aspirin and Infant, Newborn, Diseases studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.

Research Excerpts

Excerpt	Relevance	Reference
"This study aimed to evaluate the maternal and fetal results in women undergoing antihypertensive therapy (low aspirin or labetalol) with mild to severe chronic hypertension relative to women without medicines."	9.34	Treatment of pregnancy-induced hypertension compared with labetalol, low dose aspirin and placebo. ( Wang, F; Xiang, X; Zhao, N; Zhou, Z, 2020)
"To perform a meta-analysis determining the association of low-dose aspirin treatment with subsequent abruptio placentae or perinatal mortality."	8.79	Low-dose aspirin: lack of association with an increase in abruptio placentae or perinatal mortality. ( Cliver, SP; Cutter, GR; Goldenberg, RL; Hauth, JC; Parker, CR, 1995)
"To estimate whether low-dose aspirin use is associated with an altered risk of delivering a small-for-gestational age (SGA) neonate among women with a history of having an SGA neonate in a prior pregnancy."	8.12	Low-Dose Aspirin for Preventing Birth of a Small-For-Gestational Age Neonate in a Subsequent Pregnancy. ( Bergman, L; Cluver, CA; Hastie, R; Hesselman, S; Kupka, E; Lindquist, A; Tong, S; Walker, SP; Wikström, AK, 2022)
" The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects."	7.66	Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981)
" there was no evidence that aspirin taken in pregnancy is a cause of stillbirth, neonatal death, or reduced birth-weight."	7.65	Perinatal mortality and birth-weight in relation to aspirin taken during pregnancy. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1976)
"This study aimed to evaluate the maternal and fetal results in women undergoing antihypertensive therapy (low aspirin or labetalol) with mild to severe chronic hypertension relative to women without medicines."	5.34	Treatment of pregnancy-induced hypertension compared with labetalol, low dose aspirin and placebo. ( Wang, F; Xiang, X; Zhao, N; Zhou, Z, 2020)
"To compare the effect of aspirin and enoxaparin on live births in women with unexplained recurrent miscarriages, as well as secondary outcomes including birth weight, uterine and umbilical blood flows, and congenital malformations."	5.12	A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages. ( Brenner, B; Carp, H; Dolitzky, M; Inbal, A; Segal, Y; Weiss, A, 2006)
"To perform a meta-analysis and meta-regression of randomized controlled trials (RCTs) to evaluate the impact of low-dose aspirin (LDA) on perinatal outcome, independent of its effect on pre-eclampsia (PE), preterm birth and low birth weight."	5.05	Impact of low-dose aspirin on adverse perinatal outcome: meta-analysis and meta-regression. ( Hartel, G; Kumar, S; Robertson, NT; Turner, JM, 2020)
"To perform a meta-analysis determining the association of low-dose aspirin treatment with subsequent abruptio placentae or perinatal mortality."	4.79	Low-dose aspirin: lack of association with an increase in abruptio placentae or perinatal mortality. ( Cliver, SP; Cutter, GR; Goldenberg, RL; Hauth, JC; Parker, CR, 1995)
"To estimate whether low-dose aspirin use is associated with an altered risk of delivering a small-for-gestational age (SGA) neonate among women with a history of having an SGA neonate in a prior pregnancy."	4.12	Low-Dose Aspirin for Preventing Birth of a Small-For-Gestational Age Neonate in a Subsequent Pregnancy. ( Bergman, L; Cluver, CA; Hastie, R; Hesselman, S; Kupka, E; Lindquist, A; Tong, S; Walker, SP; Wikström, AK, 2022)
