aspirin has been researched along with Hyperhomocysteinemia in 21 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Hyperhomocysteinemia: Condition in which the plasma levels of homocysteine and related metabolites are elevated (
| Excerpt | Relevance | Reference |
|---|---|---|
| " Approach and Results: The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) randomized patients with acute minor ischemic stroke or high-risk transient ischemic attack to clopidogrel plus aspirin or aspirin alone from October 1, 2009, to July 30, 2012, in China." | 9.34 | Homocysteine Level Predicts Response to Dual Antiplatelet in Women With Minor Stroke or Transient Ischemic Attack: Subanalysis of the CHANCE Trial. ( Li, H; Li, J; Lin, J; Liu, L; Wang, A; Wang, Y; Zhao, X; Zuo, Z, 2020) |
| " Additional subgroup analysis included the presence of hypertension, diabetes, low-density lipoprotein levels, sex, and use of aspirin." | 7.79 | Hyperhomocysteinemia and vascular access thrombosis in hemodialysis patients: a retrospective study. ( El-Charabaty, E; El-Sayegh, S; Saifan, C, 2013) |
| "High total plasma homocysteine (tHcy) is associated with increased risk of cardiovascular events and depression." | 7.78 | Aspirin decreases the risk of depression in older men with high plasma homocysteine. ( Alfonso, H; Almeida, OP; Flicker, L; Hankey, GJ; McCaul, K; Yeap, BB, 2012) |
| "Mild hyperhomocysteinemia is considered a risk factor for development of neurodegenerative diseases." | 5.48 | Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective? ( de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS, 2018) |
| " Approach and Results: The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) randomized patients with acute minor ischemic stroke or high-risk transient ischemic attack to clopidogrel plus aspirin or aspirin alone from October 1, 2009, to July 30, 2012, in China." | 5.34 | Homocysteine Level Predicts Response to Dual Antiplatelet in Women With Minor Stroke or Transient Ischemic Attack: Subanalysis of the CHANCE Trial. ( Li, H; Li, J; Lin, J; Liu, L; Wang, A; Wang, Y; Zhao, X; Zuo, Z, 2020) |
| "We performed a secondary analysis from the Cilostazol in Acute Ischemic Stroke Treatment (CAIST) trial, which was a double-blinded, randomized, multicenter trial, assessing the noninferiority of cilostazol over aspirin within 48 hours of an acute ischemic stroke." | 5.19 | Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke. ( Bae, HJ; Kang, DW; Kwon, HM; Lee, YS, 2014) |
| " Hyperhomocysteinemia is a known determinant of platelet function abnormalities." | 3.96 | Homocysteine levels and platelet reactivity in coronary artery disease patients treated with ticagrelor. ( De Luca, G; Marcolongo, M; Nardin, M; Negro, F; Pergolini, P; Rolla, R; Tonon, F; Verdoia, M, 2020) |
| " Additional subgroup analysis included the presence of hypertension, diabetes, low-density lipoprotein levels, sex, and use of aspirin." | 3.79 | Hyperhomocysteinemia and vascular access thrombosis in hemodialysis patients: a retrospective study. ( El-Charabaty, E; El-Sayegh, S; Saifan, C, 2013) |
| "High total plasma homocysteine (tHcy) is associated with increased risk of cardiovascular events and depression." | 3.78 | Aspirin decreases the risk of depression in older men with high plasma homocysteine. ( Alfonso, H; Almeida, OP; Flicker, L; Hankey, GJ; McCaul, K; Yeap, BB, 2012) |
| "Hyperhomocysteinemia confers an increased risk of coronary artery disease, stroke, and deep vein thrombosis, and is a strong predictor of mortality among patients with ischemic heart disease." | 3.74 | Homocysteine (Hcy) follow-up study. ( Blum, A; Blum, N; Eizenberg, MM; Hijazi, I, 2007) |
| " If thrombophilia was diagnosed on the basis of hyperhomocysteinemia, the treatment consisted of aspirin, pyridoxine and folic acid, instead." | 3.71 | Non-pregnant circulatory volume status predicts subsequent pregnancy outcome in normotensive thrombophilic formerly preeclamptic women. ( Aardenburg, R; de Leeuw, PW; Ekhart, TH; Peeters, LL; Spaanderman, ME; van der Heijden, OW; van Eyck, J; van Eyndhoven, HW, 2001) |
