aspirin and Hypercoagulability studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
"There is insufficient data on the efficacy of prasugrel and ticagrelor in Korean patients with ST-segment elevation myocardial infarction (STEMI)."	9.20	Comparison of Prasugrel and Ticagrelor Antiplatelet Effects in Korean Patients Presenting With ST-Segment Elevation Myocardial Infarction. ( Cho, YR; Guo, LZ; Jin, CD; Kim, MH; Kim, YD; Lee, YS; Park, JS; Park, K; Park, TH, 2015)
"Adding LMWH to aspirin at < 12 weeks gestation reduces recurrent HD onset < 34 weeks gestation in women with inheritable thrombophilia and prior delivery for HD/SGA <34 weeks."	9.16	Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. ( Bezemer, PD; de Vries, JI; Hague, WM; Joosten, JH; van Pampus, MG, 2012)
"To compare live birth rates in women with recurrent pregnancy loss (RPL) and either autoantibodies or a coagulation abnormality, treated with low molecular weight heparin plus aspirin (LMWH/ASA) or ASA alone, and to place our results in context with other randomized clinical trials (RCT) with similar cohorts."	9.14	Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. ( Barrett, J; Clark, CA; Crowther, MR; Gent, M; Ginsberg, JS; Hawker, GA; Kingdom, JC; Laskin, CA; Spitzer, KA, 2009)
"To determine in women with hereditary thrombophilia whether the use of the combination of low-molecular-weight heparin (LMWH) and aspirin (ASA) is better than ASA alone."	8.93	Low-molecular-weight heparin plus aspirin versus aspirin alone in pregnant women with hereditary thrombophilia to improve live birth rate: meta-analysis of randomized controlled trials. ( Areia, AL; Areia, M; Fonseca, E; Moura, P, 2016)
"Nine studies, including data of 1228 women, were included in the review evaluating the effect of either LMWH (enoxaparin or nadroparin in varying doses) or aspirin or a combination of both, on the chance of live birth in women with recurrent miscarriage, with or without inherited thrombophilia."	8.90	Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. ( de Jong, PG; Di Nisio, M; Goddijn, M; Kaandorp, S; Middeldorp, S, 2014)
"There is a paucity in studies on the efficacy and safety of aspirin and heparin in women with a history of at least two miscarriages without apparent causes other than inherited thrombophilia."	8.85	Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. ( Di Nisio, M; Goddijn, M; Kaandorp, S; Middeldorp, S, 2009)
" This study investigated the effects of anastrozole and antiplatelet therapy (aspirin/clopidogrel cocktail or atopaxar) treatment on the tumour responses of luminal phenotype breast cancer cells and induced hypercoagulation."	8.02	Antiplatelet Therapy Combined with Anastrozole Induces Features of Partial EMT in Breast Cancer Cells and Fails to Mitigate Breast-Cancer Induced Hypercoagulation. ( Augustine, TN; Xulu, KR, 2021)
"In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction."	7.75	The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009)
"In our retrospective study, only pre-treatment with aspirin and clopidogrel was associated with thrombolysis-related intracerebral hemorrhage."	7.75	Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? ( Dzialowski, I; Gahn, G; Hermann, A; Koch, R, 2009)
"To evaluate the benefit of treatment with dalteparin and low-dose aspirin (ASA) in the prevention of obstetric complications in women with inherited thrombophilia."	7.74	Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia. ( David, M; Dubois, E; Leduc, L; Rey, E; Takser, L, 2007)
" Twenty-six patients with coagulation abnormalities: protein S-deficiency, activated protein C (APC) resistance and/or > or =15 ACA GPL and/or MPL had a subsequent pregnancy and were treated with aspirin in combination with LMWH."	7.70	Low-molecular-weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study. ( de Vries, JI; Dekker, GA; Huijgens, PC; Leeda, M; Riyazi, N; van Geijn, HP, 1998)
"Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal."	6.42	Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts. ( Michiels, JJ, 2003)
"The use of prophylactic treatments against thrombophilia becomes necessary in order to increase the live birth rates in women with RPL."	5.56	Thrombophilia associated gene polymorphisms: Does use of medication, including anti-coagulants, minerals or folic acid, prevent the miscarriages? ( Aslan, I; Ozyigit, S; Paul, LT; Tosun, O; Tulay, P, 2020)
"Women with inherited thrombophilia and recurrent miscarriage might benefit from preconceptional antiagreggation with low-dose acetylsalicylic acid (ASA), but concerns about severe adverse reactions may prevent physicians from performing this treatment in patients with ASA hypersensitivity."	5.38	Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage. ( Gaspar, A; Livramento, S; Morais-Almeida, M; Sampaio, G; Santos, N, 2012)
"Screening results for thrombophilia and antithrombotic treatment with enoxaparin, aspirin, or both and pregnancy outcomes."	5.27	The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages. ( Elias, A; Elias, M; Nahas, R; Saliba, W, 2018)
"A total of 55 patients with a history of thrombosis and SPS phenotype were prospectively studied before and after treatment with aspirin and/or clopidogrel."	5.20	Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome. ( García-Chavez, J; Hernández-Reyes, J; Rosales-Padrón, J; Ruiz-Arguelles, A; Ruiz-Argüelles, GJ; Ruiz-Delgado, GJ; Vargas-Espinosa, J; Velázquez-Sánchez-de-Cima, S; Zamora-Ortiz, G, 2015)
"There is insufficient data on the efficacy of prasugrel and ticagrelor in Korean patients with ST-segment elevation myocardial infarction (STEMI)."	5.20	Comparison of Prasugrel and Ticagrelor Antiplatelet Effects in Korean Patients Presenting With ST-Segment Elevation Myocardial Infarction. ( Cho, YR; Guo, LZ; Jin, CD; Kim, MH; Kim, YD; Lee, YS; Park, JS; Park, K; Park, TH, 2015)
"Adding LMWH to aspirin at < 12 weeks gestation reduces recurrent HD onset < 34 weeks gestation in women with inheritable thrombophilia and prior delivery for HD/SGA <34 weeks."	5.16	Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. ( Bezemer, PD; de Vries, JI; Hague, WM; Joosten, JH; van Pampus, MG, 2012)
"To compare live birth rates in women with recurrent pregnancy loss (RPL) and either autoantibodies or a coagulation abnormality, treated with low molecular weight heparin plus aspirin (LMWH/ASA) or ASA alone, and to place our results in context with other randomized clinical trials (RCT) with similar cohorts."	5.14	Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. ( Barrett, J; Clark, CA; Crowther, MR; Gent, M; Ginsberg, JS; Hawker, GA; Kingdom, JC; Laskin, CA; Spitzer, KA, 2009)
" Low-molecular-weight heparin and low-dose aspirin daily during pregnancy were used in 29 selected cases with acquired and inherited thrombophilia."	5.12	Thrombophilia and antithrombotic therapy in women with recurrent spontaneous abortions. ( Deligiannidis, A; Mavridis, P; Mavroudi, A; Papastavrou, T; Parapanissiou, E; Tabakoudis, G; Tabakoudis, P, 2007)
"During a 1-year treatment period, simvastatin, 20 mg/d, produced a sustained reduction of approximately one quarter in low-density lipoprotein cholesterol levels, with no evidence of toxicity, and aspirin, 100 mg/d, did not substantially increase the risk for a major bleeding episode."	5.11	First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. ( Altmann, P; Armitage, J; Baigent, C; Baxter, A; Cairns, HS; Collins, R; Foley, RN; Frighi, V; Kourellias, K; Landray, M; Leaper, C; Ratcliffe, PJ; Rogerson, M; Scoble, JE; Tomson, CR; Warwick, G; Wheeler, DC, 2005)
" Patients with a history of thromboembolism or positive findings for thrombophilia were prescribed LMWH (enoxaparin sodium, 40 mg daily) in combination with low-dose aspirin (100 mg daily) in the first trimester (group 1, n=14) or the second trimester (group 2, n=17); the remaining 15 patients received low-dose aspirin alone (group 3)."	5.09	Low-molecular-weight heparin for thrombophilia in pregnant women. ( Bar, J; Blickstein, D; Cohen-Sacher, B; Hod, M; Lahav, J; Merlob, P, 2000)
"To determine in women with hereditary thrombophilia whether the use of the combination of low-molecular-weight heparin (LMWH) and aspirin (ASA) is better than ASA alone."	4.93	Low-molecular-weight heparin plus aspirin versus aspirin alone in pregnant women with hereditary thrombophilia to improve live birth rate: meta-analysis of randomized controlled trials. ( Areia, AL; Areia, M; Fonseca, E; Moura, P, 2016)
"Nine studies, including data of 1228 women, were included in the review evaluating the effect of either LMWH (enoxaparin or nadroparin in varying doses) or aspirin or a combination of both, on the chance of live birth in women with recurrent miscarriage, with or without inherited thrombophilia."	4.90	Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. ( de Jong, PG; Di Nisio, M; Goddijn, M; Kaandorp, S; Middeldorp, S, 2014)
" Clinical trials have demonstrated that patients with antiphospholipid antibodies and venous thromboembolism should be treated with vitamin K antagonists (warfarin); that ischemic stroke may be treated with aspirin or warfarin; and that women with recurrent pregnancy loss should receive prophylactic-dose heparin and aspirin."	4.85	Antiphospholipid antibody syndrome. ( Lim, W, 2009)
"There is a paucity in studies on the efficacy and safety of aspirin and heparin in women with a history of at least two miscarriages without apparent causes other than inherited thrombophilia."	4.85	Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. ( Di Nisio, M; Goddijn, M; Kaandorp, S; Middeldorp, S, 2009)
"Aspirin has a well established role in the prevention of arterial thrombosis."	4.79	Aspirin in essential thrombocythemia: status quo and quo vadis. ( Bangerter, M; Griesshammer, M; Michiels, JJ; van Vliet, HH, 1997)
" This study investigated the effects of anastrozole and antiplatelet therapy (aspirin/clopidogrel cocktail or atopaxar) treatment on the tumour responses of luminal phenotype breast cancer cells and induced hypercoagulation."	4.02	Antiplatelet Therapy Combined with Anastrozole Induces Features of Partial EMT in Breast Cancer Cells and Fails to Mitigate Breast-Cancer Induced Hypercoagulation. ( Augustine, TN; Xulu, KR, 2021)
"In our retrospective study, only pre-treatment with aspirin and clopidogrel was associated with thrombolysis-related intracerebral hemorrhage."	3.75	Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? ( Dzialowski, I; Gahn, G; Hermann, A; Koch, R, 2009)
"In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction."	3.75	The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009)
", warfarin, anti-platelet agents) to prevent both device thrombosis and thromboembolism."	3.74	Patient with hypofibrinolysis-mediated thromboembolism converted to a hypercoagulable/hyperfibrinolytic state via ventricular assist device placement. ( Ellis, TC; George, JF; Holman, WL; Kirklin, JK; Nielsen, VG; Steenwyk, BL, 2008)
"To evaluate the benefit of treatment with dalteparin and low-dose aspirin (ASA) in the prevention of obstetric complications in women with inherited thrombophilia."	3.74	Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia. ( David, M; Dubois, E; Leduc, L; Rey, E; Takser, L, 2007)
"We studied the effects of ultra-low-dose aspirin (ULDA) as well as those of sc-560 and ns-398, specific COX-1 and COX-2 inhibitors, on induced hemorrhagic time and in a model of laser-induced thrombosis in rats."	3.74	Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition? ( Aguejouf, O; Desplat, V; Doutremepuich, C; Eizayaga, FX, 2007)
"Unfractionated and low-molecular-weight heparin and low-dose aspirin are used for the prevention of pregnancy loss in pregnant women with thrombophilia."	3.72	Effects of low-molecular-weight and unfractionated heparin on trophoblast function. ( Cartwright, JE; Mountfield, S; Quenby, S; Vince, G; Whitley, GS, 2004)
