aspirin and Hemorrhage, Peptic Ulcer studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Research Excerpts

Excerpt	Relevance	Reference
"H pylori eradication protects against aspirin-associated peptic ulcer bleeding, but this might not be sustained in the long term."	9.51	Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. ( Avery, A; Coupland, CAC; Crooks, C; Dumbleton, J; Hawkey, C; Hobbs, FDR; Kendrick, D; Moore, M; Morris, C; Rubin, G; Smith, M; Stevenson, D, 2022)
"For this industry-independent, double-blind, double-dummy, randomised trial done in one academic hospital in Hong Kong, we screened patients with arthritis and cardiothrombotic diseases who were presenting with upper gastrointestinal bleeding, were on NSAIDs, and require concomitant aspirin."	9.24	Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. ( Au, KWL; Chan, FKL; Chan, H; Cheong, PK; Ching, JYL; Kee, KM; Kyaw, MH; Lam, K; Lee, V; Lo, A; Ng, SC; Suen, BY; Tse, YK; Wong, GLH; Wong, VWS; Wu, JCY, 2017)
" As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's."	9.15	Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. ( Chen, LC; Hou, MC; Huang, KW; Lee, FY; Lee, SD; Leu, HB; Li, CP; Lin, HC; Lu, CL; Luo, JC, 2011)
"Clopidogrel causes significantly less symptomatic peptic ulcer disease and gastrointestinal bleeding than low-dose aspirin in average-risk patients."	9.11	Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. ( Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY, 2004)
"Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer."	9.06	The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. ( Abbey, DE; Kurata, JH, 1990)
"The CHST2 2082 T allele as well as SLCO1B11b haplotype may identify patients at increased risk for aspirin*-induced peptic ulcer or ulcer bleeding."	7.80	Single nucleotide polymorphism markers for low-dose aspirin-associated peptic ulcer and ulcer bleeding. ( Fujimura, Y; Fujita, Y; Haruma, K; Murao, T; Nishio, K; Sakakibara, T; Shiotani, A, 2014)
"H pylori eradication protects against aspirin-associated peptic ulcer bleeding, but this might not be sustained in the long term."	5.51	Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. ( Avery, A; Coupland, CAC; Crooks, C; Dumbleton, J; Hawkey, C; Hobbs, FDR; Kendrick, D; Moore, M; Morris, C; Rubin, G; Smith, M; Stevenson, D, 2022)
"For this industry-independent, double-blind, double-dummy, randomised trial done in one academic hospital in Hong Kong, we screened patients with arthritis and cardiothrombotic diseases who were presenting with upper gastrointestinal bleeding, were on NSAIDs, and require concomitant aspirin."	5.24	Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. ( Au, KWL; Chan, FKL; Chan, H; Cheong, PK; Ching, JYL; Kee, KM; Kyaw, MH; Lam, K; Lee, V; Lo, A; Ng, SC; Suen, BY; Tse, YK; Wong, GLH; Wong, VWS; Wu, JCY, 2017)
" As a result, clopidogrel's incidence of peptic ulcer disease (PUD) and ulcer bleeding is lower than aspirin's."	5.15	Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. ( Chen, LC; Hou, MC; Huang, KW; Lee, FY; Lee, SD; Leu, HB; Li, CP; Lin, HC; Lu, CL; Luo, JC, 2011)
"Clopidogrel causes significantly less symptomatic peptic ulcer disease and gastrointestinal bleeding than low-dose aspirin in average-risk patients."	5.11	Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. ( Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY, 2004)
"This analysis compared the efficacy of misoprostol, lansoprazole, and placebo in reducing the risk of gastric or duodenal ulcer recurrence in patients taking NSAIDs and low-dose aspirin."	5.11	Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. ( Amer, F; Christopoulos, NG; Goldstein, JL; Huang, B, 2004)
"Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer."	5.06	The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. ( Abbey, DE; Kurata, JH, 1990)
" pylori infection and low-dose aspirin (LDA) are not only independent causal factors of peptic ulcer and gastrointestinal bleeding, they also have synergistic and additive effects."	4.86	[Influence of H. pylori infection on upper gastrointestinal damage]. ( Fukuzawa, M; Kawai, T; Moriyasu, F; Yamashina, A, 2010)
"Based on current references four clinical scenarios were discussed and different management strategies were compared for secondary and primary prophylaxis of ulcer or peptic ulcer bleeding under continuous therapy with non-steroidal antiinflammatory drugs (NSAID) or low-dose-aspirin, for H."	4.82	[Secondary and primary prophylaxis of gastropathy associated with nonsteroidal antiinflammatory drugs or low-dose-aspirin: a review based on four clinical scenarios]. ( Ittel, TH; Limmer, S; Wietholtz, H, 2003)
" Cox proportional hazard regression models were developed to evaluate the predictors of LGIB with adjustments for age, gender, comorbidities including coronary artery disease, ischaemic stroke, diabetes, hypertension, chronic kidney disease, liver cirrhosis, chronic obstructive pulmonary disease, dyslipidemia, uncomplicated peptic ulcer disease, history of peptic ulcer bleeding, and concomitant use of clopidogrel, ticlopidine, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors, steroids, proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), nitrates, alendronate, selective serotonin reuptake inhibitors (SSRIs) and calcium channel blockers."	3.85	The risk of lower gastrointestinal bleeding in low-dose aspirin users. ( Chen, WC; Chuah, SK; Hsu, PI; Huang, YT; Lin, KH; Sun, WC; Tsai, TJ; Wu, DC, 2017)
"96) as well as history of hematemesis, melena in the past 30 days, positive nasogastric aspirate, prior upper gastrointestinal bleeding or use of aspirin or non-steroidal anti-inflammatory."	3.83	Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. ( Camus, M; Dulai, GS; Ghassemi, KA; Jensen, DM; Jutabha, R; Khungar, V; Kovacs, TO; Machicado, GA; Ohning, GV, 2016)
"The main innovations of the latest meeting of the Gastroenterological Association (2016) concerning upper gastrointestinal bleeding from the clinician's perspective can be summarised as follows: a) The Glasgow-Blatchford scale has the best accuracy in predicting the need for surgical intervention and hospital mortality; b) Prognostic scales for non-variceal upper gastrointestinal bleeding are also useful for lower gastrointestinal bleeding; c) Preliminary data suggest that treatment with hemospray does not seem to be superior to current standard treatment in controlling active peptic ulcer bleeding; d) Either famotidine or a proton pump inhibitor may be effective in preventing haemorrhagic recurrence in patients taking aspirin, but this finding needs to be confirmed in further studies; e) There was confirmation of the need to re-introduce antiplatelet therapy as early as possible in patients with antiplatelet-associated gastrointestinal bleeding in order to prevent cardiovascular mortality; f) Routine clinical practice suggests that gastrointestinal or cardiovascular complications with celecoxib or traditional NSAIDs are very low; g) Dabigatran is associated with an increased incidence of gastrointestinal bleeding compared with apixaban or warfarin."	3.83	Advances in gastrointestinal bleeding. ( Lanas, Á, 2016)
"The CHST2 2082 T allele as well as SLCO1B11b haplotype may identify patients at increased risk for aspirin*-induced peptic ulcer or ulcer bleeding."	3.80	Single nucleotide polymorphism markers for low-dose aspirin-associated peptic ulcer and ulcer bleeding. ( Fujimura, Y; Fujita, Y; Haruma, K; Murao, T; Nishio, K; Sakakibara, T; Shiotani, A, 2014)
"Low-dose aspirin (ASA) has emerged as one of the most important causes of peptic ulcer bleeding in developed countries."	3.78	Anti-platelet therapy and managing ulcer risk. ( Chan, FK, 2012)
"The aim of this study was to examine the genotypes of RAS genes related to the risk of peptic ulcer and ulcer bleeding among patients taking low dose aspirin."	3.77	Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin: renin angiotensin system genes' polymorphism. ( Haruma, K; Kamada, T; Matsumoto, H; Murao, T; Nishi, R; Sakakibara, T; Shiotani, A; Tarumi, K; Yamanaka, Y, 2011)
"Advanced age, atherosclerosis, male gender and NSAID administration (particularly aspirin) are the major risk factors of upper GI hemorrhage in patients with gastric and/or duodenal ulcer."	3.77	Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. ( Akkız, H; Coşar, A; Ozdil, B; Sandıkçı, M, 2011)
"We present the case of a patient taking aspirin and etoricoxib who was admitted with upper digestive haemorrhage due to duodenal ulcer."	3.75	Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors. ( Soares, J, 2009)
"To determine the risk of peptic ulcer upper gastrointestinal bleeding (UGIB) associated with the use of coxibs, traditional NSAIDs, aspirin or combinations of these drugs in clinical practice."	3.73	Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. ( Arroyo, MT; Bástida, G; Borda, F; de Argila, CM; Feu, F; García-Rodríguez, LA; Gomollón, F; González-Pérez, A; Güell, M; Lanas, A; Piqué, JM; Quintero, E; Rodrigo, L; Santolaria, S; Zapata, E, 2006)
"Studies were performed in three models of acute gastric mucosal damage (induced by oral ethanol, aspirin and indomethacin) and a model of chronic gastritis (induced by 7 day treatment with iodoacetamide) in rats to establish the role of leukotrienes (LTs) in the pathogenesis of these lesions."	3.69	Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. ( Gyömber, E; Rainsford, KD; Szabo, S; Vattay, P, 1996)
"Low-dose aspirin is widely used in patients operated on for coronary disease as secondary prevention of coronary artery occlusion."	3.68	Gastric changes in coronary-operated patients with low-dose aspirin. ( Kivilaakso, E; Leivonen, M; Sipponen, P, 1992)
"A case-control study was performed to determine whether aspirin confers a similar risk of bleeding from gastric or duodenal ulcers in the elderly as non-aspirin, non-steroidal anti-inflammatory drugs."	3.67	Aspirin and bleeding peptic ulcers in the elderly. ( Faulkner, G; Langman, MJ; Prichard, P; Somerville, K, 1988)
" Taking aspirin is exceptional before rupture of esophageal varices."	3.65	[Clinical aspects and course of drug-induced upper digestive hemorrhage]. ( Benarous, JJ; Frexinos, J; Legrand, G; Pascal, JP; Ribet, A; Suduca, P; Tournut, R, 1976)
" If both Clopidogrel and PPI need to be prescribed, a split dosage regimen of PPI in the morning and clopidogrel in the evening can be recommended."	2.46	[Dilemma between gastroprotection and cardiovascular prevention]. ( Kandulski, A; Malfertheiner, P; Venerito, M, 2010)
" Chronic use is associated with uncomplicated gastric ulcer (but not clearly with uncomplicated duodenal ulcer) and with presentation with haematemesis and melaena."	2.39	Review article: aspirin and gastrointestinal bleeding. ( Hawkey, CJ, 1994)
"Acute gastroduodenal ulcer bleeding is a life-threatening condition."	1.91	[Recent aspects of pharmaceutical and endoscopic treatment of acute gastroduodenal ulcer bleeding]. ( Rácz, I, 2023)
"Aspirin was used by 16/48 (33."	1.40	Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs. ( Djuranović, S; Golubović, M; Milicić, B; Smolović, B; Stanisavljević, D; Vucković, L, 2014)
"The prevalence of ulcers or erosion during chronic use of LDA, LDA and the anti-platelet drug thienopyridine (clopidogrel or ticlopidine), and NSAIDs were 64."	1.40	Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding. ( Honda, A; Ikegami, T; Iwamoto, J; Matsuzaki, Y; Mizokami, Y; Saito, Y; Shimokobe, K, 2014)
"With aspirin, however, it has long been believed that it is difficult to induce any damage in the intestinal mucosa of laboratory animals."	1.36	New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. ( Amagase, K; Nakagawa, K; Nakamura, M; Nonoyama, K; Okabe, S; Takeuchi, K, 2010)
"When ticlopidine was administered 1h after EtOH, it significantly (p<0."	1.34	Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007)
"In addition, diverticular bleeding in the elderly was highly associated with intake of Aspirin."	1.33	[Epidemiology of gastrointestinal bleeding in the elderly]. ( Bertschinger, P; Bühler, H; Geyer, M; Stamenic, I, 2006)
"The corticosterone production was inhibited by a single large dose of cortisol as well as by an adrenalectomy."	1.31	[The role of endogenous glucocorticoids in maintenance of the gastric mucosa integrity]. ( Bagaeva, TP; Filaretova, LP, 2000)
"One hundred consecutive cases of upper gastrointestinal hemorrhage were studied clinically, radiologically and endoscopically."	1.26	Upper gastrointestinal hemorrhage clinical, radiological and endoscopic correlation of 100 consecutive cases. ( Dinoso, VP; Lorber, SH; Meshkinpour, H, 1976)

