Communication; Cells, Cultured; | 2011 |
Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; CD40 Ligand; Cyclooxygenase 1; Fem | 2011 |
Acetylsalicylic acid treatment until surgery reduces oxidative stress and inflammation in patients undergoing coronary artery bypass grafting.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; C-Reactive Protein; Coronary Artery Bypass; Dinoprost; Drug | 2013 |
Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets.
Topics: Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cells, Cultured | 2003 |
Influence of aspirin on inflammatory markers in patients after acute myocardial infarction.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Biomarkers; C-Reactiv | 2003 |
Leukocyte count as an independent predictor of recurrent ischemic events.
Topics: Aspirin; Biomarkers; Brain Ischemia; Cause of Death; Clopidogrel; Female; Humans; Inflammation; Leuk | 2004 |
Coagulation, inflammation and myocardial dysfunction in unstable coronary artery disease and the influence of glycoprotein IIb/IIIa inhibition and low molecular weight heparin.
Topics: Acute Disease; Anticoagulants; Aspirin; Blood Coagulation Disorders; Coronary Disease; Heparin, Low- | 2004 |
Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Biomarkers; Brachial Artery; C-Rea | 2004 |
Cyclooxygenase-mediated prostaglandin F2alpha is decreased in an elderly population treated with low-dose aspirin.
Topics: Aged; alpha-Tocopherol; Antioxidants; Aspirin; C-Reactive Protein; Dinoprost; gamma-Tocopherol; Huma | 2005 |
The HOPE (Heart Outcomes Prevention Evaluation) Study and its consequences.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cost-Benefit Analysis; Diabetes Complications; Fe | 2005 |
Pioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patients.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Coronary Disease; C | 2005 |
Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome.
Topics: Adult; Aged; Angina, Unstable; Aspirin; C-Reactive Protein; Clopidogrel; Drug Therapy, Combination; | 2006 |
No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease.
Topics: Aspirin; Biomarkers; Chemokine CCL2; Clopidogrel; Coronary Disease; Humans; Inflammation; Ticlopidin | 2006 |
Naproxen treatment prevents periprocedural inflammatory response but not myocardial injury after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C-Reactive P | 2007 |
Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antithrombins; Aspirin; Atorvastatin; Blood Platelets | 2006 |
Relation between impaired antiplatelet response to clopidogrel and possible pleiotropic effects.
Topics: Aged; Aspirin; Blood Platelets; C-Reactive Protein; Clopidogrel; Drug Resistance; Female; Humans; In | 2007 |
Persistent platelet activation in patients with type 2 diabetes treated with low doses of aspirin.
Topics: Aspirin; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Glycemic Index; | 2007 |
Pro- and anti-inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Cytokines; Humans; Inflammation | 2006 |
Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Breath Tests; Bronchial Provocation | 2008 |
[Clinical trial of guacetisal in aged subjects with inflammatory diseases of the respiratory tract].
Topics: Aged; Anti-Inflammatory Agents; Aspirin; Bronchitis; Clinical Trials as Topic; Common Cold; Female; | 1982 |
Comparative analgesic efficacies of aspirin and acetaminophen.
Topics: Acetaminophen; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Inflamma | 1981 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; C- | 1997 |
Patterns of hyperalgesia in complex regional pain syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Hot Temperature; Humans; Hyperalgesia; Inf | 1999 |
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation.
Topics: Adult; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2000 |
Antithrombotic treatment (argatroban vs. heparin) in coronary angioplasty in angina pectoris: effects on inflammatory, hemostatic, and endothelium-derived parameters.
Topics: Aged; alpha-2-Antiplasmin; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Antithro | 2000 |
Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Aspirin; Biomarkers; Brachial Artery; C-Reactive Protein | 2000 |
Salasalate for HIV.
Topics: Aspirin; Double-Blind Method; HIV Infections; Humans; Inflammation; Placebos | 1995 |
Cromolyn sodium suppresses eosinophilic inflammation in patients with aspirin-intolerant asthma.
Topics: Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Blood Protei | 2001 |
Prevention of inflammation-induced endothelial dysfunction: a novel vasculo-protective action of aspirin.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brachial Artery; Brad | 2002 |
Indomethacin--aspirin interaction: a clinical appraisal.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Interactions; Humans; Indomethacin; I | 1975 |
Fenoprofen calcium versus aspirin in the treatment of acute inflammatory soft-tissue injuries.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Fenoprofen; Humans; Inf | 1985 |
Penicillin control of swelling and pain after periodontal osseous surgery.
Topics: Administration, Oral; Adult; Alveoloplasty; Aspirin; Female; Humans; Inflammation; Male; Middle Aged | 1974 |
The clinical evaluation of anti-arthritic drugs.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Clinical Trials as Topic; | 1972 |
Double-blind comparison of aspirin and 4-(acetamido) phenyl-2-acetoxy-benzoate (benorylate) in rheumatoid arthritis.
Topics: Acetanilides; Acetates; Analgesics; Arthritis, Rheumatoid; Aspirin; Blood Sedimentation; Clinical Tr | 1973 |
Oral bromelains as adjuncts in the treatment of acute thrombophlebitis.
Topics: Acute Disease; Adult; Aged; Aspirin; Bromelains; Clinical Trials as Topic; Codeine; Female; Humans; | 1969 |
An experimental model of acute inflammation in man.
Topics: Adult; Aspirin; Clinical Trials as Topic; Colchicine; Humans; Inflammation; Knee Joint; Male; Methyl | 1966 |
Effect of non-steroidal anti-inflammatory drugs on osteoarthritis of the knee. With special reference to PSP clearance as an indicator.
Topics: Aspirin; Humans; Indomethacin; Inflammation; Knee Joint; Osteoarthritis; Phenylbutazone; Physical Th | 1970 |
545 other studies available for aspirin and Innate Inflammatory Response
| Article | Year |
|---|---|
Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Inflammation; Mice; Naloxone; Pyri | 1978 |
Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5,5]undec-1-enes and related compounds.
Topics: Analgesics; Animals; Female; Inflammation; Lethal Dose 50; Male; Mice; Quinones; Rats; Reaction Time | 1978 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenom | 1989 |
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; | 2001 |
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhib | 2008 |
Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity.
Topics: Acetates; Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri | 2008 |
Toward the development of chemoprevention agents (III): synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzene Derivatives; Chemoprevention; Inflammation | 2008 |
Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives.
Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Drug Design; Fungi; | 2008 |
10H-Phenothiazines: a new class of enzyme inhibitors for inflammatory diseases.
Topics: Anti-Inflammatory Agents; Asthma; Autoimmune Diseases; Enzyme Inhibitors; Humans; Inflammation; Phen | 2009 |
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Esters; Hydrazines; Inflammation; Mo | 2008 |
Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Celecoxib; Edema; Inflammation; Nitric Oxid | 2008 |
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Topics: Acetylene; Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Cyc | 2009 |
Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives.
Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Hydrazones; Inf | 2009 |
3-Formylchromones: potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromones; Cyclooxygenase Inhibitors; | 2010 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Hydrogen Bonding; Inflammation; Lung Dise | 2016 |
Kojyl cinnamate esters are peroxisome proliferator-activated receptor α/γ dual agonists.
Topics: Adipogenesis; Adiponectin; Cinnamates; Dinoprostone; Humans; Inflammation; Keratinocytes; Matrix Met | 2018 |
Eicosanoid dysregulation and type 2 inflammation in AERD.
Topics: Aspirin; Biomarkers; Disease Susceptibility; Eicosanoids; Humans; Inflammation; Respiratory Tract Di | 2021 |
Utility of Platelet Endothelial Cell Adhesion Molecule 1 in the Platelet Activity Assessment in Mouse and Human Blood.
Topics: Animals; Aspirin; Blood Platelets; Cell Adhesion; Endothelial Cells; Endothelium, Vascular; Female; | 2021 |
Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis.
Topics: Animals; Aspirin; Blood Platelets; Brain; CD4-Positive T-Lymphocytes; Disease Models, Animal; Dose-R | 2021 |
Urinary 11-dehydrothromboxane B2 aspirin efficacy testing is sensitive to perioperative inflammation in pediatric solid-organ transplant patients.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Child; Child, Preschool; Humans; Infant; Infant, Newbor | 2022 |
Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle.
Topics: Animal Feed; Animals; Aspirin; Body Composition; Cattle; Cattle Diseases; Diet; Female; Inflammation | 2021 |
ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice.
Topics: Acute Kidney Injury; Albumins; Animals; Aspirin; Biomarkers; Cytokines; Disease Models, Animal; Doco | 2021 |
Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry.
Topics: Aspirin; COVID-19 Drug Treatment; Humans; Inflammation; Intensive Care Units; Registries; Retrospect | 2022 |
Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer.
Topics: Animals; Aspirin; CD8-Positive T-Lymphocytes; Colitis-Associated Neoplasms; Inflammation; Macrophage | 2022 |
The inhibiting effect of Aspirin Triggered-Resolvin D1 in non-canonical pyroptosis in rats with acute keratitis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Caspases; Docosahexaenoic Acids; Inflammation; Keratitis | 2022 |
Lipoxins in inflammation.
Topics: Anti-Inflammatory Agents; Aspirin; Dinoprostone; Humans; Inflammation; Inflammation Mediators; Lipox | 2022 |
Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease.
Topics: Aspirin; Asthma, Aspirin-Induced; Chronic Disease; Eosinophilia; Epithelial Cells; Humans; Inflammat | 2022 |
Role of Combination Treatment of Aspirin and Zinc in DMH-DSS-induced Colon Inflammation, Oxidative Stress and Tumour Progression in Male BALB/c Mice.
Topics: Animals; Antioxidants; Aspirin; Colitis; Colitis-Associated Neoplasms; Colon; Disease Models, Animal | 2023 |
Anti-inflammatory and antioxidant effect of methanol extract of latex of Calotropis procera in rat model of colorectal cancer.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aspirin; Calotropis; Carcinogens; Colorectal Neopla | 2022 |
Topical Aspirin Administration Improves Cutaneous Wound Healing in Diabetic Mice Through a Phenotypic Switch of Wound Macrophages Toward an Anti-inflammatory and Proresolutive Profile Characterized by LXA4 Release.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aspirin; Diabetes Mellitus, Experimental | 2022 |
Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Aspirin; Blood Glucose; Body Weight; Diet, High-F | 2022 |
Aspirin-Mediated Reset of Preeclamptic Placental Stem Cell Transcriptome - Implication for Stabilized Placental Function.
Topics: Aspirin; Female; Humans; Inflammation; Mesenchymal Stem Cells; Placenta; Pre-Eclampsia; Pregnancy; S | 2022 |
Aspirin Protects against UVB-Induced DNA Damage through Activation of AMP Kinase.
Topics: Adenosine Monophosphate; Adenylate Kinase; Animals; Aspirin; Cyclooxygenase Inhibitors; DNA Damage; | 2023 |
Aspirin Inhibits Carcinogenesis of Intestinal Mucosal Cells in UC Mice Through Inhibiting IL-6/JAK/STAT3 Signaling Pathway and Modulating Apoptosis and Proliferation.
Topics: Animals; Apoptosis; Aspirin; Azoxymethane; Carcinogenesis; Cell Proliferation; Colitis, Ulcerative; | 2022 |
Targeting the Leukotriene Pathway for Colon Cancer Interception.
Topics: Aberrant Crypt Foci; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidon | 2022 |
Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report.
Topics: Anti-Bacterial Agents; Aspirin; Calcinosis; Calcium; Cerebral Infarction; Female; Fibrin; Fibrinolyt | 2022 |
Differential effects of acetylsalicylic acid and mitomycin C on cytokine-induced Tenon's capsule myofibroblast transdifferentiation and activity: Implications for glaucoma surgery.
