aspirin has been researched along with Glial Cell Tumors in 18 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting." | 9.01 | Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis. ( Ali-Osman, F; Amirian, ES; Amos, CI; Armstrong, GN; Barnholtz-Sloan, JS; Bernstein, JL; Bondy, ML; Claus, EB; Gu, X; Houlston, RS; Il'yasova, D; Jacobs, DI; Jalali, A; Jenkins, RB; Johansen, C; Lachance, DH; Lai, RK; Melin, B; Merrell, RT; Olson, SH; Ostrom, QT; Sadetzki, S; Scheurer, ME; Schildkraut, JM; Shete, S; Wrensch, MR, 2019) |
| "Clinically, high cyclooxygenase-2 expression in malignant glioma correlates well with poor prognosis and the use of aspirin is associated with a reduced risk of glioma." | 7.96 | Aspirin Induced Glioma Apoptosis through Noxa Upregulation. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Liao, SL; Ou, YC; Pan, PH; Wang, JD; Wang, WY, 2020) |
| "Few studies have examined the association between use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and risk of glioma and the results have been equivocal." | 7.79 | Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. ( Friis, S; Gaist, D; García-Rodríguez, LA; Hallas, J; Sørensen, HT, 2013) |
| " We studied the effect of various doses of ASA on the growth of C6 glioma implanted in rats as well as the effect of chronic administration of ASA on time of development and incidence of tumors of the central nervous system (CNS) induced by prenatal exposure to ethylnitrosourea (ENU)." | 7.71 | Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system. ( Arrieta, O; Guevara, P; Palencia, G; Reyes, S; Rivera, E; Sotelo, J, 2001) |
| " Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture." | 7.70 | Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 7.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| "Aspirin treatment inhibited cell proliferation and caused early apoptosis in glioma, coupled with reduced S100A9 levels." | 5.39 | Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin. ( Chen, S; Cheng, Y; Deng, J; Huang, N; Huang, Q; Liao, P; Wang, F, 2013) |
| "Aspirin microsphere treatment induced slight apoptosis and modestly inhibited proliferation of LN229 and U87 cells in vitro and in vivo through inhibition of β-catenin transactivation." | 5.39 | Aspirin-/TMZ-coloaded microspheres exert synergistic antiglioma efficacy via inhibition of β-catenin transactivation. ( Chen, LY; Han, L; Kang, CS; Liu, CY; Pu, PY; Qian, XM; Shi, ZD; Yuan, XB; Zhang, JX; Zhang, KL, 2013) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 5.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| "There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting." | 5.01 | Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis. ( Ali-Osman, F; Amirian, ES; Amos, CI; Armstrong, GN; Barnholtz-Sloan, JS; Bernstein, JL; Bondy, ML; Claus, EB; Gu, X; Houlston, RS; Il'yasova, D; Jacobs, DI; Jalali, A; Jenkins, RB; Johansen, C; Lachance, DH; Lai, RK; Melin, B; Merrell, RT; Olson, SH; Ostrom, QT; Sadetzki, S; Scheurer, ME; Schildkraut, JM; Shete, S; Wrensch, MR, 2019) |
| "Clinically, high cyclooxygenase-2 expression in malignant glioma correlates well with poor prognosis and the use of aspirin is associated with a reduced risk of glioma." | 3.96 | Aspirin Induced Glioma Apoptosis through Noxa Upregulation. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Liao, SL; Ou, YC; Pan, PH; Wang, JD; Wang, WY, 2020) |
| "Few studies have examined the association between use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) and risk of glioma and the results have been equivocal." | 3.79 | Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study. ( Friis, S; Gaist, D; García-Rodríguez, LA; Hallas, J; Sørensen, HT, 2013) |
