aspirin has been researched along with Hemorrhagic Shock in 60 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the infusion of up to 1000 mL of diaspirin cross-linked hemoglobin (DCLHb) during the initial hospital resuscitation could reduce 28-day mortality in traumatic hemorrhagic shock patients." | 9.09 | Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. ( Cipolle, M; Gens, D; Koenigsberg, M; Mallory, MN; Rodman, G; Runge, J; Sloan, EP, 1999) |
| "In the clinical trial of diaspirin cross-linked hemoglobin (DCLHb), optimal therapy required the immediate enrollment of patients with severe, uncompensated, traumatic hemorrhagic shock." | 9.09 | The informed consent process and the use of the exception to informed consent in the clinical trial of diaspirin cross-linked hemoglobin (DCLHb) in severe traumatic hemorrhagic shock. DCLHb Traumatic Hemorrhagic Shock study group. ( Cipolle, M; Gens, D; Houghton, J; Koenigsberg, M; Mallory, MN; Rodman, G; Runge, J; Sloan, EP, 1999) |
| "Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities." | 7.76 | Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010) |
| "The hemoglobin based oxygen carrier (HBOC) Diaspirin Crosslinked Hemoglobin (DCLHb) has been developed to substitute not only the blood volume, but also to restore the oxygen-carrying properties of blood during hemorrhagic shock." | 7.73 | Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on microcirculation and local tissue pO2 of striated skin muscle following resuscitation from hemorrhagic shock. ( Botzlar, A; Hungerer, S; Messmer, K; Nolte, D, 2006) |
| " This large, multicenter, randomized clinical trial was designed to compare the addition of diaspirin cross-linked hemoglobin (DCLHb) with standard care in the initial resuscitation of adults experiencing severe, uncompensated, traumatic hemorrhagic shock." | 7.71 | Monitoring a clinical trial conducted under the Food and Drug Administration regulations allowing a waiver of prospective informed consent: the diaspirin cross-linked hemoglobin traumatic hemorrhagic shock efficacy trial. ( Bechhofer, R; Berry, DA; Blue, JW; Cook, T; Cryer, H; Fisher, M; Fost, N; Houghton, J; Krome, R; Lewis, RJ; Washington, GR, 2001) |
| "The efficacy trial of diaspirin cross-linked hemoglobin (DCLHb) in traumatic hemorrhagic shock demonstrated an unexpected mortality imbalance, prompting a three-step review to better understand the cause of this finding." | 7.71 | Post hoc mortality analysis of the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shock. ( Brunett, PH; Bynoe, RP; Dalsey, WC; Koenigsberg, M; Morris, JA; Ochsner, MG; Sloan, EP; Tinkoff, G, 2002) |
| "To evaluate the effects of resuscitation with a 10% diaspirin-crosslinked hemoglobin (DCLHb) solution on global hemodynamic variables, systemic and myocardial oxygen transport and tissue oxygenation, and contractile function of the left ventricle in an experimental model of severe hemorrhagic shock and critical stenosis of the left anterior descending coronary artery (LAD)." | 7.70 | Diaspirin-crosslinked hemoglobin reduces mortality of severe hemorrhagic shock in pigs with critical coronary stenosis. ( Habler, O; Kemming, G; Kleen, M; Meisner, F; Messmer, K; Pape, A, 2000) |
| "The efficacy of Diaspirin Crosslinked Hemoglobin (DCLHb) as a resuscitative fluid in hemorrhagic shock was compared to another colloid solution (human serum albumin, HSA) and a crystalloid solution (Lactated Ringer's, LR)." | 7.69 | Resuscitation with Diaspirin Crosslinked Hemoglobin in a pig model of hemorrhagic shock. ( Burhop, K; Dunlap, E; Estep, T; Farrell, L; Marchand, G; Nigro, C, 1995) |
