aspirin has been researched along with Hay Fever in 43 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Excerpt | Relevance | Reference |
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"The evidence from observational studies on the association between the use of aspirin and the risk of hayfever or allergic rhinitis is conflicting, with a dearth of high-quality randomized controlled trials." | 8.31 | Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study. ( Chen, W; Fu, Z; Jiang, J; Li, J; Li, L; Liu, H; Liu, X; Yang, Q; Zhang, Y, 2023) |
"Chronic rhinosinusitis with nasal polyposis may be a symptom of aspirin-intolerance." | 7.65 | [Rhinosinusitis polyposa as the only symptom of aspirin intolerance -- a rhinorheomanometric diagnosis (author's transl)]. ( Enzmann, H; Kühn, H, 1977) |
" Association of bronchial asthma, nasal pathology and intolerance to aspirin is a unique syndrome." | 4.75 | Aspirin intolerance--a review. ( Abrishami, MA; Thomas, J, 1977) |
"The evidence from observational studies on the association between the use of aspirin and the risk of hayfever or allergic rhinitis is conflicting, with a dearth of high-quality randomized controlled trials." | 4.31 | Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study. ( Chen, W; Fu, Z; Jiang, J; Li, J; Li, L; Liu, H; Liu, X; Yang, Q; Zhang, Y, 2023) |
"We recently found that paracetamol (acetaminophen) use in late pregnancy was associated with an increased risk of early wheezing in the offspring." | 3.73 | Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. ( Headley, JE; Henderson, AJ; Jones, RW; Newson, RB; Shaheen, SO; Strachan, DP; Stratton, FD, 2005) |
" There was no significant difference between the polyp histamine levels in patients with a history of asthma, aspirin hypersensitivity, hay fever and positive skin tests." | 3.67 | Free histamine in nasal polyp fluid. ( Bickerton, R; Drake-Lee, AB; McLaughlan, P, 1984) |
" Before immunotherapy, all patients had a complete evaluation of the severity of asthma by symptom-medication scores and a pulmonary function test, as well as a study of other triggering factors by checking on seasonal and perennial allergens, sinusitis, and other possible causes, such as aspirin intolerance; 196 patients were investigated between 9 and 12 months after the onset of the survey by means of pulmonary function tests and symptom-medication scores." | 3.67 | Specific immunotherapy with a standardized Dermatophagoides pteronyssinus extract. II. Prediction of efficacy of immunotherapy. ( Bousquet, J; Clauzel, AM; Dhivert, H; Guérin, B; Hejjaoui, A; Michel, FB; Skassa-Brociek, W, 1988) |
"Adverse reactions (urticaria, angio-edema, bronchoconstriction, purpura) to Aspirin (ASS) and food-and-drug additives such as the yellow dye tartrazine and the preservative benzoate are observed all over the world." | 3.66 | [Acetylsalicylic acid and food additive intolerance in urticaria, bronchial asthma and rhinopathy]. ( Fabro, L; Wüthrich, B, 1981) |
"Chronic rhinosinusitis with nasal polyposis may be a symptom of aspirin-intolerance." | 3.65 | [Rhinosinusitis polyposa as the only symptom of aspirin intolerance -- a rhinorheomanometric diagnosis (author's transl)]. ( Enzmann, H; Kühn, H, 1977) |
