aspirin has been researched along with Gastric Diseases in 161 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study compared the effects of frequently used anti-platelet drugs, such as clopidogrel, ticlopidine, and cilostazol, on the gastric bleeding and ulcerogenic responses induced by intraluminal perfusion with 25 mM aspirin acidified with 25 mM HCl (acidified ASA) in rats." | 7.80 | Comparative effects of the anti-platelet drugs, clopidogrel, ticlopidine, and cilostazol on aspirin-induced gastric bleeding and damage in rats. ( Izuhara, C; Takayama, S; Takeuchi, K, 2014) |
| " The in vivo antithrombotic property of ibudilast (CAS 50847-11-5), a phosphodiesterase 4 (PDE4) inhibitor, was evaluated in a photochemically-induced guinea pig carotid artery thrombosis model in combination with low-dose ASA." | 7.78 | Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury. ( Hoshina, K; Manita, S; Matsuzawa, S; Miyata, Y; Ooie, T; Sasahara, T; Sueyoshi, S; Yasue, T, 2012) |
| "Previous erosive oesophagitis studies have excluded patients with peptic ulcers or taking aspirin, and conflicting results have been reported concerning the influence of." | 7.71 | Correlation between erosive oesophageal and gastro-duodenal diseases. the influence of aspirin, simple analgesics, and Helicobacter pylori. ( Angerson, WJ; Morran, CG; Taha, AS, 2002) |
| "We studied 30 patients with postsurgical ulcer and aspirin abuse." | 7.70 | Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer. ( Hirschowitz, BI; Lanas, A, 1998) |
| "Ninety-one normal, healthy volunteers participated in a single-center, double-blind, placebo-controlled, randomized, parallel group study: 1) to compare the prostaglandin E1 analog, misoprostol, given at a dose of 200 micrograms bid, with the recommended dose of 200 micrograms qid in protecting the gastroduodenal mucosa against injury due to anti-inflammatory doses of aspirin (3900 mg/day); and 2) to determine whether the reduced dose was associated with a lesser incidence of gastrointestinal (GI) side effects, particularly diarrhea." | 5.07 | A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits. ( Deysach, LG; Geis, GS; Kochman, RL; Lanza, FL; Rack, EM, 1991) |
| "Three randomized, placebo-controlled multiclinic trials involving arbaprostil dosages of (a) 10 micrograms; (b) 25 micrograms; and (c) 10, 25, or 50 micrograms orally for 4 wk in patients older than 18 yr with rheumatoid arthritis or osteoarthritis who had endoscopically documented nonsteroidal antiinflammatory drug-associated gastric mucosal damage were conducted in the United States." | 5.06 | A report of three multiclinic trials evaluating arbaprostil in arthritic patients with ASA/NSAID gastric mucosal damage. The Upjohn Company Arbaprostil ASA/NSAID Gastric Mucosal Damage Treatment Study Groups. ( Champion, C; Euler, AR; Fleischmann, R; Jaszewski, R; Le, V; Rao, J; Raskin, J; Razzaque, M; Safdi, M; Welsh, J, 1990) |
| "Based on current references four clinical scenarios were discussed and different management strategies were compared for secondary and primary prophylaxis of ulcer or peptic ulcer bleeding under continuous therapy with non-steroidal antiinflammatory drugs (NSAID) or low-dose-aspirin, for H." | 4.82 | [Secondary and primary prophylaxis of gastropathy associated with nonsteroidal antiinflammatory drugs or low-dose-aspirin: a review based on four clinical scenarios]. ( Ittel, TH; Limmer, S; Wietholtz, H, 2003) |
| "Although figures vary considerably, the ingestion of aspirin or other non-aspirin non-steroidal anti-inflammatory drugs is associated with an increased risk of gastric ulceration, ulcer bleeding, ulcer complications and of death by a factor of around 3." | 4.79 | Nonsteroidal anti-inflammatory drug-induced gastric damage: epidemiology. ( Langman, MJ; Shorrock, CJ, 1995) |
| "96) as well as history of hematemesis, melena in the past 30 days, positive nasogastric aspirate, prior upper gastrointestinal bleeding or use of aspirin or non-steroidal anti-inflammatory." | 3.83 | Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics. ( Camus, M; Dulai, GS; Ghassemi, KA; Jensen, DM; Jutabha, R; Khungar, V; Kovacs, TO; Machicado, GA; Ohning, GV, 2016) |
| "The present study compared the effects of frequently used anti-platelet drugs, such as clopidogrel, ticlopidine, and cilostazol, on the gastric bleeding and ulcerogenic responses induced by intraluminal perfusion with 25 mM aspirin acidified with 25 mM HCl (acidified ASA) in rats." | 3.80 | Comparative effects of the anti-platelet drugs, clopidogrel, ticlopidine, and cilostazol on aspirin-induced gastric bleeding and damage in rats. ( Izuhara, C; Takayama, S; Takeuchi, K, 2014) |
| " The in vivo antithrombotic property of ibudilast (CAS 50847-11-5), a phosphodiesterase 4 (PDE4) inhibitor, was evaluated in a photochemically-induced guinea pig carotid artery thrombosis model in combination with low-dose ASA." | 3.78 | Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury. ( Hoshina, K; Manita, S; Matsuzawa, S; Miyata, Y; Ooie, T; Sasahara, T; Sueyoshi, S; Yasue, T, 2012) |