| "Aspirin/dipyridamole was more effective than aspirin therapy in reducing BV at shear rates of 1 s(-1) (-3." | 2.73 | Treatment with aspirin and dipyridamole is more effective than aspirin in reducing low shear blood viscosity. ( Rosenson, RS, 2008) |
| "Venous thromboembolism is a frequent and serious disorder influenced by numerous factors." | 2.42 | Quantification of risk factors for venous thromboembolism: a preliminary study for the development of a risk assessment tool. ( Dahl, OE; Mismetti, P; Quinlan, DJ; Rosencher, N; Samama, MM, 2003) |
| "Mild hyperhomocysteinemia is considered a risk factor for development of neurodegenerative diseases." | 1.48 | Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective? ( de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS, 2018) |
| "Since completion of the recurrent miscarriage analysis, 39 women conceived again." | 1.32 | Pregnancy outcome in patients with a history of recurrent spontaneous miscarriages and documented thrombophilias. ( Dekker, GA; Krabbendam, I, 2004) |
| "Buerger's disease or thromboangiitis obliterans is a disorder of unknown etiology which affects young heavy smokers, mainly of male sex; it is not clear why this disease afflicts only a little number of heavy smokers." | 1.31 | [Aspects of thrombophilia in Buerger's disease]. ( Bambara, LM; Biasi, D; Caramaschi, P; Carletto, A; Volpe, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (61.90) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Verdoia, M | 1 |
| Rolla, R | 1 |
| Negro, F | 1 |
| Tonon, F | 1 |
| Pergolini, P | 1 |
| Nardin, M | 1 |
| Marcolongo, M | 1 |
| De Luca, G | 1 |
| Li, J | 1 |
| Wang, Y | 2 |
| Li, H | 1 |
| Zuo, Z | 1 |
| Lin, J | 1 |
| Wang, A | 1 |
| Zhao, X | 1 |
| Liu, L | 1 |
| de S Moreira, D | 1 |
| Figueiró, PW | 1 |
| Siebert, C | 1 |
| Prezzi, CA | 1 |
| Rohden, F | 1 |
| Guma, FCR | 1 |
| Manfredini, V | 1 |
| Wyse, ATS | 1 |
| Saifan, C | 1 |
| El-Charabaty, E | 1 |
| El-Sayegh, S | 1 |
| Chakraborty, P | 1 |
| Banerjee, S | 1 |
| Saha, P | 1 |
| Nandi, SS | 1 |
| Sharma, S | 1 |
| Goswami, SK | 1 |
| Chakravarty, B | 1 |
| Kabir, SN | 1 |
| Kwon, HM | 1 |
| Lee, YS | 1 |
| Bae, HJ | 1 |
| Kang, DW | 1 |
| Rosenson, RS | 1 |
| Katsi, V | 1 |
| Tousoulis, D | 1 |
| Chatzistamatiou, E | 1 |
| Androulakis, E | 1 |
| Moustakas, G | 1 |
| Skiadas, I | 1 |
| Tsioufis, C | 1 |
| Antoniades, C | 1 |
| Stefanadis, CI | 1 |
| Kallikazaros, IE | 1 |
| Almeida, OP | 1 |
| Flicker, L | 1 |
| Yeap, BB | 1 |
| Alfonso, H | 1 |
| McCaul, K | 1 |
| Hankey, GJ | 1 |
| Bruhn, HD | 1 |
| Arnold, M | 1 |
| Nedeltchev, K | 1 |
| Lyrer, P | 1 |
| Baumgartner, RW | 1 |
| Samama, MM | 1 |
| Dahl, OE | 1 |
| Quinlan, DJ | 1 |
| Mismetti, P | 1 |
| Rosencher, N | 1 |
| Krabbendam, I | 1 |
| Dekker, GA | 1 |
| Grübler, B | 1 |
| Schroecksnadel, K | 1 |
| Frick, B | 1 |
| Winkler, C | 1 |
| Wirleitner, B | 1 |
| Schennach, H | 1 |
| Fuchs, D | 1 |
| Olivier, AC | 1 |
| Hollman, JL | 1 |
| Blinc, A | 1 |
| Poredos, P | 1 |
| Blum, A | 1 |
| Hijazi, I | 1 |
| Eizenberg, MM | 1 |
| Blum, N | 1 |
| Caramaschi, P | 1 |
| Biasi, D | 1 |
| Volpe, A | 1 |
| Carletto, A | 1 |
| Bambara, LM | 1 |
| Spaanderman, ME | 1 |
| Aardenburg, R | 1 |
| Ekhart, TH | 1 |
| van Eyndhoven, HW | 1 |
| van der Heijden, OW | 1 |
| van Eyck, J | 1 |
| de Leeuw, PW | 1 |
| Peeters, LL | 1 |
| Cacoub, P | 1 |
| Sbai, A | 1 |
| Brocheriou, I | 1 |
| Kaloustian, E | 1 |
| Cohen, G | 1 |
| Kieffer, E | 1 |
| Piette, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized,Double-blind Trial Comparing the Effects of a 3-month Clopidogrel Regimen,Combined With ASA During the First 21days,Versus ASA Alone for the Acute Treatment of TIA or Minor Stroke[NCT00979589] | Phase 3 | 5,100 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aspirin and Hyperhomocysteinemia
| Article | Year |
|---|---|
[Stroke prevention].