"Patients manifesting intrinsic idiopathic rhinitis and/or asthma in association with diabetes or aspirin intolerance were studied." | 3.65 | Intrinsic asthma associated with diabetes mellitus; abnormal vascular response and glucose tolerance tests. ( Cohen, GN; Fisherman, EW, 1975) |
"Evidence has been presented supporting the hypothesis that at least 2 different types of mechanisms may be involved in aspirin intolerance, one resulting in bronchospasm and the other producing urticaria/angioedema." | 3.65 | Aspirin intolerance. III. Subtypes, familial occurence, and cross-reactivity with tartarazine. ( Pudupakkam, RK; Settipane, GA, 1975) |
"Pretreatment with aspirin reduces the levels of cyclooxygenase metabolites in nasal secretions without affecting the immediate physiologic response to antigen or the expected increase in the levels of histamine, N-alpha-tosyl-L-arginine methyl ester-esterase activity, and leukotriene C4." | 2.66 | Experimentally induced nasal allergic responses. ( Adkinson, NF; Bascom, R; Kagey-Sobotka, A; Lichtenstein, LM; Naclerio, RM; Proud, D; Walden, SM, 1988) |
"However, indomethacin-induced nasal blockage was not provoked in non-sensitized animals." | 1.34 | Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis. ( Fujii, M; Han, HY; Kohno, S; Mizutani, N; Nabe, T; Takenaka, H; Terada, T, 2007) |
"The cause of nasal polyps is speculative." | 1.29 | [The viral and allergic origin of nasal polyposis]. ( Braun, W; Bürkle, H; Klima, A; May, A, 1993) |
"Among adult patients with bronchial asthma and/or allergic rhinitis undergoing allergological investigation with skin test, nasal provocation test and RAST, 1129 answered a questionaire regarding food sensitivity (FS)." | 1.26 | Food sensitivity reported by patients with asthma and hay fever. A relationship between food sensitivity and birch pollen-allergy and between food sensitivity and acetylsalicylic acid intolerance. ( Eriksson, NE, 1978) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 34 (79.07) | 18.7374 |
1990's | 4 (9.30) | 18.2507 |
2000's | 4 (9.30) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (2.33) | 2.80 |
Authors | Studies |
---|---|
Li, L | 1 |
Zhang, Y | 1 |
Liu, X | 1 |
Li, J | 1 |
Yang, Q | 1 |
Jiang, J | 1 |
Liu, H | 1 |
Fu, Z | 1 |
Chen, W | 1 |
BRUUN, E | 1 |
Fox, RW | 1 |
Lockey, RF | 1 |
Shaheen, SO | 1 |
Newson, RB | 1 |
Henderson, AJ | 1 |
Headley, JE | 1 |
Stratton, FD | 1 |
Jones, RW | 1 |
Strachan, DP | 1 |
Han, HY | 1 |
Nabe, T | 1 |
Mizutani, N | 1 |
Fujii, M | 1 |
Terada, T | 1 |
Takenaka, H | 1 |
Kohno, S | 1 |
McLean, JA | 1 |
Bacon, JR | 1 |
Mathews, KP | 1 |
Banas, J | 1 |
Capati, D | 1 |
Bayne, NK | 1 |
Drake-Lee, AB | 2 |
Bickerton, R | 1 |
McLaughlan, P | 1 |
Lowe, D | 1 |
Swanston, A | 1 |
Grace, A | 1 |
Juhlin, L | 2 |
Wüthrich, B | 1 |
Fabro, L | 1 |
Miraglia Del Giudice, M | 1 |
Marano, C | 1 |
Maiello, N | 1 |
Capristo, A | 1 |
Salzano, V | 1 |
Klima, A | 1 |
Bürkle, H | 1 |
May, A | 1 |
Braun, W | 1 |
Davies, RJ | 1 |
Wang, J | 1 |
Abdelaziz, MM | 1 |
Calderon, MA | 1 |
Khair, O | 1 |
Devalia, JL | 1 |
Rusznak, C | 1 |
Hedman, J | 1 |
Kaprio, J | 1 |
Poussa, T | 1 |
Nieminen, MM | 1 |
Modrzyński, M | 1 |
Wróbel, B | 1 |
Zawisza, E | 1 |
Grochowski, P | 1 |
Mygind, N | 1 |
Enzmann, H | 1 |
Kühn, H | 1 |
Abrishami, MA | 1 |
Thomas, J | 1 |
Bhandari, CM | 1 |
Rosenhall, L | 3 |
Deuschl, H | 1 |
Eriksson, NE | 1 |
Settipane, GA | 3 |