| "Previous erosive oesophagitis studies have excluded patients with peptic ulcers or taking aspirin, and conflicting results have been reported concerning the influence of." | 3.71 | Correlation between erosive oesophageal and gastro-duodenal diseases. the influence of aspirin, simple analgesics, and Helicobacter pylori. ( Angerson, WJ; Morran, CG; Taha, AS, 2002) |
| "We studied 30 patients with postsurgical ulcer and aspirin abuse." | 3.70 | Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer. ( Hirschowitz, BI; Lanas, A, 1998) |
| " Dogs treated with aspirin developed NSAID-induced gastropathy (including gastric ulceration), and the degree of endoscopically detectable damage correlated well with sucrose permeability." | 3.69 | Noninvasive detection of nonsteroidal anti-inflammatory drug-induced gastropathy in dogs. ( Kirk, D; Meddings, JB; Olson, ME, 1995) |
| "A prospective endoscopic study was carried out in 65 patients with rheumatoid arthritis to assess the prevalence of gastroduodenal lesions on aspirin alone or aspirin plus another anti-inflammatory drug (n = 26)." | 3.66 | Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. An endoscopic assessment. ( Butt, JH; Grandione, J; Hewitt, J; Holt, SD; Ivey, KJ; Morris, AD; Silvoso, GR; Tatum, W, 1981) |
| "Trehalose has several novel anti-inflammatory and cell-protective functions." | 2.77 | Lyophilized aspirin with trehalose may decrease the incidence of gastric injuries in healthy dogs. ( Chung, UI; Echigo, R; Kamata, H; Kayasuga, Y; Lin, LS; Mochizuki, M; Sasaki, N; Shimohata, N; Suzuki, S, 2012) |
| "Lafutidine is an H2-receptor antagonist with gastroprotective activity, produced by acting on capsaicin-sensitive afferent neurons." | 2.75 | Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study. ( Asaka, M; Imai, A; Kamada, G; Kato, M; Nakagawa, M; Nakagawa, S; Nishida, U; Ono, S; Shimizu, Y; Yamamoto, K; Yoshida, T, 2010) |
| "pylori gastritis was present than when it was absent, despite similar degrees of gastric mucosal prostaglandin depletion." | 2.70 | Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial. ( Cryer, B; Feldman, M; Go, MF; Mallat, D, 2001) |
| "5, 1, 2, 3 and 4 h after dosing to evaluate eight upper gastrointestinal symptoms, which were stomach pain, burning sensation, nausea, heartburn, gas, burping, indigestion and upset stomach." | 2.69 | Subjective gastrointestinal tolerability of acetylsalicylic acid and paracetamol after single dose treatment. ( Amin, D; Elfström, C; Grahnén, A; Loose, I; Nilsson, LG; Rolfsen, W, 1999) |
| " In contrast, in study 2 significantly higher total gastroduodenal mucosal lesion scores were observed on day 1 after the first dose and after 7 days of dosing with plain ASA (mean sum of the lesion scores in the gastric fundus, body, antrum and in the duodenal bulb: day 1: plain ASA 3." | 2.69 | Enteric coating of aspirin significantly decreases gastroduodenal mucosal lesions. ( Burkhardt, F; Dammann, HG; Wolf, N, 1999) |
| " The data indicate that ticlopidine is better tolerated by the gastroduodenal mucosa than low dosage aspirin." | 2.67 | [A comparison of the gastroduodenal tolerance of ticlopidine and acetylsalicylic acid]. ( Kleinsorge, H; Müller, P; Simon, B, 1993) |
| " An initial dose-response study in 48 subjects showed that 200- and 400-mg doses of cimetidine conferred a sufficient reduction in gastric mucosal injury to warrant further study." | 2.66 | Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine. ( Chapman, RC; Kimmey, MB; Saunders, DR; Silverstein, FE, 1987) |
| "Aspirin effects were studied with and without previous treatment with cimetidine." | 2.64 | Protective effect of cimetidine on aspirin-induced gastric mucosal damage. ( Baskin, WN; Ivey, KJ; Krause, WJ; MacKercher, PA, 1977) |
| "Aspirin was used to induce damage in the morning, while XJZD was applied as an intervention in the afternoon." | 2.44 | Mechanism of Xiaojianzhong decoction in alleviating aspirin-induced gastric mucosal injury revealed by transcriptomics and metabolomics. ( Bao, SC; Chen, J; Chen, T; Hu, X; Li, JT; Liang, Y; Wei, HL; Yan, SG; Zhang, JX; Zhou, XY, 2024) |
| " This dose-response effect, evident in both endoscopic and microbleeding studies done after acute or short-term aspirin administration, is also associated with the risk of developing chronic gastric ulcer." | 2.37 | Aspirin and the stomach. ( Graham, DY; Smith, JL, 1986) |
| " These results suggest that even the acute use of an NSAID (regardless of COX-2 selectivity) can induce gastric damage when combined with the long-term use of low-dose aspirin in an animal model." | 1.43 | Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy. ( Baglie, S; Baller, EM; Franco, GC; Gevert, MV; Lupepsa, AC; Moro, MG; Sanchez, PK; Tostes, AF, 2016) |
| "The risk of postoperative hemorrhage following gastric ESD was higher in patients with antithrombotic therapy than in those without that therapy." | 1.39 | The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. ( Edogawa, S; Harada, S; Higuchi, K; Kojima, Y; Ota, K; Takeuchi, T; Tokioka, S; Umegaki, E, 2013) |
| "Aspirin is known to produce severe adverse gastrointestinal effects, such as bleeding and perforation." | 1.33 | Minidose aspirin and gastrointestinal bleeding--a retrospective, case-control study in hospitalized patients. ( Eliakim, R; Fishman, M; Hershkovici, M; Niv, Y; Sapoznikov, B; Vilkin, A, 2005) |