Topics: Aspirin; Cell Transdifferentiation; Cells, Cultured; Chromatography, Liquid; Cicatrix; Collagen; Cyt | 2022 |
The protective effect of rivaroxaban with or without aspirin on inflammation, oxidative stress, and platelet reactivity in isoproterenol-induced cardiac injury in rats.
Topics: Animals; Aspirin; Biomarkers; Factor Xa Inhibitors; Heart Injuries; Inflammation; Isoproterenol; Mal | 2023 |
Aspirin Inhibits the Inflammatory Response of Protease-Activated Receptor 1 in Pregnancy Neutrophils: Implications for Treating Women with Preeclampsia.
Topics: Aspirin; Bicyclic Monoterpenes; Cyclooxygenase 2; Female; Humans; Inflammation; Neutrophils; Peptide | 2022 |
Low-dose aspirin protects unexplained recurrent spontaneous abortion
Topics: Abortion, Spontaneous; Animals; Aspirin; Down-Regulation; Female; HMGB1 Protein; Humans; Infant; Inf | 2022 |
Low-dose aspirin protects unexplained recurrent spontaneous abortion
Topics: Abortion, Spontaneous; Animals; Aspirin; Down-Regulation; Female; HMGB1 Protein; Humans; Infant; Inf | 2022 |
Low-dose aspirin protects unexplained recurrent spontaneous abortion
Topics: Abortion, Spontaneous; Animals; Aspirin; Down-Regulation; Female; HMGB1 Protein; Humans; Infant; Inf | 2022 |
Low-dose aspirin protects unexplained recurrent spontaneous abortion
Topics: Abortion, Spontaneous; Animals; Aspirin; Down-Regulation; Female; HMGB1 Protein; Humans; Infant; Inf | 2022 |
C-Phycocyanin and
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspirin; bcl-2-Associated X Protein; Drugs, Chinese He | 2022 |
C-Phycocyanin and
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspirin; bcl-2-Associated X Protein; Drugs, Chinese He | 2022 |
C-Phycocyanin and
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspirin; bcl-2-Associated X Protein; Drugs, Chinese He | 2022 |
C-Phycocyanin and
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspirin; bcl-2-Associated X Protein; Drugs, Chinese He | 2022 |
Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration.
Topics: Acute Lung Injury; Animals; Aspirin; Humans; Inflammation; Lung; Lung Neoplasms; Mice; Neutrophil In | 2023 |
Dual Pathway Inhibition with Rivaroxaban and Aspirin Reduces Inflammatory Biomarkers in Atherosclerosis.
Topics: Aged; Aspirin; Atherosclerosis; Biomarkers; Coronary Artery Disease; Drug Therapy, Combination; Fact | 2023 |
Low-dose aspirin and prevention of preterm birth: untold story of inflammation.
Topics: Aspirin; Female; Humans; Infant, Newborn; Inflammation; Platelet Aggregation Inhibitors; Pre-Eclamps | 2023 |
Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells.
Topics: Aspirin; Cyclooxygenase 2; Cytokines; Eicosanoids; Endothelial Cells; Humans; Inflammation; Lipoxins | 2023 |
Aspirin ameliorates atherosclerotic immuno-inflammation through regulating the Treg/Th17 axis and CD39-CD73 adenosine signaling via remodeling the gut microbiota in ApoE
Topics: Adenosine; Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Gastrointestinal Microbiome; Inflam | 2023 |
Aspirin loaded extracellular vesicles inhibit inflammation of macrophages via switching metabolic phenotype in periodontitis.
Topics: Animals; Aspirin; Extracellular Vesicles; Inflammation; Lipopolysaccharides; Macrophages; Mice; Peri | 2023 |
Comparative structural study of selective and non-selective NSAIDs against the enzyme cyclooxygenase-2 through real-time molecular dynamics linked to post-dynamics MM-GBSA and e-pharmacophores mapping.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Humans; Inflammation; | 2023 |
ALX/FPR2 Activation by Stereoisomers of D1 Resolvins Elucidating with Molecular Dynamics Simulation.
Topics: Aspirin; Humans; Inflammation; Molecular Dynamics Simulation; Receptors, Formyl Peptide; Receptors, | 2023 |
Mechanism of Xiaojianzhong decoction in alleviating aspirin-induced gastric mucosal injury revealed by transcriptomics and metabolomics.
Topics: Aspirin; Drugs, Chinese Herbal; Gastric Mucosa; Humans; Inflammation; Metabolomics; Molecular Dockin | 2024 |
Long-term aspirin administration suppresses inflammation in diabetic cystopathy.
Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Inflammation; Male; Ra | 2023 |
Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease.
Topics: Animals; Aspirin; Asthma; Asthma, Aspirin-Induced; Diabetes Mellitus, Type 2; Glucagon-Like Peptide- | 2023 |
Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression.
Topics: Animals; Aspirin; B7-H1 Antigen; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Liver | 2023 |
FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Curcumin; Disease Progression; | 2019 |
Response to Letter to the Editor "Is Aspirin an Effective Preventive Medicine for Firefighting-Induced Acute Inflammation?"
Topics: Aged; Aspirin; Firefighters; Humans; Inflammation | 2019 |
Modulating Inflammation in Monocytes Using Capillary Fiber Organic Electronic Ion Pumps.
Topics: Aspirin; Cytokines; Drug Delivery Systems; Electrolytes; Electronics; Humans; Hydrogen-Ion Concentra | 2019 |
The potential of acetylsalicylic acid and vitamin E in modulating inflammatory cascades in chickens under lipopolysaccharide-induced inflammation.
Topics: Animal Feed; Animals; Aspirin; Avian Proteins; Chickens; Cytochrome P-450 Enzyme System; Diet; Dieta | 2019 |
Discovery of aspirin-triggered eicosanoid-like mediators in a
Topics: Animals; Aspirin; Drosophila melanogaster; Drosophila Proteins; Eicosanoids; Female; Hematopoietic S | 2019 |
Adaptive in vivo device for theranostics of inflammation: Real-time monitoring of interferon-γ and aspirin.
Topics: Animals; Aptamers, Peptide; Aspirin; Biosensing Techniques; Carbon; Cellular Microenvironment; Elect | 2020 |
Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia.
Topics: Acetylation; Adolescent; Adult; Aspirin; Cell Adhesion; Cyclooxygenase 2; Female; Human Umbilical Ve | 2020 |
Determinants of aspirin resistance in patients with type 2 diabetes.
Topics: Aged; Arachidonic Acid; Aspirin; C-Reactive Protein; Coronary Artery Disease; Diabetes Mellitus, Typ | 2020 |
Urgent to correctly understand the role of aspirin in cardiovascular disease.
Topics: Acute Coronary Syndrome; Aspirin; Cardiovascular Diseases; Humans; Hydroxymethylglutaryl-CoA Reducta | 2020 |
Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.
Topics: Anilides; Animals; Aspirin; Carcinogenesis; Cell Proliferation; Colitis; Colorectal Neoplasms; Disea | 2020 |
Decreased contrast enhancement on high-resolution vessel wall imaging of unruptured intracranial aneurysms in patients taking aspirin.
Topics: Aged; Anterior Cerebral Artery; Aspirin; Basilar Artery; Blood Vessels; Contrast Media; Female; Huma | 2020 |
Aspirin enhances regulatory functional activities of monocytes and downregulates CD16 and CD40 expression in myocardial infarction autoinflammatory disease.
Topics: Anti-Inflammatory Agents; Aspirin; Autoimmune Diseases; Calcium; CD40 Antigens; Cells, Cultured; Cyt | 2020 |
Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Down-Regulation; Hepatic Stellate Cells; | 2020 |
Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model.
Topics: Animals; Animals, Newborn; Aspirin; Brain Ischemia; Clopidogrel; Disease Models, Animal; Inflammatio | 2020 |
Clopidogrel Prophylaxis Abates Myocardial Ischemic Injury and Inhibits the Hyperlipidemia-Inflammation Loop in Hypercholestrolemic Mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Humans; Hypercholesterolemia; Hyperlipidemias | 2020 |
Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Aspirin; Breast; Breast Neoplasms; Cell Different | 2020 |
Influence of kiwifruit on gastric and duodenal inflammation-related gene expression in aspirin-induced gastric mucosal damage in rats.
Topics: Actinidia; Animals; Aspirin; CLOCK Proteins; Duodenum; Fruit; Gastric Mucosa; Gene Expression Regula | 2020 |
Heterogeneity of lower airway inflammation in patients with NSAID-exacerbated respiratory disease.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Biomarkers; Bronchoalveolar L | 2021 |
Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle.
Topics: Animals; Aspirin; Biomarkers; Body Weight; Cattle; Cattle Diseases; Chromium; Diet; Digestion; Femal | 2020 |
Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner.
Topics: Aspirin; Cell Line, Tumor; Gene Expression; Histones; Humans; Inflammation; Methylation; Neoplasms; | 2020 |
Aspirin with or without statin in the treatment of endotheliitis, thrombosis, and ischemia in coronavirus disease.
Topics: Aspirin; Betacoronavirus; Comorbidity; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; En | 2020 |
Specialized Proresolving Mediators Overcome Immune Suppression Induced by Exposure to Secondhand Smoke.
Topics: Animals; Antibodies; Aspirin; Asthma; B-Lymphocytes; Bronchoalveolar Lavage Fluid; Cytokines; Docosa | 2020 |
Effect of acetylsalicylic acid on inflamed adipose tissue. Insulin resistance and hepatic steatosis in a mouse model of diet-induced obesity.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diet, High-Fat; Disease M | 2021 |
Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway.
Topics: Animals; Aspirin; Clopidogrel; Drugs, Chinese Herbal; Inflammation; Interleukin-6; Oxidative Stress; | 2021 |
Dual Ratiometric SERS and Photoacoustic Core-Satellite Nanoprobe for Quantitatively Visualizing Hydrogen Peroxide in Inflammation and Cancer.
Topics: Animals; Aspirin; Breast Neoplasms; Cell Line, Tumor; Female; Gold; Hydrogen Peroxide; Inflammation; | 2021 |
Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia.
Topics: Animals; Aspirin; Chemoprevention; Cholecystolithiasis; Cholesterol; Cholesterol, Dietary; Chronic D | 2020 |
Anti-thrombotic and anti-inflammatory activity of sulodexide compared to aspirin in the rat model.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Disease Models, Animal; Glycosaminoglyca | 2021 |
Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO).
Topics: Anticoagulants; Aspirin; C-Reactive Protein; Gangrene; Heparin, Low-Molecular-Weight; Humans; Inflam | 2021 |
The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Aspirin; Blood Glucose; Diabetes Mel | 2021 |
Aspirin treatment prevents inflammation in experimental bifurcation aneurysms in New Zealand White rabbits.
Topics: Aneurysm; Animals; Aspirin; Disease Models, Animal; Inflammation; Intracranial Aneurysm; Pancreatic | 2022 |
Low-Dose Aspirin Prevents Kidney Damage in LPS-Induced Preeclampsia by Inhibiting the WNT5A and NF-κB Signaling Pathways.
Topics: Animals; Apoptosis; Aspirin; Blood Pressure; Blood Proteins; Cell Line; Cells, Cultured; Disease Mod | 2021 |
ZINC40099027 Promotes Gastric Mucosal Repair in Ongoing Aspirin-Associated Gastric Injury by Activating Focal Adhesion Kinase.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Creatini | 2021 |
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Cytokines; Endothelial Cells; Extracellular Vesicles; Hea | 2021 |
Modulating Mechanical and Shape-Memory Properties while Mitigating Degradation-Induced Inflammation of Polylactides by Pendant Aspirin Incorporation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calorimetry, Differential Scanning; Carbo | 2021 |
Food antigens exacerbate intestinal damage and inflammation following the disruption of the mucosal barrier.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Collagen Type II; Disease Models | 2021 |
The impact of low-dose aspirin on markers of inflammation and placental function: an ancillary study of the ASPIRIN trial.