Research

Studies (202)

Authors

Clinical Trials (15)

Trial Overview

Trial Outcomes

Number of Participants With Healed Peptic Ulcer

Timeframe	Studies, this research(%)	All Research%
pre-1990	67 (33.17)	18.7374
1990's	17 (8.42)	18.2507
2000's	58 (28.71)	29.6817
2010's	51 (25.25)	24.3611
2020's	9 (4.46)	2.80

Authors	Studies
Lanas, A	10
Santilli, F	1
Hawkey, C	1
Avery, A	1
Coupland, CAC	1
Crooks, C	1
Dumbleton, J	1
Hobbs, FDR	1
Kendrick, D	1
Moore, M	1
Morris, C	1
Rubin, G	1
Smith, M	1
Stevenson, D	1
Yadlapati, R	2
Perisetti, A	1
Sharma, P	1
Alhalabi, MM	1
Rácz, I	1
Yang, HJ	1
Yang, SC	2
Wu, CK	2
Tai, WC	2
Liang, CM	2
Yao, CC	1
Wu, KL	1
Hsu, CN	2
Chuah, SK	3
Haastrup, PF	1
Hansen, JM	5
Søndergaard, J	1
Jarbøl, DE	1
Chan, FKL	2
Ching, JYL	2
Tse, YK	4
Lam, K	3
Wong, GLH	1
Ng, SC	2
Lee, V	3
Au, KWL	1
Cheong, PK	3
Suen, BY	3
Chan, H	2
Kee, KM	2
Lo, A	2
Wong, VWS	1
Wu, JCY	1
Kyaw, MH	2
Chen, WC	1
Lin, KH	1
Huang, YT	1
Tsai, TJ	1
Sun, WC	2
Wu, DC	2
Hsu, PI	2
Kawasaki, K	1
Nakamura, S	1
Kurahara, K	1
Nagasue, T	1
Yanai, S	1
Harada, A	1
Yaita, H	1
Fuchigami, T	1
Matsumoto, T	3
Jawaid, H	1
Hussain, A	1
Imtiaz, F	1
Siau, K	1
Hannah, JL	1
Hodson, J	1
Widlak, M	1
Bhala, N	1
Iqbal, TH	1
Aoki, T	2
Yamada, A	1
Hirata, Y	1
Suzuki, H	1
Nakada, A	1
Niikura, R	2
Seto, M	1
Okamoto, M	1
Koike, K	1
Taha, AS	1
McCloskey, C	1
McSkimming, P	1
McConnachie, A	1
Otani, K	1
Higashimori, A	1
Watanabe, T	2
Tanigawa, T	2
Fujiwara, Y	1
Arakawa, T	2
Fukushi, K	1
Tominaga, K	1
Nagashima, K	1
Kanamori, A	1
Izawa, N	1
Kanazawa, M	1
Sasai, T	1
Hiraishi, H	1
Ng, JC	1
Yeomans, ND	1
Sostres, C	3
Glaser, J	1
Takeuchi, K	2
Izuhara, C	1
Takayama, S	1
Momode, T	1
Kojo, M	1
Hara, D	1
Amagase, K	2
Labenz, J	1
Lin, CC	1
Hu, HY	1
Luo, JC	3
Peng, YL	2
Hou, MC	3
Lin, HC	3
Lee, FY	3
Higuchi, T	1
Iwakiri, R	1
Hara, M	1
Shimoda, R	1
Sakata, Y	2
Nakayama, A	1
Nio, K	1
Yamaguchi, S	1
Yamaguchi, D	1
Watanabe, A	1
Akutagawa, T	1
Sakata, H	1
Fujimoto, K	2
Abu Daya, H	1
Eloubeidi, M	1
Tamim, H	1
Halawi, H	1
Malli, AH	1
Rockey, DC	1
Barada, K	1
Smolović, B	1
Stanisavljević, D	1
Golubović, M	1
Vucković, L	1
Milicić, B	1
Djuranović, S	1
Pottegård, A	1
Kviesgaard, AK	1
Hesse, U	1
Moreno, SI	1
Iwamoto, J	1
Mizokami, Y	1
Saito, Y	1
Shimokobe, K	1
Honda, A	1
Ikegami, T	1
Matsuzaki, Y	1
Nagata, N	1
Sekine, K	1
Sakurai, T	1
Shimbo, T	1
Kishida, Y	1
Tanaka, S	1
Okubo, H	1
Watanabe, K	1
Yokoi, C	1
Akiyama, J	1
Yanase, M	1
Mizokami, M	1
Uemura, N	1
Laursen, SB	1
Jørgensen, HS	1
Schaffalitzky de Muckadell, OB	1
Shiotani, A	3
Murao, T	2
Fujita, Y	1
Fujimura, Y	2
Sakakibara, T	3
Nishio, K	1
Haruma, K	3
Carrera-Lasfuentes, P	1
Benito, R	1
Roncales, P	1
Arruebo, M	1
Arroyo, MT	2
Bujanda, L	1
García-Rodríguez, LA	2
Telaku, S	1
Kraja, B	1
Qirjako, G	1
Prifti, S	1
Fejza, H	1
Kaehler, G	1
Dutenhoefner, C	1
Magdeburg, R	1
Mo, C	1
Sun, G	1
Lu, ML	1
Zhang, L	1
Wang, YZ	1
Sun, X	1
Yang, YS	1
Tseng, CL	1
Chen, YT	1
Huang, CJ	1
Huang, DF	1
Chung, WC	1
Jeon, EJ	1
Kim, DB	1
Sung, HJ	1
Kim, YJ	1
Lim, ES	1
Kim, MA	1
Oh, JH	1
Kim, SH	1
Jung, JT	1
Kwon, JG	1
Kim, EY	1
Lee, DW	1
Jeon, SW	1
Park, KS	1
Lee, SH	1
Park, JB	1
Ha, CY	1
Park, YS	1
Camus, M	1
Khungar, V	1
Jensen, DM	1
Ohning, GV	1
Kovacs, TO	1
Jutabha, R	1
Ghassemi, KA	1
Machicado, GA	1
Dulai, GS	1
Shih, CW	1
Ku, MK	1
Yuan, LT	1
Wang, JW	1
Tseng, KL	1
Hung, TH	1
Nguang, SH	1
Chan, FK	5
Kyaw, M	1
Higuchi, K	1
Kinoshita, Y	1
Naito, Y	2
Ching, JY	3
Lui, R	1
Tang, RS	1
Takeuchi, T	1
Handa, O	1
Nebiki, H	1
Wu, JC	3
Abe, T	1
Mishiro, T	1
Vestergård, A	1
Bredahl, K	1
de Muckadell, OB	1
Pedersen, OB	1
Nardulli, G	1
Lanza, FL	1
Quigley, EM	2
Dai, X	1
Makaryus, AN	1
Makaryus, JN	1
Jauhar, R	1
Chiu, PW	1
Ng, EK	1
Cryer, B	2
Beales, IL	1
Whelan, CT	1
Kaboli, P	1
Zhang, Q	1
Siddique, J	1
Ye, S	1
Meltzer, DO	1
Soares, J	1
Pilotto, A	2
Franceschi, M	2
Maggi, S	1
Addante, F	1
Sancarlo, D	1
Nonoyama, K	1
Nakagawa, K	1
Nakamura, M	1
Okabe, S	1
Åhsberg, K	1
Höglund, P	1
Staël von Holstein, C	1
Nishi, R	1
Yamanaka, Y	1
Matsumoto, H	1
Tarumi, K	1
Kamada, T	2
Schaffer, AC	1
Grad, Y	1
Ross, JJ	1
Venerito, M	1
Kandulski, A	1
Malfertheiner, P	2
Grad, YH	1
Seifter, JL	1
Levy, BD	1
Loscalzo, J	1
Kawai, T	1
Fukuzawa, M	1
Moriyasu, F	1
Yamashina, A	1
Komarov, AL	1
Ozdil, B	1
Coşar, A	1
Akkız, H	1
Sandıkçı, M	1
Xia, ZW	1
Ma, LL	1
Yao, W	1
Huang, KW	1
Leu, HB	1
Chen, LC	1
Li, CP	1
Lu, CL	1
Lee, SD	1
Manabe, N	1
Dworzynski, K	1
Pollit, V	1
Kelsey, A	1
Higgins, B	1
Palmer, K	1
Sung, JJ	3
Gharzouli, K	1
Amira, S	1
Gharzouli, A	1
Khennouf, S	1
Zeidler, H	1
Bolten, WW	1
Langman, M	2
Shostak, NA	1
Riabkova, AA	1
Savel'ev, VS	1
Maliarova, LP	1
Limmer, S	1
Ittel, TH	1
Wietholtz, H	1
DARMAILLACQ, R	1
PELLET, C	1
LEROY, P	1
LEVRAT, M	3
LAMBERT, R	2
ETIENNE-MARTIN, P	1
KLEPPING, C	1
BINET, J	1
DOUGLAS, RA	1
JOHNSTON, ED	1
BRICK, IB	1
SAPISOCHIN, E	1
BANNERMAN, RM	1
BEVERIDGE, BR	1
WITTS, LJ	1
JANBON, M	1
FLANDRE, O	1
DAMON, M	1