" If thrombophilia was diagnosed on the basis of hyperhomocysteinemia, the treatment consisted of aspirin, pyridoxine and folic acid, instead."	3.71	Non-pregnant circulatory volume status predicts subsequent pregnancy outcome in normotensive thrombophilic formerly preeclamptic women. ( Aardenburg, R; de Leeuw, PW; Ekhart, TH; Peeters, LL; Spaanderman, ME; van der Heijden, OW; van Eyck, J; van Eyndhoven, HW, 2001)
"Heparin prophylaxis at fixed low doses and possibly aspirin could be efficacious in preventing adverse outcomes in women carrying inherited thrombophilia with previous poor obstetric outcomes."	3.71	Preventing adverse obstetric outcomes in women with genetic thrombophilia. ( Brancaccio, V; Colaizzo, D; Di Minno, G; Grandone, E; Margaglione, M; Pavone, G; Sciannamé, N, 2002)
" Twenty-six patients with coagulation abnormalities: protein S-deficiency, activated protein C (APC) resistance and/or > or =15 ACA GPL and/or MPL had a subsequent pregnancy and were treated with aspirin in combination with LMWH."	3.70	Low-molecular-weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study. ( de Vries, JI; Dekker, GA; Huijgens, PC; Leeda, M; Riyazi, N; van Geijn, HP, 1998)
" Aspirin, 75 mg daily was given in addition to enoxaparin to women with antiphospholipid syndrome."	3.70	Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. ( Blumenfeld, Z; Brenner, B; Hoffman, R; Weiner, Z; Younis, JS, 2000)
"Both hypoxemia and a prothrombotic diathesis have been associated with more severe disease and increased risk of death."	2.94	Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study. ( Forleo, GB; Radovanovic, D; Santus, P; Viecca, M, 2020)
"Aspirin and heparin have been shown to have potentially beneficial effects on trophoblast implantation."	2.79	Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage. ( Adam, I; Ashur, BM; Elbareg, AM; Elmahashi, MO; Essadi, FM, 2014)
"TEG-Hypercoagulability is defined as a TEG maximum amplitude above 69 mm."	2.77	Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr ( Johansson, PI; Kofoed, K; Lilleør, NB; Rafiq, S; Steinbrüchel, DA; Stissing, T; Zacho, M, 2012)
"Thrombophilia has been identified in about 50% of women with recurrent miscarriage and thromboprophylaxis has been suggested as an option of treatment."	2.76	Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. ( Bloemenkamp, KW; Helmerhorst, FM; Kaaja, RJ; Lampinen, K; Morin-Papunen, L; Ulander, VM; Visser, J, 2011)
"In women with a history of recurrent miscarriage, the risk of miscarriage in a subsequent pregnancy is about 30% to 40%."	2.74	Use of heparin in women with early and late miscarriages with and without thrombophilia. ( Baumgarten, S; Dörner, T; Kadecki, O; Kiesewetter, H; Monien, S; Salama, A, 2009)
"Documented VTE (including deep vein thrombosis or pulmonary embolism) and unprovoked VTE (no recent surgery, trauma, or cancer diagnosis) were prospectively evaluated, secondary end points of the trial."	2.73	Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. ( Buring, JE; Glynn, RJ; Goldhaber, SZ; Ridker, PM; Zee, RY, 2007)
"Pregnancy is a prothrombotic condition, which can be abnormally exaggerated in women with thrombophilia."	2.72	Inherited thrombophilia and anticoagulant therapy for women with reproductive failure. ( Han, AR; Han, JW; Lee, SK, 2021)
"Eptifibatide was administered as two 180 microg/kg boluses 10 minutes apart followed by a continuous infusion of 2."	2.70	Activated clotting times in the setting of eptifibatide use during percutaneous coronary intervention. ( Ball, SA; Dauerman, HL; Desourdy, MA; Furman, MI; Goldberg, RJ, 2002)
"Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss."	2.66	Understanding and Preventing Placenta-Mediated Pregnancy Complications. ( Blondon, M; Ní Áinle, F; Skeith, L, 2020)
"Treatment of celecoxib with a proton pump inhibitor is safer than treatment with nonselective NSAID and a proton pump inhibitor in high risk gastrointestinal and cardiovascular patients who mostly also take acetylsalicylic acid."	2.52	[Gastrointestinal bleeding]. ( Lanas, Á, 2015)
"Essential thrombocythemia is a chronic myeloproliferative neoplasm characterized by sustained thrombocytosis, bone marrow megakaryocytic hyperplasia and an increased risk of thrombosis and hemorrhage."	2.49	[Treatment of essential thrombocythemia]. ( Alvarez-Larrán, A; Besses, C; Cervantes, F, 2013)
"Treatment with busulfan or interferon-α is usually effective in hydroxyurea failures."	2.48	Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management. ( Tefferi, A, 2012)
"The optimum treatment for patients with recurrent miscarriage and a confirmed thrombophilia remains a contentious issue."	2.48	Recurrent miscarriage and thrombophilia: an update. ( Dawood, F; Farquharson, R; McNamee, K, 2012)
" In order to achieve the desired results and, as with all medications, PPIs should always be used appropriately taking care never to exceed correct dosage and duration."	2.47	Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections. ( Ferraccioli, GF; Gremese, E; Laria, A; Zoli, A, 2011)
"Age and history of thrombosis are the criteria used to stratify patients to the most appropriate therapeutic options."	2.46	JAK2 mutation and thrombosis in the myeloproliferative neoplasms. ( Vannucchi, AM, 2010)
"Having eliminated the common entity polycythemia vera, further direction for investigation is guided by the erythropoietin level."	2.45	Idiopathic erythrocytosis: a disappearing entity. ( McMullin, MF, 2009)
" Due to lack of complete randomized investigation about the inclusion of antithrombotic prophylaxis in this group of pregnant women, common scheme of administration and optimal dosage is yet to be established."	2.44	[Inherited thrombophilia in women with recurrent miscarriages and pregnancy loss in anamnesis--own experience]. ( Drews, K; Kaluba-Skotarczak, A; Puacz, P; Seremak-Mrozikiewicz, A, 2008)
"The antiphospholipid syndrome is an antibody mediated hypercoagulable state characterized by recurrent venous and arterial thromboembolic events."	2.44	[The antiphospholipid syndrome, an update]. ( Alonso Santor, JE; Inglada Galiana, L; Pérez Paredes, G, 2007)
"The metabolic syndrome is a clustering of risk factors including central obesity, insulin resistance, dyslipidaemia and hypertension."	2.43	Dyslipidaemia, hypercoagulability and the metabolic syndrome. ( Athyros, VG; Kakafika, AI; Karagiannis, A; Liberopoulos, EN; Mikhailidis, DP, 2006)
"Women with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are subject to several complications during pregnancy, including reactivation of SLE, thrombosis, miscarriage, neonatal lupus, pregnancy-induced hypertension, pulmonary hypertension and drug toxicity."	2.43	[Systematic lupus erythematosus and antiphospholipid syndrome during pregnancy]. ( Khamashta, MA; Ruiz-Irastorza, G, 2006)
"It is rare to see type 2 diabetes, dyslipidemia, obesity or hypertension in isolation."	2.43	Metabolic syndrome. ( Agarwal, PK; Gogia, A, 2006)
"The risk of preeclampsia and placental insufficiency was substantial and occurred in 50% of patients."	2.42	Antiphospholipid syndrome in obstetrics. ( Heilmann, L; Pollow, K; von Tempelhoff, GF, 2003)
"Venous thromboembolism is a frequent and serious disorder influenced by numerous factors."	2.42	Quantification of risk factors for venous thromboembolism: a preliminary study for the development of a risk assessment tool. ( Dahl, OE; Mismetti, P; Quinlan, DJ; Rosencher, N; Samama, MM, 2003)
"Recently, the thrombophilias have been revealed as risk factors for severe preeclampsia, abruptio placentae, fetal growth retardation, abortion and still birth as well."	2.42	[Anticoagulation and antiaggregation during pregnancy]. ( Biasiutti, FD; Strebel, JK, 2003)
"Aspirin, which was regarded as the drug of choice for the prevention of such obstetric complications, has proved to be ineffective in a large clinical trial."	2.42	Inherited thrombophilia and gestational vascular complications. ( Eldor, A; Kupferminc, MJ, 2003)
"Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal."	2.42	Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts. ( Michiels, JJ, 2003)
"The use of prophylactic treatments against thrombophilia becomes necessary in order to increase the live birth rates in women with RPL."	1.56	Thrombophilia associated gene polymorphisms: Does use of medication, including anti-coagulants, minerals or folic acid, prevent the miscarriages? ( Aslan, I; Ozyigit, S; Paul, LT; Tosun, O; Tulay, P, 2020)
"control)."	1.48	Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis. ( Akinshina, S; Bitsadze, V; Khamani, N; Khizroeva, J; Makatsariya, A, 2018)
"Genetic thrombophilia was detected in 13% of patients."	1.43	The role of coagulation disorders in patients with retinal vein occlusion. ( Hernández, JL; Napal, JJ; Neila, S; Pérez-Montes, R; Ruiz, S; Sierra, I, 2016)
"Hypercoagulability was identified in 17 (68%) patients."	1.40	[Hypercoagulation syndrome in multiple myeloma]. ( Gemdzhian, ÉG; Gracheva, MA; Mendeleeva, LP; Pokrovskaia, OS; Tarandovskiĭ, ID; Urnova, ES; Vasil'ev, SA, 2014)
"The syndrome was recognized as a distinct disorder in 1983 by Holiday and further characterized in the 1980s and 1990s, with Mammen and Bick providing the key findings."	1.40	Sticky platelet syndrome: history and future perspectives. ( Holly, P; Kubisz, P; Ruiz-Argüelles, GJ; Ruiz-Delgado, GJ; Stasko, J, 2014)
"Thromboembolism is an infrequent, yet serious cause of both maternal and fetal morbidity and death during pregnancy and the puerperium."	1.38	Anticoagulant therapy during pregnancy for maternal and fetal acquired and inherited thrombophilia. ( Giannubilo, SR; Tranquilli, AL, 2012)
"Women with inherited thrombophilia and recurrent miscarriage might benefit from preconceptional antiagreggation with low-dose acetylsalicylic acid (ASA), but concerns about severe adverse reactions may prevent physicians from performing this treatment in patients with ASA hypersensitivity."	1.38	Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage. ( Gaspar, A; Livramento, S; Morais-Almeida, M; Sampaio, G; Santos, N, 2012)
"Mechanical valve thrombosis is a rare condition in an adequately anticoagulated patient in the absence of underlying thrombophilia."	1.37	Anticoagulant-resistant thrombophilia in a patient with polycythemia vera: a case report. ( Cherian, SV; Das, S; Gajra, A; Garcha, AS; Jasti, S; Karachiwala, H, 2011)
"The optimal treatment of thrombophilias consists of oral (warfarin) or injectable (heparins) anticoagulants."	1.37	Some considerations about the hypercoagulable states and their treatments. ( Cacciapuoti, F, 2011)
"Aspirin resistance was defined as having a closure time of less than 186 s with Col/Epi cartridges despite regular aspirin therapy."	1.36	Impact of genetic polymorphisms on platelet function and aspirin resistance. ( Hancer, V; Nisanci, Y; Oflaz, H; Onur, I; Pamukcu, B; Yavuz, S, 2010)
"Since completion of the recurrent miscarriage analysis, 39 women conceived again."	1.32	Pregnancy outcome in patients with a history of recurrent spontaneous miscarriages and documented thrombophilias. ( Dekker, GA; Krabbendam, I, 2004)
"Among the patients treated (n = 38) thrombophilia screening was positive in 16 patients and in the remaining 22 no causative factor was detected."	1.31	Thromboprophylaxis throughout pregnancy in women with previous history of recurrent miscarriages of unknown aetiology. ( Anapliotis, A; Klearchou, N; Loufopoulos, A; Mamopoulos, A; Mamopoulos, M; Psarra, A; Tzafettas, J, 2002)
"Buerger's disease or thromboangiitis obliterans is a disorder of unknown etiology which affects young heavy smokers, mainly of male sex; it is not clear why this disease afflicts only a little number of heavy smokers."	1.31	[Aspects of thrombophilia in Buerger's disease]. ( Bambara, LM; Biasi, D; Caramaschi, P; Carletto, A; Volpe, A, 2000)