Topics: alpha-Fetoproteins; Aspirin; Biomarkers; Case-Control Studies; Female; Humans; Inflammation; Placent | 2022 |
Physiologically relevant aspirin concentrations trigger immunostimulatory cytokine production by human leukocytes.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecox | 2021 |
Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease.
Topics: Adult; Animals; Aspirin; Asthma, Aspirin-Induced; Eosinophils; Female; Gene Expression Regulation; G | 2021 |
AT-RvD1 Promotes Resolution of Inflammation in NOD/ShiLtJ mice.
Topics: Animals; Aspirin; Dexamethasone; Docosahexaenoic Acids; Epithelium; Female; Inflammation; Male; Mice | 2017 |
Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumo | 2017 |
Topics: Animals; Aorta; Arachidonic Acid; Aspirin; Cell Adhesion Molecules; DNA, Bacterial; Endothelial Cell | 2017 |
Co-incubation of PMN and CaCo-2 cells modulates inflammatory potential.
Topics: Aspirin; Azepines; Caco-2 Cells; Calcimycin; Humans; Inflammation; N-Formylmethionine Leucyl-Phenyla | 2017 |
[Large vessel vasculitis : pathogenesis, diagnostic and medical management].
Topics: Aspirin; Biological Products; Giant Cell Arteritis; Glucocorticoids; Humans; Inflammation; Takayasu | 2017 |
Associations of Statins and Diabetes with Diagnosis of Ulcerated Cutaneous Melanoma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Sectio | 2017 |
Physiopathology and genetics in aspirin-exacerbated respiratory disease.
Topics: Antigen Presentation; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Genetic Association Studie | 2017 |
Expression of tissue inhibitor of metalloproteinases and matrix metalloproteinases in the ischemic brain of photothrombosis model mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Disease Models, Animal; Endothelia | 2018 |
Artesunate affords protection against aspirin-induced gastric injury by targeting oxidative stress and proinflammatory signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Artemisinins; Artesunate; Aspir | 2018 |
Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke.
Topics: Animals; Aspirin; Behavior, Animal; Benzodioxoles; Brain; Brain Edema; Brain Ischemia; Disease Model | 2018 |
The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chrysobalanaceae; Disease Models, Animal; D | 2018 |
Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease.
Topics: Aspirin; Child; Child, Preschool; Coronary Aneurysm; Coronary Artery Disease; Coronary Vessels; Drug | 2018 |
The Effects of Exercise, Aspirin, and Celecoxib in an Atherogenic Environment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Celecoxib; Cells, Cultured; Epopr | 2018 |
Aspirin Disrupts the Crosstalk of Angiogenic and Inflammatory Cytokines between 4T1 Breast Cancer Cells and Macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Cell Line, Tumor | 2018 |
Melatonin: A hypothesis for Kawasaki disease treatment.
Topics: Anti-Inflammatory Agents; Aspirin; Child; Child, Preschool; Communicable Diseases; Genetic Predispos | 2018 |
Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease.
Topics: Adult; Aspirin; Asthma, Aspirin-Induced; Biomarkers; Cell Line; Computational Biology; Cytokines; Eo | 2018 |
Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation and Inflammation in Kawasaki Disease.
Topics: Aspirin; Biomarkers; Blood Platelets; Blood Sedimentation; C-Reactive Protein; Cell-Derived Micropar | 2019 |
Inflammaging impairs peripheral nerve maintenance and regeneration.
Topics: Aging; Animals; Anti-Inflammatory Agents; Aspirin; Chemokine CCL11; Ganglia, Spinal; Inflammation; M | 2018 |
New drug candidates for depression - a nationwide population-based study.
Topics: Adult; Aged; Allopurinol; Angiotensins; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agen | 2019 |
Pre-existing treatment with aspirin or statins influences clinical presentation, infarct size and inflammation in patients with de novo acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Biomarkers; C-Reactive Protein; Coronary Angiography; Electr | 2019 |
Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Inflammation; Male; Mice; O | 2019 |
Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cytokines; Docosahexae | 2019 |
Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease.
Topics: Adult; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Case-Control Studies; Female; | 2019 |
Effect of anti-inflammatory activity of ranolazine in rat model of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Edema; Granul | 2018 |
Aspirin-triggered proresolving mediators stimulate resolution in cancer.
Topics: Animals; Antineoplastic Agents; Aspirin; Chemokine CCL2; Chemokines; Cytokines; Disease Models, Anim | 2019 |
Nonsteroidal Anti-inflammatory Drugs Modulate Gene Expression of Inflammatory Mediators in Oral Squamous Cell Carcinoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Squamous Cell; Celecoxib; Cell Line, Tu | 2019 |
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aspirin; Biomarkers; Blood Platelets; Cohort Studies; Colorectal Neopla | 2019 |
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Topics: Animals; Aspirin; Cell Movement; Cell Proliferation; Cicatrix; Inflammation; Interleukin-1beta; Male | 2019 |
Is Aspirin an Effective Preventive Medicine for Firefighting-Induced Acute Inflammation?
Topics: Aged; Aspirin; Firefighters; Humans; Inflammation; Physical Exertion | 2019 |
Regulation of the inflammatory response by vascular grafts modified with Aspirin-Triggered Resolvin D1 promotes blood vessel regeneration.
Topics: Animals; Aorta, Abdominal; Aspirin; Blood Vessel Prosthesis; Coated Materials, Biocompatible; Docosa | 2019 |
Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; C-Reactive Protein; Coronary Artery Disease; Cross-Secti | 2013 |
Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.
Topics: Animals; Aspirin; Cytokines; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Humans; Immunosuppressi | 2013 |
Functional imaging of Rel expression in inflammatory processes using bioluminescence imaging system in transgenic mice.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Encephalomyelitis, Autoimmune, Experiment | 2013 |
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Cyclophos | 2013 |
Differential impact of inflammation on six laboratory assays measuring residual arachidonic acid-inducible platelet reactivity during dual antiplatelet therapy.
Topics: Aged; Arachidonic Acids; Aspirin; Blood Platelets; C-Reactive Protein; Electrochemistry; Female; Hum | 2013 |
Non-steroidal anti-inflammatory drugs (NSAIDs).
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; As | 2013 |
[Influence of hypoxen on acetylsalicylic acid efficiency in acute inflammation].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Dose-Response Relationship, | 2013 |
Regulation on RhoA in vascular smooth muscle cells under inflammatory stimulation proposes a novel mechanism mediating the multiple-beneficial action of acetylsalicylic acid.
Topics: Animals; Aspirin; Cell Proliferation; Cell Survival; Cells, Cultured; Enzyme Activation; Inflammatio | 2013 |
Anti-inflammatory effect of auraptene extracted from trifoliate orange (Poncirus trifoliate) on LPS-stimulated RAW 264.7 cells.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cell Line; Coumarins; Cyclooxygenase 2; Dinoprostone; In | 2013 |
Deficient glucocorticoid induction of anti-inflammatory genes in nasal polyp fibroblasts of asthmatic patients with and without aspirin intolerance.
Topics: Aspirin; Asthma, Aspirin-Induced; Drug Resistance; Fibroblasts; Gene Expression Regulation; Glucocor | 2013 |
Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide induced inflammatory response in primary astrocytes.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Aspirin; Astrocytes; Cells, Cultured; Cyclooxyg | 2014 |
Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis.
Topics: AMP-Activated Protein Kinases; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phyto | 2014 |
Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.
Topics: Adoptive Transfer; Ampicillin; Animals; Anti-Bacterial Agents; Aspirin; Candida; Candidiasis; Cefope | 2014 |
The prodrug platin-A: simultaneous release of cisplatin and aspirin.
Topics: Administration, Intravenous; Aspirin; Cisplatin; Humans; Inflammation; Neoplasms; Prodrugs | 2014 |
A prospective study of macrophage inhibitory cytokine-1 (MIC-1/GDF15) and risk of colorectal cancer.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Case-Control Studies; Col | 2014 |
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.
Topics: Animals; Aspirin; Cyclooxygenase 2; Gastric Mucosa; Hydrogen; Inflammation; Interleukin-1beta; Inter | 2014 |
Cytokines and hs-CRP levels in individuals treated with low-dose aspirin for cardiovascular prevention: a population-based study (CoLaus Study).
Topics: Adult; Aged; Aspirin; Body Composition; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases | 2014 |
Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Choline; Cytokines; Drug Synergism; Edema; | 2014 |
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
Topics: Administration, Oral; Angiopoietin-1; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Ex | 2014 |
Impaired resolution of inflammation in human chronic heart failure.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Cardiovascular Diseases; Chronic | 2014 |
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Biomarkers; Chromatography, Liqui | 2014 |
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Biomarkers; Chromatography, Liqui | 2014 |
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Biomarkers; Chromatography, Liqui | 2014 |
Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Biomarkers; Chromatography, Liqui | 2014 |
Low dose aspirin is associated with plasma chemerin levels and may reduce adipose tissue inflammation.
Topics: Adipocytes; Adipose Tissue; Aspirin; Biomarkers; Case-Control Studies; Cell Line; Chemokines; Corona | 2014 |
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-κB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Aspirin; Blotting, West | 2014 |
Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines.
Topics: Aging; Animals; Aspirin; Autacoids; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Unsat | 2014 |
Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis.
Topics: Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cytokines; Heme Oxygenase-1; In | 2014 |
25-Hydroxyvitamin D2 /D3 levels and factors associated with systemic inflammation and melanoma survival in the Leeds Melanoma Cohort.
Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ste | 2015 |
Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Aspirin; Asteraceae; Ban | 2014 |
Aspirin resistance in adult patients after Fontan surgery.
Topics: Adult; Aspirin; CD40 Antigens; Drug Resistance; Endothelium, Vascular; Female; Fontan Procedure; Hea | 2015 |
Two distinct leukotriene B4 receptors, BLT1 and BLT2.
Topics: Animals; Aspirin; CD8-Positive T-Lymphocytes; Cell Movement; Cloning, Molecular; Humans; Immunity, I | 2015 |
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Azoxymethane; Carc | 2015 |
[Aspirin treatment for patients with Kawasaki disease].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Inflammation; Mucocutaneous | 2014 |
Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers: NIH-AARP study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Female; Humans; Incidence; I | 2014 |
Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype.
Topics: Adipokines; Adult; Aspirin; Asthma, Aspirin-Induced; Case-Control Studies; Chitinase-3-Like Protein | 2015 |
Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Aspirin; Cinnamates; Forkhead Box Protein O1; F | 2015 |
Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeic Acids; Eye Diseases; Indomethacin | 2015 |
Aspirin 'resistance': impact on no-reflow, platelet and inflammatory biomarkers in diabetics after ST-segment elevation myocardial infarction.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Diabetes Complications; Drug Resistance; Female; Humans; Inf | 2015 |
Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia.
Topics: Achondroplasia; Animals; Anti-Inflammatory Agents; Antioxidants; Aspirin; Cartilage Oligomeric Matri | 2015 |
Stroke mimicking relapse in a patient with CLIPPERS syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Brain Stem; Encephalomye | 2015 |
Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors.
Topics: Allergens; Animals; Aspirin; Asthma; Blood Platelets; Bone Marrow Transplantation; Bronchoalveolar L | 2015 |
Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.
Topics: Aspirin; Cyclooxygenase 2; HMGB1 Protein; Humans; Inflammation; Mutation; Nuclear Magnetic Resonance | 2015 |
Nonsteroidal Anti-Inflammatory Drug and Aspirin Use, and Mortality among Critically Ill Pandemic H1N1 Influenza Patients: an Exploratory Analysis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Critical Illness; Female; Humans; In | 2016 |
Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma.
Topics: Animals; Anthelmintics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile Duct Neoplasms; Bile | 2016 |
Effects of Acetylsalicylic Acid Usage on Inflammatory and Oxidative Stress Markers in Hemodialysis Patients.
