aspirin has been researched along with Infarct, Lacunar in 30 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with lacunar stroke, DAPT using cilostazol had significant benefits in reducing recurrent ischemic stroke incidence compared with SAPT without increasing the risk of severe or life-threatening bleeding." | 9.69 | Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial. ( Hoshino, H; Houkin, K; Kimura, K; Matsumoto, M; Minematsu, K; Naritomi, H; Nishiyama, Y; Okada, Y; Origasa, H; Otsuka, T; Sakai, N; Terayama, Y; Tomimoto, H; Tominaga, T; Toyoda, K; Uchiyama, S; Yamaguchi, K; Yamaguchi, T; Yasuda, S, 2023) |
| "This study evaluated the efficacy of combined therapy with probucol and cilostazol on endothelial function in silent lacunar cerebral infarcts (SLCI) and mild hypercholesterolemia." | 9.19 | Combined therapeutic effect of probucol and cilostazol on endothelial function in patients with silent cerebral lacunar infarcts and hypercholesterolemia: a preliminary study. ( Hattori, H; Ishihara, M; Nagata, M; Takase, B; Tanaka, Y, 2014) |
| "Among patients with recent lacunar strokes, the addition of clopidogrel to aspirin did not significantly reduce the risk of recurrent stroke and did significantly increase the risk of bleeding and death." | 9.16 | Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. ( Benavente, OR; Coffey, CS; Hart, RG; McClure, LA; Pearce, LA; Szychowski, JM, 2012) |
| "In patients with lacunar stroke, DAPT using cilostazol had significant benefits in reducing recurrent ischemic stroke incidence compared with SAPT without increasing the risk of severe or life-threatening bleeding." | 5.69 | Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial. ( Hoshino, H; Houkin, K; Kimura, K; Matsumoto, M; Minematsu, K; Naritomi, H; Nishiyama, Y; Okada, Y; Origasa, H; Otsuka, T; Sakai, N; Terayama, Y; Tomimoto, H; Tominaga, T; Toyoda, K; Uchiyama, S; Yamaguchi, K; Yamaguchi, T; Yasuda, S, 2023) |
| "This study evaluated the efficacy of combined therapy with probucol and cilostazol on endothelial function in silent lacunar cerebral infarcts (SLCI) and mild hypercholesterolemia." | 5.19 | Combined therapeutic effect of probucol and cilostazol on endothelial function in patients with silent cerebral lacunar infarcts and hypercholesterolemia: a preliminary study. ( Hattori, H; Ishihara, M; Nagata, M; Takase, B; Tanaka, Y, 2014) |
| "Among patients with recent lacunar strokes, the addition of clopidogrel to aspirin did not significantly reduce the risk of recurrent stroke and did significantly increase the risk of bleeding and death." | 5.16 | Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. ( Benavente, OR; Coffey, CS; Hart, RG; McClure, LA; Pearce, LA; Szychowski, JM, 2012) |
| "Clopidogrel combined with aspirin is routinely prescribed after coronary artery stenting, in patients with acute coronary syndromes, and recently to prevent stroke in patients with acute minor ischemic stroke and TIA." | 4.91 | Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials. ( Bakheet, MF; Hart, RG; Pearce, LA, 2015) |
| "Patients with lacunar stroke and CMBs likely harbor a more advanced form of cerebral small vessel disease in need of efficacious therapeutic strategies." | 2.84 | Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions. ( Anderson, DC; Bazan, C; Benavente, OR; Catanese, L; Hart, RG; Kase, CS; Marti-Fabregas, J; McClure, LA; Pearce, LA; Sharma, M; Shoamanesh, A, 2017) |