Research

Studies (194)

Authors

Clinical Trials (12)

Trial Overview

Trial Outcomes

Whole Blood Coagulation

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (5.67)	18.2507
2000's	97 (50.00)	29.6817
2010's	71 (36.60)	24.3611
2020's	15 (7.73)	2.80

Authors	Studies
Sung, N	1
Khan, SA	1
Yiu, ME	1
Jubiz, G	1
Salazar, MD	1
Skariah, A	1
Dambaeva, S	1
Kwak-Kim, J	2
Ankola, AA	1
Bradford, VR	1
Newburger, JW	1
Emani, S	1
Dionne, A	1
Friedman, K	1
Son, MB	1
Henderson, LA	1
Lee, PY	1
Hellinger, A	1
Hawkins, B	1
Ventresco, C	1
Esteso, P	1
VanderPluym, CJ	1
Chen, S	1
Jiang, W	1
Wang, J	1
Sabouni, R	1
Gorra Al Nafouri, M	1
Hanafi, I	1
Al Droubi, I	1
Alhalabi, M	1
Yin, M	1
Qin, X	1
Bao, SH	1
Chigirin, N	1
Hoch, V	1
Ahmed, H	1
Frempong, ST	1
Zhang, M	1
Ruan, JL	1
Karadağ, C	1
Akar, B	1
Gönenç, G	1
Aslancan, R	1
Yılmaz, N	1
Çalışkan, E	1
Viecca, M	1
Radovanovic, D	1
Forleo, GB	1
Santus, P	1
Aslan, I	1
Ozyigit, S	1
Paul, LT	1
Tosun, O	1
Tulay, P	1
Skeith, L	2
Blondon, M	1
Ní Áinle, F	1
Kuroda, K	1
Matsumura, Y	1
Ikemoto, Y	1
Segawa, T	1
Hashimoto, T	1
Fukuda, J	1
Nakagawa, K	1
Uchida, T	1
Ochiai, A	1
Horimoto, Y	1
Arakawa, A	1
Nojiri, S	1
Itakura, A	1
Sugiyama, R	1
Han, AR	1
Han, JW	1
Lee, SK	2
Kim, J	1
Jang, HJ	1
Schellingerhout, D	1
Kim, H	1
Kim, YD	2
Lee, KY	1
Choi, HY	1
Cho, HJ	1
Jang, SS	1
Jeon, S	1
Kwon, IC	1
Kim, K	1
Ryu, WS	1
Nahrendorf, M	1
Choi, S	1
Kim, DE	1
Gangat, N	2
Tefferi, A	3
Szuber, N	1
Pardanani, A	1
Hanson, CA	1
Vannucchi, AM	2
Barbui, T	1
Xulu, KR	1
Augustine, TN	1
Calhoun, B	1
Hoover, E	1
Seybold, D	1
Broce, M	1
Hill, A	1
Schaible, B	1
Bracero, LA	1
Kelly, RI	1
Wee, E	1
Tancharoen, C	1
Tam, MM	1
Balta, S	1
Williams, RA	1
Lippi, G	1
Cervellin, G	1
Akinshina, S	1
Makatsariya, A	1
Bitsadze, V	1
Khizroeva, J	1
Khamani, N	1
Kwiatkowski, J	1
Halupczok-Żyła, J	1
Bolanowski, M	1
Kuliszkiewicz-Janus, M	1
Wernly, B	1
Lichtenauer, M	1
Hoppe, UC	1
Lauten, A	1
Navarese, EP	1
Jung, C	1
Santos, N	1
Gaspar, A	1
Livramento, S	1
Sampaio, G	1
Morais-Almeida, M	1
Lavi, N	1
Brenner, B	2
Avivi, I	1
Fallahi, P	1
Katz, R	1
Toma, I	1
Li, R	1
Reiner, J	1
VanHouten, K	1
Carpio, L	1
Marshall, L	1
Lian, Y	1
Bupp, S	1
Fu, SW	1
Rickles, F	1
Leitenberg, D	1
Lai, Y	1
Weksler, BB	1
Rebling, F	1
Yang, Z	1
McCaffrey, TA	1
Alvarez-Larrán, A	1
Cervantes, F	1
Besses, C	1
Kim, SJ	1
Bang, OY	1
Velázquez-Sánchez-de-Cima, S	1
Zamora-Ortiz, G	1
Hernández-Reyes, J	1
Vargas-Espinosa, J	1
García-Chavez, J	1
Rosales-Padrón, J	1
Ruiz-Delgado, GJ	2
Ruiz-Arguelles, A	1
Ruiz-Argüelles, GJ	2
Prandoni, P	1
Barbar, S	1
Milan, M	1
Vedovetto, V	1
Pesavento, R	1
Chapin, J	1
Carlson, K	1
Christos, PJ	1
DeSancho, MT	1
Diez-Ewald, M	1
Elmahashi, MO	1
Elbareg, AM	1
Essadi, FM	1
Ashur, BM	1
Adam, I	1
Kubisz, P	1
Stasko, J	1
Holly, P	1
Grandone, E	3
Villani, M	2
Dentali, F	1
Tiscia, GL	2
Colaizzo, D	2
Cappucci, F	1
Fischetti, L	1
Ageno, W	1
Margaglione, M	2
de Jong, PG	2
Kaandorp, S	2
Di Nisio, M	2
Goddijn, M	3
Middeldorp, S	3
Castillo-Martínez, C	1
Moncada, B	1
Valdés-Rodríguez, R	1
González, FJ	1
Mutlu, I	1
Mutlu, MF	1
Biri, A	1
Bulut, B	1
Erdem, M	1
Erdem, A	1
Urnova, ES	1
Pokrovskaia, OS	1
Gracheva, MA	1
Vasil'ev, SA	1
Gemdzhian, ÉG	1
Tarandovskiĭ, ID	1
Mendeleeva, LP	1
Gallice, M	1
Rouberol, F	1
Albaladejo, P	1
Brillat Zaratzian, E	1
Palombi, K	1
Aptel, F	1
Romanet, JP	1
Chiquet, C	1
Aguilar, C	1
Patil, R	1
Ghosh, K	1
Damania, K	1
Bansal, V	1
Satoskar, P	1
Darekar, A	1
Shetty, S	1
Lee, YS	1
Jin, CD	1
Kim, MH	1
Guo, LZ	1
Cho, YR	1
Park, K	1
Park, JS	1
Park, TH	1
Napal, JJ	1
Neila, S	1
Pérez-Montes, R	1
Sierra, I	1
Ruiz, S	1
Hernández, JL	1
Capodanno, D	1
Musumeci, G	1
Lettieri, C	1
Limbruno, U	1
Senni, M	1
Guagliumi, G	1
Valsecchi, O	1
Angiolillo, DJ	1
Rossini, R	1
Abheiden, C	1
Van Hoorn, ME	1
Hague, WM	2
Kostense, PJ	1
van Pampus, MG	2
de Vries, J	1
Areia, AL	1
Fonseca, E	1
Areia, M	1
Moura, P	1
Blann, AD	1
Skjøth, F	1
Rasmussen, LH	1
Larsen, TB	2
Lip, GY	3
Siasos, G	1
Oikonomou, E	1
Zaromitidou, M	1
Kioufis, S	1
Kokkou, E	1
Mourouzis, K	1
Vlasis, K	1
Vavuranakis, M	1
Stone, PH	1
Papavassiliou, AG	1
Tousoulis, D	1
Dimitrova, V	1
Dimitrov, R	1
Savov, A	1
Lanas, Á	1
Smilowitz, NR	1
Berger, JS	1
Qamar, A	1
Bhatt, DL	1
Wang, L	1
Bi, Y	1
Cao, M	1
Ma, R	1
Wu, X	1
Zhang, Y	2
Ding, W	1
Liu, Y	1
Yu, Q	1
Jiang, H	1
Sun, Y	1
Tong, D	1
Guo, L	1
Dong, Z	1
Tian, Y	1
Kou, J	1
Shi, J	1
Nahas, R	1
Saliba, W	1
Elias, A	1
Elias, M	1
Roumi, JE	1
Moukhadder, HM	1
Graziadei, G	1
Pennisi, M	1
Cappellini, MD	1
Taher, AT	1
Rodger, M	1
Bates, SM	1
Greer, IA	1
Pabinger, I	1
Sofaer, S	1
Hirsh, J	1
Nielsen, VG	1
Kirklin, JK	1
Holman, WL	1
George, JF	1
Ellis, TC	1
Steenwyk, BL	1
Seremak-Mrozikiewicz, A	1
Drews, K	1
Puacz, P	1
Kaluba-Skotarczak, A	1
Lee, R	1
Laskin, CA	1
Spitzer, KA	1
Clark, CA	1
Crowther, MR	1
Ginsberg, JS	1
Hawker, GA	1
Kingdom, JC	1
Barrett, J	1
Gent, M	1
Ozçakar, L	1
Dönmez, G	1
Yörübulut, M	1
Aydog, ST	1
Demirel, H	1
Pasaoglu, I	1
Doral, MN	1
Estilita, J	1
Alonso, FM	1
Brasil, JS	1
Baptista, MS	1
Green, DL	1
Karpatkin, S	1
Christensen, TD	1
Jensen, C	1
Christiansen, K	1
Sørensen, B	1
Hermann, A	1
Dzialowski, I	1
Koch, R	1
Gahn, G	1
Shah, N	1
DeLeon, D	1
Schwiebert, LP	1
Mold, JW	1
Acikel, S	1
Yildirir, A	1
Aydinalp, A	1
Bal, U	1
Kaynar, G	1
Ozin, B	1
Muderrisoglu, H	1
Krüger, K	1
Salomon, O	1
Dulitzky, M	2
Apter, S	1
Monien, S	1
Kadecki, O	1
Baumgarten, S	1
Salama, A	1
Dörner, T	1
Kiesewetter, H	1
Kurosawa, H	1
Okuya, M	1
Matsushita, T	1
Kubota, T	1
Endoh, K	1
Kuwashima, S	1
Hagisawa, S	1
Sato, Y	1
Fukushima, K	1
Sugita, K	1
Okada, Y	1
Park, MJ	1
Hayashi, Y	1
Arisaka, O	1
Ghisdal, L	1
Broeders, N	1
Wissing, KM	1
Saidi, A	1
Bensalem, T	1
Mbaba Mena, J	1
Lemy, A	1
Wijns, W	1
Pradier, O	1
Hoang, AD	1
Mikhalski, D	1
Donckier, V	1
Cochaux, P	1
El Housni, H	1
Abramowicz, M	1
Vereerstraeten, P	1
Abramowicz, D	1
Healey, JS	1
Apostolakis, S	1
Shantsila, E	1
Lane, DA	1
Pamukcu, B	2
Oflaz, H	2
Onur, I	1
Hancer, V	1
Yavuz, S	1
Nisanci, Y	2
Lim, W	2
Metjian, A	1
Beer, PA	1
Green, AR	2
McMullin, MF	1
Cardona, R	1
Ramírez, RH	1
Reina, Z	1
Escobar, MF	1
Morales, E	1
Albanese, A	1
Esposito, G	1
Puca, A	1
Tuttolomondo, A	1
Tirpakova, B	1
Di Giuda, D	1
Maira, G	1
Di Lazzaro, V	1
Landolfi, R	2
Nicolazzi, MA	1
Porfidia, A	1
Di Gennaro, L	2
Kosar, A	1
Kasapoglu, B	1
Kalyoncu, S	1
Turan, H	1
Balcik, OS	1
Gümüs, EI	1
Visser, J	1
Ulander, VM	1
Helmerhorst, FM	1
Lampinen, K	1
Morin-Papunen, L	1
Bloemenkamp, KW	1
Kaaja, RJ	1
Kozuma, K	1
Ota, Y	1
Nagai, Y	1
Katsuta, Y	1
Nozaki, E	1
Onodera, T	1
Ikari, Y	1
Kotani, J	1
Kyo, E	1
Yokoi, H	1
Nakamura, M	1
Gris, JC	2
Cacciapuoti, F	1
Ismail, SK	1
Higgins, JR	1
Laria, A	1
Zoli, A	1
Gremese, E	1
Ferraccioli, GF	1
Tchan, M	1
Sillence, D	1
Das, S	1
Karachiwala, H	1
Cherian, SV	1
Garcha, AS	1
Jasti, S	1
Gajra, A	1
Cardona, L	1
Ana, G	1
Luísa, B	1
Leal, A	1
António, F	1
Lídia, S	1
Cruz, FR	1
de Vries, JI	2
Bezemer, PD	1
Joosten, JH	1
Marinov, B	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Dynamics of Hemostatic Parameters in COVID-19 and Comparison of Intervention Strategies Through Adaptive Clinical Trial[NCT04466670]	Phase 2	379 participants (Anticipated)	Interventional	2020-07-11	Recruiting
Genotypic and Phenotypic Correlates of Resistance to Anti-platelet Actions of Aspirin in an At-risk Patient Population and in the General Population[NCT01361620]		190 participants (Actual)	Interventional	2007-12-31	Completed
Low Dose Aspirin and Low-molecular-weight Heparin in the Treatment of Pregnant Libyan Women With Recurrent Miscarriage[NCT01917799]	Phase 4	150 participants (Anticipated)	Interventional	2009-01-31	Recruiting
Hydroxychloroquine in Unexplained Recurrent Pregnancy Loss ,Double Blinded Randomized Controlled Trial .[NCT05237843]	Phase 1	70 participants (Anticipated)	Interventional	2022-03-01	Not yet recruiting
Comparison of Prasugrel and Ticagrelor Antiplatelet Effects in Korean Patients Presenting With ST-segment Elevation Myocardial Infarction[NCT02075125]	Phase 3	39 participants (Actual)	Interventional	2014-01-31	Terminated (stopped due to Enrolling participants has halted prematurely and will not resume)
Management of Antiplatelet Regimen During Surgical Procedures (MARS Registry)[NCT03981835]		1,492 participants (Anticipated)	Observational [Patient Registry]	2019-08-01	Recruiting
The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery in Patients at a High Risk of Cardiac Events[NCT05733208]		766 participants (Anticipated)	Interventional	2023-05-06	Recruiting
Thromboelastography to Assess Age-Related Coagulation Differences in Patients Undergoing Elective Cesarean Delivery.[NCT01416454]		46 participants (Actual)	Observational	2010-10-31	Completed
ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery(TEG-CABG Trial):Does Intensified Postoperative Antiplatelet Therapy in Preoperatively Identified Hypercoagulable Patients Improve Outcome After CABG[NCT01046942]	Phase 3	250 participants (Anticipated)	Interventional	2008-11-30	Recruiting
Study of Heart and Renal Protection (SHARP): The Effects of Lowering LDL-cholesterol With Simvastatin 20mg Plus Ezetimibe 10mg in Patients With Chronic Kidney Disease: a Randomized Placebo-controlled Trial[NCT00125593]	Phase 4	9,438 participants (Actual)	Interventional	2003-06-30	Completed
[NCT00000614]	Phase 3	0 participants	Interventional	1998-09-30	Completed
Induction of Labor at Term Versus Expectant Management Among Women With Abnormal Maternal Serum Biochemical Markers: A Randomized Controlled Trial[NCT02754635]		320 participants (Anticipated)	Interventional	2016-03-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Whole blood coagulation after stimulation with arachidonic acid, as measured in the VerifyNow Aspirin system (Accumetrics). Aspirin response units (ARU) are the residual coagulation present in patients taking aspirin. The higher the ARU, the greater residual coagulation (resistance) to the aspirin effect. (NCT01361620)
Timeframe: Single measurement at 7-10 days after beginning aspirin