| "The effects of hemorrhagic shock, aspirin, and ethanol on the biochemical and morphologic changes of experimental pancreatitis were evaluated." | 7.68 | Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis. ( Leli, U; Printz, H; Saluja, A; Sengupta, A; Steer, M, 1990) |
| "Fluid resuscitation from hemorrhagic shock is intended to abolish microcirculatory disorders and to restore adequate tissue oxygenation." | 5.32 | Fluid resuscitation from severe hemorrhagic shock using diaspirin cross-linked hemoglobin fails to improve pancreatic and renal perfusion. ( Habler, O; Kemming, G; Kleen, M; Meier, J; Meisner, F; Pape, A, 2004) |
| "The combination of hemorrhagic shock, aspirin, and acid caused pronounced mucosal lesions, whereas only minor lesions were seen with aspirin and acid alone." | 5.27 | Canine gastric ulcer produced by hemorrhagic shock and aspirin. ( Amdrup, E; Casalnuovo, CA; Kraglund, K; Kristensen, IB, 1984) |
| "To determine if the infusion of up to 1000 mL of diaspirin cross-linked hemoglobin (DCLHb) during the initial hospital resuscitation could reduce 28-day mortality in traumatic hemorrhagic shock patients." | 5.09 | Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. ( Cipolle, M; Gens, D; Koenigsberg, M; Mallory, MN; Rodman, G; Runge, J; Sloan, EP, 1999) |
| "In the clinical trial of diaspirin cross-linked hemoglobin (DCLHb), optimal therapy required the immediate enrollment of patients with severe, uncompensated, traumatic hemorrhagic shock." | 5.09 | The informed consent process and the use of the exception to informed consent in the clinical trial of diaspirin cross-linked hemoglobin (DCLHb) in severe traumatic hemorrhagic shock. DCLHb Traumatic Hemorrhagic Shock study group. ( Cipolle, M; Gens, D; Houghton, J; Koenigsberg, M; Mallory, MN; Rodman, G; Runge, J; Sloan, EP, 1999) |
| " A multicenter, randomized, single-blinded, normal saline procedure-controlled efficacy trial of diaspirin cross-linked hemoglobin (DCLHb) in acute traumatic hemorrhagic shock was conducted." | 4.80 | A proposed consent process in studies that use an exception to informed consent. ( Barrett, J; Nagy, K; Sloan, EP, 1999) |
| "To assess the ability of the shock index (SI) to predict 28-day mortality in traumatic hemorrhagic shock patients treated in the diaspirin cross-linked hemoglobin (DCLHb) resuscitation clinical trials." | 3.80 | Shock index and prediction of traumatic hemorrhagic shock 28-day mortality: data from the DCLHb resuscitation clinical trials. ( Clark, JM; Koenigsberg, M; Philbin, N; Sloan, EP; Weir, WB, 2014) |
| "Diaspirin cross-linked hemoglobin (DCLHb) has demonstrated a pressor effect that could adversely affect traumatic hemorrhagic shock patients through diminished perfusion to vital organs, causing base deficit (BD) and lactate abnormalities." | 3.76 | Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. ( Gao, W; Koenigsberg, MD; Philbin, NB; Sloan, EP, 2010) |
| ", diaspirin-cross-linked hemoglobin [DCLHb] and hemoglobin glutamer-200 [HbG]) may have potential in the treatment of hemorrhagic shock." | 3.73 | Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock. ( Bauer, I; Bauer, M; Kubulus, D; Meisel, T; Paxian, M; Redl, H; Rensing, H; Thierbach, JT, 2005) |
| " This large, multicenter, randomized clinical trial was designed to compare the addition of diaspirin cross-linked hemoglobin (DCLHb) with standard care in the initial resuscitation of adults experiencing severe, uncompensated, traumatic hemorrhagic shock." | 3.71 | Monitoring a clinical trial conducted under the Food and Drug Administration regulations allowing a waiver of prospective informed consent: the diaspirin cross-linked hemoglobin traumatic hemorrhagic shock efficacy trial. ( Bechhofer, R; Berry, DA; Blue, JW; Cook, T; Cryer, H; Fisher, M; Fost, N; Houghton, J; Krome, R; Lewis, RJ; Washington, GR, 2001) |