| "Uninvestigated dyspepsia is common in family practice." | 1.32 | The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment - Prompt Endoscopy (CADET-PE) study. ( Armstrong, D; Barkun, AN; Chakraborty, B; Chiba, N; Daniels, S; Escobedo, S; Sinclair, P; Thomson, AB; Van Zanten, SJ; White, RJ, 2003) |
| "We compared the gastric toxic effect of aspirin (ASA) in both normal and diabetic rats, with that of NCX-4016, a derivative of ASA with nitric oxide (NO) releasing moiety." | 1.31 | Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. ( Fujita, A; Takeuchi, K; Tashima, K; Umeda, M, 2000) |
| " 4) The pectin-induced increase of gastric lesions (number) showed a dose-response effect." | 1.30 | Effects of pectin-induced passive linkage of gastric H+ on the gastric acid secretion on the development of ethanol- and salicylate-induced gastric mucosal lesions in rats. ( Figler, M; Mózsik, G; Szabó, I, 1999) |
| "Pretreatment with indomethacin, which is a prostaglandin synthesis inhibitor and idoacetamide, which is a sulfhydryl blocker did not influence the inhibited ethanol lesion of WBS." | 1.30 | Prevention of ethanol-induced gastric lesions in rats by wu-bei-san. ( Lin, WC, 1998) |
| "of rioprostil were 61 and 52% lower, respectively, than the mean severity score in the vehicle-treated group." | 1.28 | Rioprostil prevents aspirin-induced fecal blood loss in dogs. Correlation of Hemoquant (Hb) with endoscopic findings. ( Fernandez, JA; Katz, LB; Schwartz, S; Shriver, DA, 1989) |
| " Gross bleeding from the pouch treated with ASA was never observed with the concomitant dosing of ASA and L-glutamine 50 or 100 mM." | 1.26 | Effects of L-glutamine on acetylsalycylic acid induced gastric lesions and acid back diffusion in dogs. ( Hung, CR; Murata, T; Okabe, S; Takagi, K; Takeuchi, K, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (51.55) | 18.7374 |
| 1990's | 37 (22.98) | 18.2507 |
| 2000's | 18 (11.18) | 29.6817 |
| 2010's | 20 (12.42) | 24.3611 |
| 2020's | 3 (1.86) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 3 |
| Zhang, J | 2 |
| Chen, T | 3 |
| Bao, S | 2 |
| Li, J | 2 |
| Wei, H | 3 |
| Hu, X | 3 |
| Liang, Y | 3 |
| Liu, F | 1 |
| Yan, S | 2 |
| Bao, SC | 1 |
| Zhang, JX | 1 |
| Wei, HL | 1 |
| Zhou, XY | 1 |
| Li, JT | 1 |
| Yan, SG | 1 |
| Ventura, H | 1 |
| Valkhoff, VE | 1 |
| Sturkenboom, MC | 1 |
| Hill, C | 1 |
| Veldhuyzen van Zanten, S | 1 |
| Kuipers, EJ | 1 |
| Iijima, K | 4 |
| Iwabuchi, T | 3 |
| Ara, N | 4 |
| Koike, T | 4 |
| Shinkai, H | 2 |
| Kamata, Y | 2 |
| Ichikawa, T | 2 |
| Ishihara, K | 2 |
| Shimosegawa, T | 4 |
| Nishino, M | 1 |
| Sugimoto, M | 1 |
| Uotani, T | 1 |
| Yamade, M | 1 |
| Sahara, S | 1 |
| Ichikawa, H | 2 |
| Sugimoto, K | 1 |
| Umemura, K | 1 |
| Watanabe, H | 1 |
| Miyajima, H | 1 |
| Furuta, T | 1 |
| Takeuchi, T | 1 |
| Ota, K | 1 |
| Harada, S | 1 |
| Edogawa, S | 1 |
| Kojima, Y | 1 |
| Tokioka, S | 1 |
| Umegaki, E | 1 |
| Higuchi, K | 1 |
| Rotondano, G | 2 |
| Cipolletta, L | 1 |
| Koch, M | 1 |
| Bianco, MA | 1 |
| Grossi, E | 1 |
| Marmo, R | 1 |
| Takeuchi, K | 6 |
| Takayama, S | 1 |
| Izuhara, C | 1 |
| Telaku, S | 1 |
| Kraja, B | 1 |
| Qirjako, G | 1 |
| Prifti, S | 1 |
| Fejza, H | 1 |
| Mu, FH | 1 |
| Hu, FL | 1 |
| Zhang, YY | 1 |
| Yang, GB | 1 |
| Lei, XY | 1 |
| Yang, YP | 1 |
| Sun, WN | 1 |
| Cui, MH | 1 |
| Kanbayashi, Y | 1 |
| Konishi, H | 1 |
| Camus, M | 1 |
| Khungar, V | 1 |
| Jensen, DM | 1 |
| Ohning, GV | 1 |
| Kovacs, TO | 1 |
| Jutabha, R | 1 |
| Ghassemi, KA | 1 |
| Machicado, GA | 1 |
| Dulai, GS | 1 |
| Guo, W | 1 |
| Lu, W | 1 |
| Xu, Y | 1 |
| Wang, L | 1 |
| Wei, Q | 1 |
| Zhao, Q | 1 |
| Moro, MG | 1 |
| Sanchez, PK | 1 |
| Gevert, MV | 1 |
| Baller, EM | 1 |
| Tostes, AF | 1 |
| Lupepsa, AC | 1 |
| Baglie, S | 1 |
| Franco, GC | 1 |
| Bayramli, G | 1 |
| Ulutas, B | 1 |
| Lai, LH | 1 |
| Chan, FK | 1 |
| Kato, M | 1 |
| Kamada, G | 1 |
| Yamamoto, K | 1 |
| Nishida, U | 1 |
| Imai, A | 1 |
| Yoshida, T | 1 |
| Ono, S | 1 |
| Nakagawa, M | 1 |
| Nakagawa, S | 1 |
| Shimizu, Y | 1 |
| Asaka, M | 1 |
| Abe, Y | 3 |
| Iwai, W | 2 |
| Uno, K | 2 |
| Asano, N | 2 |
| Imatani, A | 1 |
| Ohara, S | 1 |
| Endo, H | 1 |
| Lin, LS | 1 |
| Kayasuga, Y | 1 |
| Shimohata, N | 1 |
| Kamata, H | 1 |
| Suzuki, S | 1 |
| Echigo, R | 1 |
| Mochizuki, M | 1 |
| Chung, UI | 1 |
| Sasaki, N | 1 |
| Matsuzawa, S | 1 |
| Hoshina, K | 1 |
| Sueyoshi, S | 1 |
| Miyata, Y | 1 |
| Manita, S | 1 |
| Ooie, T | 1 |
| Yasue, T | 1 |
| Sasahara, T | 1 |
| Taha, AS | 1 |
| Angerson, WJ | 1 |
| Morran, CG | 1 |
| Thomson, AB | 1 |
| Barkun, AN | 1 |
| Armstrong, D | 1 |
| Chiba, N | 1 |
| White, RJ | 1 |
| Daniels, S | 1 |
| Escobedo, S | 1 |
| Chakraborty, B | 1 |
| Sinclair, P | 1 |
| Van Zanten, SJ | 1 |
| Limmer, S | 1 |
| Ittel, TH | 1 |
| Wietholtz, H | 1 |
| WATERSON, AP | 1 |
| MELLEMGAARD, L | 1 |
| LANGE, HF | 2 |
| STUBBE, LT | 1 |
| MUIR, A | 2 |
| COSSAR, IA | 2 |
| EDELMANN, G | 1 |
| PLEWINSKI, G | 1 |
| GASPARDY, G | 1 |
| VIDA, M | 1 |
| BANYAI, B | 1 |
| DAVENPORT, HW | 1 |
| MENGUY, RB | 1 |
| MASTERS, YF | 1 |
| Dammann, HG | 2 |
| Saleki, M | 1 |
| Torz, M | 1 |
| Schulz, HU | 1 |
| Krupp, S | 1 |
| Schürer, M | 1 |
| Timm, J | 1 |
| Gessner, U | 1 |
| Brzozowski, T | 5 |
| Konturek, PC | 1 |
| Moran, AP | 1 |
| Pajdo, R | 1 |
