Page last updated: 2024-10-23

aspirin and Hematoma, Subdural

aspirin has been researched along with Hematoma, Subdural in 37 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Hematoma, Subdural: Accumulation of blood in the SUBDURAL SPACE between the DURA MATER and the arachnoidal layer of the MENINGES. This condition primarily occurs over the surface of a CEREBRAL HEMISPHERE, but may develop in the spinal canal (HEMATOMA, SUBDURAL, SPINAL). Subdural hematoma can be classified as the acute or the chronic form, with immediate or delayed symptom onset, respectively. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS)."7.73The risks and safety of clopidogrel in pediatric arterial ischemic stroke. ( Allen, A; deVeber, G; Hune, S; MacGregor, D; Rafay, MF; Soman, T, 2006)
"A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented."7.69Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report. ( Ashkenazi, E; Israel, Z; Spektor, S, 1995)
"Clopidogrel combined with aspirin is routinely prescribed after coronary artery stenting, in patients with acute coronary syndromes, and recently to prevent stroke in patients with acute minor ischemic stroke and TIA."4.91Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials. ( Bakheet, MF; Hart, RG; Pearce, LA, 2015)
"We sought to characterize the risk of subdural hematoma associated with antiplatelet therapy."3.87Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials. ( Connolly, BJ; Hart, RG; Kase, CS; Kurth, T; Pearce, LA, 2013)
"The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS)."3.73The risks and safety of clopidogrel in pediatric arterial ischemic stroke. ( Allen, A; deVeber, G; Hune, S; MacGregor, D; Rafay, MF; Soman, T, 2006)
"A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented."3.69Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report. ( Ashkenazi, E; Israel, Z; Spektor, S, 1995)
"Numbers of subdural hematoma were available from thirteen randomized trials involving 155,554 participants comparing aspirin (dosage range 25 mg twice daily to 325 mg daily) to placebo (ten double-blind trials) or no aspirin (three trials)."2.72Aspirin Use and Risk of Subdural Hematoma: Updated Meta-Analysis of Randomized Trials. ( Catanese, L; Connolly, BJ; Gorelick, PB; Hart, RG; Pearce, LA, 2021)
"Among those developing intracranial hemorrhage, limited data are available to guide clinicians with antithrombotic reinitiation."1.56Warfarin Reinitiation After Intracranial Hemorrhage: A Case Series of Heart Valve Patients. ( Bungard, TJ; Butcher, K; Hodgson, M; Schultz, K; Wan, A, 2020)
"Aspirin pretreatment prevented the diffuse thrombosis of cortical and subcortical vessels after aSDH."1.48Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model. ( Hsieh, ST; Huang, SJ; Lee, JE; Lin, WC; Po-Hao Huang, A; Tsai, JC; Wang, HC; Wang, KC, 2018)
" No duration of use or dose-response association was apparent."1.46Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice. ( Bromley, S; Cea Soriano, L; Gaist, D; García Rodríguez, LA; Soriano-Gabarró, M, 2017)
"Incidence of subdural hematoma has been reported to be increasing."1.46Association of Antithrombotic Drug Use With Subdural Hematoma Risk. ( Gaist, D; García Rodríguez, LA; Hallas, J; Halle, B; Hellfritzsch, M; Pottegård, A; Poulsen, FR, 2017)
"Severe bleeding was defined by the need for admission to hospital."1.31Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment. ( Castellino, G; Cuadrado, MJ; Godfrey, T; Hughes, GR; Khamashta, MA, 2001)
"A newborn had a subdural hematoma detected with a prenatal ultrasonography at 31 weeks' gestation, probably in keeping with the regular treatment of AAS."1.30[Favorable outcome of a subdural hematoma diagnosed in utero]. ( Daussac, E; Lafont, M; Lamarque, M, 1999)
"Chronic subdural hematoma appears to be a suitable model for the evaluation of risk factors in the development of hemorrhage."1.28Aspirin as a risk factor for hemorrhage in patients with head injuries. ( Gratzl, O; Marbet, G; Radü, EW; Reymond, MA, 1992)
"One died of subdural hematoma of non-operated side seven months after contralateral bypass procedure."1.26[Reconstructive operation of Moyamoya disease and its problems (author's transl)]. ( Abe, H; Gotoh, S; Kashiwaba, T; Miyasaka, K; Nakagawa, Y; Ohtsuka, K; Shimoyama, M; Suzuki, Y; Takei, H; Tsuru, M, 1981)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19905 (13.51)18.7374
1990's8 (21.62)18.2507
2000's8 (21.62)29.6817
2010's13 (35.14)24.3611
2020's3 (8.11)2.80