| "The efficacy trial of diaspirin cross-linked hemoglobin (DCLHb) in traumatic hemorrhagic shock demonstrated an unexpected mortality imbalance, prompting a three-step review to better understand the cause of this finding." | 3.71 | Post hoc mortality analysis of the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shock. ( Brunett, PH; Bynoe, RP; Dalsey, WC; Koenigsberg, M; Morris, JA; Ochsner, MG; Sloan, EP; Tinkoff, G, 2002) |
| "Anesthetized swine were randomized to receive SPR, diaspirin cross-linked hemoglobin, or DR after cryogenic brain injury and uncontrolled hemorrhagic shock and studied for 70 minutes after the combined insults." | 3.70 | Comparison of standard and alternative prehospital resuscitation in uncontrolled hemorrhagic shock and head injury. ( Bourguignon, P; Buckingham, S; Nichols, P; Novak, L; Osler, T; Sartorelli, K; Shackford, SR, 1999) |
| "To evaluate the effects of resuscitation with a 10% diaspirin-crosslinked hemoglobin (DCLHb) solution on global hemodynamic variables, systemic and myocardial oxygen transport and tissue oxygenation, and contractile function of the left ventricle in an experimental model of severe hemorrhagic shock and critical stenosis of the left anterior descending coronary artery (LAD)." | 3.70 | Diaspirin-crosslinked hemoglobin reduces mortality of severe hemorrhagic shock in pigs with critical coronary stenosis. ( Habler, O; Kemming, G; Kleen, M; Meisner, F; Messmer, K; Pape, A, 2000) |
| "The efficacy of Diaspirin Crosslinked Hemoglobin (DCLHb) as a resuscitative fluid in hemorrhagic shock was compared to another colloid solution (human serum albumin, HSA) and a crystalloid solution (Lactated Ringer's, LR)." | 3.69 | Resuscitation with Diaspirin Crosslinked Hemoglobin in a pig model of hemorrhagic shock. ( Burhop, K; Dunlap, E; Estep, T; Farrell, L; Marchand, G; Nigro, C, 1995) |
| "5, 4, 10, and 30 mL/kg of Diaspirin Crosslinked Hemoglobin (DCLHb) in a swine model of non-lethal hemorrhagic shock." | 3.69 | Resuscitation with increasing doses of diaspirin crosslinked hemoglobin in swine. ( Burhop, K; Dunlap, E; Farrell, L; Marchand, G; Nigro, C, 1996) |
| "The effects of hemorrhagic shock, aspirin, and ethanol on the biochemical and morphologic changes of experimental pancreatitis were evaluated." | 3.68 | Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis. ( Leli, U; Printz, H; Saluja, A; Sengupta, A; Steer, M, 1990) |
| "Spontaneous splenic rupture is a rare but potentially fatal complication." | 2.48 | Spontaneous splenic rupture in infectious mononucleosis: case report and review of the literature. ( Pomerantz, WJ; Rinderknecht, AS, 2012) |
| "A controlled hemorrhagic shock (blood withdrawal of 40 mL/kg) was followed by resuscitation with either a combination of lactated Ringer's solution (75 mL/kg) and modified gelatin (15 mL/kg)(lactR/Gel) or 10% DCLHb (5 mL/kg)." | 1.30 | Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine. ( Burhop, K; Ince, C; Sinaasappel, M; Trouwborst, A; van Iterson, M, 1998) |
| "Resuscitation from severe hemorrhagic shock (bleeding of 33 ml x kg(-1) at 0." | 1.30 | Effects of diaspirin-cross-linked hemoglobin (DCLHb) on local tissue oxygen tension in striated skin muscle: an efficacy study in the hamster. ( Berger, S; Härtl, R; Messmer, K; Nolte, D; Pickelmann, S; Steinhauser, P, 1997) |