FRANCOIS, P	1
PEILLEX, F	1
JENNINGS, GH	1
MUIR, A	1
COSSAR, IA	1
Hunt, RH	1
Bazzoli, F	1
Ng, FH	1
Wong, BC	3
Wong, SY	1
Chen, WH	1
Chang, CM	1
Jayaprakash, A	1
McGrath, C	1
McCullagh, E	1
Smith, F	1
Angelini, G	1
Probert, C	1
Leandro, G	1
Longo, MG	1
Perri, F	1
Scarcelli, C	1
Goldstein, JL	1
Huang, B	1
Amer, F	1
Christopoulos, NG	1
Hung, LC	1
Wong, VW	1
Leung, VK	1
Kung, NN	1
Hui, AJ	1
Leung, WK	1
Lee, VW	1
Lee, KK	1
Lee, YT	1
Lau, JY	1
To, KF	1
Chan, HL	1
Chung, SC	1
Bobrzyński, A	1
Konturek, PC	1
Konturek, SJ	3
Płonka, M	1
Bielański, W	1
Karcz, D	1
Maywald, U	1
Schindler, C	1
Wolk, MJ	1
Jacobs, AK	1
Barski, PR	1
Wargo, KA	1
Baty, SR	1
Knowles, G	1
Di Fiore, F	1
Lecleire, S	1
Merle, V	1
Hervé, S	1
Duhamel, C	1
Dupas, JL	2
Vandewalle, A	1
Bental, A	1
Gouerou, H	1
Le Page, M	1
Amouretti, M	1
Czernichow, P	1
Lerebours, E	1
Kulbertus, H	1
Nakashima, S	1
Arai, S	1
Mizuno, Y	1
Yoshino, K	1
Ando, S	1
Nakamura, Y	2
Sugawara, K	1
Koike, M	1
Saito, E	1
Naito, M	1
Nakao, M	1
Ito, H	1
Hamaoka, K	1
Rai, F	1
Asakura, Y	1
Akamatu, M	1
Fujimori, K	1
Inao, M	1
Imai, Y	1
Ota, S	1
Fujiwara, K	1
Shiibashi, M	1
Nitschmann, S	1
Mössner, J	1
Rossini, R	1
Lucà, MG	1
Scuri, P	1
Invernizzi, P	1
Strazzabosco, M	1
Gavazzi, A	1
Scheiman, JM	1
Agustí-Escasany, A	1
Vallano-Ferraz, A	1
Fass, R	1
Modlin, IM	1
Malagelada, JR	1
Moss, SF	1
Holtmann, G	1
Goh, KL	1
Katelaris, P	1
Stanghellini, V	1
Talley, NJ	1
Tytgat, GN	1
Wright, NA	1
Gomollón, F	1
Feu, F	1
González-Pérez, A	1
Zapata, E	1
Bástida, G	1
Rodrigo, L	1
Santolaria, S	1
Güell, M	1
de Argila, CM	1
Quintero, E	1
Borda, F	1
Piqué, JM	1
Geyer, M	1
Stamenic, I	1
Bühler, H	1
Bertschinger, P	1
Lai, KC	2
Chu, KM	2
Hui, WM	2
Hung, WK	1
Loo, CK	1
Hu, WH	2
Chan, AO	2
Kwok, KF	1
Fung, TT	1
Wong, J	2
Lam, SK	2
Stiefelhagen, P	1
Hallas, J	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Double-blind Randomized Comparison of Celecoxib Plus Esomeprazole Versus Naproxen Plus Esomeprazole for Prevention of Recurrent Ulcer Bleeding in Patients With Arthritis and Cardiothrombotic Diseases (NSAID#8 Study)[NCT00153660]	Phase 3	514 participants (Actual)	Interventional	2005-06-30	Completed
Misoprostol for the Healing of Small Bowel Ulceration in Patients With Obscure Blood Loss While Taking Low-dose Aspirin or Nonsteroidal Antiinflammatory Drugs [MASTERS Trial][NCT02202967]	Phase 3	104 participants (Actual)	Interventional	2016-01-07	Completed
A Double-blind, Randomized, Placebo Controlled Trial of Misoprostol for Healing of Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding (MISO-SB Study)[NCT01998776]	Phase 2/Phase 3	82 participants (Actual)	Interventional	2013-04-30	Completed
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction Trial Based on the SWEDEHEART Registry (HELP-SWEDEHEART)[NCT05024864]		22,000 participants (Anticipated)	Interventional	2021-11-17	Recruiting
Sclerotherapy With Polidocanol Foam in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease in Patients With Liver Cirrhosis: A Prospective, Cohort Trial[NCT05807425]	Phase 2/Phase 3	40 participants (Anticipated)	Interventional	2023-03-31	Recruiting
Video Capsule Endoscopy for Lesion Localization and Diagnosis in Patients With Severe Hematochezia[NCT03616041]		50 participants (Anticipated)	Observational	2021-02-10	Recruiting
Histamine-2 Receptor Antagonist Versus Proton-Pump Inhibitor for the Prevention of Recurrent Upper Gastrointestinal Bleeding (UGI) in High-risk Users of Low-dose Aspirin (ASA)[NCT01408186]	Phase 3	264 participants (Actual)	Interventional	2011-01-31	Completed
Efficacy and Safety of Hou Gu Mi Xi in Patients With Peptic Ulcer Diseases: A Multicenter, Randomized, Double-blinded, Controlled Trial[NCT03320538]		360 participants (Anticipated)	Interventional	2017-07-10	Recruiting
Comparison of Ulcer Healing in Patients Taking Rabeprazole Plus Aspirin Versus Rabeprazole Plus Clopidogrel for Acute Peptic Ulcer[NCT01037491]		200 participants (Anticipated)	Interventional	2009-10-31	Recruiting
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction Pilot Study[NCT04289012]		300 participants (Actual)	Interventional	2019-11-07	Completed
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309]		30 participants (Anticipated)	Interventional	2006-04-30	Completed
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312]		228 participants (Actual)	Interventional	2012-01-31	Completed
Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744]		101 participants (Actual)	Interventional	2012-07-31	Completed
Aspirin Impact on Platelet Reactivity in Acute Coronary Syndrome Patients on Novel P2Y12 Inhibitors Therapy[NCT02049762]	Phase 4	29 participants (Actual)	Interventional	2015-06-30	Completed
Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.[NCT00594867]	Phase 4	94 participants (Actual)	Interventional	2006-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months

