Compounds > aspirin
Page last updated: 2024-10-23

aspirin and Gingival Hemorrhage

aspirin has been researched along with Gingival Hemorrhage in 12 studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Gingival Hemorrhage: The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.

Research Excerpts

ExcerptRelevanceReference
"Aspirin can have an affect on BOP in naturally occurring gingivitis patients."9.12The effect of aspirin on gingival crevicular fluid levels of inflammatory and anti-inflammatory mediators in patients with gingivitis. ( Badovinac, RL; Hosokawa, I; Howell, TH; Karimbux, NY; Kawai, T; Kim, DM; Koszeghy, KL, 2007)
"Aspirin use has become increasingly common in the prevention of cerebrovascular and cardiovascular diseases."6.71The effect of aspirin intake on bleeding on probing in patients with gingivitis. ( Badovinac, RL; Fiorellini, J; Goodson, M; Howell, H; Karimbux, N; Recio, L; Royzman, D, 2004)
" The aim of this study was to evaluate the efficacy of systemic administration of omega-3 polyunsaturated fatty acids plus low-dose aspirin as an adjunctive treatment to regenerative therapy of furcation defects."5.15The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study). ( Elkhouli, AM, 2011)
"Aspirin can have an affect on BOP in naturally occurring gingivitis patients."5.12The effect of aspirin on gingival crevicular fluid levels of inflammatory and anti-inflammatory mediators in patients with gingivitis. ( Badovinac, RL; Hosokawa, I; Howell, TH; Karimbux, NY; Kawai, T; Kim, DM; Koszeghy, KL, 2007)
"Aspirin use has become increasingly common in the prevention of cerebrovascular and cardiovascular diseases."2.71The effect of aspirin intake on bleeding on probing in patients with gingivitis. ( Badovinac, RL; Fiorellini, J; Goodson, M; Howell, H; Karimbux, N; Recio, L; Royzman, D, 2004)
"The fatalistic attitude of hemophiliacs toward hepatitis is discussed, along with admonitions to avoid the use of aspirin, alcohol, and buttock injections."2.35Orthodontics and dentistry for the hemophilic patient. ( Grossman, RC, 1975)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's1 (8.33)18.2507
2000's4 (33.33)29.6817
2010's4 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shiloah, J1
Bland, PS1
Scarbecz, M1
Patters, MR1
Stein, SH1
Tipton, DA1
El-Sharkawy, H1
Aboelsaad, N1
Eliwa, M1
Darweesh, M1
Alshahat, M1
Kantarci, A1
Hasturk, H1
Van Dyke, TE1
Morimoto, Y1
Niwa, H1
Nakatani, T1
Elkhouli, AM1
Schrodi, J1
Recio, L2
Fiorellini, J2
Howell, H2
Goodson, M2
Karimbux, N2
Royzman, D1
Badovinac, RL2
Kim, DM1
Koszeghy, KL1
Kawai, T1
Hosokawa, I1
Howell, TH1
Karimbux, NY1
Elad, S1
Chackartchi, T1
Shapira, L1
Findler, M1
Flemmig, TF1
Epp, B1
Funkenhauser, Z1
Newman, MG1
Kornman, KS1
Haubitz, I1
Klaiber, B1
Foulke, CN1
Grossman, RC1
Reiff, RL1
White, CL1
Overman, P1
ElAttar, T1
Platt, RD1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial[NCT03093207]Phase 2/Phase 334 participants (Actual)Interventional2017-05-15Completed
Effects of Omega-3 Polyunsaturated Fatty Acids Daily Supplementation Plus Low-dose Aspirin as Adjunct to Full-mouth Periodontal Ultrasonic Debridement for the Treatment of Chronic Periodontitis in Type 2 Diabetics: Randomized Clinical Trial[NCT02800252]75 participants (Anticipated)Interventional2016-06-30Recruiting
Evaluation of Omega-3 Polyunsaturated Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Generalized Aggressive Periodontitis: Randomized Controlled Clinical Trial[NCT03093246]Phase 2/Phase 338 participants (Actual)Interventional2017-05-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Attachment Level at Baseline, 3 Months and 6 Months

Evaluate the difference between baseline and 6 months CAL measures. CAL: distance from bottom of sulcus/pocket to the cement-enamel junction (CEJ). The CEJ will be identified by careful probe on cervical area. (NCT03093207)
Timeframe: Baseline, 3 and 6 months

,
Interventionmm (Mean)
Baseline3 months6 months
Control Group5.294.734.97
Test Group5.54.644.64

Percentage of Sites With Bleeding on Probe at Baseline, 3 Months and 6 Months

Evaluate the difference between baseline and 6 months BoP measures. BoP: bleeding that is induced by gentle probing of the sulcus/pocket. (NCT03093207)
Timeframe: Baseline, 3 and 6 months