| "The gastric damage associated with hemorrhagic shock appears to occur, at least in part, through neutrophil-dependent mechanisms." | 1.30 | Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils. ( Cirino, G; Del Soldato, P; McKnight, W; Wallace, JL; Wilson, TL, 1997) |
| "Severe hemorrhagic shock was induced by a 25-gauge needle puncture to the infrarenal aorta." | 1.29 | Early resuscitation with low-volume PolyDCLHb is effective in the treatment of shock induced by penetrating vascular injury. ( Burris, D; Hufnagel, H; Leppäniemi, A; Malcolm, D; Pikoulis, E; Ratigan, J; Soltero, R; Waasdorp, C, 1996) |
| "We developed a rat model of hemorrhagic shock based on achieving a fixed BD of 13 +/- 1 mmol/L before resuscitation." | 1.29 | Use of base deficit to compare resuscitation with lactated Ringer's solution, Haemaccel, whole blood, and diaspirin cross-linked hemoglobin following hemorrhage in rats. ( Hamilton, IN; Malcolm, DS; Schultz, SC, 1993) |
| "The combination of hemorrhagic shock, aspirin, and acid caused pronounced mucosal lesions, whereas only minor lesions were seen with aspirin and acid alone." | 1.27 | Canine gastric ulcer produced by hemorrhagic shock and aspirin. ( Amdrup, E; Casalnuovo, CA; Kraglund, K; Kristensen, IB, 1984) |
| "When hemorrhagic shock was induced during acid perfusion, a profound acidification of the subepithelial tissue occurred even though a much lower luminal acidity (10 mM HCl) was used." | 1.27 | Subepithelial tissue pH of rat gastric mucosa exposed to luminal acid, barrier breaking agents, and hemorrhagic shock. ( Kivilaakso, E; Kiviluoto, T; Voipio, J, 1988) |
| "Aspirin tablets were placed in the stomach of anesthetized cats by gastrotomy." | 1.26 | Aspirin damage to ischemic gastric mucosa in shocked cats. ( Leiknes, KA; Svanes, K; Søreide, O; Varhaug, JE, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (26.67) | 18.7374 |
| 1990's | 19 (31.67) | 18.2507 |
| 2000's | 17 (28.33) | 29.6817 |
| 2010's | 8 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aubert, J | 1 |
| Delalande, JP | 1 |
| Skowronski, P | 1 |
| Yamada, S | 1 |
| Yotsueda, H | 1 |
| Nagara, T | 1 |
| Goto, K | 1 |
| Nakashima, Y | 1 |
| Hirakata, H | 1 |
| Fujimi, S | 1 |
| Tsuruya, K | 1 |
| Sloan, EP | 11 |
| Koenigsberg, M | 6 |
| Clark, JM | 3 |
| Weir, WB | 2 |
| Philbin, N | 1 |
| O'Connor, R | 1 |
| Olinger, M | 1 |
| Cydulka, R | 1 |
| Philbin, NB | 2 |
| Koenigsberg, MD | 2 |
| Gao, W | 2 |
| Desai, A | 1 |
| Rinderknecht, AS | 1 |
| Pomerantz, WJ | 1 |
| Ward, CG | 1 |
| Moore, EE | 1 |
| Kerner, T | 1 |
| Ahlers, O | 1 |
| Veit, S | 1 |
| Riou, B | 1 |
| Saunders, M | 1 |
| Pison, U | 1 |
| SAPISOCHIN, E | 1 |
| van Iterson, M | 2 |
| Siegemund, M | 1 |
| Burhop, K | 4 |
| Ince, C | 2 |
| Malhotra, AK | 1 |
| Schweitzer, JB | 2 |
| Fox, JL | 1 |
| Fabian, TC | 2 |
| Proctor, KG | 2 |
| Jin, C | 1 |
| Wen-Fang, M | 1 |
| Min, H | 1 |
| Pei-Lin, C | 1 |
| Zhong-Yi, Y | 1 |
| Pape, A | 3 |
| Kleen, M | 3 |
| Kemming, G | 3 |
| Meisner, F | 3 |
| Meier, J | 1 |
| Habler, O | 3 |
| Kubulus, D | 1 |
| Rensing, H | 1 |
| Paxian, M | 1 |
| Thierbach, JT | 1 |
| Meisel, T | 1 |
| Redl, H | 1 |
| Bauer, M | 1 |
| Bauer, I | 1 |
| Bone, HG | 1 |
| Westphal, M | 1 |
| Hungerer, S | 1 |
| Nolte, D | 2 |
| Botzlar, A | 1 |
| Messmer, K | 5 |
| Casalnuovo, CA | 1 |
| Kraglund, K | 1 |
| Kristensen, IB | 1 |
| Amdrup, E | 1 |
| Larsen, KR | 1 |
| Jensen, NF | 1 |
| Davis, EK | 1 |
| Jensen, JC | 1 |
| Moody, FG | 2 |
| Mersereau, WA | 1 |
| Hinchey, EJ | 1 |
| Dunlap, E | 2 |
| Farrell, L | 2 |
| Nigro, C | 2 |
| Estep, T | 1 |
| Marchand, G | 2 |
| Schultz, SC | 3 |
| Hamilton, IN | 1 |