Topics: Administration, Oral; Aged; Anticoagulants; Antihypertensive Agents; Aspirin; Carotid Stenosis; Cont | 2003 |
Quantification of risk factors for venous thromboembolism: a preliminary study for the development of a risk assessment tool.
Topics: Adult; Aged; Aspirin; Blood Coagulation Factors; Blood Group Antigens; Ethnicity; Gonadal Steroid Ho | 2003 |
Pharmacological prevention of atherothrombotic events in patients with peripheral arterial disease.
Topics: Antihypertensive Agents; Aspirin; Cardiovascular Agents; Diabetic Angiopathies; Humans; Hydroxymethy | 2007 |
3 trials available for aspirin and Hyperhomocysteinemia
| Article | Year |
|---|---|
Homocysteine Level Predicts Response to Dual Antiplatelet in Women With Minor Stroke or Transient Ischemic Attack: Subanalysis of the CHANCE Trial.
Topics: Aged; Aspirin; Biomarkers; China; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Femal | 2020 |
Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke.
Topics: Aged; Aspirin; Biomarkers; Brain Ischemia; C-Reactive Protein; Cilostazol; Disease Progression; Doub | 2014 |
Treatment with aspirin and dipyridamole is more effective than aspirin in reducing low shear blood viscosity.
Topics: Adult; Aged; Aspirin; Blood Viscosity; Cardiovascular Diseases; Dipyridamole; Female; Hematocrit; Hu | 2008 |
15 other studies available for aspirin and Hyperhomocysteinemia
| Article | Year |
|---|---|
Homocysteine levels and platelet reactivity in coronary artery disease patients treated with ticagrelor.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Biomarkers; Dual Anti-Platelet Therapy; F | 2020 |
Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catalase; Cerebral | 2018 |
Hyperhomocysteinemia and vascular access thrombosis in hemodialysis patients: a retrospective study.
Topics: Aged; Aspirin; Biomarkers; Chi-Square Distribution; Diabetes Complications; Female; Fibrinolytic Age | 2013 |
Aspirin and low-molecular weight heparin combination therapy effectively prevents recurrent miscarriage in hyperhomocysteinemic women.
Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Drug Therapy, Combination; Female; Heparin, Low- | 2013 |
A 31 year old woman with essential hypertension grade III and branch retinal vein occlusion with homozygous C677T MTHFR hyperhomocysteinemia and high Lp(a) levels.
Topics: Adult; Antihypertensive Agents; Aspirin; Female; Humans; Hyperhomocysteinemia; Hypertension; Lipopro | 2010 |
Aspirin decreases the risk of depression in older men with high plasma homocysteine.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Aspirin; Australia; Cross-Sectional Studies; Depress | 2012 |
["How must deep leg venous thrombosis be diagnosed and treated?"].
Topics: Anticoagulants; Arthroplasty, Replacement, Hip; Aspirin; Blood Coagulation Tests; Blood Viscosity; F | 2003 |
Pregnancy outcome in patients with a history of recurrent spontaneous miscarriages and documented thrombophilias.
Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Female; Folic Acid; Heparin, Low-M | 2004 |
[Migraine, inflammation, genes. New risk factors for stroke].
Topics: Adult; Arteriosclerosis; Aspirin; C-Reactive Protein; Case-Control Studies; Contraceptives, Oral; Fe | 2003 |
Aspirin downregulates homocysteine formation in stimulated human peripheral blood mononuclear cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Concanavalin A; Down-Regulation; Flow Cytometry; H | 2005 |
Late in-stent thrombosis in a patient with systemic lupus erythematosus and hyperhomocysteinemia while on clopidogrel and aspirin.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Coagulation Disorders; Clopidogrel; Coronary Artery D | 2006 |
Homocysteine (Hcy) follow-up study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Coronary Artery Disease; En | 2007 |
[Aspects of thrombophilia in Buerger's disease].
Topics: Adjuvants, Immunologic; Adult; Angiography; Aspirin; Female; Humans; Hyperhomocysteinemia; Iloprost; | 2000 |
Non-pregnant circulatory volume status predicts subsequent pregnancy outcome in normotensive thrombophilic formerly preeclamptic women.
Topics: Aspirin; Birth Weight; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; HELLP Syndrome | 2001 |
Hyperhomocysteinemia and arterial aneurysm.
Topics: Adult; Aneurysm; Angiography; Aspirin; Brachial Artery; Folic Acid; Hematinics; Humans; Hyperhomocys | 2002 |