aspirin has been researched along with HbS Disease in 37 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the efficacy and tolerability of oral piroxicam 1 mg/kg/day with soluble aspirin given at 100 mg/kg/day taken four-hourly in 58 patients with sickle cell anaemia and severe ostcoarticular painful attacks requiring hospitalization in a randomized, paralleled study." | 9.09 | An open comparative study of dispersible piroxicam versus soluble acetylsalicylic acid for the treatment of osteoarticular painful attack during sickle cell crisis. ( Eke, FU; Eke, NN; Obamyonyi, A; Oyewo, EA, 2000) |
| "Aspirin ingestion was followed by hyperventilation, cerebellar signs, and fatal brain stem dysfunction in a patient with sickle cell disease." | 7.66 | Aspirin, hyperventilation, and cerebellar infarction in sickle cell disease. ( Arnow, PM; Garvin, JS; Panwalker, A; Rodriguez-Erdmann, F, 1978) |
| "Pregnancy in sickle cell disease is fraught with many complications including pre-eclampsia (PE) and intrauterine growth restriction (IUGR)." | 7.01 | Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy (PIPSICKLE): a randomised controlled trial (study protocol). ( Adeyemo, TA; Afolabi, BB; Babah, OA; Ezeaka, CV; Nwaiwu, O; Odukoya, OO; Ogunnaike, BA; Oshodi, YA, 2021) |
| "We compared the efficacy and tolerability of oral piroxicam 1 mg/kg/day with soluble aspirin given at 100 mg/kg/day taken four-hourly in 58 patients with sickle cell anaemia and severe ostcoarticular painful attacks requiring hospitalization in a randomized, paralleled study." | 5.09 | An open comparative study of dispersible piroxicam versus soluble acetylsalicylic acid for the treatment of osteoarticular painful attack during sickle cell crisis. ( Eke, FU; Eke, NN; Obamyonyi, A; Oyewo, EA, 2000) |
| "The effects of low doses of aspirin on the frequency and severity of painful vaso-occlusive crises were evaluated in children with sickle hemoglobinopathies." | 5.05 | Trial of low doses of aspirin as prophylaxis in sickle cell disease. ( Greenberg, J; Halus, J; Ohene-Frempong, K; Schwartz, E; Way, C, 1983) |
| " The Task Force has: 1) dropped the age for routine screening for Chlamydia in sexually active women from 25 years and younger to 24 and younger; 2) added a recommendation against the use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent colorectal cancer (CRC); 3) changed its recommendation on screening for carotid artery stenosis." | 3.74 | Should you screen--or not? The latest recommendations. ( Campos-Outcalt, D, 2008) |
| "Aspirin ingestion was followed by hyperventilation, cerebellar signs, and fatal brain stem dysfunction in a patient with sickle cell disease." | 3.66 | Aspirin, hyperventilation, and cerebellar infarction in sickle cell disease. ( Arnow, PM; Garvin, JS; Panwalker, A; Rodriguez-Erdmann, F, 1978) |
| "Pregnancy in sickle cell disease is fraught with many complications including pre-eclampsia (PE) and intrauterine growth restriction (IUGR)." | 3.01 | Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy (PIPSICKLE): a randomised controlled trial (study protocol). ( Adeyemo, TA; Afolabi, BB; Babah, OA; Ezeaka, CV; Nwaiwu, O; Odukoya, OO; Ogunnaike, BA; Oshodi, YA, 2021) |
| "The Stroke Prevention Trial in Sickle Cell Anemia (STOP) reported a reduction in the number of overt clinical strokes experienced by those children with critically high transcranial Doppler velocities (>200 centimeters per second) who were chronically transfused." | 2.43 | Trials in sickle cell disease. ( Adams, RJ; Datta, AK; DeBaun, MR; Kirkham, FJ; Lerner, NB; Noetzel, M; Rees, DC, 2006) |