Topics: Antioxidants; Aspirin; Biomarkers; C-Reactive Protein; Female; Glutathione; Humans; Hydrogen Peroxid | 2016 |
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.
Topics: Adaptive Immunity; Animals; Antibodies, Monoclonal; Antigens, CD; Aspirin; Cell Line, Tumor; Dendrit | 2015 |
Inflammation activation and resolution in human tendon disease.
Topics: Adolescent; Adult; Arachidonate 15-Lipoxygenase; Aspirin; Female; Humans; Immunohistochemistry; In V | 2015 |
Treatment of colonic transplantation tumor-bearing mice with a high-dose aspirin in a short period of time.
Topics: Animals; Aspirin; Cell Line, Tumor; Colonic Neoplasms; Cost-Benefit Analysis; Dose-Response Relation | 2016 |
Relationship between Inflammation and Aspirin and Clopidogrel Antiplatelet Responses in Acute Ischemic Stroke.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Brain Ischemia; CD40 Ligand; Clopidogrel; Femal | 2016 |
Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; B7-2 Antigen; Cell Line; Coculture Techni | 2016 |
Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Proliferation; Cyclic AMP; Dinop | 2016 |
Study of oxidative and inflammatory parameters in LDLr-KO mice treated with a hypercholesterolemic diet: Comparison between the use of Campomanesia xanthocarpa and acetylsalicylic acid.
Topics: Animals; Aspirin; Atherosclerosis; Brazil; Hypercholesterolemia; Inflammation; Lipoproteins, LDL; Ma | 2016 |
Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae.
Topics: Animals; Aspirin; Bacterial Load; Cell Movement; Cytokines; Docosahexaenoic Acids; Female; Haemophil | 2016 |
[Protective effect of compound bismuth and magnesium granules on aspirin-induced gastric mucosal injury in rats].
Topics: Animals; Antacids; Aspirin; Bismuth; Gastric Mucosa; Inflammation; Interleukin-1; Interleukin-2; Int | 2016 |
Alterations of soluble TWEAK and CD163 concentrations in patients with chronic heart failure.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspirin; Case-Control Studies; | 2016 |
Phytochemistry, Antinociceptive and Anti-inflammatory Actvities of Methanolic Leaves Extract of Lannea schimperi (Hoschst. Ex Rich) ENG.
Topics: Anacardiaceae; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Inflammation; Methanol; Mice; | 2016 |
Effects of Arnica comp.-Heel® on reducing cardiovascular events in patients with stable coronary disease.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Dr | 2016 |
Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Infla | 2016 |
Drug Targets for Cardiovascular-Safe Anti-Inflammatory: In Silico Rational Drug Studies.
Topics: Anti-Inflammatory Agents; Aspirin; Binding Sites; Caffeic Acids; Celecoxib; Coumaric Acids; Cyclooxy | 2016 |
Prophylactic acetylsalicylic acid attenuates the inflammatory response but fails to protect exercise-induced liver damage in exercised rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspirin; Dose-Response Relationship, Dru | 2016 |
[Effects of aspirin on dendritic cells in the inflammatory microenvironment of rabbit buccal VX-2 squamous cell carcinoma].
Topics: Animals; Aspirin; Carcinoma, Squamous Cell; Coculture Techniques; Dendritic Cells; Flow Cytometry; H | 2016 |
miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40.
Topics: Aspirin; Atherosclerosis; Brain Ischemia; CD40 Antigens; Cell Proliferation; Female; Flow Cytometry; | 2016 |
Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease.
Topics: Aspirin; Cell Line; Cyclooxygenase Inhibitors; Humans; Inflammation; Interleukin-4; Respiration Diso | 2016 |
Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Epithelial-Mesenchymal | 2016 |
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo | 2016 |
AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Combined Modality Therapy; Dexamethasone; | 2016 |
From "Samter's Triad" to "NERD": The Long and Winding Road to Understanding Aspirin-Exacerbated Respiratory Disease.
Topics: Allergens; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Cyclooxygenase | 2016 |
Aspirin-Exacerbated Respiratory Disease: The Hunt for the "Rosetta Stone" of Respiratory Inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Humans; Inflammation; Mol | 2016 |
Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biocompatible Materials; Bone Marrow Cell | 2016 |
Aspirin down Regulates Hepcidin by Inhibiting NF-κB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide.
Topics: Animals; Aspirin; Cell Line; Hepcidins; Inflammation; Interleukin-6; Iron Regulatory Protein 1; Janu | 2016 |
Investigations on anti-inflammatory and analgesic activities of Alnus nitida Spach (Endl). stem bark in Sprague Dawley rats.
Topics: Alnus; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Chromatography, High Pressure Liquid; | 2017 |
Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice.
Topics: Acinar Cells; Animals; Apoptosis; Aspirin; bcl-2-Associated X Protein; Caspase 3; Cell Nucleus; Down | 2016 |
Aspirin-Triggered Resolvin D1-modified materials promote the accumulation of pro-regenerative immune cell subsets and enhance vascular remodeling.
Topics: Animals; Aspirin; Biocompatible Materials; Cytokines; Docosahexaenoic Acids; Drug Delivery Systems; | 2017 |
[Nonallergic diseases of the upper and lower airways].
Topics: Aspirin; Asthma; Bronchitis; Diagnosis, Differential; Drug Hypersensitivity; Eosinophilia; Humans; I | 2008 |
Involvement of subcellular organelles in inflammatory pain-induced oxidative stress and apoptosis in the rat hepatocytes.
Topics: Animals; Apoptosis; Aspirin; Celecoxib; Hepatocytes; Inflammation; Male; Organelles; Oxidative Stres | 2008 |
Enhancement of anti-inflammatory property of aspirin in mice by a nano-emulsion preparation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Croton Oil; Disease Models, Animal; Drug | 2008 |
Inhibition of chemically induced inflammation and pain by orally and topically administered leaf extract of Manihot esculenta Crantz in rodents.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Aspi | 2008 |
Influence of protein malnutrition on induction and treatment of inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Diclofenac; Diet, Protein-Re | 2006 |
The antinociceptive efficacy of morphine, metamizol, or their combination in an experimental rat model with different levels of inflammatory pain.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dipyrone; Dose-Respon | 2008 |
Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats.
Topics: Amino Acids; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Aspiri | 2008 |
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cannabinoid Receptor Modula | 2008 |
A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects.
Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Dinoprost; Dinoprostone; | 2009 |
Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygena | 2007 |
Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Atherosclerosis; Benzofurans; Cells, Cultured; Cyclooxygenase | 2009 |
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Aspirin; Carrier Proteins; Caspase Inhi | 2009 |
Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model.
Topics: Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Drug Toler | 2009 |
The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy.
Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gene Expression Profiling; | 2009 |
Tumor markers and rectal cancer: support for an inflammation-related pathway.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biomarkers, Tumor; Cali | 2009 |
The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Comorbidity; Drug Resistance; Electrocardi | 2009 |
Theophylline again? Reasons for believing.
Topics: Anti-Inflammatory Agents; Aspirin; Asthma; Bronchodilator Agents; Humans; Inflammation; Phosphoric D | 2009 |
Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Aspirin; Chalcone; Dose-Response | 2009 |
Antagonistic effects of aspirin and folic acid on inflammation markers and subsequent risk of recurrent colorectal adenomas.
Topics: Adenoma; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Col | 2009 |
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Asp | 2010 |
Clopidogrel for the hot patient.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; C-Reactive Protein; Clopidogrel; Drug Therapy, | 2009 |
Relationship between baseline inflammatory markers, antiplatelet therapy, and adverse cardiac events after percutaneous coronary intervention: an analysis from the clopidogrel for the reduction of events during observation trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; C-Reactive Protein; Clopidogrel; Double-B | 2009 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin | 2010 |
Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; ATP Binding Cassette Tra | 2010 |
Novel conjugates of aspirin with phenolic acid as anti-inflammatory agents having significantly reduced gastrointestinal toxicity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aspirin; Biphenyl Compounds; Croton Oil; Disease Mo | 2010 |
Combination of aspirin with telmisartan suppresses the augmented TGFbeta/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2010 |
Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1alpha in macrophages during aspirin-induced mesenteric inflammation.
Topics: Animals; Aspirin; Enzyme Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry | 2010 |
Impaired anti-platelet effect of aspirin, inflammation and platelet turnover in cardiac surgery.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Coronary Artery Bypass; Female; Humans; Inflammation; In | 2010 |
Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung.
Topics: Adenosine; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Disease Mod | 2010 |
Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis.
Topics: Animals; Aspirin; Body Weight; Fermentation; Gastric Mucosa; Gastritis; Inflammation; Interferon-gam | 2010 |
Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Glucose; C-Reactive Protein; Clopid | 2010 |
Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Biomarkers; Boronic Acids; | 2010 |
Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon; Aspirin; Blood Platelets; C-Reactive Protein; C | 2010 |
Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway.
Topics: Animals; Apoptosis; Aspirin; bcl-X Protein; Body Weight; Colorectal Neoplasms; Disease Models, Anima | 2011 |
Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Hemodynamics; Inflammation; | 2011 |
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygena | 2011 |
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygena | 2011 |
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygena | 2011 |
Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Aspirin; Cyclooxygena | 2011 |
1-Phenyl-6,7-dihydroxy-isochroman suppresses lipopolysaccharide-induced pro-inflammatory mediator production in human monocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Chromans; Cyclooxygenase 2; Dinoprosto | 2011 |
Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment.
Topics: Animals; Apoptosis; Aspirin; Brain; Disease Models, Animal; Female; Gene Expression Profiling; Gene | 2011 |
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem | 2011 |
Chemoprevention: First line of defence.
Topics: Animals; Aspirin; Celecoxib; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Cyclooxygenase I | 2011 |
Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cell Movement; Chromatography, Liquid; Docosahexaenoic A | 2011 |
Effects of platelet and inflammatory system activation on outcomes in diabetic patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Diabetes Complicati | 2011 |
Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Enzyme Activation; Inflammatio | 2011 |
High frequency of aspirin resistance in patients with nephrotic syndrome.
Topics: Adolescent; Adult; Aged; Aspirin; Biomarkers; Female; Follow-Up Studies; Humans; Inflammation; Male; | 2012 |
A girl with extremely refractory Kawasaki disease: an instructive case with unusual course and outcome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Coronary Aneurysm; Echocardiography; Fatal Outcome | 2012 |
Differential inhibitory potencies of alcoholic extract of different parts of Dryopteris chrysocoma on inflammation in mice and rats.
Topics: Animals; Aspirin; Carrageenan; Dryopteris; Edema; Ethanol; Female; Formaldehyde; Inflammation; Male; | 2011 |
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.
Topics: Administration, Oral; Animals; Apoptosis Regulatory Proteins; Aspirin; Biocompatible Materials; Calc | 2011 |
Acute phase inflammatory markers in patients with non-steroidal anti-inflammatory drugs (NSAIDs)-induced acute urticaria/angioedema and after aspirin challenge.
Topics: Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-React | 2013 |
Acute phase inflammatory markers in patients with non-steroidal anti-inflammatory drugs (NSAIDs)-induced acute urticaria/angioedema and after aspirin challenge.
Topics: Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-React | 2013 |
Acute phase inflammatory markers in patients with non-steroidal anti-inflammatory drugs (NSAIDs)-induced acute urticaria/angioedema and after aspirin challenge.
Topics: Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-React | 2013 |
Acute phase inflammatory markers in patients with non-steroidal anti-inflammatory drugs (NSAIDs)-induced acute urticaria/angioedema and after aspirin challenge.
Topics: Adolescent; Adult; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-React | 2013 |
The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Aspirin; Behavio | 2010 |
Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury.
Topics: Acute Lung Injury; Adaptor Proteins, Signal Transducing; Airway Resistance; Animals; Anti-Inflammato | 2013 |
Platelets directly enhance neutrophil transmigration in response to oxidised low-density lipoprotein.