| Malcolm, DS | 3 |
| Powell, CC | 2 |
| Bernard, E | 1 |
| Leppäniemi, A | 1 |
| Soltero, R | 1 |
| Burris, D | 1 |
| Pikoulis, E | 1 |
| Ratigan, J | 1 |
| Waasdorp, C | 1 |
| Hufnagel, H | 1 |
| Malcolm, D | 1 |
| DeAngeles, DA | 1 |
| Scott, AM | 1 |
| McGrath, AM | 1 |
| Korent, VA | 1 |
| Rodenkirch, LA | 1 |
| Conhaim, RL | 1 |
| Harms, BA | 1 |
| de Figueiredo, LF | 1 |
| Mathru, M | 1 |
| Solanki, D | 1 |
| Macdonald, VW | 1 |
| Hess, J | 1 |
| Kramer, GC | 1 |
| Steinhauser, P | 1 |
| Pickelmann, S | 1 |
| Berger, S | 1 |
| Härtl, R | 1 |
| Wallace, JL | 1 |
| McKnight, W | 1 |
| Wilson, TL | 1 |
| Del Soldato, P | 1 |
| Cirino, G | 1 |
| Gulati, A | 2 |
| Sen, AP | 2 |
| Dong, Y | 1 |
| Saxena, PR | 1 |
| Sinaasappel, M | 1 |
| Trouwborst, A | 1 |
| Novak, L | 1 |
| Shackford, SR | 1 |
| Bourguignon, P | 1 |
| Nichols, P | 1 |
| Buckingham, S | 1 |
| Osler, T | 1 |
| Sartorelli, K | 1 |
| Gens, D | 2 |
| Cipolle, M | 2 |
| Runge, J | 2 |
| Mallory, MN | 2 |
| Rodman, G | 2 |
| von Dobschuetz, E | 1 |
| Hoffmann, T | 1 |
| Houghton, J | 2 |
| Nagy, K | 1 |
| Barrett, J | 1 |
| Freeman, BD | 1 |
| Danner, RL | 1 |
| Banks, SM | 1 |
| Natanson, C | 1 |
| Lewis, RJ | 1 |
| Berry, DA | 1 |
| Cryer, H | 1 |
| Fost, N | 1 |
| Krome, R | 1 |
| Washington, GR | 1 |
| Blue, JW | 1 |
| Bechhofer, R | 1 |
| Cook, T | 1 |
| Fisher, M | 1 |
| Gibson, JB | 1 |
| Maxwell, RA | 1 |
| Brunett, PH | 1 |
| Bynoe, RP | 1 |
| Morris, JA | 1 |
| Tinkoff, G | 1 |
| Dalsey, WC | 1 |
| Ochsner, MG | 1 |
| Zinner, MJ | 1 |
| Turtinen, L | 1 |
| Gurll, NJ | 1 |
| Svanes, K | 1 |
| Leiknes, KA | 1 |
| Varhaug, JE | 1 |
| Søreide, O | 1 |
| Noble, WH | 2 |
| Famewo, CE | 2 |
| Garvey, MB | 2 |
| Welter, H | 1 |
| Lauterjung, KL | 1 |
| Isselhard, W | 1 |
| Saggau, W | 1 |
| Bleyl, U | 1 |
| Brückner, UB | 1 |
| Klöss, T | 1 |
| Leinberger, H | 1 |
| Metzker, M | 1 |
| Schmier, J | 1 |
| Printz, H | 1 |
| Saluja, A | 1 |
| Leli, U | 1 |
| Sengupta, A | 1 |
| Steer, M | 1 |
| Kiviluoto, T | 1 |
| Voipio, J | 1 |
| Kivilaakso, E | 1 |
| Nelson, NC | 1 |
| Nelson, JL | 1 |
| Weldon, WE | 1 |
| Vela, AR | 1 |
| Skillman, JJ | 1 |
| Silen, W | 1 |
| Rundle, F | 1 |
| Ivey, KJ | 1 |
| Aldrete, JS | 1 |
4 reviews available for aspirin and Hemorrhagic Shock
| Article | Year |
|---|---|
Spontaneous splenic rupture in infectious mononucleosis: case report and review of the literature.
Topics: Abdominal Pain; Adolescent; Air Ambulances; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; | 2012 |
A proposed consent process in studies that use an exception to informed consent.
Topics: Aspirin; Emergency Treatment; Guidelines as Topic; Humans; Informed Consent; Injury Severity Score; | 1999 |
Gastric mucosal barriers.
Topics: Animals; Aspirin; Atropine; Bile Acids and Salts; Cats; Diffusion; Dilatation; Ethanol; Gastric Acid | 1972 |
Acute haemorrhagic gastritis: modern concepts based on pathogenesis.
Topics: Acute Disease; Aspirin; Blood Transfusion; Cell Membrane Permeability; Endoscopy; Gastrectomy; Gastr | 1971 |
4 trials available for aspirin and Hemorrhagic Shock
| Article | Year |
|---|---|
Emergency Resuscitation of Patients Enrolled in the US Diaspirin Cross-linked Hemoglobin (DCLHb) Clinical Efficacy Trial.
Topics: Adult; Airway Management; Aspirin; Blood Substitutes; Blood Transfusion; Emergency Treatment; Female | 2015 |
DCL-Hb for trauma patients with severe hemorrhagic shock: the European "On-Scene" multicenter study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Substitutes; European Union; Female; Flui | 2003 |
Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial.
