aspirin has been researched along with Gastric Ulcer in 846 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " EC-ASA 325 mg in a secondary cardiovascular disease prevention population taking aspirin 325 mg daily for ≥3 months and at risk for ASA-associated gastric ulcers (GUs)." | 9.19 | PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: results of two 6-month, phase 3 studies. ( Cryer, BL; Eisen, GM; Fort, JG; Goldstein, JL; Lanas, A; Miller, AB; O'Connor, C; Scheiman, JM; Whellan, DJ; Zhang, Y, 2014) |
| "The efficacy of low-dose lansoprazole has not been established for the prevention of recurrent gastric or duodenal ulcers in those receiving long-term low-dose aspirin (LDA) for cardiovascular and cerebrovascular protection." | 9.15 | Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. ( Abe, S; Ashida, K; Chiba, T; Hiramatsu, N; Itabashi, T; Kanto, T; Matsui, S; Matsumoto, Y; Mizokami, Y; Sakaki, N; Shimada, K; Sugano, K; Uchiyama, S; Uemura, N, 2011) |
| "A lower incidence of gastric and duodenal ulcers was seen in celecoxib/aspirin-treated subjects (19%) vs." | 9.12 | The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor. ( Dodge, WE; Goldstein, JL; Lanza, FL; Lowry, SC; Schwartz, HI, 2006) |
| "Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration." | 9.08 | Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997) |
| "Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer." | 9.06 | The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. ( Abbey, DE; Kurata, JH, 1990) |
| "Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids." | 9.06 | Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. ( Calzada, R; Dhar, R; Jaszewski, R, 1989) |
| "Seventy-two patients with endoscopically proven gastric ulcers were entered into a prospective controlled trial to assess the efficacy of ranitidine and cimetidine in ulcer healing." | 9.05 | Ranitidine in the treatment of gastric ulceration. ( Bornman, PC; Gilinsky, NH; Girdwood, AH; Lucke, W; Marks, IN; Mee, AS; Tobias, P; Wright, JP, 1982) |
| "Little is known about healing or recurrence of aspirin-induced gastric ulcers if aspirin intake is continued." | 9.05 | Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin. A double-blind study with cimetidine and follow-up. ( Ivey, KJ; O'Laughlin, JC; Silvoso, GK, 1982) |
| "To determine the effectiveness of naproxen in the treatment of osteoarthritis of the knee joint, a double-blind cross-over study against placebo was carried out on 61 patients." | 9.04 | Double-blind study of Naproxen in osteoarthritis of the knee joint. ( Ito, T; Mori, E; Muroga, T; Nakajima, A; Tanaka, S, 1976) |
| "Aspirin and gastric ulcer interaction are used as an example to illustrate this concept, especially the narration of how disease affects drug efficacy." | 8.93 | Drug-disease interactions: narrative review of aspirin in gastric ulcer. ( Nwose, EU; Yee, KC, 2016) |
| "Prescribed in patients with a history of myocardial infarction, stroke, transient ischemic attack, coronary intervention or bypass surgery, aspirin is one of the medications most commonly used in the secondary prevention of cardiovascular diseases." | 8.90 | PA32540 for the secondary prevention of cardiovascular disease in patients at risk for aspirin-associated gastric ulcers. ( Adams, S; Duffy, D; Rooney, B; Whellan, DJ, 2014) |
| "In the prevalent-user design, there was no significant association between low-dose aspirin and gastric ulcer observed in both cohorts." | 8.12 | Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design. ( Brenner, H; Chen, LJ; Holleczek, B; Nguyen, TNM; Schöttker, B; Sha, S, 2022) |
| "Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits." | 7.91 | Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits. ( Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A, 2019) |
| " Rats were treated with either moringa leaves (10%) or moringa extract (300 mg/kg body weight) for 4 weeks then treated with a single dose of aspirin to induce gastric ulcer." | 7.91 | Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats. ( Mabrok, HB; Mohamed, MS, 2019) |
| " (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined." | 7.88 | The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior. ( Abd El-Ghffar, EA; Al-Sayed, E; Efferth, T; Eldahshan, OA; Shehata, SM, 2018) |
| " The aim of the study was to investigate gastroprotective effect of hot water extracts combination of those herbal against aspirin-induced gastric ulcer model in rats." | 7.83 | Gastroprotective Effect of Combination of Hot Water Extracts of Licorice (Glycyrrhiza glabra), Pulasari Stem Bark (Alyxia reinwardtii), and Sembung Leaf (Blumea balsamifera) Against Aspirin-Induced Gastric Ulcer Model Rats. ( Mutmainah, M; Nugroho, AE; Rahmawati, N; Susilowati, R; Wijayanti, A, 2016) |
| "The present work is an attempt to elucidate the antiulcer activity of indole-3-carbinol (I3C), which is one of the anticarcinogenic phytochemicals found in the vegetables of Cruciferae family such as broccoli and cauliflower, alone or in combination with omeprazole (OMP), a proton pump inhibitor, to diminish the effects of induced acute gastric ulcer by aspirin (ASA) in male albino rats." | 7.80 | Evaluation of antiulcer activity of indole-3-carbinol and/or omeprazole on aspirin-induced gastric ulcer in rats. ( Abd-Elmageid, SA; Alshailabi, EM; El-Shinnawy, NA, 2014) |
| " Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats." | 7.79 | Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. ( Agrawal, M; Madhur, G; Mishra, V; Narender, T; Onasanwo, SA; Palit, G; Pandey, HP; Rastogi, P, 2013) |
| "Gastric ulcers were induced by the serosal application of 100% acetic acid, and the areas of the ulcers were measured thereafter." | 7.79 | NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4(+)VEGFR1(+) cells to the ulcer granulation tissues. ( Ae, T; Amano, H; Eshima, K; Hosono, K; Ito, Y; Katada, C; Koizumi, W; Majima, M; Minamino, T; Ohno, T; Sato, T; Shibuya, M; Suzuki, T, 2013) |
| "Long-term administration of low-dose aspirin (LDA) is associated with a greater risk of adverse events, including gastroduodenal ulcers." | 7.79 | Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers. ( Funaki, Y; Iida, A; Ito, Y; Kasugai, K; Kawamura, N; Mizuno, M; Ogasawara, N; Sasaki, M, 2013) |
| " divaricata flower methanolic extract (TDFME) was screened for antiulcer activity versus aspirin and ethanol induced gastric ulcers at three doses--125, 250, and 500 mg/kg--orally using misoprostol as a standard." | 7.79 | Prostaglandin analogous and antioxidant activity mediated gastroprotective action of Tabernaemontana divaricata (L.) R. Br. flower methanolic extract against chemically induced gastric ulcers in rats. ( Afreen, A; Ali Khan, MS; Mat Jais, AM, 2013) |
| "The endoscopic characteristics of gastric ulcers in patients who were using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA) and were infected with Helicobacter pylori remain unclear." | 7.78 | Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin. ( Abe, T; Fukui, H; Hori, K; Kim, Y; Kondo, T; Matsumoto, T; Miwa, H; Okugawa, T; Oshima, T; Sakurai, J; Tanaka, J; Tomita, T; Toyoshima, F; Watari, J; Yamasaki, T; Yokoyama, S, 2012) |
| " The aim of this study was to assess the protective effects of NS (Nigella sativa) and NH (natural honey) on acetylsalicylic acid induced gastric ulcer in an experimental model with comparison to Cimetidine (CD)." | 7.77 | Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats. ( Ansari, N; Bakhshi, IM; Bukhari, MH; Khalil, J; Qamar, S; Qamar, Z; Zahid, M, 2011) |
| "Endoscopy reveals low-dose aspirin-induced gastroduodenal injuries in patients with cerebral infarction." | 7.76 | Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction. ( Kato, M; Nema, H, 2010) |
| " Optimal effective dose of PPSM (25 mg/kg) showed antiulcerogenic activity against acute gastric ulcers (GU) induced by pylorus ligation and aspirin and duodenal ulcer induced by cysteamine but not against ethanol-induced GU." | 7.75 | Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats. ( Agarwal, PK; Dorababu, M; Goel, RK; Goel, S; Joshi, VK; Prabha, T; Singh, A, 2009) |
| "The involvement of nitric oxide in the gastroprotective effect of ACEA (arachidonyl-2-chloroethylamide), a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration was studied in rats." | 7.75 | Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. ( Fereniec-Gołebiewska, L; Rutkowska, M, 2009) |
| "Gastric ulcers were induced with acetic acid in rats; aspirin was administrated by gavage from day 25 to day 54 after ulcer induction." | 7.74 | Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. ( Guo, CJ; Huang, GP; Jia, BB; Wang, GZ; Wang, JF; Xie, CG; Yin, GL; Zhou, G, 2007) |
| "Gastroduodenal ulcers are found in one in 10 patients taking low-dose aspirin, and most are asymptomatic; this needs considering when discussing risks/benefits with patients." | 7.73 | Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. ( Appelman-Eszczuk, S; Daneshjoo, R; Eriksson, B; Hawkey, CJ; Lanas, AI; Långström, G; Naesdal, J; Serrano, P; Singh, M; Skelly, MM; Talley, NJ; Thomson, AB; Yeomans, ND, 2005) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 7.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| "Based on our previous studies that aspirin (ASA) -induced gastric ulceration in rats can be significantly reduced if the drug is chemically associated with phosphatidylcholine (PC), we undertook the present study to compare gastric ulcer healing rates in rats administered either unmodified or PC-complexed ASA." | 7.70 | Phosphatidylcholine-associated aspirin accelerates healing of gastric ulcers in rats. ( Kurinets, A; Lichtenberger, LM, 1998) |
| "The anti-ulcer effects of nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester] were examined on water-immersion plus restraint stress-induced and aspirin-induced gastric ulcers in rats, compared with those of cimetidine." | 7.70 | Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. ( Akima, M; Katsuyama, I; Sakai, K, 1999) |
| "We have examined the protective effect of liquorice or its derivatives against gastric ulcer induced by aspirin." | 7.69 | The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats. ( Dehpour, AR; Samadian, T; Vahedi, Y; Zolfaghari, ME, 1994) |
| "The effect of cromakalim, a potassium-channel opener, was studied on pylorus ligation-induced, aspirin-induced and water-immersion plus restraint stress-induced gastric ulcers in rats and on histamine-induced duodenal ulcer in guinea-pigs." | 7.69 | Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs. ( Goswami, S; Jain, S; Santani, D, 1997) |
| "A double-blind study was conducted to compare gastric ulcer healing time in nontreated dogs with that in dogs treated with either cimetidine or omeprazole." | 7.68 | Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs. ( Bright, RM; DeNovo, RC; Jenkins, CC; Patton, CS; Rohrbach, BW, 1991) |
| "The effect of verapamil, a calcium channel blocker, was studied against stress (cold restraint), aspirin and pylorus ligation induced gastric ulcers in rats." | 7.68 | Protection against gastric ulcer by verapamil. ( Dhawan, KN; Gupta, GP; Gupta, MB; Nath, C; Sinha, JN; Srivastava, SK; Vrat, S, 1991) |
| "Piracetam, used clinically for cognitive disorders, was found to have significant anti-ulcerogenic activity against immobilization stress- and aspirin-induced gastric ulcers in rats." | 7.68 | Effect of piracetam, a nootropic agent, on experimental gastric ulcers in rat. ( Abbas, WR; Bhattacharya, SK; Chakravarty, M; Goel, RK; Singh, KP, 1990) |
| "The effect of bromocriptine, a dopamine receptor agonist, has been studied on the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats." | 7.67 | Effect of bromocriptine, a dopamine receptor agonist, on the experimentally induced gastric ulcers in albino rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1984) |
| " Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole." | 7.67 | Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984) |
| "The effect of domperidone, a peripheral dopamine receptor antagonist, has been studied in the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats." | 7.67 | Effect of domperidone on experimentally induced gastric ulcers in rats. ( Ageel, AM; Al-Khamis, KI; Parmar, NS; Tariq, M, 1986) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 7.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| "Gastric ulcers were produced in conscious cats in 3 hr by simultaneous intravenous or intragastric administration of acetylsalicylic acid (ASA), plus intravenous infusion of histamine (80 micrograms/kg/hr), pentagastrin (8 micrograms/kg/hr), or intragastric instillation of HCl." | 7.66 | Aspirin-induced gastric ulcers in cats. Prevention by prostacyclin. ( Brzozowski, T; Dembińska-Kieć, A; Konturek, SJ; Piastucki, I; Radecki, T; Zmuda, A, 1981) |
| "To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findings." | 7.66 | Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats. ( Kitaura, T; Kunita, T; Miyoshi, A; Ohe, K; Yokoya, H, 1980) |
| "Antiulcer effects of geranylgeranylacetone (GGA) on aspirin-induced gastric ulcers in rats were studied, comparing them with those of gefarnate." | 7.66 | Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats. ( Fujisaki, H; Murakami, M; Ohgo, T; Okabe, S; Oketani, K; Wakabayashi, T, 1982) |
| "In unanesthetized cats, continuous intravenous infusion of aspirin for 36 hr did not produce gastric ulcers when given alone but did when combined with 160 microgram kg-1 hr-1 of histamine-2HCl intravenously." | 7.66 | Histamine augments gastric ulceration produced by intravenous aspirin in cats. ( Aures, D; Grossman, MI; Hansen, DG, 1978) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 7.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy." | 7.65 | Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. ( Clifton, JA; Ivey, KJ, 1974) |
| "Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa." | 5.51 | Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. ( Abd El-Ghffar, EA; Mahmoud, YI, 2019) |
| "There are many available drugs for treating gastric ulcer, but they have various side effects." | 5.42 | The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies. ( Salah Khalil, M, 2015) |
| "The aetiology of gastric ulcers is not completely understood and continuous use of anti-ulcer agents leads to many side effects." | 5.36 | Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats. ( Arjuman, A; Bhargavan, D; Chatterji, D; Dorababu, P; Gopalakrishna, HN; Mirshad, PV; Nair, V, 2010) |
| "The combination of hemorrhagic shock, aspirin, and acid caused pronounced mucosal lesions, whereas only minor lesions were seen with aspirin and acid alone." | 5.27 | Canine gastric ulcer produced by hemorrhagic shock and aspirin. ( Amdrup, E; Casalnuovo, CA; Kraglund, K; Kristensen, IB, 1984) |
| "Aspirin is a known gastric mucosal barrier breaker and it produces a significant increase of the ulcer index in the restraint rat model." | 5.27 | The effect of 3-methoxy-5,7,3',4'-tetrahydroxyflavan on the restraint induced gastric ulceration augmented by aspirin, a gastric mucosal barrier breaker. ( Hennings, G; Parmar, NS, 1983) |
| " Three weeks later these rats were orally dosed each day with aspirin (375 mg/kg) for six months." | 5.27 | Molecular weight of gastric mucus glycoprotein is a determinant of the degree of subsequent aspirin induced chronic gastric ulceration in the rat. ( Bagshaw, PF; Munster, DJ; Wilson, JG, 1987) |
| "Benzydamine (Tantum) was studied for ulcerogenic and ulcer protective effects in the rat gastric mucosa." | 5.27 | [Experimental findings on gastric ulcerogenicity and mucosa protection by benzydamine in the rat]. ( Hell, I, 1987) |
| " EC-ASA 325 mg in a secondary cardiovascular disease prevention population taking aspirin 325 mg daily for ≥3 months and at risk for ASA-associated gastric ulcers (GUs)." | 5.19 | PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: results of two 6-month, phase 3 studies. ( Cryer, BL; Eisen, GM; Fort, JG; Goldstein, JL; Lanas, A; Miller, AB; O'Connor, C; Scheiman, JM; Whellan, DJ; Zhang, Y, 2014) |
| "The rate of gastric ulcers in subjects receiving paracetamol (0/21, 0%) alone or aspirin (3/19, 16%) or both (2/20, 10%) was not different." | 5.16 | Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study. ( Berkes, J; Boike, JR; Goldstein, JL; Kao, R; Markle, B; Meyer, D; Niebruegge, J; Rosenberg, J; Stein, AC, 2012) |
| "The efficacy of low-dose lansoprazole has not been established for the prevention of recurrent gastric or duodenal ulcers in those receiving long-term low-dose aspirin (LDA) for cardiovascular and cerebrovascular protection." | 5.15 | Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. ( Abe, S; Ashida, K; Chiba, T; Hiramatsu, N; Itabashi, T; Kanto, T; Matsui, S; Matsumoto, Y; Mizokami, Y; Sakaki, N; Shimada, K; Sugano, K; Uchiyama, S; Uemura, N, 2011) |
| "To determine the rate of endoscopic gastric/duodenal ulcers (GDUs) associated with use of aspirin (81 mg q." | 5.13 | Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial. ( Aisenberg, J; Berger, MF; Dodge, WE; Goldstein, JL; Zakko, SF, 2008) |
| "A lower incidence of gastric and duodenal ulcers was seen in celecoxib/aspirin-treated subjects (19%) vs." | 5.12 | The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor. ( Dodge, WE; Goldstein, JL; Lanza, FL; Lowry, SC; Schwartz, HI, 2006) |
| "Subjects 18 years or older with osteoarthritis, without gastroduodenal ulcer or erosive esophagitis at baseline endoscopy, and a cardiovascular indication for prophylaxis low-dose (81 or 325 mg) aspirin were prescribed open-label aspirin and blindly randomized to celecoxib 200 mg/day or naproxen 500 mg twice daily plus lansoprazole 30 mg once daily." | 5.12 | Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. ( Amer, F; Cryer, B; Goldstein, JL; Hunt, B, 2007) |
| "Osteoarthritis patients > or =50 years of age without ulcers or erosive esophagitis at baseline endoscopy were assigned randomly to placebo, enteric-coated aspirin 81 mg/day, rofecoxib 25 mg combined with aspirin 81 mg/day, or ibuprofen 800 mg 3 times a day." | 5.11 | Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial. ( Laine, L; Maller, ES; Quan, H; Simon, T; Yu, C, 2004) |
| "This analysis compared the efficacy of misoprostol, lansoprazole, and placebo in reducing the risk of gastric or duodenal ulcer recurrence in patients taking NSAIDs and low-dose aspirin." | 5.11 | Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. ( Amer, F; Christopoulos, NG; Goldstein, JL; Huang, B, 2004) |
| " Gastric ulcers developed in five out of 26 subjects given ASA, two out of 25 given alendronate, and none of 25 given placebo." | 5.09 | A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract. ( Hunt, RH; James, C; Marshall, JK; Rainsford, KD, 2000) |
| "Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration." | 5.08 | Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration. ( Brough, JL; Filipowicz, B; Hawkey, CJ; Hull, MA; Knifton, A; Vautier, G, 1997) |
| " In the upper GI endoscopy study, 19% of subjects receiving naproxen (6 of 32) developed gastric ulcers, whereas no ulcers occurred in subjects receiving SC-58635 or placebo." | 5.08 | Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. ( Geis, GS; Hubbard, RC; Isakson, PC; Lanza, FL; Lipsky, PE; Schwartz, BD; Simon, LS; Talwalker, S, 1998) |
| "Three randomized, placebo-controlled multiclinic trials involving arbaprostil dosages of (a) 10 micrograms; (b) 25 micrograms; and (c) 10, 25, or 50 micrograms orally for 4 wk in patients older than 18 yr with rheumatoid arthritis or osteoarthritis who had endoscopically documented nonsteroidal antiinflammatory drug-associated gastric mucosal damage were conducted in the United States." | 5.06 | A report of three multiclinic trials evaluating arbaprostil in arthritic patients with ASA/NSAID gastric mucosal damage. The Upjohn Company Arbaprostil ASA/NSAID Gastric Mucosal Damage Treatment Study Groups. ( Champion, C; Euler, AR; Fleischmann, R; Jaszewski, R; Le, V; Rao, J; Raskin, J; Razzaque, M; Safdi, M; Welsh, J, 1990) |
| "Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer." | 5.06 | The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations. ( Abbey, DE; Kurata, JH, 1990) |
| "Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids." | 5.06 | Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. ( Calzada, R; Dhar, R; Jaszewski, R, 1989) |
| "Seventy-two patients with endoscopically proven gastric ulcers were entered into a prospective controlled trial to assess the efficacy of ranitidine and cimetidine in ulcer healing." | 5.05 | Ranitidine in the treatment of gastric ulceration. ( Bornman, PC; Gilinsky, NH; Girdwood, AH; Lucke, W; Marks, IN; Mee, AS; Tobias, P; Wright, JP, 1982) |
| "Little is known about healing or recurrence of aspirin-induced gastric ulcers if aspirin intake is continued." | 5.05 | Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin. A double-blind study with cimetidine and follow-up. ( Ivey, KJ; O'Laughlin, JC; Silvoso, GK, 1982) |
| "To determine the effectiveness of naproxen in the treatment of osteoarthritis of the knee joint, a double-blind cross-over study against placebo was carried out on 61 patients." | 5.04 | Double-blind study of Naproxen in osteoarthritis of the knee joint. ( Ito, T; Mori, E; Muroga, T; Nakajima, A; Tanaka, S, 1976) |
| "Aspirin and gastric ulcer interaction are used as an example to illustrate this concept, especially the narration of how disease affects drug efficacy." | 4.93 | Drug-disease interactions: narrative review of aspirin in gastric ulcer. ( Nwose, EU; Yee, KC, 2016) |
| "Aspirin, even at low doses, has been known to cause upper gastro-intestinal complications, such as gastroduodenal ulcers, despite the definite benefits from its antithrombotic effects." | 4.91 | Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury. ( Iijima, K; Shimosegawa, T, 2015) |
| "Prescribed in patients with a history of myocardial infarction, stroke, transient ischemic attack, coronary intervention or bypass surgery, aspirin is one of the medications most commonly used in the secondary prevention of cardiovascular diseases." | 4.90 | PA32540 for the secondary prevention of cardiovascular disease in patients at risk for aspirin-associated gastric ulcers. ( Adams, S; Duffy, D; Rooney, B; Whellan, DJ, 2014) |
| "Along with the growing elderly population, patients with gastric ulcers caused by low-dose aspirin have increased." | 4.86 | [Differential diagnosis of gastric ulcer and gastric cancer in elderly patients]. ( Akamatsu, T; Arakura, N; Ito, T; Iwaya, Y; Nagaya, T; Suga, T, 2010) |
| " In clinical trials, PPI and famotidine (40 mg/d) are proven to have the preventive effect to gastric ulceration induced by low-dose aspirin use." | 4.86 | [Mucoprotective drugs and aspirin-induced gastric injury]. ( Sugiyama, T; Yamawaki, H, 2010) |
| "Based on current references four clinical scenarios were discussed and different management strategies were compared for secondary and primary prophylaxis of ulcer or peptic ulcer bleeding under continuous therapy with non-steroidal antiinflammatory drugs (NSAID) or low-dose-aspirin, for H." | 4.82 | [Secondary and primary prophylaxis of gastropathy associated with nonsteroidal antiinflammatory drugs or low-dose-aspirin: a review based on four clinical scenarios]. ( Ittel, TH; Limmer, S; Wietholtz, H, 2003) |
| "Although figures vary considerably, the ingestion of aspirin or other non-aspirin non-steroidal anti-inflammatory drugs is associated with an increased risk of gastric ulceration, ulcer bleeding, ulcer complications and of death by a factor of around 3." | 4.79 | Nonsteroidal anti-inflammatory drug-induced gastric damage: epidemiology. ( Langman, MJ; Shorrock, CJ, 1995) |
| " Epidermal growth factor prevents efficiently the experimentally induced acute gastric mucosal lesions induced by aspirin, absolute ethanol, HCl, NaCl, immobilization, and immersion and it accelerates the healing of acetic acid-induced chronic gastric and cysteamine-induced chronic duodenal ulcers." | 4.79 | [Growth factors in experimental ulcer]. ( Buzás, G, 1994) |
| "A substantial body of studies (controlled, cohort and case-control studies) now confirm the long established impression that there is an increased prevalence of gastric and duodenal ulcer and of associated complications in subjects treated with aspirin (ASA) or with non-steroidal anti-inflammatory drugs (NSAIDs)." | 4.79 | [The epidemiology of the gastroduodenal damage induced by aspirin and other nonsteroidal anti-inflammatory drugs]. ( Benvenuti, S; de Guelmi, A; Dobrilla, G, 1997) |
| " Aspirin and all nonsalicylate NSAIDs share a risk of causing gastric ulcer, upper GI bleeding, and GI perforation." | 4.78 | Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis. A review and suggestions. ( Greene, JM; Winickoff, RN, 1992) |
| " The pathogenesis of aspirin-induced gastric ulceration includes blocking the activities of the cyclooxygenase enzymes (COX-1 and COX-2) leading to reduced mucus and bicarbonate secretion." | 4.12 | Spirulina supplements: an approach moderating aspirin persuaded histological and ultra-structural alterations in albino rats gastric mucosa. ( Bayoumi, AH; Kamar, SA; Rady, HY, 2022) |
| "In the prevalent-user design, there was no significant association between low-dose aspirin and gastric ulcer observed in both cohorts." | 4.12 | Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design. ( Brenner, H; Chen, LJ; Holleczek, B; Nguyen, TNM; Schöttker, B; Sha, S, 2022) |
| " Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively." | 4.12 | Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models. ( Ahsan, H; Anjum, I; Ismail, S; Kahrizi, D; Movafagh, A; Naveed Mushtaq, M; Ramzan, HM; Razzaq, A; Shabbir, U; Shoukat, A, 2022) |
| " Chronic gastric ulcer in rats was modeled using glacial acetic acid." | 3.96 | A new derivative of acetylsalicylic acid and carnosine: synthesis, physical and chemical properties, biological activity. ( Andreeva, LA; Fedorova, TN; Kulichenkova, KN; Kulikova, OI; Lopachev, AV; Lopacheva, OM; Migulin, VA; Nagaev, IY; Stvolinsky, SL; Trubitsina, IE, 2020) |
| "Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits." | 3.91 | Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits. ( Ahmad, M; Aslam, B; Mohsin, M; Muhammad, F; Raza, A, 2019) |
| " Rats were treated with either moringa leaves (10%) or moringa extract (300 mg/kg body weight) for 4 weeks then treated with a single dose of aspirin to induce gastric ulcer." | 3.91 | Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats. ( Mabrok, HB; Mohamed, MS, 2019) |
| "Aspirin combination is prescribed for its thrombolytic activity where gastric ulceration is the major side effect of aspirin which can be prevented by combining it with proton pump inhibitor omeprazole." | 3.88 | Stability Indicating Liquid Chromatographic Method for Simultaneous Determination of Aspirin and Omeprazole. ( Patel, AD; Patel, VB; Shah, DA, 2018) |
| "Artesunate markedly ameliorated aspirin induced gastric injury in rats by targeting oxidative stress and COX-2 dependent as well as COX-2 independent proinflammatory signaling pathways and could have a therapeutic potential in gastric ulcer disease." | 3.88 | Artesunate affords protection against aspirin-induced gastric injury by targeting oxidative stress and proinflammatory signaling. ( Kumar, VL; Verma, S, 2018) |
| " (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined." | 3.88 | The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior. ( Abd El-Ghffar, EA; Al-Sayed, E; Efferth, T; Eldahshan, OA; Shehata, SM, 2018) |
| " subterranea (EEVS) was investigated for its gastroprotective effects on aspirin plus pylorus ligation-induced gastric ulcerated rats using an in vivo assay." | 3.88 | Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury. ( Balogun, ME; Besong, EE; Djobissie, FSA; Mbamalu, OS; Obimma, JN, 2018) |
| " The aim of the study was to investigate gastroprotective effect of hot water extracts combination of those herbal against aspirin-induced gastric ulcer model in rats." | 3.83 | Gastroprotective Effect of Combination of Hot Water Extracts of Licorice (Glycyrrhiza glabra), Pulasari Stem Bark (Alyxia reinwardtii), and Sembung Leaf (Blumea balsamifera) Against Aspirin-Induced Gastric Ulcer Model Rats. ( Mutmainah, M; Nugroho, AE; Rahmawati, N; Susilowati, R; Wijayanti, A, 2016) |
| " rotundus rhizome methanolic extract (CME; 250 mg/kg and 500 mg/kg) significantly inhibited aspirin-induced gastric ulceration in animals in a dose-dependent manner (49." | 3.81 | Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress. ( Baiju, EC; Govindhan, S; Kunnumakkara, AB; Padikkala, J; Padmavathi, G; Thomas, D, 2015) |
| " Aspirin 150 mg/kg was used to induce gastric ulcer in all groups except normal control." | 3.81 | Histopathological evaluation of gastro protective effect of Berberis vulgaris (Zereshk) seeds against aspirin induced ulcer in albino mice. ( Ali, A; Aslam, B; Javed, I; Khaliq, T; Majeed, W; Muhammad, F; Raza, A, 2015) |
| " The in vivo studies on albino mice proved the purified fraction has anti-stress/anti-allergic activity against milk induced leucocytosis/eosinophilia and able to inhibit the aspirin induced gastric ulcers." | 3.80 | In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br. ( Annamalai, SK; Arun, LB; Arunachalam, AM; Arunachalam, KD; Kumar, KA, 2014) |
| "The present work is an attempt to elucidate the antiulcer activity of indole-3-carbinol (I3C), which is one of the anticarcinogenic phytochemicals found in the vegetables of Cruciferae family such as broccoli and cauliflower, alone or in combination with omeprazole (OMP), a proton pump inhibitor, to diminish the effects of induced acute gastric ulcer by aspirin (ASA) in male albino rats." | 3.80 | Evaluation of antiulcer activity of indole-3-carbinol and/or omeprazole on aspirin-induced gastric ulcer in rats. ( Abd-Elmageid, SA; Alshailabi, EM; El-Shinnawy, NA, 2014) |
| " Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats." | 3.79 | Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. ( Agrawal, M; Madhur, G; Mishra, V; Narender, T; Onasanwo, SA; Palit, G; Pandey, HP; Rastogi, P, 2013) |
| "The gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against experimental gastric ulcer and study its effect on the content of nitric oxide (NO) and epidermal growth factor (EGF), gastric mucosal blood flow, the content of PGE2, gastric secretion, gastric acid content and the activity of pepsin." | 3.79 | [Study on efficacy and mechanism of weiyangning pills against experimental gastric ulcer]. ( Cao, HY; Huang, P; Liu, J; Wen, S; Wu, QH; Xu, JJ, 2013) |