| Kwiecien, S | 1 |
| Konturek, SJ | 6 |
| Sliwowski, Z | 1 |
| Drozdowicz, D | 2 |
| Pawlik, WW | 1 |
| Hahn, EG | 1 |
| Fries, JF | 1 |
| Murtagh, KN | 1 |
| Bennett, M | 1 |
| Zatarain, E | 1 |
| Lingala, B | 1 |
| Bruce, B | 1 |
| Sapoznikov, B | 1 |
| Vilkin, A | 1 |
| Hershkovici, M | 1 |
| Fishman, M | 1 |
| Eliakim, R | 1 |
| Niv, Y | 1 |
| Fiorucci, S | 1 |
| Antonelli, E | 1 |
| Distrutti, E | 1 |
| Rizzo, G | 1 |
| Mencarelli, A | 1 |
| Orlandi, S | 1 |
| Zanardo, R | 1 |
| Renga, B | 1 |
| Di Sante, M | 1 |
| Morelli, A | 1 |
| Cirino, G | 1 |
| Wallace, JL | 1 |
| Isozaki, Y | 1 |
| Yoshida, N | 2 |
| Kuroda, M | 1 |
| Kokura, S | 1 |
| Naito, Y | 2 |
| Okanoue, T | 1 |
| Yoshikawa, T | 2 |
| Chen, JT | 1 |
| Pucino, F | 1 |
| Resman-Targoff, BH | 1 |
| Walker, J | 1 |
| Robinson, J | 1 |
| Stewart, J | 1 |
| Jacob, S | 1 |
| Nishizawa, T | 1 |
| Suzuki, H | 1 |
| Masaoka, T | 1 |
| Hibi, T | 1 |
| Morris, E | 1 |
| Noujaim, AA | 1 |
| Miya, TS | 1 |
| Christian, JE | 1 |
| Hoftiezer, JW | 1 |
| Silvoso, GR | 3 |
| Burks, M | 1 |
| Ivey, KJ | 5 |
| Reele, SB | 1 |
| Gumbleton, TJ | 1 |
| Stryd, RP | 1 |
| Brunden, MN | 1 |
| Gilbertson, TJ | 1 |
| Börsch, G | 1 |
| Schmidt, G | 1 |
| Ganote, DP | 2 |
| Hennings, G | 1 |
| Lücker, PW | 2 |
| Bruhn, R | 1 |
| Vance, J | 1 |
| Procaccini, RL | 1 |
| Bretagne, JF | 1 |
| Feuillu, A | 1 |
| Gosselin, M | 1 |
| Gastard, J | 1 |
| Piastucki, I | 1 |
| Radecki, T | 1 |
| Dembiński, A | 2 |
| Dembińska-Kieć, A | 1 |
| Duggan, JM | 2 |
| Morris, AD | 1 |
| Holt, SD | 2 |
| Hewitt, J | 1 |
| Tatum, W | 1 |
| Grandione, J | 1 |
| Butt, JH | 2 |
| Krantz, JC | 1 |
| Visconti, G | 1 |
| Spotti, D | 1 |
| Piperno, A | 1 |
| Marini, U | 1 |
| Guth, PH | 2 |
| Baldi, E | 1 |
| Caruso, I | 1 |
| Bianchi Porro, G | 1 |
| Tabata, K | 1 |
| Okabe, S | 5 |
| Robins, PG | 1 |
| McGreevy, JM | 1 |
| Moody, FG | 1 |
| Bielanski, W | 1 |
| Schally, AV | 1 |
| Stachura, J | 2 |
| Konturek, J | 1 |
| Domschke, W | 2 |
| Palacios, B | 1 |
| Montero, MJ | 1 |
| Sevilla, MA | 1 |
| Román, LS | 1 |
| Shorrock, CJ | 1 |
| Langman, MJ | 1 |
| Savon, JJ | 1 |
| Allen, ML | 1 |
| DiMarino, AJ | 1 |
| Hermann, GA | 1 |
| Krum, RP | 1 |
| Konturek, JW | 1 |
| Stoll, R | 1 |
| Morimoto, Y | 1 |
| Oshima, S | 1 |
| Hara, H | 1 |
| Sukamoto, T | 1 |
| Perkins, WE | 1 |
| Bianchi, RG | 1 |
| Tremont, SJ | 1 |
| Collins, PW | 1 |
| Casler, JJ | 1 |
| Fenton, RL | 1 |
| Wagner, GM | 1 |
| McGrath, MP | 1 |
| Stolzenbach, JC | 1 |
| Kowalski, DL | 1 |
| Levy, G | 1 |
| Fireman, Z | 1 |
| Mittelman, M | 1 |
| Lurie, B | 1 |
| Simon, B | 1 |
| Kleinsorge, H | 1 |
| Müller, P | 1 |
| Schubert, TT | 1 |
| Bologna, SD | 1 |
| Nensey, Y | 1 |
| Schubert, AB | 1 |
| Mascha, EJ | 1 |
| Ma, CK | 1 |
| Meddings, JB | 1 |
| Kirk, D | 1 |
| Olson, ME | 1 |
| Payen, JL | 1 |
| Cales, P | 1 |
| Pienkowski, P | 1 |
| Sozzani, P | 1 |
| Kervran, A | 1 |
| Frexinos, J | 1 |
| Pascal, JP | 1 |
| Cook, GA | 1 |
| Elliott, SL | 1 |
| Skeljo, MV | 1 |
| Giraud, AS | 1 |
| Yeomans, ND | 2 |
| Kordecki, H | 1 |
| Kurowski, M | 1 |
| Kosik, R | 1 |
| Pilecka, D | 1 |
| Hirschowitz, BI | 1 |
| Lanas, A | 1 |
| Lin, WC | 1 |
| García-Sancho Martín, L | 1 |
| Dibuz, M | 1 |
| Szabó, T | 1 |
| Monoki, E | 1 |
| Nagymélykuti, L | 1 |
| Illyés, M | 1 |
| Varga, E | 1 |
| Csípö, L | 1 |
| Suzuki, K | 1 |
| Yamamoto, H | 1 |
| Araki, H | 1 |
| Mizoguchi, H | 1 |
| Ukawa, H | 1 |
| Herrerías Gutiérrez, JM | 1 |
| Elfström, C | 1 |
| Amin, D | 1 |
| Nilsson, LG | 1 |
| Grahnén, A | 1 |
| Rolfsen, W | 1 |
| Loose, I | 1 |
| Burkhardt, F | 1 |
| Wolf, N | 1 |
| Figler, M | 1 |
| Szabó, I | 1 |
| Mózsik, G | 1 |
| Schenck, J | 1 |
| Müller, CH | 1 |
| Lübbers, H | 1 |
| Mahlke, R | 1 |
| Lehnick, D | 1 |
| Lankisch, PG | 1 |
| Tashima, K | 1 |
| Fujita, A | 1 |
| Umeda, M | 1 |
| Yagi, N | 1 |
| Matsuyama, K | 1 |
| Seto, K | 1 |
| Yoneta, T | 1 |
| Feldman, M | 1 |
| Cryer, B | 1 |
| Mallat, D | 1 |
| Go, MF | 1 |
| Rainsford, KD | 2 |
| Brune, K | 1 |
| Hung, CR | 1 |
| Murata, T | 1 |
| Takagi, K | 3 |
| MacKercher, PA | 2 |
| Baskin, WN | 2 |
| Krause, WJ | 2 |
| Speranza, V | 1 |
| Lezoche, E | 1 |
| Molinari, F | 1 |
| Daino, G | 1 |
| Honda, K | 1 |
| Menguy, R | 3 |
| Lockard, OO | 1 |
| Sisk, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy[NCT05553717] | 66 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| Sclerotherapy With Polidocanol Foam in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease in Patients With Liver Cirrhosis: A Prospective, Cohort Trial[NCT05807425] | Phase 2/Phase 3 | 40 participants (Anticipated) | Interventional | 2023-03-31 | Recruiting | ||
| Video Capsule Endoscopy for Lesion Localization and Diagnosis in Patients With Severe Hematochezia[NCT03616041] | 50 participants (Anticipated) | Observational | 2021-02-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 reviews available for aspirin and Gastric Diseases
| Article | Year |
|---|---|
Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.
Topics: Animals; Aspirin; Ferroptosis; Gastric Mucosa; Iron; Kelch-Like ECH-Associated Protein 1; Mice; NF-E | 2022 |
Low-dose acetylsalicylic acid use and the risk of upper gastrointestinal bleeding: a meta-analysis of randomized clinical trials and observational studies.