Adverse Drug Reaction

Intervention	Aspirin response units (ARU) (Mean)
Aspirin	453.8

Any adverse reaction related to study drug until 30 days after percutaneous coronary intervention. (NCT02075125)
Timeframe: 30 days

Bleeding Event

Intervention	participants (Number)
Prasugrel	0
Ticagrelor	0

Any event related to bleeding including access site bleeding and peri-procedural bleeding based on Bleeding Academic Research Consortium (BARC) criteria. (NCT02075125)
Timeframe: 30 days

Major Adverse Cardiac and Cerebrovascular Events

Intervention	participants (Number)
Prasugrel	0
Ticagrelor	0

Any major adverse cardiac and cerebrovascular event including (death, myocardial infarction, or revascularization and stroke) until day 30. (NCT02075125)
Timeframe: 30 days

Pre-procedure P2Y12 Reaction Units (PRU)

Intervention	participants (Number)
Prasugrel	0
Ticagrelor	0

Platelet reactivity was measured using VerifyNow (volumetrics accuretic, San Diego, California, USA). Platelet reactivity values were presented as P2Y12 reaction units (PRU). (NCT02075125)
Timeframe: Baseline

Pre-procedure Platelet Reactivity Index (PRI)

Intervention	PRU units (Median)
Prasugrel	259
Ticagrelor	261

Platelet reactivity was measured using vasodilator-stimulated phosphoprotein (VASP) phosphorylation P2Y12 assay. Platelet reactivity values were presented as platelet reactivity index (PRI). (NCT02075125)
Timeframe: Baseline

Number of Participants With High Platelet Reactivity

Intervention	percentage (Median)
Prasugrel	51.2
Ticagrelor	47.5

Platelet reactivity were measured by VerifyNow (volumetrics accuretic，San Diego, California, USA), and vasodilator-stimulated phosphoprotein (VASP) phosphorylation P2Y12 assay (BioCytex, Marseille, France) with FACSCalibur flow cytometer (BD Biosciences, San Jose, California, USA) using. Measurement time gap +/- 12 hours were allowed. High platelet reactivity (HPR) is defined as the result of P2Y12 reaction units (PRU) >235 and platelet reactivity index (PRI) >50%. (NCT02075125)
Timeframe: 48 hours after loading dose of study drug

Number of Participants With Low Platelet Reactivity

Intervention	participants (Number)
	PRU>235	VASP-PRI>50%
Prasugrel	0	0
Ticagrelor	0	0

Platelet reactivity were measured using VerifyNow (volumetrics accuretic, San Diego, California, USA), and vasodilator-stimulated phosphoprotein (VASP) phosphorylation P2Y12 assay (BioCytex, Marseille, France) with FACSCalibur flow cytometer (BD Biosciences, San Jose, California, USA) using. Measurement time gap +/- 12 hours were allowed. Low platelet reactivity (LPR) is defined as the result of P2Y12 reaction units (PRU) <85 and platelet reactivity index (PRI)<16%. The PRU value for LPR, 18 patients were in prasugrel groups and 19 patients in ticagrelor groups, regarding the PRI value for LPR, 16 patients were in each groups. (NCT02075125)
Timeframe: 48 hours after loading dose of study drug

Coronary or Non-coronary Revascularization Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Intervention	participants (Number)
	PRU<85	VASP-PRI<16%
Prasugrel	18	16
Ticagrelor	19	16

Revascularization included any arterial revascularization procedure, whether surgical or percutaneous, but excluded revascularization performed for hemodialysis vascular access (e.g. fistuloplasty) or to the donor kidney transplant artery. Revascularization included amputations for vascular disease (rather than for trauma or infection). All potential revascularization events (including angiography) were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

End-stage Renal Disease Among All Patients Not on Dialysis at the Time of Randomization to Simvastatin Plus Ezetimibe Versus Placebo

Intervention	participants (Number)
Simvastatin Plus Ezetimibe	284
Placebo	352

End-stage renal disease was defined as initiation of maintenance dialysis or renal transplantation. Temporary dialysis was excluded. All potential dialysis and transplant events were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Key Outcome as Per Statistical Analysis Plan = Major Atherosclerotic Events Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Intervention	participants (Number)
Simvastatin Plus Ezetimibe	1057
Placebo	1084

Major atherosclerotic events defined as non-fatal myocardial infarction or coronary death, non-hemorrhagic stroke, or any arterial revascularization procedure (excluding dialysis access procedures). Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Major Coronary Events Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Intervention	participants (Number)
Simvastatin Plus Ezetimibe	526
Placebo	619

Major coronary events defined as coronary death or non-fatal myocardial infarction. Myocardial infarction adjudicated based on the presence of serial changes in cardiac biomarkers (e.g. troponin, creatine kinase), typical ECG changes and typical cardiac symptoms. If myocardial infarction was fatal and post-mortem examination findings were available, this information was also assessed. All potential coronary events were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Major Vascular Events Analyzed Among All Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Intervention	participants (Number)
Simvastatin Plus Ezetimibe	213
Placebo	230

Major vascular events defined as non-fatal myocardial infarction or cardiac death, any stroke, or any arterial revascularization procedure (excluding dialysis access procedures). Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Major Vascular Events Analyzed Amongst Patients Initially Randomized to Simvastatin Plus Ezetimibe Versus Placebo (Original Protocol-defined Primary Outcome)

Intervention	participants (Number)
Simvastatin Plus Ezetimibe	701
Placebo	814

Non-hemorrhagic Stroke Among All of Patients Ever Randomized to Simvastatin Plus Ezetimibe Versus All Patients Allocated to Placebo

Intervention	participants (Number)
Simvastatin Plus Ezetimibe	639
Placebo	749

Stroke was defined as rapid onset of focal or global neurological deficit, with duration greater than 24 hours. Clinical notes and brain imaging were sought to determine the stroke etiology, and if the stroke was fatal and post-mortem examination findings were available, this information was also assessed. All potential stroke events (including transient ischemic attack and intracerebral hemorrhage) were adjudicated, using pre-specified objective criteria, by clinicians blinded to study treatment allocation and lipid levels. Numbers provided = number of patients with events. (NCT00125593)
Timeframe: Median follow-up 4.9 years