| "Stroke is a traumatic complication in sickle cell anaemia (SCA) that is associated with significant morbidity and a risk of recurrent overt stroke of 2·2-6·4 events per 100 patient-years." | 1.40 | Outcome of overt stroke in sickle cell anaemia, a single institution's experience. ( Forsythe, A; Gordon, C; Iyer, R; Khan, M; Majumdar, S; Megason, G; Miller, M; Smith, MG, 2014) |
| "Sickle cell disease is considered protective against large vessel coronary artery disease." | 1.32 | Acute myocardial infarction in a young man with sickle cell disease. ( Sherman, SC; Sulé, HP, 2004) |
| "However, in sickle cell anemia, does the obligate period of flap ischemia inherent in free-tissue transfer inevitably doom a flap to failure? We present our multidisciplinary experience over 55 months with five free flaps in four homozygous sickle cell anemia patients 21 to 38 years old who had chronic nonhealing leg ulcerations." | 1.29 | Lower limb salvage by microvascular free-tissue transfer in patients with homozygous sickle cell disease. ( Koshy, M; Marschall, M; Schuler, J; Weinzweig, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (54.05) | 18.7374 |
| 1990's | 5 (13.51) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 3 (8.11) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Melo, TRF | 1 |
| Kumkhaek, C | 1 |
| Fernandes, GFDS | 1 |
| Lopes Pires, ME | 1 |
| Chelucci, RC | 1 |
| Barbieri, KP | 1 |
| Coelho, F | 1 |
| Capote, TSO | 1 |
| Lanaro, C | 1 |
| Carlos, IZ | 1 |
| Marcondes, S | 1 |
| Chegaev, K | 1 |
| Guglielmo, S | 1 |
| Fruttero, R | 1 |
| Chung, MC | 1 |
| Costa, FF | 2 |
| Rodgers, GP | 1 |
| Dos Santos, JL | 1 |
| Runge, A | 1 |
| Brazel, D | 1 |
| Pakbaz, Z | 1 |
| Afolabi, BB | 1 |
| Babah, OA | 1 |
| Adeyemo, TA | 1 |
| Odukoya, OO | 1 |
| Ezeaka, CV | 1 |
| Nwaiwu, O | 1 |
| Oshodi, YA | 1 |
| Ogunnaike, BA | 1 |
| Han, J | 1 |
| Saraf, SL | 1 |
| Lash, JP | 1 |
| Gordeuk, VR | 1 |
| Majumdar, S | 1 |
| Miller, M | 1 |
| Khan, M | 1 |
| Gordon, C | 1 |
| Forsythe, A | 1 |
| Smith, MG | 1 |
| Megason, G | 1 |
| Iyer, R | 1 |
| Campos-Outcalt, D | 1 |
| Wong, F | 1 |
| Sherman, SC | 1 |
| Sulé, HP | 1 |
| Kirkham, FJ | 1 |
| Lerner, NB | 1 |
| Noetzel, M | 1 |
| DeBaun, MR | 1 |
| Datta, AK | 1 |
| Rees, DC | 1 |
| Adams, RJ | 1 |
| Chang, H | 1 |
| Ewert, SM | 1 |
| Bookchin, RM | 1 |
| Nagel, RL | 1 |
| Zago, MA | 1 |
| Ismael, SJ | 1 |
| Tone, LG | 1 |
| Bottura, C | 1 |
| Osamo, NO | 1 |
| Photiades, DP | 1 |
| Famodu, AA | 1 |
| Ozsoylu, S | 1 |
| Greenberg, J | 1 |
| Ohene-Frempong, K | 1 |
| Halus, J | 1 |
| Way, C | 1 |
| Schwartz, E | 1 |
| Chaplin, H | 2 |
| Alkjaersig, N | 2 |
| Fletcher, AP | 1 |
| Michael, JM | 1 |
| Joist, JH | 1 |
| Klotz, IM | 1 |
| Haney, DN | 1 |
| King, LC | 1 |
| Weinzweig, N | 1 |
| Schuler, J | 1 |
| Marschall, M | 1 |
| Koshy, M | 1 |
| Foulon, I | 1 |
| Bachir, D | 1 |
| Galacteros, F | 1 |
| Maclouf, J | 1 |
| Eke, FU | 1 |
| Obamyonyi, A | 1 |
| Eke, NN | 1 |
| Oyewo, EA | 1 |
| Salawu, L | 1 |
| Olaomi, OO | 1 |
| Paul-Odo, B | 1 |
| Olayinka, OS | 1 |
| Durosinmi, MA | 1 |
| Rezaei Kalantari, H | 1 |
| Burry, A | 1 |
| Cross, R | 1 |
| Axelsen, R | 1 |
| Arnow, PM | 1 |
| Panwalker, A | 1 |
| Garvin, JS | 1 |
| Rodriguez-Erdmann, F | 1 |
| Diamond, HS | 1 |
| Meisel, AD | 1 |
| Fletcher, A | 1 |
| Joist, H | 1 |
| Phadke, MA | 1 |
| Kate, SL | 1 |
| Sainami, GS | 1 |
| Mutalik, GS | 1 |
| Phadke, MV | 1 |
| Baxi, AJ | 1 |
| Zucker, P | 1 |
| Daum, F | 1 |
| Cohen, MI | 1 |