| "Gastric ulcers were induced by the serosal application of 100% acetic acid, and the areas of the ulcers were measured thereafter." | 3.79 | NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4(+)VEGFR1(+) cells to the ulcer granulation tissues. ( Ae, T; Amano, H; Eshima, K; Hosono, K; Ito, Y; Katada, C; Koizumi, W; Majima, M; Minamino, T; Ohno, T; Sato, T; Shibuya, M; Suzuki, T, 2013) |
| " Peganine hydrochloride was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats." | 3.79 | Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. ( Barthwal, MK; Khaliq, T; Mishra, V; Narender, T; Palit, G; Pandey, HP; Singh, VK; Tiwari, S, 2013) |
| "Long-term administration of low-dose aspirin (LDA) is associated with a greater risk of adverse events, including gastroduodenal ulcers." | 3.79 | Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers. ( Funaki, Y; Iida, A; Ito, Y; Kasugai, K; Kawamura, N; Mizuno, M; Ogasawara, N; Sasaki, M, 2013) |
| " divaricata flower methanolic extract (TDFME) was screened for antiulcer activity versus aspirin and ethanol induced gastric ulcers at three doses--125, 250, and 500 mg/kg--orally using misoprostol as a standard." | 3.79 | Prostaglandin analogous and antioxidant activity mediated gastroprotective action of Tabernaemontana divaricata (L.) R. Br. flower methanolic extract against chemically induced gastric ulcers in rats. ( Afreen, A; Ali Khan, MS; Mat Jais, AM, 2013) |
| "The gastroprotective activity of EPF was evaluated on four gastric-ulcer models such as pyloric ligation (PL), ethanol (EtOH), cold restrain stress (CRS) and aspirin (ASP)-induced gastric ulcers." | 3.79 | Gastroprotective activity of ethanolic root extract of Potentilla fulgens Wall. ex Hook. ( Hemalatha, S; Krishnamurthy, S; Laloo, D; Prasad, SK, 2013) |
| "The endoscopic characteristics of gastric ulcers in patients who were using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA) and were infected with Helicobacter pylori remain unclear." | 3.78 | Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin. ( Abe, T; Fukui, H; Hori, K; Kim, Y; Kondo, T; Matsumoto, T; Miwa, H; Okugawa, T; Oshima, T; Sakurai, J; Tanaka, J; Tomita, T; Toyoshima, F; Watari, J; Yamasaki, T; Yokoyama, S, 2012) |
| "The incidence of postoperative definitive gastric ulcers in Japanese patients receiving ≤100 mg enteric-coated aspirin was 0." | 3.78 | Gastric injury caused by low-dose aspirin therapy in consecutive Japanese patients: a prospective study. ( Akita, S; Akiyama, J; Fukuda, S; Hosaka, S; Kashima, T; Kimura, S; Mizoue, T; Ozawa, N, 2012) |
| "Gastric ulcers and related complications associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, represent a major global health problem." | 3.77 | Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats. ( Raghavendran, HR; Rekha, S; Srinivasan, P, 2011) |
| "Advanced age, atherosclerosis, male gender and NSAID administration (particularly aspirin) are the major risk factors of upper GI hemorrhage in patients with gastric and/or duodenal ulcer." | 3.77 | Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. ( Akkız, H; Coşar, A; Ozdil, B; Sandıkçı, M, 2011) |
| " Anti-ulcer activity was evaluated against cold restraint (CRU), pyloric ligation (PL), aspirin (ASP), alcohol (AL) induced gastric ulcer and histamine (HA) induced duodenal ulcer model and further confirmed through in vitro assay of H(+) K(+)-ATPase activity and plasma gastrin level." | 3.77 | Anti-ulcer constituents of Annona squamosa twigs. ( Dev, K; Maurya, R; Palit, G; Sahai, M; Sharma, R; Singh, N; Yadav, DK, 2011) |
| "The aim of this study was to determine the antiulcer and antioxidant activities of Centaurium erythraea L (small centaury) in aspirin (ASA) induced acute gastric ulcer model." | 3.77 | Gastroprotective effect of small centaury (Centaurium erythraea L) on aspirin-induced gastric damage in rats. ( Ine, H; Koyuncu, I; Ozkol, H; Tuluce, Y, 2011) |
| " The aim of this study was to assess the protective effects of NS (Nigella sativa) and NH (natural honey) on acetylsalicylic acid induced gastric ulcer in an experimental model with comparison to Cimetidine (CD)." | 3.77 | Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats. ( Ansari, N; Bakhshi, IM; Bukhari, MH; Khalil, J; Qamar, S; Qamar, Z; Zahid, M, 2011) |
| "Effect of various doses (20, 40, 80, 160 and 320 mg/kg, po) of earthworm paste (Lampito mauritii, Kinberg) was studied on aspirin-induced gastric ulcer and compared to ranitidine." | 3.76 | Gastroprotective effect of earthworm paste (Lampito mauritii, Kinberg) on experimental gastric ulcer in rats. ( Gunasekaran, G; Prakash, M, 2010) |
| "The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs." | 3.76 | Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action. ( Kaithwas, G; Majumdar, DK, 2010) |
| "Endoscopy reveals low-dose aspirin-induced gastroduodenal injuries in patients with cerebral infarction." | 3.76 | Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction. ( Kato, M; Nema, H, 2010) |
| " Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13." | 3.75 | Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009) |
| " The analgesic activity of the test compounds was determined by phenylbenzoquinone-induced writhing assay and the anti-inflammatory activity was evaluated by the carrageenan-induced rat paw edema model." | 3.75 | Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives. ( Colak, MS; Gökçe, M; Küpeli, E; Sahin, MF, 2009) |
| " Optimal effective dose of PPSM (25 mg/kg) showed antiulcerogenic activity against acute gastric ulcers (GU) induced by pylorus ligation and aspirin and duodenal ulcer induced by cysteamine but not against ethanol-induced GU." | 3.75 | Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats. ( Agarwal, PK; Dorababu, M; Goel, RK; Goel, S; Joshi, VK; Prabha, T; Singh, A, 2009) |
| "The involvement of nitric oxide in the gastroprotective effect of ACEA (arachidonyl-2-chloroethylamide), a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration was studied in rats." | 3.75 | Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. ( Fereniec-Gołebiewska, L; Rutkowska, M, 2009) |
| "The present study investigate the effect of ascorbic acid, the major bioactive component isolated from Cissus quadrangularis extract (CAA) on inflammatory cytokines and growth factors in non-steroidal anti-inflammatory drug (NSAID) induced gastric ulcer." | 3.74 | Protective role of ascorbic acid isolated from Cissus quadrangularis on NSAID induced toxicity through immunomodulating response and growth factors expression. ( Jainu, M; Mohan, KV, 2008) |
| "The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats." | 3.74 | Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). ( Gopalakrishnan, G; Kavimani, S; Malairajan, P; Narasimhan, S; Veni, KJ, 2007) |
| " potatorum Linn seeds on aspirin plus pyloric ligation (Aspirin+PL)-induced gastric ulcer model to substantiate its folklore claim." | 3.74 | Antiulcerogenic potential of Strychnos potatorum Linn seeds on aspirin plus pyloric ligation-induced ulcers in experimental rats. ( Sanmugapriya, E; Venkataraman, S, 2007) |
| "Rodent models were employed to investigate the effects of combinations of celecoxib and aspirin on gastric ulcerogenesis, bleeding, surface hydrophobicity (by contact angle analysis) and ulcer healing." | 3.74 | Surface phospholipids in gastric injury and protection when a selective cyclooxygenase-2 inhibitor (Coxib) is used in combination with aspirin. ( Dial, EJ; Lichtenberger, LM; Romero, JJ, 2007) |
| "Gastric ulcers were induced with acetic acid in rats; aspirin was administrated by gavage from day 25 to day 54 after ulcer induction." | 3.74 | Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. ( Guo, CJ; Huang, GP; Jia, BB; Wang, GZ; Wang, JF; Xie, CG; Yin, GL; Zhou, G, 2007) |
| "41 in aspirin- and ethanol-induced gastric ulceration, respectively." | 3.73 | The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract. ( Ajaikumar, KB; Asheef, M; Babu, BH; Padikkala, J, 2005) |
| " The extract at 400 mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2 h cold restraint stress), aspirin (ASA, 150 mg/kg body weight, orally), alcohol (AL, 1 ml/200 gm of absolute alcohol) and pyloric ligation (PL, 4h ligation) induced gastric ulcer models as it showed protection index of 71." | 3.73 | Allophylus serratus: a plant with potential anti-ulcerogenic activity. ( Dharmani, P; Maurya, R; Mishra, PK; Palit, G; Singh Chauhan, V, 2005) |
| " albicans and vehicle inoculation on gastric secretion and healing of gastric ulcers induced by acetic acid in rats treated with 1) ranitidine (30 mg kg(-1) day(-1) s." | 3.73 | Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy. ( Bogdal, J; Brzozowski, T; Budak, A; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Pawlik, WW; Stachura, J; Zwolinska-Wcislo, M, 2005) |
| "The present study was designed to investigate anti-ulcerogenic property of ethanolic extract of Desmodium gangeticum (DG) against cold restraint (CRU, 2 hr cold restraint stress), aspirin (ASP, 150 mg/kg orally), alcohol (AL, absolute alcohol 1 ml/200gm) and pyloric ligation (PL, 4 hr pylorus ligation) induced gastric ulcer models in Sprague Dawley rats, and histamine (HST, 0." | 3.73 | Desmodium gangeticum: a potent anti-ulcer agent. ( Chauhan, VS; Dharmani, P; Maurya, R; Mishra, PK; Palit, G, 2005) |
| "Gastroduodenal ulcers are found in one in 10 patients taking low-dose aspirin, and most are asymptomatic; this needs considering when discussing risks/benefits with patients." | 3.73 | Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. ( Appelman-Eszczuk, S; Daneshjoo, R; Eriksson, B; Hawkey, CJ; Lanas, AI; Långström, G; Naesdal, J; Serrano, P; Singh, M; Skelly, MM; Talley, NJ; Thomson, AB; Yeomans, ND, 2005) |
| " Gaultherin, 2-[(6-O-beta-D-Xylopyranosyl-beta-D-glucopyranosyl)oxy] benzoic acid methyl ester, a natural salicylate derivative extracted from Gaultheria yunnanensis, has been shown to have analgesic and anti-inflammatory effects and lack gastric ulcerogenic effect compared to aspirin in our primary study." | 3.73 | Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug. ( Ding, Y; Du, GH; He, XL; Zhang, B, 2006) |
| "In 674 upper gastrointestinal bleeders, we found that the odds ratio for the presence of erosive oesophagitis in aspirin users was 2 (95% CI, 1-3; P = 0." | 3.73 | Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy. ( Angerson, WJ; Blatchford, O; Knill-Jones, RP; Taha, AS, 2006) |
| "Reactive oxygen species, neutrophil infiltration and proinflammatory cytokines play an important role in the pathogenesis of gastric ulcers caused by aspirin." | 3.73 | Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis. ( Jainu, M; Shyamala Devi, CS, 2005) |
| " Ulcer score was calculated for cysteamine-induced duodenal ulcer model." | 3.72 | Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus. ( Anoop, A; Jegadeesan, M, 2003) |
| "Gastric ulcers were induced in normal/NIDDM rats by various physical (2 hr cold restraint stress and 4 hr pylorus ligation) and chemical agents (ethanol, 1 ml/200 g, oral, 1 hr before; aspirin, 200 mg/kg, oral, 4 hr) and duodenal ulcers were induced by cysteamine (40 mg/200 g)." | 3.72 | Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats. ( Agrawal, VK; Aryya, NC; Dorababu, M; Goel, RK; Prabha, T; Priyambada, S, 2004) |
| " We evaluated its anti-ulcerogenic activity in cold restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models in Sprague-Dawley rats, histamine-induced duodenal (HST) ulcer in guinea pigs, and ulcer-healing activity, in acetic acid-induced (AC) chronic ulcer model." | 3.72 | Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. ( Dharmani, P; Kuchibhotla, VK; Maurya, R; Palit, G; Sharma, S; Srivastava, S, 2004) |
| "Gastric ulcers were induced in Wistar rats (male, 200 +/- 25 g), by 150 mg/kg acidified aspirin application." | 3.72 | The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa. ( Akbulut, KG; Celebi, N; Gönül, B; Ozer, C; Yetkin, G, 2004) |
| "The effects of beta(3) adrenergic receptor agonists, (S)-4-[2-hydroxy-3-phenoxy-propylamino-ethoxy]-N-(2-methoxyethyl)-phenoxyacetamide (ZD 7114) and (+/-)-4-(3-t-butylamino-2-hydroxypropoxy)benzimidazol-2-one (CGP 12177A), were studied on aspirin plus pylorus ligation-induced gastric ulcers, gastric mucosal blood flow and gastric motility in rats." | 3.71 | Gastroprotective effect of beta3 adrenoreceptor agonists ZD 7114 and CGP 12177A in rats. ( Goswami, S; Paul, A; Santani, D; Sevak, R, 2002) |
| "The present study was designed to evaluate the effects of a potassium channel opener, nicorandil, and to elucidate its possible mechanism of action in aspirin plus pylorus ligation induced and ethanol-induced gastric ulcers in rats." | 3.71 | Evaluation of the effects of nicorandil on experimentally induced gastric ulcers. ( Goswami, SG; Patel, HM; Santani, DD, 2001) |
| "9), when given in the dose of 10-50 mg/kg, twice daily for 5 days, showed dose-dependent anti-ulcerogenic on various gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation." | 3.71 | Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. ( Babu, MD; Goel, RK; Rao, CV; Sairam, K, 2001) |
| "ethanol-induced gastric lesion, aspirin-induced gastric ulcer, acetic acid-induced ulcer and Shay ulcer." | 3.71 | Effect of butanol fraction of Panax ginseng head on gastric lesion and ulcer. ( Jeong, CS, 2002) |
| "The gastroprotective effect of the labdane diterpene solidagenone was assessed on gastric ulcer in rats." | 3.71 | Gastroprotective activity of solidagenone on experimentally-induced gastric lesions in rats. ( Astudillo, L; Bustamante, C; Rodríguez, JA; Schmeda-Hirschmann, G, 2002) |
| "The gastroprotective effect of the triterpene oleanolic acid (OA) was assessed on gastric ulceration in rats." | 3.71 | Gastroprotective activity of oleanolic acid derivatives on experimentally induced gastric lesions in rats and mice. ( Astudillo, L; Rodriguez, JA; Schmeda-Hirschmann, G, 2002) |
| "Based on our previous studies that aspirin (ASA) -induced gastric ulceration in rats can be significantly reduced if the drug is chemically associated with phosphatidylcholine (PC), we undertook the present study to compare gastric ulcer healing rates in rats administered either unmodified or PC-complexed ASA." | 3.70 | Phosphatidylcholine-associated aspirin accelerates healing of gastric ulcers in rats. ( Kurinets, A; Lichtenberger, LM, 1998) |
| "Effects of selective cyclooxygenase-2 (COX-2) inhibitors (NS-398) and nitric oxide (NO) -releasing aspirin (NO-ASA) on gastric ulcerogenic and healing responses were examined in comparison with nonselective COX inhibitors such as indomethacin and aspirin (ASA)." | 3.70 | Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. ( Kato, S; Takeuchi, K; Ukawa, H; Yamakuni, H, 1998) |
| "The anti-ulcer effects of nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester] were examined on water-immersion plus restraint stress-induced and aspirin-induced gastric ulcers in rats, compared with those of cimetidine." | 3.70 | Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. ( Akima, M; Katsuyama, I; Sakai, K, 1999) |
| "The effect of hypotonic medium (Distilled water: DW) and hypertonic saline (HS: 5% NaCl) compared to control normal saline (NS) was studied on gastric ulcer induced by aspirin, 6 h cold restraint stress, ethanol, and pylorus ligation in rats." | 3.70 | Effect of mild irritant on gastric mucosal offensive and defensive factors. ( Goel, RK; Maiti, RN; Rao, CV, 2000) |
| "Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation." | 3.70 | Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids. ( Abdul Salam, CA; Nag Chaudhuri, AK; Pal, S; Sen, S; Sen, T, 2000) |
| "Both, nitric oxide-releasing aspirin and naproxen dose-dependently attenuated ethanol-induced damage and produced a significant rise in gastric blood flow but did not delay healing of gastric ulcers while native aspirin and naproxen had no influence on ethanol-induced gastric damage but significantly prolonged ulcer healing, reduced gastric blood flow and suppressed mucosal generation of prostaglandin E2." | 3.70 | Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs. ( Brzozowski, T; Drozdowicz, D; Hahn, E; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z, 2000) |
| " (BMJ) commonly known as Brahmi in Hindi was examined using gastric ulcer models induced by ethanol, aspirin, 2 h cold restraint stress and 4 h pylorus ligation." | 3.70 | Experimental evaluation of Bocopa monniera on rat gastric ulceration and secretion. ( Goel, RK; Rao, CV; Sairam, K, 2000) |
| "Anti-ulcerogenic activity of the methanolic extracts of 4 medicinal plants were studied in aspirin-induced gastric ulcers in rats." | 3.69 | Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats. ( Ahmad, KU; Akhtar, AH, 1995) |
| "The results showed that Huanglion decoction has protective effect on ethanol-,HCl- and aspirin-induced gastric hemorrhagic lesions in rats and antemetic effect on CuSO4-induced vomiting in pigeons." | 3.69 | [Pharmacological studies on the effects of huanglian decoction on experimental gastric lesions in rats and antiemetic in pigeons]. ( Cheng, ZM; Liu, JY; Qin, CL, 1994) |
| "We have examined the protective effect of liquorice or its derivatives against gastric ulcer induced by aspirin." | 3.69 | The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats. ( Dehpour, AR; Samadian, T; Vahedi, Y; Zolfaghari, ME, 1994) |
| " Gastric ulcers were induced by application of acetic acid using a standard technique." | 3.69 | Effects of misoprostol on delayed ulcer healing induced by aspirin. ( Andrews, FJ; O'Brien, PE; Penney, AG, 1994) |
| " Dogs treated with aspirin developed NSAID-induced gastropathy (including gastric ulceration), and the degree of endoscopically detectable damage correlated well with sucrose permeability." | 3.69 | Noninvasive detection of nonsteroidal anti-inflammatory drug-induced gastropathy in dogs. ( Kirk, D; Meddings, JB; Olson, ME, 1995) |
| "Studies were performed in three models of acute gastric mucosal damage (induced by oral ethanol, aspirin and indomethacin) and a model of chronic gastritis (induced by 7 day treatment with iodoacetamide) in rats to establish the role of leukotrienes (LTs) in the pathogenesis of these lesions." | 3.69 | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. ( Gyömber, E; Rainsford, KD; Szabo, S; Vattay, P, 1996) |
| "The effect of cromakalim, a potassium-channel opener, was studied on pylorus ligation-induced, aspirin-induced and water-immersion plus restraint stress-induced gastric ulcers in rats and on histamine-induced duodenal ulcer in guinea-pigs." | 3.69 | Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs. ( Goswami, S; Jain, S; Santani, D, 1997) |
| "Chronic gastric ulcers were induced with acetic acid in male Wistar rats and then treated with either aspirin (100 mg/kg/day), indomethacin (2 mg/kg/day), PDGF-BB (0." | 3.69 | Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing. ( Arceiz, E; Lanas, A; Ortego, J; Sáinz, R, 1997) |
| " Administration of bFGF (3-300 micrograms/kg/day) by an intragastric or an intraperitoneal route or sucralfate (400 mg/kg/day) orally to rats with acetic acid induced gastric ulcers, enhanced the healing rate of these ulcers during seven day treatment in a dose dependent manner." | 3.68 | Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate. ( Bielanski, W; Brzozowski, T; Konturek, SJ; Majka, J; Otto, W; Stachura, J; Szlachcic, A, 1993) |
| " Seven of those patients (88%) had benign disease, including aspirin-induced gastric ulcers of the greater curvature (n = 4), granulomatous colitis (n = 1), tuberculosis (n = 1), and a penetrating anastomotic ulcer after partial gastrectomy (n = 1)." | 3.68 | Gastrocolic fistulas: the increasing role of aspirin. ( Herlinger, H; Kelly, MR; Laufer, I; Levine, MS; Rubesin, SE, 1993) |
| " Water-immersion restraint stress- and aspirin-induced gastric ulcers were also significantly prevented in a dose-related manner by oral pretreatment with DS-4574 (10-50 mg/kg)." | 3.68 | Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. ( Kurebayashi, Y; Tabuchi, Y, 1992) |
| "Low-dose aspirin is widely used in patients operated on for coronary disease as secondary prevention of coronary artery occlusion." | 3.68 | Gastric changes in coronary-operated patients with low-dose aspirin. ( Kivilaakso, E; Leivonen, M; Sipponen, P, 1992) |
| "The effect of capsaicin-sensitive nerve degeneration (capsaicin-treatment) was investigated on the antral ulcer induction by the combined administration of 2-deoxy-D-glucose (2-DG; 200 mg/kg, i." | 3.68 | Aggravation by the capsaicin-treatment of gastric antral ulcer induced by the combination of 2-deoxy-D-glucose, aspirin and ammonia in rats. ( Uchida, M; Watanabe, K; Yano, S, 1991) |
| "A double-blind study was conducted to compare gastric ulcer healing time in nontreated dogs with that in dogs treated with either cimetidine or omeprazole." | 3.68 | Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs. ( Bright, RM; DeNovo, RC; Jenkins, CC; Patton, CS; Rohrbach, BW, 1991) |
| "The effect of verapamil, a calcium channel blocker, was studied against stress (cold restraint), aspirin and pylorus ligation induced gastric ulcers in rats." | 3.68 | Protection against gastric ulcer by verapamil. ( Dhawan, KN; Gupta, GP; Gupta, MB; Nath, C; Sinha, JN; Srivastava, SK; Vrat, S, 1991) |
| " Z-103 given orally prevented development of gastric lesions induced by water immersion stress, histamine, HCl-aspirin, HCl-ethanol and also duodenal ulcers induced by mepirizole in a dose-dependent manner." | 3.68 | [Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)]. ( Aita, H; Hori, Y; Morita, H; Okabe, S; Seiki, M; Soeda, M; Tagashira, E; Tanaka, Y; Ueki, S; Yoneta, T, 1990) |
| "We describe 13 patients who developed erosive gastritis with overt gastrointestinal bleeding while receiving 75-250 mg nonbuffered aspirin per day for the secondary prevention of cardiac or cerebrovascular events." | 3.68 | Overt gastrointestinal bleeding in the course of chronic low-dose aspirin administration for secondary prevention of arterial occlusive disease. ( Bassan, H; Levy, N; Naschitz, JE; Odeh, M; Rosner, I; Stermer, E; Yeshurun, D, 1990) |
| "Piracetam, used clinically for cognitive disorders, was found to have significant anti-ulcerogenic activity against immobilization stress- and aspirin-induced gastric ulcers in rats." | 3.68 | Effect of piracetam, a nootropic agent, on experimental gastric ulcers in rat. ( Abbas, WR; Bhattacharya, SK; Chakravarty, M; Goel, RK; Singh, KP, 1990) |
| "Effect of the anti-anxiety drug clotiazepam on the experimental gastric ulceration induced by restraint and water-immersion stress or aspirin was studied in rats." | 3.67 | Antiulcer activity of clotiazepam in rats. ( Haga, K; Nakanishi, A; Osuga, K; Tsumagari, T, 1984) |
| " I-L increased the mucopolysaccharide contents (hexosamine, uronic and sialic acids) in the gastric mucosa of intact rats and inhibited the decrease of mucopolysaccharide contents in the gastric mucosa of rats with phenylbutazone-induced gastric ulcers." | 3.67 | Studies on pharmacological activation of human serum immunoglobulin G by chemical modification and active subfragments. III. Mechanism of anti-ulcerous action of alkylated light chain (Fr. I-L). ( Aonuma, S; Iwai, M; Kohda, I; Maeda, K; Mimura, T; Tsujikawa, K, 1984) |
| " reduced dose-dependent gastric ulcer formation induced by acidified aspirin (ASA), Hoe 892 being somewhat less potent than PGI2." | 3.67 | Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats. ( Brzozowski, T; Konturek, SJ; Pastucki, I; Radecki, T, 1984) |
| "The effect of bromocriptine, a dopamine receptor agonist, has been studied on the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats." | 3.67 | Effect of bromocriptine, a dopamine receptor agonist, on the experimentally induced gastric ulcers in albino rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1984) |
| "Trimipramine, a tricyclic antidepressant, significantly inhibited the development of experimental gastric ulcers induced by various methods like stress, drug (aspirin, reserpine) and Shay's pyloric ligation in an inbred strain of albino rats." | 3.67 | Antiulcer effects of trimipramine using various laboratory models. ( Aguwa, CN; Ramanujam, TR, 1984) |
| "This study shows that human fundic mucosa generates various PGs, particularly PGE2, and thromboxanes and this generation appears to be significantly lower in gastric ulcer than in duodenal ulcer patients or normal subjects." | 3.67 | Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC). ( Konturek, SJ; Kopp, B; Kwiecień, N; Obtułowicz, W; Oleksy, J; Sito, E, 1984) |
| "Gastric ulcerations were produced in rats by oral administration of aspirin (ASA) suspended in a vehicle consisting of either water or increasing concentrations of HCl (0." | 3.67 | Distinction between antiulcer effect and cytoprotection. ( Davis, JP; Field, SO; Lancaster, C; Nezamis, JE; Robert, A, 1984) |
| " Acutely induced gastric ulcers or erosions such as Shay ulcers, water-immersion stress-, indomethacin-, aspirin-, or prednisolone-induced erosions were all markedly inhibited by oral or intraduodenal administration of 10-100 mg/kg of omeprazole." | 3.67 | Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. ( Okabe, S; Okada, Y; Yamamoto, O, 1984) |
| "Antiulcerogenic activities of three plant drugs were studied against aspirin-induced gastric ulcers in rats." | 3.67 | Evaluation of the gastric antiulcerogenic effects of Solanum nigrum, Brassica oleracea and Ocimum basilicum in rats. ( Akhtar, MS; Munir, M, 1989) |
| " AY-28,200 blocked acetylsalicylic acid and stress-induced gastric ulcers but was inactive against indomethacin-induced gastric ulcers." | 3.67 | Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester. ( Borella, LE; DiJoseph, JF, 1989) |
| " Whereas gastric ulcers were produced by ulcerogenic agents including indomethacin, aspirin and reserpine, beside hypothermic restraint stress and by pylorus ligated Shay rat technique." | 3.67 | Gastroprotective activity of ginger zingiber officinale rosc., in albino rats. ( Ageel, AM; al-Yahya, MA; Mossa, JS; Parmar, NS; Rafatullah, S; Tariq, M, 1989) |
| ") inhibited restraint and water-immersion-induced stress, ulcers, indometacin- and absolute ethanol-induced gastric ulcers and mepirizole-induced duodenal ulcers in rats in a dose-dependent manner." | 3.67 | Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats. ( Bickel, M; Goto, M; Hayashi, S; Herling, AW; Sakurai, M; Tanaka, T, 1989) |
| " Magaldrate afforded protection against gastric necrotic lesions induced by absolute ethanol (ED50, as magaldrate, 419 mg/kg); gastric ulcers induced by acidified acetylsalicylic acid (ED50 540 mg/kg), stress (cold restraint, ED50 388 mg/kg), indometacin (ED50 281 mg/kg), and pylorus ligation; and intestinal ulcers induced by cysteamine (ED50 243 mg/kg) and indometacin (ED50 184 mg/kg)." | 3.67 | Cytoprotective and antiulcer activities of the antacid magaldrate in the rat. ( Borella, LE; DiJoseph, JF; Mir, GN, 1989) |
| ", prevented the formation of gastric ulcers induced by exposure to stress, pylorus-ligation, both pylorus-ligation and acetylsalicyclic acid, indometacin or reserpine in rats." | 3.67 | Effects of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)-acetoxyacetamide hydrochloride (TZU-0460), a histamine H2-receptor antagonist, on gastric acid secretion and ulcer formation. ( Mieda, M; Sakuma, H; Shiratsuchi, K; Tarutani, M, 1985) |
| " In contrast with atropine and ranitidine, BN 52021 did not affect the gastric hypersecretion in pylorus-ligated rats nor the aspirin-induced gastric ulcerations." | 3.67 | Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations. ( Braquet, P; Clostre, F; Etienne, A; Mencia-Huerta, JM, 1988) |
| " As a model to explore these questions, the effect of oral administration of aspirin or ethanol on gastric lesion formation was examined in rats with or without established adjuvant-induced polyarthritis." | 3.67 | Altered susceptibility of arthritic rats to the gastric lesion-inducing effects of aspirin or ethanol and the antilesion effect of rioprostil. ( Fuller, BL; Genna, T; Katz, LB; Shriver, DA; Tolman, EL, 1987) |
| "A case-control study was performed to determine whether aspirin confers a similar risk of bleeding from gastric or duodenal ulcers in the elderly as non-aspirin, non-steroidal anti-inflammatory drugs." | 3.67 | Aspirin and bleeding peptic ulcers in the elderly. ( Faulkner, G; Langman, MJ; Prichard, P; Somerville, K, 1988) |
| "Adrenalectomy enhances the degree of gastric ulcers induced in rats by indomethacin or acetylsalicylic acid (ASA), but not that induced by 96% ethanol." | 3.67 | Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism". ( Evangelista, S; Giuliani, S; Maggi, CA; Meli, A, 1988) |
| " The anti-inflammatory properties of FPP028 were evaluated through the carrageenan induced paw edema and the cotton pellet induced granuloma and compared with the activity of indomethacin, phenylbutazone, and isoxicam; as a result, the activity of FPP028 was shown to be similar to that of the latter compounds." | 3.67 | Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent. ( Banchelli, G; Bianchini, F; Ignesti, G; Pecori-Vettori, L; Pirisino, R; Rafanelli, D; Raimondi, L, 1986) |
| " Arbaprostil, given orally in doses of 1-100 micrograms/kg twice daily for 2 weeks, had little or no effect on the healing of acetic acid-induced gastric ulcers." | 3.67 | Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. ( Jino, H; Nishida, A; Okabe, S, 1986) |
| "Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear." | 3.67 | Peptic ulcer and non-steroidal anti-inflammatory agents. ( Dobson, AJ; Duggan, JM; Fahey, P; Johnson, H, 1986) |
| " It inhibited dose dependently gastric ulcers produced by acidified aspirin, water immersion and restraint stress." | 3.67 | Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins. ( Aihara, H; Brzozowski, T; Drozdowicz, D; Konturek, SJ; Muramatsu, M; Piastucki, I; Radecki, T; Tanaka, M, 1986) |
| " There does not appear to be any involvement of PAF in non-inflammatory gastric ulceration induced by aspirin or ethanol+HCl, since the PAF antagonist kadsurenone fails to exert any protective effects when co-administered with either of these drugs." | 3.67 | Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. ( Rainsford, KD, 1986) |
| " Acetazolamide increased the gastric ulcerogenicity of indomethacin, but inhibited gastric ulcers produced by acidified aspirin." | 3.67 | Ulcer formation and cytoprotection by acetazolamide. ( Davis, JP; Kolbasa, KP; Lancaster, C; Nezamis, JE; Robert, A, 1985) |
| " prevented formation of ulcers induced by serotonin, indomethacin, acetylsalicylic acid or stress (acute ulcer models), its effect being greater against gastric ulcers induced by serotonin." | 3.67 | Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103). ( Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N, 1985) |