Chafee, FH | 2 |
Dahl, R | 1 |
Zetterström, O | 2 |
Fisherman, EW | 2 |
Cohen, GN | 2 |
Pudupakkam, RK | 1 |
Szczeklik, A | 2 |
Schmitz-Schumann, M | 1 |
Krzanowski, M | 2 |
Virchow, C | 1 |
Brown, MS | 1 |
Peters, SP | 1 |
Adkinson, NF | 2 |
Proud, D | 2 |
Kagey-Sobotka, A | 2 |
Norman, PS | 1 |
Lichtenstein, LM | 2 |
Naclerio, RM | 2 |
Bousquet, J | 1 |
Hejjaoui, A | 1 |
Clauzel, AM | 1 |
Guérin, B | 1 |
Dhivert, H | 1 |
Skassa-Brociek, W | 1 |
Michel, FB | 1 |
Walden, SM | 1 |
Bascom, R | 1 |
Nizankowska, E | 1 |
Musial, J | 1 |
Henderson, LL | 1 |
Swedlund, HA | 1 |
Van Dellen, RG | 1 |
Marcoux, JP | 1 |
Carryer, HM | 1 |
Peters, GA | 1 |
Gleich, GJ | 1 |
Borodin, IuP | 1 |
Sharapova, SV | 1 |
Houdard, YP | 1 |
Stahl, RH | 1 |
Johannessen, H | 1 |
Yunginger, JW | 1 |
O'Connell, EJ | 1 |
Logan, GB | 1 |
Atkinson, JA | 1 |
Michaëlsson, G | 1 |
Falliers, CJ | 1 |
Klein, DE | 1 |
Lockey, SD | 1 |
Champion, RH | 1 |
Roberts, SO | 1 |
Carpenter, RG | 1 |
Roger, JH | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
'The Factors Associated With the Formation of Nasal Polyp'[NCT01278719] | 180 participants (Anticipated) | Observational | 2010-01-31 | Recruiting | |||
Challenge Test for Acetylsalicylic Acid Hypersensitivity[NCT01681615] | 50 participants (Anticipated) | Interventional | 2012-09-30 | Not yet recruiting | |||
Effects of Anti-IgE Antibody Omalizumab (Xolair) on Patients With Chronic Sinusitis and a Positive Allergen Test[NCT00117611] | Phase 4 | 14 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
Prospective Observational Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab[NCT03369574] | 0 participants (Actual) | Observational | 2017-11-14 | Withdrawn (stopped due to Study personnel diverted to other activities and the study was not commenced) | |||
Randomized, Double-blinded, Placebo-controlled, Prospective, Multicenter Trial to Evaluate the Efficacy and Safety of SIC in Subjects With Mild/Moderate Asthma and Rhinitis/Rhinoconjunctivitis Sensitized to D.Pteronyssinus and/or D. Farinae[NCT04435990] | Phase 3 | 150 participants (Anticipated) | Interventional | 2020-10-06 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 reviews available for aspirin and Hay Fever
Article | Year |
---|---|
The impact of rhinosinusitis on asthma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Common Cold; Humans; Rhinitis; Rhinitis, A | 2003 |
Incidence of intolerance to food additives.
Topics: Angioedema; Aspirin; Asthma; Azo Compounds; Benzoates; Dermatitis, Contact; Food Additives; Food Hyp | 1980 |
New insights into the understanding of asthma.
Topics: Air Pollutants; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchi; Chronic Disease; | 1997 |
Immunohistopathology of allergic rhinitis and conditions allied.
Topics: Antigen-Antibody Reactions; Aspirin; Drug Tolerance; Eosinophils; Epithelium; Epitopes; Humans; Immu | 1978 |
Aspirin intolerance--a review.
Topics: Adolescent; Adult; Age Factors; Aged; Angioedema; Aspirin; Asthma; Blood Coagulation; Child; Child, | 1977 |
[Bronchial asthma caused by dyes].
Topics: Aspirin; Asthma; Azo Compounds; Coloring Agents; Conjunctivitis; Drug Hypersensitivity; Food Additiv | 1973 |
4 trials available for aspirin and Hay Fever
Article | Year |
---|---|
Effects of aspirin on nasal responses in atopic subjects.