Number of Participants With Ulcer Recurrence

Intervention	participants (Number)
Histamine-2 Receptor Antagonist Group	106
Placebo Group	101

Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month

Article	Year
Management of Peptic Ulcer Bleeding in Patients Taking Aspirin or Anticoagulant. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2020, 11-25, Volume: 76, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Duodenal Ulcer; Helicobacter Infec	2020
Helicobacter pylori infection and the risk of upper gastrointestinal bleeding in low dose aspirin users: systematic review and meta-analysis. The Medical journal of Australia, 2018, Sep-01, Volume: 209, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Helicobacter Infections; Helicobacter pylori; Humans; Middl	2018
[Gastrointestinal bleeding in the elderly]. Zentralblatt fur Chirurgie, 2014, Volume: 139, Issue:4 Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diagnosis, D	2014
Proton pump inhibitors in prevention of low-dose aspirin-associated upper gastrointestinal injuries. World journal of gastroenterology, 2015, May-07, Volume: 21, Issue:17 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Square Distribution; Cytoprotection; Humans; O	2015
[Risk of gastrointestinal bleeding with aspirin and platelet antiaggregants]. Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal	2009
Significant gastrointestinal bleeding in patients at risk of coronary stent thrombosis. Reviews in cardiovascular medicine, 2009,Winter, Volume: 10, Issue:1 Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anti-Bacterial Agents; Aspirin; Clopidogrel; Coro	2009
Predicting poor outcome from acute upper gastrointestinal hemorrhage. Gastroenterology clinics of North America, 2009, Volume: 38, Issue:2 Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endoscopy, Gastrointestinal; Esophageal and	2009
Management of patients with high gastrointestinal risk on antiplatelet therapy. Gastroenterology clinics of North America, 2009, Volume: 38, Issue:2 Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pi	2009
Optimal management of peptic ulcer disease in the elderly. Drugs & aging, 2010, Jul-01, Volume: 27, Issue:7 Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; He	2010
[Dilemma between gastroprotection and cardiovascular prevention]. Deutsche medizinische Wochenschrift (1946), 2010, Volume: 135, Issue:44 Topics: Alleles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases;	2010
[Influence of H. pylori infection on upper gastrointestinal damage]. Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68, Issue:11 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Helicobacter pylor	2010
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis]. Kardiologiia, 2010, Volume: 50, Issue:10 Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinica	2010
Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries: a comprehensive review. Journal of gastroenterology and hepatology, 2012, Volume: 27 Suppl 3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Duodena	2012
Population impact of strategies designed to reduce peptic ulcer risks associated with NSAID use. International journal of clinical practice. Supplement, 2003, Issue:135 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Incidence; Peptic Ulcer Hemorrhage; Risk F	2003
[Secondary and primary prophylaxis of gastropathy associated with nonsteroidal antiinflammatory drugs or low-dose-aspirin: a review based on four clinical scenarios]. Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:8 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gastrointestinal	2003
Review article: should NSAID/low-dose aspirin takers be tested routinely for H. pylori infection and treated if positive? Implications for primary risk of ulcer and ulcer relapse after initial healing. Alimentary pharmacology & therapeutics, 2004, Volume: 19 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Helicobacter pylori; Huma	2004
Gastrointestinal injury from NSAID therapy. How to reduce the risk of complications. Postgraduate medicine, 2005, Volume: 117, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Dyspepsia; Gastrointest	2005
Nonsteroidal anti-inflammatory drugs, aspirin, and gastrointestinal prophylaxis: an ounce of prevention. Reviews in gastroenterological disorders, 2005, Volume: 5 Suppl 2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pro	2005
Review article: from gastrin to gastro-oesophageal reflux disease--a century of acid suppression. Alimentary pharmacology & therapeutics, 2006, Mar-15, Volume: 23, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endoscopy, Gastrointestinal; Gastrins; Gastroesoph	2006
Review article: aspirin and gastrointestinal bleeding. Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:2 Topics: Anemia, Hypochromic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gast	1994
[Aspirin and the gastric mucosa--a new look at an old problem]. Harefuah, 1993, May-02, Volume: 124, Issue:9 Topics: Animals; Aspirin; Gastric Mucosa; Humans; Peptic Ulcer Hemorrhage; Stomach Diseases; Stomach Ulcer	1993
Management of nonsteroidal anti-inflammatory drug-related peptic ulcer bleeding. The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Butanone	2001
Progress report. Aspirin in chronic gastric ulcer: an Australian experience. Gut, 1976, Volume: 17, Issue:5 Topics: Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Self	1976
[Prostaglandins and damage to the gastric mucosa]. Orvosi hetilap, 1991, Jul-07, Volume: 132, Issue:27 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Histamine H2 Antagonists; Humans;	1991
The role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhage. The American journal of digestive diseases, 1973, Volume: 18, Issue:3 Topics: Animals; Ascorbic Acid; Aspirin; Blood Coagulation Disorders; Buffers; Dogs; Dosage Forms; Drug Syne	1973
Gastrointestinal hemorrhage. I. General considerations of diagnosis and the rapy. Advances in surgery, 1973, Volume: 7 Topics: Anus Diseases; Aspirin; Biliary Tract Diseases; Blood Coagulation Disorders; Burns; Child; Child, Pr	1973

Article	Year
Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. Lancet (London, England), 2022, 11-05, Volume: 400, Issue:10363 Topics: Aged; Anti-Bacterial Agents; Aspirin; Clarithromycin; Drug Therapy, Combination; Helicobacter; Helic	2022
In older patients receiving aspirin, Annals of internal medicine, 2023, Volume: 176, Issue:4 Topics: Aged; Aspirin; Helicobacter Infections; Helicobacter pylori; Hospitalization; Humans; Peptic Ulcer;	2023
Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet (London, England), 2017, Jun-17, Volume: 389, Issue:10087 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular	2017
Misoprostol for small bowel ulcers in patients with obscure bleeding taking aspirin and non-steroidal anti-inflammatory drugs (MASTERS): a randomised, double-blind, placebo-controlled, phase 3 trial. The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:7 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Double	2018
Misoprostol Heals Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding. Gastroenterology, 2018, Volume: 155, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biomar	2018
Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin. Gastroenterology, 2017, Volume: 152, Issue:1 Topics: Aged; Aged, 80 and over; Aspirin; Double-Blind Method; Famotidine; Female; Hemoglobins; Histamine H2	2017
Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. Alimentary pharmacology & therapeutics, 2011, Volume: 34, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopid	2011
Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. Alimentary pharmacology & therapeutics, 2004, Feb-01, Volume: 19, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Female; Humans;	2004
Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. Clinical therapeutics, 2004, Volume: 26, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, N	2004
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Th	2005
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:7 Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Metho	2006
Helicobacter pylori-positive peptic ulcer patients do not adapt to aspirin. Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:9 Topics: Adaptation, Physiological; Adult; Aspirin; Cell Division; DNA; Female; Gastric Mucosa; Gastroscopy;	1998
Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. The New England journal of medicine, 2002, Jun-27, Volume: 346, Issue:26 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A	2002
Mucosal cytoprotection by prostaglandin E2. Lancet (London, England), 1978, Dec-09, Volume: 2, Issue:8102 Topics: Administration, Oral; Adult; Aspirin; Clinical Trials as Topic; Drug Antagonism; Gastric Mucosa; Hor	1978
Diflunisal, aspirin, and gastric mucosa. Lancet (London, England), 1979, Sep-22, Volume: 2, Issue:8143 Topics: Aspirin; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Gastric Mucosa; Gastritis; Human	1979
Ranitidine: differential effects on gastric bleeding and mucosal damage induced by aspirin. Alimentary pharmacology & therapeutics, 1992, Volume: 6, Issue:6 Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastric Mucosa; Gastr	1992
Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study. Gut, 1991, Volume: 32, Issue:7 Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control	1991
The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. Journal of clinical gastroenterology, 1990, Volume: 12, Issue:3 Topics: Adult; Aged; Aspirin; Double-Blind Method; Duodenal Ulcer; Female; Follow-Up Studies; Hospitalizatio	1990