| "The effect of domperidone, a peripheral dopamine receptor antagonist, has been studied in the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats." | 3.67 | Effect of domperidone on experimentally induced gastric ulcers in rats. ( Ageel, AM; Al-Khamis, KI; Parmar, NS; Tariq, M, 1986) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 3.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| ") inhibited the development of gastric ulcers induced by pylorus ligation, water-immersion stress, aspirin and reserpine and duodenal ulcers induced by cysteamine in rats." | 3.67 | Effect of elcatonin on experimental gastric and duodenal ulcers. ( Noguchi, M; Ohno, H; Takayanagi, N, 1985) |
| " Oral or intraduodenal administration of AG 629 in a dose range of 25-100 mg/kg inhibited water-immersion stress ulcer, exertion ulcer, Shay ulcer, indometacin- and acetylsalicylic acid (ASA)-induced gastric ulcer, and indomethacin-induced small intestinal ulcer in rats, histamine-induced gastric ulcer in guinea pigs, and ASA-induced gastric ulcer in dogs, though it was not effective against cysteamine-induced duodenal ulcer in rats." | 3.67 | Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers. ( Hirata, T; Inada, I; Inatomi, N; Maki, Y; Satoh, H; Sino, A, 1985) |
| "Gastric ulcers were produced in conscious cats in 3 hr by simultaneous intravenous or intragastric administration of acetylsalicylic acid (ASA), plus intravenous infusion of histamine (80 micrograms/kg/hr), pentagastrin (8 micrograms/kg/hr), or intragastric instillation of HCl." | 3.66 | Aspirin-induced gastric ulcers in cats. Prevention by prostacyclin. ( Brzozowski, T; Dembińska-Kieć, A; Konturek, SJ; Piastucki, I; Radecki, T; Zmuda, A, 1981) |
| "Sodium salicylate (SA) has been reported to inhibit the formation of gastric ulcerations induced by aspirin, indomethacin, and absolute ethanol." | 3.66 | Effect of prostaglandin synthesis inhibitors on neurotensin and sodium salicylate-induced gastric cytoprotection in rats. ( Adcock, JE; Hernandez, DE; Nemeroff, CB; Prange, AJ, 1983) |
| "To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findings." | 3.66 | Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats. ( Kitaura, T; Kunita, T; Miyoshi, A; Ohe, K; Yokoya, H, 1980) |
| ") also inhibited gastric ulcers provoked by aspirin, aspirin + acid, indomethacin and stress (cold-restraint) in rats." | 3.66 | Gastric antisecretory and cytoprotective activities of SCH 28080. ( Chiu, PJ; Derelanko, MJ; Long, JF; Steinberg, M, 1983) |
| " However, SM powder had no effect on water-immersion stress- or aspirin-induced gastric lesions and mepirizole-induced duodenal ulcers." | 3.66 | [Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats]. ( Ikenishi, H; Ohmi, F; Okabe, S; Takaoka, A; Takeuchi, K, 1983) |
| "Antiulcer effects of geranylgeranylacetone (GGA) on aspirin-induced gastric ulcers in rats were studied, comparing them with those of gefarnate." | 3.66 | Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats. ( Fujisaki, H; Murakami, M; Ohgo, T; Okabe, S; Oketani, K; Wakabayashi, T, 1982) |
| "Benign gastric ulceration occurred in a patient with pernicious anemia in association with aspirin therapy." | 3.66 | Benign gastric ulceration in pernicious anemia. ( Heading, RC; Holt, S; Reid, J; Taylor, TV, 1980) |
| "In unanesthetized cats, continuous intravenous infusion of aspirin for 36 hr did not produce gastric ulcers when given alone but did when combined with 160 microgram kg-1 hr-1 of histamine-2HCl intravenously." | 3.66 | Histamine augments gastric ulceration produced by intravenous aspirin in cats. ( Aures, D; Grossman, MI; Hansen, DG, 1978) |
| "Gastric ulceration produced by aspirin and indomethacin was compared in acutely stressed and non-stressed rats." | 3.66 | Aspirin- and indomethacin-induced ulcers and their antagonism by antihistamines. ( Brown, PA; Sawrey, JM; Vernikos, J, 1978) |
| " Concomitant oral administration of aspirin or subcutaneous administration of indomethacin revealed an aggravation of aspirin-induced gastric ulcers by betamethasone valerate and inhibition of indomethacin-induced intestinal ulcers by beta-methasone dipropionate." | 3.66 | [Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs (author's transl)]. ( Ishihara, Y; Izumi, K; Kunimi, H; Okabe, S; Tabata, K; Uchida, N, 1978) |
| "The effects of cimetidine, a new histamine H2-receptor antagonist, on the development of experimental gastric and duodenal ulcers were studied." | 3.65 | Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. ( Okabe, S; Takagi, K; Takeuchi, K; Urushidani, T, 1977) |
| "In eastern Australia, there is an epidemic of gastric ulcer which began 30 years in young women who are now middle-aged, (b) This epidemic is associated with the regular use of aspirin most often in the form of A." | 3.65 | Aspirin and ulcers. ( Duggan, JM, 1977) |
| "Ionic permeability of the gastric mucosa was measured in six patients with an acute exacerbation of severe generalized rheumatoid arthritis receiving either aspirin and prednisone or aspirin and indomethacin as therapy." | 3.65 | Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. ( Clifton, JA; Ivey, KJ, 1974) |
| "Rabeprazole was well tolerated at both doses." | 2.79 | Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. ( Arakawa, T; Fujimoto, K; Fujishiro, M; Higuchi, K; Iwakiri, R; Kato, M; Kinoshita, Y; Nakagawa, H; Ogawa, H; Okada, Y; Sanomura, M; Sugisaki, N; Takeuchi, T; Watanabe, T; Yamauchi, M, 2014) |
| "pylori gastritis was present than when it was absent, despite similar degrees of gastric mucosal prostaglandin depletion." | 2.70 | Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial. ( Cryer, B; Feldman, M; Go, MF; Mallat, D, 2001) |
| "Gastric ulcers were noted in eight subjects in the aspirin group, one in the placebo group, and none in the risedronate group (P=0." | 2.69 | Placebo-controlled, randomized, evaluator-blinded endoscopy study of risedronate vs. aspirin in healthy postmenopausal women. ( Blank, MA; Krajewski, SA; Lanza, FL; Li, Z; Rack, MF, 2000) |
| " Even when used according to manufacturer's dosing instructions alendronate should probably be used with caution." | 2.68 | Primary amino-bisphosphonates: a new class of gastrotoxic drugs--comparison of alendronate and aspirin. ( Goodgame, R; Graham, DY; Malaty, HM, 1997) |
| " The data indicate that ticlopidine is better tolerated by the gastroduodenal mucosa than low dosage aspirin." | 2.67 | [A comparison of the gastroduodenal tolerance of ticlopidine and acetylsalicylic acid]. ( Kleinsorge, H; Müller, P; Simon, B, 1993) |
| "Misoprostol is a synthetic prostaglandin E1 analogue that inhibits gastric acid production and may augment mucosal defense." | 2.66 | Misoprostol reduces gastroduodenal injury from one week of aspirin: an endoscopic study. ( Jiranek, GC; Kimmey, MB; Saunders, DR; Shanahan, W; Silverstein, FE; Willson, RA, 1989) |
| " Furthermore, there is growing evidence that long-term use of aspirin decreases the risk of colorectal cancer, even at low doses." | 2.47 | Gastrointestinal effects of aspirin. ( Lanas, A; Sostres, C, 2011) |
| " The introduction of new classes of drugs has resulted in new adverse effects that require consideration in patients presenting with gastroenterological symptoms." | 2.43 | Drug-induced side effects affecting the gastrointestinal tract. ( Chan, FK; Leong, RW, 2006) |
| "Aspirin is a very useful medication for the prevention of cardiovascular thrombotic events in patients with or those at risk for cardiovascular disease (CVD)." | 2.42 | Cardioprotective effects and gastrointestinal risks of aspirin: maintaining the delicate balance. ( Kimmey, MB, 2004) |
| " This dose-response effect, evident in both endoscopic and microbleeding studies done after acute or short-term aspirin administration, is also associated with the risk of developing chronic gastric ulcer." | 2.37 | Aspirin and the stomach. ( Graham, DY; Smith, JL, 1986) |
| "Chronic gastric ulcer is linked to aspirin intake in patients with rheumatic disease, and epidemiologically in all heavy aspirin users; paradoxically, in only one epidemiologic study was a significant association found between acetaminophen intake and chronic gastric ulcer." | 2.36 | Gastrointestinal effects of antipyretic analgesics. ( Ivey, KJ, 1983) |
| "Many drugs have been restricted in the treatment of gastric ulcers (GU)." | 1.91 | Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin ( AbdElkader, NA; Ageez, AM; Bawish, BM; Elsharkawy, SH; Gohari, ST; Ismail, EM; Kamel, S; Khattab, MS; Rabab, MA; Zaki, MM, 2023) |
| "Aspirin is a nonsteroidal anti-inflammatory drug that is very effective in the treatment of inflammation and other health conditions, however, it causes gastric irritation." | 1.56 | Anti-Inflammatory and Gastroprotective Properties of Aspirin - Entrapped Solid Lipid Microparticles. ( Akpa, PA; Attama, AA; Chime, SA; Ugwuanyi, CC, 2020) |
| "Carvedilol succeeded to enhance antioxidants in gastric tissue, attenuated lipid peroxidative parameters, and suppressed the release of inflammatory mediators." | 1.56 | Carvedilol safeguards against aspirin-induced gastric damage in rats. ( Ahmed, I; Ahmed, N; Bazarbay, AA; El-Agamy, DS; Elkablawy, MA, 2020) |
| "It is well established that long-term use of aspirin can cause gastric mucosal injury." | 1.51 | Increased risk of aspirin-induced gastric mucosal erosion in elderly Chinese men harboring SLCO1B1*1b/*1b while using aspirin and an ACEI or ARB concomitantly. ( Bai, Y; Duan, L; Li, H; Li, M; Li, Y; Liu, H, 2019) |
| "Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa." | 1.51 | Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. ( Abd El-Ghffar, EA; Mahmoud, YI, 2019) |
| " However, administration of aspirin causes toxic effects, especially in the stomach and liver." | 1.46 | Nullification of aspirin induced gastrotoxicity and hepatotoxicity by prior administration of wheat germ oil in Mus musculus: histopathological, ultrastructural and molecular studies. ( Hamad, SR; Mohamed, HRH, 2017) |
| "There are many available drugs for treating gastric ulcer, but they have various side effects." | 1.42 | The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies. ( Salah Khalil, M, 2015) |
| "Large-dose or long-term use of aspirin tends to cause gastric mucosa injury, which is recognized as the major side effect of aspirin." | 1.40 | Involvement of glutamate-cystine/glutamate transporter system in aspirin-induced acute gastric mucosa injury. ( Du, J; Li, WQ; Li, XH; Li, YJ; Peng, J; Wu, YH; Yang, YM; Zhang, W, 2014) |
| "The risk of postoperative hemorrhage following gastric ESD was higher in patients with antithrombotic therapy than in those without that therapy." | 1.39 | The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. ( Edogawa, S; Harada, S; Higuchi, K; Kojima, Y; Ota, K; Takeuchi, T; Tokioka, S; Umegaki, E, 2013) |
| "Gastric ulcers were induced in mice by oral administration of hydrochloride (HCl)/ethanol or acidified aspirin." | 1.38 | Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models. ( Hara, H; Ishibashi, T; Murata, K; Oyagi, A; Shimazawa, M; Takahira, D; Tsuruma, K, 2012) |
| "Pre-treatment with arbutin or omeprazole protected the gastric mucosa as seen by reduction in ulcer area and mucosal content, reduced or absence of edema, inflammation and leucocytes infiltration on both models." | 1.38 | Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. ( Abdelwahab, SI; Abdulla, MA; Ali, HM; Hadi, AH; Salga, MS; Taha, MM, 2012) |
| "Gastric ulcer was induced by administering alcohol (or) acetylsalicylic acid (or) hypothermic restraint stress to rats pretreated with HAEPD (200 mg/kgbwt for 30 day)." | 1.38 | Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. ( Geetha, A; Megala, J, 2012) |
| "Pretreatment with melatonin or tryptophan remarkably reduced ASA induced gastric lesions and microbleeding." | 1.36 | Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans. ( Bielanski, W; Celinski, K; Cichoz-Lach, H; Konturek, PC; Konturek, SJ; Reiter, RJ; Slomka, M, 2010) |
| "The incidence of esophageal and gastric cancers was high at 5." | 1.36 | Impact of upper gastrointestinal lesions in patients on low-dose aspirin therapy: preliminary study. ( Kawai, T; Watanabe, M; Yamashina, A, 2010) |
| "The aetiology of gastric ulcers is not completely understood and continuous use of anti-ulcer agents leads to many side effects." | 1.36 | Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats. ( Arjuman, A; Bhargavan, D; Chatterji, D; Dorababu, P; Gopalakrishna, HN; Mirshad, PV; Nair, V, 2010) |
| "The aspirin prodrug ( 23) was a 2." | 1.35 | Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. ( Chen, QH; Citro, ML; Keefer, LK; Knaus, EE; Velázquez, CA, 2008) |
| "Gastroduodenal ulcers were found in 19 of 101 (18." | 1.35 | Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease. ( Asaka, M; Kato, M; Katsurada, T; Kawai, Y; Nema, H; Nozaki, Y; Okusa, T; Sakurai, M; Sato, K; Takagi, Y; Takiguchi, S; Yoshida, I; Yotsukura, A, 2008) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| " The objectives of the current study were to comprehensively define the developmental toxicology profile of ASA in rabbits by using a dosing paradigm encompassing the period of organogenesis and to test the hypothesis that maternal gastrointestinal toxicity after repeated dose administrations hampers the detection of low-incidence malformations with ASA in rabbits by limiting ASA administration to sensitive windows for cardiovascular development and midline closure." | 1.32 | Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development. ( Cappon, GD; Cook, JC; Gupta, U; Hurtt, ME; Tassinari, MS, 2003) |
| " An initial dose-response study using 12." | 1.32 | Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats. ( Agrawal, VK; Dora Babu, M; Goel, RK; Prabha, T; Priyambada, S, 2003) |
| "Aspirin was found to cause severe haemorrhagic lesions mainly through oxidative damage of the mucosa as indicated by increased lipid peroxidation, conjugated diene, protein carbonyl content, decreased levels of antioxidant defense enzymes and alteration in the lipid levels." | 1.32 | Effect of ambrex (an amber based formulation) on gastric mucosal damage: role of antioxidant enzymes and lipid profile. ( Devi, CS; Jainu, M, 2004) |
| "Aspirin (500 mg/kg) was given by gavage and repeated 2." | 1.31 | Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats. ( Khuri, M; Mourad, FH; Nassar, CF; Shouaib, F, 2000) |
| "We compared the gastric toxic effect of aspirin (ASA) in both normal and diabetic rats, with that of NCX-4016, a derivative of ASA with nitric oxide (NO) releasing moiety." | 1.31 | Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. ( Fujita, A; Takeuchi, K; Tashima, K; Umeda, M, 2000) |
| "Ticlopidine treatment resulted in increased platelet endostatin content and release." | 1.31 | Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. ( Buret, A; Cirino, G; Elliott, SN; Ignarro, LJ; Ma, L; Wallace, JL, 2001) |
| "In vehicle-treated rats, gastric ulcers healed progressively and at day 14 the healing was completed, accompanied by a significant rise in the GBF at ulcer margin." | 1.31 | Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z, 2001) |
| "Aspirin was associated with higher risk of upper gastrointestinal bleeding: OR=1." | 1.31 | [Upper gastrointestinal bleeding in patients treated by low-dose aspirin]. ( Amouretti, M; Capet, C; Colin, R; Czernichow, P; Dupas, JL; Goria, O; Gouérou, H; Herman, H; Hochain, P, 2001) |
| "The gastric toxic effects of aspirin (ASA) and NCX-4016, a nitric oxide (NO)-releasing ASA, were compared in normal, cirrhotic, and arthritic rats." | 1.31 | Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis. ( Kato, S; Komoike, Y; Suzuki, K; Takeuchi, K; Ukawa, H, 2001) |
| " Three h after dosing with 50 mg/kg acidified aspirin, there was superficial mucosal damage and decreased mucin content in the surface mucosal layer." | 1.30 | Recovery of mucin content in surface layer of rat gastric mucosa after HCl-aspirin-induced mucosal damage. ( Hotta, K; Ishihara, K; Saigenji, K; Sakai, T, 1997) |
| "Both aspalatone and ASA were essentially stable in gastric juice and were absorbed in stomach unchanged." | 1.30 | Salicylate levels in rat stomach tissues after administration of aspalatone and acetylsalicylic acid in relation to their ulcerogenicity. ( Han, BH; Kang, YH; Suh, DY, 1997) |
| "Aspirin itself was ulcerogenic, causing damage in the mucosa when administered p." | 1.30 | Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin. ( Kitamura, M; Konaka, A; Sugawa, Y; Takeuchi, K; Ukawa, H, 1998) |
| "Pretreatment with cimetidine showed a marked protection against this decline in polyamine contents at both the doses tested (37." | 1.30 | Effect of ulceration on rat gastric tissue polyamine contents in response to different procedures; inhibition of these effects by cimetidine. ( Al-shabanah, OA; Raza, M, 1999) |
| " Moreover, 10a demonstrated no ulcerogenesis effect in rats even at 100 mg/kg dosage (safety margin in rats is more than 70 while that of aspirin is only 1." | 1.29 | Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. ( Ishikawa, T; Motoyama, Y; Sakai, H; Takasugi, H; Tanaka, A, 1994) |
| "Yohimbine pretreatment prevented both the increase in juxtamucosal pH gradient depth and the protective effect of nicotine." | 1.29 | Topical nicotine protects rat gastric mucosa against ASA-induced damage. A role for mucosal fluid secretion in cytoprotection. ( Fallone, CA; Morris, GP, 1995) |
| "Aspalatone treatment (15 mg/kg p." | 1.29 | Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity. ( Han, BH; Kang, YH; Kim, YC; Park, YH; Suh, DY; Yang, HO, 1994) |
| "25 or 0h oral dosing of the 5-lipoxygenase inhibitor, MK-886, but not when only one of these doses was given." | 1.29 | Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. ( Rainsford, KD, 1993) |
| "All morphine effects were reversed by naloxone." | 1.28 | Antisecretory and anti-ulcer effects of morphine in rats after gastric mucosal aggression. ( Chariot, J; Del Tacca, M; Rozé, C; Tazi-Saad, K; Vatier, J, 1991) |
| " The second group also of 10 patients was treated with CBS 120 mg qid and after 2 days they received aspirin and CBS simultaneously in the dosage mentioned above for another 4 days." | 1.28 | [Protective effect of colloidal bismuth subcitrate on gastric mucosal lesion induced by aspirin]. ( Chen, J; Chen, SP; Wen, SH, 1990) |
| "(4) Aspirin in 1% CMC was given to 10 rats of each group with the dose of 300 mg/kg body-weight." | 1.28 | [Influence of sucrose on aspirin ulcer]. ( Fujii, A; Okuma, K, 1989) |
| "), rioprostil prevents the acute effects of aspirin on the gastric mucosa of dogs, accelerates the healing of aspirin-induced gastric lesions, and heals preexisting aspirin-induced gastric lesions during chronic administration of aspiring." | 1.28 | Slow release delivery of rioprostil by an osmotic pump inhibits the formation of acute aspirin-induced gastric lesions in dogs and accelerates the healing of chronic lesions without incidence of side effects. ( Katz, LB; Shriver, DA, 1989) |
| " Dogs dosed with PEG followed by aspirin had gastric lesions: mean (+/- S." | 1.28 | Aspirin-induced gastric mucosal damage in dogs: protection by the prostanoid Ro 22-1327. ( Bertko, RJ; Davidovich, A; Finckenor, BA; Gaginella, TS, 1989) |
| "Pretreatment with acetazolamide did not influence the protective action of PGE2 on ethanol-induced mucosal lesions and only slightly inhibited the protective effect of PGE2 on ASA-induced gastric ulcerations." | 1.27 | Gastric cytoprotection by acetazolamide: role of endogenous prostaglandins. ( Brzozowski, T; Konturek, SJ; Piastucki, I; Radecki, T, 1983) |
| "The combination of hemorrhagic shock, aspirin, and acid caused pronounced mucosal lesions, whereas only minor lesions were seen with aspirin and acid alone." | 1.27 | Canine gastric ulcer produced by hemorrhagic shock and aspirin. ( Amdrup, E; Casalnuovo, CA; Kraglund, K; Kristensen, IB, 1984) |
| "Aspirin is a known gastric mucosal barrier breaker and it produces a significant increase of the ulcer index in the restraint rat model." | 1.27 | The effect of 3-methoxy-5,7,3',4'-tetrahydroxyflavan on the restraint induced gastric ulceration augmented by aspirin, a gastric mucosal barrier breaker. ( Hennings, G; Parmar, NS, 1983) |
| "The qualitative changes of gastric mucus glycoproteins occurring after aspirin dosing in rats were further investigated." | 1.27 | Changes of gastric mucus glycoproteins with aspirin administration in rats. ( Azuumi, Y; Goso, K; Hotta, K; Ishihara, K; Ohara, S, 1984) |
| "aspirin were additive." | 1.27 | Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. ( Holsapple, MP; Nichols, DE; Trizzino, J; Yim, GK, 1983) |
| " The inhibition was characterized by displacement of the dose-response to histamine to the right, in parallel, without depression of the maximum." | 1.27 | Actions of nizatidine on the rat uterus, dog stomach and experimentally induced gastric lesions. ( Evans, DC; Lin, TM; Ruffolo, RR; Warrick, MW, 1986) |
| " The plasma concentration of fenflumizole reached a peak 2-3 hr after the dosing in non-fasted as well as fasted rats." | 1.27 | Antithrombotic and ulcerogenic effects of fenflumizole, a new anti-inflammatory imidazole derivative, in rats. ( Nabata, H; Okazaki, A; Sakai, K; Uchino, M; Yamazaki, T, 1987) |
| "Indomethacin pretreatment (10 mg/kg p." | 1.27 | Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions. ( Barnett, A; Brown, AD; Chiu, PJ; Gerhart, C; Siegel, M, 1988) |
| " Meciadanol partially prevented aspirin-induced lesions but the prevention required chronic administration of meciadanol." | 1.27 | Gastric protection by meciadanol. A new synthetic flavonoid inhibiting histidine decarboxylase. ( Brzozowski, T; Kitler, ME; Konturek, SJ; Radecki, T, 1986) |
| " Three weeks later these rats were orally dosed each day with aspirin (375 mg/kg) for six months." | 1.27 | Molecular weight of gastric mucus glycoprotein is a determinant of the degree of subsequent aspirin induced chronic gastric ulceration in the rat. ( Bagshaw, PF; Munster, DJ; Wilson, JG, 1987) |
| "Benzydamine (Tantum) was studied for ulcerogenic and ulcer protective effects in the rat gastric mucosa." | 1.27 | [Experimental findings on gastric ulcerogenicity and mucosa protection by benzydamine in the rat]. ( Hell, I, 1987) |
| "Marked gastric ulcers were induced by indomethacin and diclofenac, and severe intestinal ulcers were also produced at 24 h and by their repeated administration." | 1.27 | Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal ( Kasuya, Y; Urushidani, T; Yano, S, 1986) |
| "indomethacin) have been explored as a means for reducing the gastric ulcerogenicity of the latter." | 1.27 | Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity. ( Rainsford, KD, 1986) |
| " The quantitative morphometric method was sufficiently sensitive to demonstrate a dose-response effect of ethanol and aspirin." | 1.27 | A quantitative method for assessing the extent of experimental gastric erosions and ulcers. ( Bradford, JC; Brown, A; Homan, HD; Schnoor, J; Szabo, S; Trier, JS, 1985) |
| "Pretreatment with nicotine, caffeine, and their combination resulted in significant augmentation of gastric ulcers produced by aspirin, phenylbutazone, and reserpine." | 1.27 | Effect of nicotine and caffeine pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone, and reserpine in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1985) |
| "Pretreatment with nicotine, alcohol and caffeine and their combination resulted in a significant augmentation of gastric lesions produced by aspirin, phenylbutazone and reserpine." | 1.27 | Effect of nicotine, alcohol and caffeine pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine in rats. ( Ageel, AM; Parmar, NS; Tariq, M, 1985) |
| "Gastric mucosal lesions were produced in rats by dosing orally with aspirin, 300 mg/kg." | 1.26 | H2-receptor antagonists protect against aspirin-induced gastric lesions in the rat. ( Bunce, KT; Daly, MJ; Humphray, JM; Stables, R, 1981) |
| " Moreover, no toxic effects were seen after long-term administration of 100-1000 mg/kg/day AME for 3-4 months." | 1.26 | Anti-inflammatory/anti-pyretic salicylic acid esters with low gastric ulcerogenic activity. ( Rainsford, KD; Whitehouse, MW, 1980) |
| "The aspirin solutions were administered with or without atropine (in doses of 4 and 10 mg/kg)." | 1.26 | Experimental evidence for cytoprotective effect of atropine on the rat gastric mucosa. ( Kutor, G; Lovász, L; Mózsik, G; Nagy, L; Tárnok, F, 1980) |
| " Administration of aspirin decreased the gastric mucosal hexosamine and induced the onset of ulcer, while administration of proglumide suppressed the gastric lesions in proportion to dosage and correspondingly prevented a decrease of the hexosamine." | 1.26 | The role of gastric mucosal hexosamine in aspirin-induced ulcers. ( Aono, M; Moriga, M; Murakami, M; Uchino, H, 1980) |
| "Pretreatment with proglumide accelerated GP synthesis in the normal glandular stomach and restored the GP decrease caused by fasting." | 1.26 | Effect of proglumide on glycoprotein synthesis in aspirin-induced gastric erosions in rats. ( Iwaki, K; Kimura, K; Sanai, K; Umetsu, T, 1980) |
| "Aspirin alone was the least frequently ingested." | 1.26 | Analgesic ingestion and chronic peptic ulcer. ( Ariotti, DE; Fenton, BH; MacLennan, R; McIntosh, JH; Piper, DW, 1981) |
| "Aspirin was given by continuous intravenous infusion to 35 intact cats for 7 days in doses ranging from 25 to 200 mg kg-1 day-1." | 1.26 | Gastric mucosal lesions produced by intravenous infusion of aspirin in cats. ( Aures, D; Bugat, R; Grossman, MI; Thompson, MR, 1976) |
| "An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric musoca in contrast to the irritation observed in non-stressed ones." | 1.26 | Effects of L-glutamine of acetylsalicylic acid or taurocholic acid-induced gastric lesions and secretory changes in pylorus-ligated rats under normal or stress conditions. ( Hung, CR; Okabe, S; Takagi, K; Takeuchi, K, 1976) |
| "Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers." | 1.26 | Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1979) |
| "Aspirin tablets were placed in the stomach of anesthetized cats by gastrotomy." | 1.26 | Aspirin damage to ischemic gastric mucosa in shocked cats. ( Leiknes, KA; Svanes, K; Søreide, O; Varhaug, JE, 1979) |
| " The degree of gastric or intestinal irritation seen with dosing of other drugs was as follows; indomethacin greater than diclofenac Na greater than ibuprofen greater than aspirin greater than phenylbutazone or indomethacin greater than CH-800 = diclofenac Na greater than ibuprofen greater than phenylbutazone, respectively." | 1.26 | [Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)]. ( Ohtsuki, H; Okabe, S; Tabata, K, 1979) |
| " In animals pretreated by anti-inflammatory drugs in toxic doses an earlier development of ulceration was observed by distention with acid." | 1.26 | Distention ulcer as a model for testing of drugs for ulcerogenic side effects. ( Szelenyi, I; Thiemer, K, 1978) |
| "Butibufen was within the potency range of ibuprofen as an antipyretic and analgesic agent and greater than that of acetylsalicylic acid." | 1.26 | Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. ( Aparicio, L, 1977) |
| "One hundred consecutive cases of upper gastrointestinal hemorrhage were studied clinically, radiologically and endoscopically." | 1.26 | Upper gastrointestinal hemorrhage clinical, radiological and endoscopic correlation of 100 consecutive cases. ( Dinoso, VP; Lorber, SH; Meshkinpour, H, 1976) |
| "The gastric ulcer is easily detected by a barium meal study although a barium enema may be necessary to show the fistulous communication." | 1.26 | Gastrocolic fistula as a complication of benign gastric ulcer. ( Laufer, I; Stolberg, H; Thornley, GD, 1976) |
| "The factors that determine the recurrence rate of chronic gastric ulcer were studied in 105 patients." | 1.25 | Factors relevant to the prognosis of chronic gastric ulcer. ( Coupland, GA; Greig, M; Hobbin, E; Piper, DW; Shinners, J, 1975) |
| "When aspirin was administered in combination with L-glutamine, the absorption of aspirin was at nearly the same level as when aspirin had been given alone." | 1.25 | Influence of L-glutamine on aspirin-induced gastric lesions and absorptions as well as antipyretic, analgesic and anti-inflammatory effects of aspirin in rats and mice. ( Kiyohara, A; Okabe, S; Orima, H; Suzuki, Y; Takagi, K; Tanaka, H, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 419 (49.53) | 18.7374 |
| 1990's | 133 (15.72) | 18.2507 |
| 2000's | 155 (18.32) | 29.6817 |
| 2010's | 122 (14.42) | 24.3611 |
| 2020's | 17 (2.01) | 2.80 |
| Authors | Studies |
|---|---|
| Paris, GY | 2 |
| Garmaise, DL | 2 |
| Cimon, DG | 2 |
| Swett, L | 2 |
| Carter, GW | 2 |
| Young, P | 2 |
| Safak, C | 2 |
| Erdogan, H | 2 |
| Palaska, E | 2 |
| Sunal, R | 1 |
| Duru, S | 2 |
| Toja, E | 1 |
| Selva, D | 2 |
| Schiatti, P | 2 |
| Tanaka, A | 2 |
| Sakai, H | 1 |
| Motoyama, Y | 2 |
| Ishikawa, T | 1 |
| Takasugi, H | 3 |
| Velázquez, C | 2 |
| Praveen Rao, PN | 2 |
| Knaus, EE | 3 |
| Zheng, X | 1 |
| Oda, H | 1 |
| Takamatsu, K | 1 |
| Sugimoto, Y | 1 |
| Tai, A | 1 |
| Akaho, E | 1 |
| Ali, HI | 1 |
| Oshiki, T | 1 |
| Kakuta, H | 1 |
| Sasaki, K | 1 |
| Tozkoparan, B | 2 |
| Küpeli, E | 3 |
| Yeşilada, E | 2 |
| Ertan, M | 2 |
| Venu, TD | 1 |
| Shashikanth, S | 1 |
| Khanum, SA | 1 |
| Naveen, S | 1 |
| Firdouse, A | 1 |
| Sridhar, MA | 1 |
| Shashidhara Prasad, J | 1 |
| Velázquez, CA | 3 |
| Citro, ML | 2 |
| Keefer, LK | 3 |
| Chen, QH | 1 |
| Khode, S | 1 |
| Maddi, V | 1 |
| Aragade, P | 1 |
| Palkar, M | 1 |
| Ronad, PK | 1 |
| Mamledesai, S | 1 |
| Thippeswamy, AH | 1 |
| Satyanarayana, D | 1 |
| Bansal, S | 1 |
| Bala, M | 1 |
| Suthar, SK | 1 |
| Choudhary, S | 1 |
| Bhattacharya, S | 1 |
| Bhardwaj, V | 1 |
| Singla, S | 1 |
| Joseph, A | 1 |
| Xu, M | 1 |
| Liu, F | 1 |
| Zhou, W | 1 |
| He, B | 1 |
| Tan, S | 1 |
| Ajuka Obasi, N | 1 |
| Aloke, C | 1 |
| Obasi, SE | 1 |
| Ogbonnia Egwu, C | 1 |
| Clement Famurewa, A | 1 |
| Nkemjika Ogbu, P | 1 |
| Kamar, SA | 1 |
| Bayoumi, AH | 1 |
| Rady, HY | 1 |
| Rahman, K | 1 |
| Ali, G | 3 |
| Khan, R | 1 |
| Khan, I | 3 |
| Ali, I | 1 |
| Mosa, OF | 1 |
| Ahmed, A | 1 |
| Ayaz, M | 1 |
| Nawaz, A | 1 |
| Murthy, HCA | 1 |
| Nguyen, TNM | 1 |
| Sha, S | 1 |
| Chen, LJ | 1 |
| Holleczek, B | 1 |
| Brenner, H | 1 |
| Schöttker, B | 1 |
| Yeomans, ND | 6 |
| Ajaib, M | 1 |
| Ishtiaq, S | 1 |
| Ishtiaq, M | 1 |
| Maqbool, M | 1 |
| Bhatti, KH | 1 |
| Khan, A | 1 |
| Afreen, A | 2 |
| Hussain, T | 1 |
| Sardar, T | 1 |
| Gul, A | 1 |
| Azeem, M | 1 |
| Ismail, S | 1 |
| Naveed Mushtaq, M | 1 |