Authors

AuthorsStudies
Laic, RAG1
Verhamme, P1
Vander Sloten, J1
Depreitere, B1
Wan, A1
Butcher, K1
Hodgson, M1
Schultz, K1
Bungard, TJ1
Hart, RG3
Pearce, LA3
Gorelick, PB1
Connolly, BJ2
Catanese, L1
Cea Soriano, L2
Gaist, D3
Soriano-Gabarró, M2
García Rodríguez, LA3
Turgut, M1
Agrawal, M1
Borkar, SA1
Singla, R1
Mahapatra, AK1
Bromley, S1
Wang, HC1
Tsai, JC1
Lee, JE1
Huang, SJ1
Po-Hao Huang, A1
Lin, WC1
Hsieh, ST1
Wang, KC1
Pandya, U1
Malik, A1
Messina, M1
Albeiruti, AR1
Spalding, C1
Kurth, T1
Kase, CS1
Bakheet, MF1
Birkeland, P1
Lauritsen, J1
Poulsen, FR2
Zheng, F1
Hellfritzsch, M1
Halle, B1
Hallas, J1
Pottegård, A1
Krupa, M1
Moskała, M1
Składzień, T1
Grzywna, E1
Vuk, A1
Stancić, V1
Rincić, G1
Ledinsky, M1
Grbac, L1
Stancić, N1
Amin, AG1
Ng, J1
Hsu, W1
Pradilla, G1
Raza, S1
Quinones-Hinojosa, A1
Lim, M1
Soman, T1
Rafay, MF1
Hune, S1
Allen, A1
MacGregor, D1
deVeber, G1
McClaskey, EM1
Michalets, EL1
Pechlaner, C1
Marschang, P1
Fujii, H1
Kambe, N1
Fujisawa, A1
Kohno, K1
Morita, E1
Miyachi, Y1
Nakagawa, Y1
Shimoyama, M1
Kashiwaba, T1
Suzuki, Y1
Gotoh, S2
Miyasaka, K1
Takei, H1
Ohtsuka, K1
Abe, H1
Tsuru, M1
Spektor, S1
Ashkenazi, E1
Israel, Z1
Pryle, BJ1
Carter, JA1
Cadoux-Hudson, T1
Stroobandt, G1
Fransen, P1
Thauvoy, C1
Menard, E1
Schneider, MC1
Caliezi, C1
Seeberger, MD1
Wellman, M1
Martin, AC1
Lafont, M1
Lamarque, M1
Daussac, E1
Gubitz, G1
Sandercock, P1
O'Brien, DF1
Basu, S1
O'Donnell, JR1
Roberts, GA1
Phillips, J1
Castellino, G1
Cuadrado, MJ1
Godfrey, T1
Khamashta, MA1
Hughes, GR1
Reymond, MA1
Marbet, G1
Radü, EW1
Gratzl, O1
McDonald, CL1
Mahmood, NF1
Grant, KF1
Rosner, S1
Davis, JW1
Phillips, PE1
Ellison, JM1
Lucas, SR1
Bechar, M1
Lakke, JP1
van der Hem, GK1
Beks, JW1
Penning, L1
Vroom, FQ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pharmacoepidemiological Study on the Risk of Bleeding in New Users of Low-dose Aspirin (ASA) in The Health Improvement Network (THIN), UK[NCT02550717]398,158 participants (Actual)Observational2015-09-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for aspirin and Hematoma, Subdural

ArticleYear
Aspirin Use and Risk of Subdural Hematoma: Updated Meta-Analysis of Randomized Trials.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:8

    Topics: Aged; Aspirin; Female; Fibrinolytic Agents; Hematoma, Subdural; Humans; Male; Middle Aged; Randomize

2021
Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2013, Volume: 22, Issue:4

    Topics: Age Factors; Aged; Aspirin; Hematoma, Subdural; Humans; Odds Ratio; Platelet Aggregation Inhibitors;

2013
Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials.
    International journal of stroke : official journal of the International Stroke Society, 2015, Volume: 10, Issue:4

    Topics: Acute Coronary Syndrome; Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination;

2015
Acute ischaemic stroke.
    BMJ (Clinical research ed.), 2000, Mar-11, Volume: 320, Issue:7236

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Evidence-Based Medicine; Hematoma, Subdural; Human

2000

Trials

2 trials available for aspirin and Hematoma, Subdural

ArticleYear
Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2013, Volume: 22, Issue:4