Topics: Adult; Aspirin; Blood Substitutes; Female; Fluid Therapy; Hemoglobins; Humans; Logistic Models; Male | 1999 |
The informed consent process and the use of the exception to informed consent in the clinical trial of diaspirin cross-linked hemoglobin (DCLHb) in severe traumatic hemorrhagic shock. DCLHb Traumatic Hemorrhagic Shock study group.
Topics: Adult; Aspirin; Chi-Square Distribution; Clinical Trials as Topic; Female; Hemoglobins; Humans; Info | 1999 |
52 other studies available for aspirin and Hemorrhagic Shock
| Article | Year |
|---|---|
[Aneurysm of abdominal aorta rupture in a patient on dabigatran treatment].
Topics: Aged; Antithrombins; Aortic Aneurysm, Abdominal; Aortic Rupture; Arrhythmias, Cardiac; Aspirin; Benz | 2013 |
Heterochronic spontaneous rupture of bilateral renal cell carcinomas in a hemodialysis patient.
Topics: Anemia; Aspirin; Blood Transfusion; Carcinoma, Renal Cell; Glomerulonephritis; Hematuria; Humans; Ki | 2013 |
Shock index and prediction of traumatic hemorrhagic shock 28-day mortality: data from the DCLHb resuscitation clinical trials.
Topics: Adult; Aspirin; Blood Substitutes; Emergency Medical Services; Europe; Female; Fluid Therapy; Hemogl | 2014 |
The lack of consistent diaspirin cross-linked hemoglobin infusion blood pressure effects in the US and EU traumatic hemorrhagic shock clinical trials.
Topics: Adult; Aspirin; Blood Pressure; Clinical Trials as Topic; Female; Hemoglobins; Humans; Male; Middle | 2010 |
Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation.
Topics: Acidosis, Lactic; Adult; Aspirin; Emergency Medical Services; Emergency Treatment; Europe; Fluid The | 2010 |
The use of the Revised Trauma Score as an entry criterion in traumatic hemorrhagic shock studies: data from the DCLHb clinical trials.
Topics: Adult; Aspirin; Clinical Trials, Phase III as Topic; Female; Glasgow Coma Scale; Hemoglobins; Humans | 2012 |
Post hoc mortality analysis on the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shock.
Topics: Aspirin; Hemoglobins; Humans; Shock, Hemorrhagic; Shock, Traumatic; Survival Analysis | 2002 |
Blood substitutes: the future is now.
Topics: Aspirin; Blood Substitutes; Blood Transfusion; Clinical Trials as Topic; Erythrocytes; Forecasting; | 2003 |
The clinical trials of diaspirin cross-linked hemoglobin (DCLHb) in severe traumatic hemorrhagic shock: the tale of two continents.
Topics: Aspirin; Blood Substitutes; Clinical Trials as Topic; European Union; Hemoglobins; Humans; Shock, He | 2003 |
[ACUTE DIGESTIVE HEMORRHAGES].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticoagulants; Aspirin; Gastrointestinal Hemo | 1963 |
Hemoglobin-based oxygen carrier provides heterogeneous microvascular oxygenation in heart and gut after hemorrhage in pigs.
Topics: Analysis of Variance; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2003 |
Cerebral perfusion pressure elevation with oxygen-carrying pressor after traumatic brain injury and hypotension in Swine.
Topics: Amyloid beta-Protein Precursor; Animals; Aspirin; Blood Pressure; Blood Volume; Brain Chemistry; Bra | 2004 |
Chemically modified porcine hemoglobins and their biological properties.
Topics: Allosteric Regulation; Animals; Aspirin; Blood Substitutes; Cross-Linking Reagents; Disease Models, | 2004 |
Fluid resuscitation from severe hemorrhagic shock using diaspirin cross-linked hemoglobin fails to improve pancreatic and renal perfusion.
Topics: Algorithms; Animals; Aspirin; Blood Substitutes; Female; Fluid Therapy; Hemoglobins; Male; Microsphe | 2004 |
Influence of heme-based solutions on stress protein expression and organ failure after hemorrhagic shock.
Topics: Animals; Aspirin; Blood Substitutes; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); | 2005 |
The prospect of hemoglobin-based blood substitutes: Still a long stony road to go.
Topics: Animals; Aspirin; Blood Substitutes; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hemoglob | 2005 |
Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on microcirculation and local tissue pO2 of striated skin muscle following resuscitation from hemorrhagic shock.