| Shabbir, U | 1 |
| Razzaq, A | 1 |
| Ramzan, HM | 1 |
| Shoukat, A | 1 |
| Ahsan, H | 1 |
| Movafagh, A | 1 |
| Kahrizi, D | 1 |
| Anjum, I | 1 |
| Bawish, BM | 1 |
| Rabab, MA | 1 |
| Gohari, ST | 1 |
| Khattab, MS | 1 |
| AbdElkader, NA | 1 |
| Elsharkawy, SH | 1 |
| Ageez, AM | 1 |
| Zaki, MM | 1 |
| Kamel, S | 1 |
| Ismail, EM | 1 |
| de Freitas Rocha, J | 1 |
| de Castro Viana, L | 1 |
| Filho, LCPA | 1 |
| de Almeida, TS | 1 |
| Neto, JJL | 1 |
| Neto, VV | 1 |
| Tabosa, PMS | 1 |
| Nunes-Pinheiro, DCS | 1 |
| Girão-Carmona, VCC | 1 |
| Carvalho, AFU | 1 |
| Mota, EF | 1 |
| Garrido-Valdes, M | 1 |
| Díaz-Velis, L | 1 |
| Valdes-Gonzalez, M | 1 |
| Garrido-Suárez, BB | 1 |
| Garrido, G | 1 |
| Duan, L | 1 |
| Bai, Y | 1 |
| Li, M | 1 |
| Li, H | 1 |
| Li, Y | 2 |
| Liu, H | 1 |
| Kulikova, OI | 1 |
| Stvolinsky, SL | 1 |
| Migulin, VA | 1 |
| Andreeva, LA | 1 |
| Nagaev, IY | 1 |
| Lopacheva, OM | 1 |
| Kulichenkova, KN | 1 |
| Lopachev, AV | 1 |
| Trubitsina, IE | 1 |
| Fedorova, TN | 1 |
| Chime, SA | 1 |
| Akpa, PA | 1 |
| Ugwuanyi, CC | 1 |
| Attama, AA | 1 |
| Tang, C | 1 |
| Zhu, Y | 2 |
| Yang, X | 1 |
| Xu, B | 1 |
| Ye, C | 1 |
| Yang, Y | 1 |
| Zhong, J | 1 |
| Zhao, Q | 1 |
| Yu, L | 1 |
| Ahmed, I | 1 |
| Elkablawy, MA | 1 |
| El-Agamy, DS | 1 |
| Bazarbay, AA | 1 |
| Ahmed, N | 1 |
| Bentley-Hewitt, KL | 2 |
| Perrott, M | 1 |
| Butts, CA | 2 |
| Hedderley, DI | 1 |
| Stoklosinski, HM | 1 |
| Parkar, SG | 1 |
| Yang, HJ | 1 |
| Mojkowska, A | 1 |
| Gazdzinski, S | 1 |
| Fraczek, M | 1 |
| Wyleżoł, M | 1 |
| García-Rayado, G | 1 |
| Sostres, C | 2 |
| Lanas, A | 5 |
| Mohamed, HRH | 1 |
| Hamad, SR | 1 |
| Kazmi, I | 1 |
| Saleem, S | 1 |
| Ahmad, T | 1 |
| Afzal, M | 1 |
| Al-Abbasi, FA | 1 |
| Kumar, V | 1 |
| Anwar, F | 1 |
| Patel, VB | 1 |
| Patel, AD | 1 |
| Shah, DA | 1 |
| Verma, S | 1 |
| Kumar, VL | 1 |
| Taha, AS | 2 |
| McCloskey, C | 1 |
| McSkimming, P | 1 |
| McConnachie, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy[NCT05553717] | 66 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| Misoprostol for the Healing of Small Bowel Ulceration in Patients With Obscure Blood Loss While Taking Low-dose Aspirin or Nonsteroidal Antiinflammatory Drugs [MASTERS Trial][NCT02202967] | Phase 3 | 104 participants (Actual) | Interventional | 2016-01-07 | Completed | ||
| Optimal Dose of Proton Pump Inhibitors Following an Upper Gastrointestinal Bleed[NCT02235311] | 3 participants (Actual) | Interventional | 2014-10-31 | Terminated (stopped due to Difficulty recruiting and consenting participants) | |||
| Data-driven Quality Improvement in Primary Care: Cluster Randomised Controlled Trial to Test the Effectiveness of a Multifaceted Intervention in Reducing High Risk Prescribing of Non-steroidal Anti-inflammatory Drugs and Antiplatelet Agents[NCT01425502] | 33 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744] | 101 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| European Registry on the Management of Helicobacter Pylori Infection[NCT02328131] | 10,000 participants (Anticipated) | Observational | 2013-06-30 | Recruiting | |||
| Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study.[NCT00594867] | Phase 4 | 94 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Aspirin Impact on Platelet Reactivity in Acute Coronary Syndrome Patients on Novel P2Y12 Inhibitors Therapy[NCT02049762] | Phase 4 | 29 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| A Randomized, Double-Blind, Phase 3 Study to Compare the Efficacy and Safety of Lansoprazole 30 mg QD and Naproxen 500 mg BID Versus Celecoxib 200 mg QD in Risk Reduction of Non Steroidal Anti-Inflammatory-Associated Ulcers in Osteoarthritis Subjects Taki[NCT00175032] | Phase 3 | 1,045 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| Laparoscopic Revision Gastric Bypass Surgery for Chronic Marginal Ulcers: a 10 Year Experience[NCT01041079] | 50 participants (Actual) | Observational | 2008-12-31 | Completed | |||
| Laparoscopic Revision Gastric Bypass Surgery for Perforated Marginal Ulcer: A 10 Year Experience[NCT01041196] | 30 participants (Actual) | Observational | 2009-01-31 | Completed | |||
| In Vivo Selectivity of Cyclooxygenase Inhibitors in the Oral Surgery Model[NCT00006299] | Phase 2 | 120 participants | Interventional | 1999-12-31 | Completed | ||
| Clinical Study on the Effects of the Product Mucosave® on Gastrointestinal Discomfort and the Quality of Life in Healthy Volunteers[NCT04119817] | 100 participants (Actual) | Interventional | 2019-02-09 | Completed | |||
| Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention[NCT00413309] | 30 participants (Anticipated) | Interventional | 2006-04-30 | Completed | |||
| Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312] | 228 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Open Label, Randomized, Single Site Clinical Trial To Compare The Safety Of Herbal Melanin Extracted From Nigella Sativa Seeds Vs Standard Of Care Treatment In Treating Gastritis Patients[NCT03428568] | Phase 2 | 132 participants (Anticipated) | Interventional | 2018-03-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clostridium difficile confirmed by polymerase chain reaction (PCR) (NCT02235311)
Timeframe: 8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Pantoprazole Twice Daily | 0 |
| Pantoprazole Once Daily | 0 |
As defined by clinical suspicion and/or positive sputum culture requiring antibiotic treatment (NCT02235311)
Timeframe: 8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Pantoprazole Twice Daily | 0 |
| Pantoprazole Once Daily | 0 |
"Per patient report or as defined by follow-up endoscopy per gastroenterology service, 8 weeks after UGIB acute management~High clinical suspicion of rebleed includes melena, hematochezia, confirmed by repeat endoscopy, requiring additional management" (NCT02235311)
Timeframe: 8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Pantoprazole Twice Daily | 0 |
| Pantoprazole Once Daily | 0 |
as defined by follow-up endoscopy per gastroenterology service, 8 weeks after UGIB acute management (NCT02235311)
Timeframe: 8 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Pantoprazole Twice Daily | 1 |
| Pantoprazole Once Daily | 0 |
Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month
| Intervention | participants (Number) |
|---|---|
| Proton Pump Inhibitor Group | 1 |
| Histamine-2 Receptor Antagonist Group | 7 |
Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Histamine-2 Receptor Antagonist Group | 106 |
| Placebo Group | 101 |
79 reviews available for aspirin and Gastric Ulcer
| Article | Year |
|---|---|
Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Fruit; G | 2023 |
Management of Peptic Ulcer Bleeding in Patients Taking Aspirin or Anticoagulant.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Duodenal Ulcer; Helicobacter Infec | 2020 |
Aspirin and omeprazole for secondary prevention of cardiovascular disease in patients at risk for aspirin-associated gastric ulcers.
Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Dose-Response Relationship, Drug; Humans; Omepr | 2017 |
PA32540 for the secondary prevention of cardiovascular disease in patients at risk for aspirin-associated gastric ulcers.
Topics: Aspirin; Cardiovascular Diseases; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors | 2014 |
New insight into the mechanisms of gastroduodenal injury induced by nonsteroidal anti-inflammatory drugs: practical implications.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Duodenal Ulcer; Gastric | 2015 |
Geographic differences in low-dose aspirin-associated gastroduodenal mucosal injury.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asia; Aspirin; Australia; Duodenal Ulcer; Duodenum; Europe; | 2015 |
Drug-disease interactions: narrative review of aspirin in gastric ulcer.
Topics: Aspirin; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Research Design; Stom | 2016 |
Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gastric Mucosa; Humans; | 2009 |
[Pathologic characteristics of gastric ulcer in the aged].
Topics: Aged; Aspirin; Helicobacter Infections; Helicobacter pylori; Humans; Stomach Ulcer | 2010 |
[Differential diagnosis of gastric ulcer and gastric cancer in elderly patients].
Topics: Aged; Aspirin; Diagnosis, Differential; Humans; Stomach Neoplasms; Stomach Ulcer | 2010 |
[Mucoprotective drugs and aspirin-induced gastric injury].
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Famotidine; Huma | 2010 |
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis].
Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinica | 2010 |
Lipoxins, the novel mediators of gastroprotection and gastric adaptation to ulcerogenic action of aspirin.
Topics: Adaptation, Physiological; Aspirin; Humans; Lipoxins; Stomach; Stomach Ulcer | 2011 |
Gastrointestinal effects of aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Gastric Mucosa; Gastroint | 2011 |
Risk and preventive factors of low-dose aspirin-induced gastroduodenal injuries: a comprehensive review.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Duodena | 2012 |
[Novel pharmacological effects of NSAIDs and their molecular mechanism].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2012 |
[Secondary and primary prophylaxis of gastropathy associated with nonsteroidal antiinflammatory drugs or low-dose-aspirin: a review based on four clinical scenarios].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gastrointestinal | 2003 |
[Paracetamol in the treatment of osteoarthritis pain].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 2003 |
[Digestive and hemorrhage complications of low-dose aspirin].
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Co | 2003 |
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: a window of opportunity for cyclooxygenase-inhibiting nitric oxide donors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyc | 2004 |
Review article: prevention of non-steroidal anti-inflammatory drug gastrointestinal complications--review and recommendations based on risk assessment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase 2; Decision Maki | 2004 |
Cardioprotective effects and gastrointestinal risks of aspirin: maintaining the delicate balance.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Ad | 2004 |
Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs--nice or necessary?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Drug Therapy, | 2004 |
Should we eradicate Helicobacter pylori infection in patients receiving nonsteroidal anti-inflammatory drugs or low-dose aspirin?
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; He | 2005 |
Drug-induced side effects affecting the gastrointestinal tract.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Density Conservation Agents; Colitis; Colon; | 2006 |
Building a better aspirin: gaseous solutions to a century-old problem.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemistry, Pharmaceutical; Gastrointestinal Hemorr | 2007 |
Upper GI risks of NSAIDs and antiplatelet agents: key issues for the cardiologist.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiology; Cardiovascular Dise | 2005 |
Strategies to reduce the GI risks of antiplatelet therapy.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiova | 2005 |
Risk factors for gastrointestinal complications in aspirin users: review of clinical and experimental data.
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Risk Factors; Smoking; S | 2008 |
A review of the animal pharmacology of ranitidine--a new, selective histamine H2-antagonist.
Topics: Administration, Oral; Animals; Aspirin; Bethanechol Compounds; Cimetidine; Dogs; Furans; Gastric Aci | 1981 |
Pharmacology of nonsteroidal anti-inflammatory drugs. Practical review for clinicians.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Digestive System; Drug Evaluation, Preclinical; Duodenal | 1983 |
Gastrointestinal effects of antipyretic analgesics.
Topics: Acetaminophen; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bicarbonate | 1983 |
[Gastric manifestations of the side effects of drugs].
Topics: Aspirin; Diagnosis, Differential; Gastric Mucosa; Gastritis; Gastritis, Atrophic; Humans; Stomach Ul | 1984 |
Pathogenesis and pathophysiology of gastric ulcer.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Aspirin; Barium Sulfate; Bile Reflux; Coffee; Duo | 1984 |
Drug therapy: nonsteroidal antiinflammatory drugs (first of two parts).
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Child; Drug Tolerance; Female; Gastric Mucosa; Gastrit | 1980 |
Gastrointestinal toxicity of minor analgesics.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Caffeine; Drug Combinations; Gastroi | 1980 |
[Gastric lesions induced by anti-inflammatory drugs (author's transl)].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Aspirin; Gastrointestinal Hemorrhage; Humans; Pep | 1981 |
Age-associated changes of responses to acetylsalicylic acid.
Topics: Age Factors; Aged; Aspirin; Drug Interactions; Humans; Pain; Stomach Ulcer | 1981 |
Pathogenesis of gastric mucosal injury.
Topics: Animals; Aspirin; Bile Acids and Salts; Bile Reflux; Ethanol; Gastric Juice; Gastric Mucosa; Gastrit | 1982 |
Nonsteroidal anti-inflammatory drug-induced gastric damage: epidemiology.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Humans; M | 1995 |
[Growth factors in experimental ulcer].
Topics: Animals; Aspirin; Chronic Disease; Duodenal Ulcer; Epidermal Growth Factor; Ethanol; Fibroblast Grow | 1994 |
[Aspirin and the gastric mucosa--a new look at an old problem].
Topics: Animals; Aspirin; Gastric Mucosa; Humans; Peptic Ulcer Hemorrhage; Stomach Diseases; Stomach Ulcer | 1993 |
[The epidemiology of the gastroduodenal damage induced by aspirin and other nonsteroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Duodenum; Gastric Mucosa; Humans; | 1997 |
Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1998 |
Role of prostaglandins in gastroprotection.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Gastric Mucosa; Humans; Prostag | 1998 |
Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase Inhibitors | 2001 |
Understanding NSAIDs: from aspirin to COX-2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Human | 2001 |
Risk of gastric injury with enteric- versus nonenteric-coated aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Humans; Randomized Controlle | 2002 |
The biochemical pathology of aspirin-induced gastric damage.
Topics: Age Factors; Alcohol Drinking; Animals; Anti-Inflammatory Agents; Ascorbic Acid Deficiency; Aspirin; | 1975 |
[Digestive complications of corticoid treatment].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aspirin; Colonic Diseases; Duodenal Ulcer; Eso | 1975 |
Side-effects of anti-inflammatory drugs: are they essential or can they be circumvented?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents; Aspirin; Drug Evaluation, Preclinica | 1977 |
The role of the mucosal barrier in drug-induced gastric ulceration and erosions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ethanol; Gastric Juice; Gastric Mucosa; | 1976 |
Progress report. Aspirin in chronic gastric ulcer: an Australian experience.
Topics: Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Self | 1976 |
The pharmacology of tri-potassium di-citrato bismuthate (TDB).
Topics: Animals; Antacids; Aspirin; Bacteria; Bismuth; Cortisone; Digestion; Gastric Mucosa; Histamine; Mice | 1975 |
Analgesics and the stomach.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Indometha | 1976 |
Gastric mucosal damage by aspirin.
Topics: Anemia, Hypochromic; Animals; Aspirin; Cats; Dogs; Ferrets; Gastric Juice; Gastric Mucins; Gastric M | 1975 |
Cost-conscious prescribing of nonsteroidal anti-inflammatory drugs for adults with arthritis. A review and suggestions.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Aspirin; Clinical Prot | 1992 |
[Prostaglandins and damage to the gastric mucosa].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Histamine H2 Antagonists; Humans; | 1991 |
Experimental pathogenesis: drugs and chemical lesions in the gastric mucosa.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Ethanol; Gastric Mucosa; | 1990 |
Aspirin-induced gastric mucosal injury: lessons learned from animal models.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Gastric Mucosa; Prostaglandins; | 1989 |
A review of gastric ulcer and gastroduodenal injury in normal volunteers receiving aspirin and other non-steroidal anti-inflammatory drugs.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenum; Gastric Mucosa; Human | 1989 |
[Effects of gastric proton pump inhibitors on gastric secretion and peptic ulcers].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspi | 1986 |
Gastric blood flow and mucosal defense mechanisms.
Topics: Aminopyrine; Animals; Aspirin; Dogs; Ethanol; Gastric Mucosa; Gastritis; Hydrogen; Microspheres; Sto | 1987 |
NSAID-induced gastric mucosal damage.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Female; Gastric Mucosa; Ga | 1987 |
Aspirin and the stomach.
Topics: Acute Disease; Adaptation, Physiological; Anemia; Animals; Aspirin; Buffers; Chronic Disease; Dose-R | 1986 |
What's new in steroid and nonsteroid drug effects on gastroduodenal mucosa?
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Duodenum; Gastr | 1985 |
Clinical aspects of gastric cytoprotection.
Topics: Administration, Oral; Aluminum; Anti-Inflammatory Agents; Arthritis; Aspirin; Cell Survival; Clinica | 1985 |
[Effect of some drugs in the development and exacerbation of gastric and duodenal ulcer].
Topics: Adrenocorticotropic Hormone; Aspirin; Caffeine; Catecholamines; Duodenal Ulcer; Fluorouracil; Glucoc | 1974 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
Pathophysiology of gastritis: recent concepts and clinical significance.
Topics: Aspirin; Bile; Ethanol; Gastric Mucosa; Gastritis; Gastroesophageal Reflux; Gastroscopy; Humans; Sto | 1972 |
The role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhage.
Topics: Animals; Ascorbic Acid; Aspirin; Blood Coagulation Disorders; Buffers; Dogs; Dosage Forms; Drug Syne | 1973 |
Gastric mucosal barriers.
Topics: Animals; Aspirin; Atropine; Bile Acids and Salts; Cats; Diffusion; Dilatation; Ethanol; Gastric Acid | 1972 |
Gastrointestinal hemorrhage. I. General considerations of diagnosis and the rapy.
Topics: Anus Diseases; Aspirin; Biliary Tract Diseases; Blood Coagulation Disorders; Burns; Child; Child, Pr | 1973 |
Etiology of peptic ulcer.
Topics: Anxiety Disorders; Aspirin; Bile Acids and Salts; Blood Group Antigens; Diet; Duodenal Ulcer; Female | 1974 |
Gastric mucosal injury by anti-inflammatory drugs.
Topics: Acute Disease; Anti-Inflammatory Agents; Aspirin; Chronic Disease; Epithelial Cells; Epithelium; Gas | 1974 |
Peptic ulcer: a review of the recent literature in various clinical aspects. I.
Topics: Adult; Aspirin; Female; Gastric Juice; Humans; Infant, Newborn; Male; Middle Aged; Peptic Ulcer; Sto | 1968 |
Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding.
Topics: Alcohol Drinking; Animals; Ascorbic Acid Deficiency; Aspirin; Gastrointestinal Hemorrhage; Hematemes | 1970 |
[Modern views on peptic ulcers].
Topics: Alcohols; Aspirin; Duodenal Ulcer; Female; Gastric Mucosa; Gastrins; Humans; Male; Parasympatholytic | 1970 |
Acute haemorrhagic gastritis: modern concepts based on pathogenesis.
Topics: Acute Disease; Aspirin; Blood Transfusion; Cell Membrane Permeability; Endoscopy; Gastrectomy; Gastr | 1971 |
52 trials available for aspirin and Gastric Ulcer
| Article | Year |
|---|---|
Upper gastrointestinal mucosal injury associated with ticagrelor plus aspirin, ticagrelor alone, or aspirin alone at 1-year after coronary artery bypass grafting.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Coronary Artery Bypass; Drug Therapy, Combination; Female; F | 2020 |
Misoprostol for small bowel ulcers in patients with obscure bleeding taking aspirin and non-steroidal anti-inflammatory drugs (MASTERS): a randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Double | 2018 |
Endoscopic evaluation of low-dose aspirin-induced gastric and duodenal ulcers during prophylaxis with lansoprazole.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Comorbidity; Double-Blind | 2013 |
Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duodenal Ulcer; Female; Fibrinolytic Agents; | 2014 |
PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: results of two 6-month, phase 3 studies.
Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind | 2014 |
Aspirin Use in Secondary Cardiovascular Protection and the Development of Aspirin-Associated Erosions and Ulcers.
Topics: Adolescent; Adult; Aspirin; Cardiovascular Agents; Cardiovascular Diseases; Disease Progression; Dou | 2016 |
Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon H | 2010 |
Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer | 2011 |
Low-dose aspirin-induced ulceration is attenuated by aspirin-phosphatidylcholine: a randomized clinical trial.
Topics: Acute Disease; Administration, Oral; Aged; Aspirin; Drug Combinations; Female; Humans; Male; Middle | 2011 |
Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duod | 2011 |
Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2012 |
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2004 |
[Prospective comparative study on protective effect of the proton pump inhibitor and the prostaglandin analog on H. pylori-negative gastric mucosa of healthy subjects against low-dose aspirin].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Enzyme I | 2004 |
Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, N | 2004 |
Helicobacter pylori eradication as the sole treatment for gastric and duodenal ulcers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agent | 2005 |
The impact of low-dose aspirin on endoscopic gastric and duodenal ulcer rates in users of a non-selective non-steroidal anti-inflammatory drug or a cyclo-oxygenase-2-selective inhibitor.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Doub | 2006 |
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Metho | 2006 |
Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Double-Blind Method; Drug Therapy | 2008 |
Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovas | 2007 |
Ranitidine in the treatment of gastric ulceration.
Topics: Aged; Alcohol Drinking; Antacids; Anti-Ulcer Agents; Aspirin; Cimetidine; Clinical Trials as Topic; | 1982 |
Resistance to medical therapy of gastric ulcers in rheumatic disease patients taking aspirin. A double-blind study with cimetidine and follow-up.
Topics: Antacids; Aspirin; Cimetidine; Double-Blind Method; Follow-Up Studies; Guanidines; Humans; Placebos; | 1982 |
[A comparison of the gastroduodenal tolerance of ticlopidine and acetylsalicylic acid].
Topics: Adult; Aspirin; Double-Blind Method; Gastric Mucosa; Humans; Male; Purpura; Stomach Diseases; Stomac | 1993 |
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Cross-Over S | 1997 |
Primary amino-bisphosphonates: a new class of gastrotoxic drugs--comparison of alendronate and aspirin.
Topics: Adult; Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Esophagus | 1997 |
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase Inhibitors | 1998 |
Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenas | 1999 |
Low-dose misoprostol for the prevention of low-dose aspirin-induced gastroduodenal injury.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duo | 2000 |
Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Fem | 2000 |
A randomized controlled trial to assess alendronate-associated injury of the upper gastrointestinal tract.
Topics: Adult; Alendronate; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinopros | 2000 |
Placebo-controlled, randomized, evaluator-blinded endoscopy study of risedronate vs. aspirin in healthy postmenopausal women.
Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy, Gastrointestinal; Esophagus; Etidronic Acid; Female | 2000 |
Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial.
Topics: Adolescent; Adult; Antibodies, Bacterial; Aspirin; Blood Platelets; Cyclooxygenase 1; Double-Blind M | 2001 |
Gastric ulcer, aspirin esterase and aspirin.
Topics: Aspirin; Clinical Trials as Topic; Esterases; Ethanol; Female; Gastric Mucosa; Humans; Male; Methods | 1977 |
Double-blind study of Naproxen in osteoarthritis of the knee joint.
Topics: Activities of Daily Living; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; C | 1976 |
A comparison of a new slow release aspirin ("slow aspirin") with plain aspirin in the treatment of rheumatoid disease.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Delayed-Action Preparations; Double-Blind Method; Drug | 1977 |
Protection against aspirin-induced gastric lesions by lansoprazole: simultaneous evaluation of functional and morphologic responses.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Analysis of Variance; Anti-Ulcer Agents; Aspirin; Do | 1992 |
Ranitidine: differential effects on gastric bleeding and mucosal damage induced by aspirin.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastric Mucosa; Gastr | 1992 |
Separation of the impairment of haemostasis by aspirin from mucosal injury in the human stomach.
Topics: Adult; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Drug Administration Schedule; Female | 1991 |
Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding.
Topics: Adult; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control | 1991 |
Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control | 1991 |
Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers.
Topics: Adult; Aspirin; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Helic | 1991 |
A report of three multiclinic trials evaluating arbaprostil in arthritic patients with ASA/NSAID gastric mucosal damage. The Upjohn Company Arbaprostil ASA/NSAID Gastric Mucosal Damage Treatment Study Groups.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aluminum Hydroxide; Anti-Inflammatory Agents, | 1990 |
The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations.
Topics: Adult; Aged; Aspirin; Double-Blind Method; Duodenal Ulcer; Female; Follow-Up Studies; Hospitalizatio | 1990 |
Chronic beta-carotene supplementation does not alter the gastric mucosal response to acute aspirin ingestion.
Topics: Acute Disease; Aged; Aspirin; beta Carotene; Carotenoids; Double-Blind Method; Female; Gastric Mucos | 1990 |
Misoprostol reduces gastroduodenal injury from one week of aspirin: an endoscopic study.
Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Clinical Trials as Topic; Double-Blind M | 1989 |
Prevention of non-steroidal anti-inflammatory agents induced acute gastric mucosal lesions by carbonic anhydrase inhibitors. An endoscopic study.
Topics: Acetazolamide; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastroscopy; | 1989 |
Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin.
Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cimetidine; Drug Therapy, Combination; G | 1989 |
The effect of dietary fatty acids on the gastric production of prostaglandins and aspirin-induced injury.
Topics: Adult; Aspirin; Dietary Fats; Fatty Acids; Gastric Mucosa; Humans; Prostaglandins; Stomach Ulcer | 1988 |
[Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine].
Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Clinical Trials as Topic; Double-Bli | 1986 |
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study].
Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspiri | 1987 |
[Endoscopic study of gastric tolerance of paracetamol and acetylsalicylic acid. A placebo-controlled double-blind study on healthy subjects].
Topics: Acetaminophen; Adult; Aspirin; Double-Blind Method; Duodenum; Gastroscopy; Humans; Male; Random Allo | 1988 |
[Protective effect of two antacids in acute acetylsalicylic acid-induced injuries to the human gastric mucosa].
Topics: Adult; Antacids; Aspirin; Clinical Trials as Topic; Double-Blind Method; Gastric Mucosa; Humans; Mal | 1985 |
Clinical aspects of gastric cytoprotection.
Topics: Administration, Oral; Aluminum; Anti-Inflammatory Agents; Arthritis; Aspirin; Cell Survival; Clinica | 1985 |
716 other studies available for aspirin and Gastric Ulcer
| Article | Year |
|---|---|
Glycerides as prodrugs. 1. Synthesis and antiinflammatory activity of 1,3-bis(alkanoyl)-2-(O-acetylsalicyloyl)glycerides (aspirin triglycerides).
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Do | 1979 |
Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1992 |
3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Drug Evaluation, Preclini | 1984 |
Glycerides as prodrugs. 2. 1,3-Dialkanoyl-2-(2-methyl-4-oxo-1,3-benzodioxan-2-yl)glycerides (cyclic aspirin triglycerides) as antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Edema; Male; Rats; Salicylates; Stomach Ulc | 1980 |
Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles.
Topics: Animals; Blood Platelets; Cyclooxygenase Inhibitors; Guinea Pigs; Male; Malondialdehyde; Molecular S | 1994 |
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Cyclooxygenase 1; Cyclooxy | 2005 |
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.
Topics: Analgesics; Anilides; Animals; Benzenesulfonates; Carrageenan; Colorimetry; Crystallography, X-Ray; | 2007 |
Preparation of 5-aryl-3-alkylthio-l,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Mice; Molecular Structure; Stomach Ulcer; Sulfones; T | 2007 |
Synthesis and crystallographic analysis of benzophenone derivatives--the potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Carrageenan; Crystallography, X-Ray | 2007 |
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloo | 2007 |
Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azo Compounds; Carr | 2008 |
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic | 2009 |
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclo | 2014 |
Preparation and preliminary quality evaluation of aspirin/L-glutamate compound pellets.
Topics: Animals; Aspirin; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Dru | 2021 |
Protective effects of Dialium guineense pulp on aspirin-induced gastric mucosal injury in albino rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Fabaceae; Gastric Mucosa; Humans; Plant Extracts; | 2021 |
Spirulina supplements: an approach moderating aspirin persuaded histological and ultra-structural alterations in albino rats gastric mucosa.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Male; Rats; Spirulina; St | 2022 |
Analagesic and Anti-Inflammatory Potentials of a Less Ulcerogenic Thiadiazinethione Derivative in Animal Models: Biochemical and Histochemical Correlates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Car | 2022 |
Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: results from two large cohorts with new-user design.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Human | 2022 |
Editorial: risk of gastric and duodenal ulcers among new users of low-dose aspirin.