Topics: Aspirin; Cardiovascular Diseases; Duodenal Diseases; Esophageal Diseases; Gastrointestinal Hemorrhag | 2013 |
Epidemiology and diagnosis of acute nonvariceal upper gastrointestinal bleeding.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy, Gastr | 2014 |
Nonsteroid anti-inflammatory drug-induced gastroduodenal injury.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Drug Inter | 2009 |
[Secondary and primary prophylaxis of gastropathy associated with nonsteroidal antiinflammatory drugs or low-dose-aspirin: a review based on four clinical scenarios].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Gastrointestinal | 2003 |
Celecoxib versus a non-selective NSAID plus proton-pump inhibitor: what are the considerations?.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Decisi | 2006 |
Does enteric-coated aspirin result in a lower incidence of gastrointestinal complications compared to normal aspirin?
Topics: Aspirin; Coronary Artery Bypass; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Posto | 2007 |
[Drug-induced lesions in the upper gastrointestinal tract].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Cheilitis; Drug-Rela | 1984 |
[The most common drugs considered harmful to the stomach, Clinical and endoscopic studies].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Dyspepsia; Fema | 1980 |
Pathogenesis of gastric mucosal injury.
Topics: Animals; Aspirin; Bile Acids and Salts; Bile Reflux; Ethanol; Gastric Juice; Gastric Mucosa; Gastrit | 1982 |
Pathologic basis of gastric mucosal adaptation to topical injury.
Topics: Adaptation, Physiological; Alcoholism; Animals; Aspirin; Gastric Mucosa; Humans; Regeneration; Risk | 1995 |
Nonsteroidal anti-inflammatory drug-induced gastric damage: epidemiology.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Ulcer; Humans; M | 1995 |
[Aspirin and the gastric mucosa--a new look at an old problem].
Topics: Animals; Aspirin; Gastric Mucosa; Humans; Peptic Ulcer Hemorrhage; Stomach Diseases; Stomach Ulcer | 1993 |
[Gastric and duodenal intramural hematoma: report of two cases].
Topics: Adult; Aspirin; Chronic Disease; Duodenal Diseases; Gastric Mucosa; Hematoma; Humans; Intestinal Muc | 1998 |
[Innocuous NSAID: myth or reality?].
Topics: Adult; Age Factors; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Vessels; | 1998 |
The biochemical pathology of aspirin-induced gastric damage.
Topics: Age Factors; Alcohol Drinking; Animals; Anti-Inflammatory Agents; Ascorbic Acid Deficiency; Aspirin; | 1975 |
[The gastric mucosa barrier and gastropathy].
Topics: Alcoholic Beverages; Aspirin; Bile Acids and Salts; Gastric Juice; Gastric Mucosa; Histamine Release | 1978 |
Analgesics and the stomach.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Indometha | 1976 |
Aspirin and other platelet active drugs. Relationship among dose, effectiveness, and side effects.
Topics: Aspirin; Blood Platelets; Dipyridamole; Epoprostenol; Gastrointestinal Hemorrhage; Humans; Platelet | 1989 |
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Humans; Stomach Diseases | 1989 |
Incidence of gastropathy in destructive arthropathies.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Esophagus; Female; Gastrointestinal H | 1989 |
Nonsteroidal anti-inflammatory drug gastropathy. Recognition and response.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Humans; Stomach Diseases | 1987 |
Aspirin and the stomach.
Topics: Acute Disease; Adaptation, Physiological; Anemia; Animals; Aspirin; Buffers; Chronic Disease; Dose-R | 1986 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
Nonsteroidal anti-inflammatory drugs (first of two parts).
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Drug Hypersensitivity; Gastric | 1974 |
Gastroenterology in Australia, 1949-69.
Topics: Animals; Aspirin; Australia; Colitis, Ulcerative; Copper; Gastric Juice; Gastroenterology; Gastroint | 1970 |
[Aspirin and gastric hemorrhage].
Topics: Aspirin; Gastrointestinal Hemorrhage; Humans; Stomach Diseases | 1970 |
23 trials available for aspirin and Gastric Diseases
| Article | Year |
|---|---|
Relationship between Adverse Gastric Reactions and the Timing of Enteric-Coated Aspirin Administration.
Topics: Aged; Aged, 80 and over; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Administ | 2017 |
Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study.
Topics: Acetamides; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Ove | 2010 |
Lyophilized aspirin with trehalose may decrease the incidence of gastric injuries in healthy dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Dog | 2012 |
Effects of buffered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric mucosa in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Aspirin; Cross-Over Stu | 2004 |
Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man.
Topics: Adult; Aspirin; Duodenal Diseases; Duodenum; Erythema; Gastric Mucosa; Humans; Intestinal Mucosa; Py | 1980 |
[Aspirin and gastroduodenal toxicity. A double-blind endoscopic study of the effects of placebo, aspirin and lysine acetylsalicylate in healthy subjects].
Topics: Adult; Aspirin; Double-Blind Method; Duodenal Diseases; Duodenum; Endoscopy; Female; Gastric Mucosa; | 1984 |
Gastrointestinal blood loss with low dose (325 mg) plain and enteric-coated aspirin administration.
Topics: Adaptation, Physiological; Adult; Aspirin; Cross-Over Studies; Female; Gastrointestinal Hemorrhage; | 1995 |
[A comparison of the gastroduodenal tolerance of ticlopidine and acetylsalicylic acid].
Topics: Adult; Aspirin; Double-Blind Method; Gastric Mucosa; Humans; Male; Purpura; Stomach Diseases; Stomac | 1993 |
Weakness of mucosal barrier in portal hypertensive gastropathy of alcoholic cirrhosis. Effects of propranolol and enprostil.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Anti-Ulcer Agents; Aspirin; Dinoprostone; Enprostil; Femal | 1995 |
Subjective gastrointestinal tolerability of acetylsalicylic acid and paracetamol after single dose treatment.
Topics: Acetaminophen; Adult; Algorithms; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Female; Hu | 1999 |
Enteric coating of aspirin significantly decreases gastroduodenal mucosal lesions.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Double-Blind Method; Du | 1999 |
Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trial.
Topics: Adolescent; Adult; Antibodies, Bacterial; Aspirin; Blood Platelets; Cyclooxygenase 1; Double-Blind M | 2001 |
Protective effect of cimetidine on aspirin-induced gastric mucosal damage.
Topics: Adult; Aspirin; Cimetidine; Gastric Mucosa; Guanidines; Humans; Hydrogen-Ion Concentration; Male; So | 1977 |
Effect of glucagon on aspirin-induced gastric mucosal damage in man.
Topics: Adult; Aspirin; Blood Glucose; Electrophysiology; Epithelium; Female; Gastric Mucosa; Glucagon; Huma | 1978 |
Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding.
Topics: Adult; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control | 1991 |
Aspirin-induced gastric mucosal damage: prevention by enteric-coating and relation to prostaglandin synthesis.
Topics: Adult; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastric | 1991 |
A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits.