,
Interventionpercentage of sites with BoP (Number)
Baseline3 months6 months
Control Group10010064.7
Test Group10076.4764.7

Probing Depth at Baseline, 3 Months and 6 Months

Evaluate the difference between baseline and 6 months PB measures. PB: distance from the bottom of sulcus/pocket to gingival margin. (NCT03093207)
Timeframe: Baseline, 3 and 6 months

,
Interventionmm (Mean)
Baseline3 months6 months
Control Group5.143.763.94
Test Group5.174.084

Change in Bleeding on Probe

Evaluate the difference between baseline and 6 months BoP measures (NCT03093246)
Timeframe: Baseline, 3 and 6 months

,
Interventionpercentage of sites with BoP (Mean)
Baseline3 months6 months
Control Group54.1133.2731.77
Test Group44.5827.4126.17

Change in Clinical Attachment Level

Evaluate the difference between baseline and 6 months CAL measures. (NCT03093246)
Timeframe: Baseline, 3 and 6 months

,
Interventionmilimeters (Mean)
Baseline3 months6 months
Control Group3.943.583.59
Test Group4.013.653.64

Change in Probing Depth

Evaluate the difference between baseline and 6 months PD measures. (NCT03093246)
Timeframe: Baseline, 3 and 6 months

,
Interventionmilimeters (Mean)
Baseline3 months6 months
Control Group3.883.383.37
Test Group3.743.263.25

Reviews

1 review available for aspirin and Gingival Hemorrhage

ArticleYear
Orthodontics and dentistry for the hemophilic patient.
    American journal of orthodontics, 1975, Volume: 68, Issue:4

    Topics: Anesthesia, Dental; Aspirin; Blood Platelets; Buttocks; Factor VIII; Gingival Hemorrhage; Hemophilia

1975

Trials

7 trials available for aspirin and Gingival Hemorrhage

ArticleYear
The effect of long-term aspirin intake on the outcome of non-surgical periodontal therapy in smokers: a double-blind, randomized pilot study.
    Journal of periodontal research, 2014, Volume: 49, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Periodontitis; Dental Plaque

2014
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 Fatty acids and low-dose aspirin.
    Journal of periodontology, 2010, Volume: 81, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Per

2010
The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study).
    Journal of periodontal research, 2011, Volume: 46, Issue:2

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Transplantation;

2011
The effect of aspirin on the periodontal parameter bleeding on probing.
    Journal of periodontology, 2002, Volume: 73, Issue:8

    Topics: Adult; Analysis of Variance; Aspirin; Dental Plaque Index; Disease Progression; Double-Blind Method;

2002
The effect of aspirin intake on bleeding on probing in patients with gingivitis.
    Journal of periodontology, 2004, Volume: 75, Issue:5

    Topics: Adult; Age Factors; Aspirin; Confounding Factors, Epidemiologic; Dental Plaque Index; Female; Follow

2004
The effect of aspirin on gingival crevicular fluid levels of inflammatory and anti-inflammatory mediators in patients with gingivitis.
    Journal of periodontology, 2007, Volume: 78, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dental Plaque Index; Dinoprostone; Female;

2007
Adjunctive supragingival irrigation with acetylsalicylic acid in periodontal supportive therapy.
    Journal of clinical periodontology, 1995, Volume: 22, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemoprevention; Chemotherapy, Adjuva

1995

Other Studies

4 other studies available for aspirin and Gingival Hemorrhage

ArticleYear
On the use of prothrombin complex concentrate in patients with coagulopathy requiring tooth extraction.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2010, Volume: 110, Issue:6

    Topics: Adult; Aspirin; Blood Coagulation Factors; Blood Loss, Surgical; Cellulose, Oxidized; Contraindicati

2010
A critically severe gingival bleeding following non-surgical periodontal treatment in patients medicated with anti-platelet.
    Journal of clinical periodontology, 2008, Volume: 35, Issue:4

    Topics: Aspirin; Clopidogrel; Drug Combinations; Female; Gingival Hemorrhage; Humans; Middle Aged; Periodont

2008
Gingival hemorrhage related to aspirin ingestion. A case report.
    Journal of periodontology, 1976, Volume: 47, Issue:6

    Topics: Adult; Aspirin; Blood Platelets; Gingival Hemorrhage; Humans; Male; Oral Hemorrhage

1976
Aspirin, buffered aspirin, and effervescent buffer rinses in reducing gingival inflammation in patients with gingivitis and early periodontitis.
    Quintessence international (Berlin, Germany : 1985), 1988, Volume: 19, Issue:4

    Topics: Adult; Antacids; Aspirin; Buffers; Double-Blind Method; Female; Gingival Hemorrhage; Gingivitis; Hum

1988