Article	Year
Meta-Analysis of the Efficacy of Low Molecular Weight Heparin and Aspirin in the Treatment of Thrombosis During Pregnancy and Effects on Coagulation Function. Discovery medicine, 2023, 04-01, Volume: 35, Issue:175 Topics: Anticoagulants; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Pregnancy; Thrombophilia; Th	2023
Understanding and Preventing Placenta-Mediated Pregnancy Complications. Hamostaseologie, 2020, Volume: 40, Issue:3 Topics: Abruptio Placentae; Adult; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome;	2020
Inherited thrombophilia and anticoagulant therapy for women with reproductive failure. American journal of reproductive immunology (New York, N.Y. : 1989), 2021, Volume: 85, Issue:4 Topics: Abortion, Habitual; Anticoagulants; Aspirin; Blood Coagulation; Female; Heparin; Humans; Infertility	2021
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations. American journal of hematology, 2021, 03-01, Volume: 96, Issue:3 Topics: Abortion, Habitual; Abortion, Spontaneous; Anticoagulants; Aspirin; Combined Modality Therapy; Femal	2021
Extreme thrombocytosis in low-risk essential thrombocythemia: Retrospective review of vascular events and treatment strategies. American journal of hematology, 2021, 06-01, Volume: 96, Issue:6 Topics: Adolescent; Adult; Aspirin; Calreticulin; Disease-Free Survival; Erythrocyte Transfusion; Female; Fo	2021
The pathogenesis and available prevention options in patients with diabetic thrombophilia. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2018, Volume: 27, Issue:10 Topics: Aspirin; Blood Coagulation; Diabetes Mellitus; Fibrinolysis; Humans; Hypoglycemic Agents; Thrombophi	2018
Triple therapy: worth the risk? Minerva medica, 2018, Volume: 109, Issue:5 Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Factor Xa Inhibitor	2018
[Treatment of essential thrombocythemia]. Medicina clinica, 2013, Sep-21, Volume: 141, Issue:6 Topics: Adult; Age Factors; Aged; Anticoagulants; Aspirin; Cell Transformation, Neoplastic; Disease Progress	2013
Antiplatelet therapy for preventing stroke in patients with chronic kidney disease. Contributions to nephrology, 2013, Volume: 179 Topics: Aspirin; Cerebrovascular Circulation; Cohort Studies; Endothelium, Vascular; Female; Hemorrhage; Hum	2013
The risk of recurrent thromboembolic disorders in patients with unprovoked venous thromboembolism: new scenarios and opportunities. European journal of internal medicine, 2014, Volume: 25, Issue:1 Topics: Age Factors; Anticoagulants; Aspirin; Benzimidazoles; beta-Alanine; Dabigatran; Disease Management;	2014
Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. The Cochrane database of systematic reviews, 2014, Jul-04, Issue:7 Topics: Abortion, Habitual; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Enoxaparin; Female; Heparin,	2014
[Managing antithrombotic therapy in vitreoretinal surgery]. Journal francais d'ophtalmologie, 2015, Volume: 38, Issue:1 Topics: Anesthesia, Local; Anticoagulants; Aspirin; Blood Coagulation; Eye Diseases; Fibrinolytic Agents; He	2015
Antithrombotic therapy in a patient with mild haemophilia A and atrial fibrillation: case report and brief review of the literature. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2015, Volume: 26, Issue:3 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Disease Management; Dronedar	2015
Low-molecular-weight heparin plus aspirin versus aspirin alone in pregnant women with hereditary thrombophilia to improve live birth rate: meta-analysis of randomized controlled trials. Archives of gynecology and obstetrics, 2016, Volume: 293, Issue:1 Topics: Abortion, Habitual; Anticoagulants; Aspirin; Birth Weight; Female; Gestational Age; Heparin, Low-Mol	2016
Edoxaban versus placebo, aspirin, or aspirin plus clopidogrel for stroke prevention in atrial fibrillation. An indirect comparison analysis. Thrombosis and haemostasis, 2015, Volume: 114, Issue:2 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Drug	2015
Aspirin and heparin in pregnancy. Expert opinion on pharmacotherapy, 2015, Volume: 16, Issue:12 Topics: Anticoagulants; Aspirin; Female; Fibrinolytic Agents; Heparin; Humans; Pregnancy; Pregnancy Complica	2015
[Gastrointestinal bleeding]. Gastroenterologia y hepatologia, 2015, Volume: 38 Suppl 1 Topics: Anemia; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Blood Transfusion; Celecox	2015
Perioperative Management to Reduce Cardiovascular Events. Circulation, 2016, Mar-15, Volume: 133, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Anesthesia; Anticoagulants; Arthroplasty, Replacement, Knee; Aspi	2016
Stroke Prevention in Atrial Fibrillation in Patients With Chronic Kidney Disease. Circulation, 2016, Apr-12, Volume: 133, Issue:15 Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials as Topic; Creatinine; Diabetes C	2016
Anticoagulants to prevent recurrent placenta-mediated pregnancy complications: Is it time to put the needles away? Thrombosis research, 2017, Volume: 151 Suppl 1 Topics: Anticoagulants; Aspirin; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Placent	2017
[Inherited thrombophilia in women with recurrent miscarriages and pregnancy loss in anamnesis--own experience]. Ginekologia polska, 2008, Volume: 79, Issue:9 Topics: Abortion, Habitual; Adult; Aspirin; Factor V; Female; Fibrinolytic Agents; Heparin, Low-Molecular-We	2008
Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. The Cochrane database of systematic reviews, 2009, Jan-21, Issue:1 Topics: Abortion, Habitual; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecul	2009
Effect of cancer on platelets. Cancer treatment and research, 2009, Volume: 148 Topics: Animals; Aspirin; Blood Platelets; Cell Adhesion; Clinical Trials as Topic; Endothelium, Vascular; H	2009
Antiphospholipid antibody syndrome. Hematology. American Society of Hematology. Education Program, 2009 Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Aspirin; Blood Transfus	2009
ASH evidence-based guidelines: should asymptomatic patients with antiphospholipid antibodies receive primary prophylaxis to prevent thrombosis? Hematology. American Society of Hematology. Education Program, 2009 Topics: Adult; Anticoagulants; Aspirin; Double-Blind Method; Drug Therapy, Combination; Evidence-Based Medic	2009
Pathogenesis and management of essential thrombocythemia. Hematology. American Society of Hematology. Education Program, 2009 Topics: Acute Disease; Aged; Aspirin; Clone Cells; Disease Management; Disease Progression; Humans; Hydroxyu	2009
Idiopathic erythrocytosis: a disappearing entity. Hematology. American Society of Hematology. Education Program, 2009 Topics: Adult; Aspirin; Blood Viscosity; Diagnosis, Differential; Erythropoiesis; Erythropoietin; Female; He	2009
[Allergy and intolerance to nonsteroidal antinflammatory drugs: successful desensitization in three cases]. Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:2 Topics: Adult; Anaphylaxis; Angioedema; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspi	2009
Polycythemia vera. Internal and emergency medicine, 2010, Volume: 5, Issue:5 Topics: Aspirin; Disease Progression; Fibrinolytic Agents; Humans; Janus Kinase 2; Mutation; Phlebotomy; Pol	2010
JAK2 mutation and thrombosis in the myeloproliferative neoplasms. Current hematologic malignancy reports, 2010, Volume: 5, Issue:1 Topics: Amino Acid Substitution; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Fibrinolytic Ag	2010
Hemostasis in pre-eclampsia. Seminars in thrombosis and hemostasis, 2011, Volume: 37, Issue:2 Topics: Aspirin; Female; Hemostasis; Heparin, Low-Molecular-Weight; Humans; Hypertension, Pregnancy-Induced;	2011
Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections. Reumatismo, 2011, Volume: 63, Issue:1 Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Aspirin; Calcium, Dietary; Clopidogrel; Clostridioide	2011
Testing for inherited thrombophilia in recurrent miscarriage. Seminars in reproductive medicine, 2011, Volume: 29, Issue:6 Topics: Abortion, Habitual; Aspirin; Female; Heparin; Heparin, Low-Molecular-Weight; Humans; Pregnancy; Preg	2011
Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management. American journal of hematology, 2012, Volume: 87, Issue:3 Topics: Acute Disease; Age Factors; Alkylating Agents; Anticoagulants; Aspirin; Busulfan; Disease Management	2012
Recurrent miscarriage and thrombophilia: an update. Current opinion in obstetrics & gynecology, 2012, Volume: 24, Issue:4 Topics: Abortion, Habitual; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Evidence-Based Medicine; Fem	2012
Prevention of thrombosis during pregnancy. The Israel Medical Association journal : IMAJ, 2002, Volume: 4, Issue:10 Topics: Administration, Oral; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Blood Coagulation Tests; B	2002
[Anticoagulation and antiaggregation during pregnancy]. Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:1 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Abruptio Placentae; Administration, Oral; Adult;	2003
Inherited thrombophilia and gestational vascular complications. Seminars in thrombosis and hemostasis, 2003, Volume: 29, Issue:2 Topics: Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Pregnancy; Pregnancy Complications; Pregnanc	2003
Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts. Pathologie-biologie, 2003, Volume: 51, Issue:3 Topics: Aspirin; Blood Platelets; Brain Ischemia; Erythromelalgia; Hemorrhagic Disorders; Humans; Myocardial	2003
Antiphospholipid syndrome in obstetrics. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2003, Volume: 9, Issue:2 Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Annexin A5; Antibodies, Anticardiolipin; Anticoagu	2003
Quantification of risk factors for venous thromboembolism: a preliminary study for the development of a risk assessment tool. Haematologica, 2003, Volume: 88, Issue:12 Topics: Adult; Aged; Aspirin; Blood Coagulation Factors; Blood Group Antigens; Ethnicity; Gonadal Steroid Ho	2003
Thrombosis and a hypercoagulable state in HIV-infected patients. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2004, Volume: 10, Issue:3 Topics: Adult; Antibodies, Antiphospholipid; Anticoagulants; Antiretroviral Therapy, Highly Active; Aspirin;	2004
Relationship between activated clotting time and ischemic or hemorrhagic complications: analysis of 4 recent randomized clinical trials of percutaneous coronary intervention. Circulation, 2004, Aug-24, Volume: 110, Issue:8 Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Bl	2004
[Thrombophilias and vascular placental pathology. A survey of the literature]. La Revue de medecine interne, 2005, Volume: 26, Issue:2 Topics: Activated Protein C Resistance; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Cohort Studies;	2005
Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Seminars in thrombosis and hemostasis, 2005, Volume: 31, Issue:2 Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Co	2005
Metabolic syndrome. Indian journal of medical sciences, 2006, Volume: 60, Issue:2 Topics: Aspirin; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Exercise; Humans; Hydroxymethylglutaryl	2006
[Systematic lupus erythematosus and antiphospholipid syndrome during pregnancy]. Zeitschrift fur Rheumatologie, 2006, Volume: 65, Issue:3 Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Disease Progression; Female; Humans; Immunosuppr	2006
Inherited and acquired thrombophilia: pregnancy outcome and treatment. Reproductive toxicology (Elmsford, N.Y.), 2006, Volume: 22, Issue:2 Topics: Abortion, Spontaneous; Abruptio Placentae; Anticoagulants; Aspirin; Female; Fetal Growth Retardation	2006
Dyslipidaemia, hypercoagulability and the metabolic syndrome. Current vascular pharmacology, 2006, Volume: 4, Issue:3 Topics: Adipose Tissue; Adiposity; Animals; Aspirin; Cardiovascular Diseases; Cholesterol, HDL; Clofibric Ac	2006
Adverse pregnancy outcome, the uteroplacental interface, and preventive strategies. Seminars in perinatology, 2007, Volume: 31, Issue:4 Topics: Anticoagulants; Aspirin; Female; Fetal Death; Fetal Growth Retardation; Heparin; Humans; Immunoglobu	2007
[The antiphospholipid syndrome, an update]. Anales de medicina interna (Madrid, Spain : 1984), 2007, Volume: 24, Issue:5 Topics: Abortion, Spontaneous; Acenocoumarol; Adult; Antibodies, Anticardiolipin; Anticoagulants; Antiphosph	2007
Antiphospholipid syndrome in pregnancy. Hematology/oncology clinics of North America, 2008, Volume: 22, Issue:1 Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin	2008
Aspirin in essential thrombocythemia: status quo and quo vadis. Seminars in thrombosis and hemostasis, 1997, Volume: 23, Issue:4 Topics: Abortion, Habitual; Aspirin; Cerebrovascular Disorders; Cohort Studies; Contraindications; Erythrome	1997
Relation of platelet abnormalities to thrombosis and hemorrhage in chronic myeloproliferative disorders. Seminars in thrombosis and hemostasis, 1997, Volume: 23, Issue:4 Topics: Alkylating Agents; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Bone Marrow; Hematopoi	1997
Mechanism of anti-proliferative action of eicosapentaenoic acid (EPA) in vascular cell growth: its effect on signal transduction system. Advances in experimental medicine and biology, 1997, Volume: 407 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arterioscl	1997
Management of thrombosis and pregnancy loss in the antiphospholipid syndrome. Lupus, 1998, Volume: 7 Suppl 2 Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin	1998
[Antiplatelet therapy]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1999, Sep-10, Volume: 88, Issue:9 Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Arteriosclerosis; Aspirin; Clinic	1999
The pathogenesis and management of essential thrombocythaemia. Haematologica, 1999, Volume: 84 Suppl EHA-4 Topics: Acute Disease; Alkylating Agents; Aspirin; Cardiovascular Diseases; Clone Cells; Gene Expression; He	1999
Management of patients with essential thrombocythemia: current concepts and perspectives. Pathologie-biologie, 2001, Volume: 49, Issue:2 Topics: Adult; Aged; Aspirin; Case Management; Clinical Trials as Topic; Diagnosis, Differential; Disease Pr	2001