Article	Year
Aspirin and Helicobacter pylori interaction. Lancet (London, England), 2022, 11-05, Volume: 400, Issue:10363 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Helicobacter pylori; Huma	2022
Impact of Helicobacter pylori Eradication on Incidence of Peptic Ulcer Bleeding in Patients Taking Regular Aspirin. Gastroenterology, 2023, Volume: 164, Issue:6 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Helicoba	2023
Impact of Helicobacter pylori Eradication on Incidence of Peptic Ulcer Bleeding in Patients Taking Regular Aspirin. Gastroenterology, 2023, Volume: 164, Issue:6 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Helicoba	2023
Impact of Helicobacter pylori Eradication on Incidence of Peptic Ulcer Bleeding in Patients Taking Regular Aspirin. Gastroenterology, 2023, Volume: 164, Issue:6 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Helicoba	2023
Impact of Helicobacter pylori Eradication on Incidence of Peptic Ulcer Bleeding in Patients Taking Regular Aspirin. Gastroenterology, 2023, Volume: 164, Issue:6 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Helicoba	2023
Mortality and risk factors associated with peptic ulcer bleeding among adult inpatients of Damascus Hospital, Syria: A cross-sectional study. Medicine, 2023, Apr-25, Volume: 102, Issue:17 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Sectional Studies; Hospitals; H	2023
[Recent aspects of pharmaceutical and endoscopic treatment of acute gastroduodenal ulcer bleeding]. Orvosi hetilap, 2023, Jun-11, Volume: 164, Issue:23 Topics: Aspirin; Endoscopy, Gastrointestinal; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pharmaceutical	2023
Risks of adverse events for users of proton-pump inhibitors plus aspirin or clopidogrel in patients with aspirin-related ulcer bleeding. Journal of gastroenterology and hepatology, 2021, Volume: 36, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Databases, Factual; F	2021
Proton pump inhibitor use among patients at risk of peptic ulcer bleeding: a nationwide register-based study. Scandinavian journal of gastroenterology, 2021, Volume: 56, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pro	2021
The risk of lower gastrointestinal bleeding in low-dose aspirin users. Alimentary pharmacology & therapeutics, 2017, Volume: 45, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studi	2017
Continuing use of antithrombotic medications for patients with bleeding gastroduodenal ulcer requiring endoscopic hemostasis: a case-control study. Scandinavian journal of gastroenterology, 2017, Volume: 52, Issue:9 Topics: Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Duodenal Ulcer; Duodenum; Female; Fibrinolyt	2017
Cardiovascular events associated with proton pump inhibitors. JPMA. The Journal of the Pakistan Medical Association, 2017, Volume: 67, Issue:9 Topics: Aspirin; Cardiovascular Diseases; Coronary Artery Disease; Heart Failure; Humans; Mortality; Myocard	2017
Stopping antithrombotic therapy after acute upper gastrointestinal bleeding is associated with reduced survival. Postgraduate medical journal, 2018, Volume: 94, Issue:1109 Topics: Aged; Aspirin; Female; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male;	2018
Etiology and long-term rebleeding of endoscopic ulcerative lesions in the small bowel in patients with obscure gastrointestinal bleeding: A multicenter cohort study. Journal of gastroenterology and hepatology, 2018, Volume: 33, Issue:7 Topics: Aged; Aspirin; Capsule Endoscopy; Cohort Studies; Endoscopy, Gastrointestinal; Female; Follow-Up Stu	2018
Gastroduodenal ulcer bleeding in elderly patients on low dose aspirin therapy. World journal of gastroenterology, 2018, Sep-14, Volume: 24, Issue:34 Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebrovascu	2018
Low dose aspirin, H. pylori infection, and the risk of upper gastrointestinal bleeding. The Medical journal of Australia, 2018, 09-01, Volume: 209, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Helicobacter pylori; Huma	2018
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs. Current pharmaceutical design, 2014, Volume: 20, Issue:7 Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine	2014
[HP eradication prevents recurrent hemorrhages caused by acetylsalicylic acid]. MMW Fortschritte der Medizin, 2013, Jun-27, Volume: 155, Issue:12 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cohort Studies; Drug Therapy, C	2013
Risk factors of gastrointestinal bleeding in clopidogrel users: a nationwide population-based study. Alimentary pharmacology & therapeutics, 2013, Volume: 38, Issue:9 Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cohort Studies; Da	2013
Low-dose aspirin and comorbidities are significantly related to bleeding peptic ulcers in elderly patients compared with nonelderly patients in Japan. Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:5 Topics: Adolescent; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents,	2014
Opposing effects of aspirin and anticoagulants on morbidity and mortality in patients with upper gastrointestinal bleeding. Journal of digestive diseases, 2014, Volume: 15, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Female; H	2014
Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs. Vojnosanitetski pregled, 2014, Volume: 71, Issue:2 Topics: Aspirin; Blood Platelet Disorders; Female; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hem	2014
Patient characteristics among users of analgesic over-the-counter aspirin in a Danish pharmacy setting. International journal of clinical pharmacy, 2014, Volume: 36, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Aspirin; Denmark; Female; Heal	2014
Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding. World journal of gastroenterology, 2014, Sep-28, Volume: 20, Issue:36 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Capsule Endoscopy; Case-C	2014
Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study. Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Antihyper	2015
National consensus on management of peptic ulcer bleeding in Denmark 2014. Danish medical journal, 2014, Volume: 61, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Transfusion; Consensus; Denmark; Drug Therap	2014
Single nucleotide polymorphism markers for low-dose aspirin-associated peptic ulcer and ulcer bleeding. Journal of gastroenterology and hepatology, 2014, Volume: 29 Suppl 4 Topics: Adult; Aged; Aged, 80 and over; Alleles; Aspirin; Carbohydrate Sulfotransferases; Female; Genetic Pr	2014
Peptic Ulcer Bleeding Risk. The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users. The American journal of gastroenterology, 2015, Volume: 110, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Female; Helicob	2015
Clinical outcomes of nonvariceal upper gastrointestinal bleeding in Kosova. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25 Suppl 1 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An	2014
Endoscopic application of polysaccharide powder for hemostasis in anticoagulated pigs (with video). Gastrointestinal endoscopy, 2015, Volume: 82, Issue:1 Topics: Animals; Anticoagulants; Aspirin; Hemostasis, Endoscopic; Hemostatics; Heparin; Peptic Ulcer Hemorrh	2015
Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. Alimentary pharmacology & therapeutics, 2015, Volume: 42, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Cross-Over Stud	2015
Clinical characteristics of Helicobacter pylori-negative drug-negative peptic ulcer bleeding. World journal of gastroenterology, 2015, Jul-28, Volume: 21, Issue:28 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Breath Tests; Endoscopy, Gast	2015
[Comparison between Endoscopic Therapy and Medical Therapy in Peptic Ulcer Patients with Adherent Clot: A Multicenter Prospective Observational Cohort Study]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2015, Volume: 66, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Female; H	2015
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Digestive diseases and sciences, 2016, Volume: 61, Issue:9 Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont	2016
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Digestive diseases and sciences, 2016, Volume: 61, Issue:9 Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont	2016
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Digestive diseases and sciences, 2016, Volume: 61, Issue:9 Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont	2016
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. Digestive diseases and sciences, 2016, Volume: 61, Issue:9 Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont	2016
Risk factors influencing the outcome of peptic ulcer bleeding in chronic kidney disease after initial endoscopic hemostasis: A nationwide cohort study. Medicine, 2016, Volume: 95, Issue:36 Topics: Adult; Age Factors; Aged; Aspirin; Female; Hemostasis, Endoscopic; Hospital Costs; Humans; Intubatio	2016
Advances in gastrointestinal bleeding. Gastroenterologia y hepatologia, 2016, Volume: 39 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer;	2016
[Bleeding peptic ulcer. Prevalence of Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs/acetylsalicylic acid]. Ugeskrift for laeger, 2009, Jan-19, Volume: 171, Issue:4 Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Femal	2009
Guidelines for prevention of NSAID-related ulcer complications. The American journal of gastroenterology, 2009, Volume: 104, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Cyclooxygenase	2009
Clopidogrel. Patients with peptic ulcers. BMJ (Clinical research ed.), 2009, May-20, Volume: 338 Topics: Aspirin; Clopidogrel; Histamine H2 Antagonists; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregatio	2009