Topics: Aspirin; Duodenal Ulcer; Humans; Stomach Ulcer | 2022 |
Analysis of antidiabetic, antiulcer and analgesic potential of traditional ethnomedicinal plant Emex spinosa (L.) Campd. from Azad Jammu and Kashmir.
Topics: Analgesics; Animals; Anti-Ulcer Agents; Aspirin; Blood Glucose; Ethanol; Flavonoids; Formaldehyde; H | 2022 |
Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.
Topics: Acetaminophen; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Chemical and Drug Induced Liver In | 2022 |
Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin
Topics: Aloe; Animals; Anti-Anxiety Agents; Antioxidants; Aspirin; Female; Geranium; Plant Extracts; Powders | 2023 |
In vitro anti-inflammatory activity and ameliorative effects on gastric ulcers of Licania rigida benth seed extract.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Aspirin; Chrysobalanaceae; Ethan | 2023 |
Increased risk of aspirin-induced gastric mucosal erosion in elderly Chinese men harboring SLCO1B1*1b/*1b while using aspirin and an ACEI or ARB concomitantly.
Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 2019 |
A new derivative of acetylsalicylic acid and carnosine: synthesis, physical and chemical properties, biological activity.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Carnosine; Erythrocytes; Hemolysis; | 2020 |
Anti-Inflammatory and Gastroprotective Properties of Aspirin - Entrapped Solid Lipid Microparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Availability; Chemistry, Pharm | 2020 |
Carvedilol safeguards against aspirin-induced gastric damage in rats.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin | 2020 |
Influence of kiwifruit on gastric and duodenal inflammation-related gene expression in aspirin-induced gastric mucosal damage in rats.
Topics: Actinidia; Animals; Aspirin; CLOCK Proteins; Duodenum; Fruit; Gastric Mucosa; Gene Expression Regula | 2020 |
Gastric Ulcer Hemorrhage - a Potential Life-Threatening Complication of Intragastric Balloon Treatment of Obesity.
Topics: Adult; Aspirin; Bariatric Surgery; Gastric Balloon; Gastrointestinal Hemorrhage; Helicobacter Infect | 2017 |
Nullification of aspirin induced gastrotoxicity and hepatotoxicity by prior administration of wheat germ oil in Mus musculus: histopathological, ultrastructural and molecular studies.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Agen | 2017 |
Protective effect of oleane-12-en-3β-ol-28-oic acid 3β-D-glucopyranoside in ethanol induced gastric ulcer by enhancing the prostaglandin E2 level.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Dinoprostone; Ethanol; | 2018 |
Stability Indicating Liquid Chromatographic Method for Simultaneous Determination of Aspirin and Omeprazole.
Topics: Aspirin; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Combinations; Drug Co | 2018 |
Artesunate affords protection against aspirin-induced gastric injury by targeting oxidative stress and proinflammatory signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Artemisinins; Artesunate; Aspir | 2018 |
The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior.
Topics: Animals; Anxiety; Aspirin; Behavior, Animal; Female; Humans; Interleukin-4; Interleukin-6; Male; Mic | 2018 |
Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Edema; Gastric Mucosa; Gastrointestinal Agents; G | 2018 |
Gastroduodenal ulcer bleeding in elderly patients on low dose aspirin therapy.
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebrovascu | 2018 |
Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Inflammation; Male; Mice; O | 2019 |
Comparative outcomes in patients with ulcer- vs non-ulcer-related acute upper gastrointestinal bleeding in the United Kingdom: a nationwide cohort of 4474 patients.
Topics: Aged; Aged, 80 and over; Aspirin; Cohort Studies; Female; Gastrointestinal Hemorrhage; Hospital Mort | 2019 |
Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cimetidine; Cytoprotection; Disease Models, Anima | 2019 |
Involvement of the anti-inflammatory, anti-apoptotic, and anti-secretory activity of bee venom in its therapeutic effects on acetylsalicylic acid-induced gastric ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Aspirin; bcl-2-Associ | 2019 |
Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats.
Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Gastric Mucosa; Gene Expression; Ma | 2019 |
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats.
Topics: Animals; Aspirin; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Gastric | 2019 |
The use of prophylactic gastroprotective therapy in patients with nonsteroidal anti-inflammatory drug- and aspirin-associated ulcer bleeding: a cross-sectional study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cross- | 2013 |
Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Acid; G | 2013 |
[Study on efficacy and mechanism of weiyangning pills against experimental gastric ulcer].
Topics: Acetic Acid; Animals; Aspirin; Dinoprostone; Drugs, Chinese Herbal; Epidermal Growth Factor; Female; | 2013 |
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine | 2014 |
NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4(+)VEGFR1(+) cells to the ulcer granulation tissues.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemokine CXCL12; Enzyme Pre | 2013 |
Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers.
Topics: Alcohols; Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cold Temperature; Disease Mo | 2013 |
Relationship between continuous use of low-dose enteric-coated aspirin and gastrointestinal injuries in patients with gastrointestinal hemorrhage.
Topics: Aspirin; Case-Control Studies; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastrointestinal | 2013 |
The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection.
Topics: Adenoma; Aged; Anti-Ulcer Agents; Anticoagulants; Aspirin; Carcinoma; Case-Control Studies; Clopidog | 2013 |
Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study.
Topics: Animals; Aspirin; Benzyl Alcohols; Drug Evaluation, Preclinical; Female; Gastric Mucosa; Male; Nitro | 2014 |
Low-dose aspirin-associated upper gastric and duodenal ulcers in Japanese patients with no previous history of peptic ulcers.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Asian People; Aspirin; Diabetes Complications; Diabetes | 2013 |
Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzyl Alcohols; Cyclooxygenase 1; Cycloo | 2014 |
Prostaglandin analogous and antioxidant activity mediated gastroprotective action of Tabernaemontana divaricata (L.) R. Br. flower methanolic extract against chemically induced gastric ulcers in rats.
Topics: Animals; Antioxidants; Aspirin; Catalase; Ethanol; Flowers; Male; Malondialdehyde; Methanol; Mucins; | 2013 |
Is enteric aspirin safer than regular aspirin?
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, | 2013 |
In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br.
Topics: Animals; Anti-Allergic Agents; Anti-Bacterial Agents; Anti-Ulcer Agents; Antioxidants; Aspirin; Chro | 2014 |
Low-dose aspirin and comorbidities are significantly related to bleeding peptic ulcers in elderly patients compared with nonelderly patients in Japan.
Topics: Adolescent; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, | 2014 |
Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Female; Lecythidaceae; Male; Plant Extracts; Plant Leaves; Rats | 2014 |
Involvement of glutamate-cystine/glutamate transporter system in aspirin-induced acute gastric mucosa injury.
Topics: Amino Acid Transport System X-AG; Amino Acid Transport System y+; Animals; Anti-Inflammatory Agents, | 2014 |
Identification of a high-risk group for low-dose aspirin-induced gastropathy by measuring serum pepsinogen in H. pylori-infected subjects.
Topics: Aged; Aged, 80 and over; Antibodies, Bacterial; Aspirin; Biomarkers; Drug Administration Schedule; F | 2015 |
Apple polyphenol extracts protect against aspirin-induced gastric mucosal damage in rats.
Topics: Animals; Aspirin; Chlorogenic Acid; Flavonoids; Gastric Mucosa; Male; Malus; Plant Extracts; Polyphe | 2014 |
PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin - authors' reply.
Topics: Anti-Ulcer Agents; Aspirin; Duodenal Ulcer; Female; Fibrinolytic Agents; Humans; Male; Rabeprazole; | 2014 |
PPI vs. teprenone in preventing recurrence of ulcers during low-dose aspirin.
Topics: Anti-Ulcer Agents; Aspirin; Duodenal Ulcer; Female; Fibrinolytic Agents; Humans; Male; Rabeprazole; | 2014 |
Identification of quinoline-chalcone hybrids as potential antiulcer agents.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Chalcone; Disease Models, Animal; Dose-Re | 2015 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gas | 2014 |
The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies.
Topics: Animals; Anti-Ulcer Agents; Aspirin; bcl-2-Associated X Protein; Disease Models, Animal; Gastric Muc | 2015 |
Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Cyperus; | 2015 |
Endoscopic application of polysaccharide powder for hemostasis in anticoagulated pigs (with video).
Topics: Animals; Anticoagulants; Aspirin; Hemostasis, Endoscopic; Hemostatics; Heparin; Peptic Ulcer Hemorrh | 2015 |
The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced PepticUlcers in a Korean Ethnic Group.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Sectional Studies; Cyclooxygenase 1; D | 2016 |
Histopathological evaluation of gastro protective effect of Berberis vulgaris (Zereshk) seeds against aspirin induced ulcer in albino mice.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Berberis; Cell Proliferatio | 2015 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Gastroprotective Effect of Combination of Hot Water Extracts of Licorice (Glycyrrhiza glabra), Pulasari Stem Bark (Alyxia reinwardtii), and Sembung Leaf (Blumea balsamifera) Against Aspirin-Induced Gastric Ulcer Model Rats.
Topics: Animals; Apocynaceae; Aspirin; Asteraceae; Gastric Mucosa; Glycyrrhiza; Male; Plant Extracts; Protec | 2016 |
Co-lyophilized Aspirin with Trehalose Causes Less Injury to Human Gastric Cells and Gastric Mucosa of Rats.
Topics: Animals; Apoptosis; Aspirin; Caspase 3; Cell Line, Tumor; Epithelial Cells; Freeze Drying; Gastric M | 2016 |
Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid-induced gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Benzoquinones; Biomarkers; Gas | 2016 |
Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line; Cyclooxygenase 1; C | 2016 |
Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Catechols; Cell Li | 2017 |
The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Dose-Response Relationship, | 2008 |
Proton pump inhibitors reduce the long-term risk of recurrent upper gastrointestinal bleeding: an observational study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; | 2008 |
Protective role of ascorbic acid isolated from Cissus quadrangularis on NSAID induced toxicity through immunomodulating response and growth factors expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Cissus; Cytokines; Gastric | 2008 |
Melatonin and its precursor L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans.
Topics: Acute Disease; Adult; Aspirin; Dose-Response Relationship, Drug; Free Radical Scavengers; Gastric Mu | 2008 |
Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Immersion; Lipid Peroxida | 2008 |
Effect of ripe fruit pulp extract of Cucurbita pepo Linn. in aspirin induced gastric and duodenal ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cucurbita; Duodenal Ulcer; Female; Fruit; Male; Plant Extracts; | 2008 |
Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease.
Topics: Aged; Aspirin; Case-Control Studies; Drug Administration Schedule; Duodenal Ulcer; Duodenoscopy; Fem | 2008 |
[Bleeding peptic ulcer. Prevalence of Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs/acetylsalicylic acid].
Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Femal | 2009 |
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Disease Models, Animal; Edema; F | 2009 |
Predictors of gastroduodenal erosions in patients taking low-dose aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Endoscopy; Femal | 2010 |
Synthesis and analgesic and anti-inflammatory activity of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives.
Topics: Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoqu | 2009 |
Effect of methanolic extract of Pongamia pinnata Linn seed on gastro-duodenal ulceration and mucosal offensive and defensive factors in rats.
Topics: Acetic Acid; Animals; Aspirin; Catalase; Chromatography, Thin Layer; Cold Temperature; Duodenal Ulce | 2009 |
Effect of fucoidan on aspirin-induced stomach ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Blood Urea Nitrogen; G | 2010 |
Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Arginine; As | 2009 |
Anti-ulcer role of herbomineral Siddha drug - Thamira parpam on experimentally induced gastric mucosal damage in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Body Weight; Cytoprotection; Disease Models, Anim | 2010 |
Prevalence of Helicobacter pylori infection in duodenal ulcer and gastro-duodenal ulcer diseases in Taiwan.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breath Tests; | 2010 |
Compliance with guidelines for proton pump inhibitor prescriptions in a department of geriatrics.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Prescriptions; Femal | 2009 |
Novel conjugates of aspirin with phenolic acid as anti-inflammatory agents having significantly reduced gastrointestinal toxicity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aspirin; Biphenyl Compounds; Croton Oil; Disease Mo | 2010 |
Gastroprotective effect of earthworm paste (Lampito mauritii, Kinberg) on experimental gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cytoprotection; Disease Models, Animal; Dose-Response Relations | 2010 |
Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action.
Topics: Acetylcholine; Animals; Aspirin; Atropine; Cholinergic Antagonists; Cimetidine; Ethanol; Flax; Gastr | 2010 |
Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans.
Topics: Adult; Aspirin; Dinoprostone; Gastric Mucosa; Gastrins; Gastrointestinal Hemorrhage; Humans; Male; M | 2010 |
Investigation of gastroduodenal mucosal injuries caused by low-dose aspirin therapy in patients with cerebral infarction.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Cardiovascular Agents; Cerebral Infarction; Chi | 2010 |
Impact of upper gastrointestinal lesions in patients on low-dose aspirin therapy: preliminary study.
Topics: Aged; Aspirin; Cardiovascular Agents; Duodenal Ulcer; Endoscopy, Digestive System; Esophageal Neopla | 2010 |
[Gastroprotective properties of mexidol and hypoxen].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Gastric Mucosa; Phenyl Ethe | 2010 |
Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn).
Topics: alpha-L-Fucosidase; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2010 |
Moringa oleifera induced potentiation of serotonin release by 5-HT(3) receptors in experimental ulcer model.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Enterochromaffin Cells; Female; Male; M | 2011 |
Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antipyretics; Aspirin; Dinoprostone; | 2010 |
Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats.
Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Drug; Lipid P | 2010 |
Interactive medical case. Bitter pills.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biopsy; Creatini | 2010 |
[Risk factors for development and recurrence of peptic ulcer disease].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Endoscopy, Gastrointestinal; Female; | 2010 |
Clinical problem-solving. Bitter pills.
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Diagnosis, Di | 2010 |
[Pathogenic mechanism of aspirin-induced gastric ulceration and its characteristics].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Humans; Stomach Ulcer | 2010 |
[Prophylaxis and treatment of gastric ulcer by low-dose aspirin in the aged].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Proton Pump Inhibitors; Stomach Ulce | 2010 |
[Significance of H. pylori eradication in treatment and prevention for low-dose aspirin induced gastric ulcer of elderly].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Helicobacter Infections; Helicobacter pylori | 2010 |
Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Collagen; Cyclooxygena | 2011 |
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ather | 2011 |
Anti-ulcer constituents of Annona squamosa twigs.
Topics: Animals; Annona; Anti-Ulcer Agents; Aporphines; Aspirin; Benzylisoquinolines; Berberine Alkaloids; C | 2011 |
Gastroprotective effect of small centaury (Centaurium erythraea L) on aspirin-induced gastric damage in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Aspirin; Centaurium; Male; Peroxidase; Plant Extracts; | 2011 |
Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats.
Topics: Animals; Aspirin; Cimetidine; Honey; Humans; Male; Nigella sativa; Phytotherapy; Rats; Seeds; Stomac | 2011 |
Gastric mucosal damage evaluated by transnasal endoscopy and QOL assessments in ischemic heart disease patients receiving low-dose aspirin.
Topics: Aged; Aspirin; Endoscopy, Digestive System; Female; Gastric Mucosa; Health Surveys; Humans; Male; Mi | 2011 |
Effect of probiotics on aspirin-induced gastric mucosal lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Degranulation; Gastric Lavage; Gastr | 2011 |
[Warm-needle moxibustion therapy may reduce aspirin-induced gastric mucosal injury in rats].
Topics: Animals; Aspirin; Female; Gastric Mucosa; Humans; Male; Malondialdehyde; Moxibustion; Random Allocat | 2011 |
Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Carrageenan; Cell Line, Tum | 2012 |
Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Butanols; Catalase; Convolvulaceae; Cytoprotection; Disease Mod | 2011 |
[Prevention and treatment of low-dose aspirin induced gastric ulcer in coronary artery disease after coronary intervention].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Disease; Humans; Stomach Ulcer | 2011 |
Spontaneous remission of Schnitzler syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Histamine Antagonists; Humans; Immunoglobulin G; I | 2011 |
Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models.
Topics: Acids; Animals; Anti-Ulcer Agents; Aspirin; Biphenyl Compounds; Disease Models, Animal; Ethanol; Fre | 2012 |
Endoscopic and clinical features of gastric ulcers in Japanese patients with or without Helicobacter pylori infection who were using NSAIDs or low-dose aspirin.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asian People; Aspirin; Case | 2012 |
Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Arbutin; Aspirin; Cell Line; Cytoprotection; Disease Model | 2012 |
Psidium guajava Linn confers gastro protective effects on rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Central Nervous System | 2012 |
Gastric injury caused by low-dose aspirin therapy in consecutive Japanese patients: a prospective study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Antibodies, Bacterial; Asia | 2012 |
A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Interactions; Famotidine; Gastric Acid; Gastr | 2012 |
Correlation between Helicobacter pylori infection and low-dose aspirin use on damage of the upper gastrointestinal tract.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chi-Square Distributio | 2012 |
Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbohydrate Metabolism; Cell Proliferation; Cold Temperature; | 2012 |
Pharmacological evaluation of fruits of Terminalia belerica Roxb. for antiulcer activity.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Biomarkers; Cold Temperature; Disease Models, Animal; Dose-Resp | 2012 |
Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.
Topics: Acrolein; Animals; Anti-Ulcer Agents; Aspirin; Cinnamomum zeylanicum; Disease Models, Animal; Drugs, | 2013 |
Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants.
Topics: Animals; Antioxidants; Aspirin; Biomarkers; Catalase; Diabetes Mellitus, Experimental; Dose-Response | 2012 |
Evaluation of antiulcer activity of indole-3-carbinol and/or omeprazole on aspirin-induced gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cyclooxygenase 2; Indoles; Male; Omeprazole; Rats; Stomach; Sto | 2014 |
H(2)S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress.
Topics: Animals; Aspirin; Cyclooxygenase 2; Delayed-Action Preparations; Dinoprostone; Disulfides; Dose-Resp | 2012 |
Orally administered phosphatidic acids and lysophosphatidic acids ameliorate aspirin-induced stomach mucosal injury in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Evaluation, Pr | 2013 |
Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aspirin; Cell Cycle; Cell Proliferation; Chromatography, | 2013 |
Gastroprotective activity of ethanolic root extract of Potentilla fulgens Wall. ex Hook.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Catalase; Cold Temperature; DNA; Ethanol; Female; Glutathione; | 2013 |
[Coxib spares the stomach. This is true also for patients with preventive aspirin administration].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Celecoxib; Drug Therapy, Co | 2002 |
[Deficit of glucocorticoid production in rats aggravates ulcerogenic effects of stimuli of various modality and intensity].
Topics: Acetic Acid; Adrenalectomy; Animals; Aspirin; Corticosterone; Ethanol; Glucocorticoids; Hormone Repl | 2002 |
Can the diagnosis of NSAID-induced or Hp-associated gastric ulceration be predicted from histology?
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Comorbidity; Diagnosis, Differential | 2002 |
Effect of Helicobacter pylori on delay in ulcer healing induced by aspirin in rats.
Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Gastric Acid; Gene Expression; Helicobacter py | 2002 |
Aggravation of nonsteroidal antiinflammatory drug gastropathy by glucocorticoid deficiency or blockade of glucocorticoid receptors in rats.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corticosterone; Drug Syner | 2002 |
Gastroprotective effect of beta3 adrenoreceptor agonists ZD 7114 and CGP 12177A in rats.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, No | 2002 |
Might proton pump inhibitors prevent the antiplatelet effects of low- or very low-dose aspirin?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biological Availability; Humans | 2002 |
Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.
Topics: Animals; Aspirin; Carbohydrates; Ethanol; Female; Fructose; Glucose; Honey; Indomethacin; Male; Malt | 2002 |
Effects of the anti-ulcer agents ecabet sodium, cimetidine and sucralfate on acetylsalicylic acid-induced gastric mucosal damage deteriorated by renal failure in rats.
Topics: Abietanes; Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2002 |
Comparative effects of a tocotrienol-rich fraction and tocopherol in aspirin-induced gastric lesions in rats.
Topics: Animals; Antioxidants; Aspirin; Gastric Acid; Gastric Mucosa; Lipid Peroxidation; Male; Malondialdeh | 2002 |
The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions.
Topics: Aldehydes; Animals; Aspirin; Gastric Mucosa; Lipid Peroxidation; Male; Malondialdehyde; Molsidomine; | 2002 |
Effect of amitriptyline on gastric ulceration.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Aspirin; Col | 2002 |
[Anti-gastric ulcer sesquiterpene lactone glycosides from Crepis napifera].
Topics: Animals; Anti-Ulcer Agents; Aspirin; Crepis; Disease Models, Animal; Female; Gastric Acid; Gastric M | 2002 |
[When the cardiac patient with arthritis needs aspirin and NSAID: how to protect the stomach?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Celecoxi | 2003 |
[In high risk patients cyclooxygenase inhibitor plus proton pump inhibitor].
Topics: Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Coronary Disease; Cyclooxygenase 2; Cyclooxygenas | 2003 |
Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion; Cyclooxygenase 2; Cyclooxy | 2003 |
Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Carbohydrate Metabolis | 2003 |
Effect of various doses of palm vitamin E and tocopherol on aspirin-induced gastric lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Gastric | 2002 |
Synthesis of vanillin ethers from 4-(bromomethyl) coumarins as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzaldehydes; Carrageenan; Coumarins; Ed | 2003 |
Protective effects of polygodial on gastric mucosal lesions induced by necrotizing agents in rats and the possible mechanisms of action.
Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Gastrointestinal Agents; Hydrochloric Acid; Indomethacin; | 2003 |
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno | 2003 |
Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weight; | 2003 |
Antiinflammatory and antiulcer activities of Bambusa arundinacea.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Bambusa; Carrageenan; | 2003 |
[Severe hematemesis caused by acute gastric ulceration following massive absorption of aspirin].
Topics: Aspirin; Hematemesis; Humans; Stomach Diseases; Stomach Ulcer | 1959 |
Aspirin and chronic gastric ulcer.
Topics: Aspirin; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Stomach Ulcer | 1961 |
Recurrent gastric ulcer with spontaneous gastrojejunal and gastrocolic fistulas. Report of a case.
Topics: Aspirin; Colonic Diseases; Cortisone; Gastric Fistula; Humans; Intestinal Fistula; Prednisone; Stoma | 1963 |
[PERFORATED GASTRIC ULCER AS A COMPLICATION OF ACTH AND ASPIRIN THERAPY].
Topics: Adrenocorticotropic Hormone; Aspirin; Humans; Optic Neuritis; Peptic Ulcer Perforation; Stomach Ulce | 1963 |
CHRONIC GASTRIC ULCER ASSOCIATED WITH ASPIRIN INGESTION. A REPORT OF 5 CASES AND REVIEW OF THE LITERATURE.
Topics: Aspirin; Pathology; Radiography; Stomach Ulcer; Toxicology | 1963 |
THE GASTRIC ANTIULCER ACTIVITY OF CHLORBENZOXAMINE, A NON-ANTICHOLINERGIC PIPERAZINE COMPOUND.
Topics: Aspirin; Benzyl Compounds; Cholinergic Antagonists; Gastric Juice; Hypophysectomy; Pharmacology; Pip | 1963 |
ANAEMIA ASSOCIATED WITH UNEXPLAINED OCCULT BLOOD LOSS.
Topics: Anemia; Anemia, Hypochromic; Aspirin; Diagnosis, Differential; Guaiac; Hemorrhoids; Humans; Iron; Li | 1964 |
[EXPERIMENTAL STUDY OF GASTRIC TOLERANCE TO CORTICOID-ASPIRIN COMBINATIONS].
Topics: Adrenal Cortex Hormones; Aspirin; Betamethasone; Dermatologic Agents; Dexamethasone; Methylprednisol | 1963 |
EFFECT OF ACETYLSALICYLIC ACID ON FOETAL RATS.
Topics: Abnormalities, Drug-Induced; Aspirin; Caseins; Fetus; Pharmacology; Pregnancy; Rats; Research; Reser | 1964 |
STUDIES ON THE BIOCHEMICAL MECHANISM OF THE GASTRIC EROSION CAUSED BY ASPIRIN.
Topics: Animals; Aspirin; Enzyme Precursors; Gastric Acidity Determination; Gastric Mucosa; Guinea Pigs; His | 1964 |
THE GASTRIC MUCOSA IN RADIOLOGICALLY NEGATIVE ACUTE GASTROINTESTINAL BLEEDING.
Topics: Aspirin; Biopsy; Duodenal Ulcer; Gastric Acidity Determination; Gastric Mucosa; Gastritis; Gastroint | 1964 |
[MEDICINAL ULCERS OF THE GREATER CURVATURE OF THE STOMACH].
Topics: Adrenal Cortex Hormones; Aspirin; Drug Therapy; Radiography; Stomach Ulcer; Toxicology; Ulcer | 1965 |
Nitric oxide-releasing aspirin protects gastric mucosa against ethanol damage in rats with functional ablation of sensory nerves.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Capsaicin; Ethanol; Ga | 2003 |
Synthesis, characterization and antiinflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo [3,2-b]-1,2,4-triazol-5-ols.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Capillary Per | 2004 |
Upper gastrointestinal haemorrhage following cardiac surgery: a comparative study with vascular surgery patients from a single centre.
Topics: Aged; Aspirin; Cardiac Surgical Procedures; Coronary Artery Bypass; Duodenal Ulcer; Female; Gastroin | 2004 |
Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Aspirin; Azadirachta; Bacopa; Cold Temperature; Diabetes Me | 2004 |
Antiulcer activity of Utleria salicifolia rhizome extract.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Dose-Response | 2004 |
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cysteamine; Duodenal | 2004 |
The healing effect of TGF-alpha on gastric ulcer induced by acetylsalicylic acid in rats.
Topics: Animals; Aspirin; Gastric Mucosa; Injections, Intralesional; Male; Mice; Rats; Rats, Wistar; Stomach | 2004 |
Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Duodenal Ulcer; Ethanol; Female; Guinea Pigs; Histamine; Male; | 2004 |
Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats.
Topics: Acetic Acid; Animals; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ul | 2003 |
Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Celecoxib; Cyclooxygenase 1; Cy | 2004 |
[Helicobacter pylori: changes of indications for eradication therapy].
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Aspirin; Drug Therapy, Combination; Gastroesophageal Reflu | 2004 |
Drug-induced upper gastrointestinal disorders requiring hospitalization: a five-year study in a South Indian hospital.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug-Related Side Effects a | 2004 |
The role of transforming growth factor alpha formulation on aspirin-induced ulcer healing and oxidant stress in the gastric mucosa.
Topics: Analysis of Variance; Animals; Aspirin; Biomarkers; Disease Models, Animal; Gastric Mucosa; Glutathi | 2004 |
The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Ethanol; Fruit; Gastric Mucosa; Lipid Peroxidatio | 2005 |
Effect of vitamin C-releasing acetylsalicylic acid on gastric mucosal damage before and after Helicobacter pylori eradication therapy.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Blotting, Wester | 2004 |
Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor.
Topics: Animals; Aspirin; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Effect of ambrex (an amber based formulation) on gastric mucosal damage: role of antioxidant enzymes and lipid profile.
Topics: Amber; Animals; Antioxidants; Aspirin; Gastric Mucosa; Male; Plants, Medicinal; Rats; Stomach Ulcer | 2004 |
Endoscopy in asymptomatic minidose aspirin consumers.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationshi | 2005 |
Antiulcerogenic effect of Justicia prostrata Gamble.
Topics: Acanthaceae; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Dose-Response Relationship | 2005 |
Allophylus serratus: a plant with potential anti-ulcerogenic activity.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Cold Temperature; Disease Models, Animal; | 2005 |
The protective effects of rutaecarpine on gastric mucosa injury in rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Evodia; Female; Gastric Muco | 2005 |
Influence of gastric colonization with Candida albicans on ulcer healing in rats: effect of ranitidine, aspirin and probiotic therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biopsy; Blood Flow Vel | 2005 |
Desmodium gangeticum: a potent anti-ulcer agent.
Topics: Alcohols; Animals; Anti-Ulcer Agents; Aspirin; Cold Temperature; Duodenal Ulcer; Ethanol; Fabaceae; | 2005 |
Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells.
Topics: Actins; Animals; Aspirin; Cell Movement; Cells, Cultured; Cytoskeleton; Ethanol; Gastric Mucosa; Rat | 2005 |
Protective role of heat shock protein 27 in gastric mucosal injury.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; | 2005 |
Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin.
Topics: Aged; Aspirin; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Humans; Incidence; Male; Middle | 2005 |
Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Drug; Elettaria; Ethanol; Fruit; Ga | 2006 |
Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cissus; Dose-Response Relationship, Drug; Lipid P | 2006 |
Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug.
Topics: Abdominal Pain; Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
Antiulcer and antimicrobial activity of Anogeissus latifolia.
Topics: Animals; Anti-Infective Agents; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroida | 2006 |
Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Dipyrida | 2006 |
[Gastric protection and treatment with low-dose aspirin].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; | 2006 |
Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cissus; Cytokines; Dis | 2005 |
Upper gastrointestinal bleeding after hip and knee arthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthroplast | 2006 |
ACEA (arachidonyl-2-chloroethylamide), the selective cannabinoid CB1 receptor agonist, protects against aspirin-induced gastric ulceration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; Aspirin; Dos | 2006 |
Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study.
Topics: Aged; Aspirin; Case-Control Studies; Drug Therapy, Combination; Female; Fibrinolytic Agents; Gastroi | 2006 |
The use of nonsteroidal anti-inflammatory drugs and the occurrence of gastric lesions among patients undergoing upper endoscopy in a university hospital in Brazil.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Confounding Factors, Epidemiologic; Diclof | 2006 |
Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood).
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Ligation; Male; Medici | 2007 |
Anti-ulcer activity of Adhatoda vasica Nees.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Female; Justicia; Ligation; Male | 2006 |
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Case-Control St | 2007 |
Antiulcerogenic potential of Strychnos potatorum Linn seeds on aspirin plus pyloric ligation-induced ulcers in experimental rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Female; Ligation; Male; Phytotherapy; Pla | 2007 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
Surface phospholipids in gastric injury and protection when a selective cyclooxygenase-2 inhibitor (Coxib) is used in combination with aspirin.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Gastric Muc | 2007 |
Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Centra | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Base Sequence; Cyclooxygenas | 2007 |
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Design; Drug Synergism; Female; Gastr | 2007 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Incidence of serious upper gastrointestinal bleeding in patients taking non-steroidal anti-inflammatory drugs in Japan.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cohort Studies; Du | 2008 |
Preliminary evaluation of anti-pyretic and anti-ulcerogenic activities of Sida cordifolia methanolic extract.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Fever; | 2008 |
A pioneer study on the anti-ulcer activities of copper nicotinate complex [CuCl (HNA)2] in experimental gastric ulcer induced by aspirin-pylorus [corrected] ligation model (Shay model).