| "In patients with a recent lacunar stroke while taking ASA, the addition of clopidogrel did not result in reduction of vascular events vs continuing ASA only." | 2.79 | ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection? ( Anderson, DC; Benavente, OR; Côté, R; Hart, RG; McClure, LA; Talbert, RL; Zhang, Y, 2014) |
| "Among 1244 patients with lacunar stroke (mean age, 63." | 2.79 | C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study. ( Benavente, OR; Coffey, CS; Del Brutto, OH; Elkind, MS; Luna, JM; McClure, LA; Meyer, BC; Pettigrew, LC; Pretell, EJ; Roldan, A; Tapia, J; White, C; Zhang, Y, 2014) |
| "Heat stroke is a life-threatening disease characterized by hyperthermia and neurological dysfunction." | 1.56 | Unusual manifestation of heat stroke: Isolated trochlear nerve palsy. ( Han, S; Kim, BK; Yum, KS, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 26 (86.67) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, X | 1 |
| Cen, K | 1 |
| Cui, Y | 1 |
| Zhang, Y | 3 |
| Feng, X | 1 |
| Nishiyama, Y | 1 |
| Kimura, K | 1 |
| Otsuka, T | 1 |
| Toyoda, K | 1 |
| Uchiyama, S | 1 |
| Hoshino, H | 1 |
| Sakai, N | 1 |
| Okada, Y | 1 |
| Origasa, H | 1 |
| Naritomi, H | 1 |
| Houkin, K | 1 |
| Yamaguchi, K | 1 |
| Minematsu, K | 1 |
| Matsumoto, M | 1 |
| Tominaga, T | 1 |
| Tomimoto, H | 1 |
| Terayama, Y | 1 |
| Yasuda, S | 1 |
| Yamaguchi, T | 1 |
| Berberich, A | 2 |
| Schneider, C | 1 |
| Herweh, C | 1 |
| Hielscher, T | 1 |
| Reiff, T | 1 |
| Bendszus, M | 1 |
| Gumbinger, C | 2 |
| Ringleb, P | 1 |
| Han, S | 1 |
| Kim, BK | 1 |
| Yum, KS | 1 |
| Shoamanesh, A | 2 |
| Pearce, LA | 7 |
| Bazan, C | 2 |
| Catanese, L | 1 |
| McClure, LA | 6 |
| Sharma, M | 3 |
| Marti-Fabregas, J | 1 |
| Anderson, DC | 5 |
| Kase, CS | 1 |
| Hart, RG | 8 |
| Benavente, OR | 10 |
| Hawkes, MA | 1 |
| Braksick, SA | 1 |
| Zhang, W | 2 |
| Wijdicks, EFM | 1 |
| Rabinstein, AA | 1 |
| Kong, T | 1 |
| Chen, J | 1 |
| Sun, K | 1 |
| Wang, J | 1 |
| Song, L | 1 |
| Wang, D | 1 |
| Hui, R | 1 |
| Ringleb, PA | 1 |
| Gutierrez, J | 1 |
| Wadiwala, MF | 1 |
| Kamal, AK | 1 |
| Opherk, C | 1 |
| Takase, B | 1 |
| Nagata, M | 1 |
| Hattori, H | 1 |
| Tanaka, Y | 1 |
| Ishihara, M | 1 |
| Côté, R | 1 |
| Talbert, RL | 1 |
| Castilla-Guerra, L | 1 |
| Sacco, RL | 1 |
| Elkind, MS | 1 |
| Luna, JM | 1 |
| Coffey, CS | 3 |
| Roldan, A | 1 |
| Del Brutto, OH | 1 |
| Pretell, EJ | 1 |
| Pettigrew, LC | 1 |
| Meyer, BC | 1 |
| Tapia, J | 2 |
| White, C | 1 |
| Markun, S | 1 |
| Connolly, SJ | 1 |
| Palacio, S | 1 |
| Hillis, AE | 1 |
| Jacova, C | 1 |
| Bakheet, MF | 1 |
| Kwok, CS | 1 |
| Copley, HC | 1 |
| Myint, PK | 1 |
| Loke, YK | 1 |
| Field, TS | 3 |
| Asinger, RW | 1 |
| Smyth, NG | 1 |
| De, SK | 1 |
| Spence, JD | 1 |
| Rayner, BL | 1 |
| Odden, MC | 1 |
| Sawaya, BP | 1 |
| White, CL | 1 |
| Peralta, CA | 1 |
| Pergola, PE | 1 |
| Wilson, LK | 1 |
| Arauz, A | 1 |
| Benavente, O | 1 |
| Szychowski, JM | 1 |
| Giger, JN | 1 |
| Brannon, CB | 1 |
| Han, SW | 1 |
| Lee, SS | 1 |
| Kim, SH | 1 |
| Lee, JH | 1 |
| Kim, GS | 1 |
| Kim, OJ | 1 |
| Koh, IS | 1 |
| Lee, JY | 1 |
| Suk, SH | 1 |
| Lee, SI | 1 |
| Nam, HS | 1 |
| Kim, WJ | 1 |
| Yong, SW | 1 |
| Lee, KY | 1 |
| Park, JH | 1 |
| Diener, HC | 1 |