Upper gastrointestinal hemorrhage: have new therapeutics made a difference? Journal of hospital medicine, 2009, Volume: 4, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Square Distribution; Cyclooxygenase 2 Inhibito	2009
Low-dose aspirin reduces gastro-protective properties of COX-2 selective inhibitors. Clinical drug investigation, 2009, Volume: 29 Suppl 2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;	2009
New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1 Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;	2010
Mortality from peptic ulcer bleeding: the impact of comorbidity and the use of drugs that promote bleeding. Alimentary pharmacology & therapeutics, 2010, Volume: 32, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Comorbidity; Hospital Mortality; H	2010
Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin: renin angiotensin system genes' polymorphism. Digestive diseases and sciences, 2011, Volume: 56, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Case-Control Studies; Dose-Response Relationshi	2011
Interactive medical case. Bitter pills. The New England journal of medicine, 2010, Oct-14, Volume: 363, Issue:16 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biopsy; Creatini	2010
Clinical problem-solving. Bitter pills. The New England journal of medicine, 2010, Nov-04, Volume: 363, Issue:19 Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Diagnosis, Di	2010
Should prophylactic low-dose aspirin therapy be continued in peptic ulcer bleeding? Drugs, 2011, Jan-01, Volume: 71, Issue:1 Topics: Aspirin; Cardiovascular Diseases; Endoscopy, Gastrointestinal; Humans; Omeprazole; Peptic Ulcer Hemo	2011
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2011, Volume: 11, Issue:1 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ather	2011
[A survey of nonsteroidal anti-inflammatory drugs and aspirin associated peptic ulcer bleeding in hospitals]. Zhonghua nei ke za zhi, 2011, Volume: 50, Issue:2 Topics: Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Inp	2011
Anti-platelet therapy and managing ulcer risk. Journal of gastroenterology and hepatology, 2012, Volume: 27, Issue:2 Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Combined Modali	2012
Management of acute upper gastrointestinal bleeding: summary of NICE guidance. BMJ (Clinical research ed.), 2012, Jun-13, Volume: 344 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspir	2012
Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users. Gastroenterology, 2013, Volume: 144, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Fibrinolytic Agents; Helicobacter In	2013
Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2002, Volume: 54, Issue:3 Topics: Animals; Aspirin; Carbohydrates; Ethanol; Female; Fructose; Glucose; Honey; Indomethacin; Male; Malt	2002
[When the cardiac patient with arthritis needs aspirin and NSAID: how to protect the stomach?]. MMW Fortschritte der Medizin, 2003, Jan-30, Volume: 145, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Celecoxi	2003
[In high risk patients cyclooxygenase inhibitor plus proton pump inhibitor]. MMW Fortschritte der Medizin, 2003, Jan-30, Volume: 145, Issue:5 Topics: Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Coronary Disease; Cyclooxygenase 2; Cyclooxygenas	2003
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs]. Terapevticheskii arkhiv, 2003, Volume: 75, Issue:5 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno	2003
[Severe ulcerous hemorrhage after aspirin injection in a pregnant woman]. Archives des maladies de l'appareil digestif et des maladies de la nutrition, 1957, Volume: 46, Issue:11 Topics: Aspirin; Female; Hemorrhage; Humans; Injections; Peptic Ulcer; Peptic Ulcer Hemorrhage; Pregnancy; P	1957
[Digestive hemorrhages & gastroduodenal ulcers caused by aspirin; concerning 52 cases]. La Presse medicale, 1958, Dec-10, Volume: 66, Issue:87 Topics: Aspirin; Gastrointestinal Hemorrhage; Gastrointestinal Tract; Hemorrhage; Humans; Peptic Ulcer; Pept	1958
[Digestive hemorrhages triggered by aspirin in the course of ulcerous or undetermined syndromes. (Apropos of 10 cases)]. Archives des maladies de l'appareil digestif et des maladies de la nutrition, 1960, Volume: 49 Topics: Aspirin; Digestion; Hemorrhage; Humans; Peptic Ulcer Hemorrhage; Precipitating Factors; Syndrome	1960
Aspirin, gastrointestinal bleeding, and peptic ulcer. The American journal of digestive diseases, 1960, Volume: 5 Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage	1960
Aspirin and chronic gastric ulcer. The Medical journal of Australia, 1961, Dec-02, Volume: 48(2) Topics: Aspirin; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Stomach Ulcer	1961
THE MANAGEMENT OF GASTROINTESTINAL HEMORRHAGE. Medical science, 1963, Volume: 14 Topics: Aspirin; Diagnosis; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Peptic Ulcer Hemorrhage; Steroi	1963
[ACUTE DIGESTIVE HEMORRHAGES]. El Dia medico, 1963, Sep-19, Volume: 35 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticoagulants; Aspirin; Gastrointestinal Hemo	1963
ANAEMIA ASSOCIATED WITH UNEXPLAINED OCCULT BLOOD LOSS. British medical journal, 1964, May-30, Volume: 1, Issue:5395 Topics: Anemia; Anemia, Hypochromic; Aspirin; Diagnosis, Differential; Guaiac; Hemorrhoids; Humans; Iron; Li	1964
[EXPERIMENTAL STUDY OF GASTRIC TOLERANCE TO CORTICOID-ASPIRIN COMBINATIONS]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1963, Volume: 157 Topics: Adrenal Cortex Hormones; Aspirin; Betamethasone; Dermatologic Agents; Dexamethasone; Methylprednisol	1963
CAUSAL INFLUENCES IN HAEMATEMESIS AND MELAENA. Gut, 1965, Volume: 6 Topics: Alcoholic Beverages; Arteriosclerosis; Aspirin; Blood Group Antigens; Duodenal Ulcer; Genetics, Medi	1965
Aspirin and gastric bleeding: further studies of calcium aspirin. The American journal of digestive diseases, 1961, Volume: 6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium; Gastrointestinal Hemorrhage; Humans; Pept	1961
Upper gastrointestinal haemorrhage following cardiac surgery: a comparative study with vascular surgery patients from a single centre. European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:2 Topics: Aged; Aspirin; Cardiac Surgical Procedures; Coronary Artery Bypass; Duodenal Ulcer; Female; Gastroin	2004
Helicobacter pylori infection and the risk of gastro-duodenal damage in symptomatic elderly chronic low-dose aspirin users: effect of antisecretory drugs. Age and ageing, 2004, Volume: 33, Issue:4 Topics: Aged; Aspirin; Gastric Acid; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists;	2004
Reducing the risks of gastrointestinal bleeding with antiplatelet therapies. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopid	2005
Helicobacter pylori and nonsteroidal anti-inflammatory drugs in perforations and bleeding of peptic ulcers. Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breath Tests; Case-Control Studies; D	2005
The appropriate use of proton-pump inhibitor co-therapy with non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors. Alimentary pharmacology & therapeutics, 2005, Volume: 21 Suppl 1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraindications; Cyclooxygenase Inhibitors; Drug	2005
[Gastrointestinal bleeding during low dose acetylsalicylic acid. Is Godamed-100 TAH an alternative to conventional ASS preparations?]. Deutsche medizinische Wochenschrift (1946), 2005, Apr-22, Volume: 130, Issue:16 Topics: Aspirin; Cardiovascular Diseases; Drug Combinations; Gastrointestinal Hemorrhage; Glycine; Humans; P	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding. The New England journal of medicine, 2005, Apr-21, Volume: 352, Issue:16 Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Gastroi	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding. The New England journal of medicine, 2005, Apr-21, Volume: 352, Issue:16 Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Cost Savings; Drug Therapy, Combination; Fees, Pharmaceutic	2005
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding. The New England journal of medicine, 2005, Apr-21, Volume: 352, Issue:16 Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Contraindications; Drug Therapy, Combination; Humans; Pepti	2005
Changes in characteristics and outcome of acute upper gastrointestinal haemorrhage: a comparison of epidemiology and practices between 1996 and 2000 in a multicentre French study. European journal of gastroenterology & hepatology, 2005, Volume: 17, Issue:6 Topics: Acute Disease; Adolescent; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; A	2005
[Aspirin and cardiovascular prevention: last minute information]. Revue medicale de Liege, 2005, Volume: 60, Issue:3 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Peptic Ulcer Hemorrhage;	2005
A clinical study of Japanese patients with ulcer induced by low-dose aspirin and other non-steroidal anti-inflammatory drugs. Alimentary pharmacology & therapeutics, 2005, Volume: 21 Suppl 2 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Endoscopy, Gastroi	2005
[ASS or clopidogrel plus esomeprazole after bleeding from an ulcer]. Der Internist, 2005, Volume: 46, Issue:12 Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Do	2005
[Antiplatelet drugs and gastrointestinal bleeding: numquam periclum sine periclo vincitur]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2005, Volume: 6, Issue:10 Topics: Age Factors; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A	2005
[Gastric protection and treatment with low-dose aspirin]. Medicina clinica, 2006, Feb-18, Volume: 126, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal;	2006
Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. Gut, 2006, Volume: 55, Issue:12 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants	2006
[Epidemiology of gastrointestinal bleeding in the elderly]. Praxis, 2006, May-10, Volume: 95, Issue:19 Topics: Age Factors; Aged; Aged, 80 and over; Angiodysplasia; Anti-Inflammatory Agents, Non-Steroidal; Aspir	2006
[Gastroenterology in family practice. Updates for your "stomach patient"]. MMW Fortschritte der Medizin, 2006, Jun-01, Volume: 148, Issue:22 Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Dyspepsia; Esophagitis, Peptic; Family Practice; Heartburn;	2006
Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study. BMJ (Clinical research ed.), 2006, Oct-07, Volume: 333, Issue:7571 Topics: Aged; Aspirin; Case-Control Studies; Drug Therapy, Combination; Female; Fibrinolytic Agents; Gastroi	2006
Thirty-day mortality after peptic ulcer bleeding in hospitalized patients receiving low-dose aspirin at time of admission. The American journal of geriatric pharmacotherapy, 2006, Volume: 4, Issue:3 Topics: Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Dose-Response Relationship, Drug; Female; Hu	2006
Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology, 2007, Volume: 132, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Case-Control St	2007
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. Pharmacological research, 2007, Volume: 55, Issue:5 Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani	2007
[Coronary heart disease patient does not tolerate acetylsalicylic acid. Can clopidogrel be prescribed?]. MMW Fortschritte der Medizin, 2007, Apr-05, Volume: 149, Issue:14 Topics: Aspirin; Clopidogrel; Contraindications; Coronary Disease; Drug Therapy, Combination; Humans; Peptic	2007
[Pathogen eradication prevents gastrointestinal complications]. MMW Fortschritte der Medizin, 2007, Oct-25, Volume: 149, Issue:43 Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspi	2007
Incidence of serious upper gastrointestinal bleeding in patients taking non-steroidal anti-inflammatory drugs in Japan. Acta medica Okayama, 2008, Volume: 62, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Du	2008
Use of physician education and computer alert to improve targeted use of gastroprotection among NSAID users. The American journal of gastroenterology, 2008, Volume: 103, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiology; Coronary Care Units; Female; Gas	2008
Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man. Gut, 1983, Volume: 24, Issue:2 Topics: Adult; Anti-Ulcer Agents; Aspirin; Dinoprostone; DNA; Furans; Gastric Mucosa; Histamine H2 Antagonis	1983
[Drug-induced hemorrhages of the gastrointestinal tract]. Zeitschrift fur arztliche Fortbildung, 1983, Volume: 77, Issue:12 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Ethacrynic Acid; Gastrit	1983
Thrombotic etiology of stress ulcers. 1. The effect of anticoagulant and antiplatelet aggregators in the development of stress ulcers in rats. The American surgeon, 1983, Volume: 49, Issue:8 Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Gastric Acidity Determination; Gastric Mucosa; Hepar	1983
The preventive effect of low-dose aspirin in the development of stress ulceration in rats. The American surgeon, 1983, Volume: 49, Issue:8 Topics: Animals; Aspirin; Gastric Acid; Gastric Mucosa; Male; Peptic Ulcer Hemorrhage; Platelet Aggregation;	1983
Haematemesis and melaena in the elderly. Age and ageing, 1984, Volume: 13, Issue:1 Topics: Aged; Alcohol Drinking; Anti-Inflammatory Agents; Aspirin; Esophagitis; Female; Gastritis; Hematemes	1984
Aspirin and the stomach. British medical journal (Clinical research ed.), 1981, Apr-04, Volume: 282, Issue:6270 Topics: Aspirin; Humans; Peptic Ulcer Hemorrhage; Stomach Ulcer	1981
Peptic ulcer disease in children. Aspirin induced. New York state journal of medicine, 1981, Volume: 81, Issue:7 Topics: Aspirin; Child, Preschool; Humans; Infant; Male; Peptic Ulcer Hemorrhage; Stomach Ulcer	1981
[Changes in the mucous barrier of the stomach due to some drugs (author's transl)]. Ceskoslovenska gastroenterologie a vyziva, 1981, Volume: 35, Issue:6 Topics: Aspirin; Gastric Acidity Determination; Gastric Mucosa; Humans; Male; Middle Aged; Peptic Ulcer Hemo	1981
Prophylactic aspirin and peptic ulcer bleeding. Patients warned of a bleed may be more vigilant. BMJ (Clinical research ed.), 1995, Jul-22, Volume: 311, Issue:6999 Topics: Aspirin; Humans; Patient Education as Topic; Peptic Ulcer Hemorrhage	1995
Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ (Clinical research ed.), 1995, Apr-01, Volume: 310, Issue:6983 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Case-Control Studies; Che	1995
Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ (Clinical research ed.), 1995, Apr-01, Volume: 310, Issue:6983 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Case-Control Studies; Che	1995
Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ (Clinical research ed.), 1995, Apr-01, Volume: 310, Issue:6983 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Case-Control Studies; Che	1995
Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ (Clinical research ed.), 1995, Apr-01, Volume: 310, Issue:6983 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Case-Control Studies; Che	1995
Relation of the use of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) to upper gastrointestinal bleeding: a preliminary report of a Finnish case-control prospective study. Pharmacology & toxicology, 1994, Volume: 75 Suppl 2 Topics: Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-C	1994
[The prophylactic taking of low doses of acetylsalicylic acid and the risk of ulcer hemorrhage]. Deutsche medizinische Wochenschrift (1946), 1995, Dec-15, Volume: 120, Issue:50 Topics: Aspirin; Dose-Response Relationship, Drug; Duodenal Ulcer; Humans; Middle Aged; Peptic Ulcer Hemorrh	1995
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. Journal of gastroenterology and hepatology, 1996, Volume: 11, Issue:10 Topics: Animals; Aspirin; Benzofurans; Ethanol; Female; Gastritis; Indomethacin; Iodoacetamide; Leukotriene	1996
Which peptic ulcers bleed? Results of a case-control study. DUSUK Study Group. Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:2 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Comorbidity; Endoscopy	1997
[NSAID and ulcer complications. An analysis of risk factors]. Ugeskrift for laeger, 1997, Jun-09, Volume: 159, Issue:24 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Databases, Factual; Female; Humans; M	1997
Peptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs. Gut, 1997, Volume: 41, Issue:4 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Female; Helicobacter I	1997
Nitrovasodilators, low-dose aspirin, other nonsteroidal antiinflammatory drugs, and the risk of upper gastrointestinal bleeding. The New England journal of medicine, 2000, Sep-21, Volume: 343, Issue:12 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Drug Interactions; Dru	2000
[The role of endogenous glucocorticoids in maintenance of the gastric mucosa integrity]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2000, Volume: 86, Issue:11 Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corticosterone; Gastric Mu	2000
Contraindicated NSAIDs are frequently prescribed to elderly patients with peptic ulcer disease. British journal of clinical pharmacology, 2002, Volume: 53, Issue:2 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Co	2002
[Long-term prophylaxis with omeprazol is superior to eradication therapy in H. pylori-positive NSAIDs taking patients]. Zeitschrift fur Gastroenterologie, 2002, Volume: 40, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Helicobacter Inf	2002
Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Bacterial; Aspirin; Bacterial Protei	2002
Aspirin injury and H pylori. Gut, 2002, Volume: 50, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gerbillinae; Helicobacter Infections; Hel	2002
Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils. Gut, 2002, Volume: 50, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotactic Factors; Gastric Mucosa; Gerb	2002
Upper gastrointestinal haemorrhage in hepatic cirrhosis: causes and relation to hepatic failure and stress. Lancet (London, England), 1977, Jan-29, Volume: 1, Issue:8005 Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aspirin; Chronic Disease; Esophagea	1977
Duodenogastric reflux of bile and aspirin-induced gastric damage in man. Lancet (London, England), 1977, Mar-12, Volume: 1, Issue:8011 Topics: Aspirin; Bile; Humans; Peptic Ulcer Hemorrhage; Stomach Ulcer	1977
Aspirin and renal function. Lancet (London, England), 1977, May-14, Volume: 1, Issue:8020 Topics: Aspirin; Humans; Kidney Failure, Chronic; Peptic Ulcer; Peptic Ulcer Hemorrhage	1977
[Clinical aspects and course of drug-induced upper digestive hemorrhage]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1976, Nov-23, Volume: 52, Issue:40 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoag	1976
[Gastrointestinal hemorrhage during treatment with ibuprofen (Brufen)]. Ugeskrift for laeger, 1977, Feb-14, Volume: 139, Issue:7 Topics: Aged; Aspirin; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Midd	1977
Acute upper-gastrointestinal hemorrhage. New observations on an old problem. The American journal of digestive diseases, 1978, Volume: 23, Issue:1 Topics: Alcohol Drinking; Aspirin; Duodenal Ulcer; Esophageal and Gastric Varices; Esophagoscopy; Gastritis;	1978