Topics: Aspirin; Atherosclerosis; Blood Platelets; CD11b Antigen; Cell Aggregation; Cell Communication; Cell | 2012 |
Editorial comment: Reduction of oxidative stress: a new indication for acetylsalicylic acid in coronary artery bypass surgery.
Topics: Aspirin; Coronary Artery Bypass; Female; Humans; Inflammation; Male; Oxidative Stress | 2013 |
Oral antigens induce rheumatoid arthritis-like inflammation in a rat model.
Topics: Administration, Oral; Animals; Antigen-Antibody Complex; Antigens; Arthritis, Rheumatoid; Aspirin; C | 2013 |
Body mass index predicts failure of surgical management in benign prostatic hyperplasia.
Topics: Aged; Aspirin; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; | 2013 |
The impact of triple anti-platelet therapy for endothelialization and inflammatory response at overlapping bioabsorbable polymer coated drug-eluting stents in a porcine coronary model.
Topics: Absorbable Implants; Animals; Aspirin; Cilostazol; Clopidogrel; Coated Materials, Biocompatible; Cor | 2013 |
Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma.
Topics: Animals; Aspirin; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dendritic Cells | 2013 |
Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin.
Topics: Anti-Inflammatory Agents; Aspirin; Cells, Cultured; Docosahexaenoic Acids; Glutathione; Humans; Infl | 2013 |
Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis.
Topics: Animals; Apolipoproteins E; Apoptosis; Aspirin; Cholesterol; Disease Models, Animal; Femoral Artery; | 2002 |
Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo.
Topics: Anti-Inflammatory Agents; Apoptosis; Aspirin; Bone Marrow; Cells, Cultured; Cyclic AMP; Drug Stabili | 2002 |
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
Topics: Animals; Aspirin; Biological Factors; Fatty Acids, Omega-3; Humans; Inflammation; Mice; Signal Trans | 2002 |
Aspirin with bypass surgery--from taboo to new standard of care.
Topics: Aspirin; Coronary Artery Bypass; Coronary Disease; Drug Administration Schedule; Humans; Inflammatio | 2002 |
An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Ce | 2002 |
Effect of Helicobacter pylori-mediated inflammation on nonsteroidal anti-inflammatory drugs-induced gastric mucosal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; CD11b Antigen; CD18 Antigens; Cell Adhesi | 2002 |
The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-St | 2003 |
Lipoxins and aspirin-triggered lipoxins in airway responses.
Topics: Animals; Aspirin; Bronchi; Bronchial Hyperreactivity; Humans; Hydroxyeicosatetraenoic Acids; Inflamm | 2003 |
Inflammation in atherosclerosis: causal or casual? The need for randomized trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Humans; Inflammation; Randomized | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Studies on novel 7-acyl-5-chloro-2-oxo-3H-benzoxazole derivatives as potential analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoxazoles; Capillary Perme | 2003 |
[Contributions to evaluation of the substances inhibiting inflammation].
Topics: Aminopyrine; Aspirin; Inflammation; Phenylbutazone; Quinolines; Salicylates | 1963 |
RADIOMETRIC QUANTITATION OF THE INHIBITION OF 5-HYDROXYTRYPTAMINE- INDUCED EDEMA IN MICE.
Topics: Animals; Ascorbic Acid; Aspirin; Cyproheptadine; Edema; Flavonoids; Inflammation; Mice; Phenylbutazo | 1963 |
A THREE-STAGE SEQUENTIAL SCREENING PROGRAM FOR THE DETECTION OF ANTI-INFLAMMATORY AGENTS USING A CARRAGEENIN-INDUCED ABSCESS.
Topics: Abscess; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Aspirin; Biol | 1963 |
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.
Topics: Acetates; Adrenalectomy; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents | 1963 |
EFFECTS OF ACETYLSALICYLIC ACID ON THE EDEMA AND HYPERESTHESIA OF THE EXPERIMENTALLY INFLAMED RAT'S PAW.
Topics: Aspirin; Edema; Hyperesthesia; Inflammation; Leg; Pharmacology; Rats; Research; Saccharomyces | 1963 |
ANTIINFLAMMATORY POTENCY OF 2-(BETA-CHLOROETHYL)-2,3-DIHYDRO-4-OXO-6-AMINO-(BENZ-1,3-OXAZINE) HCL(A350), PHENYLBUTAZONE AND ACETYLSALICYLIC ACID IN CARRAGEENIN-INDUCED EDEMA.
Topics: Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Inflammation; Leg; Oxazines; Pharmacology; Ph | 1964 |
CONSERVATIVE TREATMENT OF A LARGE RADICULAR CYST OF THE MANDIBLE IN A PATIENT WITH SEVERE HEMOPHILIA. REPORT OF A CASE.
Topics: Aspirin; Blood Chemical Analysis; Blood Transfusion; Dentigerous Cyst; Diagnosis, Differential; Drai | 1964 |
[PHARMACOLOGICAL STUDY OF TH-2152].
Topics: Analgesia; Aspirin; Bicarbonates; Bradykinin; Dogs; Fever; Gastric Mucosa; Inflammation; Pain; Pharm | 1964 |
EXPERIMENTAL EVALUATION IN LABORATORY ANIMALS OF ANTI-INFLAMMATORY ANALGESIC DRUGS.
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Animals, Laboratory; Anti-Inflammatory A | 1963 |
[COMPARATIVE ANTIPHLOGISTIC ACTIVITY OF DERIVATIVES OF ANTIMALARIALS].
Topics: Aminopyrine; Anti-Inflammatory Agents; Antimalarials; Aspirin; Edema; Inflammation; Mice; Pharmacolo | 1963 |
[EXPERIMENTAL INFLAMMATION INDUCED BY A HEPARIN ANALOG. A TEST OF ANTI-INFLAMMATORY ACTIVITY].
Topics: Amodiaquine; Anti-Allergic Agents; Anti-Inflammatory Agents; Aspirin; Chemistry, Pharmaceutical; Col | 1964 |
ANTI-INFLAMMATORY AND ANTIPYRETIC PROPERTIES OF N-(2,6-DICHLORO-M-TOLYL)ANTHRANILIC ACID (CI-583).
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Aspirin; | 1965 |
Influence of systemic inflammation on efficiency of antiplatelet therapy in PAOD patients.
Topics: Arterial Occlusive Diseases; Aspirin; C-Reactive Protein; Female; Humans; Inflammation; Male; Periph | 2004 |
Effects of various analgesics on inflammatory edema resulting from silver nitrate injection.
Topics: Analgesics; Aspirin; Edema; Humans; Inflammation; Injections; Silver Nitrate | 1951 |
[Migraine, inflammation, genes. New risk factors for stroke].
Topics: Adult; Arteriosclerosis; Aspirin; C-Reactive Protein; Case-Control Studies; Contraceptives, Oral; Fe | 2003 |
Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population.
Topics: Aged; alpha-Tocopherol; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Blood Glucose; | 2004 |
C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.
Topics: Acute-Phase Reaction; Aspirin; Atorvastatin; Biomarkers; C-Reactive Protein; Cardiovascular Diseases | 2004 |
Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus: relationships to cardiovascular disease and risk factor intervention.
Topics: Aged; Aspirin; Biomarkers; Blood Coagulation; Cardiovascular Diseases; CD40 Ligand; Cohort Studies; | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Endothe | 2004 |
Inhibition of COX pathway in experimental myocardial infarction.
Topics: Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease | 2004 |
Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asp | 2004 |
Supramolecular assemblies based on copolymers of PEG600 and functionalized aromatic diesters for drug delivery applications.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemistry, Pharmaceutical; Drug Delivery | 2004 |
Is the antiplatelet effect of aspirin affected by systemic inflammation?
Topics: Arterial Occlusive Diseases; Aspirin; Blood Platelets; Drug Resistance; Humans; Inflammation; Platel | 2004 |
New xanthone derivatives as potent anti-inflammatory agents.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrage | 2005 |
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D | 2005 |
Antinociceptive properties of ethanolic extract and fractions of Pterodon pubescens Benth. seeds.
Topics: Abdomen; Administration, Oral; Analgesics; Animals; Aspirin; Chemical Fractionation; Dipyrone; Diter | 2005 |
Antinociceptive effects of choline against acute and inflammatory pain.
Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm | 2005 |
Minor inflammation after surgical evacuation compared with fibrinolytic therapy of experimental intracerebral hemorrhages.
Topics: Analysis of Variance; Animals; Aspirin; Blood Transfusion, Autologous; Cerebral Hemorrhage; Confiden | 2005 |
Inflammation, atherosclerosis, and coronary artery disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C-Reactive Protein; Coronary Disease; Humans; Infl | 2005 |
Inflammatory response after intervention assessed by serial C-reactive protein measurements correlates with restenosis in patients treated with coronary stenting.
Topics: Abciximab; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Mono | 2005 |
Influence of systemic inflammation on the interpretation of response to antiplatelet therapy, monitored by PFA-100.
Topics: Arterial Occlusive Diseases; Aspirin; C-Reactive Protein; Collagen; Diffusion; Drug Monitoring; Epin | 2005 |
[Lipoxins--new view on old mediators carrying potent anti-inflammatory action].
Topics: Anti-Inflammatory Agents; Aspirin; Humans; Inflammation; Lipoxins | 2005 |
Comparative appraisal of clodronate, aspirin and dexamethasone as agents reducing alendronate-induced inflammation in a murine model.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Aspirin; Bone Density Conservation Agents; Clodronic | 2005 |
Therapeutic significance of aspirin mediated lipoxin biosynthesis in attenuation of chronic inflammation.
Topics: Aspirin; Chronic Disease; Humans; Inflammation; Lipoxins | 2006 |
Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 2; Cycloo | 2005 |
Effect of short-term, low dose aspirin supplementation on the activation of pro-inflammatory NF-kappaB in aged rats.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gene Expression Regulation; Inflam | 2006 |
Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cy | 2005 |
Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug.
Topics: Abdominal Pain; Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Basic Helix-Loop-Helix Transcription Fact | 2006 |
Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Chronic Disease; Drug Hyperse | 2006 |
Rebound inflammation and the risk of ischemic stroke after discontinuation of aspirin therapy.
Topics: Aspirin; Brain Ischemia; C-Reactive Protein; Humans; Inflammation; Platelet Aggregation Inhibitors; | 2006 |
Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus; Fema | 2006 |
Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; C-Reactive Protein; Cholesterol; | 2006 |
Circulating autoantibodies in patients with aspirin-intolerant asthma: an epiphenomenon related to airway inflammation.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Autoantibodies; Bronchi; Case-Contro | 2006 |
Unveiling the inflammatory face of antiplatelet drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Di | 2006 |
Viscosity, hemostasis and inflammation in atherosclerotic heart diseases.
Topics: Aged; Aspirin; Blood Viscosity; Brain Ischemia; Clopidogrel; Coronary Artery Disease; Diabetes Compl | 2006 |
Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation.
Topics: Animals; Aspirin; Cell Adhesion; Cell Movement; Endothelium, Vascular; Hydrogen Sulfide; Inflammatio | 2006 |
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Elect | 2006 |
[Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology].
Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chorionic Villi; D | 2006 |
Kawasaki-like syndrome possibly associated with immune reconstitution inflammatory syndrome in an HIV-positive patient.
Topics: Anti-HIV Agents; Aspirin; Drug Therapy, Combination; HIV Infections; Humans; Immune System Diseases; | 2006 |
Lymphatic regeneration across an incisional wound: inhibition by dexamethasone and aspirin, and acceleration by a micronized purified flavonoid fraction.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Dextrans; Evans Blue; Flavonoids; Indicat | 2006 |
Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model.
