Page last updated: 2024-10-23

aspirin and Idiopathic Parkinson Disease

aspirin has been researched along with Idiopathic Parkinson Disease in 24 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

ExcerptRelevanceReference
"To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)."7.74Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. ( Hancock, DB; Jewett, R; Martin, ER; Scott, BL; Scott, WK; Stacy, MA; Stajich, JM; Vance, JM, 2007)
"To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)."3.74Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease. ( Hancock, DB; Jewett, R; Martin, ER; Scott, BL; Scott, WK; Stacy, MA; Stajich, JM; Vance, JM, 2007)
"Ibuprofen in isolation was examined in four studies and was associated with a 27% reduction in risk (effect estimate 0."2.47Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies. ( Ben-Shlomo, Y; Breen, K; Clarke, CE; Ives, N; Patel, S; Rees, K; Stowe, R, 2011)
" Coffee drinkers had fewer problems swallowing but dosage and duration of coffee intake were not associated with motor or non-motor symptoms."1.91Lifestyle factors and clinical severity of Parkinson's disease. ( Gabbert, C; Grünewald, A; Kasten, M; Klein, C; König, IR; Lüth, T; Trinh, J, 2023)
"Aspirin treatment also increased the level of phospho-CREB in the nigra of C57/BL6 mice."1.51Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. ( Dasarathi, S; Jana, M; Pahan, K; Pahan, P; Rangasamy, SB, 2019)
"To evaluate the association between type 2 diabetes and newly reported Parkinson's disease."1.35Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease. ( Buring, JE; Driver, JA; Gaziano, JM; Kurth, T; Logroscino, G; Smith, A, 2008)
" Increasing evidence suggests that an inflammatory reaction accompanies the pathological processes caused by Cyclooxygenase (COX) seen in many neurodegenerative disorders, including PD and according to the recent researches chronic use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) decreases the risk of PD in human."1.34Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease. ( Abid, KM; Ardestani, MS; Hemmati, A; Mehrab, H; Moghaddam, HF; Nazari, Z, 2007)
"Nonaspirin NSAID use was associated with a higher risk in women and a lower risk in men."1.33Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease. ( García Rodríguez, LA; Hernán, MA; Logroscino, G, 2006)
"Neuronal death associated with Parkinson's disease is commonly believed to be caused by oxygen- and nitrogen-derived free radical species."1.32The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds. ( Coates, PW; Everse, J, 2004)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (8.33)18.2507
2000's14 (58.33)29.6817
2010's4 (16.67)24.3611
2020's4 (16.67)2.80

Authors

AuthorsStudies
Barua, PD1
Dogan, S1
Tuncer, T1
Baygin, M1
Acharya, UR1
Gabbert, C2
König, IR2
Lüth, T2
Kolms, B1
Kasten, M2
Vollstedt, EJ1
Balck, A1
Grünewald, A2
Klein, C2
Trinh, J2
Xie, Z1
Zhou, H1
Qiu, Z1
Fan, Z1
Yang, W1
Zhang, J1
Wang, Y1
Ye, Y1
Hsu, CH1
Yu, SM1
Lau, SC1
Chen, YL1
Pei, D1
Liu, IC1
Rangasamy, SB1
Dasarathi, S1
Pahan, P1
Jana, M1
Pahan, K1
Driver, JA1
Smith, A1
Buring, JE1
Gaziano, JM1
Kurth, T1
Logroscino, G2
Elias, WJ1
Sansur, CA1
Frysinger, RC1
Moghaddam, HF1
Hemmati, A1
Nazari, Z1
Mehrab, H1
Abid, KM1
Ardestani, MS1
Samii, A1
Etminan, M1
Wiens, MO1
Jafari, S1
Manthripragada, AD1
Schernhammer, ES1
Qiu, J1
Friis, S1
Wermuth, L1
Olsen, JH1
Ritz, B2
Rees, K1
Stowe, R1
Patel, S1
Ives, N1
Breen, K1
Clarke, CE1
Ben-Shlomo, Y1
Chen, H2
Zhang, SM1
Hernán, MA2
Schwarzschild, MA2
Willett, WC1
Colditz, GA1
Speizer, FE1
Ascherio, A2
Everse, J1
Coates, PW1
Cheng, TI1
Cheng, TJ1
Chiang, SC1
Jacobs, E1
McCullough, ML1
Calle, EE1
Thun, MJ1
Ton, TG1
Heckbert, SR1
Longstreth, WT1
Rossing, MA1
Kukull, WA1
Franklin, GM1
Swanson, PD1
Smith-Weller, T1
Checkoway, H1
García Rodríguez, LA1
Hancock, DB1
Martin, ER1
Stajich, JM1
Jewett, R1
Stacy, MA1
Scott, BL1
Vance, JM1
Scott, WK1
Bornebroek, M1
de Lau, LM1
Haag, MD1
Koudstaal, PJ1
Hofman, A1
Stricker, BH1
Breteler, MM1
Wahner, AD1
Bronstein, JM1
Bordelon, YM1
Tison, F1
Duché, B1
Loiseau, P1
Gidal, BE1
Crismon, ML1
Wagner, ML1
Fagan, SC1
Privitera, MD1
Dalmady-Israel, C1
Graves, NM1
Casper, D1
Yaparpalvi, U1
Rempel, N1
Werner, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Parkinson's, Genes and Environment (PAGE) Study[NCT00367900]3,100 participants (Actual)Observational2006-08-21Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for aspirin and Idiopathic Parkinson Disease