" On day 2 post partum, mothers were questioned regarding maternal risk factors, including the use of either aspirin or acetaminophen during the last week of pregnancy."	3.66	Neonatal intracranial hemorrhage and maternal use of aspirin. ( Braithwaite, WR; Guggenheim, MA; Johnson, ML; Peterson, RG; Rumack, BH; Rumack, CM, 1981)
" The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects."	3.66	Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981)
", malformation rates were similar in the children of 35 418 women not exposed to aspirin, 9736 with intermediate exposure, and 5128 women heavily exposed during the first four lunar months of pregnancy."	3.65	Aspirin and congenital malformations. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1976)
" there was no evidence that aspirin taken in pregnancy is a cause of stillbirth, neonatal death, or reduced birth-weight."	3.65	Perinatal mortality and birth-weight in relation to aspirin taken during pregnancy. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1976)
"Over-the-counter antipyretics (acetaminophen, aspirin, ibuprofen) and/or analgesics (acetaminophen, aspirin, diclofenac, ibuprofen, naproxen) are relatively safe for adults."	2.48	[Developmental toxicity of the over-the-counter analgetics and antypiretics]. ( Burdan, F; Cendrowska-Pinkosz, M; Dworzańska, A; Dworzański, W; Kubiatowski, T; Starosławska, E; Szumiło, J; Urbańczyk-Zawadzka, M, 2012)
"Maternal bleeding was confined to excessive intrapartum or post-partum blood loss."	1.26	Effects of acetylsalicylic-acid ingestion on maternal and neonatal hemostasis. ( Elrad, H; Graeber, JE; Gross, SJ; Stuart, MJ, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (77.42)	18.7374
1990's	1 (3.23)	18.2507
2000's	1 (3.23)	29.6817
2010's	2 (6.45)	24.3611
2020's	3 (9.68)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728]	Phase 3	19 participants (Actual)	Interventional	2013-01-01	Completed
Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension: A Pilot Study[NCT04908982]	Phase 4	60 participants (Anticipated)	Interventional	2021-05-28	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Impact of low-dose aspirin on adverse perinatal outcome: meta-analysis and meta-regression. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2020, Volume: 55, Issue:2 Topics: Abruptio Placentae; Apgar Score; Aspirin; Delivery, Obstetric; Female; Fetal Growth Retardation; Hum	2020
[Developmental toxicity of the over-the-counter analgetics and antypiretics]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2012, Volume: 32, Issue:192 Topics: Adult; Analgesics; Antipyretics; Aspirin; Female; Fetal Diseases; Humans; Infant, Newborn; Infant, N	2012
[Risks of simultaneous tocolytic treatment with beta adrenergic and PG inhibiting agents]. Zeitschrift fur Geburtshilfe und Perinatologie, 1981, Volume: 185, Issue:6 Topics: Adrenergic beta-Antagonists; Aspirin; Drug Interactions; Drug Therapy, Combination; Female; Humans;	1981
Preterm parturition. Prostaglandin synthetase inhibitors. Seminars in perinatology, 1981, Volume: 5, Issue:3 Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P	1981
Low-dose aspirin: lack of association with an increase in abruptio placentae or perinatal mortality. Obstetrics and gynecology, 1995, Volume: 85, Issue:6 Topics: Abruptio Placentae; Aspirin; Double-Blind Method; Female; Fetal Growth Retardation; Humans; Incidenc	1995
[Drug therapy of patent ductus arteriosus in premature and newborn infants]. Kinderarztliche Praxis, 1978, Volume: 46, Issue:12 Topics: Apnea; Aspirin; Chloroquine; Digitalis Glycosides; Ductus Arteriosus, Patent; Humans; Indomethacin;	1978
Adverse hematologic effects of drugs. Pediatric clinics of North America, 1972, Volume: 19, Issue:4 Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents	1972