| "The aetiology of primary brain tumours is largely unknown; the role of non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin use and glioma risk has been inconclusive, but few population-based studies with reliable prescribing data have been conducted, and the association with meningioma risk has yet to be assessed." | 3.79 | Non-steroidal anti-inflammatory drug use and brain tumour risk: a case-control study within the Clinical Practice Research Datalink. ( Bannon, FJ; Cardwell, CR; Fleming, SJ; Gavin, AT; Hughes, CM; Murray, LJ; O'Rorke, MA, 2013) |
| " We studied the effect of various doses of ASA on the growth of C6 glioma implanted in rats as well as the effect of chronic administration of ASA on time of development and incidence of tumors of the central nervous system (CNS) induced by prenatal exposure to ethylnitrosourea (ENU)." | 3.71 | Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system. ( Arrieta, O; Guevara, P; Palencia, G; Reyes, S; Rivera, E; Sotelo, J, 2001) |
| " Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture." | 3.70 | Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 3.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| "When cultured malignant cells derived from rat gliomas (C6 and 9L) and human gliomas (A-172 and T98G) were treated for 4 hours with 1 to 80 microns nordihydroguaiaretic acid (NDGA) or 5,8,11,14-eicosatetraynoic acid (ETYA), a dose-dependent inhibition of deoxyribonucleic acid (DNA) synthesis occurred." | 3.67 | Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation. ( Anderson, KM; DiGianfilippo, A; Harris, JE; Ondrey, FG; Wilson, DE, 1989) |
| "Glioma and meningioma are uncommon tumors of the brain with few known risk factors." | 1.43 | Analgesic use and the risk of primary adult brain tumor. ( Anic, GA; Chowdhary, SA; Egan, KM; Forsyth, PA; LaRocca, RV; Nabors, LB; Olson, JJ; Rozmeski, CM; Thompson, RC; Thompson, ZJ, 2016) |
| "Aspirin treatment inhibited cell proliferation and caused early apoptosis in glioma, coupled with reduced S100A9 levels." | 1.39 | Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin. ( Chen, S; Cheng, Y; Deng, J; Huang, N; Huang, Q; Liao, P; Wang, F, 2013) |
| "Aspirin microsphere treatment induced slight apoptosis and modestly inhibited proliferation of LN229 and U87 cells in vitro and in vivo through inhibition of β-catenin transactivation." | 1.39 | Aspirin-/TMZ-coloaded microspheres exert synergistic antiglioma efficacy via inhibition of β-catenin transactivation. ( Chen, LY; Han, L; Kang, CS; Liu, CY; Pu, PY; Qian, XM; Shi, ZD; Yuan, XB; Zhang, JX; Zhang, KL, 2013) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 1.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CY | 1 |
| Pan, PH | 1 |
| Li, JR | 1 |
| Ou, YC | 1 |
| Wang, JD | 1 |
| Liao, SL | 1 |
| Chen, WY | 1 |
| Wang, WY | 1 |
| Chen, CJ | 1 |
| Ming, J | 1 |
| Sun, B | 1 |
| Li, Z | 1 |
| Lin, L | 1 |
| Meng, X | 1 |
| Han, B | 1 |
| Wang, R | 1 |
| Wu, P | 1 |
| Li, J | 1 |
| Cai, J | 1 |
| Jiang, C | 2 |
| Amirian, ES | 1 |
| Ostrom, QT | 1 |
| Armstrong, GN | 1 |
| Lai, RK | 1 |
| Gu, X | 1 |
| Jacobs, DI | 1 |
| Jalali, A | 1 |
| Claus, EB | 1 |
| Barnholtz-Sloan, JS | 1 |
| Il'yasova, D | 1 |
| Schildkraut, JM | 1 |
| Ali-Osman, F | 1 |
| Sadetzki, S | 1 |
| Jenkins, RB | 1 |
| Lachance, DH | 1 |
| Olson, SH | 1 |
| Bernstein, JL | 1 |
| Merrell, RT | 1 |
| Wrensch, MR | 1 |
| Johansen, C | 1 |
| Houlston, RS | 1 |
| Scheurer, ME | 1 |
| Shete, S | 1 |
| Amos, CI | 1 |
| Melin, B | 1 |
| Bondy, ML | 1 |
| Mihajluk, K | 1 |
| Simms, C | 1 |
| Reay, M | 1 |
| Madureira, PA | 1 |
| Howarth, A | 1 |
| Murray, P | 1 |
| Nasser, S | 1 |
| Duckworth, CA | 1 |
| Pritchard, DM | 1 |
| Pilkington, GJ | 1 |
| Hill, R | 1 |
| Mormile, R | 1 |
| Gaist, D | 1 |
| García-Rodríguez, LA | 1 |
| Sørensen, HT | 1 |
| Hallas, J | 1 |
| Friis, S | 1 |
| Bannon, FJ | 1 |
| O'Rorke, MA | 1 |
| Murray, LJ | 1 |
| Hughes, CM | 1 |
| Gavin, AT | 1 |
| Fleming, SJ | 1 |
| Cardwell, CR | 1 |
| Huang, N | 1 |