Article	Year
Aspirin, low molecular weight heparin, or both in preventing pregnancy complications in women with recurrent pregnancy loss and factor V Leiden mutation. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:11 Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Drug Administration Schedule; Drug Therapy, Comb	2020
Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study. Pharmacological research, 2020, Volume: 158 Topics: Aged; Aspirin; Betacoronavirus; Clopidogrel; Compassionate Use Trials; Coronavirus Infections; COVID	2020
Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2015, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelet Disorders; Child; Clopidogrel; F	2015
Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage. BMC research notes, 2014, Jan-09, Volume: 7 Topics: Abortion, Habitual; Adult; Aspirin; Birth Weight; Embryo Implantation; Enoxaparin; Female; Fibrinoly	2014
Comparison of Prasugrel and Ticagrelor Antiplatelet Effects in Korean Patients Presenting With ST-Segment Elevation Myocardial Infarction. Circulation journal : official journal of the Japanese Circulation Society, 2015, Volume: 79, Issue:6 Topics: Adenosine; Adult; Aged; Asian People; Aspirin; Cardiac Catheterization; Double-Blind Method; Female;	2015
Does low-molecular-weight heparin influence fetal growth or uterine and umbilical arterial Doppler in women with a history of early-onset uteroplacental insufficiency and an inheritable thrombophilia? Secondary randomised controlled trial results. BJOG : an international journal of obstetrics and gynaecology, 2016, Volume: 123, Issue:5 Topics: Adult; Anticoagulants; Aspirin; Birth Weight; Blood Flow Velocity; Drug Therapy, Combination; Female	2016
The Prevalence of Thrombophilia in Women With Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2018, Volume: 24, Issue:1 Topics: Abortion, Habitual; Adolescent; Adult; Anticoagulants; Aspirin; Enoxaparin; Female; Humans; Middle A	2018
Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. The Journal of rheumatology, 2009, Volume: 36, Issue:2 Topics: Abortion, Habitual; Adult; Antibodies, Antinuclear; Anticoagulants; Antiphospholipid Syndrome; Aspir	2009
Thrombin generation and coagulation factor activities: evaluation and comparison with the international normalized ratio. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009, Volume: 20, Issue:5 Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Blood Coagulation Factors; Blood Coagulation Tes	2009
Use of heparin in women with early and late miscarriages with and without thrombophilia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2009, Volume: 15, Issue:6 Topics: Abortion, Habitual; Adult; Age Factors; Aspirin; Biomarkers; Case-Control Studies; Dalteparin; Drug	2009
Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. Thrombosis and haemostasis, 2011, Volume: 105, Issue:2 Topics: Abortion, Habitual; Adolescent; Adult; Aspirin; Double-Blind Method; Drug Therapy, Combination; Earl	2011
Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:1 Topics: Aspirin; Drug Therapy, Combination; Female; Gestational Age; Heparin, Low-Molecular-Weight; Humans;	2012
Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr Trials, 2012, Apr-27, Volume: 13 Topics: Aspirin; Clinical Protocols; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhib	2012
Activated clotting times in the setting of eptifibatide use during percutaneous coronary intervention. Journal of thrombosis and thrombolysis, 2002, Volume: 13, Issue:3 Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Dr	2002
Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood, 2004, May-15, Volume: 103, Issue:10 Topics: Aspirin; Birth Weight; Enoxaparin; Female; Fetal Death; Folic Acid; Heparin, Low-Molecular-Weight; H	2004
Circulating procoagulant microparticles and soluble GPV in myocardial infarction treated by primary percutaneous transluminal coronary angioplasty. A possible role for GPIIb-IIIa antagonists. Journal of thrombosis and haemostasis : JTH, 2004, Volume: 2, Issue:7 Topics: Abciximab; Adrenergic beta-Antagonists; Adult; Aged; Angioplasty, Balloon, Coronary; Antibodies, Mon	2004
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3 Topics: Adult; Aged; Alanine Transaminase; Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Chronic Disea	2005
Prospective randomized comparison of early and late results of a carbonized stent versus a high-grade stainless steel stent of identical design: the PREVENT Trial [corrected]. American heart journal, 2005, Volume: 149, Issue:4 Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biocompatibl	2005
Thrombophilia and antithrombotic therapy in women with recurrent spontaneous abortions. The Journal of reproductive medicine, 2007, Volume: 52, Issue:6 Topics: Abortion, Habitual; Adult; Aspirin; Blood Coagulation Factors; Female; Fibrinolytic Agents; Greece;	2007
Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation, 2007, Sep-25, Volume: 116, Issue:13 Topics: 3' Untranslated Regions; Activated Protein C Resistance; Adult; Aspirin; Double-Blind Method; Drug A	2007
Safety and effectiveness of tinzaparin sodium in the management of recurrent pregnancy loss. Clinical and experimental obstetrics & gynecology, 2007, Volume: 34, Issue:3 Topics: Abortion, Habitual; Adult; Aspirin; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Huma	2007
Changes in levels of factor VII and protein S after acute myocardial infarction: effects of low-dose warfarin. Thrombosis research, 1999, Nov-01, Volume: 96, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antigens; Aspirin; Brain Ischemia; Death, Sudden, Ca	1999
Low-molecular-weight heparin for thrombophilia in pregnant women. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2000, Volume: 69, Issue:3 Topics: Adult; Aspirin; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weigh	2000
Management and outcome of pregnancy in women with thrombophylic disorders and past cerebrovascular events. Acta obstetricia et gynecologica Scandinavica, 2002, Volume: 81, Issue:3 Topics: Adult; Anticoagulants; Aspirin; Birth Weight; Cerebrovascular Disorders; Cohort Studies; Female; Fib	2002