    Topics: Age Factors; Aged; Aspirin; Hematoma, Subdural; Humans; Odds Ratio; Platelet Aggregation Inhibitors;

2013
Dabigatran versus enoxaparin after total hip replacement.
    Lancet (London, England), 2007, Dec-15, Volume: 370, Issue:9604

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Aspirin; Hematoma, Subdural

2007

Other Studies

32 other studies available for aspirin and Hematoma, Subdural

ArticleYear
Long-term outcomes after traumatic brain injury in elderly patients on antithrombotic therapy.
    Acta neurochirurgica, 2023, Volume: 165, Issue:5

    Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Brain Injuries, Traumatic; Fibrinolytic Agents; He

2023
Warfarin Reinitiation After Intracranial Hemorrhage: A Case Series of Heart Valve Patients.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020, Volume: 47, Issue:2

    Topics: Aged; Anticoagulants; Antifibrinolytic Agents; Aortic Valve; Aspirin; Blood Coagulation Factors; Cer

2020
Incidence of intracranial bleeds in new users of low-dose aspirin: a cohort study using The Health Improvement Network.
    Journal of thrombosis and haemostasis : JTH, 2017, Volume: 15, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cohort Studies; Female; Follow-Up Studies; Hematoma, Subdur

2017
Letter to the Editor Regarding "Burr-Hole Drainage for Chronic Subdural Hematoma Under Low-Dose Acetylsalicylic Acid: A Comparative Risk Analysis Study".
    World neurosurgery, 2017, Volume: 106

    Topics: Aspirin; Drainage; Hematoma, Subdural; Hematoma, Subdural, Chronic; Humans; Trephining

2017
Letter to the Editor Regarding "Burr-Hole Drainage for Chronic Subdural Hematoma under Low-Dose Acetylsalicylic Acid: a Comparative Risk Analysis Study".
    World neurosurgery, 2017, Volume: 107

    Topics: Aspirin; Drainage; Hematoma, Subdural; Hematoma, Subdural, Chronic; Humans; Trephining

2017
Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice.
    Neurology, 2017, Nov-28, Volume: 89, Issue:22

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Cohort Studies; Dose-Response Relation

2017
Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model.
    Journal of neurosurgery, 2018, Volume: 129, Issue:4

    Topics: Acute Disease; Animals; Aspirin; Blood Gas Monitoring, Transcutaneous; Blood-Brain Barrier; Brain; D

2018
Reversal of antiplatelet therapy in traumatic intracranial hemorrhage: Does timing matter?
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2018, Volume: 50

    Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Glasgow Coma Scale; Hematoma, Subdural; Humans; Intracran

2018
Aspirin is associated with an increased risk of subdural hematoma in normal-pressure hydrocephalus patients following shunt implantation.
    Journal of neurosurgery, 2015, Volume: 123, Issue:2

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebrospinal Fluid Shunts; Clopidogrel; Female; Fibrinolytic Agen

2015
Does clopidogrel plus aspirin really significantly increase the risk of subdural hematoma?
    International journal of stroke : official journal of the International Stroke Society, 2016, Volume: 11, Issue:6

    Topics: Aspirin; Clopidogrel; Hematoma, Subdural; Humans; Randomized Controlled Trials as Topic; Stroke

2016
Association of Antithrombotic Drug Use With Subdural Hematoma Risk.
    JAMA, 2017, Feb-28, Volume: 317, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Comorbid

2017
[Influence of anticoagulants on the appearance of chronic subdural hematoma].
    Przeglad lekarski, 2009, Volume: 66, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Cardiovascular Diseases; Chronic Disease; C

2009
Nontraumatic bilateral subdural hematoma caused by antiaggregation therapy: case report and review of the literature.
    Acta clinica Croatica, 2010, Volume: 49, Issue:2

    Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Female; Hematoma, Subdural; Humans; Middle Aged; Platel

2010
Postoperative anticoagulation in patients with mechanical heart valves following surgical treatment of subdural hematomas.
    Neurocritical care, 2013, Volume: 19, Issue:1

    Topics: Aged; Anticoagulants; Aspirin; Enoxaparin; Female; Follow-Up Studies; Heart Valve Prosthesis Implant

2013
The risks and safety of clopidogrel in pediatric arterial ischemic stroke.
    Stroke, 2006, Volume: 37, Issue:4

    Topics: Adolescent; Aspirin; Brain Ischemia; Child; Child, Preschool; Clopidogrel; Cohort Studies; Drug Ther