Topics: Adult; Aspirin; Diarrhea; Double-Blind Method; Duodenal Diseases; Duodenoscopy; Female; Gastric Muco | 1991 |
A report of three multiclinic trials evaluating arbaprostil in arthritic patients with ASA/NSAID gastric mucosal damage. The Upjohn Company Arbaprostil ASA/NSAID Gastric Mucosal Damage Treatment Study Groups.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aluminum Hydroxide; Anti-Inflammatory Agents, | 1990 |
Cimetidine decreases aspirin-induced gastric mucosal damage in humans.
Topics: Adult; Aspirin; Cimetidine; Double-Blind Method; Female; Gastric Mucosa; Gastroscopy; Humans; Male; | 1987 |
Comparative evaluation of gastrointestinal intolerance produced by plain and tri-buffered aspirin tablets.
Topics: Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Gases; Heartburn; Humans; Mal | 1988 |
Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine.
Topics: Acute Disease; Adolescent; Adult; Aspirin; Cimetidine; Clinical Trials as Topic; Dose-Response Relat | 1987 |
Ethanol, aspirin, ibuprofen, and the gastroduodenal mucosa: an endoscopic assessment.
Topics: Adult; Aspirin; Drug Interactions; Drug Synergism; Duodenal Diseases; Ethanol; Female; Gastric Mucos | 1985 |
Aspirin injury to the gastric mucosa. Gastrocamera observations of the effect of pH.
Topics: Adult; Aspirin; Bicarbonates; Clinical Trials as Topic; Female; Gastric Acidity Determination; Gastr | 1968 |
111 other studies available for aspirin and Gastric Diseases
| Article | Year |
|---|---|
Mechanism of Xiaojianzhong decoction in alleviating aspirin-induced gastric mucosal injury revealed by transcriptomics and metabolomics.
Topics: Aspirin; Drugs, Chinese Herbal; Gastric Mucosa; Humans; Inflammation; Metabolomics; Molecular Dockin | 2024 |
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Topics: AMP-Activated Protein Kinases; Animals; Aspirin; Drugs, Chinese Herbal; Gastric Mucosa; Mice; Mice, | 2023 |
Foreword.
Topics: Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Patient Compliance; Platelet Agg | 2017 |
Reactive increase in gastric mucus secretion is an adaptive defense mechanism against low-dose aspirin-induced gastropathy.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Agents; Humans; M | 2013 |
Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment.
Topics: Aspirin; Cardiovascular Diseases; Female; Gastric Mucosa; Gastroscopy; Healthy Volunteers; Humans; H | 2013 |
The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection.
Topics: Adenoma; Aged; Anti-Ulcer Agents; Anticoagulants; Aspirin; Carcinoma; Case-Control Studies; Clopidog | 2013 |
Predictors of favourable outcome in non-variceal upper gastrointestinal bleeding: implications for early discharge?
Topics: Age Factors; Aged; Aged, 80 and over; Aspirin; Blood Transfusion; Endoscopy, Digestive System; Esoph | 2014 |
Comparative effects of the anti-platelet drugs, clopidogrel, ticlopidine, and cilostazol on aspirin-induced gastric bleeding and damage in rats.
Topics: Animals; Aspirin; Cilostazol; Clopidogrel; Hemoglobins; Hemorrhage; Male; Peroxidase; Platelet Aggre | 2014 |
Clinical outcomes of nonvariceal upper gastrointestinal bleeding in Kosova.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An | 2014 |
[Protective effect of compound bismuth and magnesium granules on aspirin-induced gastric mucosal injury in rats].
Topics: Animals; Antacids; Aspirin; Bismuth; Gastric Mucosa; Inflammation; Interleukin-1; Interleukin-2; Int | 2016 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont | 2016 |
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont | 2016 |
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont | 2016 |
Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.
Topics: Aged; Aged, 80 and over; Angiodysplasia; Aspirin; Blood Component Transfusion; California; Case-Cont | 2016 |
Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cycl | 2016 |
Acute phase protein response in dogs with experimentally induced gastric mucosal injury.
Topics: Acute-Phase Proteins; Animals; Aspirin; Dog Diseases; Dogs; Female; Gastric Mucosa; Male; Stomach Di | 2008 |
Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy.
Topics: Aged; Aspirin; Endoscopy, Gastrointestinal; Fibrinolytic Agents; Gastric Acid; Gastric Mucosa; Gastr | 2011 |
Association of gastric acid and mucus secretion level with low-dose aspirin-induced gastropathy.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Gastric Acid; Gastric Mucosa; Humans | 2012 |
Biphasic effects of H. pylori infection on low-dose aspirin-induced gastropathy depending on the gastric acid secretion level.
Topics: Aged; Aspirin; Drug Administration Schedule; Female; Fibrinolytic Agents; Gastric Acid; Helicobacter | 2012 |
Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Bleeding Time; Carotid Artery Thrombosis; Drug Thera | 2012 |
Correlation between erosive oesophageal and gastro-duodenal diseases. the influence of aspirin, simple analgesics, and Helicobacter pylori.
Topics: Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Duode | 2002 |
The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment - Prompt Endoscopy (CADET-PE) study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Barret | 2003 |
Aspirin and gastric haemorrhage.
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Stomach; Stomach Diseases | 1955 |
[Gastric hemorrhage following acetylsalicylic acid ingestion].
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Stomach; Stomach Diseases | 1957 |
Salicylates and gastric hemorrhage. I. Occult bleeding.
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Salicylates; Stomach; Stomach Diseases | 1957 |
Salicylates and gastric hemorrhage. II. Manifest bleeding.
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Salicylates; Stomach; Stomach Diseases | 1957 |
Occult blood in faeces after administration of aspirin.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Feces; Gastrointestinal Hemorrhage; Hemorrhage; Humans; O | 1958 |
Aspirin and gastric haemorrhage.
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Stomach; Stomach Diseases | 1959 |
[Severe hematemesis caused by acute gastric ulceration following massive absorption of aspirin].
Topics: Aspirin; Hematemesis; Humans; Stomach Diseases; Stomach Ulcer | 1959 |
[Gastric hemorrhage after aspirin].
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemorrhage; Stomach Diseases | 1961 |
[New considerations on the treatment of gastric disorders produced by salicylate].
Topics: Achlorhydria; Arthritis; Arthritis, Rheumatoid; Aspirin; Gastric Juice; Salicylates; Stomach Disease | 1962 |
GASTRIC MUCOSAL INJURY BY FATTY AND ACETYLSALICYLIC ACIDS.
Topics: Animals; Aspirin; Butyrates; Dogs; Fatty Acids; Gastric Mucosa; Hydrochloric Acid; Mannitol; Mucous | 1964 |
MECHANISM OF GASTRIC INJURY BY ASPIRIN.
Topics: Aspirin; Carbohydrate Metabolism; Chemical Phenomena; Chemistry; Dogs; Gastric Mucins; Gastric Mucos | 1964 |
Aspirin and gastric bleeding: further studies of calcium aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium; Gastrointestinal Hemorrhage; Humans; Pept | 1961 |
Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide.