Article	Year
Treatment of pregnancy-induced hypertension compared with labetalol, low dose aspirin and placebo. Cellular and molecular biology (Noisy-le-Grand, France), 2020, Dec-31, Volume: 66, Issue:8 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Blood Pressure; Do	2020
A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages. Fertility and sterility, 2006, Volume: 86, Issue:2 Topics: Abortion, Habitual; Abortion, Induced; Adult; Anticoagulants; Aspirin; Birth Rate; Birth Weight; Eno	2006

Article	Year
Low-Dose Aspirin for Preventing Birth of a Small-For-Gestational Age Neonate in a Subsequent Pregnancy. Obstetrics and gynecology, 2022, 04-01, Volume: 139, Issue:4 Topics: Aspirin; Birth Weight; Cohort Studies; Female; Fetal Growth Retardation; Gestational Age; Humans; In	2022
Myocardial infarction in a neonate. Lessons for neonatal and internal medicine. Hamostaseologie, 2017, Aug-08, Volume: 37, Issue:3 Topics: Aspirin; Cardiotonic Agents; Child, Preschool; Combined Modality Therapy; Coronary Thrombosis; Echoc	2017
A SIMPLIFIED VIEW OF FLUID THERAPY. Pediatric clinics of North America, 1964, Volume: 11 Topics: Acidosis; Adrenal Insufficiency; Aspirin; Calcium; Child; Cystic Fibrosis; Dehydration; Diabetes Mel	1964
Aspirin and maternal or neonatal hemostasis. The New England journal of medicine, 1983, Feb-03, Volume: 308, Issue:5 Topics: Aspirin; Female; Hemorrhage; Hemostasis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Materna	1983
Effects of acetylsalicylic-acid ingestion on maternal and neonatal hemostasis. The New England journal of medicine, 1982, Oct-07, Volume: 307, Issue:15 Topics: Adult; Aspirin; Blood Coagulation Tests; Female; Fetus; Gestational Age; Hemoglobinometry; Hemorrhag	1982
Neonatal intracranial hemorrhage and maternal use of aspirin. Obstetrics and gynecology, 1981, Volume: 58, Issue:5 Suppl Topics: Acetaminophen; Aspirin; Cerebral Hemorrhage; Female; Gestational Age; Humans; Infant, Low Birth Weig	1981
Maternal drug exposure and perinatal intracranial hemorrhage. Obstetrics and gynecology, 1981, Volume: 58, Issue:6 Topics: Aspirin; Cerebral Hemorrhage; Female; Fetal Diseases; Humans; Infant, Newborn; Infant, Newborn, Dise	1981
Effects of aspirin and acetaminophen in pregnancy and in the newborn. Archives of internal medicine, 1981, Feb-23, Volume: 141, Issue:3 Spec No Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Aspirin; Blood Platelets; Female; Fetus; Humans	1981
Aspirin and congenital malformations. Lancet (London, England), 1976, Jun-26, Volume: 1, Issue:7974 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aspirin; Birth Weight; Female; Humans; Infant,	1976
Perinatal mortality and birth-weight in relation to aspirin taken during pregnancy. Lancet (London, England), 1976, Jun-26, Volume: 1, Issue:7974 Topics: Aspirin; Birth Weight; Black People; Female; Fetal Death; Humans; Infant, Newborn; Infant, Newborn,	1976
[Neonatal hemorrhage due to maternal antiplatelet therapy]. Harefuah, 1979, Volume: 97, Issue:7-8 Topics: Acute Disease; Aspirin; Dipyridamole; Female; Gastrointestinal Hemorrhage; Humans; Infant, Newborn;	1979
Platelet function in the neonate. The American journal of pediatric hematology/oncology, 1979,Fall, Volume: 1, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelet Dis	1979
[Possibility of closure of the patent dutus arteriosus by drug therapy in the management of congenital defects in the newborn infant (preliminary report)]. Orvosi hetilap, 1978, Sep-17, Volume: 119, Issue:38 Topics: Aspirin; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male	1978
[Effect of drug therapy during pregnancy on the clotting potential of the newborn]. Zentralblatt fur Gynakologie, 1977, Volume: 99, Issue:8 Topics: Aspirin; Blood Coagulation Disorders; Drug-Related Side Effects and Adverse Reactions; Female; Hemos	1977
Intrauterine salicylate intoxication in a newborn. A case report. Clinical pediatrics, 1976, Volume: 15, Issue:10 Topics: Acetazolamide; Aspirin; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal	1976
Drugs affecting platelet function tests: their effects on haemostasis and surgical bleeding. Thrombosis et diathesis haemorrhagica, 1975, Sep-30, Volume: 34, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation Disorders; Blood Donors; Blood P	1975
A clinical look at the problem of drugs in pregnancy and their effect on the fetus. Canadian Medical Association journal, 1975, Mar-22, Volume: 112, Issue:6 Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse	1975
Simultaneous vasculitis in a mother and newborn infant. The Journal of pediatrics, 1975, Volume: 87, Issue:3 Topics: Adult; Arthritis; Aspirin; Female; Gangrene; Gentamicins; Heparin; Humans; Infant, Newborn; Infant,	1975
The platelet of the newborn infant. 5-Hydroxytryptamine uptake and release. Thrombosis et diathesis haemorrhagica, 1973, Volume: 30, Issue:2 Topics: Adenine Nucleotides; Amines; Aspirin; Blood Platelet Disorders; Blood Platelets; Carbon Isotopes; Ce	1973
Drugs and children. The New Zealand medical journal, 1968, Volume: 67, Issue:430 Topics: Aminophylline; Aspirin; Atropine; Cardiomyopathies; Cataract; Child, Preschool; Chloramphenicol; Chl	1968
Studies on the detection of adverse drug reactions in the newborn. II. The effects of prenatal aspirin on newborn hemostasis. JAMA, 1970, Sep-21, Volume: 213, Issue:12 Topics: Aspirin; Blood Cell Count; Blood Platelet Disorders; Blood Platelets; Factor XII; Female; Gestationa	1970
Salicylate exposure in the perinate. JAMA, 1969, Jul-28, Volume: 209, Issue:4 Topics: Aspirin; Blood Proteins; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal	1969