| Weber, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Low-dose Aspirin Therapy in Patients With Non-Cardioembolic Ischemic Stroke and Microbleeds[NCT04504864] | Phase 4 | 400 participants (Anticipated) | Interventional | 2020-10-01 | Recruiting | ||
| Secondary Prevention of Small Subcortical Strokes (SPS3) Trial[NCT00059306] | Phase 3 | 3,020 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Study for the Multi-Center Placebo-Controlled Double-Blind Clinical Trial for the Evaluation of the Effect of Cilostazol on Pulsatility Index of Transcranial Doppler in the Acute Lacunar Infarction Patients[NCT00741286] | Phase 4 | 203 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00741286)
Timeframe: 90 days
| Intervention | participants (Number) |
|---|---|
| Asprin Plus Placebo | 1 |
| Asprin Plus Cilostazol | 1 |
The PI is designed to measure vascular resistance and characterizes the shape of the spectral waveform. For the study, the mean, systolic, and diastolic flow velocities were measured using TCD. Gosling's PI was determined as the difference between the peak systolic and end-diastolic velocities divided by the mean flow velocity in each artery.The changes of MCA and BA PIs at 14 and 90 days from the baseline TCD study was calculated for the study. (NCT00741286)
Timeframe: 14 days and 90 days from the baseline TCD study
| Intervention | ratio (Mean) | |||||
|---|---|---|---|---|---|---|
| Changes of PI in Right MCA (14 days) | Changes of PI in Right MCA (90 days) | Changes of PI in Left MCA (14 days) | Changes of PI in Left MCA (90 days) | Changes of PI in BA (14 days) | Changes of PI in BA (90 days) | |
| Asprin Plus Cilostazol | 0.08 | 0.14 | 0.1 | 0.13 | 0.09 | 0.18 |
| Asprin Plus Placebo | 0.07 | 0.09 | 0.08 | 0.07 | 0.09 | 0.1 |
3 reviews available for aspirin and Infarct, Lacunar
| Article | Year |
|---|---|
Antiplatelet therapy for secondary prevention of lacunar stroke: a systematic review and network meta-analysis.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Network Meta-Analysis; Platelet | 2023 |
Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; | 2015 |
Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke: pooled analysis of randomized trials.
Topics: Aged; Aspirin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Placebos; Platelet Aggr | 2015 |
14 trials available for aspirin and Infarct, Lacunar
| Article | Year |
|---|---|
Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; | 2023 |
Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions.
Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Double-Blind Method; Female; Humans; Magnetic Resonance I | 2017 |
Combined therapeutic effect of probucol and cilostazol on endothelial function in patients with silent cerebral lacunar infarcts and hypercholesterolemia: a preliminary study.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Agents; Cholinergic Antagonists; Cilostazol; Drug T | 2014 |
ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?
Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; | 2014 |
C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study.
Topics: Aged; Antihypertensive Agents; Aspirin; Biomarkers; Blood Pressure; C-Reactive Protein; Clopidogrel; | 2014 |
Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged | 2014 |
Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.