| Longenecker, GL | 1 |
| Beyers, BJ | 1 |
| Mankad, VN | 1 |
| Antonucci, R | 1 |
| Walker, R | 1 |
| Herion, J | 1 |
| Orringer, E | 1 |
| Janka-Schaub, G | 1 |
| Mullick, FG | 1 |
| Delage, C | 1 |
| Irey, NS | 1 |
| Paniker, NV | 1 |
| Ben-Bassat, I | 1 |
| Beutler, E | 1 |
| Huntsman, RG | 1 |
| Lehmann, H | 1 |
| De Furia, FG | 1 |
| Cerami, A | 1 |
| Bunn, HF | 1 |
| Lu, YS | 1 |
| Peterson, CM | 1 |
| Athreya, BH | 1 |
| Gorske, AL | 1 |
| Myers, AR | 1 |
| Rabinowitz, IN | 1 |
| Wolf, PL | 1 |
| Berman, S | 1 |
6 reviews available for aspirin and HbS Disease
| Article | Year |
|---|---|
Stroke in sickle cell disease and the promise of recent disease modifying agents.
Topics: Adult; Anemia, Sickle Cell; Anticoagulants; Aspirin; Cerebral Infarction; Humans; Hydroxyurea; Strok | 2022 |
Liver and kidney diseases.
Topics: Acetaminophen; Anemia, Sickle Cell; Animals; Aspirin; Cholestasis; Cysts; Glomerulonephritis, IGA; G | 2002 |
Trials in sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Aspirin; Blood Transfusion; Child; Child, Preschool; Clinical Trial | 2006 |
Comparative evaluation of fifteen anti-sickling agents.
Topics: Anemia, Sickle Cell; Antisickling Agents; Aspirin; Azepines; Carbamyl Phosphate; Cyanates; Cystamine | 1983 |
[How I treat ... sickle cell anemia: current therapies].
Topics: Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antisickling Agents; A | 2001 |
Analgesic nephropathy and the renal concentrating mechanism.
Topics: Aging; Amyloidosis; Analgesics; Anemia, Sickle Cell; Animals; Aspirin; Calcinosis; Dehydration; Diab | 1977 |
6 trials available for aspirin and HbS Disease
| Article | Year |
|---|---|
Low-dose aspirin for preventing intrauterine growth restriction and pre-eclampsia in sickle cell pregnancy (PIPSICKLE): a randomised controlled trial (study protocol).
Topics: Anemia, Sickle Cell; Aspirin; Female; Fetal Growth Retardation; Humans; Nigeria; Placenta; Pre-Eclam | 2021 |
Treatment of sickle cell diseases with aspirin.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Aspirin; Child; Child, Preschool; Clinical Trials as Topic; | 1984 |
Therapeutic effect of aspirin in sickle cell anaemia.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Aspirin; Child; Clinical Trials as Topic; Double-Blind Metho | 1981 |
Trial of low doses of aspirin as prophylaxis in sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Aspirin; Blood Platelets; Child; Child, Preschool; Double-Blind Met | 1983 |
Aspirin-dipyridamole prophylaxis of sickle cell disease pain crises.
Topics: Acute Disease; Anemia, Sickle Cell; Aspirin; Clinical Trials as Topic; Dipyridamole; Drug Therapy, C | 1980 |
An open comparative study of dispersible piroxicam versus soluble acetylsalicylic acid for the treatment of osteoarticular painful attack during sickle cell crisis.
Topics: Adolescent; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Aspirin; Bone | 2000 |
25 other studies available for aspirin and HbS Disease
| Article | Year |
|---|---|
Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation.
Topics: Acetic Acid; Acetylation; Anemia, Sickle Cell; Dose-Response Relationship, Drug; Drug Discovery; gam | 2018 |
Use of anti-inflammatory analgesics in sickle-cell disease.
Topics: Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, D | 2017 |
Outcome of overt stroke in sickle cell anaemia, a single institution's experience.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Aspirin; Child; Erythrocyte Transfusion; Female; Humans; Mal | 2014 |
Should you screen--or not? The latest recommendations.