Topics: Animals; Aspirin; Blood Flow Velocity; Blood Substitutes; Cell Adhesion; Cricetinae; Endothelium, Va | 2006 |
Canine gastric ulcer produced by hemorrhagic shock and aspirin.
Topics: Acids; Animals; Aspirin; Dogs; Female; Gastric Mucosa; Male; Shock, Hemorrhagic; Stomach; Stomach Ul | 1984 |
The cytoprotective effects of (+/-)-15-deoxy-16-alpha, beta-hydroxy-16-methyl PGE1 methyl ester (sc-29333) versus aspirin-shock gastric ulcerogenesis in the dog.
Topics: Animals; Aspirin; Dogs; Gastric Mucosa; Misoprostol; Prostaglandins E, Synthetic; Shock, Hemorrhagic | 1981 |
Role of gastric mucosal folds in formation of focal ulcers in the rat.
Topics: Action Potentials; Animals; Aspirin; Disease Models, Animal; Gastric Mucosa; Ischemia; Permeability; | 1982 |
Resuscitation with Diaspirin Crosslinked Hemoglobin in a pig model of hemorrhagic shock.
Topics: Animals; Aspirin; Blood Pressure Determination; Creatinine; Enzymes; Hematocrit; Hemoglobins; Isoton | 1995 |
Use of base deficit to compare resuscitation with lactated Ringer's solution, Haemaccel, whole blood, and diaspirin cross-linked hemoglobin following hemorrhage in rats.
Topics: Acid-Base Equilibrium; Animals; Aspirin; Disease Models, Animal; Hemoglobins; Isotonic Solutions; Ma | 1993 |
Diaspirin crosslinked hemoglobin (DCLHb) attenuates bacterial translocation in rats.
Topics: Animals; Aspirin; Bacteria; Biological Transport; Blood Substitutes; Depression, Chemical; Hemoglobi | 1995 |
Early resuscitation with low-volume PolyDCLHb is effective in the treatment of shock induced by penetrating vascular injury.
Topics: Animals; Aorta; Arteries; Aspirin; Blood Pressure; Dose-Response Relationship, Drug; Fluid Therapy; | 1996 |
Diaspirin crosslinked hemoglobin (DCLHb): more effective than lactated Ringer's solution in restoring central venous oxygen saturation after hemorrhagic shock in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Hemoglobins; Isotonic Solutions; Jugular Veins; Male; Oxyg | 1996 |
Resuscitation with increasing doses of diaspirin crosslinked hemoglobin in swine.
Topics: Animals; Aspirin; Blood Chemical Analysis; Blood Substitutes; Dose-Response Relationship, Drug; Hemo | 1996 |
Resuscitation from hemorrhagic shock with diaspirin cross-linked hemoglobin, blood, or hetastarch.
Topics: Animals; Aspirin; Blood Gas Analysis; Blood Substitutes; Blood Transfusion, Autologous; Hemodynamics | 1997 |
Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes.
Topics: Albumins; Animals; Aspirin; Cerebrovascular Circulation; Constriction, Pathologic; Disease Models, A | 1997 |
Effects of diaspirin-cross-linked hemoglobin (DCLHb) on local tissue oxygen tension in striated skin muscle: an efficacy study in the hamster.
Topics: Animals; Aspirin; Blood Substitutes; Blood Volume; Cricetinae; Exchange Transfusion, Whole Blood; He | 1997 |
Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils.
Topics: Animals; Aspirin; Cell Adhesion; Gastric Mucosa; Male; Neutrophils; Nitric Oxide; Nitroglycerin; Pla | 1997 |
Dose-dependent effect of diaspirin cross-linked hemoglobin on regional blood circulation of severely hemorrhaged rats.
Topics: Acid-Base Equilibrium; Animals; Aspirin; Blood Substitutes; Dose-Response Relationship, Drug; Drug E | 1998 |
Modulation of resuscitative effect of diaspirin cross-linked hemoglobin by L-NAME in rats.
Topics: Animals; Arginine; Aspirin; Hemodynamics; Hemoglobins; Male; NG-Nitroarginine Methyl Ester; Nitric O | 1998 |
Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine.
Topics: Animals; Aspirin; Blood Substitutes; Disease Models, Animal; Female; Hemodynamics; Hemoglobins; Ileu | 1998 |
Comparison of standard and alternative prehospital resuscitation in uncontrolled hemorrhagic shock and head injury.