2006
Subdural hematoma after a fall in an elderly patient taking high-dose omega-3 fatty acids with warfarin and aspirin: case report and review of the literature.
    Pharmacotherapy, 2007, Volume: 27, Issue:1

    Topics: Accidental Falls; Aged; Anticoagulants; Aspirin; Drug Interactions; Fatty Acids, Omega-3; Hematoma,

2007
Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy.
    Allergology international : official journal of the Japanese Society of Allergology, 2008, Volume: 57, Issue:1

    Topics: Anaphylaxis; Aspirin; Exercise; Gliadin; Hematoma, Subdural; Humans; Immunoglobulin E; Male; Middle

2008
[Reconstructive operation of Moyamoya disease and its problems (author's transl)].
    No shinkei geka. Neurological surgery, 1981, Volume: 9, Issue:3

    Topics: Adult; Arterial Occlusive Diseases; Aspirin; Cerebral Angiography; Cerebral Revascularization; Child

1981
Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.
    Acta neurochirurgica, 1995, Volume: 134, Issue:1-2

    Topics: Aged; Aspirin; Craniotomy; Female; Hematoma, Subdural; Humans; Ischemic Attack, Transient; Meningeal

1995
Delayed paraplegia following spinal anaesthesia. Spinal subdural haematoma following dural puncture with a 25 G pencil point needle at T12-L1 in a patient taking aspirin.
    Anaesthesia, 1996, Volume: 51, Issue:3

    Topics: Aged; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Hematoma, Subdur

1996
Pathogenetic factors in chronic subdural haematoma and causes of recurrence after drainage.
    Acta neurochirurgica, 1995, Volume: 137, Issue:1-2

    Topics: Adult; Aged; Aspirin; Chronic Disease; Drainage; Female; Hematoma, Subdural; Humans; Male; Middle Ag

1995
Antiplatelet therapy or low-dose heparin and neuraxial anaesthesia.
    Acta anaesthesiologica Scandinavica. Supplementum, 1997, Volume: 111

    Topics: Anesthesia, Epidural; Anesthesia, Spinal; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; A

1997
Antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls.
    The Journal of family practice, 1999, Volume: 48, Issue:7

    Topics: Accidental Falls; Aged; Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Decision Support Te

1999
[Favorable outcome of a subdural hematoma diagnosed in utero].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:9

    Topics: Adult; Aspirin; Female; Fetal Growth Retardation; Follow-Up Studies; Hematoma, Subdural; Humans; Inf

1999
The impact of aspirin therapy and anticoagulation on the prevalence of spontaneous subdural haematoma.
    Irish medical journal, 2000, Volume: 93, Issue:8

    Topics: Adult; Aged; Anticoagulants; Aspirin; Female; Hematoma, Subdural; Humans; Male; Prevalence; Reoperat

2000
Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment.
    Annals of the rheumatic diseases, 2001, Volume: 60, Issue:5

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antiphospholipid Syndrome; Asp

2001
Aspirin as a risk factor for hemorrhage in patients with head injuries.
    Neurosurgical review, 1992, Volume: 15, Issue:1

    Topics: Adult; Aged; Aspirin; Brain Concussion; Cerebral Hemorrhage; Female; Hematoma, Epidural, Cranial; He

1992
Dysarthria and a numb hand in an elderly woman.
    Hospital practice (Office ed.), 1992, Jan-15, Volume: 27, Issue:1

    Topics: Aged; Aspirin; Cerebral Infarction; Dysarthria; Female; Hand; Hematoma, Subdural; Humans; Paresthesi

1992
The diagnosis and treatment of cerebral concussion.
    International surgery, 1967, Volume: 47, Issue:4

    Topics: Ascorbic Acid; Aspirin; Brain Concussion; Cerebral Ventriculography; Cortisone; Diphenhydramine; Ele

1967
Effect of aspirin on bleeding time and survival of rats after head trauma.
    Journal of medicine, 1974, Volume: 5, Issue:5

    Topics: Animals; Aspirin; Bicarbonates; Blood Coagulation; Blood Coagulation Tests; Buffers; Cerebral Hemorr

1974
Subdural hematoma during long-term hemodialysis.
    Archives of neurology, 1972, Volume: 26, Issue:6

    Topics: Acenocoumarol; Adolescent; Adult; Aspirin; Cerebral Angiography; Female; Hematoma, Subdural; Heparin

1972
Treatment of stroke: medical or surgical?
    Geriatrics, 1974, Volume: 29, Issue:3

    Topics: Angiography; Antihypertensive Agents; Aspirin; Blood Pressure; Carotid Arteries; Carotid Artery Thro

1974