Topics: Animals; Aspirin; Atherosclerosis; Atorvastatin; Chemokine CCL2; Clopidogrel; Diet, Atherogenic; Dis | 2007 |
Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Disease Models, Animal; Dose-Resp | 2007 |
Antinociceptive and antiarthritic activity of Cissampelos pareira roots.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Cissampelos; Dexamethasone; Disea | 2007 |
Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing.
Topics: Animals; Aspirin; Astrocytes; Blotting, Western; Carrageenan; Hyperalgesia; Immunohistochemistry; In | 2007 |
Testing and typing of eicosanoid-patterns.
Topics: Adult; Aged; Analgesics; Arachidonic Acid; Aspirin; Dinoprostone; Eicosanoids; Female; Humans; Infla | 2006 |
Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Death; Diabete | 2007 |
Moderation of the platelet releasate response by aspirin.
Topics: Aspirin; Blood Platelets; Collagen; Cytokines; Gene Expression Regulation; Humans; Immunoenzyme Tech | 2007 |
Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2007 |
Prevalence and biologic profile of aspirin resistance in patients with angiographically proven coronary artery disease.
Topics: Aged; Apolipoproteins B; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Resistance; Epineph | 2007 |
Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Carrageenan; Dinopr | 2008 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
[Experimental research on anti-inflammatory effects of Fu' an oral liquid].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capillary Permeabil | 2007 |
The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin.
Topics: Adenosine Diphosphate; Adult; Aspirin; Biomarkers; Blood Cells; Calcium; Cells, Cultured; Female; Hu | 2007 |
IL6 genotypes and colon and rectal cancer.
Topics: Adult; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Female; G | 2007 |
4'-Acetamidochalcone derivatives as potential antinociceptive agents.
Topics: Acetamides; Acetaminophen; Analgesics; Animals; Aspirin; Chalcone; Chalcones; Chromatography, Thin L | 2007 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Effects of aspirin on the development of Helicobacter pylori-induced gastric inflammation and heterotopic proliferative glands in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aspirin; Choristoma; Dinoprostone; Epithelial Cells; G | 2008 |
Anti-inflammatory effects of combined treatment with acetyl salicylic acid and atorvastatin in haemodialysis patients affected by Normal Weight Obese syndrome.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Atorvastati | 2008 |
Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection.
Topics: Adult; Aspirin; Cell Line, Tumor; Cytokines; Female; Humans; Inflammation; Influenza A virus; Interl | 2008 |
Presence of a general irritation and inhibition of a local inflammation.
Topics: Acetates; Animals; Aspirin; Blood; Carrageenan; Coloring Agents; Edema; Female; Formaldehyde; Hypert | 1966 |
The pharmacology of 2,3-bis-(p-methoxyphenyl)-indole (indoxole).
Topics: Adrenalectomy; Anaphylaxis; Animals; Arthritis; Arthritis, Rheumatoid; Aspirin; Barbiturates; Edema; | 1967 |
[Recent discoveries in the field of mediators of anti-inflammation: leukotrienes].
Topics: 5,8,11,14-Eicosatetraynoic Acid; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arachidonic Aci | 1984 |
How are prostaglandins and leukotrienes involved in immunological alterations?
Topics: Animals; Arachidonic Acids; Aspirin; Burns; Cell Membrane Permeability; Dinoprostone; Eosinophils; F | 1984 |
Aspirin or paracetamol?
Topics: Acetaminophen; Aspirin; Humans; Inflammation | 1981 |
Aspirin or paracetamol?
Topics: Acetaminophen; Aspirin; Humans; Inflammation | 1981 |
The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Asp | 1983 |
Contribution of LTB4 to leukocyte migration in inflammatory lesions.
Topics: Aspirin; Cell Movement; Humans; In Vitro Techniques; Inflammation; Leukocytes; Leukotriene B4 | 1984 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoproston | 1984 |
Fenflumizole: interactions with the arachidonic acid cascade.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Cyclooxygenase Inhibitors; Dinoproston | 1983 |
Dual inhibition of cyclooxygenase and lipoxygenase by 2-acetylthiophene 2-thiazolylhydrazone (CBS-1108) and effect on leukocyte migration in vivo.
Topics: Animals; Arachidonate Lipoxygenases; Aspirin; Blood Platelets; Carboxymethylcellulose Sodium; Chemot | 1984 |
Aggregation of bovine platelets by acetyl glyceryl ether phosphorylcholine (platelet activating factor).
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; In Vitro Techniques; Inflammation; Pl | 1984 |
Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aspirin; Carrageenan; Cycloox | 1984 |
Characteristics and effect of antiinflammatory drugs on adriamycin-induced inflammation in the mouse paw.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Diphenhydramine; Doxorubicin; Fe | 1980 |
Blockade by anti-glucocorticoids, actinomycin D and cycloheximide of the anti-inflammatory action of some Kampohozai (Chinese traditional medicines) against serotonin.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cycloheximide; Dactinomycin; Dexamethasone; Drugs, Chine | 1984 |
[Importance of the knowledge of prostaglandins for the odonto-stomatologist; their role in primary hemostasis and in inflammation].
Topics: Anti-Inflammatory Agents; Anticoagulants; Aspirin; Biochemical Phenomena; Biochemistry; Hemostasis; | 1984 |
The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Chronic Disease; Concanavalin A; Female; Go | 1982 |
Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug | 1983 |
Aspirin update!
Topics: Aspirin; Humans; Inflammation; Pain | 1980 |
Aspirin update!
Topics: Aspirin; Fever; Humans; Inflammation; Pain | 1981 |
The influence of acetylsalicylic acid, phenylbutazone, indomethacin, and flufenamic acid on the kinetics of leucocytes during acute inflammation.
Topics: Analgesics; Animals; Aspirin; Cell Movement; Flufenamic Acid; Indomethacin; Inflammation; Kinetics; | 1980 |
[Comparison of the effect of 3-amino-4-mercapto-6-methylpyridazine with various antiphlogistic agents in rat models of inflammation].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Di | 1982 |
Vascular responses during acute neutrophilic inflammation. Their relationship to in vivo neutrophil emigration.
Topics: Animals; Aspirin; Capillary Permeability; Cell Movement; Chemotactic Factors; Escherichia coli; Hype | 1981 |
The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation.
Topics: Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Dinoprostone; Escherichia coli Infections | 1982 |
Effect of nonsteroidal anti-inflammatory agents on immune complex- and chemotactic factor-induced inflammation.
Topics: Animals; Antigen-Antibody Complex; Aspirin; Chemotactic Factors; Dose-Response Relationship, Drug; D | 1982 |
[Endogenous mediators in the acute local inflammatory process. Anti-inflammatory agents].
Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Aspirin; Humans; Inflammation; Pro | 1982 |
[Pain and its management with drugs].
Topics: Acute Disease; Analgesics; Aspirin; Chronic Disease; Humans; Inflammation; Pain; Prostaglandin Antag | 1982 |
Total serum copper and ceruloplasmin levels following administration of copper aspirinate to rats and guinea-pigs.
Topics: Animals; Aspirin; Ceruloplasmin; Copper; Dose-Response Relationship, Drug; Female; Guinea Pigs; Infl | 1980 |
The modulation of inflammation by the acute phase reaction in adjuvant arthritis in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Blood Proteins; Blood Sedimentation; Dexametha | 1981 |
Seasonal variation in drug action and animal responses in models of inflammation.
Topics: Anaphylaxis; Animals; Aspirin; Cell Movement; Dextrans; Drug Resistance; Glucose; Inflammation; Leuk | 1980 |
Blockade by antiglucocorticoids, actinomycin D and cycloheximide of anti-inflammatory action of dexamethasone against bradykinin.
Topics: Androstenedione; Animals; Aspirin; Bradykinin; Cell Membrane Permeability; Cycloheximide; Dactinomyc | 1980 |
Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy.
Topics: Animals; Aspirin; Butylated Hydroxytoluene; Carrageenan; Disease Models, Animal; Imidazoles; Inflamm | 1980 |
The mechanism of the physiological action of bromelain.
Topics: Aspirin; Bromelains; Fibrinolysis; Humans; Inflammation; Models, Biological; Prostaglandins; Stimula | 1980 |
Synthesis and anti-inflammatory activity of certain new N,N'-oxamides.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Aspirin; Female; Histamine; Inflammation; Lethal Dos | 1980 |
Influence of anti-inflammatory treatments on experimental infection of rats with Fasciola hepatica: changes in serum levels of inflammatory markers during the early stages of fasciolosis.
Topics: Acute-Phase Proteins; Analysis of Variance; Animals; Antibodies, Helminth; Antibody Formation; Antig | 1994 |
Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Aspirin; Cell Adhesion; Cell Adhesion Molecul | 1995 |
Aspirin and inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cyclooxygenase Inhibitors; | 1995 |
Aspirin-induced, neutrophil-mediated injury to vascular endothelium.
Topics: Adult; Antibodies, Monoclonal; Aspirin; Catalase; Cell Adhesion; Cell Size; Cells, Cultured; Cephalo | 1995 |
Induction of oxidative DNA damage and early lesions in rat gastro-intestinal epithelium in relation to prostaglandin H synthase-mediated metabolism of butylated hydroxyanisole.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Aspirin; Biotransformation; Butylated Hydroxyanisole; Cell Div | 1995 |
Antinociceptive and antipyretic effects of alkaloids extracted from the stem bark of Hunteria zeylanica.
Topics: Acetates; Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Non-Narcotic; Animal | 1994 |
Involvement of leukotrienes in allergic inflammation in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Salicylate intoxication causing a severe systemic inflammatory response and rhabdomyolysis.
Topics: Aspirin; Female; Humans; Inflammation; Middle Aged; Multiple Organ Failure; Rhabdomyolysis | 1994 |
Towards a better aspirin.
Topics: Aspirin; Binding Sites; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Inflammation; Isoenzymes | 1994 |
[Atherosclerosis also caused by local vascular inflammation].
Topics: Arteriosclerosis; Aspirin; Endothelium, Vascular; Humans; Inflammation | 1994 |
Further evidence for the involvement of SmI cortical neurons in nociception: their responsiveness at 24 hr after carrageenin-induced hyperalgesic inflammation in the rat.
Topics: Animals; Aspirin; Brain Mapping; Carrageenan; Dominance, Cerebral; Evoked Potentials, Somatosensory; | 1993 |
Nasal secretions in response to acetylsalicylic acid.
Topics: Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; Inflammation; Male; Middle Aged | 1993 |
[Pharmacology of anti-migraine drugs].
Topics: Aspirin; Ergotamine; Headache; Humans; Inflammation; Mental Disorders; Muscle Contraction; Neuralgia | 1993 |
Enhancement of anti-inflammatory activity of aspirin by verapamil.
Topics: Adrenal Glands; Animals; Aspirin; Carrageenan; Drug Synergism; Female; Foreign Bodies; Inflammation; | 1993 |
Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects.
Topics: Administration, Inhalation; Administration, Oral; Administration, Topical; Adrenal Cortex Hormones; | 1996 |
Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Analysis of Variance; Animals; Aspirin; Body Temperature; Diseas | 1996 |
Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1995 |
Synthesis and anti-inflammatory properties of 8-(3-dimethylaminopropionyl)-1,6-benzodioxocane.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bri | 1995 |
Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Sequence; Chemo | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease.
Topics: Aspirin; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Humans; Inflammation | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease.
Topics: Aspirin; Blood Coagulation; C-Reactive Protein; Cardiovascular Diseases; Humans; Inflammation | 1997 |
Inflammation, aspirin, and the risk of cardiovascular disease.
Topics: Aspirin; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Humans; Inflammation | 1997 |
Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Connective tissue activation. XXXVII. Effects of cytokine combinations, implications for an integrated cytokine network.
Topics: Arthritis, Rheumatoid; Aspirin; Cells, Cultured; Connective Tissue; Culture Media, Conditioned; Cyto | 1997 |
A chelate theory for the mechanism of action of aspirin-like drugs.
Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calc | 1998 |
Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cycloo | 1999 |
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.
Topics: Adenosine Deaminase; Animals; Aspirin; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Female; Gluc | 1999 |
Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemokine CXCL2; Chemokines; Cytokines; G | 1999 |
Sites of action for future therapy: an adenosine-dependent mechanism by which aspirin retains its antiinflammatory activity in cyclooxygenase-2 and NFkappaB knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Inflammation; | 1999 |
Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Biopsy, Needle; Capill | 2000 |
Systemic anti-inflammation by synthetic interleukin-1 blockers.
Topics: Acridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Imines; Inflammation; | 1999 |
Local and systemic delivery of an aspirin-triggered lipoxin stable analog inhibits neutrophil trafficking.
Topics: Animals; Aspirin; Cell Movement; Drug Carriers; Hydroxyeicosatetraenoic Acids; Inflammation; Lipoxin | 2000 |
Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.
Topics: Acyl Coenzyme A; Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2000 |
Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries.
Topics: Arteriosclerosis; Aspirin; Biopsy; Carotid Artery Diseases; Case-Control Studies; Cyclooxygenase 1; | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
How hot is inflammation in acute coronary syndrome?
Topics: Angina, Unstable; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corona | 2000 |
Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.
Topics: Animals; Aspirin; Binding, Competitive; Capillary Permeability; Cell Line; COS Cells; Dose-Response | 2001 |
Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; C-Reactive Protei | 2001 |
Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoates; Cell Death; | 2001 |
Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis.
Topics: Aged; Arteriosclerosis; Ascorbic Acid; Aspirin; C-Reactive Protein; Female; Fibrinogen; Humans; Hype | 2001 |
Blood polymorphonuclear leukocyte activation in atherosclerosis: effects of aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Case-Control Studies; Chemotaxis | 2001 |
Exercise-induced inflammatory reaction affects electromyographic changes in skeletal muscle during dynamic contractions in humans.
Topics: Action Potentials; Adult; Analysis of Variance; Aspirin; Cyclooxygenase Inhibitors; Electromyography | 2001 |
Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain.
Topics: Animals; Aspirin; Avoidance Learning; Carrageenan; Dose-Response Relationship, Drug; Escape Reaction | 2001 |
Pioglitazone, a specific PPAR-gamma ligand, inhibits aspirin-induced gastric mucosal injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; DNA Primers; Enzyme-Linked Immunosorbent | 2001 |
A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis.
Topics: Animals; Arthritis, Experimental; Aspartame; Aspirin; Behavior, Animal; Carrageenan; Dose-Response R | 2001 |
The future of hormesis: what is the clinical relevance to hormesis?
Topics: Adaptation, Physiological; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cadmium; Cen | 2001 |
High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Cardiovascular Dis | 2001 |
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspirin; Blood Pressure; Brain; Brain Is | 2002 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2001 |
Cardiovascular disease. Does inflammation cut to the heart of the matter?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Biological Evol | 2002 |
Atherosclerosis: the new view.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Arterie | 2002 |
Endogenous salicylates, aspirin, and inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Humans; Inflammati | 2002 |
Concerning the merits of copper aspirin as a potential anti-inflammatory drug.
Topics: Animals; Aspirin; Copper; Gastric Mucosa; Inflammation; Irritants; Male; Rats; Time Factors | 1976 |
[Anti-inflammatory and analgesic effects of eterilate, benorylate and acetylsalicylic acid].
Topics: Acetanilides; Animals; Anti-Inflammatory Agents; Aspirin; Female; Inflammation; Male; Mice; Pain; Ra | 1978 |
Salicylate blockade of granulocyte adherence and the inflammatory response to experimental peritonitis.
Topics: Animals; Aspirin; Cell Adhesion; Endotoxins; Escherichia coli; Female; Granulocytes; Humans; Inflamm | 1979 |
The role of the acute phase reaction in inflammation.
Topics: alpha-Macroglobulins; Animals; Arthritis, Rheumatoid; Aspirin; Inflammation; Male; Orosomucoid; Prot | 1976 |
The mode of action of aspirin-like drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyclooxygenase Inhibitors; Humans; Inflammation; Prostag | 1978 |
(N-Barbituryl)phenyl- and cyclohexylalkanoic acids and some of their derivatives as potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Barbiturates; Carboxylic Acids; Cyclooxygenase Inhibitor | 1978 |
Anti-inflammatory activity of thiabendazole and its relation to parasitic disease.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Dogs; Dracunculiasis; Female; Fe | 1975 |
On the enzymatic response to injury and its mediators.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Burns; | 1979 |
Prostaglandin release from human polymorphonuclear leukocytes.
Topics: Aspirin; Bucladesine; Humans; Indomethacin; Inflammation; Neutrophils; Phagocytosis; Prostaglandins; | 1976 |
Possible relation of prostaglandins to PMN-derived mediators of host metabolic responses to inflammation.
Topics: Amino Acids; Animals; Aspirin; Biological Assay; Bucladesine; Cells, Cultured; Cyclic GMP; Cyclooxyg | 1977 |
Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Carrageenan; Cell Migration Inhibitio | 1975 |
Effects of anti-inflammatory drugs on the carrageenin-induced hind paw inflammation of rats deprived of endogenous precursors of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Dexamethasone; Fatty Acids, Essential; Indo | 1977 |
Peroxidase reactions during prostaglandin biosynthesis and their relationship to inflammation.
Topics: Animals; Arachidonic Acids; Aspirin; Indomethacin; Inflammation; Male; Mass Spectrometry; Peroxidase | 1979 |
Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Biphenyl Compoun | 1977 |
Alternatives to aspirin, derived from biological sources.
Topics: Animals; Aspirin; Enterobacter; Escherichia coli; Female; Inflammation; Male; Mice; Platelet Aggrega | 1977 |
Prostaglandins: in pain and inflammations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capillary Permeability; Cyclooxygenase In | 1977 |
Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Carrageenan; Cyclooxygen | 1977 |
Mechanism of action of aspirin in inflammation.
Topics: Aspirin; Humans; Inflammation; Lymphocytes; Prostaglandin Antagonists; Prostaglandins | 1977 |
The role of aspirin in gastric ulceration . Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.
Topics: Animals; Arthritis, Experimental; Aspirin; Atropine Derivatives; Bethanechol Compounds; Cold Tempera | 1978 |
Antiinflammatory activities of polymers of o-metacryloyloxybenzoic acid.
Topics: Acrylic Resins; Animals; Aspirin; Inflammation; Polymethacrylic Acids; Rats | 1978 |
[The therapeutic year].
Topics: Albuterol; Anti-Inflammatory Agents; Aspirin; Calcitonin; Colchicine; Drug Therapy; Endocrine System | 1976 |
Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Azathioprine; Biological Assay; Cyclophosphamide; Female | 1975 |
Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat.
Topics: Animals; Arthritis, Rheumatoid; Aspirin; Caffeine; Cyclooxygenase Inhibitors; Drug Therapy, Combinat | 1976 |
Antiinflammatory agents and inhibition of ocular prostaglandin synthetase.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Conjunctiva; Cyclooxygenase Inhibitors; Epinephrine; Eye | 1976 |
[Further studies of the action of an anti-inflammatory agent recently used in therapy].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Indomethacin; Inflammation; Phenylbutazone; Rats; Thiazo | 1977 |
Changes in the concentration of leucocytes and platelets in the peripheral blood during sterile inflammation in rabbits.
Topics: Animals; Aspirin; Blood Cell Count; Blood Platelets; Glycogen; Inflammation; Leukocyte Count; Leukoc | 1977 |
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Carrageenan; Chr | 1977 |
[New findings on the efficacy and mode of action of the horse chestnut saponin escin].
Topics: Animals; Aspirin; Bradykinin; Dose-Response Relationship, Drug; Escin; Exudates and Transudates; Fem | 1976 |
The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Aspirin; Blood Proteins; Cell Adhesion; | 1976 |
Experimental inhibition of prostaglandin-like inflammatory response after cryotherapy.
Topics: Animals; Anterior Chamber; Aspirin; Cryosurgery; Eye Diseases; Inflammation; Prostaglandin Antagonis | 1976 |
The effect of anti-inflammatory agents and inflammation on granulocyte adherence. Evidence for regulation by plasma factors.
Topics: Adhesiveness; Adult; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Depression, | 1976 |
Some pharmacological and toxicological studies on ketoprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Fever; Guinea Pigs; Indometha | 1976 |
Inflammatory disease and its control in rheumatic disorders.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Female; Gout; Hum | 1975 |
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap | 1975 |
Mechanisms of concanavalin A-induced inflammation in the rat.
Topics: Animals; Aspirin; Concanavalin A; Indomethacin; Inflammation; Kinins; Male; Prostaglandins; Rats; Ra | 1975 |
Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint.
Topics: Analgesia; Animals; Aspirin; Blood Pressure; Bradykinin; Carrageenan; Depression, Chemical; Dogs; Fe | 1975 |
Aspirin-like drugs and prostaglandins.
Topics: Anti-Inflammatory Agents; Aspirin; Depression, Chemical; Humans; Inflammation; Prostaglandins | 1975 |
Characteristic features of actinomycin D-induced paw inflammation of the rat.
Topics: Acid Phosphatase; Animals; Aspirin; Capillary Permeability; Dactinomycin; Dose-Response Relationship | 1975 |
Treatment of Kawasaki disease using the intravenous aspirin anti-inflammatory effect of salicylate.
Topics: Acute Disease; Aspirin; Child; Child, Preschool; Coronary Disease; Female; Humans; Infant; Inflammat | 1992 |
Effects of intravenous infusions of diaspirin cross-linked hemoglobin (DCLHb) on sheep.
Topics: Animals; Aspirin; Blood Substitutes; Complement C3a; Cross-Linking Reagents; Drug Tolerance; Female; | 1992 |
Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Benzimidazoles; | 1992 |
The role of the endothelial cell in leukotriene biosynthesis.
Topics: Animals; Aspirin; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Epop | 1992 |
[Use of acelysin solution in the treatment of acute purulent inflammatory diseases of soft tissues].
Topics: Adolescent; Adult; Aged; Animals; Anti-Infective Agents; Aspirin; Child; Drug Combinations; Female; | 1992 |
Aspirin.
Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation Disorders; Cell Membr | 1991 |
Inhibition of acute inflammation in the periphery by central action of salicylates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dexamethasone; Female; Indomethacin; Infl | 1991 |
Copper and aspirin treatment increase the antioxidant activity of plasma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Aspirin; Ceruloplasmin; Copper; End | 1990 |
The management of reaction in leprosy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Aspirin; Benzenesulfonates; Chloroquine | 1989 |
[The effect of acetylsalicylic acid on gastric transmural potential difference in healthy children and in children with inflammatory diseases].
Topics: Acute Disease; Aspirin; Blood Sedimentation; Child; Child, Preschool; Female; Gastric Juice; Gastric | 1989 |
New therapeutic approaches in asthma.
Topics: Adrenergic beta-Agonists; Aerosols; Airway Obstruction; Aspirin; Asthma; Bronchi; Bronchodilator Age | 1986 |
Background and discovery of lipocortins.
Topics: Animals; Annexins; Anti-Inflammatory Agents; Aspirin; Glucocorticoids; Glycoproteins; Humans; Inflam | 1986 |
Pharmacological modulation of localized inflammatory reactions: the nonsteroidal anti-inflammatory drug as an adjunct to therapy.
Topics: Animals; Arthus Reaction; Aspirin; Capillary Permeability; Female; Hemorrhage; Indomethacin; Inflamm | 1988 |
Two modes of analgesic action of aspirin, and the site of analgesic action of salicylic acid.
Topics: Analgesia; Animals; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Inflammati | 1986 |
Modifications in the responsiveness of rat ventrobasal thalamic neurons at different stages of carrageenin-produced inflammation.