Topics: Animals; Anti-Ulcer Agents; Apoptosis; Aspirin; Disease Models, Animal; DNA Fragmentation; Gastric J | 2009 |
The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Boswellia; Ethanol; Hot Temperature; Hydrochloric Acid; Indomet | 2008 |
Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric mucosa.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Availability; Cyclooxygenase 2 | 2008 |
Comparison of the gastric cytoprotective properties of atropine, ranitidine and PGE2 in rats.
Topics: Animals; Aspirin; Atropine; Dinoprostone; Ethanol; Female; Gastric Acid; Neostigmine; Parasympathomi | 1984 |
Gastric cytoprotection by prostaglandins, ranitidine, and probanthine in rats. Role of endogenous prostaglandins.
Topics: Animals; Aspirin; Epoprostenol; Furans; Gastric Juice; Gastric Mucosa; Histamine H2 Antagonists; Hyd | 1981 |
H2-receptor antagonists protect against aspirin-induced gastric lesions in the rat.
Topics: Animals; Aspirin; Cimetidine; Female; Furans; Gastric Mucosa; Histamine H2 Antagonists; Pyrilamine; | 1981 |
Aspirin-induced gastric ulcers in cats. Prevention by prostacyclin.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cats; Epoprostenol; Furans; Gastric Acid; Histamine; Histamine | 1981 |
[Effects of ranitidine, a new histamine H2-receptor antagonist, on histamine- and aspirin-induced gastric ulcers in rats and dogs (author's transl)].
Topics: Animals; Aspirin; Dogs; Dose-Response Relationship, Drug; Female; Furans; Histamine; Histamine H2 An | 1981 |
Antiulcer and mineralocorticoid activities of carbenoxolone and desoxycorticosterone in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbenoxolone; Desoxycorticosterone; Duodenum; Electrolytes; Gl | 1982 |
Pyridazinones. 1. Synthesis and antisecretory and antiulcer activities of thio amide derivatives.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Chemical Phenomena; Chemistry; Gastric Mucosa; Guinea Pigs; His | 1982 |
Effect of a new potent H2-blocker, 3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2-sulfamoyl propionamidine (YM-11170), on gastric secretion, ulcer formation and weight of male accessory sex organs in rats.
Topics: Androgen Antagonists; Animals; Aspirin; Castration; Cimetidine; Famotidine; Gastric Juice; Gastric M | 1982 |
Effects of an electrical field and its polarity on an abnormal part of the body or organ representation point associated with a diseased internal organ, and its influence on the Bi-Digital O-Ring Test (simple, non-invasive dysfunction localization method)
Topics: Acupuncture Therapy; Adult; Aspirin; Brain Ischemia; Child; Coronary Disease; Electric Stimulation T | 1982 |
Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man.
Topics: Adult; Anti-Ulcer Agents; Aspirin; Dinoprostone; DNA; Furans; Gastric Mucosa; Histamine H2 Antagonis | 1983 |
Studies of the factors that influence acetylsalicylic acid-induced gastric damage in stressed rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Female; Furans; Gastric Mucosa; Histamine H2 Antago | 1983 |
Antiulcer activity of clotiazepam in rats.
Topics: Animals; Aspirin; Atropine; Azepines; Cimetidine; Female; Gastric Juice; Gastric Mucosa; Hexosamines | 1984 |
Effects of prostaglandin E2 on transmucosal ion fluxes and aspirin-induced gastric damage in the rat.
Topics: Animals; Aspirin; Biological Transport, Active; Chlorides; Dinoprostone; Female; Gastric Mucosa; Hyd | 1983 |
Studies on pharmacological activation of human serum immunoglobulin G by chemical modification and active subfragments. III. Mechanism of anti-ulcerous action of alkylated light chain (Fr. I-L).
Topics: Animals; Anti-Ulcer Agents; Aspirin; Fasting; Fibrinolysis; Gastric Mucosa; Glycosaminoglycans; Immu | 1984 |
The activity of N-acetylglucosamine kinase in rat gastric mucosa.
Topics: Animals; Aspirin; Gastric Mucosa; In Vitro Techniques; Male; Phosphotransferases; Phosphotransferase | 1980 |
The anti-ulcerogenic activity of the unripe plantain banana (Musa species).
Topics: Aluminum Hydroxide; Animals; Anti-Ulcer Agents; Aspirin; Bucladesine; Cimetidine; Dinoprostone; DNA; | 1984 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoproston | 1984 |
The ulcerogenic potential of copper aspirinate seems to be more imaginary than real.
Topics: Animals; Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Rats; Stomach Ulcer | 1984 |
Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats.
Topics: Animals; Aspirin; Benzimidazoles; Dose-Response Relationship, Drug; Epoprostenol; Ethanol; Female; G | 1983 |
Stimulation of gastric prostaglandin synthesis by refeeding in the rat. Role in protection of gastric mucosa from damage.
Topics: Animals; Aspirin; Dinoprost; Eating; Epoprostenol; Evaluation Studies as Topic; Female; Gastric Muco | 1984 |
Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Epoprostenol; Gastric Acid; Gastric Mucosa; Intest | 1984 |
Studies on pharmacological activation of human serum IgG by chemical modification and active subfragments. II. Inhibitory effects of carboxamide-methylated L chain from human serum IgG on various ulcer models and its inhibition mechanism.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Hexosamines; Humans; Immunoglobulin G; Immunoglobulin Light Cha | 1983 |
Gastric cytoprotection by acetazolamide: role of endogenous prostaglandins.
Topics: Acetazolamide; Animals; Aspirin; Carbonic Anhydrases; Dinoprostone; Drug Evaluation; Ethanol; Female | 1983 |
Correlations between changes in indicators of gastric mucosal barrier integrity at time of exposure to "barrier breakers" and extent of hemorrhagic erosions one hour later.
Topics: Animals; Aspirin; Ethanol; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Mannitol; Prognosis; | 1984 |
Canine gastric ulcer produced by hemorrhagic shock and aspirin.
Topics: Acids; Animals; Aspirin; Dogs; Female; Gastric Mucosa; Male; Shock, Hemorrhagic; Stomach; Stomach Ul | 1984 |
Effect of bromocriptine, a dopamine receptor agonist, on the experimentally induced gastric ulcers in albino rats.
Topics: Animals; Aspirin; Bromocriptine; Female; Gastric Mucosa; Male; Phenylbutazone; Rats; Rats, Inbred St | 1984 |
Evidence for thimerosal induced cytoprotection on rat stomach.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Ethanol; Ethylmercury Compounds; Gastric Mucosa; | 1984 |
Antisecretory and protective properties of prostaglandin analogues in man.
Topics: 16,16-Dimethylprostaglandin E2; Adult; Aspirin; Bile Acids and Salts; Dose-Response Relationship, Dr | 1984 |
Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats.
Topics: Animals; Aspirin; Chromones; Cimetidine; Gastric Juice; Histamine; Humans; Male; Mast Cells; Pylorus | 1984 |
Effects of exogenous administration of female sex hormones on gastric secretion and ulcer formation in the rat.
Topics: Animals; Aspirin; Estrogens; Gastric Juice; Gonadal Steroid Hormones; Humans; Indomethacin; Male; Pr | 1984 |
[Animal experimental studies on the question of the interaction of paracetamol and acetylsalicylic acid].
Topics: Acetaminophen; Animals; Aspirin; Body Temperature; Exudates and Transudates; Female; Glutathione; Li | 1984 |
Antiulcer effects of trimipramine using various laboratory models.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dibenzazepines; Disease Models, Animal; Humans; Mal | 1984 |
Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cysteamine; Drug Evaluation, Preclinical; Duoden | 1984 |
Aspirin and the gastric mucosa.
Topics: Aspirin; Gastric Mucosa; Humans; Stomach Ulcer | 1984 |
Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC).
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Carbazoles; Duodenal Ulcer; Gastric Mucosa; Humans; Indome | 1984 |
Functional cytoprotection by certain antacids.
Topics: Animals; Antacids; Aspirin; Dinoprostone; Ethanol; Gastric Acidity Determination; Gastric Mucosa; In | 1984 |
Distinction between antiulcer effect and cytoprotection.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Female; Ga | 1984 |
Thrombotic etiology of stress ulcers. 1. The effect of anticoagulant and antiplatelet aggregators in the development of stress ulcers in rats.
Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Gastric Acidity Determination; Gastric Mucosa; Hepar | 1983 |
The preventive effect of low-dose aspirin in the development of stress ulceration in rats.
Topics: Animals; Aspirin; Gastric Acid; Gastric Mucosa; Male; Peptic Ulcer Hemorrhage; Platelet Aggregation; | 1983 |
Omeprazole provides protection against experimentally induced gastric mucosal lesions.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Ethanol; Female; Injections, Intravenous; Omepr | 1983 |
The effect of 3-methoxy-5,7,3',4'-tetrahydroxyflavan on the restraint induced gastric ulceration augmented by aspirin, a gastric mucosal barrier breaker.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Catechin; Cimetidine; Flavonoids; Gastric Mucosa; Male; Rats; R | 1983 |
Combined ulcerogenic effect of ethanol and acetylsalicylic acid on the gastric mucosa of the rat.
Topics: Animals; Aspirin; Drug Synergism; Ethanol; Gastric Mucosa; Histamine; Male; Rats; Rats, Inbred Strai | 1983 |
Inhibitory effects of unsaturated fatty acids of trans-2-C10:1 to trans-2-C16:1 several C18:n and C20:n on gastric secretion and experimental ulceration in rats.
Topics: Animals; Aspirin; Capillary Permeability; Fatty Acids, Unsaturated; Gastric Emptying; Gastric Juice; | 1983 |
Comparison of aspirin and copper aspirinate with respect to gastric mucosal damage in the rat.
Topics: Animals; Aspirin; Buffers; Copper; Gastric Mucosa; Male; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
Effect of prostaglandin synthesis inhibitors on neurotensin and sodium salicylate-induced gastric cytoprotection in rats.
Topics: Animals; Aspirin; Cold Temperature; Ethanol; Humans; Indomethacin; Male; Neurotensin; Prostaglandin | 1983 |
Anti-ulcer activity and other pharmacological properties of lozilurea.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Dogs; Duodenal Ulcer; Female; Gastric Mucosa; Guinea Pigs; Hexo | 1983 |
A study of the effects of tamrabhasma, an indigenous preparation of copper on experimental gastric ulcers & secretion.
Topics: Animals; Ascorbic Acid; Aspirin; Copper; Drug Combinations; Female; Ferrous Compounds; Gastric Juice | 1983 |
Effects of an antiulcer drug, sucralfate (a basic aluminum salt of sulfated disaccharide), on experimental gastric lesions and gastric secretion in rats.
Topics: Acetates; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Gastric Mucosa; Histamine; Indomethacin; Ra | 1983 |
Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats.
Topics: Animals; Aspirin; Benzimidazoles; Chemical Phenomena; Chemistry; Duodenal Ulcer; Epirizole; Gastric | 1984 |
Lysophosphatidylcholine-induced gastric injury and ulceration in the guinea pig.
Topics: Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Duodenogastric Reflux; Gastric | 1984 |
Effect of oral 16,16-dimethyl prostaglandin E2 on gastric mucosal salicylate concentration in the rat.
Topics: Administration, Oral; Animals; Aspirin; Chromatography, High Pressure Liquid; Female; Gastric Mucosa | 1984 |
Changes of gastric mucus glycoproteins with aspirin administration in rats.
Topics: Animals; Aspirin; Gastric Mucosa; Glycoproteins; Male; Rats; Rats, Inbred Strains; Stomach Ulcer; Ti | 1984 |
Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats.
Topics: Animals; Aspirin; Diffusion; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Necrosis; Pepsin A; P | 1980 |
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Indomethacin; Intestinal Diseases; Male; | 1981 |
Aspirin and the stomach.
Topics: Aspirin; Drug Administration Schedule; Gastrointestinal Hemorrhage; Humans; Stomach Ulcer | 1981 |
Aspirin and the stomach.
Topics: Aspirin; Humans; Peptic Ulcer Hemorrhage; Stomach Ulcer | 1981 |
The cytoprotective effects of (+/-)-15-deoxy-16-alpha, beta-hydroxy-16-methyl PGE1 methyl ester (sc-29333) versus aspirin-shock gastric ulcerogenesis in the dog.
Topics: Animals; Aspirin; Dogs; Gastric Mucosa; Misoprostol; Prostaglandins E, Synthetic; Shock, Hemorrhagic | 1981 |
Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Carrageenan; Clonidine; Drug Therapy, | 1983 |
Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent.
Topics: Aluminum; Animals; Aspirin; Barium Sulfate; Drug Evaluation; Endoscopy; Gastric Mucosa; Humans; Isot | 1983 |
Gastric antisecretory and cytoprotective activities of SCH 28080.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa | 1983 |
[Effects of SM powder, a combined herbal preparation for stomach diseases, on gastric secretion and acute gastro-duodenal lesions in rats].
Topics: Animals; Aspirin; Depression, Chemical; Duodenal Ulcer; Ethanol; Gastric Juice; Immersion; Indometha | 1983 |
Exacerbation of acetic acid ulcer induced by non-steroidal anti-inflammatory drugs in rats.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Aspirin; Gastric Emptying; Gastric Juice; | 1983 |
Peptic ulcer disease in children. Aspirin induced.
Topics: Aspirin; Child, Preschool; Humans; Infant; Male; Peptic Ulcer Hemorrhage; Stomach Ulcer | 1981 |
Role of prostaglandin E2 on gastric ulcers induced by non-steroidal anti-inflammatory compounds (NOSAC).
Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Prostaglandins E; Rats; Rats, In | 1981 |
[The role of endogenous prostaglandin in drug-induced gastrointestinal lesions--comparison of aspirin and indomethacin (author's transl)].
Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Diseases; Intestinal Mucosa | 1981 |
Relationship between lesion formation and permeability of rat gastric mucosa to H+ and other cations.
Topics: Animals; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Hydrogen; | 1982 |
The prevalence of duodenal lesions in patients with rheumatic diseases on chronic aspirin therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Buffers; Duodenal Diseases; Duodenal Ulcer; Endoscopy; | 1980 |
Are all aspirins really alike? A comparison of gastric ulcerogenicity with bio-efficacy in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Avai | 1980 |
Enteric-coated aspirin and gastric erosion.
Topics: Aspirin; Humans; Rheumatic Diseases; Stomach Ulcer; Tablets, Enteric-Coated | 1980 |
Gastric ulcerogenic and biological activities of N-3'a-propyphenazonyl-2-acetoxybenzamide.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; | 1980 |
Anti-inflammatory/anti-pyretic salicylic acid esters with low gastric ulcerogenic activity.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Evaluation | 1980 |
Controlled comparison of gastric lesions and gastrointestinal blood loss with fluproquazone and acetylsalicylic acid (ASA) in healthy subjects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation Factors; Blood Platelets; Female | 1981 |
Prevention of ethanol and aspirin-induced gastric mucosal lesions by paracetamol and salicylate in rats: role of endogenous prostaglandins.
Topics: Acetaminophen; Animals; Aspirin; Epoprostenol; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; | 1982 |
Role of gastric mucosal folds in formation of focal ulcers in the rat.
Topics: Action Potentials; Animals; Aspirin; Disease Models, Animal; Gastric Mucosa; Ischemia; Permeability; | 1982 |
The influence of paracetamol on the erosive activity of indomethacin in the rat stomach.
Topics: Acetaminophen; Administration, Oral; Animals; Aspirin; Indomethacin; Injections, Subcutaneous; Male; | 1982 |
Effects of the antiulcer drug geranylgeranylacetone on aspirin-induced gastric ulcers in rats.
Topics: Animals; Aspirin; Diterpenes; Gastric Mucosa; Gefarnate; Hexosamines; Male; Rats; Rats, Inbred Strai | 1982 |
Testing for drugs inhibiting the formation of gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cold Temperature; Copper; Indomethacin; Mucus; Orga | 1982 |
Effect of geranylgeranylacetone (GGA) on gastric lesions induced by topical aspirin plus HCl.
Topics: Administration, Topical; Animals; Aspirin; Diterpenes; Hydrochloric Acid; Male; Rats; Rats, Inbred S | 1982 |
Gastroprotective and anti-inflammatory properties of green lipped mussel (Perna canaliculus) preparation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bivalvia; Female; Freeze Drying; Indomethacin; Male; Rat | 1980 |
Effects of CL-1700 and its constituents on acute or chronic gastric lesions and gastric secretion in rats.
Topics: Aluminum Hydroxide; Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dipeptides; Gastric Juice; Hista | 1982 |
Gastric anti-ulcer activity of (+)-cyanidanol-3, a histidine decarboxylase inhibitor.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzopyrans; Carboxy-Lyases; Catechin; Female; Gastric Acidity | 1981 |
Bio-distribution in rats of some salicylates with low gastric ulcerogenicity.
Topics: Animals; Aspirin; Male; Rats; Salicylates; Stomach Ulcer; Tissue Distribution | 1980 |
Prostaglandin E2 in gastric mucosa and its role in the prevention of ulcers induced by acetyl salicylic acid in cats.
Topics: Animals; Aspirin; Cats; Gastric Juice; Gastric Mucosa; Histamine; Hydrochloric Acid; Prostaglandins | 1981 |
Regeneration of gastric mucosa after aspirin induced injury in Clarias batrachus (Linn.).
Topics: Animals; Aspirin; Fishes; Gastric Mucosa; Regeneration; Stomach Ulcer | 1981 |
Experimental evidence for cytoprotective effect of atropine on the rat gastric mucosa.
Topics: Animals; Aspirin; Atropine; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Male; Rats; St | 1980 |
Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion.
Topics: Adolescent; Adult; Aged; Antacids; Arthritis, Rheumatoid; Aspirin; Cimetidine; Duodenal Ulcer; Femal | 1981 |
Decreased gastrointestinal ulcerogenicity of chlordimeform, a basic anti-inflammatory agent.
Topics: Amidines; Animals; Anti-Inflammatory Agents; Aspirin; Chlorphenamidine; Intestinal Diseases; Male; R | 1981 |
Indomethacin produces gastric antral ulcers in the refed rat.
Topics: Adrenalectomy; Animals; Aspirin; Fasting; Indomethacin; Intestines; Male; Phenylbutazone; Prostaglan | 1981 |
[Changes in the mucous barrier of the stomach due to some drugs (author's transl)].
Topics: Aspirin; Gastric Acidity Determination; Gastric Mucosa; Humans; Male; Middle Aged; Peptic Ulcer Hemo | 1981 |
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin; | 1980 |
Gastric cytoprotection by sodium salicylate.
Topics: Animals; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Salicylates; Salicylic Acid; St | 1981 |
Study of antiulcer activity of aqueous extract of leaves of Pyrenacantha staudtii (family Icacinaceae) using various models of experimental gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Female; Indomethacin; Male; Nigeria; Pl | 1981 |
Effects of N-acetyl-L-carnosine aluminum (CL-1700) on various acute gastric lesions and gastric secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dipeptides; Gastric Mucosa; Indomethacin; Male; Phen | 1981 |
[The meaning of specialist and adequate documentation for retrospective analysis of sicknesses (author's transl)].
Topics: Aspirin; Documentation; Duodenal Ulcer; Humans; Postoperative Complications; Prospective Studies; Ra | 1981 |
Reduction of aspirin-induced ulcers by a new imidazoline anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Clonidine; Drug Interactions; Gastric Acid; Male; Mice; | 1981 |
Gastroscopic evaluation of anti-inflammatory agents.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Administration Schedule; | 1980 |
Aspirin-induced gastric bleeding stops despite rising plasma salicylate.
Topics: Aspirin; Female; Gastric Mucosa; Humans; Kinetics; Male; Salicylates; Stomach Ulcer | 1980 |
Benign gastric ulceration in pernicious anemia.
Topics: Achlorhydria; Aged; Anemia, Pernicious; Aspirin; Female; Humans; Stomach Ulcer | 1980 |
The role of gastric mucosal hexosamine in aspirin-induced ulcers.
Topics: Animals; Aspirin; Gastric Mucosa; Glutamine; Hexosamines; Male; Proglumide; Rats; Stomach Ulcer; Wou | 1980 |
Biochemical gastroprotection from acute ulceration induced by aspirin and related drugs.
Topics: Amino Acids; Animals; Aspirin; Buffers; Carrageenan; Edema; Female; Glucose; Male; Rats; Stomach Ulc | 1980 |
Effects of bergenin on experimental ulcers--prevention of stress induced ulcers in rats.
Topics: Animals; Aspirin; Benzopyrans; Gastric Juice; Gastrointestinal Motility; Guinea Pigs; Histamine; Jap | 1980 |
Comparison of intravenous and intragastric aspirin in production of antral gastric ulcers in cats.
Topics: Animals; Aspirin; Cats; Female; Histamine; Infusions, Parenteral; Male; Prostaglandins; Pyloric Antr | 1980 |
Pharmacological study of aspirin induced acute gastric ulceration in rabbit.
Topics: Animals; Aspirin; Atropine; Cyproheptadine; Guinea Pigs; Rabbits; Rats; Species Specificity; Stomach | 1980 |
Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats.
Topics: Animals; Aspirin; Chromatography, Gel; Gastric Mucosa; Glycoproteins; Male; Rats; Stomach Ulcer; Tim | 1980 |
[Cytoprotection. A new fashion or real progress?].
Topics: Animals; Aspirin; Gastric Mucosa; Gastritis; Humans; Indomethacin; Prostaglandins E, Synthetic; Rats | 1980 |
Effect of proglumide on glycoprotein synthesis in aspirin-induced gastric erosions in rats.
Topics: Acetylglucosamine; Animals; Aspirin; Fasting; Gastric Mucosa; Glutamine; Glycoproteins; Male; Proglu | 1980 |
Role of prostaglandins in the formation of aspirin-induced gastric ulcers.
Topics: Animals; Aspirin; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; Male; Prostaglandin Antagonists; | 1981 |
Analgesic ingestion and chronic peptic ulcer.
Topics: Acetaminophen; Analgesics; Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer; R | 1981 |
Focal microcirculatory changes during the production of aspirin-induced gastric mucosal erosions.
Topics: Animals; Aspirin; Dogs; Female; Gastric Mucosa; Ischemia; Male; Microcirculation; Microspheres; Stom | 1981 |
Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Drug Evaluation, | 1995 |
Antiulcer and gastric secretory activity of N-octanoyl gamma-aminobutyric acid.
Topics: Animals; Antacids; Anti-Ulcer Agents; Aspirin; Cold Temperature; Ethanol; gamma-Aminobutyric Acid; G | 1995 |
Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspirin; Cholecystokinin; Dose-Response Relationship, | 1995 |
Studies on antiulcer agents. II. Antiulcer properties of N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides inhibiting release of histamine from passively sensitized rat peritoneal mast cells.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cromolyn Sodium; Ethanol; Histamine H1 Antagonists; | 1995 |
Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis).
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; India; Indomethacin; Plant Extracts; Pros | 1995 |
Aspirin, salicylate and gastrointestinal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Detergents; Gastric Mucosa; Gas | 1995 |
Which patients taking non-aspirin non-steroidal anti-inflammatory drugs bleed? A case-control study.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Alcoholism; Anti-Inflammatory Agents, Non-Steroida | 1995 |
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci | 1995 |
3-substituted piperazinomethyl benzoxazolinones. Analgesic and anti-inflammatory compounds inhibiting prostaglandin E2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoxazoles; Carrageenan; Edema; Female; | 1995 |
Effect of dissolution profile and (-)-alpha-bisabolol on the gastrotoxicity of acetylsalicylic acid.
Topics: Animals; Aspirin; Chemistry, Pharmaceutical; Gastric Mucosa; Male; Monocyclic Sesquiterpenes; Necros | 1995 |
Production of acute gastric erosions in the cat by individual human pepsins.
Topics: Acute Disease; Animals; Aspirin; Cats; Dose-Response Relationship, Drug; Drug Synergism; Female; Gas | 1995 |
Topical nicotine protects rat gastric mucosa against ASA-induced damage. A role for mucosal fluid secretion in cytoprotection.
Topics: Administration, Topical; Animals; Aspirin; Gastric Juice; Gastric Mucosa; Hydrogen-Ion Concentration | 1995 |
Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats.
Topics: Abietanes; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dinoprostone; Diterpenes; Drug Therapy, | 1995 |
[Can early recurrent hemorrhage in gastroduodenal ulcer be predicted?].
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; En | 1994 |
[Pharmacological studies on the effects of huanglian decoction on experimental gastric lesions in rats and antiemetic in pigeons].
Topics: Animals; Anti-Ulcer Agents; Antiemetics; Aspirin; Columbidae; Drug Combinations; Drugs, Chinese Herb | 1994 |
Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Aspirin; Bleeding Time; Collagen; Fibrinolytic Agents; | 1994 |
Effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion in pylorus-ligated rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Gastric Acid; Gastric Mucos | 1995 |
Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Blood Flow Velocity; Dogs; Gastric Acid; Gastric Mucosa; Guanid | 1994 |
Synthesis and anti-inflammatory properties of 1,2-dialkoxy-4-(3-dimethylaminopropionyl)benzenes and their 5-halogeno derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Foot Inju | 1994 |
A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats.
Topics: Animals; Aspirin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Ethanol; Gastric Mucosa; Hy | 1994 |
[Effect of KW-5805 on gastric mucus changes induced by water immersion-restraint stress and aspirin in rats].
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzoxepins; Gastric Mucosa; Glycoproteins; Immersion; Mucus; R | 1994 |
Anti-ulcer effect of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid on experimental gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Hydrochloric Acid; Male; p-Metho | 1994 |
The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats.
Topics: Animals; Aspirin; Carbenoxolone; Dosage Forms; Glycyrrhetinic Acid; Glycyrrhiza; Male; Plant Extract | 1994 |
The role of endogenous nitric oxide in the gastroprotective action of morphine.
Topics: Animals; Anti-Ulcer Agents; Arginine; Aspirin; Cysteamine; Dinoprostone; Ethanol; Ethylmaleimide; Fe | 1994 |
Gastro-duodenal injury associated with intake of 100-325mg aspirin daily.
Topics: Aged; Aged, 80 and over; Aspirin; Drug Administration Schedule; Female; Humans; Stomach Ulcer | 1994 |
Asynchrony in circadian rhythms of gastric function in the rat. A model for gastric mucosal injury.
Topics: Animals; Aspirin; Bicarbonates; Cimetidine; Circadian Rhythm; Disease Models, Animal; Epoprostenol; | 1994 |
Protective effects of arginine-vasopressin on aspirin-induced gastric mucosal damage in anaesthetized dogs.
Topics: Animals; Arginine Vasopressin; Aspirin; Blood Pressure; Dinoprostone; Dogs; Female; Gastric Mucosa; | 1994 |
Cytoprotective effect of NC-1300-O-3 against gastric lesions induced by necrotizing agents in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Capill | 1994 |
Effects of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl] urea with potent gastric mucosal protective activity on acute gastric lesions and duodenal ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cyanides; Duodenal Ulcer; Epirizole; Ethanol; Gastric Mucosa; H | 1993 |
Effects of misoprostol on delayed ulcer healing induced by aspirin.
Topics: Acetates; Acetic Acid; Animals; Aspirin; Gastric Mucosa; Male; Misoprostol; Rats; Rats, Inbred Strai | 1994 |
Gastro-duodenal injury associated with intake of 100-325 mg aspirin daily.
Topics: Acute Disease; Aged; Aged, 80 and over; Aspirin; Drug Administration Schedule; Duodenal Ulcer; Femal | 1993 |
Gastrocolic fistula-secondary to aspirin abuse.
Topics: Aspirin; Colonic Diseases; Female; Gastric Fistula; Humans; Intestinal Fistula; Middle Aged; Stomach | 1993 |
Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage.
Topics: Administration, Oral; Animals; Arthritis; Aspirin; Female; Gastric Mucosa; Indoles; Indomethacin; In | 1993 |
The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor.
Topics: Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Guinea Pigs; Humans; In Vitro Techniqu | 1993 |
Circadian rhythm in aspirin (ASA)-induced injury to the stomach of the fasted rat.
Topics: Animals; Aspirin; Circadian Rhythm; Gastric Mucosa; Male; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1993 |
Fibroblast growth factor in gastroprotection and ulcer healing: interaction with sucralfate.
Topics: Acetates; Acetic Acid; Acute Disease; Animals; Aspirin; Disease Models, Animal; Dose-Response Relati | 1993 |
Gastrocolic fistulas: the increasing role of aspirin.
Topics: Adult; Aged; Aspirin; Colonic Diseases; Female; Gastric Fistula; Humans; Intestinal Fistula; Male; M | 1993 |
Enhancement of anti-inflammatory activity of aspirin by verapamil.
Topics: Adrenal Glands; Animals; Aspirin; Carrageenan; Drug Synergism; Female; Foreign Bodies; Inflammation; | 1993 |
Noninvasive detection of nonsteroidal anti-inflammatory drug-induced gastropathy in dogs.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dog Diseases; Dogs; | 1995 |
NSAID-induced delay in gastric ulcer healing is not associated with decreased epithelial cell proliferation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Epithelial Cells; Epitheli | 1995 |
[The prophylactic taking of low doses of acetylsalicylic acid and the risk of ulcer hemorrhage].
Topics: Aspirin; Dose-Response Relationship, Drug; Duodenal Ulcer; Humans; Middle Aged; Peptic Ulcer Hemorrh | 1995 |
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Epirizole; | 1995 |
Gastric adaptation to aspirin and stress enhances gastric mucosal resistance against the damage by strong irritants.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; | 1996 |
Some pharmacological properties of Synclisia scabrida II.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cholinergic Antagonists; Female; Histamine H1 Antagonists; Ileu | 1996 |
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat.
Topics: Animals; Aspirin; Benzofurans; Ethanol; Female; Gastritis; Indomethacin; Iodoacetamide; Leukotriene | 1996 |
Synthesis and anti-inflammatory properties of 8-(3-dimethylaminopropionyl)-1,6-benzodioxocane.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bri | 1995 |
Transdermal aspirin and gastric ulcer healing after coronary artery stent placement.
Topics: Administration, Cutaneous; Arteries; Aspirin; Coronary Vessels; Humans; Male; Middle Aged; Postopera | 1996 |
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atrophy; Bacterial | 1997 |
Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs.
Topics: Animals; Aspirin; Benzopyrans; Cromakalim; Duodenal Ulcer; Female; Guinea Pigs; Histamine; Male; Pot | 1997 |
Recovery of mucin content in surface layer of rat gastric mucosa after HCl-aspirin-induced mucosal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Hydrochloric Acid; Hydrog | 1997 |
Gastric mucosal injury by nonsteroidal anti-inflammatory drugs is reduced by (R)-alpha-methylhistamine and its pro-drugs in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Acid; Gastric Mucosa; Histamine A | 1997 |
[NSAID and ulcer complications. An analysis of risk factors].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Databases, Factual; Female; Humans; M | 1997 |
Salicylate levels in rat stomach tissues after administration of aspalatone and acetylsalicylic acid in relation to their ulcerogenicity.