Topics: Adaptation, Biological; Animals; Aspirin; Blotting, Western; Capsaicin; Gastric Acid; Gastric Mucosa | 2004 |
The rise and decline of nonsteroidal antiinflammatory drug-associated gastropathy in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Female; Humans; Ibuprofen; | 2004 |
Minidose aspirin and gastrointestinal bleeding--a retrospective, case-control study in hospitalized patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Dose-Response Relation | 2005 |
Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cloning, Molecular; Cyst | 2005 |
A novel water-soluble vitamin E derivative protects against aspirin-induced gastric mucosal injury in rats.
Topics: Animals; Aspirin; Chemokine CXCL1; Chemokines, CXC; Chromans; Gastric Mucosa; Glycosides; Intercellu | 2005 |
Education and imaging. Gastrointestinal: enhanced gastric mucosal blood flow in aspirin intoxication.
Topics: Adult; Aspirin; Cyclooxygenase Inhibitors; Female; Gastric Mucosa; Humans; Regional Blood Flow; Repe | 2007 |
Relationship between lesion production, absorption, and distribution of 14C-labeled acetylsalicylic acid.
Topics: Adrenal Glands; Animals; Aspirin; Autoradiography; Carbon Isotopes; Gastric Mucosa; Kidney; Male; Mu | 1967 |
Aspirin-induced damage in the dog Heidenhain pouch and cytoprotection with 16,16-dimethyl PGE2.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Disease Models, Animal; Dogs; Female; Gastric Muco | 1984 |
3-Methoxy-5,7,3',4'-tetrahydroxyflavan (ME): a new compound to prevent gastric irritation. A gastric potential difference analysis.
Topics: Aspirin; Catechin; Dose-Response Relationship, Drug; Flavonoids; Gastric Mucosa; Humans; Irritants; | 1983 |
Comparative gastric irritation by two buffered acetylsalicylic acid formulations and acetylsalicylic acid. A gastric potential difference analysis.
Topics: Adult; Aspirin; Buffers; Female; Gastric Mucosa; Humans; Irritants; Male; Membrane Potentials; Stoma | 1983 |
Role of locally generated prostaglandins in adaptive gastric cytoprotection.
Topics: Animals; Aspirin; Epoprostenol; Ethanol; Female; Gastric Mucosa; Irritants; Male; Prostaglandins; Pr | 1982 |
The pathogenesis of the aspirin-related gastric lesion.
Topics: Anti-Inflammatory Agents; Aspirin; Cyclooxygenase Inhibitors; Gastric Acid; Gastric Mucosa; Humans; | 1981 |
Effect of anti-inflammatory drug administration in patients with rheumatoid arthritis. An endoscopic assessment.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Therapy, Combination; Duodenal Diseas | 1981 |
Gastric distress evoked by anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; Humans; Stomach Diseases | 1980 |
[Gastric damage caused by acetylsalicylic acid].
Topics: Aspirin; Humans; Stomach Diseases | 1982 |
Gastroscopic evaluation of anti-inflammatory agents.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Administration Schedule; | 1980 |
Effects of 16, 16-dimethyl prostaglandin E2 methyl ester on aspirin-and indomethacin-induced gastrointestinal lesions in dogs.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Dogs; Gastric Mucosa; Indomethacin; Intestinal Dis | 1980 |
Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.
Topics: Animals; Aspirin; Capillaries; Endothelium; Female; Gastric Mucosa; Microscopy, Electron; Rats; Stom | 1980 |
A mechanism for prostaglandin cytoprotection.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Dogs; Female; Gastric Mucosa; Male; Pressure; Pros | 1980 |
Role of endogenous gastrin in gastroprotection.
Topics: Animals; Aspirin; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; | 1995 |
JB-9322, a new selective histamine H2-receptor antagonist with potent gastric mucosal protective properties.
Topics: Animals; Aspirin; Ethanol; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine H2 Antagonists; In V | 1995 |
Mucosal adaptation to aspirin induced gastric damage in humans. Studies on blood flow, gastric mucosal growth, and neutrophil activation.
Topics: Adaptation, Physiological; Adult; Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; | 1994 |
Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Ulcer Agents; Aspirin; Cells, Cultured; Chromium Radio | 1994 |
Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem.
Topics: Animals; Antacids; Aspirin; Biological Availability; Butadienes; Depression, Chemical; Diarrhea; Dog | 1994 |
Aspirin and bismuth subsalicylate.
Topics: Aspirin; Bismuth; Child; Humans; Organometallic Compounds; Salicylates; Stomach Diseases | 1993 |
Aspirin and the prevention of thrombosis.
Topics: Aspirin; Humans; Platelet Aggregation; Stomach Diseases; Thrombosis | 1993 |
Ulcer risk factors: interactions between Helicobacter pylori infection, nonsteroidal use, and age.
Topics: Adult; Age Factors; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Fema | 1993 |
Noninvasive detection of nonsteroidal anti-inflammatory drug-induced gastropathy in dogs.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dog Diseases; Dogs; | 1995 |
Repair of rat gastric mucosa: effect of 16,16-dimethyl prostaglandin E2.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; | 1997 |
Is Helicobacter pylori infection a risk or protective factor for mucosal lesions development in patients chronically treated with acetylsalicylic acid?
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Dru | 1997 |
Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer.
Topics: Aspirin; Female; Humans; Intestinal Diseases; Male; Middle Aged; Peptic Ulcer; Postoperative Complic | 1998 |
Prevention of ethanol-induced gastric lesions in rats by wu-bei-san.
Topics: Animals; Aspirin; Calcium Carbonate; Drugs, Chinese Herbal; Ethanol; Gastric Mucosa; Indomethacin; M | 1998 |
[Aspirin and surgery].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy; Gastroi | 1997 |
Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Cyclooxygenase 2; Dinoprosto | 1998 |
Effects of pectin-induced passive linkage of gastric H+ on the gastric acid secretion on the development of ethanol- and salicylate-induced gastric mucosal lesions in rats.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastric Mucosa; Hydrochlo | 1999 |
Does gastroscopy induce myocardial ischemia in patients with coronary heart disease?
Topics: Adult; Aged; Aspirin; Coronary Disease; Electrocardiography, Ambulatory; Esophageal Diseases; Exerci | 2000 |
Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa; | 2000 |
Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Carnosine; Gastric Muc | 2001 |
Role of the parietal cell in gastric damage induced by aspirin and related drugs: implications for safer therapy.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Gastric Juice; Gastric Mucosa; Humans; Hydrogen-Ion Conc | 1976 |
Effects of L-glutamine on acetylsalycylic acid induced gastric lesions and acid back diffusion in dogs.
Topics: Animals; Aspirin; Diffusion; Dogs; Gastric Mucosa; Glutamine; Hydrogen-Ion Concentration; In Vitro T | 1976 |
[Histochemical evidence of mucopolysaccharides of the gastric mucosa in drug-induced gastric disorders (author's transl)].
Topics: Adult; Aspirin; Female; Gastric Mucosa; Glycosaminoglycans; Humans; Male; Middle Aged; Phenylbutazon | 1977 |
Inhibitory effect of L-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat.
Topics: Animals; Aspirin; Depression, Chemical; Diffusion; Gastric Juice; Gastric Mucosa; Glutamine; Hydroge | 1975 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy.