Topics: Administration, Intranasal; Administration, Oral; Airway Resistance; Allergens; Aspirin; Binding, Co | 1983 |
Experimentally induced nasal allergic responses.
Topics: Antigens; Aspirin; Fluocinolone Acetonide; Humans; Hypersensitivity, Delayed; Mast Cells; Nasal Prov | 1988 |
Bleeding time and PAF-acether-induced platelet aggregation in atopy.
Topics: Adult; Aspirin; Asthma; Bleeding Time; Female; Humans; Male; Middle Aged; Platelet Activating Factor | 1987 |
[Urticaria provoked by preservatives and coloring agents in food and drugs].
Topics: Angioedema; Aspirin; Asthma; Azo Compounds; Benzoates; Chemical Phenomena; Chemistry; Food Additives | 1973 |
33 other studies available for aspirin and Hay Fever
Article | Year |
---|---|
Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study.
Topics: Aspirin; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Rhinitis, Allergic | 2023 |
[DRUG ALLERGY IN PATIENTS SUFFERING FROM ALLERGIC DISEASES WITH IMMEDIATE REACTION].
Topics: Anaphylaxis; Anti-Bacterial Agents; Aspirin; Asthma; Barbiturates; Codeine; Drug Eruptions; Drug Hyp | 1964 |
Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; As | 2005 |
Nasal blockage induced by oral administration of non-steroidal anti-inflammatory drugs in a guinea-pig model of allergic rhinitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromones; Diclofen | 2007 |
Free histamine in nasal polyp fluid.
Topics: Aspirin; Asthma; Drug Hypersensitivity; Extracellular Space; Histamine; Humans; Hypersensitivity; Na | 1984 |
Clinical profile and recurrence of nasal polyps.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Eczema; Female; Humans; Male; Middl | 1984 |
[Acetylsalicylic acid and food additive intolerance in urticaria, bronchial asthma and rhinopathy].
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Child; Drug Hypersensitivity; Female; Food Additives; Food | 1981 |
[Bronchomotor manifestations caused by acetylsalicylic acid. Research on a group of children with allergic asthma].
Topics: Aspirin; Asthma; Child; Female; Humans; Lung; Male; Respiratory Function Tests; Rhinitis, Allergic, | 1981 |
[The viral and allergic origin of nasal polyposis].
Topics: Aspirin; Asthma; Drug Hypersensitivity; Humans; Immunoglobulin E; Intradermal Tests; Nasal Polyps; R | 1993 |
Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Female; Finland; Humans; Lung Disea | 1999 |
Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Female; Finland; Humans; Lung Disea | 1999 |
Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Female; Finland; Humans; Lung Disea | 1999 |
Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study.
Topics: Adolescent; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Female; Finland; Humans; Lung Disea | 1999 |
[A case of choanal polyp in a man with aspirin triad and pollinosis].
Topics: Adult; Aspirin; Drug Hypersensitivity; Humans; Male; Nasal Polyps; Recurrence; Rhinitis, Allergic, S | 2000 |
[Rhinosinusitis polyposa as the only symptom of aspirin intolerance -- a rhinorheomanometric diagnosis (author's transl)].
Topics: Aspirin; Drug Hypersensitivity; Female; Humans; Manometry; Maxillary Sinus; Middle Aged; Nasal Polyp | 1977 |
Immunoglobulins in serum and nasal secretion. A comparison between patients with aspirin hypersensitivity and allergic rhinitis.
Topics: Adult; Aged; Aspirin; Drug Hypersensitivity; Female; Humans; Immunoglobulin A; Immunoglobulin E; Imm | 1977 |
Food sensitivity reported by patients with asthma and hay fever. A relationship between food sensitivity and birch pollen-allergy and between food sensitivity and acetylsalicylic acid intolerance.
Topics: Adolescent; Adult; Aged; Allergens; Aspirin; Asthma; Child; Female; Food Hypersensitivity; Humans; M | 1978 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
Nasal polyps in asthma and rhinitis. A review of 6,037 patients.