| Chen, S | 1 |
| Deng, J | 1 |
| Huang, Q | 1 |
| Liao, P | 1 |
| Wang, F | 1 |
| Cheng, Y | 1 |
| Egan, KM | 1 |
| Nabors, LB | 1 |
| Thompson, ZJ | 1 |
| Rozmeski, CM | 1 |
| Anic, GA | 1 |
| Olson, JJ | 1 |
| LaRocca, RV | 1 |
| Chowdhary, SA | 1 |
| Forsyth, PA | 1 |
| Thompson, RC | 1 |
| Fujita, M | 1 |
| Kohanbash, G | 1 |
| Fellows-Mayle, W | 1 |
| Hamilton, RL | 1 |
| Komohara, Y | 1 |
| Decker, SA | 1 |
| Ohlfest, JR | 1 |
| Okada, H | 1 |
| Chen, L | 1 |
| Huang, K | 1 |
| Han, L | 2 |
| Shi, Z | 1 |
| Zhang, K | 1 |
| Pu, P | 1 |
| Kang, C | 1 |
| Shi, ZD | 1 |
| Qian, XM | 1 |
| Liu, CY | 1 |
| Zhang, KL | 1 |
| Chen, LY | 1 |
| Zhang, JX | 1 |
| Pu, PY | 1 |
| Yuan, XB | 1 |
| Kang, CS | 1 |
| Hwang, SL | 1 |
| Lee, KS | 1 |
| Lin, CL | 1 |
| Lieu, AS | 1 |
| Cheng, CY | 1 |
| Loh, JK | 1 |
| Hwang, YF | 1 |
| Su, YF | 1 |
| Howng, SL | 1 |
| Aas, AT | 1 |
| Tønnessen, TI | 1 |
| Brun, A | 1 |
| Salford, LG | 1 |
| Casper, D | 1 |
| Lekhraj, R | 1 |
| Yaparpalvi, US | 1 |
| Pidel, A | 1 |
| Jaggernauth, WA | 1 |
| Werner, P | 1 |
| Tribius, S | 1 |
| Rowe, JD | 1 |
| LaSala, PA | 1 |
| Giese, A | 1 |
| Hagel, C | 1 |
| Kim, EL | 1 |
| Zapf, S | 1 |
| Djawaheri, J | 1 |
| Berens, ME | 1 |
| Westphal, M | 1 |
| Arrieta, O | 1 |
| Guevara, P | 1 |
| Reyes, S | 1 |
| Palencia, G | 1 |
| Rivera, E | 1 |
| Sotelo, J | 1 |
| Wilson, DE | 1 |
| DiGianfilippo, A | 1 |
| Ondrey, FG | 1 |
| Anderson, KM | 1 |
| Harris, JE | 1 |
1 review available for aspirin and Glial Cell Tumors
| Article | Year |
|---|---|
Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Case-Control Studies; Glioma; Hum | 2019 |
17 other studies available for aspirin and Glial Cell Tumors
| Article | Year |
|---|---|
Aspirin Induced Glioma Apoptosis through Noxa Upregulation.
Topics: Animals; Aspirin; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endoplasmic | 2020 |
Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Aspirin; Brain Neoplasms; Cell Line, Tumor; Dacarbazin | 2017 |
RETRACTED: IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Brain Neoplasms; Cell Hypoxia; Dru | 2019 |
Aspirin Use and Risk of Glioma: a Double Track for a Single Goal?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Glioma; Humans | 2020 |
Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; C | 2013 |
Non-steroidal anti-inflammatory drug use and brain tumour risk: a case-control study within the Clinical Practice Research Datalink.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Case-Control Studies | 2013 |
Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blotting, Western; Brain Neoplas | 2013 |
Analgesic use and the risk of primary adult brain tumor.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non | 2016 |
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.
Topics: Alleles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; CD8-Positive T-Lymphocytes; Cele | 2011 |
β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma.
Topics: Animals; Apoptosis; Aspirin; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Caten | 2011 |
Aspirin-/TMZ-coloaded microspheres exert synergistic antiglioma efficacy via inhibition of β-catenin transactivation.
Topics: Animals; Antineoplastic Agents, Alkylating; Aspirin; beta Catenin; Cell Line, Tumor; Dacarbazine; Dr | 2013 |
Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Dinoprostone; Dose-Response Relat | 2004 |
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; | 1995 |
Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture.
Topics: Acetaminophen; Adult; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Brain; Brain Neoplasms; Ce | 2000 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; | 1999 |
Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Carcinogens | 2001 |
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Cell Division; Cell Line; Cell Surviva | 1989 |