Topics: Animals; Aspirin; Gastric Mucosa; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; | 1997 |
Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
The role of melatonin and L-tryptophan in prevention of acute gastric lesions induced by stress, ethanol, ischemia, and aspirin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; DNA; Dose-Response Relatio | 1997 |
Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Gastric Mucosa; Granulatio | 1997 |
Studies on the possible mechanism of the gastric mucosal protection by Calotropis procera--involvement of 5-lipoxygenase pathway.
Topics: Animals; Anti-Ulcer Agents; Arachidonate 5-Lipoxygenase; Aspirin; Ethanol; Female; Gastric Mucosa; G | 1998 |
Phosphatidylcholine-associated aspirin accelerates healing of gastric ulcers in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Combinations; Male; Pho | 1998 |
Nonsteroidal anti-inflammatory drugs and gastrocolic fistula.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Colonic Diseases; Female; G | 1998 |
Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Acid; Gastric Acidity Determinati | 1998 |
Warning patients about cocaine and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cocaine-Related Disorders; Colonic Diseases; Gastr | 1998 |
Warning patients about cocaine and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cocaine-Related Disorders; Colonic Diseases; Gastr | 1998 |
Warning patients about cocaine and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cocaine-Related Disorders; Colonic Diseases; Gastr | 1998 |
Warning patients about cocaine and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cocaine-Related Disorders; Colonic Diseases; Gastr | 1998 |
Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 1998 |
Focused antithrombotic therapy: novel anti-platelet salicylates with reduced ulcerogenic potential and higher first-pass detoxification than aspirin in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Blood Platelets; Diflunisal; Do | 1998 |
Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Gastric Acid; Gastric | 1998 |
Effect of roxatidine bismuth citrate (MX1) against acetylsalicylic acid- and indomethacin-induced gastric mucosal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug Combinations; Dru | 1998 |
Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Cyclooxygenase 2; Dinoprosto | 1998 |
Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Gastric Acid; Gastric Mucos | 1999 |
[Thrombosis prophylaxis in stomach ulcer].
Topics: Aspirin; Contraindications; Fibrinolytic Agents; Humans; Stomach Ulcer; Thrombosis | 1999 |
Genotypes of Helicobacter pylori obtained from gastric ulcer patients taking or not taking NSAIDs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Bacterial; Aspirin; Bacterial Outer | 1999 |
Effect of ulceration on rat gastric tissue polyamine contents in response to different procedures; inhibition of these effects by cimetidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cimetidine; Gastric Mu | 1999 |
NSAIDs and alcohol: never the twain shall mix?
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase | 1999 |
The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption.
Topics: Acute Disease; Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Contro | 1999 |
Low-dose aspirin may or may not damage the gastric mucosa.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Gastric Mucosa; | 1999 |
Enhanced expression of leptin following acute gastric injury in rat.
Topics: Animals; Aspirin; Blotting, Western; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Lept | 1999 |
Protective effect of the nitric oxide donor molsidomine on indomethacin and aspirin-induced gastric injury in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Gas | 2000 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 1999 |
Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica.
Topics: Acetaldehyde; Animals; Anti-Ulcer Agents; Aspirin; Cycadopsida; Disease Models, Animal; Gastric Juic | 2000 |
Effect of mild irritant on gastric mucosal offensive and defensive factors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cold Temperature; Electrophoresis, Polyac | 2000 |
Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Aspirin; Dothiep | 2000 |
Effects of Teucrium divaricatum Heldr. ssp. divaricatum decoction on experimental ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Gastric Mucosa; Male; | 2000 |
Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa; | 2000 |
Images in clinical medicine. An aspirin tablet and a gastric ulcer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Etodolac; Female; Foreign Bodies; Gastroscop | 2000 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 2000 |
Experimental evaluation of Bocopa monniera on rat gastric ulceration and secretion.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Central Nervous System Depressants; Cold Temperature; DNA; Duod | 2000 |
Role of mucus reduction and luminal acid elevation in increased susceptibility of stomach to nonsteroidal antiinflammatory drug-induced injury in arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Dinoprostone; Do | 2000 |
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood | 2001 |
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cycloo | 2001 |
[Upper gastrointestinal bleeding in patients treated by low-dose aspirin].
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Duodenal Ulcer; Female; France; Gastrointestinal Hemorrhage | 2001 |
Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Blood Flow Veloc | 2001 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, | 2001 |
Prophylactic and curative effects of Bacopa monniera in gastric ulcer models.
Topics: Acetic Acid; Animals; Antioxidants; Aspirin; Catalase; Cell Division; Cold Temperature; Disease Mode | 2001 |
Effect of butanol fraction of Panax ginseng head on gastric lesion and ulcer.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Butanols; Gast | 2002 |
Effects of Opuntia ficus-indica var. Saboten stem on gastric damages in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ethanol; Ficus; Gastric Juice; Gastric Mu | 2002 |
Gastroprotective activity of solidagenone on experimentally-induced gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Drug; Furans; Male; Naphthalenes; O | 2002 |
Aspirin injury and H pylori.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gerbillinae; Helicobacter Infections; Hel | 2002 |
Helicobacter pylori infection potentiates aspirin induced gastric mucosal injury in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotactic Factors; Gastric Mucosa; Gerb | 2002 |
Role of elastase and active oxygen species in gastric mucosal injury induced by aspirin administration in Helicobacter pylori-infected Mongolian gerbils.
Topics: Animals; Aspirin; Catalase; Free Radical Scavengers; Gastric Mucosa; Gerbillinae; Glycine; Helicobac | 2002 |
[Induction of syndecan-1 expression in parietal cells during gastric mucosal injury by NSAIDs].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Membrane Glycoproteins; Mice; | 2002 |
Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 2002 |
Gastroprotective activity of oleanolic acid derivatives on experimentally induced gastric lesions in rats and mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Aspirin; Dose-Response Relation | 2002 |
[Low-dose of aspirin, gastroprotection and Helicobacter pylori erradication].
Topics: Aged; Aspirin; Helicobacter Infections; Helicobacter pylori; Humans; Platelet Aggregation Inhibitors | 2002 |
Gastric mucus effusion elicited by oral copper compounds: potential anti-ulcer activity.
Topics: Administration, Oral; Animals; Aspirin; Copper; Edema; Female; Foot; Gastric Mucosa; Hindlimb; Hydro | 1976 |
Mechanism of prevention of aspirin-induced gastric lesions by bile duct legation in the rat.
Topics: Animals; Aspirin; Colon; Common Bile Duct; Gastric Juice; Gastric Mucosa; Hydrogen-Ion Concentration | 1976 |
Gastric mucosal lesions produced by intravenous infusion of aspirin in cats.
Topics: Animals; Aspirin; Body Weight; Cats; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Hydro | 1976 |
Effects of L-glutamine of acetylsalicylic acid or taurocholic acid-induced gastric lesions and secretory changes in pylorus-ligated rats under normal or stress conditions.
Topics: Animals; Aspirin; Drug Interactions; Gastric Juice; Gastric Mucosa; Glutamine; Hydrogen-Ion Concentr | 1976 |
Aspirin esterase of gastric mucosal origin.
Topics: Age Factors; Alcoholic Beverages; Aspirin; Drug Stability; Duodenal Ulcer; Esterases; Ethanol; Femal | 1977 |
Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers.
Topics: Administration, Oral; Animals; Aspirin; Carbachol; Depression, Chemical; Disease Models, Animal; Duo | 1977 |
Gastric mucosal ulceration induced in pigs by tabelts but not suspensions or solutions of aspirin.
Topics: Animals; Aspirin; Female; Solutions; Stomach Ulcer; Suspensions; Swine; Tablets | 1978 |
Gastric erosions induced by analgesic drug mixtures in the rat.
Topics: Acetaminophen; Animals; Aspirin; Caffeine; Drug Combinations; Female; Lethal Dose 50; Phenacetin; Ra | 1978 |
Inhibitors of gastric lesions in the rat.
Topics: Animals; Aspirin; Disease Models, Animal; Female; Glutamine; Histamine Antagonists; Indomethacin; Li | 1978 |
Gastric ulceration and the concentration of salicylate in plasma in rats after administration of 14C-labelled aspirin and its synthetic triglyceride, 1,3-dipalmitoyl-2(2'-acetoxy-[14C]carboxylbenzoyl) glycerol.
Topics: Animals; Aspirin; Chyle; Male; Rats; Salicylates; Stomach Ulcer; Time Factors; Triglycerides | 1978 |
Effect of prostaglandin E2 on aspirin-induced gastric mucosal injury.
Topics: Animals; Aspirin; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Hu | 1979 |
[Experimental comparative study of acute toxicity and gastric tolerance of eterylate, benorylate and acetylsalicylic acid (author's transl)].
Topics: Acetanilides; Acute Disease; Animals; Anti-Inflammatory Agents; Aspirin; Drug Evaluation, Preclinica | 1978 |
Protection by histamine receptor antagonists and prostaglandin against gastric mucosal barrier disruption in the rat.
Topics: Administration, Topical; Animals; Aspirin; Cimetidine; Drug Combinations; Gastric Juice; Gastric Muc | 1979 |
The activation of pepsinogen inside the gastric mucosa caused by the hydrogen ion back diffusion during the course of aspirin ulceration.
Topics: Animals; Aspirin; Diffusion; Enzyme Activation; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Pe | 1979 |
Histamine H2 receptor: involvement in gastric ulceration.
Topics: Animals; Aspirin; Corticosterone; Female; Histamine; Histamine H1 Antagonists; Histamine Release; Me | 1976 |
Duodenogastric reflux of bile and aspirin-induced gastric damage in man.
Topics: Aspirin; Bile; Humans; Peptic Ulcer Hemorrhage; Stomach Ulcer | 1977 |
The effects of nutrition on aspirin-induced mucosal ulceration in primates.
Topics: Animals; Aspirin; Body Weight; Diet; Gastric Acidity Determination; Haplorhini; Macaca; Male; Nitrog | 1979 |
Studies on the mechanism of action of cetraxate [4'-(2-carboxyethyl)phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride], a new anti-ulcer agent.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Connective Tissue; Cyclohexanecarboxylic Acids; Femal | 1979 |
Ulcer formation and histochemical changes in rat-stomach mucosa induced by acetylsalicylic acid.
Topics: Adenosine Triphosphatases; Animals; Aspirin; Dihydrolipoamide Dehydrogenase; Duodenum; Electron Tran | 1976 |
Effects of blood glucose levels on aspirin-induced gastric mucosal damage.
Topics: Adrenal Cortex Hormones; Animals; Aspirin; Blood Glucose; Bucladesine; Cyclic AMP; Cyclic GMP; Diabe | 1977 |
[Massive pneumoperitoneum as a sequela to rupture of a gastric ulcer and ventilatory resuscitation under pressure].
Topics: Aspirin; Drowning; Female; Humans; Middle Aged; Oxygen Inhalation Therapy; Peptic Ulcer Perforation; | 1978 |
Stress ulceration and the gastric mucosal barrier.
Topics: Animals; Aspirin; Bile Acids and Salts; Cats; Disease Models, Animal; Ethanol; Gastric Acidity Deter | 1975 |
Gastro-colic fistula complicating benign gastric ulcer in analgesic abusers.
Topics: Adult; Aspirin; Colonic Diseases; Female; Gastric Fistula; Humans; Intestinal Fistula; Stomach Ulcer | 1979 |
Relationship between gastric ulceration and mucosal prostaglandin concentrations following chronic oral administration of aspirin preparations to pigs.
Topics: Administration, Oral; Animals; Aspirin; Intestinal Mucosa; Prostaglandins; Stomach Ulcer; Swine | 1979 |
Acute upper-gastrointestinal hemorrhage. New observations on an old problem.
Topics: Alcohol Drinking; Aspirin; Duodenal Ulcer; Esophageal and Gastric Varices; Esophagoscopy; Gastritis; | 1978 |
Gastrointestinal and other side-effects from the use of aspirin and related drugs; biochemical studies on the mechanisms of gastrotoxicity.
Topics: Animals; Aspirin; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Guinea Pigs; Humans; Pregnanc | 1977 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
The effects of aspirin and other non-steroid anti-inflammatory/analgesic drugs on gastro-intestinal mucus glycoprotein biosynthesis in vivo: relationship to ulcerogenic actions.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Glycoproteins; | 1978 |
Aspirin and the stomach.
Topics: Aspirin; Gastrointestinal Hemorrhage; Humans; Stomach Ulcer | 1978 |
Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy.
Topics: Adult; Aged; Aspirin; Buffers; Female; Gastroscopy; Humans; Male; Middle Aged; Rheumatic Diseases; S | 1979 |
Alternatives to aspirin, derived from biological sources.
Topics: Animals; Aspirin; Enterobacter; Escherichia coli; Female; Inflammation; Male; Mice; Platelet Aggrega | 1977 |
Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates.
Topics: Animals; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Female; Gastric Juice; Gastric Mucos | 1978 |
Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine.
Topics: Animals; Aspirin; Cimetidine; Depression, Chemical; Gastric Juice; Guanidines; Hydrochloric Acid; In | 1979 |
Effects of topical 16,16-dimethyl prostaglandin E2 on aspirin ulcerogenesis.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Dogs; Gastric Acid; Gastric Mucosa; Prostaglandins | 1978 |
Aspirin and ulcers.
Topics: Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Male; Stomach Ulcer | 1977 |
Beneficial effects of methionine and histidine in aspirin solutions on gastric mucosal damage in rats.
Topics: Animals; Aspirin; Drug Combinations; Gastric Mucosa; Histidine; Male; Methionine; Rats; Solutions; S | 1979 |
The effect of prostaglandin E2, 15-methyl prostaglandin E2, and metiamide on established canine gastric mucosal barrier damage.
Topics: Administration, Topical; Animals; Aspirin; Cell Membrane Permeability; Disease Models, Animal; Dogs; | 1979 |
Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers.
Topics: Animals; Aspirin; Cimetidine; Disease Models, Animal; Female; Gastric Mucosa; Guanidines; Rats; Stom | 1979 |
Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin.
Topics: Adult; Animals; Aspirin; Drug Evaluation, Preclinical; Gastric Mucosa; Glycyrrhiza; Humans; Male; Mi | 1979 |
Aspirin damage to ischemic gastric mucosa in shocked cats.
Topics: Administration, Topical; Animals; Aspirin; Cardiac Output; Cats; Female; Gastric Mucosa; Ischemia; M | 1979 |
[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)].
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Digestive Sy | 1979 |
Aspirin-induced glandular dysplasia of the stomach: histologic and histochemical studies in rats.
Topics: Animals; Aspirin; Cell Transformation, Neoplastic; Female; Gastric Mucosa; Pyloric Antrum; Rats; Sto | 1977 |
Biogenic amines in the pathogenesis of gastric ulceration induced by aspirin in rats.
Topics: Animals; Aspirin; Biogenic Amines; Female; Histamine Antagonists; Male; Rats; Stomach Ulcer; Sympath | 1977 |
Influence of aspirin on healing of chronic gastric ulcers in dogs.
Topics: Acetates; Animals; Aspirin; Chronic Disease; Dogs; Gastric Mucosa; Gastroscopy; Male; Peptic Ulcer P | 1977 |
Protection of gastric mucosa against aspirin-induced erosions by enhanced blood flow.
Topics: Animals; Aspirin; Dogs; Gastric Mucosa; Isoproterenol; Regional Blood Flow; Stomach Ulcer | 1977 |
Histamine augments gastric ulceration produced by intravenous aspirin in cats.
Topics: Animals; Aspirin; Cats; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; | 1978 |
A prospective comparative study of clinical and pathological characteristics in Icelandic and Danish patients with gastric ulcer, duodenal ulcer, and X-ray negative dyspepsia. II. Histological results.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Aspirin; Denmark; Duodenal Ulcer; Dyspepsia; Female; Gas | 1978 |
The role of aspirin in gastric ulceration . Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.
Topics: Animals; Arthritis, Experimental; Aspirin; Atropine Derivatives; Bethanechol Compounds; Cold Tempera | 1978 |
Effect of delta9-tetrahydrocannabinol on the gastrointestinal tract of the rat.
Topics: Animals; Aspirin; Digestive System; Dronabinol; Erythrocytes; Fasting; Feces; Gastric Mucosa; Male; | 1978 |
Influence of surgical sympathectomy on gastric secretion and ulceration in rats.
Topics: Acetates; Animals; Aspirin; Digestive System; Gastric Juice; Indomethacin; Male; Rats; Reserpine; Se | 1978 |
Effects of cold or restraint on incidence of gastric ulceration induced in rats by ulcerogenic drugs.
Topics: Animals; Aspirin; Cimetidine; Cold Temperature; Female; Histamine; Indomethacin; Male; Phenylbutazon | 1978 |
Cimetidine and prostaglandin prevent damage to gastric mucosa.
Topics: Animals; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gastri | 1978 |
Aspirin- and indomethacin-induced ulcers and their antagonism by antihistamines.
Topics: Animals; Aspirin; Cold Temperature; Corticosterone; Histamine Antagonists; Indomethacin; Male; Rats; | 1978 |
[Irritative activity of antiinflammatory agents, betamethasone 17-valerate, beclomethasone 17, 21-dipropionate, betamethasone 17, 21-dipropionate, or indomethacin on the gastrointestinal tract in rats and dogs (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Beclomethasone; Betamethasone; Betamethasone Valerate; C | 1978 |
[Comparative studies on gastrointestinal damage induced by non-steroidal anti-inflammatory drugs in rats (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dose-Response Relationship, Drug; Flurbiprofen; Indometh | 1978 |
Distention ulcer as a model for testing of drugs for ulcerogenic side effects.
Topics: Animals; Aspirin; Disease Models, Animal; Hydrochloric Acid; Indomethacin; Male; Rats; Stomach; Stom | 1978 |
Strain differences in aspirin-induced gastric ulceration in rats.
Topics: Animals; Aspirin; Esterases; Gastric Juice; Gastric Mucosa; Hexosamines; Ions; Male; Prothrombin Tim | 1978 |
Aspirin and gastric ulceration: light and electron microscopic observations in a model of aspirin plus stress-induced ulcerogenesis.
Topics: Animals; Aspirin; Gastric Mucosa; Hypothermia, Induced; Male; Microscopy, Electron; Rats; Stomach Ul | 1977 |
[Effects on the gastric mucosa of coated acetylsalicylic acid (Entrophen) and ordinary acetylsalicylic acid: comparative study by endoscopy].
Topics: Adult; Aspirin; Duodenum; Gastric Mucosa; Gastroscopy; Humans; Male; Stomach Ulcer; Tablets | 1977 |
Non-steroid anti-inflammatory drugs: combined assay for anti-edemic potency and gastric ulcerogenesis in the same animal.
Topics: Acacia; Adjuvants, Pharmaceutic; Animals; Aspartic Acid; Aspirin; Carrageenan; Diclofenac; Drug Eval | 1977 |
Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Gr | 1977 |
The turnover of mucin glycoprotein in the stomach.
Topics: Animals; Aspirin; Cells, Cultured; Chromatography, Gel; Dogs; Fasting; Gastric Mucosa; Glycoproteins | 1977 |
Effect of L-glutamine on acetylsalicylic acid-induced gastric lesions in pregnant and non-pregnant rats.
Topics: Animals; Aspirin; Female; Gastric Mucosa; Glutamine; Pregnancy; Pregnancy, Animal; Rats; Stomach Ulc | 1976 |
Effects of acetylsalicylic acid (ASA), ASA plus L-glutamine and L-glutamine on healing of chronic gastric ulcer in the rat.
Topics: Animals; Aspirin; Chronic Disease; Drug Evaluation, Preclinical; Glutamine; Male; Rats; Recurrence; | 1976 |
Effects of L-glutamine on various gastric lesions in rats and guinea pigs.
Topics: Animals; Aspirin; Drug Evaluation, Preclinical; Glutamine; Guinea Pigs; Histamine; Ligation; Male; p | 1976 |
Effects of carbenoxolone Na on acute and chronic gastric ulcer models in experimental animals.
Topics: Acute Disease; Animals; Aspirin; Carbenoxolone; Chronic Disease; Disease Models, Animal; Dogs; Gastr | 1976 |
Effects of various amino acids on gastric lesions induced by acetylsalicylic acid (ASA) and gastric secretion in pylorus-ligated rats.
Topics: Amino Acids; Animals; Aspirin; Gastric Juice; Ligation; Male; Pylorus; Rats; Stomach Ulcer | 1976 |
Some aspects in the pharmacology of diclonium bromide (2-(3,4-dicholoroanilino)quinolizinium bromide). Part II: Gastric acid-antisecretory and antiulcerogenic actions.
Topics: Animals; Aspirin; Atropine; Codeine; Ligation; Male; Papaverine; Parasympatholytics; Pylorus; Quinol | 1976 |
Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyc | 1976 |
Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cortisone; Cyclohexanecarboxylic Acids; Disease Model | 1976 |
[Case of profuse gastrointestinal hemorrhage after long-term administration of aspirin].
Topics: Adult; Aspirin; Humans; Male; Peptic Ulcer Hemorrhage; Stomach Ulcer; Time Factors | 1976 |
Hour-glass stomach: an explanation.
Topics: Adult; Aged; Aspirin; Constriction, Pathologic; Female; Humans; Male; Middle Aged; Sex Factors; Stom | 1976 |
Aspirin and prepyloric ulcer.
Topics: Achlorhydria; Aspirin; Humans; Male; Stomach Ulcer | 1976 |
Editorial: Aspirin and the transmucosal potential difference.
Topics: Animals; Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Membrane Potentials; Stomach | 1976 |
Upper gastrointestinal hemorrhage clinical, radiological and endoscopic correlation of 100 consecutive cases.
Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy; Esophageal Diseases; Ethanol; Female; Gastritis; Ga | 1976 |
The influence of aspirin on gastrointestinal microbleeding in dogs with gastric ulcers.
Topics: Administration, Oral; Animals; Aspirin; Dogs; Gastrointestinal Hemorrhage; Male; Stomach Ulcer | 1976 |
Gastric ulcer: natural history and treatment.
Topics: Adult; Aspirin; Australia; Boston; Carbenoxolone; Female; Gastrointestinal Hemorrhage; Glycyrrhiza; | 1976 |
Gastric damage by drugs and the role of the mucosal barrier.
Topics: Animals; Aspirin; Dogs; Ethanol; Gastric Mucins; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans | 1976 |
Floctafenine, a new non-narcotic analgesic.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Dextropropoxyphene; D | 1975 |
[Gastric ulcer induced in the rat by non-steroid anti-inflammatory agents and the synergic effect of exogenous histamine].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Drug Synergism; Flufenamic Acid; Histamine; Indomethacin | 1975 |
Factors relevant to the prognosis of chronic gastric ulcer.
Topics: Age Factors; Aspirin; Chronic Disease; Female; Follow-Up Studies; Humans; Male; Prognosis; Recurrenc | 1975 |
Hospital admissions for peptic ulcer during 1958-72.
Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Female; Hospitalization; Humans; Male; Middle Aged; P | 1976 |
Gastrocolic fistula as a complication of benign gastric ulcer.
Topics: Adult; Aged; Aspirin; Barium Sulfate; Colonic Diseases; Colonic Neoplasms; Diagnosis, Differential; | 1976 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and | 1976 |
Editorial: Aspirin and chronic gastric ulcer.
Topics: Adult; Aspirin; Australia; Chronic Disease; Female; Humans; Middle Aged; Stomach Ulcer; Substance-Re | 1976 |
Alcohol, aspirin, depression, smoking, stress and the patient with a gastric ulcer.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Aspirin; Chronic Disease; Depression; Ethnicity; Female; | 1976 |
Gastric ulceration associated with aspirin ingestion in an achlorhydric patient: a case report.
Topics: Achlorhydria; Arthritis, Rheumatoid; Aspirin; Gastric Mucosa; Gastroscopy; Humans; Male; Middle Aged | 1976 |
Letter: Aspirin and chronic gastric ulcer.
Topics: Animals; Aspirin; Chronic Disease; Humans; Stomach Ulcer | 1976 |
Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Dose-Response Relationship, Drug; Ethanol; Gastric | 1992 |
Effect of the calcium channel blockers cinnarizine and flunarizine on gastric histamine content in rats with experimentally-induced ulcers.
Topics: Animals; Aspirin; Calcium Channel Blockers; Cinnarizine; Female; Flunarizine; Gastric Mucosa; Histam | 1992 |
Mechanism of the protective action of interleukin-1 in the experimental gastric damage in the rat.
Topics: Animals; Aspirin; Epoprostenol; Gastric Mucosa; Interleukin-1; Rats; Stomach Ulcer | 1992 |
Antiulcer and gastric secretory activity of N-phthaloyl gamma-aminobutyric acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Ulcer Agents; Aspirin; Bicuculline; Ethanol; gamma-Aminobuty | 1992 |
Seasonal fluctuations in acute upper gastrointestinal bleeding: lack of effect of nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Emergencies; Esophagitis; Gastriti | 1992 |
Gastric changes in coronary-operated patients with low-dose aspirin.
Topics: Adult; Aged; Aspirin; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Fe | 1992 |
Effect of aspirin on ulcer site blood flow in cat stomachs.
Topics: Animals; Aspirin; Cats; Dose-Response Relationship, Drug; Female; Hydrochloric Acid; Regional Blood | 1992 |
Synthesis and antiulcer activity of novel 5-(2-ethenyl substituted)-3(2H)-furanones.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Ethanol; Furans; Indomethacin; Male; Molecular Str | 1992 |
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bridged Bicyclo Compounds; Cyclooxygenase | 1992 |
Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids.
Topics: Adrenalectomy; Animals; Aspirin; Dexamethasone; Dinoprostone; Edema; Epoprostenol; Gastric Acid; Gas | 1992 |
Multiple mechanisms in the action of alpha-CGRP in rat stomach.
Topics: Animals; Aspirin; Calcitonin Gene-Related Peptide; Gastric Acid; Gastric Mucosa; Humans; Pentagastri | 1992 |
Changes in cyclic AMP content of rat gastric mucosa induced by ulcerogenic stimuli--in relation to the antiulcer activity of irsogladine maleate.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Bucladesine; Cyclic AMP; Gastric Acid; Gastric Mucosa; Male; Py | 1991 |
[The part of lysosomal enzymes in drug-induced ulcerogenesis].
Topics: Animals; Aspirin; Cathepsins; Deoxyribonucleases; Indomethacin; Lysosomes; Male; Phenylbutazone; Qui | 1991 |
Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Gastric Acid; Gastric Mucosa; Histamine H1 Antagonist | 1991 |
A reliable method for the production of antral gastric ulcer by a combination of 2-deoxy-D-glucose, aspirin and ammonia in rats.
Topics: Administration, Oral; Ammonia; Animals; Aspirin; Deoxyglucose; Disease Models, Animal; Drug Interact | 1991 |
Regulation of epidermal growth factor receptors in rat gastric mucosa: effect of gastric ulceration.
Topics: Animals; Aspirin; DNA; Epidermal Growth Factor; ErbB Receptors; Gastric Mucosa; Male; Rats; Rats, In | 1991 |
Experimental reactivation of chronic gastric lesions exposed to different aggressive conditions.
Topics: Acetates; Animals; Aspirin; Chronic Disease; Ethanol; Female; Gastric Acid; Gastric Mucosa; Random A | 1991 |
Aggravation by the capsaicin-treatment of gastric antral ulcer induced by the combination of 2-deoxy-D-glucose, aspirin and ammonia in rats.
Topics: Ammonia; Animals; Aspirin; Capsaicin; Deoxyglucose; Gastric Acid; Gastric Mucosa; Male; Nerve Degene | 1991 |
Nocloprost, a unique PGE2 analog, with local gastroprotective and ulcer healing activity.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Female; Gastric Mucosa; Male; Prostaglandins F, Synthetic; Rats | 1991 |
Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Dog Diseases; Dogs; Double-Blind Method; Gastrit | 1991 |
[Prevention of associated gastropathy with non-steroidal antirheumatic agents].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Stomach Ulcer | 1991 |
Effect of calcitonin gene-related peptide (CGRP) on aspirin- and ethanol-induced injury in the rat stomach.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Bicarbonates; Calcitonin Gene-Related Peptide; Electrodes; Etha | 1991 |
Antisecretory and anti-ulcer effects of morphine in rats after gastric mucosal aggression.
Topics: Animals; Aspirin; Depression, Chemical; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Morphine; | 1991 |
Protection against gastric ulcer by verapamil.
Topics: Animals; Aspirin; Cold Temperature; Female; Gastric Acid; Male; Pylorus; Rats; Restraint, Physical; | 1991 |
Effect of zinc acexamate on gastric lesions induced by aspirin: a morphological study.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Aspirin; Carrageenan; Chromatography, | 1990 |
[Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)].
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carnosine; Dogs; Duodenal Ulcer; Epirizole; Ethanol; Gastric Ac | 1990 |
[Protective effect of colloidal bismuth subcitrate on gastric mucosal lesion induced by aspirin].
Topics: Adolescent; Adult; Anti-Ulcer Agents; Aspirin; Dinoprostone; Female; Gastric Mucosa; Humans; Male; O | 1990 |
Research on heterocyclic compounds. XXVI. Antiinflammatory and related activities of some 2-phenylimidazo[1,2-b]pyridazines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Carrageenan; | 1990 |
Overt gastrointestinal bleeding in the course of chronic low-dose aspirin administration for secondary prevention of arterial occlusive disease.
Topics: Aged; Arterial Occlusive Diseases; Aspirin; Female; Gastritis; Gastrointestinal Hemorrhage; Humans; | 1990 |
Mucosal protective activity of activated aluminum complex.
Topics: Aluminum Hydroxide; Animals; Antacids; Aspirin; Cysteamine; Duodenal Ulcer; Ethanol; Gastric Mucosa; | 1990 |
Effect of piracetam, a nootropic agent, on experimental gastric ulcers in rat.
Topics: Animals; Aspirin; Female; Male; Piracetam; Pyrrolidinones; Rats; Rats, Inbred F344; Stomach Ulcer | 1990 |
Gastric protective activity of mixtures of saturated polar and neutral lipids in rats.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Aspirin; Bile Acids and Salts; Drug Combinations; Ethan | 1990 |
Asymptomatic gastric damage by drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Stomach Ulcer | 1990 |
Misoprostol prevents damage to the gastric mucosa by stabilizing the mast cells.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Guinea Pigs; Histamine; H | 1987 |
[Influence of sucrose on aspirin ulcer].
Topics: Animals; Aspirin; Drug Interactions; Duodenal Ulcer; Rats; Stomach Ulcer; Sucrose | 1989 |
Slow release delivery of rioprostil by an osmotic pump inhibits the formation of acute aspirin-induced gastric lesions in dogs and accelerates the healing of chronic lesions without incidence of side effects.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Chronic Disease; Dogs; Fem | 1989 |
Evaluation of the gastric antiulcerogenic effects of Solanum nigrum, Brassica oleracea and Ocimum basilicum in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Gastric Acid; Hexosamines; Male; Pepsin A; Plant Extracts; Rats | 1989 |
Gastric antisecretory and antiulcer/cytoprotective effects of 2-cyano-3-(ethylthio-3-methylthio)-2-propenoic acid methyl ester.
