aspirin has been researched along with Idiopathic Parkinson Disease in 24 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)." | 7.74 | Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. ( Hancock, DB; Jewett, R; Martin, ER; Scott, BL; Scott, WK; Stacy, MA; Stajich, JM; Vance, JM, 2007) |
| "To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)." | 3.74 | Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. ( Hancock, DB; Jewett, R; Martin, ER; Scott, BL; Scott, WK; Stacy, MA; Stajich, JM; Vance, JM, 2007) |
| "Ibuprofen in isolation was examined in four studies and was associated with a 27% reduction in risk (effect estimate 0." | 2.47 | Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies. ( Ben-Shlomo, Y; Breen, K; Clarke, CE; Ives, N; Patel, S; Rees, K; Stowe, R, 2011) |
| " Coffee drinkers had fewer problems swallowing but dosage and duration of coffee intake were not associated with motor or non-motor symptoms." | 1.91 | Lifestyle factors and clinical severity of Parkinson's disease. ( Gabbert, C; Grünewald, A; Kasten, M; Klein, C; König, IR; Lüth, T; Trinh, J, 2023) |
| "Aspirin treatment also increased the level of phospho-CREB in the nigra of C57/BL6 mice." | 1.51 | Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. ( Dasarathi, S; Jana, M; Pahan, K; Pahan, P; Rangasamy, SB, 2019) |
| "To evaluate the association between type 2 diabetes and newly reported Parkinson's disease." | 1.35 | Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease. ( Buring, JE; Driver, JA; Gaziano, JM; Kurth, T; Logroscino, G; Smith, A, 2008) |
| " Increasing evidence suggests that an inflammatory reaction accompanies the pathological processes caused by Cyclooxygenase (COX) seen in many neurodegenerative disorders, including PD and according to the recent researches chronic use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) decreases the risk of PD in human." | 1.34 | Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease. ( Abid, KM; Ardestani, MS; Hemmati, A; Mehrab, H; Moghaddam, HF; Nazari, Z, 2007) |
| "Nonaspirin NSAID use was associated with a higher risk in women and a lower risk in men." | 1.33 | Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease. ( García Rodríguez, LA; Hernán, MA; Logroscino, G, 2006) |
| "Neuronal death associated with Parkinson's disease is commonly believed to be caused by oxygen- and nitrogen-derived free radical species." | 1.32 | The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds. ( Coates, PW; Everse, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 14 (58.33) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Barua, PD | 1 |
| Dogan, S | 1 |
| Tuncer, T | 1 |
| Baygin, M | 1 |
| Acharya, UR | 1 |
| Gabbert, C | 2 |
| König, IR | 2 |
| Lüth, T | 2 |
| Kolms, B | 1 |
| Kasten, M | 2 |
| Vollstedt, EJ | 1 |
| Balck, A | 1 |
| Grünewald, A | 2 |
| Klein, C | 2 |
| Trinh, J | 2 |
| Xie, Z | 1 |
| Zhou, H | 1 |
| Qiu, Z | 1 |
| Fan, Z | 1 |
| Yang, W | 1 |
| Zhang, J | 1 |
| Wang, Y | 1 |
| Ye, Y | 1 |
| Hsu, CH | 1 |
| Yu, SM | 1 |
| Lau, SC | 1 |
| Chen, YL | 1 |
| Pei, D | 1 |
| Liu, IC | 1 |
| Rangasamy, SB | 1 |
| Dasarathi, S | 1 |
| Pahan, P | 1 |
| Jana, M | 1 |
| Pahan, K | 1 |
| Driver, JA | 1 |
| Smith, A | 1 |
| Buring, JE | 1 |
| Gaziano, JM | 1 |
| Kurth, T | 1 |
| Logroscino, G | 2 |
| Elias, WJ | 1 |
| Sansur, CA | 1 |
| Frysinger, RC | 1 |
| Moghaddam, HF | 1 |
| Hemmati, A | 1 |
| Nazari, Z | 1 |
| Mehrab, H | 1 |
| Abid, KM | 1 |
| Ardestani, MS | 1 |
| Samii, A | 1 |
| Etminan, M | 1 |
| Wiens, MO | 1 |
| Jafari, S | 1 |
| Manthripragada, AD | 1 |
| Schernhammer, ES | 1 |
| Qiu, J | 1 |
| Friis, S | 1 |
| Wermuth, L | 1 |
| Olsen, JH | 1 |
| Ritz, B | 2 |
| Rees, K | 1 |
| Stowe, R | 1 |
| Patel, S | 1 |
| Ives, N | 1 |
| Breen, K | 1 |
| Clarke, CE | 1 |
| Ben-Shlomo, Y | 1 |
| Chen, H | 2 |
| Zhang, SM | 1 |
| Hernán, MA | 2 |
| Schwarzschild, MA | 2 |
| Willett, WC | 1 |
| Colditz, GA | 1 |
| Speizer, FE | 1 |
| Ascherio, A | 2 |
| Everse, J | 1 |
| Coates, PW | 1 |
| Cheng, TI | 1 |
| Cheng, TJ | 1 |
| Chiang, SC | 1 |
| Jacobs, E | 1 |
| McCullough, ML | 1 |
| Calle, EE | 1 |
| Thun, MJ | 1 |
| Ton, TG | 1 |
| Heckbert, SR | 1 |
| Longstreth, WT | 1 |
| Rossing, MA | 1 |
| Kukull, WA | 1 |
| Franklin, GM | 1 |
| Swanson, PD | 1 |