Topics: Adolescent; Adult; Aging; Aspirin; Asthma; Child; Child, Preschool; Drug Hypersensitivity; Female; H | 1977 |
[Aspirin disease. Bronchial asthma and rhinitis caused by analgesics, food coloring agents and food preservatives].
Topics: Adult; Aspirin; Asthma; Drug Hypersensitivity; Female; Food Coloring Agents; Food Preservatives; Hum | 1976 |
Intrinsic asthma associated with diabetes mellitus; abnormal vascular response and glucose tolerance tests.
Topics: Aspirin; Asthma; Blood Coagulation Tests; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Diabet | 1975 |
Aspirin intolerance. III. Subtypes, familial occurence, and cross-reactivity with tartarazine.
Topics: Angioedema; Aspirin; Asthma; Azo Compounds; Benzenesulfonates; Bronchial Spasm; Cross Reactions; Dru | 1975 |
Delayed generation of thrombin in clotting blood of atopic patients with hayfever and asthma.
Topics: Aspirin; Asthma; Bleeding Time; Fibrinopeptide A; Hemostasis; Humans; Rhinitis, Allergic, Seasonal; | 1991 |
Arachidonic acid metabolites during nasal challenge.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Female; Histamine | 1987 |
Specific immunotherapy with a standardized Dermatophagoides pteronyssinus extract. II. Prediction of efficacy of immunotherapy.
Topics: Adolescent; Adult; Aged; Allergens; Animals; Antigens, Dermatophagoides; Aspirin; Asthma; Child; Chi | 1988 |
Alpha-beta-adrenergic imbalance in intrinsic-intolerance rhinitis or asthma.
Topics: Adrenergic beta-Antagonists; Anisoles; Aspirin; Asthma; Blood Coagulation Tests; Drug Hypersensitivi | 1974 |
Evaluation of IgE tests in an allergy practice.
Topics: Aspirin; Asthma; Drug Hypersensitivity; Food Hypersensitivity; Humans; Immunoglobulin E; Immunoglobu | 1971 |
[Study of leukergy in drug allergy].
Topics: Aminopyrine; Anaphylaxis; Angioedema; Aspirin; Asthma; Cell Aggregation; Conjunctivitis; Drug Erupti | 1971 |
[Trial of cortibucline].
Topics: Administration, Oral; Adult; Aged; Ascorbic Acid; Aspirin; Asthma; Drug Combinations; Female; Histam | 1969 |
Allergic disorders of the nose and paranasal sinuses.
Topics: Aspirin; Drug Hypersensitivity; Dust; Humans; Nasal Polyps; Pollen; Rhinitis, Allergic, Seasonal; Si | 1974 |
Aspirin-induced asthma in children.
Topics: Adolescent; Age Factors; Aspirin; Asthma; Child; Drug Hypersensitivity; Eczema; Eosinophils; Female; | 1973 |
A case of allergy to aspirin.
Topics: Aspirin; Asthma; Drug Hypersensitivity; Humans; Male; Rhinitis, Allergic, Seasonal | 1973 |
[Asthma provoked by analgesics, food colors and preservatives].
Topics: Adolescent; Adult; Aged; Angioedema; Aspirin; Asthma; Azo Compounds; Benzoates; Female; Food Additiv | 1973 |
Aspirin and subtypes of asthma: risk factor analysis.
Topics: Adolescent; Age Factors; Aspirin; Asthma; Child; Chronic Disease; Drug Hypersensitivity; Eczema; Fem | 1973 |
Aspirin intolerance. II. A prospective study in an atopic and normal population.
Topics: Allergens; Angioedema; Aspirin; Asthma; Bronchial Spasm; Drug Hypersensitivity; Female; Humans; Male | 1974 |
Reactions to hidden agents in foods, beverages and drugs.
Topics: Adult; Allergens; Anaphylaxis; Aspirin; Asthma; Azo Compounds; Beverages; Child; Child, Preschool; C | 1971 |
Urticaria and angio-oedema. A review of 554 patients.
Topics: Adolescent; Adult; Age Factors; Aged; Angioedema; Aspirin; Asthma; Computers; Dermatitis, Atopic; Dr | 1969 |