Topics: Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cyanoacrylates; Ethanol; | 1989 |
Effect of BMY-25368, a potent and long-acting histamine H2-receptor antagonist, on gastric secretion and aspirin-induced gastric lesions in the dog.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Dogs; Dose-Response Relationship, Drug; | 1989 |
Gastroprotective activity of ginger zingiber officinale rosc., in albino rats.
Topics: Animals; Aspirin; Drugs, Chinese Herbal; Ethanol; Female; Hydrochloric Acid; Indomethacin; Male; Rat | 1989 |
[Anti-ulcer effect of extract from phellodendri cortex].
Topics: Animals; Aspirin; Drugs, Chinese Herbal; Ethanol; Gastric Juice; Ligation; Male; Rats; Stomach Ulcer | 1989 |
Aspirin-induced gastric mucosal damage in dogs: protection by the prostanoid Ro 22-1327.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Dogs; Female; Gastric Acid; Gastric Mucosa; Gastroscopy; Male; | 1989 |
Role of leukotrienes and platelet activating factor in acute gastric mucosal lesions in rats.
Topics: Animals; Aspirin; Chromones; Diterpenes; Ethanol; Gastric Mucosa; Ginkgolides; Lactones; Leukotriene | 1989 |
Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Epirizole; Ethanol; Gastric Acid; Gastric Mucosa; Imm | 1989 |
Cytoprotective and antiulcer activities of the antacid magaldrate in the rat.
Topics: Aluminum Hydroxide; Animals; Antacids; Anti-Ulcer Agents; Aspirin; Cell Survival; Cysteamine; Dinopr | 1989 |
Potentiation of aspirin-induced gastric lesions by exposure to cold in rats. Role of acid secretion, mucosal blood flow, and gastric mucosal prostanoid content.
Topics: Animals; Aspirin; Cold Temperature; Female; Gastric Acid; Gastric Mucosa; Male; Prostaglandins; Rats | 1989 |
Peptic ulcer disease: physiology and pathophysiology.
Topics: Antacids; Aspirin; Bismuth; Duodenal Ulcer; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; | 1985 |
Effects of N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)-acetoxyacetamide hydrochloride (TZU-0460), a histamine H2-receptor antagonist, on gastric acid secretion and ulcer formation.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Cysteamine; Dogs; Gastric Acid; Histamine; Histamine | 1985 |
Gastric mucus glycoprotein in different rat strains.
Topics: Animals; Aspirin; Carbohydrates; Glycoproteins; Male; Mucus; Rats; Rats, Inbred Strains; Species Spe | 1986 |
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di | 1987 |
Gastric anti-ulcer and cytoprotective effect of selenium in rats.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Dimaprit; Ethanol; Female; Gastric Acid; Gastric | 1988 |
Biochemical background of the development of gastric mucosal damage in pylorus-ligated plus aspirin-treated rats.
Topics: Absorption; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspirin | 1986 |
Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Diterpenes; Endotoxins; Ethanol; Female; Gastric Mucosa; Ginkgo | 1988 |
Actions of nizatidine on the rat uterus, dog stomach and experimentally induced gastric lesions.
Topics: Animals; Aspirin; Atropine; Dogs; Duodenum; Female; Gastrointestinal Motility; Guanidines; Guinea Pi | 1986 |
Hyperosmolar glucose prevents stress ulceration in the rat restraint model despite inhibition of endogenous prostaglandins.
Topics: Animals; Aspirin; Blood Glucose; Cyclooxygenase Inhibitors; Enteral Nutrition; Gastric Mucosa; Gluco | 1987 |
Prevention of acute gastric mucosal lesions by Solcoseryl.
Topics: Actihaemyl; Animals; Aspirin; Ethanol; Female; Gastric Acid; Gastric Mucosa; Male; Pepsin A; Rats; R | 1987 |
Misoprostol attenuates aspirin-induced changes in potential difference and associated damage in canine gastric mucosa.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; DNA; Dogs; Dose-Response Relationship, Drug; Epith | 1987 |
Antithrombotic and ulcerogenic effects of fenflumizole, a new anti-inflammatory imidazole derivative, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspiri | 1987 |
Altered susceptibility of arthritic rats to the gastric lesion-inducing effects of aspirin or ethanol and the antilesion effect of rioprostil.
Topics: Animals; Anti-Ulcer Agents; Arthritis; Arthritis, Experimental; Aspirin; Ethanol; Male; Prostaglandi | 1987 |
Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Dogs; Female; Gastric Mucosa; Male; Misoprostol; R | 1988 |
[Fluorescence polarization studies of rat gastric surfactant: effects of aspirin].
Topics: Animals; Aspirin; Chemical Phenomena; Chemistry, Physical; Fluorescence Polarization; Gastric Mucosa | 1988 |
Aspirin and bleeding peptic ulcers in the elderly.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle | 1988 |
Stimulation of mucus production and prevention of aspirin induced ulcerogenesis by enprostil in the rat.
Topics: Animals; Aspirin; Enprostil; Female; Gastric Mucosa; Male; Mucus; Prostaglandins E, Synthetic; Rats; | 1988 |
[Changes in stomach and duodenal mucosa caused by acetylsalicylic acid therapy].
Topics: Aspirin; Dose-Response Relationship, Drug; Duodenal Ulcer; Duodenum; Female; Gastric Mucosa; Humans; | 1988 |
Role of leukotrienes in acute gastric lesions induced by ethanol, taurocholate, aspirin, platelet-activating factor and stress in rats.
Topics: Animals; Aspirin; Chromones; Dinoprostone; Ethanol; Female; Gastric Mucosa; Male; Platelet Activatin | 1988 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal | 1988 |
Synthesis and antiulcer activity of (isochroman-1-yl)alkylamines. I.
Topics: Amines; Animals; Anti-Ulcer Agents; Aspirin; Benzopyrans; Chemical Phenomena; Chemistry; Chromans; G | 1988 |
Novel method for producing standard subacute gastric ulcer in rats and for the quantitative evaluation of the healing process. Effect of several drugs on healing.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Disease | 1988 |
Further studies on the role of the adrenals in the capsaicin-sensitive "gastric defence mechanism".
Topics: Adrenal Glands; Animals; Aspirin; Capsaicin; Drug Synergism; Ethanol; Indomethacin; Rats; Rats, Inbr | 1988 |
Pathogenesis of gastric mucosal injury.
Topics: Aspirin; Ethanol; Gastric Mucosa; Stomach Ulcer | 1988 |
Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; In | 1988 |
[Pharmacological studies on the effects of some traditional Chinese medicines on gastric functions. (3) The effects of oren-gedoku-to (OGT), san'o-syasin-to (SST), antyu-san (AS) and dai-saiko-to (DST) on ethanol- and aspirin-induced gastric lesions in ra
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; Male; Peptic Ulc | 1988 |
Gastric protection by sucralfate. Role of mucus and prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Dinoprost; Dinoprostone | 1986 |
Protective effects of the prostaglandins on the gastric mucosa.
Topics: Animals; Aspirin; Cricetinae; Dinoprostone; Gastric Acid; Gastric Mucosa; Humans; Intestinal Mucosa; | 1986 |
Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins.
Topics: Animals; Aspirin; Dinoprostone; Ethanol; Gastric Juice; Gastric Mucosa; Organometallic Compounds; Pr | 1987 |
Pharmacological activity of FPP028 (2-phenylpyrazolo-4-ethyl-4,7-dihydro [1,5a]pyrimidin-7-one) a new non-steroid anti-inflammatory agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1986 |
Is an acid pH medium required for the protective effect of sucralfate against mucosal injury?
Topics: Animals; Aspirin; Bile Acids and Salts; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; H | 1987 |
Gastric protection by meciadanol. A new synthetic flavonoid inhibiting histidine decarboxylase.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Aspirin; Benzopyrans; Carboxy-Lyases; Ca | 1986 |
Focal gastric mucosal blood flow in aspirin-induced ulceration.
Topics: Acute Disease; Animals; Aspirin; Dogs; Electrodes; Female; Gastric Mucosa; Hydrogen; Ischemia; Male; | 1987 |
Molecular weight of gastric mucus glycoprotein is a determinant of the degree of subsequent aspirin induced chronic gastric ulceration in the rat.
Topics: Amino Acids; Animals; Aspirin; Carbohydrates; Chromatography, Gel; Chronic Disease; Gastric Mucosa; | 1987 |
Efficacy of sucralfate in preventing peptic ulceration induced by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Indomethacin; Male; Peptic Ulcer; Rats; S | 1987 |
[Experimental findings on gastric ulcerogenicity and mucosa protection by benzydamine in the rat].
Topics: Animals; Aspirin; Benzydamine; Ethanol; Gastric Mucosa; Male; Pyrazoles; Rats; Rats, Inbred Strains; | 1987 |
Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.
Topics: Animals; Aspirin; Gastric Acid; Hypothermia; Indomethacin; Ligation; Male; Morphine Dependence; Pylo | 1987 |
Studies on the gastroprotective and ulcer-healing effects of colloidal bismuth subcitrate.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Aspirin; Immersion; Organometallic Compo | 1987 |
Role of endogenous gastric mucosal prostaglandins in the formation of acute gastric mucosal lesions induced by aspirin, ethanol, HCl and CH3COOH.
Topics: Acetates; Acute Disease; Administration, Oral; Animals; Aspirin; Ethanol; Gastric Mucosa; Hydrochlor | 1987 |
[Pharmacological studies of some blended traditional Chinese medicines on gastric functions. (1). The effects of oren-gedoku-to (OGT), san'o-syasin-to (SST), antyu-san (AS) and dai-saiko-to (DST) on ethanol- and aspirin-induced injury of gastric mucosal b
Topics: Animals; Aspirin; Ethanol; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Pl | 1987 |
[Histomorphologic studies of the detection of disordered barrier function of the gastric mucosa].
Topics: Animals; Aspirin; Epithelium; Gastric Mucosa; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; | 1987 |
[Chronic upper abdominal pain with iron-deficiency anemia and analgesic-induced hemorrhaging stomach ulcers: duodenal wall carcinoid without flush symptoms].
Topics: Adult; Anemia, Hypochromic; Aspirin; Carcinoid Tumor; Duodenal Neoplasms; Duodenum; Humans; Male; Mi | 1987 |
Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats.
Topics: Acetates; Acetic Acid; Administration, Oral; Animals; Arbaprostil; Aspirin; Dose-Response Relationsh | 1986 |
Gastrocolic fistula.
Topics: Adult; Aspirin; Colonic Diseases; Female; Gastric Fistula; Humans; Intestinal Fistula; Stomach Ulcer | 1986 |
Peptic ulcer and non-steroidal anti-inflammatory agents.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Female; Humans; Male; Middle | 1986 |
Antiulcer and gastroprotective effects of solon, a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Chalcone; Chalcones; Ethanol; Female; Gastric Juice; Indomethac | 1986 |
Prostaglandins and cellular restitution in the gastric mucosa.
Topics: Animals; Aspirin; Cell Movement; Ethanol; Gastric Mucosa; Microcirculation; Microscopy, Electron, Sc | 1986 |
Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration.
Topics: Animals; Aspirin; Benzofurans; Ethanol; Gastric Mucosa; Intestinal Mucosa; Lignans; Male; Platelet A | 1986 |
Ulcerogenic and antiulcerogenic effects of a new antiinflammatory drug, the gamma-lactone-N-ethyl derivative of 6-[1S-(3S,4-dihydro-8-hydroxy-1H-2-benzo- pyran-1-one-3-yl)-3-methylbutylamino]-4S,5S-dihydroxy-6-oxo-3S- ammoniohexanoate, on gastrointestinal
Topics: Animals; Anti-Ulcer Agents; Aspirin; Coumarins; Gastrointestinal Motility; Indomethacin; Isocoumarin | 1986 |
Fatal antral ulcer in conventionally fed W/Wv mutant mice given indomethacin by injection.
Topics: Animals; Aspirin; Dinoprostone; Disease Susceptibility; Fasting; Gastric Mucosa; Indomethacin; Injec | 1985 |
Gastric mucosal protection by spizofurone.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Dinoprostone; Electrolytes; Ethanol; Gastric Mucos | 1985 |
Ulcer formation and cytoprotection by acetazolamide.
Topics: 16,16-Dimethylprostaglandin E2; Acetazolamide; Animals; Aspirin; Dinoprostone; Ethanol; Female; Gast | 1985 |
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cime | 1985 |
Reduction in gastric mucosal hemorrhage and ulceration with chronic high-level dosing of enteric-coated aspirin granules two and four times a day.
Topics: Adolescent; Adult; Aspirin; Drug Administration Schedule; Duodenum; Female; Gastric Mucosa; Gastroin | 1985 |
Analgesic, anti-inflammatory and oxy-radical scavenger activity of imidazole and imidazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Edema; Gastritis | 1985 |
Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate.
Topics: Animals; Aspirin; Cats; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Female; Histamine; In | 1985 |
Structural damage and changes in eicosanoid metabolites in the gastric mucosa of rats and pigs induced by anti-inflammatory drugs of varying ulcerogenicity.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Diflunisal; Gastric Mucosa; Indomethacin; Membrane Poten | 1986 |
S.E.M. study II: Protective effect of ranitidine against gastric and duodenal lesions induced by non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Duodenal Ulcer; Endoscopy; Female; Humans; Male; Microscop | 1986 |
Effect of domperidone on experimentally induced gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Domperidone; Female; Gastric Mucosa; Male; Phenylbutazone; Rats | 1986 |
Focal gastric mucosal blood flow at the site of aspirin-induced ulceration.
Topics: Animals; Aspirin; Dogs; Gastric Mucosa; Hyperemia; Methods; Regional Blood Flow; Stomach; Stomach Ul | 1985 |
Antiplatelet aggregators inhibit development of stress ulcers in Sprague-Dawley rats.
Topics: Animals; Anticoagulants; Aspirin; Capillaries; Dipyridamole; Gastric Mucosa; Male; Platelet Aggregat | 1985 |
A quantitative method for assessing the extent of experimental gastric erosions and ulcers.
Topics: Animals; Aspirin; Chemical Phenomena; Chemistry; Ethanol; Female; Gastric Mucosa; Microscopy; Rats; | 1985 |
Effect of nicotine and caffeine pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone, and reserpine in rats.
Topics: Administration, Oral; Animals; Aspirin; Caffeine; Drug Synergism; Female; Gastric Mucosa; Male; Nico | 1985 |
Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Eating; Female; Indomethacin; Intestinal Disease | 1985 |
Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms.
Topics: Acetaminophen; Alcohol Drinking; Analgesics; Anti-Inflammatory Agents; Aspirin; Chronic Disease; Fem | 1985 |
Comments on "The ulcerogenic potential of copper aspirinate seems to be more imaginary than real".
Topics: Animals; Aspirin; Rats; Stomach Ulcer | 1985 |
Effect of elcatonin on experimental gastric and duodenal ulcers.
Topics: Acetates; Acetic Acid; Actihaemyl; Animals; Anti-Ulcer Agents; Aspirin; Calcitonin; Cimetidine; Cyst | 1985 |
Studies on biological activities of melanin from marine animals. III. Inhibitory effect of SM II (low molecular weight melanoprotein from squid) on phenylbutazone-induced ulceration in gastric mucosa in rats, and its mechanism of action.
Topics: Animals; Aspirin; Decapodiformes; Gastric Mucosa; Invertebrate Hormones; Male; Melanins; Phenylbutaz | 1985 |
Effect of nicotine, alcohol and caffeine pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine in rats.
Topics: Animals; Aspirin; Caffeine; Drug Interactions; Ethanol; Female; Gastric Mucosa; Male; Nicotine; Phen | 1985 |
Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers.
Topics: Acetates; Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Aspirin; Benzofurans; Chronic Dise | 1985 |
Effects of intracerebroventricular bombesin on gastric ulcers and gastric glycoproteins in rats.
Topics: Animals; Aspirin; Bombesin; Chromatography, Gel; Gastric Acid; Gastric Mucosa; Glycoproteins; Indome | 1985 |
Letter: Methylprostaglandin e2 methyl ester and gastric-ulcer healing.
Topics: Animals; Aspirin; Esters; Gastroscopy; Humans; Prostaglandins; Rats; Stomach Ulcer; Wound Healing | 1974 |
Inhibitory effect of L-glutamine on the aspirin-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Duodenum; Gastric Juice; Gastric Mucosa; Glutamine; Hydrogen | 1974 |
Pharmacology of zolimidine (2-(p-methylsulfonylphenyl)-imidazo (1,2-a) pyridine) a new non-anticholinergic gastroprotective agent. II) Protective activity against drug-induced experimental ulcers.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Guinea Pigs; Histamine; Histamine H1 Antagon | 1974 |
Pharmacology of zolimidine (2-(p-methylsulfonylphenyl)-imidazo (1,2-a) pyridine) a new non-anticholinergic gastroprotective agent. IV) Enhancement of gastric mucus production in different experimental models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cold Temperature; Gastric Mucins; Gastric Mu | 1974 |
Environmental factors and the Australian gastric ulcer change.
Topics: Adrenal Cortex Hormones; Adult; Alcohol Drinking; Aspirin; Australia; Disabled Persons; Duodenal Ulc | 1969 |
Gastric mucosal injury by anti-inflammatory drugs.
Topics: Adrenocorticotropic Hormone; Animals; Aspirin; Cortisone; Dogs; Female; Gastric Mucosa; Humans; Male | 1967 |
[The fate of 165 hemorrhagic ulcers treated in a special intensive care unit].
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Emergencies; Esoph | 1973 |
Anti-inflammatory drugs in rheumatic diseases.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin | 1974 |
Evaluation of the potential of gastric ulceration after administration of certain drugs.
Topics: Amines; Aminopyrine; Animals; Ascorbic Acid; Aspirin; Chlorpromazine; Cortisone; Desoxycorticosteron | 1967 |
Effect of a single dose of phentolamine and mj 1999 on aspirin-induced gastric ulceration in rats.
Topics: Anilides; Animals; Aspirin; Female; Male; Phentolamine; Rats; Stomach Ulcer; Sulfonic Acids; Sympath | 1969 |
The resistance of guinea-pigs to cortisone ulcerogenesis.
Topics: Animals; Aspirin; Cortisone; Fasting; Guinea Pigs; Male; Stomach Ulcer | 1969 |
[Pharmacological studies on clonixin. 1. Anti-inflammatory and analgesic actions and effects on the gastrointestinal tract].
Topics: Acetylcholine; Aminopyrine; Analgesics; Aniline Compounds; Animals; Anti-Inflammatory Agents; Aspiri | 1971 |
Effect of some natural substances on ulceration of the rat stomach caused by acetysalicycic acid.
Topics: Animals; Aspirin; Flavonoids; Gastric Mucosa; Plant Extracts; Psyllium; Quercetin; Rats; Stomach Ulc | 1974 |
Erosive gastritis with special reference to the role of aspirin and bile.
Topics: Acute Disease; Age Factors; Aged; Animals; Aspirin; Bile; Chronic Disease; Drainage; Female; Gastrec | 1974 |
Effects of an antiulcer agent N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat.
Topics: Acetates; Aluminum; Animals; Aspirin; Atropine; Duodenal Ulcer; Glutamine; Male; Rats; Stomach Ulcer | 1974 |
Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rat.
Topics: Amylopectin; Animals; Aspirin; Atropine; Bicarbonates; Drug Interactions; Gastric Mucosa; Glutamine; | 1974 |
Effects of phentolamine mesylate and propranolol hydrochloride on aspirin-induced gastric lesions and gastric secretions in the rat.
Topics: Animals; Aspirin; Body Weight; Gastric Mucosa; Male; Phentolamine; Propranolol; Pylorus; Rats; Stoma | 1974 |
Influence of L-glutamine on aspirin-induced gastric lesions and absorptions as well as antipyretic, analgesic and anti-inflammatory effects of aspirin in rats and mice.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Glutamine; Intestinal | 1974 |
Effects of salicylates on the canine stomach: a morphological and histochemical study.
Topics: Administration, Oral; Animals; Aspirin; Autopsy; Autoradiography; Biopsy; Body Weight; Dogs; Epithel | 1972 |
Acute gastro-intestinal haemorrhage. Prognostic factors on a conservative regime.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Child; Child, Preschool; Du | 1972 |
Gastric mucosal damage by anti-inflammatory drugs.
Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diffusion; Gastric Mucins; Gastric Mucosa; Gastritis; | 1972 |
Effects of the non-steroidal antiphlogistics on the gastric mucosal barrier and hexosamine content in rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biological Transport; Carboxylic Acids; Chlorine; Cycloh | 1972 |
[Ulcers of the gastroduodenal tract due to drugs. Apropos of a personal experience].
Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Aspirin; Duodenal Ulcer; Female; Gastrointestinal | 1972 |
Aspirin use in patients with major upper gastrointestinal bleeding and peptic-ulcer disease. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.
Topics: Adult; Aged; Aspirin; Boston; Drug Evaluation; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage; | 1974 |
[Gastro-duodenal tolerance of some drugs with analgesic effect. Clinico-endoscopic considerations].
Topics: Analgesics; Anti-Inflammatory Agents; Antimalarials; Aspirin; Digestive System; Duodenal Ulcer; Esop | 1974 |
Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one (W-2395).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoxazi | 1974 |
Proceedings: Effects of L-glutamine and other amino acids on aspirin-induced gastric lesions in rats.
Topics: Amino Acids; Animals; Aspirin; Glutamine; Rats; Stomach Ulcer | 1974 |
The first Walter Bradford Cannon lecture before the Society of Gastro-intestinal Radiologists.
Topics: Animals; Aspirin; Bile; Blood Proteins; Digestion; Dogs; Gastric Mucosa; Histamine Release; History, | 1973 |
[Clinical significance of the so-called gastric mucous barrier].
Topics: Animals; Aspirin; Atropine; Dogs; Ethanol; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; H | 1974 |
Effects of thiocyanate and acetylsalicylic acid on the gastric mucosal barrier in rats.
Topics: Administration, Oral; Animals; Aspirin; Biological Transport; Carbonic Anhydrase Inhibitors; Carboni | 1972 |
[Gastric erosions and ulcerations in gastritis caused by drugs].
Topics: Aminopyrine; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastritis; Gastroscopy; Gluco | 1972 |
The Berry Lecture. Studies of the gastric mucosal barrier--its relevance to clinical gastric disease.
Topics: Animals; Aspirin; Dogs; Epithelium; Female; Gastric Mucins; Gastric Mucosa; Gastritis; Humans; Hydro | 1972 |
Gastric and duodenal ulceration associated with aspirin ingestion.
Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Endoscopy; Female; Gastroscopy; Humans; Male; Middle Aged; Sto | 1973 |
[Experimental gastric ulceration. Rapid method of induction in the rat by combined drug treatment].
Topics: Aminopyrine; Animals; Aspirin; Drug Combinations; Histamine; ortho-Aminobenzoates; Phenylbutazone; R | 1973 |
Correlation of mucosal histology and aspirin intake in chronic gastric ulcer.
Topics: Adult; Aged; Aspirin; Caffeine; Chronic Disease; Epithelium; Female; Gastric Mucosa; Gastritis; Huma | 1973 |
Chronic gastric ulcer induced by aspirin: an experimental model.
Topics: Animals; Aspirin; Chronic Disease; Disease Models, Animal; Gastric Juice; Gastric Mucosa; Glycoprote | 1973 |
Prevention of aspirin-induced gastric ulceration by bile duct or pylorus ligation in the rat.
Topics: Administration, Oral; Animals; Aspirin; Bile; Common Bile Duct; Female; Gastric Mucosa; Ligation; Ma | 1973 |
Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Biological Transport, Active; Cell Membrane Permeability; Chl | 1974 |
Letter: Aspirin, gastritis, and antral ulcers.
Topics: Arthritis, Rheumatoid; Aspirin; Biopsy; Drug Combinations; Female; Gastritis; Gastroscopy; Humans; I | 1974 |
Upper gastrointestinal disease in rheumatoid arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Arizona; Arthritis, Rheumatoid; Aspir | 1974 |
Proceedings: The effects of aspirin, carbenoxolone, and gefarnate on the gastric mucosal potential difference in man.
Topics: Aspirin; Electric Conductivity; Fatty Acids, Unsaturated; Gastric Acidity Determination; Gastric Muc | 1974 |
Aspirin ingestion and perforated peptic ulcer.
Topics: Aspirin; Duodenal Ulcer; Female; Humans; Male; Peptic Ulcer Perforation; Sex Factors; Stomach Ulcer; | 1972 |
Hydrogen permeability of canine gastric secretory epithelium during formation of acute superficial erosions.
Topics: Animals; Aspirin; Biological Transport; Dogs; Female; Gastric Mucosa; Hydrogen; Male; Potassium; Sho | 1971 |
Effect of histamine and aspirin on healing of standardized gastric ulcers in dogs.
Topics: Acetates; Animals; Aspirin; Dogs; Endoscopy; Gastric Mucosa; Gastroscopy; Granulation Tissue; Histam | 1971 |
The analgesic powder.
Topics: Abnormalities, Drug-Induced; Anemia; Aspirin; Blood Platelet Disorders; Female; Humans; Infant, Newb | 1971 |
Effects of aspirin on gastric mucosae of albino rat and Mongloian gerbil (Meriones unguiculatus).
Topics: Administration, Oral; Animals; Aspirin; Gastric Mucosa; Gerbillinae; Male; Rats; Rats, Inbred Strain | 1971 |
Serial endoscopic observation of the effects of histamine, aspirin, steroids, and alcohol on standardized gastric ulcers in dogs.
Topics: Acetates; Animals; Aspirin; Dogs; Ethanol; Gastroscopy; Histamine; Methods; Methylprednisolone; Stom | 1971 |
[Gastric ulcers produced by an association of ulcerogenic drugs and restraint].
Topics: Animals; Aspirin; Female; Immobilization; Male; Methylprednisolone; Phenylbutazone; Pyrazoles; Rats; | 1971 |
[Comparative study on the ulcerogenous effect of various antiphlogistic agents].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Female; Gastric Mucosa; Indomethacin; Prednisone; Rats; | 1971 |
Lesions associated with gastroduodenal haemorrhage, in relation to aspirin intake.
Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans; | 1968 |
Problems in the management of massive hemorrhage from the esophagogastrointestinal tract.
Topics: Aged; Angiography; Aspirin; Cineradiography; Diverticulum, Colon; Endoscopy; Esophageal and Gastric | 1970 |
Gastric absorption and distribution of acetylsalicylic acid and other acidic compounds in the rat.
Topics: Acetates; Acids; Animals; Aspirin; Autoradiography; Barbiturates; Benzoates; Carbon Isotopes; Chroma | 1970 |
Gastrointestinal haemorrhage, gastric ulcer and aspirin.
Topics: Acute Disease; Adult; Age Factors; Aged; Aspirin; Australia; Diagnosis, Differential; Female; Gastro | 1970 |
Aspirin and gastrointestinal bleeding.
Topics: Aspirin; Chronic Disease; Female; Gastrointestinal Hemorrhage; Humans; Melena; Stomach Ulcer | 1970 |
Comparison of gastric toxicity of acetylsalicylic acid with route of administration in the rat.
Topics: Animals; Aspirin; Disease Models, Animal; Gastric Acidity Determination; Gastric Juice; Gastric Muco | 1971 |
Aspirin and alcohol in gastrointestinal haemorrhage.
Topics: Aspirin; Drug Synergism; Duodenal Ulcer; Esophageal and Gastric Varices; Ethanol; Female; Gastritis; | 1971 |
Perforated peptic ulcer.
Topics: Adult; Age Factors; Aspirin; Australia; Duodenal Ulcer; Female; Follow-Up Studies; Gastrectomy; Huma | 1969 |
The incidence of aspirin ingestion in patients with peptic ulcer.
Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Caffeine; Child; Duodenal Ulcer; Female; H | 1970 |
Gastric mucosal blood flow following damage by ethanol, acetic acid, or aspirin.
Topics: Acetates; Aminopyrine; Animals; Aspirin; Dogs; Ethanol; Gastric Lavage; Gastric Mucosa; Peptic Ulcer | 1970 |
Effect of histamine and aspirin on healing of acute acetic acid ulcers.
Topics: Acetates; Animals; Aspirin; Dogs; Histamine; Stomach Ulcer; Wound Healing | 1970 |
Personality pattern and emotional stress in the genesis of gastric ulcer.
Topics: Aggression; Alcohol Drinking; Anxiety; Aspirin; Female; Humans; Life Style; Male; Personality; Perso | 1970 |
[Soluble and injectable aspirin (lysine acetylsalicylate). Contribution to the study of digestive accidents with acetylsalicylic acid].
Topics: Absorption; Adult; Animals; Aspirin; Dogs; Gastric Mucosa; Gastritis; Humans; Injections, Intravenou | 1970 |
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. II. Toxicological and general pharmacological properties.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Autonomic Nervous System; Blood Circulation; Blood Gluco | 1970 |
Aspirin-induced gastrointestinal lesions in dogs.
Topics: Animals; Aspirin; Dog Diseases; Dogs; Duodenal Ulcer; Female; Gastrointestinal Diseases; Male; Stoma | 1968 |
Gastric ulcer, duodenal ulcer and gastric carcinoma: a case-control study of certain social and environmental factors.
Topics: Adult; Aged; Alcohol Drinking; Aspirin; Australia; Divorce; Duodenal Ulcer; Educational Status; Fami | 1968 |
[Round table discussion of gastric ulcer].
Topics: Aspirin; Cortisone; Duodenal Diseases; Gastric Juice; Gastritis; Humans; Ischemia; Stomach Ulcer; St | 1968 |
Aspirin and uncomplicated peptic ulcer.
Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Child; Duodenal Ulcer; Female; Humans; Mal | 1969 |
Gastric and duodenal ulcer. The association between aspirin ingestion, smoking and family history of ulcer.
Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Australia; Duodenal Ulcer; Female; Humans; Male; Midd | 1969 |
The relationship between perforated peptic ulcer and aspirin ingestion.
Topics: Aged; Aspirin; Duodenal Ulcer; Dyspepsia; Female; Humans; Male; Middle Aged; Peptic Ulcer Perforatio | 1965 |
[Histochemical study of experimental gastric lesions induced by acetylsalicylic acid and other drugs in rats].
Topics: Animals; Aspirin; Rats; Stomach Ulcer | 1966 |
Multiple peptic ulcers after salicylate ingestion.
Topics: Aged; Aspirin; Duodenal Ulcer; Female; Humans; Stomach Ulcer | 1966 |
[Medicinal ulcers of the greater gastric curvature. Thoughts apropos of 2 cases].
Topics: Aged; Aspirin; Humans; Male; Middle Aged; Phenylbutazone; Sodium Salicylate; Stomach Ulcer; Triamcin | 1966 |