Topics: Animals; Aspirin; Blood Substitutes; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Em | 1999 |
Diaspirin cross-linked hemoglobin effectively restores pancreatic microcirculatory failure in hemorrhagic shock.
Topics: Acid-Base Equilibrium; Animals; Aspirin; Blood Substitutes; Cell Adhesion; Cross-Linking Reagents; E | 1999 |
Effects of primary resuscitation from shock on distribution of myocardial blood flow.
Topics: Animals; Aspirin; Coronary Circulation; Coronary Vessels; Hemodynamics; Hemoglobins; Humans; Hypoten | 2000 |
Diaspirin-crosslinked hemoglobin reduces mortality of severe hemorrhagic shock in pigs with critical coronary stenosis.
Topics: Animals; Aspirin; Blood Substitutes; Coronary Disease; Female; Hemoglobins; Male; Random Allocation; | 2000 |
Safeguarding patients in clinical trials with high mortality rates.
Topics: Aspirin; Blood Substitutes; Clinical Trials as Topic; Critical Illness; Hemoglobins; Human Growth Ho | 2001 |
Monitoring a clinical trial conducted under the Food and Drug Administration regulations allowing a waiver of prospective informed consent: the diaspirin cross-linked hemoglobin traumatic hemorrhagic shock efficacy trial.
Topics: Aspirin; Critical Illness; Female; Follow-Up Studies; Hemoglobins; Humans; Informed Consent; Injury | 2001 |
Resuscitation from severe hemorrhagic shock after traumatic brain injury using saline, shed blood, or a blood substitute.
Topics: Animals; Aspirin; Blood Substitutes; Blood Transfusion; Brain; Brain Injuries; Brain Ischemia; Carbo | 2002 |
Post hoc mortality analysis of the efficacy trial of diaspirin cross-linked hemoglobin in the treatment of severe traumatic hemorrhagic shock.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Female; Hemoglobins; Humans; Male; Middle Aged; | 2002 |
Stress ulceration and the gastric mucosal barrier.
Topics: Animals; Aspirin; Bile Acids and Salts; Cats; Disease Models, Animal; Ethanol; Gastric Acidity Deter | 1975 |
Aspirin damage to ischemic gastric mucosa in shocked cats.
Topics: Administration, Topical; Animals; Aspirin; Cardiac Output; Cats; Female; Gastric Mucosa; Ischemia; M | 1979 |
Pulmonary vascular effects of acetylsalicylic acid, chloroquine, dextran and methylprednisolone given after haemorrhagic shock in dogs.
Topics: Animals; Aspirin; Blood Coagulation; Chloroquine; Dextrans; Dogs; Hemodynamics; Lung; Methylpredniso | 1977 |
[Inhibition of thrombocyte aggregation in hemorrhagic shock using acetylsalicylic acid and mechanical ventilation].
Topics: Animals; Arteries; Aspirin; Blood Flow Velocity; Dogs; Platelet Aggregation; Respiration, Artificial | 1978 |
[Pulmonary hemodynamics, coagulation and morphological changes in the lung after thrombocyte aggregation inhibition and intravasal coagulation in experimental trauma and hemorrhagic shock].
Topics: Airway Resistance; Animals; Aspirin; Dipyridamole; Dogs; Hemodynamics; Lung; Platelet Aggregation; S | 1976 |
Use of aspirin in haemorrhagic shock.
Topics: Animals; Aspirin; Bicarbonates; Blood Coagulation Factors; Blood Pressure; Carbon Dioxide; Cardiac O | 1975 |
Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis.
Topics: Amylases; Animals; Aspirin; Blood Pressure; Cathepsin B; Ceruletide; Disease Models, Animal; Ethanol | 1990 |
Subepithelial tissue pH of rat gastric mucosa exposed to luminal acid, barrier breaking agents, and hemorrhagic shock.
Topics: Animals; Aspirin; Epithelium; Ethanol; Female; Gastric Acid; Gastric Mucosa; Hydrochloric Acid; Hydr | 1988 |
Mechanisms of change in thoracic duct lymph flow during hypotensive states.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspirin; Capillary Permeability; | 1970 |
The dilemma of a prison doctor.
Topics: Anesthesia; Arthritis; Aspirin; Behavior Therapy; Delivery of Health Care; Fluphenazine; Hostility; | 1972 |
Hydrogen permeability of canine gastric secretory epithelium during formation of acute superficial erosions.
Topics: Animals; Aspirin; Biological Transport; Dogs; Female; Gastric Mucosa; Hydrogen; Male; Potassium; Sho | 1971 |