aspirin has been researched along with Headache, Tension in 21 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to compare the efficacy and safety profiles of aspirin, acetaminophen with codeine, and placebo in the treatment of post-operative dental pain and tension-type headache." | 9.16 | Assessment of the efficacy and safety profiles of aspirin and acetaminophen with codeine: results from 2 randomized, controlled trials in individuals with tension-type headache and postoperative dental pain. ( Fisher, M; Gatoulis, SC; Voelker, M, 2012) |
| "To assess the efficacy and safety of aspirin for acute treatment of episodic tension-type headache (TTH) in adults compared with placebo or any active comparator." | 8.95 | Aspirin for acute treatment of episodic tension-type headache in adults. ( Derry, S; Moore, RA; Wiffen, PJ, 2017) |
| "Four randomized, controlled trials of identical design in 1,900 patients with episodic tension-type headache comparing acetylsalicylic acid, acetaminophen and caffeine vs." | 8.90 | Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies. ( Diener, HC; Gold, M; Hagen, M, 2014) |
| "(1) To establish whether pre-treatment headache intensity in migraine or episodic tension-type headache (ETTH) predicts success or failure of treatment with aspirin; and (2) to reflect, accordingly, on the place of aspirin in the management of these disorders." | 7.78 | Aspirin is first-line treatment for migraine and episodic tension-type headache regardless of headache intensity. ( Lampl, C; Steiner, TJ; Voelker, M, 2012) |
| " Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine." | 6.55 | Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017) |
| "We sought to compare the efficacy and safety profiles of aspirin, acetaminophen with codeine, and placebo in the treatment of post-operative dental pain and tension-type headache." | 5.16 | Assessment of the efficacy and safety profiles of aspirin and acetaminophen with codeine: results from 2 randomized, controlled trials in individuals with tension-type headache and postoperative dental pain. ( Fisher, M; Gatoulis, SC; Voelker, M, 2012) |
| "The results of this subgroup analysis confirm that the fixed combination of ASA (250 mg), paracetamol (200 mg), and caffeine (50 mg) is effective and well tolerated in a broad spectrum from mild to severe migraine and tension-type headache severity independently of the headache diagnosis." | 5.15 | The efficacy and tolerability of a fixed combination of acetylsalicylic acid, paracetamol, and caffeine in patients with severe headache: a post-hoc subgroup analysis from a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel g ( Aicher, B; Diener, HC; Peil, H, 2011) |
| " In a randomized double-blind study including individuals with either migraine or tension-type headache (TTH) we showed significant superiority of the fixed combination of acetylsalicylic acid + paracetamol + caffeine over the combination without caffeine, the single preparations, and placebo in the treatment of headache." | 5.14 | Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics. ( Aicher, B; Diener, HC; Lipton, RB; Pageler, L; Peil, H; Pfaffenrath, V, 2009) |
| "We investigated efficacy, safety, and tolerability of two tablets of the fixed combination of 250 mg acetylsalicylic acid (ASA) + 200 mg paracetamol + 50 mg caffeine (Thomapyrin) in comparison with two tablets of 250 mg ASA + 200 mg paracetamol, two tablets of 500 mg ASA, two tablets of 500 mg paracetamol, two tablets of 50 mg caffeine, and placebo in patients who were used to treating their episodic tension-type headache or migraine attacks with non-prescription analgesics." | 5.11 | The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group st ( Aicher, B; Diener, HC; Pageler, L; Peil, H; Pfaffenrath, V, 2005) |
| "Six randomized, double-blind, two-period crossover studies, conducted under similar protocols, compared the efficacy of two analgesic combinations containing caffeine with an acetaminophen 1000 mg control and with a placebo in outpatients with episodic tension-type headaches." | 5.07 | Caffeine as an analgesic adjuvant in tension headache. ( Armellino, JJ; Beaver, WT; Friedman, M; Gillings, DB; Migliardi, JR, 1994) |
| "To assess the efficacy and safety of aspirin for acute treatment of episodic tension-type headache (TTH) in adults compared with placebo or any active comparator." | 4.95 | Aspirin for acute treatment of episodic tension-type headache in adults. ( Derry, S; Moore, RA; Wiffen, PJ, 2017) |