Topics: Aged; Aspirin; Blood Pressure; Clopidogrel; Cognition; Double-Blind Method; Drug Therapy, Combinatio | 2014 |
Left Ventricular Geometry on Transthoracic Echocardiogram and Prognosis after Lacunar Stroke: The SPS3 Trial.
Topics: Aged; Aspirin; Clopidogrel; Echocardiography; Female; Heart Ventricles; Humans; Magnetic Resonance I | 2015 |
Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial.
Topics: Aspirin; Blood Pressure; Blood Pressure Determination; Clopidogrel; Drug Therapy, Combination; Femal | 2016 |
Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.
Topics: Antihypertensive Agents; Aspirin; Cerebral Infarction; Clopidogrel; Constriction, Pathologic; Double | 2016 |
[Branch atheromatous disease: prognosis and management. The SPS3 experience].
Topics: Aspirin; Basilar Artery; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Stroke, Lacun | 2011 |
Effects of clopidogrel added to aspirin in patients with recent lacunar stroke.
Topics: Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hem | 2012 |
Effect of cilostazol in acute lacunar infarction based on pulsatility index of transcranial Doppler (ECLIPse): a multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Aged; Aspirin; Cilostazol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Mid | 2013 |
Clopidogrel added to aspirin adds no benefit but bleeding risk in patients with recent lacunar stroke.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combinati | 2013 |
13 other studies available for aspirin and Infarct, Lacunar
| Article | Year |
|---|---|
Risk factors associated with progressive lacunar strokes and benefit from dual antiplatelet therapy.
Topics: Aged; Aspirin; Female; Humans; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Pr | 2020 |
Unusual manifestation of heat stroke: Isolated trochlear nerve palsy.
Topics: Aged; Aspirin; Cerebral Infarction; Fibrinolytic Agents; Heat Stroke; Humans; Male; Mesencephalon; R | 2020 |
Can we stop the stuttering in stroke? Interventions in 40 patients with acute lacunes.
Topics: Aspirin; Blood Pressure; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Humans; Mal | 2019 |
Aspirin reduced recurrent stroke risk in patients with lacunar stroke.
Topics: Adult; Aged; Aspirin; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Plat | 2019 |
Response by Berberich et al to Letters Regarding Article, "Dual Antiplatelet Therapy Improves Functional Outcome in Patients With Progressive Lacunar Strokes".
Topics: Aspirin; Dual Anti-Platelet Therapy; Humans; Platelet Aggregation Inhibitors; Stroke; Stroke, Lacuna | 2019 |
Letter by Gutierrez Regarding Article, "Dual Antiplatelet Therapy Improves Functional Outcome in Patients With Progressive Lacunar Strokes".
Topics: Aspirin; Dual Anti-Platelet Therapy; Humans; Platelet Aggregation Inhibitors; Stroke; Stroke, Lacuna | 2019 |
My patient had a small vessel stroke, are two antiplatelet agents better than one?
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggrega | 2013 |
[Not Available].
Topics: Aspirin; Female; Humans; Male; Platelet Aggregation Inhibitors; Stroke, Lacunar; Ticlopidine | 2013 |
Treating lacunar strokes occurring on aspirin: adding clopidogrel is not the simple solution.
Topics: Aspirin; Clopidogrel; Female; Humans; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; | 2014 |
[Adding clopidogrel after stroke while on aspirin-does not help, only hurts].
Topics: Aspirin; Female; Humans; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Stroke, Lacu | 2014 |
Blood pressure control after stroke: too little, too late, or too soon to tell?
Topics: Aspirin; Blood Pressure; Clopidogrel; Cognition; Female; Humans; Male; Platelet Aggregation Inhibito | 2014 |
J Curve and Cuff Artefact, and Diagnostic Inertia in Resistant Hypertension.
Topics: Aspirin; Blood Pressure; Female; Humans; Hypertension; Male; Secondary Prevention; Stroke, Lacunar; | 2016 |
African-Americans and strokes: minutes and hours make the difference.
Topics: Aspirin; Black or African American; Female; Fibrinolytic Agents; Foramen Ovale, Patent; Health Statu | 2011 |