ArticleYear
NSAID use and the risk of Parkinson's disease: systematic review and meta-analysis of observational studies.
    Drugs & aging, 2009, Volume: 26, Issue:9

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Cohort Studies; Confid

2009
Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies.
    The Cochrane database of systematic reviews, 2011, Nov-09, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Neuroprotective Agents; Parkins

2011
[Vascular hemi-parkinson disease].
    Revue neurologique, 1993, Volume: 149, Issue:10

    Topics: Aged; Aspirin; Benserazide; Brain Ischemia; Drug Therapy, Combination; Female; Functional Laterality

1993
Current developments in neurology, Part II: Advances in the pharmacotherapy of Alzheimer disease, Parkinson's disease, and stroke.
    The Annals of pharmacotherapy, 1996, Volume: 30, Issue:12

    Topics: Alzheimer Disease; Anticoagulants; Apomorphine; Aspirin; Cerebrovascular Disorders; Cholinergic Agen

1996

Other Studies

20 other studies available for aspirin and Idiopathic Parkinson Disease

ArticleYear
Novel automated PD detection system using aspirin pattern with EEG signals.
    Computers in biology and medicine, 2021, Volume: 137

    Topics: Algorithms; Aspirin; Electroencephalography; Humans; Parkinson Disease; Quality of Life; Support Vec

2021
Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease.
    Journal of neurology, 2022, Volume: 269, Issue:8

    Topics: Age of Onset; Aspirin; Coffee; Humans; Parkinson Disease; Risk Factors; Smoking

2022
Lifestyle factors and clinical severity of Parkinson's disease.
    Scientific reports, 2023, 06-12, Volume: 13, Issue:1

    Topics: Aspirin; Coffee; Humans; Life Style; Parkinson Disease; Tremor

2023
Association between 23 drugs and Parkinson's disease: A two-sample Mendelian randomization study.
    Brain and behavior, 2023, Volume: 13, Issue:11

    Topics: Aspirin; Fibrinolytic Agents; Genome-Wide Association Study; Humans; Mendelian Randomization Analysi

2023
Restless legs syndrome/Willis-Ekbom disease in type 2 diabetes as the initial manifestation of Parkinson's disease and major cardiovascular disease.
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2017, Volume: 17, Issue:6

    Topics: Aged; Amines; Analgesics; Anticonvulsants; Antihypertensive Agents; Antiparkinson Agents; Aspirin; B

2017
Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2019, Volume: 14, Issue:2

    Topics: alpha-Synuclein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cyclic AMP Re

2019
Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease.
    Diabetes care, 2008, Volume: 31, Issue:10

    Topics: Adult; Aged; Aspirin; beta Carotene; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabe

2008
Sulcal and ventricular trajectories in stereotactic surgery.
    Journal of neurosurgery, 2009, Volume: 110, Issue:2

    Topics: Anticoagulants; Aspirin; Cerebral Cortex; Cerebral Hemorrhage, Traumatic; Cerebral Ventricles; Deep

2009
Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease.
    Pakistan journal of biological sciences : PJBS, 2007, Nov-01, Volume: 10, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygena

2007
Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease.
    Neuroepidemiology, 2011, Volume: 36, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi

2011
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease.
    Archives of neurology, 2003, Volume: 60, Issue:8

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspir

2003
The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds.
    Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apomorphine; Aspirin; Brain; Catalysis; Cell Line, Tumor; Dogs

2004
Association of aspirin with eosinophilia in peripheral blood.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:12

    Topics: Aged; Antiparkinson Agents; Aspirin; Eosinophilia; Humans; Levodopa; Male; Parkinson Disease; Platel

2004
Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease.
    Annals of neurology, 2005, Volume: 58, Issue:6

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Female; Human

2005
Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi

2006
Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease.
    Neurology, 2006, Apr-11, Volume: 66, Issue:7

    Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Aspirin; Case-Co

2006
Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease.
    Archives of neurology, 2007, Volume: 64, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Beverages; Caffeine; Case-Control Studies; F

2007
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease.
    Neuroepidemiology, 2007, Volume: 28, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Cyclooxygenase Inhibitors; F

2007
Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease.
    Neurology, 2007, Nov-06, Volume: 69, Issue:19

    Topics: Age of Onset; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents

2007
Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro.
    Neuroscience letters, 2000, Aug-11, Volume: 289, Issue:3

    Topics: Acetaminophen; Animals; Aspirin; Cell Count; Cells, Cultured; Dopamine; Fetus; Glutamic Acid; Ibupro

2000