Article	Year
Reproductive outcomes of women with recurrent pregnancy losses and repeated implantation failures are significantly improved with immunomodulatory treatment. Journal of reproductive immunology, 2021, Volume: 148 Topics: Abortion, Habitual; Adolescent; Adult; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Female; Fe	2021
Coagulation profiles and viscoelastic testing in multisystem inflammatory syndrome in children. Pediatric blood & cancer, 2021, Volume: 68, Issue:12 Topics: Adolescent; Anticoagulants; Aspirin; Blood Coagulation; Blood Platelets; Child; Child, Preschool; CO	2021
A young patient with recurrent myocardial infarction within a half month. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022, Jun-28, Volume: 47, Issue:6 Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Male; Myocardial Infarction; Percutaneous C	2022
Activated protein C resistance impact on Syrian candidates for in vitro fertilisation and the benefit of anticoagulation therapy: a retrospective cohort study. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2022, Volume: 42, Issue:7 Topics: Activated Protein C Resistance; Anticoagulants; Aspirin; Canada; Female; Fertilization in Vitro; Hep	2022
Uterine Radial Artery Resistance Index Predicts Reproductive Outcome in Women with Recurrent Pregnancy Losses and Thrombophilia. BioMed research international, 2019, Volume: 2019 Topics: Abortion, Habitual; Anticoagulants; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Live Bir	2019
Thrombophilia associated gene polymorphisms: Does use of medication, including anti-coagulants, minerals or folic acid, prevent the miscarriages? Journal of reproductive immunology, 2020, Volume: 141 Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Dietary Supplements; Female; Folic Acid; Humans;	2020
Analysis of the risk factors and treatment for repeated implantation failure: OPtimization of Thyroid function, IMmunity, and Uterine Milieu (OPTIMUM) treatment strategy. American journal of reproductive immunology (New York, N.Y. : 1989), 2021, Volume: 85, Issue:5 Topics: Adult; Anti-Bacterial Agents; Anticoagulants; Aspirin; Autoantibodies; Embryo Implantation; Endometr	2021
Short-Term Cessation of Dabigatran Causes a Paradoxical Prothrombotic State. Annals of neurology, 2021, Volume: 89, Issue:3 Topics: Aged; Aged, 80 and over; Animals; Antithrombins; Arachidonic Acid; Aspirin; Carotid Artery Thrombosi	2021
Antiplatelet Therapy Combined with Anastrozole Induces Features of Partial EMT in Breast Cancer Cells and Fails to Mitigate Breast-Cancer Induced Hypercoagulation. International journal of molecular sciences, 2021, Apr-16, Volume: 22, Issue:8 Topics: Adult; Anastrozole; Antineoplastic Agents, Hormonal; Aspirin; Blood Coagulation; Breast Neoplasms; C	2021
Outcomes in an obstetrical population with hereditary thrombophilia and high tobacco use. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:10 Topics: Adult; Anticoagulants; Aspirin; Case-Control Studies; Comorbidity; Female; Fetal Growth Retardation;	2018
Three cases of lymphocytic thrombophilic arteritis presenting with an annular eruption. The Australasian journal of dermatology, 2018, Volume: 59, Issue:2 Topics: Adult; Arteritis; Aspirin; Female; Fibrinolytic Agents; Humans; Lymphocytes; Middle Aged; Pentoxifyl	2018
Aspirin for thromboprophylaxis in major orthopedic surgery: old drug, new tricks? Acta bio-medica : Atenei Parmensis, 2018, 02-27, Volume: 89, Issue:1 Topics: Anticoagulants; Arthroplasty, Replacement, Knee; Aspirin; Contraindications, Drug; Drug Evaluation;	2018
Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis. Journal of perinatal medicine, 2018, Oct-25, Volume: 46, Issue:8 Topics: Adult; Aspirin; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Moscow; Pregnanc	2018
Aspirin desensitization in a woman with inherited thrombophilia and recurrent miscarriage. European annals of allergy and clinical immunology, 2012, Volume: 44, Issue:6 Topics: Abortion, Habitual; Administration, Oral; Adult; Anaphylaxis; Aspirin; Desensitization, Immunologic;	2012
Management of pregnant women with myeloproliferative neoplasms. Thrombosis research, 2013, Volume: 131 Suppl 1 Topics: Adult; Aspirin; Blood Viscosity; Female; Gestational Age; Heparin, Low-Molecular-Weight; Humans; Inc	2013
Aspirin insensitive thrombophilia: transcript profiling of blood identifies platelet abnormalities and HLA restriction. Gene, 2013, May-15, Volume: 520, Issue:2 Topics: Aspirin; Blood; Blood Platelet Disorders; Blood Platelets; Drug Resistance; Female; Gene Expression	2013
Risk Factors and Treatment Strategies in Patients With Retinal Vascular Occlusions. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2015, Volume: 21, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle	2015
[From apixaban to aspirin in the prevention of recurrent venous thromboembolism]. Investigacion clinica, 2013, Volume: 54, Issue:3 Topics: Anticoagulants; Antithrombins; Aspirin; Clinical Trials as Topic; Factor Xa Inhibitors; Heparin, Low	2013
Sticky platelet syndrome: history and future perspectives. Seminars in thrombosis and hemostasis, 2014, Volume: 40, Issue:5 Topics: Aspirin; Blood Platelet Disorders; Female; History, 20th Century; History, 21st Century; Humans; Mal	2014
Low-molecular -weight heparin in pregnancies after ART -a retrospective study-. Thrombosis research, 2014, Volume: 134, Issue:2 Topics: Adult; Anticoagulants; Aspirin; Embryo Implantation; Female; Heparin, Low-Molecular-Weight; Humans;	2014
Livedoid vasculopathy (LV) associated with sticky platelets syndrome type 3 (SPS type 3) and enhanced activity of plasminogen activator inhibitor (PAI-1) anomalies. International journal of dermatology, 2014, Volume: 53, Issue:12 Topics: Aspirin; Blood Platelets; Child; Female; Humans; Leg Ulcer; Plasminogen Activator Inhibitor 1; Plate	2014
Effects of anticoagulant therapy on pregnancy outcomes in patients with thrombophilia and previous poor obstetric history. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2015, Volume: 26, Issue:3 Topics: Abortion, Habitual; Anticoagulants; Apgar Score; Aspirin; Birth Weight; Blood Coagulation Factors; D	2015
[Hypercoagulation syndrome in multiple myeloma]. Terapevticheskii arkhiv, 2014, Volume: 86, Issue:7 Topics: Adult; Aged; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Drug Administr	2014
Effect of anticoagulant therapy on cell-derived microparticles and pregnancy outcome in women with pregnancy loss. British journal of haematology, 2015, Volume: 171, Issue:5 Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Case-Control Studies; Cell-Derived Microparticle	2015
The role of coagulation disorders in patients with retinal vein occlusion. QJM : monthly journal of the Association of Physicians, 2016, Volume: 109, Issue:2 Topics: Aged; Antibodies, Antiphospholipid; Anticoagulants; Aspirin; Case-Control Studies; Female; Homocyste	2016
Impact of bridging with perioperative low-molecular-weight heparin on cardiac and bleeding outcomes of stented patients undergoing non-cardiac surgery. Thrombosis and haemostasis, 2015, Volume: 114, Issue:2 Topics: Acute Coronary Syndrome; Aged; Aspirin; Comorbidity; Coronary Disease; Coronary Restenosis; Drug Sub	2015
Clopidogrel response variability is associated with endothelial dysfunction in coronary artery disease patients receiving dual antiplatelet therapy. Atherosclerosis, 2015, Volume: 242, Issue:1 Topics: Activation, Metabolic; Aged; Aspirin; Brachial Artery; Clopidogrel; Coronary Disease; Cytochrome P-4	2015
[INDICATIONS FOR ANTITHROMBOTIC MEDICATION DURING PREGNANCY--ANALYSIS OF CURRENT PRACTICES IN BULGARIA]. Akusherstvo i ginekologiia, 2015, Volume: 54, Issue:5 Topics: Anticoagulants; Antiphospholipid Syndrome; Aspirin; Bulgaria; Female; Heparin; Heparin, Low-Molecula	2015
Microparticles and blood cells induce procoagulant activity via phosphatidylserine exposure in NSTEMI patients following stent implantation. International journal of cardiology, 2016, Nov-15, Volume: 223 Topics: Aged; Aspirin; Blood Cells; Blood Coagulation; Cell-Derived Microparticles; Clopidogrel; Female; Hum	2016
Pregnancy in β-thalassemia intermedia at two tertiary care centers in Lebanon and Italy: A follow-up report on fetal and maternal outcomes. American journal of hematology, 2017, Volume: 92, Issue:6 Topics: Abortion, Habitual; Abortion, Spontaneous; Aspirin; beta-Thalassemia; Birth Weight; Cesarean Section	2017
Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest, 2008, Volume: 133, Issue:6 Suppl Topics: Antibodies, Antiphospholipid; Antithrombin III Deficiency; Aspirin; Evidence-Based Medicine; Female;	2008
Patient with hypofibrinolysis-mediated thromboembolism converted to a hypercoagulable/hyperfibrinolytic state via ventricular assist device placement. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2008, Volume: 27, Issue:10 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Echocardiography, Transesophageal; Female; Fibrinolysi	2008
Ask the doctor. In October 2007, I had three Cypher stents placed in my left anterior descending artery. My doctor told me to take Plavix and aspirin indefinitely. Now I need to have a hernia repaired. My surgeon refuses to operate while I'm taking Plavix Harvard heart letter : from Harvard Medical School, 2008, Volume: 18, Issue:12 Topics: Aspirin; Clopidogrel; Contraindications; Platelet Aggregation Inhibitors; Stents; Thoracic Surgery;	2008
Paget-Schroetter syndrome forerunning the diagnoses of thoracic outlet syndrome and thrombophilia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2010, Volume: 16, Issue:3 Topics: Activated Protein C Resistance; Anticoagulants; Aspirin; Enoxaparin; Factor V; Heterozygote; Humans;	2010
[Intradural block in essential thrombocytosis]. Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:1 Topics: Aged, 80 and over; Anesthesia, Spinal; Aspirin; Female; Fracture Fixation, Internal; Hematoma, Epidu	2009
Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke? Journal of the neurological sciences, 2009, Sep-15, Volume: 284, Issue:1-2 Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinol	2009
Does anticoagulation benefit patients with congestive heart failure (CHF) who have reduced left ventricular ejection fraction (LVEF) and are in normal sinus rhythm? The Journal of the Oklahoma State Medical Association, 2009, Volume: 102, Issue:4 Topics: Anticoagulants; Aspirin; Evidence-Based Medicine; Female; Heart Failure; Humans; Male; Meta-Analysis	2009
The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009, Volume: 20, Issue:6 Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Comorbidity; Drug Resistance; Electrocardi	2009
[Recurrent spontaneous abortion--is heparin expendable to recurrence prophylaxis?]. Zeitschrift fur Rheumatologie, 2009, Volume: 68, Issue:6 Topics: Abortion, Habitual; Adult; Antibodies, Antinuclear; Anticoagulants; Antiphospholipid Syndrome; Aspir	2009
New observations in postpartum ovarian vein thrombosis: experience of single center. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:1 Topics: Adult; Anticoagulants; Aspirin; Cesarean Section; Early Diagnosis; Enoxaparin; Female; Humans; Incid	2010
JAK2V617F mutation-positive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis. Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:9 Topics: Aspirin; Child; Clone Cells; Cytotoxins; Diagnosis, Differential; Female; Headache; Humans; Hydroxyu	2009
Thrombophilic factors do not predict outcomes in renal transplant recipients under prophylactic acetylsalicylic acid. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2010, Volume: 10, Issue:1 Topics: Acute Disease; Adult; Aspirin; Cardiovascular Diseases; Cohort Studies; Creatinine; Female; Fibrinol	2010
Pro: "Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation". Thrombosis and haemostasis, 2009, Volume: 102, Issue:5 Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials as Topic;	2009
Contra: "Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation". Thrombosis and haemostasis, 2009, Volume: 102, Issue:5 Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clinica	2009
Impact of genetic polymorphisms on platelet function and aspirin resistance. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:1 Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Proteins; Collagen; Drug Resistance; Epinephrine; Female	2010
Positional brain ischemia with MCA occlusion successfully treated with extra-intracranial bypass. Cerebrovascular diseases (Basel, Switzerland), 2010, Volume: 29, Issue:4 Topics: Aspirin; Cerebral Revascularization; Clopidogrel; Humans; Infarction, Middle Cerebral Artery; Ischem	2010
Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2011, Volume: 22, Issue:1 Topics: Adult; Anticoagulants; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Pregnancy; Pregnancy	2011
Clinical and angiographic outcomes with sirolimus-eluting stent for coronary bifurcation lesions. The J-PMS study. Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:2 Topics: Angioplasty; Aspirin; Calcinosis; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coro	2011
LMWH have no place in recurrent pregnancy loss: debate-against the motion. Thrombosis research, 2011, Volume: 127 Suppl 3 Topics: Abortion, Habitual; Anticoagulants; Aspirin; Embryo Loss; Female; Fetus; Heparin, Low-Molecular-Weig	2011
Some considerations about the hypercoagulable states and their treatments. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2011, Volume: 22, Issue:3 Topics: Anticoagulants; Aspirin; Heparin; Humans; Platelet Aggregation Inhibitors; Thrombophilia; Warfarin	2011
Fabry disease and Factor V Leiden: a potent vascular risk combination. Internal medicine journal, 2011, Volume: 41, Issue:5 Topics: Activated Protein C Resistance; alpha-Galactosidase; Aspirin; Atorvastatin; Coronary Stenosis; Defib	2011
Anticoagulant-resistant thrombophilia in a patient with polycythemia vera: a case report. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2011, Volume: 22, Issue:8 Topics: Aged; Anticoagulants; Aspirin; Factor Xa; Factor Xa Inhibitors; Fatal Outcome; Heparin, Low-Molecula	2011
Thrombus formation on a left atrial appendage closure device. Circulation, 2011, Oct-04, Volume: 124, Issue:14 Topics: Aged; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Equipment Design;	2011
[Our experience with management of inherited thrombophilia during pregnancy. Preliminary report]. Akusherstvo i ginekologiia, 2011, Volume: 50, Issue:6 Topics: Aspirin; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Pregnancy; Pregnancy Co	2011
Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT: a rebuttal. Journal of thrombosis and haemostasis : JTH, 2012, Volume: 10, Issue:6 Topics: Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Pre-Eclampsia; Pregnancy; Thrombophilia	2012
[Our experience with management of inherited thrombophilia during pregnancy: preliminary report]. Akusherstvo i ginekologiia, 2011, Volume: 50 Suppl 2 Topics: Aspirin; Factor V; Female; Fibrinolytic Agents; Genetic Testing; Heparin, Low-Molecular-Weight; Huma	2011
Recurrent pediatric thrombosis: the effect of underlying and/or coexisting factors. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2012, Volume: 23, Issue:5 Topics: Adolescent; Adult; Anticoagulants; Aspirin; Child; Child, Preschool; Chronic Disease; Factor VIII; F	2012
Long-term risk of vascular events after peripheral bypass surgery. A cohort study. Thrombosis and haemostasis, 2012, Volume: 108, Issue:3 Topics: Administration, Oral; Aged; Aged, 80 and over; Amputation, Surgical; Anticoagulants; Aspirin; Blood	2012
Anticoagulant therapy during pregnancy for maternal and fetal acquired and inherited thrombophilia. Current medicinal chemistry, 2012, Volume: 19, Issue:27 Topics: Anticoagulants; Aspirin; Bone Density; Breast Feeding; Chondroitin Sulfates; Dermatan Sulfate; Femal	2012
Successful treatment of cerebral venous sinus thrombosis with the Solitaire FR thrombectomy device. Journal of neurointerventional surgery, 2013, Volume: 5, Issue:6 Topics: Anticoagulants; Aspirin; Cerebral Angiography; Endovascular Procedures; Female; Follow-Up Studies; H	2013
Preventing adverse obstetric outcomes in women with genetic thrombophilia. Fertility and sterility, 2002, Volume: 78, Issue:2 Topics: Aspirin; Enoxaparin; Female; Fibrinolytic Agents; Heparin; Humans; Pregnancy; Pregnancy Complication	2002
Recurrent thromboembolism in a patient with beta-thalassemia major associated with double heterozygosity for factor V R506Q and prothrombin G20210A mutations. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2002, Volume: 13, Issue:5 Topics: 3' Untranslated Regions; Activated Protein C Resistance; Adult; Anticoagulants; Aspirin; beta-Thalas	2002
Management of thrombosis during pregnancy. The Israel Medical Association journal : IMAJ, 2002, Volume: 4, Issue:10 Topics: Anticoagulants; Antiphospholipid Syndrome; Antithrombins; Aspirin; Blood Coagulation Tests; Drug The	2002
Management of thrombophilia in renal transplant patients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2002, Volume: 2, Issue:9 Topics: Anticoagulants; Aspirin; Graft Rejection; Humans; Kidney Transplantation; Platelet Aggregation Inhib	2002
Evaluation of the marker of hypercoagulability prothrombin fragment F 1+2 in patients with mechanical or biological heart valve prostheses. Arquivos brasileiros de cardiologia, 2002, Volume: 79, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Aged; Anticoagulants; Aspirin; Biomarkers; Bioprosthesis; F	2002
Thrombophilic causes of retinal vascular thrombosis: etiology and treatment outcomes. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2002, Volume: 8, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Da	2002
Going with the flow of anticoagulant therapy. Nursing, 2003, Volume: 33, Issue:3 Topics: Anticoagulants; Aspirin; Dipyridamole; Heparin; Humans; Patient Education as Topic; Platelet Aggrega	2003
Bilateral superior ophthalmic vein thrombosis in a young woman. Acta ophthalmologica Scandinavica, 2003, Volume: 81, Issue:1 Topics: Adult; Aspirin; Eye; Factor VIII; Female; Fibrinolytic Agents; Humans; Risk Factors; Thrombophilia;	2003
Thromboprophylaxis throughout pregnancy in women with previous history of recurrent miscarriages of unknown aetiology. Clinical and experimental obstetrics & gynecology, 2002, Volume: 29, Issue:4 Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Cohort Studies; Drug Administration Schedule; Fe	2002
Anti-beta2-glycoprotein I antibodies and ischemic stroke in a 20-month-old boy. Pediatrics, 2003, Volume: 112, Issue:1 Pt 1 Topics: Antibodies, Anticardiolipin; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoantibodies; Bas	2003
Recurrent transient ischemic attacks in a 15-year-old boy with beta-thalassemia minor and thrombophilia. Contribution of perfusion SPECT to clinical diagnosis. Acta neurologica Belgica, 2003, Volume: 103, Issue:2 Topics: Adolescent; Anticoagulants; Aspirin; beta-Thalassemia; Brain; Factor V; Female; Heterozygote; Humans	2003
[Successful pregnancy outcome in the woman with thrombophilia and multiple miscarriages]. Ginekologia polska, 2003, Volume: 74, Issue:5 Topics: Abortion, Habitual; Adult; Anticoagulants; Aspirin; Cesarean Section; Factor V; Female; Heterozygote	2003
Evans syndrome associated with antiphospholipid antibodies. Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:9 Topics: Adolescent; Anemia, Hemolytic, Autoimmune; Antibodies, Antinuclear; Antibodies, Antiphospholipid; An	2003
Pregnancy outcome in patients with a history of recurrent spontaneous miscarriages and documented thrombophilias. Gynecologic and obstetric investigation, 2004, Volume: 57, Issue:3 Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Female; Folic Acid; Heparin, Low-M	2004
[New antiplatelet agents (platelet receptor blockers): has aspirin come out of place?]. Praxis, 2004, Jun-02, Volume: 93, Issue:23 Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Huma	2004
Effects of low-molecular-weight and unfractionated heparin on trophoblast function. Obstetrics and gynecology, 2004, Volume: 104, Issue:2 Topics: Anticoagulants; Aspirin; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Female; Heparin	2004
Antiphospholipid syndrome in a child: an insight into the pathology, identification, and means of cure. Journal of pediatric surgery, 2004, Volume: 39, Issue:8 Topics: Antibodies, Anticardiolipin; Anticoagulants; Antiphospholipid Syndrome; Arterial Occlusive Diseases;	2004
Prescribing for thrombophilia--are we going to repeat mistakes of the past? Gynecologic and obstetric investigation, 2004, Volume: 58, Issue:4 Topics: Abortion, Habitual; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin	2004
Selective inhibition of cyclooxygenase-2 enhances platelet adhesion in hamster arterioles in vivo. Circulation, 2004, Oct-05, Volume: 110, Issue:14 Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Arterioles; Aspirin; Cells, Cultured;	2004
Predictors of cognitive dysfunction in patients with systemic lupus erythematosus. Neurology, 2005, Jan-25, Volume: 64, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Aspirin; Autoant	2005
Hypercoagulability affecting early vein graft patency does not exist after off-pump coronary artery bypass. Journal of cardiothoracic and vascular anesthesia, 2005, Volume: 19, Issue:1 Topics: Aged; Aged, 80 and over; Aspirin; Coronary Artery Bypass, Off-Pump; Female; Graft Occlusion, Vascula	2005
Dual antiplatelet therapy for coronary stenting: a clear path for a research agenda. Circulation, 2005, Mar-08, Volume: 111, Issue:9 Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug A	2005
The role of platelet glycoprotein IIIa polymorphism in the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis. American heart journal, 2005, Volume: 149, Issue:4 Topics: Aged; Alleles; Antigens, Human Platelet; Aspirin; Coronary Restenosis; Coronary Stenosis; DNA Mutati	2005
Stroke following Glenn anastomosis in a child with inherited thrombophilia. International journal of cardiology, 2006, Aug-28, Volume: 111, Issue:3 Topics: Anastomosis, Surgical; Aspirin; Brain Ischemia; Child, Preschool; Fibrinolytic Agents; Heart Bypass,	2006
Thrombophilia and severe preeclampsia: time to screen and treat in future pregnancies? Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:6 Topics: Anticoagulants; Aspirin; Dose-Response Relationship, Drug; Female; Heparin; Humans; Mass Screening;	2005
[Recurrent miscarriage and thrombophilia]. Nederlands tijdschrift voor geneeskunde, 2006, Mar-04, Volume: 150, Issue:9 Topics: Abortion, Habitual; Adult; Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecular-Weight	2006
The natural course of women with recurrent fetal loss. Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:4 Topics: Abortion, Habitual; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Enoxaparin; Female; Fibrinolyt	2006
Aspirin for prevention of stroke in atrial fibrillation. Stroke, 2006, Volume: 37, Issue:7 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Humans; Platelet Aggregation Inhibitors; Stroke; Throm	2006
Enhanced platelet activation by prolactin in patients with ischemic stroke. Thrombosis and haemostasis, 2006, Volume: 96, Issue:1 Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Female; Humans; Ischemic Attack, Tran	2006
Impact of PlA polymorphism of platelet GP IIb/IIIa receptors on clinical course during long-term LVAD support is independent of type of LVAD. The Annals of thoracic surgery, 2006, Volume: 82, Issue:3 Topics: Anticoagulants; Antigens, Human Platelet; Aspirin; Clopidogrel; Equipment Design; Genetic Predisposi	2006
Platelet-mediated erythromelalgic, cerebral, ocular and coronary microvascular ischemic and thrombotic manifestations in patients with essential thrombocythemia and polycythemia vera: a distinct aspirin-responsive and coumadin-resistant arterial thromboph Platelets, 2006, Volume: 17, Issue:8 Topics: Aged; Anticoagulants; Aspirin; Drug Resistance; Erythromelalgia; Female; Humans; Ischemia; Male; Mic	2006
Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation, 2007, May-15, Volume: 115, Issue:19 Topics: Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Black or African American; Blood Platelets;	2007
Heritability, platelet function, and aspirin: a link established but cause unknown. Circulation, 2007, May-15, Volume: 115, Issue:19 Topics: Arachidonic Acid; Aspirin; Black or African American; Blood Platelets; Cardiovascular Diseases; Cycl	2007
Management of thrombophiliac problems during pregnancy. Irish medical journal, 2007, Volume: 100, Issue:6 Topics: Adult; Antiphospholipid Syndrome; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Pregnancy;	2007
Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2007, Volume: 29, Issue:10 Topics: Abruptio Placentae; Adult; Anticoagulants; Aspirin; Dalteparin; Drug Therapy, Combination; Female; F	2007
Sticky platelet syndrome and anterior ischaemic optic neuropathy. Clinical & experimental ophthalmology, 2007, Volume: 35, Issue:8 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelet Disorders; Humans; Male	2007
Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary. Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:4 Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Algorithms; Arachidonic Acid; Aspirin; Calibr	2008
Prevention of thrombosis in polycythemia vera and essential thrombocythemia. Haematologica, 2008, Volume: 93, Issue:3 Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans;	2008
Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition? Pathophysiology of haemostasis and thrombosis, 2007, Volume: 36, Issue:1 Topics: Animals; Aspirin; Bleeding Time; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cy	2007
[Stents, antiplatelet therapy, and surgery]. Revista espanola de anestesiologia y reanimacion, 2008, Volume: 55, Issue:3 Topics: Adult; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cesarean Section; Enoxaparin; Female	2008
The paradox of bleeding and thrombosis in thrombocythemia: is von Willebrand factor the link? Seminars in thrombosis and hemostasis, 1997, Volume: 23, Issue:4 Topics: Aged; Alkylating Agents; Aspirin; Erythromelalgia; Female; Fibrinolytic Agents; Hemorrhage; Hemorrha	1997
Low-molecular-weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study. European journal of obstetrics, gynecology, and reproductive biology, 1998, Volume: 80, Issue:1 Topics: Aspirin; Drug Therapy, Combination; Female; Fetal Growth Retardation; Gestational Age; Heparin, Low-	1998
Craniofacial pain followed by scalp necrosis and stroke. An unusual presentation of the primary antiphospholipid syndrome. Journal of neurology, 1999, Volume: 246, Issue:2 Topics: Aged; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune D	1999
Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin. Thrombosis and haemostasis, 2000, Volume: 83, Issue:5 Topics: 3' Untranslated Regions; Abortion, Habitual; Activated Protein C Resistance; Adult; Anticoagulants;	2000
100 mg acetylsalicylic acid acutely decreases red cell aggregation in women taking oral contraceptives. Clinical hemorheology and microcirculation, 2000, Volume: 22, Issue:2 Topics: Adult; Aspirin; Blood Viscosity; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Cyp	2000
Thromboembolic neurologic events in patients with antiphospholipid-antibody syndrome. Italian journal of neurological sciences, 1999, Volume: 20, Issue:1 Topics: Administration, Oral; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune Diseases; Hemor	1999
[Aspects of thrombophilia in Buerger's disease]. Recenti progressi in medicina, 2000, Volume: 91, Issue:9 Topics: Adjuvants, Immunologic; Adult; Angiography; Aspirin; Female; Humans; Hyperhomocysteinemia; Iloprost;	2000
Effect of thrombophylaxis on uterine and fetal circulation in pregnant women with a history of pregnancy complications. Thrombosis research, 2001, Feb-15, Volume: 101, Issue:4 Topics: Abortion, Habitual; Aspirin; Female; Fetal Growth Retardation; Fetus; Heparin, Low-Molecular-Weight;	2001
Non-pregnant circulatory volume status predicts subsequent pregnancy outcome in normotensive thrombophilic formerly preeclamptic women. European journal of obstetrics, gynecology, and reproductive biology, 2001, Volume: 95, Issue:2 Topics: Aspirin; Birth Weight; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; HELLP Syndrome	2001
Individual dosing of ASA prophylaxis by controlling platelet aggregation. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2001, Volume: 7, Issue:3 Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Diabetes Mellitus, Type 2; Dose-Response Relatio	2001
Patients' thromboembolic potential between bilateral carotid endarterectomies remains stable over time. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2001, Volume: 22, Issue:6 Topics: Aspirin; Endarterectomy, Carotid; Female; Fibrinolytic Agents; Humans; Intracranial Embolism and Thr	2001

aspirin and Hypercoagulability