Aspirin and gastrointestional bleeding. Interest of plasma salicylate determination. Digestion, 1979, Volume: 19, Issue:3 Topics: Aspirin; Duodenal Diseases; Enteritis; Gastritis; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer	1979
Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scandinavian journal of gastroenterology, 1979, Volume: 14, Issue:5 Topics: Adult; Animals; Aspirin; Drug Evaluation, Preclinical; Gastric Mucosa; Glycyrrhiza; Humans; Male; Mi	1979
[Gastrointestinal hemorrhage caused by side effect of drugs]. Klinicheskaia meditsina, 1976, Volume: 54, Issue:10 Topics: Adult; Aged; Aspirin; Butadienes; Drug-Related Side Effects and Adverse Reactions; Female; Humans; I	1976
[Case of profuse gastrointestinal hemorrhage after long-term administration of aspirin]. Klinicheskaia meditsina, 1976, Volume: 54, Issue:10 Topics: Adult; Aspirin; Humans; Male; Peptic Ulcer Hemorrhage; Stomach Ulcer; Time Factors	1976
Upper gastrointestinal hemorrhage clinical, radiological and endoscopic correlation of 100 consecutive cases. Pahlavi medical journal, 1976, Volume: 7, Issue:4 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy; Esophageal Diseases; Ethanol; Female; Gastritis; Ga	1976
Results of emergency surgical management of hemorrhagic duodenal ulcer. Mayo Clinic proceedings, 1975, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aged; Aspirin; Duodenal Ulcer; Emergencies; Female; Gastrectomy; Gastroscopy; Hum	1975
Gastric changes in coronary-operated patients with low-dose aspirin. Scandinavian journal of gastroenterology, 1992, Volume: 27, Issue:11 Topics: Adult; Aged; Aspirin; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Fe	1992
Value of a centralised approach in the management of haematemesis and melaena: experience in a district general hospital. Gut, 1990, Volume: 31, Issue:5 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Femal	1990
[Frequency and severity of gastric and duodenal lesions induced by non-steroidal anti-inflammatory agents and aspirin]. Gastroenterologie clinique et biologique, 1989, Volume: 13, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; France; Humans; Male; Peptic Ulcer; Peptic	1989
Fatal peptic ulcer complications and the use of non-steroidal anti-inflammatory drugs, aspirin, and corticosteroids. British medical journal (Clinical research ed.), 1987, Nov-14, Volume: 295, Issue:6608 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A	1987
Aspirin and bleeding peptic ulcers in the elderly. BMJ (Clinical research ed.), 1988, Nov-19, Volume: 297, Issue:6659 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle	1988
Which peptic ulcer patients bleed? Gut, 1988, Volume: 29, Issue:1 Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Male; Mi	1988
[Pharmacological studies on the effects of some traditional Chinese medicines on gastric functions. (3) The effects of oren-gedoku-to (OGT), san'o-syasin-to (SST), antyu-san (AS) and dai-saiko-to (DST) on ethanol- and aspirin-induced gastric lesions in ra Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1988, Volume: 91, Issue:5 Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; Male; Peptic Ulc	1988
Protective effects of the prostaglandins on the gastric mucosa. The American journal of medicine, 1986, Aug-18, Volume: 81, Issue:2A Topics: Animals; Aspirin; Cricetinae; Dinoprostone; Gastric Acid; Gastric Mucosa; Humans; Intestinal Mucosa;	1986
[Chronic upper abdominal pain with iron-deficiency anemia and analgesic-induced hemorrhaging stomach ulcers: duodenal wall carcinoid without flush symptoms]. Medizinische Klinik (Munich, Germany : 1983), 1987, Sep-18, Volume: 82, Issue:19 Topics: Adult; Anemia, Hypochromic; Aspirin; Carcinoid Tumor; Duodenal Neoplasms; Duodenum; Humans; Male; Mi	1987
Prostaglandins and cellular restitution in the gastric mucosa. The American journal of medicine, 1986, Aug-18, Volume: 81, Issue:2A Topics: Animals; Aspirin; Cell Movement; Ethanol; Gastric Mucosa; Microcirculation; Microscopy, Electron, Sc	1986
Ascorbic-acid levels in leucocytes of patients with gastrointestinal haemorrhage. Lancet (London, England), 1968, Sep-14, Volume: 2, Issue:7568 Topics: Adult; Alcoholic Intoxication; Ascorbic Acid; Ascorbic Acid Deficiency; Aspirin; Blood Cell Count; C	1968
[The fate of 165 hemorrhagic ulcers treated in a special intensive care unit]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1973, Feb-14, Volume: 49, Issue:8 Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Emergencies; Esoph	1973
The natural history of duodenal ulceration. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Apr-08, Volume: 46, Issue:15 Topics: Aspirin; Duodenal Ulcer; Female; Gastric Acidity Determination; Gastric Juice; Gastrointestinal Hemo	1972
[Nosologic borderlines of gastroduodenal ulcerous disease]. Archives francaises des maladies de l'appareil digestif, 1972, Volume: 61, Issue:3 Topics: Aspirin; Diagnosis, Differential; Gastritis; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Pept	1972
Acute gastro-intestinal haemorrhage. Prognostic factors on a conservative regime. The Medical journal of Australia, 1972, Jul-22, Volume: 2, Issue:4 Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Child; Child, Preschool; Du	1972
The management of upper gastro-intestinal tract haemorrhage. The British journal of surgery, 1973, Volume: 60, Issue:4 Topics: Adolescent; Adult; Aged; Aortic Aneurysm; Aspirin; Carcinoma; Duodenal Ulcer; Esophageal and Gastric	1973
Epidemiology and course of gastrointestinal haemorrhage in North-east Scotland. British medical journal, 1973, Sep-29, Volume: 3, Issue:5882 Topics: Adult; Aged; Alcohol Drinking; Aspirin; Blood Group Antigens; Duodenal Ulcer; Female; Gastritis; Gas	1973
Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. The New England journal of medicine, 1974, May-23, Volume: 290, Issue:21 Topics: Adult; Aged; Aspirin; Boston; Drug Evaluation; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage;	1974
The management of a patient with a duodenal ulcer. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Nov-25, Volume: 46, Issue:47 Topics: Adult; Alcohol Drinking; Alkalies; Aspirin; Chronic Disease; Diet Therapy; Duodenal Ulcer; Humans; P	1972
[Peptic ulcer hemorrhage due to anticoagulants]. Deutsche medizinische Wochenschrift (1946), 1973, Sep-14, Volume: 98, Issue:37 Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Blood Transfusion; Coumarins; Digitalis Glycosides; Do	1973
Aspirin gastritis or acute peptic ulceration? The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1971, Volume: 123, Issue:11 Topics: Acute Disease; Adolescent; Aspirin; Diagnosis, Differential; Female; Gastritis; Humans; Peptic Ulcer	1971
Lesions associated with gastroduodenal haemorrhage, in relation to aspirin intake. British medical journal, 1968, Dec-14, Volume: 4, Issue:5632 Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans;	1968
[Upper digestive hemorrhages in patients with gastroduodenal ulcer after administration of ulcerogenic drugs]. Medicina interna, 1969, Mar-03, Volume: 21, Issue:3 Topics: Adult; Aged; Aminopyrine; Aspirin; Duodenal Ulcer; Female; Humans; Hydrocortisone; Influenza, Human;	1969
Gastro-intestinal bleeding: the role of vitamin C. Australasian annals of medicine, 1969, Volume: 18, Issue:3 Topics: Ascorbic Acid Deficiency; Aspirin; Feeding Behavior; Gastrointestinal Hemorrhage; Hernia, Diaphragma	1969
Gastrointestinal haemorrhage, gastric ulcer and aspirin. Australasian annals of medicine, 1970, Volume: 19, Issue:2 Topics: Acute Disease; Adult; Age Factors; Aged; Aspirin; Australia; Diagnosis, Differential; Female; Gastro	1970
[Apropos of 135 cases of massive gastroduodenal hemorrhage (portal hypertension excluded)]. Annales de chirurgie, 1968, Volume: 22, Issue:5 Topics: Adult; Aged; Anticoagulants; Aspirin; Cortisone; Endoscopy; Female; Gastritis; Gastrointestinal Hemo	1968
Comparison of gastric toxicity of acetylsalicylic acid with route of administration in the rat. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 190, Issue:1 Topics: Animals; Aspirin; Disease Models, Animal; Gastric Acidity Determination; Gastric Juice; Gastric Muco	1971
Mortality following emergency partial gastrectomy for gastro-duodenal haemorrhage. Singapore medical journal, 1971, Volume: 12, Issue:3 Topics: Age Factors; Aged; Aspirin; Blood Transfusion; Emergencies; Female; Gastrectomy; Gastrointestinal He	1971
Aspirin and alcohol in gastrointestinal haemorrhage. Gut, 1971, Volume: 12, Issue:10 Topics: Aspirin; Drug Synergism; Duodenal Ulcer; Esophageal and Gastric Varices; Ethanol; Female; Gastritis;	1971
Gastric mucosal blood flow following damage by ethanol, acetic acid, or aspirin. Gastroenterology, 1970, Volume: 58, Issue:3 Topics: Acetates; Aminopyrine; Animals; Aspirin; Dogs; Ethanol; Gastric Lavage; Gastric Mucosa; Peptic Ulcer	1970
[Aspirin, butazolidin and corticoids in hemorrhagic ulcers]. Revista espanola de las enfermedades del aparato digestivo, 1970, Feb-15, Volume: 30, Issue:4 Topics: Adrenal Cortex Hormones; Aspirin; Peptic Ulcer Hemorrhage; Phenylbutazone	1970
[Hemorrhage in gastroduodenal ulcer]. Revista clinica espanola, 1967, Oct-31, Volume: 107, Issue:2 Topics: Adult; Aged; Aspirin; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage	1967
[Gastric hemorrhage technics in rabbits using aspirin, reserpine and both substances in combination]. Archives francaises des maladies de l'appareil digestif, 1966, Volume: 55, Issue:5 Topics: Animals; Aspirin; Peptic Ulcer Hemorrhage; Rabbits; Reserpine	1966

Intervention	participants (Number)
Proton Pump Inhibitor Group	1
Histamine-2 Receptor Antagonist Group	7

aspirin and Hemorrhage, Peptic Ulcer