Topics: Adult; Alcohol Drinking; Anemia, Sickle Cell; Aspirin; Chlamydia Infections; Colorectal Neoplasms; F | 2008 |
Acute myocardial infarction in a young man with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Aspirin; Chest Pain; Diagnosis, Differential; Electrocardiography; Emerg | 2004 |
Aspirin in sickle-cell anaemia.
Topics: Anemia, Sickle Cell; Aspirin; Humans | 1982 |
Rational approaches to chemotherapy: antisickling agents.
Topics: Anemia, Sickle Cell; Aspirin; Chemical Phenomena; Chemistry; Hemoglobin, Sickle; Humans; Protein Bin | 1981 |
Lower limb salvage by microvascular free-tissue transfer in patients with homozygous sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Anti-Bacterial Agents; Aspirin; Dextrans; Exchange Transfusion, Whole Bl | 1995 |
Increased in vivo production of thromboxane in patients with sickle cell disease is accompanied by an impairment of platelet functions to the thromboxane A2 agonist U46619.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Anemia, Sickle Cell; Aspirin; Blood Platelets; Fema | 1993 |
Aspirin-induced duodenal perforation in a Nigerian with sickle cell disease: a case report.
Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Hum | 2001 |
Aspirin, hyperventilation, and cerebellar infarction in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Aspirin; Cerebellum; Humans; Hyperventilation; Infarction; Male | 1978 |
Classification of uricosuric states based upon response to pharmacologic inhibitors of urate transport.
Topics: Anemia, Sickle Cell; Aspirin; Biological Transport; Diatrizoate; Fanconi Syndrome; Glomerular Filtra | 1977 |
Hemostatic alterations accompanying sickle cell pain crises.
Topics: Acute Disease; Adult; Anemia, Sickle Cell; Aspirin; Blood Cell Count; Blood Platelets; Blood Transfu | 1976 |
Hyperhaemolytic and vascular occlusive crises in sickle cell disease. A case report with brief review of literature.
Topics: Anemia, Hemolytic; Anemia, Sickle Cell; Aspirin; Child; Glucosephosphate Dehydrogenase Deficiency; H | 1975 |
Aspirin hepatitis.
Topics: Adolescent; Anemia, Sickle Cell; Arthritis, Juvenile; Aspartate Aminotransferases; Aspirin; Chemical | 1975 |
Platelet regulatory prostanoids and platelet release products in sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Aspirin; beta-Thromboglobulin; Blood Platelets; Epoprostenol; Human | 1992 |
Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets.
Topics: Anemia, Sickle Cell; Aspirin; Blood Platelets; Cell Adhesion; Endothelium, Vascular; Epoprostenol; E | 1990 |
[Therapy of sickle cell crisis].
Topics: Analgesics; Anemia, Sickle Cell; Aspirin; Child; Child, Preschool; Fluid Therapy; Heterozygote; Huma | 1990 |
Sickle cell crisis associated with drugs.
Topics: Adult; Anemia, Sickle Cell; Aspirin; Autopsy; Chlordiazepoxide; Dextropropoxyphene; Female; Humans; | 1973 |
Evaluation of sickle hemoglobin and desickling agents by falling ball viscometry.
Topics: 6-Phytase; Anemia, Sickle Cell; Aspirin; Blood Viscosity; Carbamates; Cyanates; Drug Storage; Fructo | 1972 |
Treatment of sickle-cell disease.
Topics: Anemia, Sickle Cell; Anesthesia; Anticoagulants; Aspirin; Bicarbonates; Blood; Blood Flow Velocity; | 1974 |
The effect of aspirin on sickling and oxygen affinity of erythrocytes.
Topics: Anemia, Sickle Cell; Animals; Arthritis, Rheumatoid; Aspirin; Carbon Radioisotopes; Diphosphoglyceri | 1973 |
Aspirin-induced abnormalities of liver function.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anemia, Sickle Cell; Arthritis, Juvenile; Aspartate Amin | 1973 |
Light scattering studies of retardation of sickling by aspirin-like drugs.
Topics: Analgesics; Anemia, Sickle Cell; Anti-Inflammatory Agents; Aspirin; Erythrocytes; Erythrocytes, Abno | 1974 |
Medical grand rounds from the University of Alabama Medical Center.
Topics: Adult; Anemia, Sickle Cell; Animals; Arthritis, Rheumatoid; Aspirin; Biopsy; Blood Urea Nitrogen; Di | 1969 |