| "Four randomized, controlled trials of identical design in 1,900 patients with episodic tension-type headache comparing acetylsalicylic acid, acetaminophen and caffeine vs." | 4.90 | Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies. ( Diener, HC; Gold, M; Hagen, M, 2014) |
| " Most of these patients suffer from migraine, tension-type headache, or a combination of the two; they tend to self-medicate using over the counter combination headache preparations, particularly acetylsalicyclic acid (ASA) and acetaminophen coformulated with caffeine, which is one of the most commonly used combination analgesics in these patients worldwide." | 4.86 | Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review. ( Anneken, K; Evers, S; Husstedt, IW, 2010) |
| "(1) To establish whether pre-treatment headache intensity in migraine or episodic tension-type headache (ETTH) predicts success or failure of treatment with aspirin; and (2) to reflect, accordingly, on the place of aspirin in the management of these disorders." | 3.78 | Aspirin is first-line treatment for migraine and episodic tension-type headache regardless of headache intensity. ( Lampl, C; Steiner, TJ; Voelker, M, 2012) |
| " All medications including placebo were almost equally safe and well tolerated." | 2.70 | Efficacy and safety of metamizol vs. acetylsalicylic acid in patients with moderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study. ( Cámara, J; Cornet, ME; Despuig, J; Díez-Tejedor, E; Fragoso, YD; Leira, R; Liaño, H; Martínez-Martín, P; Ortiz, P; Peil, H; Raffaelli, E; Titus, F; van Toor, BS; Vix, JM, 2001) |
| " Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine." | 2.55 | Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 11 (52.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lipton, RB | 2 |
| Diener, HC | 5 |
| Robbins, MS | 1 |
| Garas, SY | 1 |
| Patel, K | 1 |
| Gold, M | 1 |
| Hagen, M | 1 |
| Göbel, H | 1 |
| Heinze, A | 1 |
| Heinze-Kuhn, K | 1 |
| Göbel, A | 1 |
| Göbel, C | 1 |
| Derry, S | 1 |
| Wiffen, PJ | 1 |
| Moore, RA | 1 |
| Mayor, S | 1 |
| Pfaffenrath, V | 2 |
| Pageler, L | 2 |
| Peil, H | 4 |
| Aicher, B | 3 |
| Anneken, K | 1 |
| Evers, S | 1 |
| Husstedt, IW | 1 |
| Haag, G | 2 |
| Lampl, C | 1 |
| Voelker, M | 3 |
| Steiner, TJ | 2 |
| Ristic, D | 1 |
| Spangenberg, P | 1 |
| Ellrich, J | 1 |
| Gatoulis, SC | 1 |
| Fisher, M | 1 |
| Lange, R | 1 |
| RYAN, RE | 1 |
| Gaciong, Z | 1 |
| Farinelli, I | 1 |
| Martelletti, P | 1 |
| Migliardi, JR | 1 |
| Armellino, JJ | 1 |
| Friedman, M | 1 |
| Gillings, DB | 1 |
| Beaver, WT | 1 |
| Martínez-Martín, P | 1 |
| Raffaelli, E | 1 |
| Titus, F | 1 |
| Despuig, J | 1 |
| Fragoso, YD | 1 |
| Díez-Tejedor, E | 1 |
| Liaño, H | 1 |
| Leira, R | 1 |
| Cornet, ME | 1 |
| van Toor, BS | 1 |
| Cámara, J | 1 |
| Vix, JM | 1 |
| Ortiz, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649] | Phase 4 | 62 participants (Actual) | Interventional | 2020-02-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT03951649)
Timeframe: 7 days
| Intervention | days (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 1 |
(NCT03951649)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 9 |
| Oral Acetaminophen/Caffeine Group | 4 |
(NCT03951649)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 7 |
| Oral Acetaminophen/Caffeine Group | 2 |
Other: Pain at injection site (NCT03951649)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 0 |
| Oral Acetaminophen/Caffeine Group | 2 |
(NCT03951649)
Timeframe: 7 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 0 |
| Oral Acetaminophen/Caffeine Group | 0 |
(NCT03951649)
Timeframe: 4 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 9 |
| Oral Acetaminophen/Caffeine Group | 14 |
(NCT03951649)
Timeframe: 5 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 4 |
| Oral Acetaminophen/Caffeine Group | 2 |
Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 5 |
| Oral Acetaminophen/Caffeine Group | 1 |
(NCT03951649)
Timeframe: 120 min
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 5 |
| Oral Acetaminophen/Caffeine Group | 5 |
Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 20 |
| Oral Acetaminophen/Caffeine Group | 16 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 3 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 180min
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 4 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 2 hrs
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6.0 |
| Oral Acetaminophen/Caffeine Group | 6.5 |
8 reviews available for aspirin and Headache, Tension
| Article | Year |
|---|---|
Caffeine in the management of patients with headache.
Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan | 2017 |
Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies.
Topics: Acetaminophen; Analgesics; Aspirin; Caffeine; Double-Blind Method; Drug Therapy, Combination; Humans | 2014 |
[Peppermint oil in the acute treatment of tension-type headache].
Topics: Acetaminophen; Administration, Cutaneous; Adult; Aspirin; Child; Controlled Clinical Trials as Topic | 2016 |
Aspirin for acute treatment of episodic tension-type headache in adults.
Topics: Acetaminophen; Administration, Oral; Adult; Aged; Analgesics; Aspirin; Codeine; Dipyrone; Humans; Me | 2017 |
Efficacy of fixed combinations of acetylsalicyclic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Caffeine; Drug Combinations; Humans; Tens | 2010 |
The real dimension of analgesic activity of aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Comorbidity; Dose-Respon | 2003 |
[Self-medication of migraine and headache].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; | 2006 |
Aspirin and tension-type headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Tension-Type Headache | 2007 |
7 trials available for aspirin and Headache, Tension
| Article | Year |
|---|---|
Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Aspirin; Caffeine; Double-Blind Me | 2009 |
The efficacy and tolerability of a fixed combination of acetylsalicylic acid, paracetamol, and caffeine in patients with severe headache: a post-hoc subgroup analysis from a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel g
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2011 |
Assessment of the efficacy and safety profiles of aspirin and acetaminophen with codeine: results from 2 randomized, controlled trials in individuals with tension-type headache and postoperative dental pain.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Va | 2012 |
Aspirin in episodic tension-type headache: placebo-controlled dose-ranging comparison with paracetamol.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Dose-Response Relationship, Drug; Double-Blind Meth | 2003 |
The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group st
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; | 2005 |
Caffeine as an analgesic adjuvant in tension headache.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aspirin; Caffeine; Cross-Over Studies; Double-Blind Method; | 1994 |
Efficacy and safety of metamizol vs. acetylsalicylic acid in patients with moderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 2001 |
6 other studies available for aspirin and Headache, Tension
| Article | Year |
|---|---|
Aspirin for frequent episodic tension-type headache has limited evidence.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Tension-Type Headache | 2017 |
Comments on 'Efficacy of fixed combinations of acetylsalicylic acid, acetaminophen and caffeine in the treatment of idiopathic headache: a review'.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; | 2010 |
Aspirin is first-line treatment for migraine and episodic tension-type headache regardless of headache intensity.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Cross-Over Studie | 2012 |
Acetylsalicylic acid inhibits α,β-meATP-induced facilitation of neck muscle nociception in mice--implications for acute treatment of tension-type headache.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase In | 2011 |
TENSION HEADACHE: A NEW AGENT FOR ITS SYMPTOMATIC RELIEF.
Topics: Aspirin; Barbiturates; Caffeine; Diagnosis; Drug Therapy; Headache; Humans; Mental Disorders; Phenac | 1965 |
[Aspirin. Treatment of migraine and tension headaches].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Migraine Disorders; Tension-Type Headache | 2007 |