| Smith-Weller, T | 1 |
| Checkoway, H | 1 |
| García Rodríguez, LA | 1 |
| Hancock, DB | 1 |
| Martin, ER | 1 |
| Stajich, JM | 1 |
| Jewett, R | 1 |
| Stacy, MA | 1 |
| Scott, BL | 1 |
| Vance, JM | 1 |
| Scott, WK | 1 |
| Bornebroek, M | 1 |
| de Lau, LM | 1 |
| Haag, MD | 1 |
| Koudstaal, PJ | 1 |
| Hofman, A | 1 |
| Stricker, BH | 1 |
| Breteler, MM | 1 |
| Wahner, AD | 1 |
| Bronstein, JM | 1 |
| Bordelon, YM | 1 |
| Tison, F | 1 |
| Duché, B | 1 |
| Loiseau, P | 1 |
| Gidal, BE | 1 |
| Crismon, ML | 1 |
| Wagner, ML | 1 |
| Fagan, SC | 1 |
| Privitera, MD | 1 |
| Dalmady-Israel, C | 1 |
| Graves, NM | 1 |
| Casper, D | 1 |
| Yaparpalvi, U | 1 |
| Rempel, N | 1 |
| Werner, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Parkinson's, Genes and Environment (PAGE) Study[NCT00367900] | 3,100 participants (Actual) | Observational | 2006-08-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aspirin and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
NSAID use and the risk of Parkinson's disease: systematic review and meta-analysis of observational studies.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Cohort Studies; Confid | 2009 |
Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Neuroprotective Agents; Parkins | 2011 |
[Vascular hemi-parkinson disease].
Topics: Aged; Aspirin; Benserazide; Brain Ischemia; Drug Therapy, Combination; Female; Functional Laterality | 1993 |
Current developments in neurology, Part II: Advances in the pharmacotherapy of Alzheimer disease, Parkinson's disease, and stroke.
Topics: Alzheimer Disease; Anticoagulants; Apomorphine; Aspirin; Cerebrovascular Disorders; Cholinergic Agen | 1996 |
20 other studies available for aspirin and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Novel automated PD detection system using aspirin pattern with EEG signals.
Topics: Algorithms; Aspirin; Electroencephalography; Humans; Parkinson Disease; Quality of Life; Support Vec | 2021 |
Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease.
Topics: Age of Onset; Aspirin; Coffee; Humans; Parkinson Disease; Risk Factors; Smoking | 2022 |
Lifestyle factors and clinical severity of Parkinson's disease.
Topics: Aspirin; Coffee; Humans; Life Style; Parkinson Disease; Tremor | 2023 |
Association between 23 drugs and Parkinson's disease: A two-sample Mendelian randomization study.
Topics: Aspirin; Fibrinolytic Agents; Genome-Wide Association Study; Humans; Mendelian Randomization Analysi | 2023 |
Restless legs syndrome/Willis-Ekbom disease in type 2 diabetes as the initial manifestation of Parkinson's disease and major cardiovascular disease.
Topics: Aged; Amines; Analgesics; Anticonvulsants; Antihypertensive Agents; Antiparkinson Agents; Aspirin; B | 2017 |
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cyclic AMP Re | 2019 |
Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease.
Topics: Adult; Aged; Aspirin; beta Carotene; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabe | 2008 |
Sulcal and ventricular trajectories in stereotactic surgery.
Topics: Anticoagulants; Aspirin; Cerebral Cortex; Cerebral Hemorrhage, Traumatic; Cerebral Ventricles; Deep | 2009 |
Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygena | 2007 |
Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi | 2011 |
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2003 |
The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apomorphine; Aspirin; Brain; Catalysis; Cell Line, Tumor; Dogs | 2004 |
Association of aspirin with eosinophilia in peripheral blood.
Topics: Aged; Antiparkinson Agents; Aspirin; Eosinophilia; Humans; Levodopa; Male; Parkinson Disease; Platel | 2004 |
Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Female; Human | 2005 |
Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi | 2006 |
Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Aspirin; Case-Co | 2006 |
Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Beverages; Caffeine; Case-Control Studies; F | 2007 |
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Cyclooxygenase Inhibitors; F | 2007 |
Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents | 2007 |
Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro.
Topics: Acetaminophen; Animals; Aspirin; Cell Count; Cells, Cultured; Dopamine; Fetus; Glutamic Acid; Ibupro | 2000 |