aspirin and Infant, Newborn, Diseases

Research Excerpts

Research

Studies (31)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Hastie, R	1
Tong, S	1
Wikström, AK	1
Walker, SP	1
Lindquist, A	1
Cluver, CA	1
Kupka, E	1
Bergman, L	1
Hesselman, S	1
Turner, JM	1
Robertson, NT	1
Hartel, G	1
Kumar, S	1
Xiang, X	1
Wang, F	1
Zhao, N	1
Zhou, Z	1
Streif, W	1
Burdan, F	1
Starosławska, E	1
Szumiło, J	1
Dworzańska, A	1
Dworzański, W	1
Kubiatowski, T	1
Cendrowska-Pinkosz, M	1
Urbańczyk-Zawadzka, M	1
BARNESS, LA	1
YOUNG, LN	1
Dolitzky, M	1
Inbal, A	1
Segal, Y	1
Weiss, A	1
Brenner, B	1
Carp, H	1
Reimann, IW	1
Frölich, JC	1
Niebyl, JR	1
Stuart, MJ	2
Gross, SJ	1
Elrad, H	1
Graeber, JE	1
Rumack, CM	1
Guggenheim, MA	1
Rumack, BH	1
Peterson, RG	1
Johnson, ML	1
Braithwaite, WR	1
Soller, RW	1
Stander, H	1
Rudolph, AM	1
Hauth, JC	1
Goldenberg, RL	1
Parker, CR	1
Cutter, GR	1
Cliver, SP	1
Slone, D	2
Siskind, V	2
Heinonen, OP	2
Monson, RR	2
Kaufman, DW	2
Shapiro, S	2
Sagy, M	1
Birenbaum, E	1
Brish, M	1
Bartel, J	1
Soós, J	1
Várkonyi, P	1
Hartyánszky, I	1
Szabolcs, J	1
Fekete-Farkas, P	1
Lozsádi, K	1
Domula, M	1
Weissbach, G	1
Lenk, H	1
Keller, J	1
Lynd, PA	1
Andreasen, AC	1
Wyatt, RJ	1
de Gaetano, G	1
Donati, MB	1
Garattini, S	1
Yaffe, SJ	1
Miller, JJ	1
Fries, JF	1
Pochedly, C	1
Ente, G	1
Whaun, JM	1
Costello, JM	1
Shannon, FT	1
Bleyer, WA	1
Breckenridge, RT	1
Palmisano, PA	1
Cassady, G	1