Topics: Adult; Aged; Aspirin; Buffers; Female; Gastroscopy; Humans; Male; Middle Aged; Rheumatic Diseases; S | 1979 |
Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.
Topics: Aspirin; Delayed-Action Preparations; Humans; Stomach Diseases | 1978 |
Electron microscopic study of the repair of aspirin-induced gastric erosions.
Topics: Animals; Aspirin; Cell Differentiation; Cytoplasm; Enzyme Precursors; Female; Gastric Mucosa; Micros | 1976 |
Hour-glass stomach: an explanation.
Topics: Adult; Aged; Aspirin; Constriction, Pathologic; Female; Humans; Male; Middle Aged; Sex Factors; Stom | 1976 |
Influence of pregnancy on the development of various gastric lesions in rats.
Topics: Animals; Aspirin; Epinephrine; Female; Gastric Juice; Histamine; Lactation; Models, Biological; Preg | 1976 |
[Side and toxic effects of salicylates].
Topics: Aspirin; Chemical and Drug Induced Liver Injury; Female; Heart Diseases; Humans; Kidney Diseases; Ma | 1976 |
Role of taurocholic acid in production of gastric mucosal damage after ingestion of aspirin.
Topics: Aspirin; Bile; Drug Synergism; Gastric Mucosa; Humans; Membrane Potentials; Stomach Diseases; Tauroc | 1975 |
Enteric-coated aspirin overdose and gastric perforation.
Topics: Acetaminophen; Aged; Aspirin; Female; Humans; Stomach Diseases; Tablets, Enteric-Coated | 1975 |
Effect of stress and aspirin on extrahepatic portal hypertension in rats.
Topics: Animals; Aspirin; Blood Pressure; Collateral Circulation; Constriction; Gastric Juice; Gastric Mucos | 1975 |
Letter: Enteric-coated aspirin overdose and gastric perforation.
Topics: Acetaminophen; Aged; Aspirin; Humans; Phenylbutazone; Stomach Diseases | 1975 |
[Are gastroscopy and aimed gastrobiopsy expedient in the study of drug-induced stomach diseases?].
Topics: Aspirin; Biopsy; Gastric Mucosa; Gastroscopy; Humans; Stomach Diseases | 1975 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and | 1976 |
Possible low-dose-aspirin-induced gastropathy.
Topics: Aspirin; Female; Gastric Mucosa; Humans; Pregnancy; Pregnancy Complications; Stomach Diseases | 1992 |
Morphological study of gastric lesions developing in the rat under several damaging conditions: modifications induced by pretreatment with zinc acexamate.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Female; Gastric Muc | 1992 |
Ranitidine, aspirin, food, and the stomach.
Topics: Administration, Oral; Adult; Aspirin; Dose-Response Relationship, Drug; Female; Food; Gastric Mucosa | 1992 |
Role of polyamines in gastroprotection induced by epidermal growth factor.
Topics: Animals; Aspirin; Dinoprostone; Eflornithine; Epidermal Growth Factor; Ethanol; Gastric Acid; Gastri | 1991 |
Aspirin.
Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation Disorders; Cell Membr | 1991 |
Gastric microvascular endothelium: a major target for aspirin-induced injury and arachidonic acid protection. An ultrastructural analysis in the rat.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Capillaries; Endothelium, Vascular; Fluoresce | 1990 |
Frequency of gastroduodenal lesions in asymptomatic patients on chronic aspirin or nonsteroidal antiinflammatory drug therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Duodenal Diseases; Endoscopy; Female; | 1990 |
Rioprostil prevents aspirin-induced fecal blood loss in dogs. Correlation of Hemoquant (Hb) with endoscopic findings.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Dogs; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gast | 1989 |
[Pain of gastric origin caused by aspirin and smoking].
Topics: Adult; Aspirin; Humans; Male; Middle Aged; Pain; Smoking; Stomach Diseases | 1988 |
[Effects of troxipide on acute gastric lesions in rats].
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Hydrochloric Acid; Imme | 1987 |
Circadian variation of susceptibility to gastric mucosal injury by acidified aspirin or absolute ethanol in the rat.
Topics: Animals; Aspirin; Circadian Rhythm; Disease Susceptibility; Ethanol; Gastric Mucosa; Male; Rats; Sto | 1986 |
[Weakness of the gastric mucous barrier and hypersthenic dyspepsia].
Topics: Aspirin; Colonic Diseases; Dyspepsia; Gastric Mucosa; Gastroscopy; Humans; Membrane Potentials; Stom | 1985 |
[Effects of gefarnate on acute gastric lesions in rats].
Topics: Acute Disease; Animals; Aspirin; Cimetidine; Ethanol; Gefarnate; Male; Rats; Rats, Inbred Strains; S | 1985 |
Aspirin, alcohol, and gastric haemorrhage.
Topics: Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Stomach Diseases; Telangiectasis; | 1969 |
[Gastric and duodenal hemorrhage after drug administration].
Topics: Analgesics; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Chloramphenicol; Duodenal Diseases; G | 1973 |
Are pepsinogens activated in gastric mucosa after aspirin-induced injury?
Topics: Animals; Aspirin; Electrophoresis; Enzyme Activation; Gastric Mucosa; Hydrogen-Ion Concentration; In | 1974 |
Gastric mucosal injury by aspirin.
Topics: Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Stomach Diseases | 1966 |
Lesions associated with gastroduodenal haemorrhage, in relation to aspirin intake.
Topics: Adult; Aged; Aspirin; Duodenal Ulcer; Gastrointestinal Hemorrhage; Gastroscopy; Hematemesis; Humans; | 1968 |
Evaluation of gastric acid as a factor in drug-induced gastric hemorrhage in the rat.
Topics: Animals; Aspirin; Gastric Juice; Gastrointestinal Hemorrhage; Glycine; Hexoses; Histamine; Phenylbut | 1969 |
Arthritis, aspirin, and coma.
Topics: Arthritis, Juvenile; Aspirin; Brain Edema; Chemical and Drug Induced Liver Injury; Child, Preschool; | 1970 |
[Changes in the gastric mucosa by peroral antirheumatic drugs].
Topics: Anti-Inflammatory Agents; Antipyrine; Aspirin; Gastric Acidity Determination; Gastric Mucosa; Humans | 1969 |
Uptake of drugs by normal and diseased human gastric mucosa: in vitro experiments with labelled acetylsalicylic acid and thiopentone.
Topics: Aspirin; Autopsy; Biopsy; Carbon Isotopes; Esophagus; Gastric Mucosa; Humans; Hydrogen-Ion Concentra | 1970 |
Influence of gastric atrophy on the susceptibility of the gastric mucosa to injury by aspirin.
Topics: Achlorhydria; Animals; Aspirin; Atrophy; Gastric Acidity Determination; Gastric Juice; Gastric Mucos | 1970 |
Further studies on aspirin-induced gastric lesions in the guinea-pig.
Topics: Animals; Aspirin; Atropine; Female; Gastric Juice; Gastric Mucosa; Guinea Pigs; Hexamethonium Compou | 1965 |