Topics: Action Potentials; Acute-Phase Reaction; Animals; Aspirin; Carrageenan; Inflammation; Lidocaine; Mal | 1986 |
On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Dexame | 1986 |
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Inflammation; Kinetics; Male; Prostaglandins E; Rats; R | 1987 |
Prostaglandin synthesis and early biochemical events in the liver cells during the acute-phase response.
Topics: Acute-Phase Reaction; Animals; Aspirin; Dinoprost; Dinoprostone; Indomethacin; Inflammation; Liver; | 1987 |
Current modalities in arthritic diseases.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthrit | 1987 |
The effect of fosfosal and acetylsalicylic acid on leukocyte migration and PGE2 concentration in experimentally induced acute inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Migration Inhibition; Dinoprostone; | 1988 |
A possible drug interaction between aspirin and L-glutamine on some experimental inflammatory and analgesic models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Drug Interactions | 1988 |
Effects of paracetamol and acetylsalicylic acid on the post-operative course after experimental orthopaedic surgery in dogs.
Topics: Acetaminophen; Animals; Aspirin; Dogs; Edema; Female; Forelimb; Inflammation; Male; Pain, Postoperat | 1988 |
Discharge characteristics of receptors with fine afferents from normal and inflamed joints: influence of analgesics and prostaglandins.
Topics: Action Potentials; Afferent Pathways; Alprostadil; Animals; Arthritis; Aspirin; Cats; Dinoprostone; | 1986 |
Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints.
Topics: Afferent Pathways; Animals; Aspirin; Cats; Dinoprostone; Electrophysiology; Female; Indomethacin; In | 1986 |
[Aspirin in the treatment of inflammatory rheumatism in 1987].
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Child; Humans; Inflammation; Lupus Erythematosus, Systemic; R | 1987 |
[Influence of antibiotics on anti-inflammatory activity of anti-inflammatory drugs in simultaneous administration].
Topics: Ampicillin; Animals; Aspirin; Cephalexin; Drug Interactions; Fenoprofen; Guinea Pigs; Histamine; Inf | 1987 |
The cellular inflammatory response in nicotinate skin reactions.
Topics: Adult; Aspirin; Dermatitis, Atopic; Erythema; Female; Furans; Humans; Inflammation; Leukocyte Count; | 1987 |
Pharmacology of upper airways challenge.
Topics: Aspirin; Cyproheptadine; Exocytosis; Humans; Hypersensitivity; Inflammation; Mast Cells; Nasal Mucos | 1987 |
The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspiri | 1987 |
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Edema; Indomethacin; Inflammation; Male; | 1987 |
Benzydamine, an unique model of anti-inflammatory activity.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzydamine; Inflamma | 1987 |
Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Formaldehyde; Hindlimb; Indomethacin; Inflammati | 1986 |
Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation.
Topics: Animals; Aspirin; Blood Pressure; Bradykinin; Bromelains; Dogs; Hypertension; Inflammation; Pain; Pr | 1986 |
Analgesic, anti-inflammatory and oxy-radical scavenger activity of imidazole and imidazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Gastritis | 1985 |
[The modes of anti-inflammatory and analgesic actions of aspirin and salicylic acid].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Disease Models | 1985 |
The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic | 1985 |
Animal models for the study of atypical anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzydamine; Cortisone; Disease M | 1986 |
A classification of headache.
Topics: Antidepressive Agents; Anxiety; Arteritis; Aspirin; Depression; Ergot Alkaloids; Facial Neuralgia; H | 1970 |
Prostaglandins, aspirin, and analgesia.
Topics: Analgesia; Aspirin; Depression, Chemical; Humans; Inflammation; Prostaglandins | 1973 |
Effects of nonsteroid anti-inflammatory agents and some dicoumarol derivatives on platelet aggregation, fibrinolysis and stabilization of cell membrane in vitro.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cell Membrane; Chloroquine; Coumarins; Depressio | 1972 |
Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Carrageenan; Edema; Histamine H1 Antagonists; Ind | 1973 |
Letter: The action of anti-inflammatory drugs in two models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Dextrans; Female; Hindlimb; Inflammation; I | 1973 |
[Influence of various drugs on the tissue permeability. 6. Effect of anti-inflammatory drugs on quantitative changes in connective tissue components in inflamed tissues of filter paper-implanted rats].
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Barbiturates; Benzyl Compounds; Connective | 1973 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
Prostaglandins and anti-inflammatory drugs in the dog knee joint.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dogs; Indomethacin; Inflammation; Knee Joint; Phenylbuta | 1972 |
A modification of rat adjuvant arthritis for testing antirheumatic drugs.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthr | 1972 |
Pain in osteoarthrosis.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Cartilage Diseases; Exercise Therapy; Hip; Humans; Im | 1974 |
Prostaglandins in synovial inflammatory disease.
Topics: Arthritis; Aspirin; Hemophilia A; Humans; Indomethacin; Inflammation; Prostaglandins; Synovial Fluid | 1974 |
Blood platelets and the inflammatory process.
Topics: Aspirin; Blood Platelets; Blood Proteins; Capillary Permeability; Hemostasis; Histamine; Humans; Ind | 1974 |
][A new method for screening of analgesics applied to heat induced inflammatory pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Hab | 1974 |
Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Biological Assay; Blood | 1973 |
[A new anti-inflammatory agent: calcium bucloxate in pediatrics].
Topics: Adolescent; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Bronchopneumonia; | 1974 |
Studies on phagocytosis. II. The effect of nonsteroidal anti-inflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Carbon Isotopes; Dogs; Dose-Respon | 1972 |
Interaction between 'sensitized lymphocytes' and antigen in vitro. V. Vascular permeability induced by skin-reactive factor.
Topics: Aminocaproates; Animals; Antigens; Aprotinin; Aspirin; Blood Coagulation Tests; Capillary Permeabili | 1972 |
Studies on the mode of action of non-steroid anti-inflammatory drugs.
Topics: Animals; Aspirin; Cell Movement; Disease Models, Animal; Indomethacin; Inflammation; Leukocytes; Mef | 1972 |
Effect of non-steroid anti-inflammatory drugs on prostaglandin biosynthesis by skin.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Female; In Vitro Techniques; Indomethacin; Inflammation; | 1973 |
Numerical scale for evaluation of the patient with inflammatory joint disease.
Topics: Activities of Daily Living; Adolescent; Arthritis, Juvenile; Aspirin; Disability Evaluation; Female; | 1973 |
Anti-inflammatory activity of an indigenous plant--Paederia foetida (Gandhali).
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Croton Oil; Ethanol; Female; Formaldehyde; Hydrocortison | 1973 |
Correlation of mucosal histology and aspirin intake in chronic gastric ulcer.
Topics: Adult; Aged; Aspirin; Caffeine; Chronic Disease; Epithelium; Female; Gastric Mucosa; Gastritis; Huma | 1973 |
Influence of prostaglandins (Pg) E2 and F2 on the inflammatory process.
Topics: Animals; Arthritis; Aspirin; Carrageenan; Croton Oil; Edema; Foot; Granuloma; Hindlimb; Hydrocortiso | 1973 |
[Influence of various drugs on the tissue permeability. 7. Effect of anti-inflammatory drugs on the changes in mucopolysaccharase activity in inflamed tissues of filter paper-implanted rats].
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Enzyme Activation; Female; F | 1973 |
Aspirin-like drugs and prostaglandins.
Topics: Aspirin; Drug Interactions; Fever; Heart; Humans; Inflammation; Prostaglandins; Stimulation, Chemica | 1973 |
Pharmacological properties of imidazole. I. Analgesic and anti-inflammatory actions.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Arthritis; Aspirin; Brad | 1973 |
[Anti-complement activity in vitro and in vivo of some non-steroid anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Complement Inactivator Proteins; Flufenamic Acid; Hemoly | 1973 |
Biochemical investigations of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370). 2. Action on local and systemic chemical responses in the rat with an experimental inflammatory process.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Blood Proteins; Carrageenan; Collagen; Female; Fibrinoge | 1972 |
Release of lysosomal enzymes in experimental inflammations: effects of anti-inflammatory drugs.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Betamethasone; C | 1972 |
The experimental modification of lysosomal dysfunction by anti-inflammatory drugs acting in vitro.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Cells, Cultured; Histamine; | 1972 |
Response of "acute phase" globulins in different models of inflammation in rats.
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Arthritis; Aspirin; Disease Models, Animal; Granulom | 1971 |
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch | 1971 |
New light on inflammation.
Topics: Animals; Aspirin; Blood Vessels; Dogs; Humans; Indomethacin; Inflammation; Prostaglandins; Rats; Ski | 1971 |
Wy 23205, a new non-steroidal anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Bradykinin; Gastrointestinal Diseases; Guinea | 1971 |
[On the use of a creosotamide-acetylsalicylic acid and proteolytic enzyme combination in genital inflammatory processes].
Topics: Aspirin; Chymotrypsin; Cresols; Evaluation Studies as Topic; Female; Genital Diseases, Female; Human | 1971 |
The effect of oxyphenbutazone on partial thromboplastin time and lack of effect on Hageman factor in guinea pigs.
Topics: Animals; Aspirin; Blood Coagulation Tests; Capillary Permeability; Factor XII; Guinea Pigs; Inflamma | 1971 |
Heterocyclic systems with a bridgehead nitrogen. II. 6-Chloroimidazo[2,1-b]thiazole and some of its 5-substituted derivatives.
Topics: Animals; Aspirin; Blood Pressure; Chemical Phenomena; Chemistry; Enterobacteriaceae; Female; Fungi; | 1969 |
The pharmacological properties of ibuprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Codeine; Dextropropoxyphene; Eryt | 1969 |
A new anti-inflammatory agent 1-(4-chlorobenzoyl)-3-(5-tetrazolylmethyl) indole (BL-R743).
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Carrageenan; Dextrans; Drug Syner | 1969 |
Analgetic activity of alpha-1-(1-methyl-3-pyrrolidinyl)-1-phenylpropyl propionate fumarate (AHR-1767).
Topics: Analgesics; Animals; Aspirin; Codeine; Dextropropoxyphene; Dogs; Female; Fumarates; Inflammation; Ma | 1969 |
Observations on the pharmacological properties of inflammatory exudate.
Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Aspirin; Calcium; Carrageenan; Ede | 1969 |
[Current analgesic anti-inflammatory drugs].
Topics: Analgesics; Aniline Compounds; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver In | 1970 |
Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzopyrans; Carrageenan; Cellulose; Dogs; Indomethacin; | 1970 |
[Experimental ophthalmic anti-inflammatory activity of some steroid and non-steroid drugs topically applied].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aspirin; Eye; Eye Diseases; Glucocortico | 1970 |
Some aspects in the quantitation of inflammation in joints of patients suffering from rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Reactive; Arthritis, Rheumatoid; Aspir | 1970 |
Pharmacological investigations of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
Topics: Acid Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Antibody Formation; Aspirin; Blood | 1970 |
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity.
Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capill | 1970 |
Effect of acetylsalicylic acid and hydrocortisone on the pleural response to Evans blue-carrageenin.
Topics: Animals; Aspirin; Carrageenan; Coloring Agents; Hydrocortisone; Inflammation; Male; Pleura; Pleural | 1968 |
[Aspirin to non-steroid anti-inflammatory drugs--for an understanding of inflammation and anti-inflammatory mechanisms].
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Histamine; Humans; Inflammati | 1968 |
[Clinical evaluation of non-steroid anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Flufenamic Acid; Humans; Indomethacin; Inf | 1968 |
Radiometric measurement of paw temperature changes associated with local inflammation.
Topics: Animals; Aspirin; Body Temperature; Chlorpheniramine; Edema; Inflammation; Radiometry; Rats; Yeasts | 1966 |